24
Views
5
CrossRef citations to date
0
Altmetric
Original Article

The human skin blanching assay for comparing topical corticosteroid availability

, , &
Pages 69-72 | Published online: 12 Jul 2009

References

  • Coleman G L, Magnus A D, Haigh J M, et al. Comparative blanching activities of locally manufactured proprietary fluocinolone acetonide topical preparations. S Afr Med J 1979; 56: 447–9
  • Meyer E. A critical evaluation of the human skin blanching assay and comparative bioavailability studies on topical corticosteroid preparations. PhD Thesis, School of Pharmaceutical Sciences, Rhodes University, GrahamstownSouth Africa 1989
  • Meyer E, Haigh J M, Kanfer I. Comparative bioavailability of some locally manufactured betamethasone valerate-containing preparations. S Afr Pharm J 1983; 50: 445–8
  • Coldman M F, Lockerbie L, Laws E A. The evaluation of several topical corticosteroid preparations in the blanching test. Br J Dermatol 1971; 85: 381–7
  • Asche H, Botta L, Rettig H, et al. Influence of formulation factors on the availability of drugs from topical preparations. Pharm Acta Helv 1985; 60: 232–7
  • Coleman G L, Kanfer I, Haigh J M. Comparative blanching activities of proprietary diflucortolone valerate topical preparations. Dermatologica 1978; 156: 224–30
  • Kirsch J, Gibson J R, Darley C R, et al. A comparison of the potencies of several diluted and undiluted corticosteroid preparations using the vasoconstrictor assay. Dermatologica 1983; 167: 138–41
  • Meyer E, Kanfer I, Haigh J M. Comparative blanching activities of some topical corticosteroidcontaining lotions. S. Afr Pharm J 1981; 48: 551–2
  • McKenzie A W, Stoughton R B. Method for comparing the percutaneous absorption of steroids. Arch Dermatol 1962; 86: 608–10
  • Falconi G, Rossi G L. Paper-patch test for evaluating vasoconstrictive activity of corticosteroids. Arch Dermatol 1972; 105: 856–8
  • Place V A, Velazques J G, Burdick K H. Precise evaluation of topically applied corticosteroid potency. Modification of the Stoughton- McKenzie assay. Arch Dermatol 1970; 101: 531–7
  • Barry B W, Woodford R. Comparative bio-availability and activity of proprietary topical corticosteroid preparations; vasoconstrictor assays on thirty-one ointments. Br J Dermatol 1975; 93: 563–71
  • Barry B W. Bioavailability of topical steroids. Dermatologica 1976; 152: 47–65
  • Barry B W, Woodford R. Comparative bio-availability of proprietary topical corticosteroid preparations; vascon-strictor assays on thirty creams and gels. Br J Dermatol 1974; 91: 323–8
  • Stoughton R B. Are generic formulations equivalent to trade name topical glucocorticoids. Arch Dermatol 1987; 123: 1312–14
  • Haigh J M, Kanfer I. Assessment of topical corticosteroid preparations: the human skin blanching assay. Int J Pharm 1984; 19: 245–62
  • Smith E W, Meyer E, Haigh J M, . The human skin blanching assay as an indicator of topical corticosteroid bioavailability and potency: an update. Percutaneous Absorption, R L Bronaugh, H I Maibach, et al. Marcel Dekker, New York 1989; vol 2: 443
  • Barry B W, Woodford R. Activity and bioavailability of topical steroids. In vivo/in vitro correlations for the vasoconstrictor test. J Clin Pharmacol 1978; 3: 43–65
  • Raymond G P, Collins J P, Mailhot R. Triple corticosteroid integrated system in the treatment of psoriasis: a new approach to topical corticosteroid therapy. Curr Ther Res 1985; 37: 770–8
  • Stoughton R B. Bioassay system for formulations of topically applied glucocorticosteroids. Arch Dermatol 1972; 106: 825–7
  • Burdick K H. Corticosteroid bioavailability assays: correlation with a clinical study. Acta Derm Venereol (Stockh) 1972; 52: 19–23
  • Smith E B, Gregory J F, Bartruff J K. Desonide, a potent nonfluorinated topical steroid, vasoconstriction assay and clinical trial. South Med J 1973; 66: 325–9
  • Whitefield M, McKenzie A W. A new formulation of 0.1% hydrocortisone cream with vasoconstrictor activity and clinical effectiveness. Br J Dermatol 1975; 92: 585–8
  • Stoughton R B. Penetration of drugs through the skin. Dermatologica 1976; 152: 27–36
  • Bluefarb S M, Howard F M, Leibsohn E, et al. Diflorasone diacetate: vasoconstrictor activity and clinical efficacy of a new topical corticosteroid. J Int Med Res 1976; 4: 454–61
  • Haleblian J K, Poulsen B J, Burdick K H. Development of fluocinonide gel: correlation of in vitro assays, in vivo bioassays and clinical trials. Curr Ther Res 1977; 22: 713–21
  • Cornell R, Stoughton R B. Correlation of the vasocostriction assay and clinical activity in psoriasis. Arch Dermatol 1985; 121: 63–7
  • Gibson J R. Predicting the topical potency of topical corticosteroids. CIin Exp Dermatol 1985; 10: 403–4
  • Engel D JC, Man A F, Rekker R F, et al. Topically active corticosteroids. A quantitative evaluation of McKenzie's skin-blanching test. Arch Dermatol 1974; 109: 863–5
  • Burdick K H. Various vagaries of vasoconstriction. Arch Dermatol 1974; 110: 238–42
  • Haigh J M, Kanfer I, Meyer E, et al. Relative potencies of topical corticosteroid formulations. Br J Dermatol 1985; 113: 502–3
  • Haigh J M, Kanfer I, Meyer E, et al. The human skin blanching assay — use and abuse. Br J Dermatol 1986; 114: 636–8
  • Metzler C M. Bioavailability — a problem in equivalence. Biometrics 1974; 30: 309–17
  • Meyer E, Magnus A D, Haigh J M, et al. Comparison of the blanching activities of Dermovate, Betnovate and Eumovate creams and ointments. Int J Pharm 1988; 41: 63–6
  • Gruvstad E, Bengtsson B. A comparison of a new steroid, budesonide, with other topical corticosteroids in the vasoconstrictor assay. Drugs Exp Clin Res 1980; 6: 385–90
  • Conner D P, Zamani K, Nix D, et al. Use of reflectance spectrometry in the corticosteroid skin blanching assay. Clin Pharmacol Ther 1990; 47: 170

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.