DNA-dependent protein kinase and its inhibition in support of radiotherapy

References

• An J, Quing-Zhi X, Sui JL, Bai B Zhou PK. 2005. Downregulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cells. International Journal of Cancer 117:531–537.
   PubMed Web of Science ®Google Scholar
• An J, Huang Y, Xu Q, Zhou L, Shang Z, Huang B, Wang Y, Liu X, Wu D, Zhou P. 2010. DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Molecular Biology 11:18.
   PubMed Web of Science ®Google Scholar
• Bakkenist CJ, Kastan MB. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499–506.
   PubMed Web of Science ®Google Scholar
• Bardos J, Shea K, Parveen N, Peacock M, Deacon W, Cranston A, Albertella M, Menear K, Smith G, Martin N. 2009. Radio- and chemosensitization through inhibition of DNA-PK by KU0060648. Molecular Cancer Therapy 8:A116.
   Web of Science ®Google Scholar
• Bartek J, Bartkova J, Lukas J. 2007. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 26:7773–7779.
   PubMed Web of Science ®Google Scholar
• Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J. 2006. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. Journal of Cell Biology 173:195–206.
   PubMed Web of Science ®Google Scholar
• Bekker-Jensen S, Mailand N. 2010. Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair 9:1219–1228.
   PubMed Web of Science ®Google Scholar
• Bennett CB, Lewis AL, Baldwin KK, Resnick MA. 1993. Lethality induced by a 1017 single site-specific double-strand break in a dispensable yeast plasmid, 1018. Proceedings of the National Academy of Sciences of the USA 90:5613–5617.
   PubMed Web of Science ®Google Scholar
• Bogue MA, Jhappan C, Roth DB. 1998. Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK independent pathways for both signal and coding joint formation. Proceedings of the National Academy of Sciences of the USA 95:15559–15564.
   PubMed Web of Science ®Google Scholar
• Boyer J, Rohleder K, Ketner G. 1999. The adenovirus early region 434 kDa and 11kDa oncoproteins inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase. Virology 263:307–312.
   PubMed Web of Science ®Google Scholar
• Boyle P, Levin B. 2008. World cancer report 2008. Lyon: International Agency for Research on Cancer; Geneva: Distributed by WHO Press.
   Google Scholar
• Burdak-Rothkamm S, Prise KM. 2009. New molecular targets in radiotherapy: DNA damage signalling and repair in targeted and non- targeted cells. European Journal of Pharmacology 625:151–155.
   PubMed Web of Science ®Google Scholar
• Cano C, Barbeau OR, Bailey Ch, Cockcroft X-L, Curtin NJ, Duggan H, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Knights Ch, Menear KA, Newell DR, Richardson CJ, Smith GCM, Spittle B, Griffin RJ. 2010. DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of Quinolin-4-one and Pyridopyrimidin-4-one surrogates for the Chromen-4-one chemotype. Journal of Medicinal Chemistry 53:8498–8507.
   PubMed Web of Science ®Google Scholar
• Chan DW, Lees-Miller S. 1996. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. The Journal of Biological Chemistry 271:8936–8941.
   PubMed Web of Science ®Google Scholar
• Cheng JC, Moore TB, Sakamoto KM. 2003. RNA interference and human disease. Molecular Genetics and Metabolism 80:121–128.
   PubMed Web of Science ®Google Scholar
• Clapham KM, Bardos J, Finlay MRV, Golding BT, Griffen EJ, Griffin RJ, Hardcastle IR, Menear KA, Ting A, Turner P, Young GL, Cano C. 2011. DNA-dependent protien kinase (DNA-PK) inhibitors: Structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain. Bioorganic & Medicinal Chemistry Letters 21:966–970.
   PubMed Web of Science ®Google Scholar
• Collis JS, DeWeese TL, Jeggo AP, Parker AR. 2005. The live and death of DNA-PK. Oncogene 24:949–961.
   PubMed Web of Science ®Google Scholar
• DiBiase S, Zeng ZCH, Chen R, Hyslop T, Curran WJ, Iliakis G. 2000. DNA-dependent protein kinase stimulates an independently active nonhomologous end-joining apparatus. Cancer Research 60:1245–1253.
   PubMed Web of Science ®Google Scholar
• Dobbs TA, Tainer JA, Lees-Miller S. 2010. A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair 9:1307–1314.
   PubMed Web of Science ®Google Scholar
• Dutreix M, Cosset JM, Sun JS. 2010. Molecular therapy in support to radiotherapy. Mutation Research 704:182–189.
   PubMed Web of Science ®Google Scholar
• Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494–98.
   Google Scholar
• Fattah KR, Ruis BL, Hendrickson EA. 2008. Mutations to Ku reveal differences in human somatic cell lines. DNA Repair 7:762–764.
   PubMed Web of Science ®Google Scholar
• Fuhrman CB, Kilgore J, LaCoursiere YD, Lee CM, Milash BA, Soisson AP, Zempolich KA. 2008. Radiosensitization of cervical cancer cells via double-strand DNA break repair inhibition. Gynecologic Oncology 110:93–98.
   PubMed Web of Science ®Google Scholar
• Galanis E, Vile R, Russell SJ. 2001. Delivery systems intended for in vivo gene therapy of cancer: Targeting and replication competent viral vectors. Critical Reviews in Oncology/Hematology 38:177–192.
   PubMed Web of Science ®Google Scholar
• Gupta AK, Cerniglia GJ, Mick R, Ahmed MS, Bakanauskas VJ, Muschel RJ, McKenna WG. 2003. Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. International Journal of Radiation Oncology Biology Physics 56: 846–853.
   PubMed Web of Science ®Google Scholar
• Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, Phipps BM, Rambo RP, Hura GL, Pelikan M, So S, Abolfath RM, Chen DJ, Lees-Miller SP, Tainer JA. 2010. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. The Journal of Biological Chemistry 285:1414–1423.
   PubMed Web of Science ®Google Scholar
• Hardcastle IR, Cockroft X, Curtin NJ, et al. 2005. Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. Journal of Medicinal Chemistry 48:7829–7846.
   PubMed Web of Science ®Google Scholar
• Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. 2004. Identification and characterization of a novel and specific inhibitor of the Ataxia-telangiectasia mutated kinase ATM. Cancer Research 64:9152–9159.
   PubMed Web of Science ®Google Scholar
• Hill R, Lee PWK. 2010. The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?Cell Cycle 9:3460–3469.
   PubMed Web of Science ®Google Scholar
• Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G. 2004. Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenetic and Genome Research 104:14–20.
   PubMed Web of Science ®Google Scholar
• Iliakis G. 2009. Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence. Radiotherapy and Oncology 92:310–315.
   PubMed Web of Science ®Google Scholar
• Jeggo P, Lavin MF. 2009. Cellular radiosensitivity: How much better do we understand it?International Journal of Radiation Biology 85:1061–1081.
   PubMed Web of Science ®Google Scholar
• Jeggo PA. 1998. Identification of genes involved in repair of DNA double-strand breaks in mammalia cells. Radiation Research 150:80–91
   PubMed Web of Science ®Google Scholar
• Jiang H, Reinhardt CH, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB, Hemann MT. 2010. The combined status of ATM and p53 link tumour development with therapeutic response. Genes Development 23:1895–1909.
   Web of Science ®Google Scholar
• Kim C, Park S, Lee S. 2002. A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation. The Journal of Pharmacology and Experimental Therapeutics 303:753–759.
   PubMed Web of Science ®Google Scholar
• Mao Z, Bozzella M, Seluanov A, Gorbunova V. 2008. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 7:2902–2906.
   PubMed Web of Science ®Google Scholar
• Marcon E, Moens PB. 2005. The evolution of meiosis: Recruitment and modification of somatic DNA-repair proteins. BioEssays 27: 795–808.
   PubMed Web of Science ®Google Scholar
• Martin NMB. 2001. DNA repair inhibition and cancer therapy. Journal of Photochemistry and Photobiology 63:162–170.
   Web of Science ®Google Scholar
• Mikusová V, Tichý A, Řezáčová M, Vávrová J. 2011. Mitoxantrone in combination with a DNA-PK inhibitor: Possible therapy of promyelocytic leukaemia resistant forms. Folia Biologica (Praha) 57:200–205.
   PubMed Web of Science ®Google Scholar
• Muller C, Christodoupoulos G, Salles B, Panasci L. 1998. DNA-dependent protein kinase activity correlates with clinical and in vitro senzitivity of chronic lymphocytic leukaemia lymphocytes to nitrogen mustards. Blood 92:2213–2219.
   PubMed Web of Science ®Google Scholar
• Munck JM, Batey MA, Zhao Y, Jenkins H, Richardson CJ, Cano C, Tavecchio M, Barbeau J, Bardos J, Cornell L, Griffin RJ, Menear K, Slade A, Thommes P, Martin NMB, Newell DR, Smith GC, Curtin NJ. 2012. Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. Molecular Cancer Therapeutics 11:1789–98.
   PubMed Web of Science ®Google Scholar
• Neal JA, Meek K. 2011. Choosing the right path: Does DNA-PK help the decision?Mutation Research 711:73–86.
   PubMed Web of Science ®Google Scholar
• Nutley BP, Smith NF, Hayes A, Kelland LR, Brunton L, Golding BT, Smith GCM, Martin NBM, Workman P, Raynaud FI. 2005. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. British Journal of Cancer 93:1011–1018.
   PubMed Web of Science ®Google Scholar
• Pawelczak KS, Turchi JJ. 2010. Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair. DNA Repair 9:670–677.
   PubMed Web of Science ®Google Scholar
• Payne SL, Rodriguez-Aristegui S, Bardos J, Cano C, Golding BT, Hardcastle IR, Peacock M, Parveen N, Griffin RJ. 2010. Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors. Bioorganic & Medicinal Chemistry Letters 20:3649–3653.
   PubMed Web of Science ®Google Scholar
• Peng Y, Zhang Q, Nagasawa H, Okayasu R, Liber HL, Bedford JS. 2002. Silencing Expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Research 62:6400–6404.
   PubMed Web of Science ®Google Scholar
• Quanz M, Chassoux D, Berthault N, Agrario C, Sun JS, Dutreix M. 2009a. Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response. Public Library of Science One 4:e6298.
   Google Scholar
• Quanz M, Berhault N, Roulin C, Roy M, Herbette A, Agrario C, Alberti C, Josserand V, Coll JL, Sastre-Garau X, Cosset JM, Larue L, Sun JS, Dutreix M. 2009b. Small-molecule drugs mimicking DNA-damage: A new strategy for sensitizing tumours to radiotherapy. Clinical Cancer Research 15:1308–1316.
   PubMed Web of Science ®Google Scholar
• Rainey MD, Charlton ME, Stanton RV, Kastan MB. 2008. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Research 68:7466–7474.
   PubMed Web of Science ®Google Scholar
• Rao DD, Vorhies JS, Senzer N, Nemunaitis J. 2009. siRNA vs. shRNA: Similarities and differences. Advanced Drug Delivery Reviews 61:746–759.
   PubMed Web of Science ®Google Scholar
• Rube CE, Fricke A, Wendorf J, Stutzel A, Kuhne M, Ong MF, Lipp P, Rube CH. 2010. Accumulation of DNA double-strand breaks in normal tissues after fractionated irradiation. International Journal of Radiation Oncology Biology Physics 76:1206–1213.
   PubMed Web of Science ®Google Scholar
• Řezáčová M, Rudolfová G, Tichý A, Bačíková A, Muthná D, Havelek R, Vávrová J, Odrážka K, Lukášová E, Kozubek S. 2011. Accumulation of DNA damage and cell death after fractionated irradiation. Radiation Research 175:708–718.
   PubMed Web of Science ®Google Scholar
• Saravanan K, Albertella M, Cano C, Curtin NJ, Frigerio M, Golding BT, Haggerty K, Hardcastle IR, Hummersone M, Menear K, Newell DR, Rennison T, Richardson C, Rigoreau L, Rodriguez-Aristegui S, Smith GCM, Griffin RJ. 2008. Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research San Diego, CA: AACR.
   Google Scholar
• Sarkaria JN, Tibbets RS, Busby EC, Kennedy AP, Hill DE, Abraham RT. 1998. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Research 58:4375–4382.
   PubMed Web of Science ®Google Scholar
• Sarkaria JN, Busby EC, Tibbets RS, Roos P, Taya Y, Karnitz LM, Abraham RT. 1999. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Research 59:4375–4382.
   PubMed Web of Science ®Google Scholar
• Senra JM, Tefler BA, Cherry KE, McCrudden CM, Hirst DG, O’Connor MJ, Wedge SR, Stradford IJ. 2011. Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumour Xenograft. Molecular Cancer Therapeutics 10:1949–1958.
   PubMed Web of Science ®Google Scholar
• Shimura T, Kakuda S, Ochiai Y, Nagakawa H, Kuwahara Y, Takai Y, Kobayashi J, Komatsu K, Fukumoto M. 2010. Acquired radioresistance of human tumour cells by DNA-PK/AKT/GSK3β-mediated cyclin D1 overexpression. Oncogene 29:4826–4837.
   PubMed Web of Science ®Google Scholar
• Stein RC. 2005. Prospect for phosphoinositide 3-kinase inhibition as a cancer treatment endocrine-related cancer. Radiosensitisation and Radiotheraphy Oncology 74:117–129.
   PubMedGoogle Scholar
• Szkanderová S, Vávrová J, Řezáčová M, Vokurková D, Pavlová S, Smardová J, Stulík J. 2003. Gamma irradiation results in phosphorylation of p53 at serine-392 in human T-lymphocyte leukaemia cell line MOLT-4. Folia Biologia (Praha) 49:191–196.
   PubMed Web of Science ®Google Scholar
• Takata M, Sasaki MS, Sonoda E, Morrison C, Yamaguchi-Iwai Y, Shinohara A, Takeda S. 1998. Homologous recombination and nonhomologous end joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO Journal 17:5497–5508.
   PubMed Web of Science ®Google Scholar
• Tichý A, Záškodová D, Řezáčová M, Vávrová J, Vokurková D, Pejchal J, Vilasová Z, Cerman J, Ossterreicher J. 2007. Gamma-radiation-induced ATM-dependent signalling in human T-lymphocyte leukemic cells, MOLT-4. Acta Biochimica Polonica 54:281–287.
   PubMed Web of Science ®Google Scholar
• Tichý A, Záškodová D, Vávrová J, Pejchal J, Řezáčová M. 2011. Caffeine-suppressed ATM pathway leads to decreased p53 phosphorylation and increased programmed cell death in gamma-irradiated leukaemic MOLT-4 cells. Journal of Applied Biomedicine 9:49–56.
   Web of Science ®Google Scholar
• Tichý A, Novotná E, Ďurišová K, Šalovská B, Sedlaříková R, Pejchal J, Zárybnická L, Vávrová J, Šinkorová Z, Řezácová M. 2012. Radio-sensitization of human leukaemic MOLT-4 cells by DNA-dependent protein kinase inhibitor, NU7026. Acta Medica 55:66–73.
   Google Scholar
• Valerie K, Povirk LF. 2003. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22:5792–5812.
   PubMed Web of Science ®Google Scholar
• Van der Burg M, Ijspeert H, Verkaik RS, Turul T, et al. 2009. A DNA-PKcs mutation in a radiosensitive T-B-SCID patient inhibits Artemis activation and nonhomologous end-joining. Journal of Clinical Investigation 119: 91–98.
   PubMed Web of Science ®Google Scholar
• Vávrová J, Mareková-Řezáčová M, Vokurková D, Szkanderová S, Psutka J. 2003. Caffeine induces a second wave of apoptosis after low dose-rate gamma radiation of HL-60 cells. Radiation and Environmental Biophysics 42:193–199.
   PubMed Web of Science ®Google Scholar
• Veuger SJ, Curtin NJ, Richardson CJ, et al. 2003. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose)polymerase 1. Cancer Research 63:6008–6015.
   PubMed Web of Science ®Google Scholar
• Vilasová Z, Řezáčová M, Vávrová J, Tichý A, Vokurková D. 2008. Changes in phosphorylation of histone H2A.X and p53 in response of peripheral blood lymphocytes to gamma irradiation. Acta Biochimica Polonica 55:381–90.
   PubMed Web of Science ®Google Scholar
• Vilenchik MM, Knudson AG. 2003. Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer. Proceedings of the National Academy of Sciences of the USA 100:12871–12876.
   PubMed Web of Science ®Google Scholar
• Vlahos CJ, Matter WF, Hui KY, Brown RF. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry 269: 5241–5248.
   PubMed Web of Science ®Google Scholar
• Wang H, Zeng ZC, Perrault AR, Cheng X, Qin W, Iliakis G. 2001. Genetic evidence for the involvement of DNA ligase IV in the DNA-PK dependent pathway of non-homologous end joining in mammalian cells. Nucleic Acids Research 29:1653–1660.
   PubMed Web of Science ®Google Scholar
• Wang Y, Ghosh G, Hendrickson EA. 2009. Ku86 represses lethal telomere events in human somatic cells. Proceedings of the National Academy of Sciences of the USA 106:12430–12435.
   PubMed Web of Science ®Google Scholar
• White JS, Choi S, Bakkenist CJ. 2008. Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity. Cell Cycle 7:1277–1284.
   PubMed Web of Science ®Google Scholar
• White JS, Choi S, Bakkenist CJ. 2010. Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange. Science Signalling 3:ra44.
   PubMed Web of Science ®Google Scholar
• Willmore E, de Caux S, Sunter NJ, Tilby MJ, Jackson GH, Austin CA, Durkacz BW. 2004. A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukaemia. Blood 103:4659–4665.
   PubMed Web of Science ®Google Scholar
• Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo Y, Mao H, Hao C, Olson JJ, Curran WJ, Wang Y. 2010. Targeting DNA-PKcs and ATM with miR-101 sensitizes tumours to radiation. PLoS ONE 5:e11397.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhou J, Cao X, Zhang Q, Lim CHUK, Ullrich R, Bailey SM, Liber HL. 2007. Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells. Cancer Letters 250:63–73.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Huw DT, Batey MA, Cowell IG, Richardson CJ, Griffin RJ, Calvert AH, Newell DR, Smith GCM. 2006. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Research 66:5354–5362.
   PubMed Web of Science ®Google Scholar