The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation

References

• An J, Huang YC, Xu QZ, Zhou LJ, Shang ZF, Huang B, Wang Y, Liu XD, Wu DC, Zhou PK. 2010. DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cells cycle progression. BMC Molecular Biology 11:18.
   PubMed Web of Science ®Google Scholar
• Aquino R, Papaccio G, Laino G, Graziano A. 2008. Dental pulp stem cells: A promising tool for bone regeneration. Stem Cell Reviews 4:21–26.
   PubMedGoogle Scholar
• Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597–601.
   PubMed Web of Science ®Google Scholar
• Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. 2001. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. Journal of Biological Chemistry 45:42462–42467.
   Google Scholar
• Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. 1998. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677–1679.
   PubMed Web of Science ®Google Scholar
• Cazzalini O, Scovassi AI, Savio M, Stivala LA, Prosperi E. 2010. Multiple roles of the cell cycle inhibitor p21 (CDKN1A) in the DNA damage response. Mutation Research 704:12–20.
   PubMed Web of Science ®Google Scholar
• Chen MF, Lin CT, Chen WC, Yang CT, Chen CC, Liao SK, Liu JM, Lu CH, Lee KD. 2006. The sensitivity of human mesenchymal stem cells to ionizing radiation. International Journal of Radiation Oncology, Biology, Physics 66:244–253.
   PubMed Web of Science ®Google Scholar
• Cmielova J, Havelek R, Jiroutova A, Kohlerova R, Seifrtova M, Muthna D, Vavrova J, Rezacova M. 2011. DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence. Physiological Research 60:667–677.
   PubMedGoogle Scholar
• Collins AR, Dusinská M, Gedik CM, Stĕtina R. 1996. Oxidative damage to DNA: Do we have a reliable biomarker?Environmental Health Perspectives 3:465–469.
   Google Scholar
• Deckbar D, Jeggo PA, Lobrich M. 2011. Understanding the limitations of radiation-induced cell cycle checkpoints. Critical reviews in biochemistry and molecular biology. 46:271–283.
   PubMed Web of Science ®Google Scholar
• Estrela C, Alencar AHG, Kitten GT, Vencio EF, Gava E. 2011. Mesenchymal stem cells in the dental tissues: Perspectives for tissue regeneration. Brazilian Dental Journal 22:91–98.
   PubMedGoogle Scholar
• Friesner JD, Liu B, Culligan K, Britt AB. 2005. Ionizing radiation- dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related. Molecular Biology of the Cell 16:2566–2576.
   PubMed Web of Science ®Google Scholar
• Gartel AL, Tyner AL. 2002. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Molecular Cancer Therapeutics 1:639–649.
   PubMed Web of Science ®Google Scholar
• Gay IC, Chen S, MacDougall M. 2007. Isolation and characterization of multipotent human periodontal ligament stem cells. Orthodontics and Craniofacial Research 10:149–160.
   PubMed Web of Science ®Google Scholar
• Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. 2004. Identification and characterization of a novel and specific inhibitor of the ataxia- telangiectasia mutated kinase ATM. Cancer Research 64:9152–9159.
   PubMed Web of Science ®Google Scholar
• Huang X, Darzynkiewicz Z. 2006. Cytometric assessment of histone H2AX phosphorylation: A reporter of DNA damage. Methods in Molecular Biology 314:73–80.
   PubMedGoogle Scholar
• Ju Z, Choudhury AR, Rudolph KL. 2006. A dual role of p21 in stem cell aging. Annals of the New York Academy Sciences 1100:333–344.
   Google Scholar
• Kao J, Milano MT, Javaheri A, Garofalo MC, Chmura SJ, Weichselbaum RR, Kron SJ. 2006. Gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy. Current Cancer Drug Targets 6:197–205.
   PubMed Web of Science ®Google Scholar
• Kassem M, Kristiansen M, Abdallah BM. 2004. Mesenchymal stem cells: Cell biology and potential use in therapy. Basic & Clinical Pharmacology & Toxicology 95:209–214.
   PubMed Web of Science ®Google Scholar
• Ljungman M. 2000. Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress. Neoplasia 2:208–225.
   PubMed Web of Science ®Google Scholar
• Lossaint G, Besnard E, Fisher D, Piette J, Duli V. 2011. Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. Oncogene 30:4261–4274.
   PubMed Web of Science ®Google Scholar
• Momčilovič O, Choi S, Varum S, Bakkenist C, Schatten G, Navara C. 2009. Ionizing radiation induces ataxia telangiectasia mutated- dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells. Stem Cells 27:1822–1835.
   PubMed Web of Science ®Google Scholar
• Mukherjee B, Kessinger C, Kobayashi J, Chen BP, Chen DJ, Chatterjee A, Burma S. 2006. DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair (Amst.) 10:575–590.
   Google Scholar
• Muthna D, Soukup T, Vavrova J, Mokry J, Cmielova J, Visek B, Jiroutova A, Havelek R, Suchanek J, Filip S, English D, Rezacova M. 2010. Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis. Stem Cells and Development 19:1855–1862.
   PubMed Web of Science ®Google Scholar
• Poehlmann A, Roessner A. 2010. Importance of DNA damage checkpoints in the pathogenesis of human cancers. Pathology, Research and Practice 206:591–601.
   PubMedGoogle Scholar
• Prendergast AM, Cruet-Hennequart S, Shaw G, Barry FP, Carty MP. 2011. Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or γ-irradiation. Cell Cycle 10:3768–3777.
   PubMed Web of Science ®Google Scholar
• Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. 2007. P53-deficient cells rely on ATM-and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 11:175–189.
   PubMed Web of Science ®Google Scholar
• Reinhardt HC, Yaffe MB. 2009. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2 and MK2. Current Opinion in Cell Biology 21:245–255.
   PubMed Web of Science ®Google Scholar
• Roninson IB. 2002. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Letters 179:1–14.
   PubMed Web of Science ®Google Scholar
• Sak A, Stuschke M. 2010. Use of γH2AX and other biomarkers of double-strand breaks during radiotherapy. Seminars in Radiation Oncology 20:233–231.
   Google Scholar
• Shay JW, Roninson IB. 2004. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23:2919–2933.
   PubMed Web of Science ®Google Scholar
• Shiloh Y. 2003. ATM and related protein kinases: Safeguarding genome integrity. Nature Reviews. Cancer 3:155–168.
   PubMed Web of Science ®Google Scholar
• Shrivastav M, Miller CA, De Haro LP, Durant ST, Chen BP, Chen DJ, Nickoloff JA. 2009. DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst.) 8:920–929.
   PubMed Web of Science ®Google Scholar
• Stiff T, O’Driscoll M, Rief N, Iwabuchi K, Löbrich M, Jeggo PA. 2004. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Research 64: 2390–2396.
   PubMed Web of Science ®Google Scholar
• Suchánek J, Soukup T, Ivancakova R, Karbanova J, Hubkova V, Pytlík R, Kučerová L. 2007. Human dental pulp stem cells – isolation and long term cultivation. Acta Medica (Hradec Kralove) 50:195–201.
   PubMedGoogle Scholar
• Suchánek J, Soukup T, Visek B, Ivancakova R, Kucerova L, Mokry J. 2009. Dental pulp stem cells and their characterization. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 153:31–36.
   PubMed Web of Science ®Google Scholar
• Taylor WR, Stark GR. 2001. Regulation of the G2/M transition by p53. Oncogene 20:1803–1815.
   PubMed Web of Science ®Google Scholar
• Uto K, Inoue D, Shimuta K, Nakajo N, Sagata N. 2004. Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism. The EMBO Journal 23:3386–3396.
   PubMed Web of Science ®Google Scholar
• Zhao T, Xu Y. 2010.p53 and stem cells: New developments and new concerns. Trends in Cell Biology 20:170–175.
   PubMed Web of Science ®Google Scholar