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Pruritus

A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain

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Pages 367-372 | Received 15 Aug 2014, Accepted 10 Oct 2014, Published online: 11 Feb 2015

References

  • Duque MI, Vogel CA, Fleischer AB, Jr Yosipovitch G. Over-the-counter topical antipruritic agents are commonly recommended by office-based physicians: an analysis of US practice patterns. J Dermatol Treat. 2004;15:185–8
  • Hercogova J. Topical anti-itch therapy. Dermatol Ther. 2005;18:341–3
  • Wang GK, Quan C, Wang S. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Archiv: Eur J Physiol. 1998;435:293–302
  • Graser GN. The efficacy of topical anesthetics in reducing intraoral discomfort. Oral Surg Oral Med Oral Pathol. 1984;58:42–6
  • Hersh EV, Cooper SA, Segal H, Greene J. Analgesic onset time as a measure of topical anesthetic efficacy in spontaneous toothache pain: a pilot study. J Clin Dent. 1993;4:52–4
  • Hersh EV, DeRossi SS, Ciarrocca KN, et al. Efficacy and tolerability of an intraoral benzocaine patch in the relief of spontaneous toothache pain. J Clin Dent. 2003;14:1–6
  • Nayak R, Sudha P. Evaluation of three topical anaesthetic agents against pain: a clinical study. Indian J Dent Res. 2006;17:155–60
  • Nusstein JM, Beck M. Effectiveness of 20% benzocaine as a topical anesthetic for intraoral injections. Anesth Prog. 2003;50:159–63
  • Roghani S, Duperon DF, Barcohana N. Evaluating the efficacy of commonly used topical anesthetics. Pediatr Dent. 1999;21:197–200
  • Rosa AL, Sverzut CE, Xavier SP, Lavrador MA. Clinical effectiveness of lidocaine and benzocaine for topical anesthesia. Anesth Prog. 1999;46:97–9
  • Sveen OB, Yaekel M, Adair SM. Efficacy of using benzocaine for temporary relief of toothache. Oral Surg Oral Med Oral Pathol. 1982;53:574–6
  • Eslamian L, Borzabadi-Farahani A, Edini HZ, et al. The analgesic effect of benzocaine mucoadhesive patches on orthodontic pain caused by elastomeric separators, a preliminary study. Acta Odontol Scand. 2013;71:1168–73
  • Busch R, Graubaum HJ, Grunwald J, Schmidt M. Double-blind comparison of two types of benzocaine lozenges for the treatment of acute pharyngitis. Arzneimittel-Forschung. 2010;60:245–8
  • Gill CJ, Orr II DL. A double-blind crossover comparison of topical anesthetics. J Am Dental Assoc. 1979;98:213–14
  • Paschos E, Huth KC, Benz C, et al. Efficacy of intraoral topical anesthetics in children. J Dent. 2006;34:398–404
  • Finkel M, Levine AJ, Wohl M. Twenty per cent dissolved benzocaine ointment in the treatment of burns, ulcers and local necroses. Ind Med Surg. 1948;17:475
  • Higuchi T, Lach JL. Investigation of some complexes formed in solution by caffeine. IV. Interactions between caffeine and sulfathiazole, sulfadiazine, p-aminobenzoic acid, benzocaine, phenobarbital, and barbital. J Am Pharm Assoc Am Pharm Assoc. 1954;43:349–54
  • Bertram RO, Weinstock BS. A clinical evaluation of chlorophyll, benzocaine and urea ointment in treatment of minor infections of the foot. J Am Podiatr Assoc. 1959;49:336–8
  • Taleb M, Ashraf Z, Valavoor S, Tinkel J. Evaluation and management of acquired methemoglobinemia associated with topical benzocaine use. Am J Cardiovasc Drugs. 2013;13:325–30
  • Moore TJ, Walsh CS, Cohen MR. Reported adverse event cases of methemoglobinemia associated with benzocaine products. Arch Intern Med. 2004;164:1192–6
  • Bouziri A, Khaldi A, Menif K, Ben Jaballah N. Unusual cause of severe toxic methemoglobinemia in an infant: a case report. Int J Emerg Med. 2010;3:57–9
  • Stander S, Weisshaar E, Steinhof M, et al. [Pruritus–pathophysiology, clinical features and therapy – an overview]. J German Soc Dermatol. 2003;1:105–18
  • Melton FM, Shelley WB. The effect of topical antipruritic therapy on experimentally induced pruritus in man. J Invest Dermatol. 1950;15:325–32
  • Shelley WB, Melton FM. Relative effect of local anesthetics on experimental histamine pruritus in man. J Invest Dermatol. 1950;15:299–300
  • Simone DA, Ngeow JY, Whitehouse J, et al. The magnitude and duration of itch produced by intracutaneous injections of histamine. Somatosens Res. 1987;5:81–92
  • Papoiu AD, Tey HL, Coghill RC, et al. Cowhage-induced itch as an experimental model for pruritus: a comparative study with histamine-induced itch. PLoS One. 2011;6:e17786
  • Theunis J, Black D, Degouy A, et al. Comparison of perceived itch induced by skin prick-tests with histamine and codeine. Acta Dermato-Venereol. 2008;88:455–7
  • Andresen T, Staahl C, Oksche A, et al. Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain. Br J Pharmacol. 2011;164:934–45
  • Rother M, Rother I. Placebo controlled, crossover validation study of oral ibuprofen and topical hydrocortisone- 21-acetate for a model of ultraviolet B radiation (UVR)-induced pain and inflammation. J Pain Res. 2011;4:357–63
  • Czepa D, Böttger MK, Stephan H, et al. Wirkung einer Kälteapplikation auf die Schmerzempfindlichkeit bei Patienten mit Hämophilie – Ergebnisse einer randomisiert kontrollierten Studie. Conference Poster at the “42. Deutscher Sportärztekongress der DGSP” Frankfurt/Main, Germany, 2011
  • Buchanan HM, Midgley JA. Evaluation of pain threshold using a simple pressure algometer. Clin Rheumatol. 1987;6:510–17
  • Zhai H, Simion FA, Abrutyn E, et al. Screening topical antipruritics: a histamine-induced itch human model. Skin Pharmacol Appl Skin Physiol. 2002;15:213–17
  • McCormack HM, Horne DJ, Sheather S. Clinical applications of visual analogue scales: a critical review. Psychol Med. 1988;18:1007–19
  • Darsow U, Mautner VF, Bromm B, et al. [The Eppendorf Pruritus Questionnaire]. Der Hautarzt; Zeitschr Dermatol Venerol Verwandte Gebiete. 1997;48:730–3
  • Kosteletzky F, Namer B, Forster C, Handwerker HO. Impact of scratching on itch and sympathetic reflexes induced by cowhage (Mucuna pruriens) and histamine. Acta Dermato-Venereol. 2009;89:271–7
  • Dr. Ritsert Pharma GmbH & Co KG. Statistical evaluation of the Post Authorisation Safety Study conducted by Dr. Ritsert Pharma. Eberbach, Germany: Dr. Ritsert Pharma GmbH & Co KG, 2010
  • Dr. Ritsert Pharma GmbH & Co KG. Summary of product characteristics “Anaestherit Salbe 10%”. Eberbach, Germany: Dr. Ritsert Pharma GmbH & Co KG, 2014
  • Darsow U, Ring J, Scharein E, Bromm B. Correlations between histamine-induced wheal, flare and itch. Arch Dermatol Res. 1996;288:436–41
  • Elman S, Hynan LS, Gabriel V, Mayo MJ. The 5-D itch scale: a new measure of pruritus. Br J Dermatol. 2010;162:587–93
  • Pfab F, Huss-Marp J, Gatti A, et al. Influence of acupuncture on type I hypersensitivity itch and the wheal and flare response in adults with atopic eczema – a blinded, randomized, placebo-controlled, crossover trial. Allergy. 2010;65:903–10
  • Spiller HA, Revolinski DH, Winter ML, et al. Multi-center retrospective evaluation of oral benzocaine exposure in children. Vet Hum Toxicol. 2000;42:228–31
  • PAZ_Arzeinmittel-Entwicklungs_GmbH. Systematische verfügbarkeit von benzocain nach topischer applikation. Frankfurt/M, Germany: PAZ Arzneimittel-Entwicklungsgesellschaft mbH, 1992
  • Tantisattamo E, Suwantarat N, Vierra JR, Evans SJ. Atypical presentations of methemoglobinemia from benzocaine spray. Hawaii Med J. 2011;70:125–6
  • Birchem SK. Benzocaine-induced methemoglobinemia during transesophageal echocardiography. J Am Osteopath Assoc. 2005;105:381–4
  • Kane GC, Hoehn SM, Behrenbeck TR, Mulvagh SL. Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors. Arch Intern Med. 2007;167:1977–82
  • Hersh EV, Ciancio SG, Kuperstein AS, et al. An evaluation of 10 percent and 20 percent benzocaine gels in patients with acute toothaches: efficacy, tolerability and compliance with label dose administration directions. J Am Dent Assoc. 2013;144:517–26
  • Binshtok AM, Bean BP, Woolf CJ. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature. 2007;449:607–10
  • Roberson DP, Gudes S, Sprague JM, et al. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci. 2013;16:910–18

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