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Acute Radiation-Induced Alterations in Lymphocytes

Proteomic and genomic modulations induced by γ-irradiation of human blood lymphocytes

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Pages 888-904 | Received 26 Jan 2009, Accepted 09 Apr 2010, Published online: 23 Jul 2010

References

  • Amundson SA, Do KT, Shahab S, Bittner M, Meltzer P, Trent J, Fornace AJ. 2000. Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to IR. Radiation Research 154:342–346.
  • Amundson SA, Grace MB, Mcleland CB, Epperly MW, Yeager A, Zhan Q, Greenberger JS, Fornace AJ. 2004. Human in vivo radiation-induced biomarkers: Gene expression changes in radiotherapy patients. Cancer Research 64:6368–6371.
  • Bae I, Fan S, Bhatia K, Kohn KW, Fornace AJ, O'Connor PM. 1995. Relationship between G1 arrest and stability of the p53 and P21Cip1/Waf1 proteins following γ-irradiation of human lymphoma cells. Cancer Research 55:2387–2393.
  • Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. 1998. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proceedings of the National Academy of Sciences of the USA 29;95(20):11715–11720.
  • Chen C, Boylan MT, Evans CA, Whetton AD, Wright EG. 2005. Application of two-dimensional difference gel electrophoresis to studying bone marrow macrophages and their in vivo responses to ionizing radiation. Journal of Proteome Research 4:1371–1380.
  • Debey S, Schoenbeck U, Hellmich M, Gathof BS, Pillai R, Zander T, Schultze JL. 2004. Comparison of different isolation techniques prior gene expression profiling of blood derived cells: Impact on physiological responses, on overall expression and the role of different cell types. The Pharmacogenomics Journal 4:193–207.
  • Dressman HK, Muramoto GG, Chao NJ, Meadows S, Marshall D, Ginsburg GS, Nevins JR, Chute JP. 2007. Gene expression signatures that predict radiation exposure in mice and humans. PLOS Medicine 4:1–12.
  • Fotedar R, Bendjennat M, Fotedar A. 2004. Role of p21WAF1 in the cellular response to UV. Cell Cycle 3(2):134–137.
  • Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M, Bork P, von Mering C. 2009. STRING 8-a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res. 37(Database issue):D412–D416. Epub 2008 Oct 21.
  • Kang CM, Park KP, Song JE, Jeoung DI, Cho CK, Kim TH, Sangwoo B, Lee SJ, Lee YS. 2003. Possible biomarkers for IR exposure in human peripheral blood lymphocytes. Radiation Research 159:312–319.
  • King ICL, Sartorelli AC. 1986. The relationship between epidermal growth factor receptors and the terminal differentiation of A431 carcinoma cells. Biochemical and Biophysical Research Communications 140(3):837–843.
  • Lu X, de la Pena L, Barker C, Camphausen K, Tofilon PJ. 2006. Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes. Cancer Research 66:1052–1061.
  • Marchetti F, Coleman MA, Jones IM, Wyrobek AJ. 2006. Candidate protein biodosimeters of human exposure to IR. International Journal of Radiation Biology 82:605–639.
  • Nyström T. 2005. Role of oxidative carbonylation in protein quality control and senescence. The European Molecular Biology Organization Journal 24:1311–1317.
  • Ossetrova NI, Farese AM, MacVittie TJ, Manglapus GL, Blakely WF. 2007. The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6-Gy whole-body radiation model. Radiation Measurements 42(6–7):1158–1163.
  • Rechsteiner M, Rogers SW. 1996. PEST sequences and regulation by proteolysis. Trends Biochem Sci. 21(7):267–271.
  • Singh GP, Ganapathi M, Sandhu KS, Dash D. 2006. Intrinsic unstructuredness and abundance of PEST motifs in eukaryotic proteomes. Proteins 62(2):309–315.
  • Smith ML, Ford JM, Hollander MC, Bortnick RA, Amundson SA, Seo YR, Deng CX, Hanawalt PC, Fornace AJ Jr. 2000. p53-mediated DNA repair responses to UV radiation: Studies of mouse cells lacking p53, p21, and/or gadd45 genes. Molecular Cell Biology 20(10):3705–3714.
  • Stadtman ER, Levine RL. 2003. Free radical-mediated oxidation of free amino acids and amino acid residues in proteins. Amino Acids 25(3–4):207–218.
  • Szkanderova S, Port M, Stulik J, Hernychova L, Kasalova I, Van Beuningen D, Abend M. 2003. Comparison of the abundance of 10 radiation-induced proteins with their differential gene expression in L929 cells. International Journal of Radiation Biology 79(8):623–633.
  • Szkanderova S, Vavrova J, Hernychova L, Neubauerova V, Lenco J, Stulik J. 2005. Proteome alterations in gamma-irradiated human T-lymphocyte leukemia cells. Radiation Research 163:307–315.
  • Turtoi A, Srivastava A, Sharan RN, Oskamp D, Hille R, Schneeweiss FHA. 2007. Early response of lymphocyte proteins after γ-radiation. Journal of Radioanalytical and Nuclear Chemistry 274:435–439.
  • Turtoi A, Brown I, Oskamp D, Schneeweiss FHA. 2008. Early gene expression in human lymphocytes after γ-radiation – a genetic pattern with potential for biodosimetry. International Journal of Radiation Biology 84(5):375–387.
  • Van't Veer LJ, Lutz PM, Isselbacher KJ, Bernards R. 1992. Structure and expression of major histocompatibility complex-binding protein 2, a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes. Proceedings of the National Academy of Sciences of the USA 89:8971–8975.
  • Whiteley W, Jackson C, Lewis S, Lowe G, Rumley A, Sandercock P, Wardlaw J, Dennis M, Sudlow C. 2009. Inflammatory markers and poor outcome after stroke: A prospective cohort study and systematic review of interleukin-6. PLoS Medicine 6(9).
  • Zhang B, Su YP, Ai GP, Liu XH, Wang FC, Cheng TM. 2003. Differentially expressed proteins of gamma-ray irradiated mouse intestinal epithelial cells by two-dimensional electrophoresis and MALDI-TOF mass spectrometry. World Journal of Gastroenterology 9:2726–2731.
  • Zhang B, Yongping S, Fengchao W, Guoping A, Yongjiang W. 2005. Identification of differentially expressed proteins of gamma-ray irradiated rat intestinal epithelial IEC-6 cells by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Proteomics 5:426–432.

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