130
Views
3
CrossRef citations to date
0
Altmetric
RADIATION EFFECTS ON ORGANIC ANION TRANSPORTERS

Effect of X-ray irradiation on expression of organic anion transporting polypeptides

, , , , , & show all
Pages 832-840 | Received 18 Jun 2012, Accepted 05 Mar 2013, Published online: 16 Apr 2013

References

  • Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, Matsuno S. 2001. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 120:1689–1699.
  • Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. 2006. Interaction of methotrexate with organic- anion transporting polypeptide 1A2 and its genetic variants. Journal of Pharmacology and Experimental Therapeutics 318:521–529.
  • Bart J, Nagengast WB, Coppes RP, Wegman TD, van der Graaf WT, Groen HJ, Vaalburg W, de Vries EG, Hendrikse NH. 2007. Irradiation of rat brain reduces P-glycoprotein expression and function. British Journal of Cancer 97:322–326.
  • Bottke D, Koychev D, Busse A, Heufelder K, Wiegel T, Thiel E, Hinkelbein W, Keilholz U. 2008. Fractionated irradiation can induce functionally relevant multidrug resistance gene and protein expression in human tumor cell lines. Radiation Research 170:41–48.
  • Bronger H, König J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D, Nies AT. 2005. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Research 65:11419–11428.
  • Cui Y, König J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D. 2003. Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Laboratory Investigation 83:527–538.
  • Gillet JP, Calcagno AM, Varma S, Marino M, Green LJ, Vora MI, Patel C, Orina JN, Eliseeva TA, Singal V, Padmanabhan R, Davidson B, Ganapathi R, Sood AK, Rueda BR, Ambudkar SV, Gottesman MM. 2011. Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proceedings of the National Academy of Sciences of the USA 108:18708–18713.
  • Hagenbuch B, Meier PJ. 2003. The superfamily of organic anion transporting polypeptides. Biochimica et Biophysica Acta 1609:1–18.
  • Harmsen S, Koster AS, Beijnen JH, Schellens JH, Meijerman I. 2008. Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction. Drug Metabolism and Disposition 36:1166–1171.
  • Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell AL, Karlsson J. 2007. Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metabolism and Disposition 35:1333–1340.
  • Jigorel E, Le Vee M, Boursier-Neyret C, Bertrand M, Fardel O. 2005. Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes. Drug Metabolism and Disposition 33:1418–1422.
  • König J, Seithel A, Gradhand U, Fromm MF. 2006. Pharmacogenomics of human OATP transporters. Naunyn-Schmiedeberg's Archives of Pharmacology 372:432–443.
  • Kounnis V, Ioachim E, Svoboda M, Tzakos A, Sainis I, Thalhammer T, Steiner G, Briasoulis E. 2011. Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets. OncoTargets and Therapy 4:27–32.
  • Le Vee M, Jigorel E, Glaise D, Gripon P, Guguen-Guillouzo C, Fardel O. 2006. Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line. European Journal Pharmaceutical Sciences 28:109–117.
  • Mikkaichi T, Suzuki T, Tanemoto M, Ito S, Abe T. 2004. The organic anion transporter (OATP) family. Drug Metabolism and Pharmacokinetics 19:171–179.
  • Mo W, Zhang JT. 2012. Human ABCG2: Structure, function, and its role in multidrug resistance. International Journal of Biochemistry and Molecular Biology 3:1–27.
  • Nakanishi T, Tamai I. 2012. Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs. Drug Metabolism and Pharmacokinetics 27:106–121.
  • Nozawa T, Suzuki M, Takahashi K, Yabuuchi H, Maeda T, Tsuji A, Tamai I. 2004. Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells. Journal of Pharmacology and Experimental Therapeutics 311:1032–1037.
  • Poirier A, Funk C, Lavé T, Noé J. 2007. New strategies to address drug-drug interactions involving OATPs. Current Opinion in Drug Discovery and Development 10:74–83.
  • Pressler H, Sissung TM, Venzon D, Price DK, Figg WD. 2011. Expression of OATP family members in hormone-related cancers: Potential markers of progression. PLoS One 6:e20372.
  • Shitara Y, Sato H, Sugiyama Y. 2005. Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs. Annual Review of Pharmacology and Toxicology 45:689–723.
  • Smith NF, Acharya MR, Desai N, Figg WD, Sparreboom A. 2005. Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biology and Therapy 4:815–818.
  • Smith NF, Marsh S, Scott-Horton TJ, Hamada A, Mielke S, Mross K, Figg WD, Verweij J, McLeod HL, Sparreboom A. 2007. Variants in the OATP1B3 gene: Interethnic distribution and association with paclitaxel pharmacokinetics. Clinical Pharmacology and Therapeutics 81:76–82.
  • Tamai I. 2012. Oral drug delivery utilizing intestinal OATP transporter. Advanced Drug Delivery Reviews 64:508–514.
  • Van de Steeg E, van der Kruijssen CM, Wagenaar E, Burggraaff JE, Mesman E, Kenworthy KE, Schinkel AH. 2009. Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (OATP1B1). Drug Metabolism and Disposition 37:277–281.
  • Wlcek K, Svoboda M, Thalhammer T, Sellner F, Krupitza G, Jaeger W. 2008.. Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma. Cancer Biology and Therapy 7:1450–1455.
  • Yamaguchi H, Kobayashi M, Okada M, Takeuchi T, Unno M, Abe T, Goto J, Hishinuma T, Mano N. 2008. Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes. Cancer Letters 260:163–169.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.