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Research Article

Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity

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Pages 433-444 | Received 17 Jul 2012, Accepted 14 Jan 2013, Published online: 19 Mar 2013

References

  • Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P. 1998. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393:805–809.
  • Avila MA, Otero G, Cansado J, Dritschilo A, Velasco JA, Notario V. 1993. Activation of phospholipase D participates in signal transduction pathways responsive to gamma-radiation. Cancer Research 53:4474–4476.
  • Bakkenist CJ, Kastan MB. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499–506.
  • Bamburg JR, McGough A, Ono S. 1999. Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends in Cell Biology 9:364–370.
  • Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, Chang S, Ferguson DO. 2008. Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 135:85–96.
  • Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. 2001. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. The Journal of Biological Chemistry 276:42462–42467.
  • Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A. 2003. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nature Cell Biology 5:675–679.
  • Cooper JA. 1987. Effects of cytochalasin and phalloidin on actin. The Journal of Cell Biology 105:1473–1478.
  • Czornak K, Chughtai S, Chrzanowska KH. 2008. Mystery of DNA repair: The role of the MRN complex and ATM kinase in DNA damage repair. Journal of Applied Genetics 49:383–396.
  • Fittkau M, Gerlach R, Schmoll HJ. 2001. Protective effect of oral phosphatidylcholine on radiation-induced release of intestinal peptidases in rats. Journal of Cancer Research and Clinical Oncology 127:444–448.
  • Friesner JD, Liu B, Culligan K, Britt AB. 2005. Ionizing radiation- dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related. Molecular Biology of the Cell 16:2566–2576.
  • Gillett GT, Fox MF, Rowe PS, Casimir CM, Povey S. 1996. Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. Annals of Human Genetics 60:201–211.
  • Gu Y, Jin S, Gao Y, Weaver DT, Alt FW. 1997. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proceedings of the National Academy of Sciences of the USA 94:8076–8081.
  • Han L, Stope MB, de Jesus ML, Oude Weernink PA, Urban M, Wieland T, Rosskopf D, Mizuno K, Jakobs KH, Schmidt M. 2007. Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin. The EMBO Journal 26:4189–4202.
  • Harima Y, Sawada S, Miyazaki Y, Kin K, Ishihara H, Imamura M, Sougawa M, Shikata N, Ohnishi T. 2003. Expression of Ku80 in cervical cancer correlates with response to radiotherapy and survival. American Journal of Clinical Oncology 26:e80–85.
  • Harrington K, Jankowska P, Hingorani M. 2007. Molecular biology for the radiation oncologist: The 5Rs of radiobiology meet the hallmarks of cancer. Clinical Oncology: A Journal of the Royal College of Radiologists 19:561–571.
  • Hsu FF, Lin TY, Chen JY, Shieh SY. 2010. p53-mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control. Oncogene 29:2864–2876.
  • Jovceva E, Larsen MR, Waterfield MD, Baum B, Timms JF. 2007. Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis. Journal of Cell Science 120:1888–1897.
  • Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, et al. 2006. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 439:497–501.
  • Lee JH, Paull TT. 2007. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 26:7741–7748.
  • Lee YJ, Sheu TJ, Keng PC. 2005. Enhancement of radiosensitivity in H1299 cancer cells by actin-associated protein cofilin. Biochemical and Biophysical Research Communications 335:286–291.
  • Lieber MR. 2010. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annual Review of Biochemistry 79:181–211.
  • Nagai S, Moreno O, Smith CA, Ivanchuk S, Romagnuolo R, Golbourn B, Weeks A, Seol HJ, Rutka JT. 2011. Role of the cofilin activity cycle in astrocytoma migration and invasion. Genes & Cancer 2:859–869.
  • Nagaoka R, Abe H, Obinata T. 1996. Site-directed mutagenesis of the phosphorylation site of cofilin: Its role in cofilin-actin interaction and cytoplasmic localization. Cell Motility and the Cytoskeleton 35:200–209.
  • Nebl G, Meuer SC, Samstag Y. 1996. Dephosphorylation of serine 3 regulates nuclear translocation of cofilin. The Journal of Biological Chemistry 271:26276–26280.
  • Nishita M, Wang Y, Tomizawa C, Suzuki A, Niwa R, Uemura T, Mizuno K. 2004. Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. The Journal of Biological Chemistry 279:7193–7198.
  • Olive PL, MacPhail SH. 1992. Radiation-induced DNA unwinding is influenced by cell shape and trypsin. Radiation Research 130:241–248.
  • Park MS. 1995. Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells. The Journal of Biological Chemistry 270:15467–15470.
  • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. 2000. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Current Biology 10:886–895.
  • Seluanov A, Mao Z, Gorbunova V. 2010. Analysis of DNA double-strand break (DSB) repair in mammalian cells. Journal of Visualized Experiments: JoVE 43:2002.
  • Spector I, Shochet NR, Blasberger D, Kashman Y. 1989. Latrunculins – novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D. Cell Motility and the Cytoskeleton 13:127–144.
  • Steel GG, McMillan TJ, Peacock JH. 1989. The 5Rs of radiobiology. International Journal of Radiation Biology 56:1045–1048.
  • Stiff T, O’Driscoll M, Rief N, Iwabuchi K, Lobrich M, Jeggo PA. 2004. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Research 64:2390–2396.
  • Taki T, Ohnishi T, Yamamoto A, Hiraga S, Arita N, Izumoto S, Hayakawa T, Morita T. 1996. Antisense inhibition of the RAD51 enhances radiosensitivity. Biochemical and Biophysical Research Communications 223:434–438.
  • Tsai CH, Chiu SJ, Liu CC, Sheu TJ, Hsieh CH, Keng PC, Lee YJ. 2009. Regulated expression of cofilin and the consequent regulation of p27(kip1) are essential for G(1) phase progression. Cell Cycle 8:2365–2374.
  • Vispe S, Cazaux C, Lesca C, Defais M. 1998. Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation. Nucleic Acids Research 26:2859–2864.
  • Walworth NC, Bernards R. 1996. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271:353–356.
  • Wang W, Eddy R, Condeelis J. 2007. The cofilin pathway in breast cancer invasion and metastasis. Nature Reviews. Cancer 7:429–440.
  • Wang W, Mouneimne G, Sidani M, Wyckoff J, Chen X, Makris A, Goswami S, Bresnick AR, Condeelis JS. 2006. The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors. The Journal of Cell Biology 173:395–404.
  • Yahara I, Aizawa H, Moriyama K, Iida K, Yonezawa N, Nishida E, Hatanaka H, Inagaki F. 1996. A role of cofilin/destrin in reorganization of actin cytoskeleton in response to stresses and cell stimuli. Cell Structure and Function 21:421–424.
  • Yamaguchi H. 2012. [Molecular mechanisms of invadopodium formation by cancer cells]. Seikagaku. The Journal of Japanese Biochemical Society 84:35–38.
  • Yan H, Yang K, Xiao H, Zou YJ, Zhang WB, Liu HY. 2012. Over- expression of cofilin-1 and phosphoglycerate kinase 1 in astrocytomas involved in pathogenesis of radioresistance. CNS Neuroscience & Therapeutics 18:729–736.
  • Yarmola EG, Somasundaram T, Boring TA, Spector I, Bubb MR. 2000. Actin-latrunculin A structure and function. Differential modulation of actin-binding protein function by latrunculin A. The Journal of Biological Chemistry 275:28120–28127.

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