4
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Abnormal tau proteins and neuronal degeneration in Alzheimer's disease

&
Pages 349-360 | Published online: 11 Jul 2009

References

  • Alonso A., Del C., Zaidi T., Grundke-Iqbal K. Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proceedings of the National Academy of Sciences, USA 1994; 91: 5562–5566
  • Arriagada P.V., Growden J.H., Hedley-White T., Hyman B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992; 42: 631–639
  • Berg L., McKeel D. W., Jr., Miller J.P., Baty J., Morris J.C. Neuropathological indexes of Alzheimer's disease ion demented and nondemented people aged 80 years and older. Archives of Neurology 1993; 50: 349–358
  • Biernat J., Gustke G., Mandelkow E.-M., Mandelkow E. Phosphorylation of Ser 272 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron 1993; 11: 153–163
  • Bondareff W., Wischik C.M., Novak M., Amos W.B., Klug A., Roth M. Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. American Journal of Pathology 1990; 137: 711–723
  • Bondareff W., Mountjoy Q-C., Wischik C.M., Hauser D.L., Labree L.D., Roth M. Evidence of subtypes of Alzheimer's disease and implications for etiology. Archives of General Psychiatry 1993; 50: 350–356
  • Bondareff W., Harrington C., Wischik C.M., Hauser D.L., Roth M. Immunohistochemical staging of neurofibrillary degeneration in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 1994; 53: 158–164
  • Bondareff W., Harrington C.R., Wischik C.M., Hauser D.L., Roth M. Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 1995; 54: 657–663
  • Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. ACTA Neuropathologica 1991; 82: 239–259
  • Bramblett G.T., Goedert M., Jakes R., Merrick S.E., Trojanowski J.Q., Lee V. M.-Y. Abnormal tau phosphorylation at ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 1993; 10: 1089–1099
  • Brion J.P., Hanger D.P., Bruce M.T., Couck A.-M., Flament-Durand J., Anderton B.H. Tau in Alzheimer neurofibrillary tangles N-and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site. Biochemical Journal 1991; 273: 127–133
  • Bush M.L., Miyashiro J., Ingram V.M. Activation of a neurofilament kinase, tau kinase, and a tau phosphatase by decreased ATP levels in nerve growth factor-differentiated PC-12 cells. Proceedings of the National Academy of Sciences, USA 1995; 92: 1861–1865
  • Correas I., Diaz-Nido J., Avila J. Microrubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain. Journal of Biological Chemistry 1992; 22: 15721–15728
  • Crowther R.A. Tau protein and paired helical filaments of Alzheimer's disease. Current Opinion in Structural Biology 1993; 3: 202–206
  • Crowther R.A., Olesen O.F., Jakes R., Goedert M. The microtubule binding repeats of tau protein assembly into filaments like those found in Alzheimer's disease. FEBS Letters 1992; 309: 199–202
  • Crowther R.A., Olesen O.F., Smith M.J., Jakes R., Goedert M. Assembly of Alzheimerlike filaments from full-length tau protein. FEBS Letters 1994; 337: 135–138
  • Drechsel D.N., Hyman A.A., Cobb M.W., Kirschner M.W. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Molecular Biology of the Cell 1992; 3: 1141–1154
  • Drubin D.G., Kirschner M.W. Tau protein function in living cells. Journal of Cell Biology 1986; 103: 2739–2746
  • Goedert M., Spillantini M.G., Jakes R., Rutherford D., Crowther R.A. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 1989; 3: 519–526
  • Goedert M., Spillantini M.G., Jakes R. Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau. Neuroscience Letters 1991; 126: 149–154
  • Goedert M., Spillantini M.G., Cairns N.J., Crowther R.A. Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 1992; 4: 159–168
  • Goedert M., Jakes R., Crowther R.A., Six J., Lubke U., Vandermeeren M., Cras P., Trojanowski J.Q., Lee V. M.-Y. The abnormal phosphorylation of tau protein at ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proceedings of the National Academy of Sciences, USA 1993; 90: 5066–5070
  • Goedert M., Jakes R., Crowther A., Vanmechelen E., Vandermeeren M., Crass P. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. Biochemical Journal 1994; 301: 871–877
  • Goedert M., Jakes R., Spillantini M.G., Crowther R.A., Cohen P., Vanmechelen E., Probst A., Götz J., Bürki K. Tau protein in Alzheimer's disease. Biochemical Society Transactions 1995; 23: 80–85
  • Greenberg S.G., Davies P.A. A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proceedings of the National Academy of Sciences, USA 1990; 87: 5827–5831
  • Hagestedt T., Lichtenberg M., Wille H., Mandelkow E.-M., Mandelkow E. Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation. Journal of Cell Biology 1989; 109: 1643–1651
  • Harrington C.R., Mukaetova-Ladinska E.B., Hills R., Edwards P.C., Montejo de Garcini E., Novak M., Wischik C.M. Measurement of distinct immunochemical presentations of tau protein in Alzheimer's disease. Proceedings of the National Academy of Sciences, USA 1991; 88: 5842–5846
  • Horwttz S.B., Cohen D., Rao S., Ringel I., Shen H.-J., Yang C.-P. Taxol: mechanisms of action and resistance. Journal of the National Cancer Institute Monographs 1993; 15: 55–61
  • Hyman B.T., Van Hoesen G.W., Wolozin B.L., Davies P., Kromer L.J., Damasio A.R. Alz-50 antibody recognizes Alzheimer-related neuronal changes. Annals of Neurology 1988; 23: 371–379
  • Iqbal K., Zaidi Y., Wen G.Y., Grundke-Iqbal I., Merz P.A., Shaikh S.S., Wisniewski H.M. Defective brain microtubule assembly in Alzheimer's disease. Lancet August 23, 1986; 421–426
  • Kidd M. Paired helical filaments in electron microscopy in Alzheimer's disease. Nature 1963; 197: 192–193
  • Kondo J., Honda T., Mori H., Hamada Y., Miura R., Ogawara M., Ihara Y. The carboxyl third of tau is tightly bound to paired helical filaments. Neuron 1988; 1: 827–834
  • Ksiezak-Reding H., Davies P., Yen S.-H. Alz-50, a monoclonal antibody to Alzheimer's disease antigen cross-reacts with tau proteins from bovine and normal human brain. Journal of Biological Chemistry 1988; 262: 7943–7947
  • Ksiezak-Reding H., Wall J.S. Mass and physical dimensions of two distinct populations of paired helical filaments. Neurobiology of Aging 1994; 15: 11–19
  • Lai R.Y.K., Gertz H.-J., Wischik D.J., Xuerub J.H., Mukaetova-Ladinska E.B., Harrington C.R., Edwards P.C., Paykel E.S., Brayne C., Hup-Pert F.A., Roth M., Wischik C.M. Examination of phosphorylated tau protein as a PHF-precursor in early stage Alzheimer's disease. Neurobiology of Aging 1995; 16: 433–445
  • Lee V. M.-Y., Baun B.J., Otvos L., Jr, Trojanowski J.Q. A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 1991; 251: 675–678
  • Lee V. M.-Y, Daughenbaugh R., Trojanowski J.Q. Microtubule stabilizing drugs for the treatment of Alzheimer's disease. Neurobiology of Aging 1994; 15(2)S87–S89
  • Livingston G. The scale of the problem. Dementia, A. Burns, R. Lew. Chapman and Hall, London 1994; 21–35
  • Luckenbill-Edds L., Van Horn C., Greene L.A. Fine structure of initial outgrowth of processes induced in a pheochromocytoma cell line (PC 12) by nerve growth factor. Journal of Neurocytology 1979; 8: 493–511
  • Matsuo E.S., Shin R.-W., Billingsley M.L., Van Devoorde A., O'Connor M., Trojanowski J.Q., Lee V. M.-Y. Biopsyderived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 1994; 13: 989–1002
  • Matsuyama S.S., Jarvik L.F. Hypothesis: microtubules—A key to Alzheimer disease. Proceedings of the National Academy of Sciences, USA 1989; 86: 8152–8156
  • McKee A.C., Kosik K.S., Kowall N.W. Neuritic pathology and dementia in Alzheimer's disease. Annals of Neurology 1991; 30: 156–165
  • Mukaetova-Ladinska E.B., Harrington C.R., Roth M., Wischik C.M. Biochemical and anatomical redistribution of tau protein in Alzheimer's disease. American Journal of Pathology 1993; 143: 565–578
  • Novak M., Jakes R., Edwards P.C., Milstein C., Wischik C.M. Difference between the tau protein of Alzheimer's disease paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51. Proceedings of the National Academy of Sciences, USA 1991; 88: 5837–5841
  • Novak M., Kabat J., Wischik C.M. Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament. EMBO, Journal 1993; 12: 367–370
  • Nuktna N., Kosik K.S., Selkoe D.J. The monoclonal antibody, Alz-50, recognizes tau proteins in Alzheimer's disease. Neuroscience Letters 1988; 87: 240–246
  • Roush W.L. Protein studies try to puzzle out Alzheimer's tangles. Science 1995; 267: 793–794, editorial
  • Rubenstein R., Kascsak R.J., Merz P.A., Wisniewski H.M., Carp R.I., Iqbal K. Paired helical filaments associated with Alzheimer disease are readily soluble structures. Brain Research 1986; 372: 80–88
  • Schmidt M.L., Gur R.E., Gur R.C., Trojanowski J.Q. Intraneuronal and extracellular neurofibrillary tangles exhibit mutually exclusive cytoskeletal antigens. Annals of Neurology 1988; 23: 184–189
  • Terry R.D., Gonatas N.K., Weiss M. Ultrastructural studies in Alzheimer's presenile dementia. American Journal of Pathology 1964; 44: 669–697
  • Trojanowski J.Q., Lee V. M.-Y. Paired helical filament T in Alzheimer's disease. The kinase connection. American Journal of Pathology 1994; 144: 449–453
  • Wallace W., Johnson G., Sugar J., Merril C.R., Refolo L.M. Reversible phosphorylation of tau to form A68 in heat-shocked neuronal PC 12 cells. Molecular Brain Research 1993; 19: 149–155
  • Wilson L. Action of drugs on microtubules. Life Science 1975; 17: 303–310
  • Wilcock G.K., Esiri M.M. Plaques, tangles and dementia: a quantitative study. Journal of Neurological Science 1982; 56: 343–356
  • Wischik C.M., Novak M., Thogersen H.C., Edwards P.C., Runswick M.J., Jakes R., Walker J.E., Milstein C., Roth M., Klug A. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proceedings of the National Academy of Sciences, USA 1988; 85: 4506–4510
  • Wischik C.M., Lai R., Edwards P.C., Gertz H.J., Xuereb J.H., Paykel E.S., Brayne C., Huppert F.A., Mukaetova-Ladinska E.B., Harrington C.R., Roth M. Quantitative analysis of tau protein in paired helical filament (PHF) preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease. Neurobiology of Aging 1995; 16
  • Wischik C.M., Edwards P.C., Lai R.Y.K., Harrington C.R., Roth M. Self-propagating aggregation of tau protein: a therapeutic target in Alzheimer's disease. 1995, In press
  • Wolozin B.L., Pruchniki A., Dickson D.W., Davies P. A neuronal antigen in the brains of Alzheimer patients. Science 1986; 232: 648–650

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.