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CARBAMAZEPINE IS A RADIATION PROTECTOR/MITIGATOR

The autophagy-inducing drug carbamazepine is a radiation protector and mitigator

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Pages 1052-1060 | Received 09 Sep 2010, Accepted 10 May 2011, Published online: 05 Jul 2011

References

  • Alva AS, Gultekin SH, Baehrecke EH. 2004. Autophagy in human tumors: cell survival or death? Cell Death and Differentiation 11:1046–1048.
  • Boya P, Gonzalez-Polo R, Casares N, Perfettini J, Dessen P, Larochette N, Metivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G. 2005. Inhibition of macroautophagy triggers apoptosis. Molecular and Cellular Biology 15:1025–1040.
  • Brown AP, Chung EJ, Urick ME, Shield WP 3rd, Sowers AL, Thetford A, Shankavaram UT, Mitchell JB, Citrin DE. 2010. Evaluation of the fullerene compound DF-1 as a radioprotector. Radiation Oncology 5:34.
  • Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B. 2010. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 6:322–329.
  • Elmore SP, Qian T, Grissom SF, Lemasters JJ. 2001. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. Federation of American Societies for Experimental Biology 15: 2286–2287.
  • Epperly MW, Gretton JE, Bernarding M, Nie S, Rasul B, Greenberger JS. 2003. Mitochondrial localization of copper/zinc superoxide dismutase (Cu/ZnSOD) confers radioprotective functions in vitro and in vivo. Radiation Research 160:568–578.
  • Epperly MW, Sikora C, Defilippi S, Gretton J, Zhan Q, Kufe DW, Greenberger JS. 2002. MnSOD inhibits irradiation-induced apoptosis by stabilization of the mitochondrial membrane against the effects of SAP kinases p38 and Jnk1 translocation. Radiation Research 157:568–577.
  • Fu J, Shao CJ, Chen FR, Ng HK, Chen ZP. 2010. Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines. Neuro-Oncology 12:328–340.
  • Greenberger JS, Eckner RJ, Sakakeeny MA, Reid D, Nabel G, Hapel A, Ihle JN, Humphries KC. 1983. Effects of murine leukemia virus on generation of Interleukin-3 dependent hematopoietic progenitor cell lines from continuous marrow cultures. Federation Proceedings 42:106–115.
  • Hall EJ, Giaccia AJ. 2005. Radiobiology for the radiologist, 6th. Baltimore, MD: Lippincott, Williams and Wilkins.
  • Høyer-Hansen M, Jäättelä M. 2008. Autophagy: an emerging target for cancer therapy. Autophagy 4:574–580.
  • Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C, Maurice N, Mukherjee, A, Goldbach C, Watkins S, Michalopoulos G, Perlmutter DH. 2010. An autophagy-enhancing drug promotes degradation of mutant α1-Antitrypsin Z and reduces hepatic fibrosis. Science 329: 229–235.
  • Hippert MM, O'Toole PS, Thorburn A. 2006. Autophagy in cancer: good, bad, or both? Cancer Research 66:9349–9351.
  • Jiang J, McDonald P, Dixon TM, Franicola D, Zhang X, Nie S, Epperly LD, Kagan VE, Lazo JS, Epperly MW, Greenberger JS. 2009. Druggable genome siRNA library screening identifies Glybencamide as a novel radioprotector. Radiation Research 172:414–422.
  • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. The European Molecular Biology Organization Journal 19:5720–5728.
  • Kondo Y, Kanzawa T, Sawaya R, Kondo S. 2005. The role of autophagy in cancer development and response to therapy. Nature Reviews Cancer 5:726–734.
  • MacDonald RL, Kelly KM. 1995. Antiepileptic drug mechanisms of action. Epilepsia 36(Suppl. 2):S2–12.
  • Miller LP. 2010. Quantifying western blots without expensive commercial quantification software. http://lukemiller.org/index.php/2010/11/analyzing-gels-and-western-blots-with-image-/
  • Mizushima N, Yoshimori T, Levine B. 2010. Methods in mammalian autophagy research. Cell 140:313–326.
  • Oyesanmi O, Kunkel EJS, Monti DA, Field HL. 1999. Hematologic side effects of psychotropics. Psychosomatics 40:414–421.
  • Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D, Yahalom J. 2001. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Research 61:439–444.
  • Ralph P, Moore MAS, Nilsson K. 1976. Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines. Journal Experimental Medicine 143:1528–1533.
  • Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein KA, Rothstein R, Botrugno OA, Parazzoli D, Oldani A, Minucci S, Foiani M. 2011. HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature 471:74–80.
  • Sarkar S, Flato RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC. 2005. Lithium induces autophagy by inhibiting inositol monophosphatase. Journal of Cell Biology 170:1101–1111.
  • Shepherd JL and Associates. 2005. Isodose curve specifications for Shepherd Mark 1 Cesium Irradiator. 1010 Arroyo Street, San Fernando, CA 91340-1822, USA.
  • Shintani T, Klionsky DJ. 2004. Autophagy in health and disease: a double-edge sword. Science 306:990–995.
  • Thames HD, Jr., Rasmussen SL. 1978. A test for dose-modifying factors. Radiation Research 76:308–324.

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