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RADIATION RESPONSE OF TRANSCRIPTIONALLY RESPONSIVE GENES

High and low dose responses of transcriptional biomarkers in ex vivo X-irradiated human blood

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Pages 512-522 | Received 19 Oct 2012, Accepted 16 Jan 2013, Published online: 27 Feb 2013

References

  • Amundson SA, Bittner M, Meltzer P, Trent J, Fornace AJ Jr. 2001. Induction of gene expression as a monitor of exposure to ionising radiation. Radiation Research 156:657–661.
  • Amundson SA, Do KT, Fornace AJ Jr. 1999. Induction of stress genes by low doses of gamma rays. Radiation Research 152:225–231.
  • Amundson SA, Do KT, Shahab S, Bittner M, Meltzer P, Trent J, Fornace AJ Jr. 2000. Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionising radiation. Radiation Research 154:342–346.
  • Amundson SA, Grace MB, McLeland CB, Epperly MW, Yeager A, Zhan Q, Greenberger JS, Fornace AJ Jr. 2004. Human in vivo radiation-induced biomarkers: Gene expression changes in radiotherapy patients. Cancer Research 64:6368–6371.
  • Angel P, Pöting A, Mallick U, Rahmsdorf HJ, Schorpp M, Herrlich P. 1986. Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. Molecular Cell Biology 6(5):1760–1766.
  • Badie C, Dziwura S, Raffy C, Tsigani T, Alsbeih G, Moody J, Finnon P, Levine E, Scott D, Bouffler S. 2008. Aberrant CDKN1A transcriptional response associates with abnormal sensitivity to radiation treatment. British Journal of Cancer 98:1845–1851.
  • Badie C, Itzhaki JE, Sullivan MJ, Carpenter AJ, Porter AC. 2000. Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells. Molecular Cell Biology 20:2358–2366.
  • Belloni P, Meschini R, Palitti F. 2008. Effects of storage conditions of human whole blood on the viability of lymphocytes. International Journal of Radiation Biology 84:613–619.
  • Berglund SR, Rocke DM, Dai J, Schwietert CW, Santana A, Stern RL, Lehmann J, Hartmann Siantar CL, Goldberg Z. 2008. Transient genome-wide transcriptional response to low-dose ionising radiation in vivo in humans. International Journal of Radiation Oncology Biology Physics 70:229–234.
  • Blakely WF, Salter CA, Prasanna PG. 2005. Early-response biological dosimetry-recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Physics 9:494–504.
  • Chaudhry MA. 2008. Biomarkers for human radiation exposure. Journal of Biomedical Science 15:557–563.
  • Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C, Cheng JF, Chen DJ. 2005. Gene expression profiles of normal human fibroblasts after exposure to ionising radiation: A comparative study of low and high doses. Radiation Research 164:17–26.
  • Dressman HK, Muramoto GG, Chao NJ, Meadows S, Marshall D, Ginsburg GS, Nevins JR, Chute JP. 2007. Gene expression signatures that predict radiation exposure in mice and humans. PLOS Medicine 4:e106.
  • Fachin AL, Mello SS, Sandrin-Garcia P, Junta CM, Donadi EA, Passos GA, Sakamoto-Hojo ET. 2007. Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays. Radiation Research 168:650–665.
  • Filiano AN, Fathallah-Shaykh HM, Fiveash J, Gage J, Cantor A, Kharbanda S, Johnson MR. 2011. Gene expression analysis in radiotherapy patients and C57BL/6 mice as a measure of exposure to ionising radiation. Radiation Research 176:49–61.
  • Fornace AJ Jr, Alamo I Jr, Hollander MC. 1988. DNA-damage inducible transcripts in mammalian cells. Proceedings of the National Academy of Sciences of the USA 85:8800–8804.
  • Fornace AJ, Amundson SA, Do KT, Meltzer P, Trent J, Bittner M. 2002. Stress-gene induction by low-dose gamma irradiation. Military Medicine 167:13–15.
  • Gad A, Schellander K, Hoelker M, Tesfaye D. 2012. Transcriptome profile of early mammalian embryos in response to culture environment. Animal Reproduction Science 76–83.
  • Goldberg Z, Schwietert CW, Lehnert B, Stern R, Nami I. 2004. Effects of low-dose ionising radiation on gene expression in human skin biopsies. International Journal of Radiation Oncology Biology 58:567–574.
  • Grace MB, McLeland CB, Blakely WF. 2002. Real-time quantitative RT-PCR assay of GADD45 gene expression changes as a biomarker for radiation biodosimetry. International Journal of Radiation Biology 8:1011–1021.
  • Hall EJ, Brenner DJ. 2008. Cancer risks from diagnostic radiology. British Journal of Radiology 81:362–378.
  • International Atomic Energy Agency (IAEA). 2001. Cytogenetic analysis for radiation dose assessment: A manual. Technical reports Series No. 405. Vienna: IAEA.
  • Joiner MC, Thomas RA, Grever WE, Smolinski JM, Divine GW, Konski AA, Auner GW, Tucker JD. 2011. Developing point of care and high-throughput biological assays for determining absorbed radiation dose. Radiation Oncology 101:233–236.
  • Kabacik S, Mackay A, Tamber N, Manning G, Finnon P, Ashworth A, Bouffler S, Badie C. 2011a. Gene expression following ionising radiation: Identification of biomarkers for dose estimation and prediction of individual response. International Journal of Radiation Biology 87:115–129.
  • Kabacik S, Ortega-Molina A, Efeyan A, Finnon P, Bouffler S, Serrano M, Badie C. 2011b. A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity. Cell Cycle 10:1152–1161.
  • Kenyon CJ, Walker GC. 1980. DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli. Proceedings of the National Academy of Sciences of the USA 77:2819–2823.
  • Long XH, Zhao ZQ, He XP, Wang HP, Xu QZ, An J, Bai B, Sui JL, Zhou PK. 2007. Dose-dependent expression changes of early response genes to ionising radiation in human lymphoblastoid cells. International Journal of Molecular Medicine 19:607–615.
  • Manning G, Kabacik S, Finnon P, Paillier F, Bouffler S, Badie C. 2011. Assessing a new gene expression analysis technique for radiation biodosimetry applications. Radiation Measurements 46:1014–1018.
  • Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP. 2010. Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. PLoS One 5:e11535.
  • Melanson BD, Bose R, Hamill JD, Marcellus KA, Pan EF, McKay BC. 2011. The role of mRNA decay in p53-induced gene expression. RNA 17:2222–2234.
  • Mezentsev A, Amundson SA. 2011. Global gene expression responses to low- or high-dose radiation in a human three-dimensional tissue model. Radiation Research 175:677–688.
  • Oh JH, Wong HP, Wang X, Deasy JO. 2012. A bioinformatics filtering strategy for identifying radiation response biomarker candidates. PLoS One 7:e38870.
  • Paul S, Amundson SA. 2008. Development of gene expression signatures for practical radiation biodosimetry. International Journal of Radiation Oncology Biology Physics 71:1236–1244.
  • Paul S, Barker CA, Turner HC, McLane A, Wolden SL, Amundson SA. 2011. Prediction of in vivo radiation dose status in radiotherapy patients using ex vivo and in vivo gene expression signatures. Radiation Research 175:257–265.
  • Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de González A. 2012. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: A retrospective cohort study. The Lancet 380:499–505.
  • Ruby SW, Szostak JW. 1985. Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Molecular Cell Biology 5:75–84.
  • Shahdadfar A, Frønsdal K, Haug T, Reinholt FP, Brinchmann JE. 2005. In vitro expansion of human mesenchymal stem cells: Choice of serum is a determinant of cell proliferation, differentiation, gene expression and transcriptome stability. Stem Cells 23:1357–1366.
  • United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). 2006. Effects of Ionising Radiation. UNSCEAR Report.
  • Woloschak GE, Chang Liu C-M, Shearin-Jones P, Jones CA. 1990. Modulation of gene expression in Syrian hamster embryo cells following ionising radiation. Cancer Research 50:339–344.
  • Woloschak GE, Chang-Liu CM. 1990. Differential modulation of specific gene expression following high- and low-LET radiations. Radiation Research 124:183–187.
  • Wyrobek AJ, Manohar CF, Krishnan VV, Nelson DO, Furtado MR, Bhattacharya MS, Marchetti F, Coleman MA. 2011. Low dose radiation response curves, networks and pathways in human lymphoblastoid cells exposed from 1 to 10cGy of acute gamma radiation. Mutation Research 17:119–130.
  • Yin E, Nelson DO, Coleman MA, Peterson LE, Wyrobek AJ. 2003. Gene expression changes in mouse brain after exposure to low-dose ionising radiation. International Journal of Radiation Biology 79:759–775.

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