141
Views
8
CrossRef citations to date
0
Altmetric
HYPOGRAVITY AND RADIATION EFFECTS IN LYMPHOCYTES

The combined effects of reduced weightbearing and ionizing radiation on splenic lymphocyte population and function

, , &
Pages 1033-1038 | Received 17 Dec 2010, Accepted 13 May 2011, Published online: 19 Jul 2011

References

  • Allebban Z, Ichiki AT, Gibson LA, Jones JB, Congdon CC, Lange RD. 1994. Effects of spaceflight on the number of rat peripheral blood leukocytes and lymphocyte subsets. Journal of Leukocyte Biology 55(209):213.
  • Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. 2005. Key gravity-sensitive signaling pathways drive T cell activation. Federation of American Societies for Experimental Biology Journal 19:2020–2022.
  • Cogoli A, Tschopp A, Fuchs-Bislin P. 1984. Cell sensitivity to gravity. Science 225:228–230.
  • Gridley DS, Pecaut MJ, Nelson GA. 2002. Total-body irradiation with high-LET particles: Acute and chronic effects on the immune system. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 282:R677–688.
  • Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson VL, Pecaut MJ. 2009. Spaceflight effects on T lymphocyte distribution, function and gene expression. Journal of Applied Physiology 106:194–202.
  • Hughes-Fulford M, Sugano E, Schopper T, Li CF, Boonyaratanakornkit JB, Cogoli A. 2005. Early immune response and regulation of IL-2 receptor subunits. Cellular Signaling 17:1111–1124.
  • Kajioka EH, Gheorghe C, Andres ML, Abell GA, Folz-Holbeck, Slater JM, Nelson GA, Gridley DS. 1999. Effects of proton and gamma radiation on lymphocyte populations and acute response to antigen. In Vivo 13:525–533.
  • Lange RD, Andrews RB, Gibson LA, Wright P, Dunn CD, Jones JB. 1985. Hematologic parameters of astrorats flown on SL-3. Physiologist 28:S195–196.
  • Maino VC, Suni MA, Ruitenberg JJ. 1995. Rapid flow cytometric method for measuring lymphocyte subset activation. Cytometry 20:127–133.
  • Meehan RT, Neale LS, Kraus ET, Stuart CA, Smith ML, Cintron NM, Sams CF. 1992. Alteration in human mononuclear leucocytes following space flight. Immunology 76:491–497.
  • Mills PJ, Meck JV, Waters WW, D'Aunno D, Ziegler MG. 2001. Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration. Psychosomatic Medicine 63:886–890.
  • Morey-Holton ER, Globus RK. 2002. Hindlimb unloading rodent model: Technical aspects. Journal of Applied Physiology 92:1367–1377.
  • Nash PV, Mastro AM. 1992. Variable lymphocyte responses in rats after space flight. Experimental Cell Research 202:125–131.
  • Nash PV, Bour BA, Mastro AM. 1991. Effect of hindlimb suspension simulation of microgravity on in vitro immunological responses. Experimental Cell Research 195:353–360.
  • Pecaut MJ, Nelson GA, Peters LL, Kostenuik PJ, Bateman TA, Morony S, Stodieck LS, Lacey DL, Simske SJ, Gridley DS. 2003. Genetic models in applied physiology: Selected contribution: Effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions. Journal of Applied Physiology 94:2085–2094.
  • Shearer WT, Zhang S, Reuben JM, Lee BN, Butel JS. 2005. Effects of radiation and latent virus on immune responses in a space flight model. Journal of Allergy and Clinical Immunology 115: 1297–1303.
  • Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, . 2009. Immune responses in adult female volunteers during the bed-rest model of spaceflight: Antibodies and cytokines. Journal of Allergy and Clinical Immunology 123:900–905.
  • Simms PE, Ellis TM. 1996. Utility of flow cytometric detection of CD69 expression as a rapid method for determining poly- and oligoclonal lymphocyte activation. Clinical and Diagnostic Laboratory Immunology 3:301–304.
  • Sonnenfeld G, Shearer WT. 2002. Immune function during space flight. Nutrition 18:899–903.
  • Taylor GR. 1993. Immune changes during short-duration missions. Journal of Leukocyte Biology 54:202–208.
  • Taylor GR, Neale LS, Dardano JR. 1986. Immunological analyses of U.S. Space Shuttle crewmembers. Aviation, Space and Environmental Medicine 57:213–217.
  • Wagner EB, Granzella NP, Saito H, Newman DJ, Young LR, Bouxsein ML. 2010. Partial weight suspension: A novel murine model for investigating adaptation to reduced musculoskeletal loading. Journal of Applied Physiology 109:350–357.
  • Wambi C, Sanzari J, Wan XS, Nuth M, Davis J, Ko YH, Sayers CM, Baran M, Ware JH, Kennedy AR. 2008. Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiation Research 169:384–396.
  • Wambi CO, Sanzari JK, Sayers CM, Nuth M, Zhou Z, Davis J, Finnberg N, Lewis-Wambi JS, Ware JH, El-Deiry WS, Kennedy AR. 2009. Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival. Radiation Research 172:175–186.
  • Wei LX, Zhou JN, Roberts AI, Shi YF. 2003. Lymphocyte reduction induced by hindlimb unloading: Distinct mechanisms in the spleen and thymus. Cell Research 13:465–471.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.