Evaluation of the cytogenotoxic damage in immature and mature rats exposed to 900 MHz radiofrequency electromagnetic fields

References

• Albert RE, Magee PS. 2000. The tumorigenicity of mutagenic contact sensitizing chemicals. Risk Analysis 20:317–325.
   PubMed Web of Science ®Google Scholar
• Avci B, Akar A, Bilgici B, Tunçel OK. 2012. Oxidative stress induced by 1.8 Ghz radio frequency electromagnetic radiation and effects of the garlic extract in rats. International Journal of Radiation Biology 88:799–805.
   PubMed Web of Science ®Google Scholar
• Aydin B, Akar A. 2011. Effects of a 900-MHz electromagnetic field on oxidative stress parameters in rat lymphoid organs, polymorphonuclear leukocytes and plasma. Archives of Medical Research 42:261–267.
   PubMed Web of Science ®Google Scholar
• Baan R, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Islami F, Galichet L, Straif K; WHO International Agency for Research on Cancer Monograph Working Group. 2011. Carcinogenicity of radiofrequency electromagnetic fields. The Lancet Oncology 12:624–626.
   PubMed Web of Science ®Google Scholar
• Belyaev IY. 2010. Dependence of non-thermal biological effects of microwaves on physical and biological variables: Implications for reproducibility and safety standards. In: Giuliani L, Soffritti M, editors. Non-thermal effects and mechanisms of interaction between electromagnetic fields and living matter. European Journal of Oncology Library, An ICEMS Monograph, Vol. 5. Italy: Bologna. pp. 187–218.
   Google Scholar
• Belyaev IY, Markova E, Hillert L, Malmgren LOG, Persson BRR. 2009. Microwaves from UMTS/GSM mobile phones induce long-lasting inhibition of 53BP1/g-H2AX DNA repair foci in human lymphocytes. Bioelectromagnetics 30:129–141.
   PubMed Web of Science ®Google Scholar
• Belyaev IY, Hillert L, Protopopova M, Tamm C, Malmgren LO, Persson BR, Selinova G, Harms-Ringdahl M. 2005. 915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons. Bioelectromagnetics 26:173–184.
   PubMed Web of Science ®Google Scholar
• Bisht KS, Moros EG, Straube WL, Baty JD, Roti Roti JL. 2002. The effect of 835.62 MHz FDMA or 847.74 MHz CDMA modulated radiofrequency radiation on the induction of micronuclei in C3H 10T(1/2) cells. Radiation Research 157:506–515.
   PubMed Web of Science ®Google Scholar
• Dasdag S, Akdag Z, Ulukaya E, Uzunlar AK, Yegin D, Dasdag S, Akdag MZ, Ulukaya E, Uzunlar AK, Ocak AR. 2009. Effect of mobile phone exposure on apoptotic glial cells and status of oxidative stress in rat brain. Electromagnetic Biology and Medicine 28:342–354.
   PubMed Web of Science ®Google Scholar
• Demsia G, Vlastos D, Matthopoulos DP. 2004. Effect of 910-MHz electromagnetic field on rat bone marrow. Scientific World Journal 4:48–54.
   Google Scholar
• Esmekaya MA, Seyhan N, Omeroglu S. 2010. Pulse modulated 900 MHz radiation induces hypothyroidism and apoptosis in thyroid cells: A light, electron microscopy and immunohistochemical study. International Journal of Radiation Biology 86:1106–1116.
   PubMed Web of Science ®Google Scholar
• Federal Communications Commission. 2012. Radio frequency safety, Body tissue dielectric parameters tool. Available from: http://transition.fcc.gov/oet/rfsafety/dielectric.html.
   Google Scholar
• Frei P, Mohler E, Burgi A, Frohlich J, Neubauer G, Braun-Fahrlander C, Roosli M. 2010. Classification of personal exposure to radio frequency electromagnetic fields (RF-EMF) for epidemiological research: Evaluation of different exposure assessment methods. Environment International 36:714–720.
   PubMed Web of Science ®Google Scholar
• Ferreira AR, Bonatto F, de Bittencourt Pasquali MA, Polydoro M, Dal-Pizzol F, Fernandez C, de Salles AA, Moreira JC. 2006a. Oxidative stress effects on the central nervous system of rats after acute exposure to ultra high frequency electromagnetic fields. Bioelectromagnetics 27:487–493.
   PubMed Web of Science ®Google Scholar
• Ferreira AR, Knakievicz T, Pasquali MA, Gelain DP, Dal-Pizzol F, Fernandez CE, de Salles AA, Ferreira HB, Moreira JC. 2006b. Ultra high frequency-electromagnetic field irradiation during pregnancy leads to an increase in erythrocytes micronuclei incidence in rat offspring. Life Sciences 80:43–50.
   PubMed Web of Science ®Google Scholar
• Franzellitti S, Valbonesia P, Ciancaglinia N, Biondib C, Contina A, Bersanic F, Fabbria E. 2010. Transient DNA damage induced by high-frequency electromagnetic fields (GSM 1.8 GHz) in the human trophoblast HTR-8/SVneo cell line evaluated with the alkaline comet assay. Mutation Research 683:35–42.
   PubMed Web of Science ®Google Scholar
• Gadhia P, Shah T, Mistry A, Pithawala M, Tamakuwala D. 2003. A preliminary study to assess possible chromosomal damage among users of digital mobile phones. Electromagnetic Biology and Medicine 22:149–159.
   Web of Science ®Google Scholar
• Gajski G, Garaj-Vrhovac V. 2009. Radioprotective effects of honeybee venom (Apis mellifera) against 915-MHz microwave radiation- induced DNA damage in Wistar rat lymphocytes: In vitro study. International Journal of Toxicology 28:88–98.
   PubMed Web of Science ®Google Scholar
• Gandhi AG. 2005. Genetic damage in mobile phone users: Some preliminary findings. Indian Journal of Human Genetics 11:99–104.
   Google Scholar
• Gorlitz BD, Muller M, Ebert S, Hecker H, Kuster N, Dasenbrock C. 2005. Effects of 1-week and 6-week exposure to GSM/DCS radiofrequency radiation on micronucleus formation in B6C3F1 mice. Radiation Research 164:431–439.
   PubMed Web of Science ®Google Scholar
• Hamada S, Yamasaki K, Nakanishi S, Omori T, Serikawa T, Hayashi M. 2001. Evaluation of the general suitability of the rat for the micronucleus assay: The effect of cyclophosphamide in 14 strains. Mutation Research 495:127–134.
   PubMed Web of Science ®Google Scholar
• Hardell L, Sage C. 2008. Biological effects from electromagnetic field exposure and public exposure standards. Biomedicine & Pharmacotherapy 62:104–109.
   PubMed Web of Science ®Google Scholar
• Heddle JA. 1973. A rapid in vivo test for chromosomal damage. Mutation Research 18:187–190.
   PubMed Web of Science ®Google Scholar
• International Commission on Non-Ionizing Radiation Protection (ICNIRP), 1998. ICNIRP Guidelines; For Limiting Exposure to Time-Varying Electric, Magnetic and Electromagnetic Fields (Up to 300 GHz). Published in: Health Physics 74:494–522. Available from: http://www.icnirp.de/documents/emfgdl.pdf.
   PubMed Web of Science ®Google Scholar
• International Commission on Non-Ionizing Radiation Protection (ICNRP), 2009. Exposure to high frequency electromagnetic fields, biological effects and health consequences (100 kHz–300 GHz), ICNIRP 16/2009. Munich, Germany. Available from: http://www.icnirp.de/documents/RFReview.pdf.
   Google Scholar
• Joseph W, Frei P, Roosli M, Thuroczy G, Gajsek P, Trcek T, Bolte J, Vermeeren G, Mohler E, Juhasz P, Finta V, Martens L. 2010. Comparison of personal radio frequency electromagnetic field exposure in different urban areas across Europe. Environmental Research 110:658–663.
   PubMed Web of Science ®Google Scholar
• Juutilainen J, Heikkinen P, Soikkeli H, Maki-Paakkanen J. 2007. Micronucleus frequency in erythrocytes of mice after long-term exposure to radiofrequency radiation. International Journal of Radiation Biology 83:213–220.
   PubMed Web of Science ®Google Scholar
• Koyama S, Nakahara T, Wake K, Taki M, Isozumi Y, Miyakoshi J. 2003. Effects of high frequency electromagnetic fields on micronucleus formation in CHO-K1 cells. Mutation Research 541:81–89.
   PubMed Web of Science ®Google Scholar
• Koyu A, Cesur G, Ozguner F, Akdogan M, Mollaoglu H, Ozen S. 2005. Effects of 900 MHz electromagnetic field on TSH and thyroid hormones in rats. Toxicology Letters 157:257–262.
   PubMed Web of Science ®Google Scholar
• Mace ML Jr, Daskal Y, Wray W. 1978. Scanning-electron microscopy of chromosome aberrations. Mutation Research 52:199–206.
   PubMed Web of Science ®Google Scholar
• Maes A, Collier M, Slaets D, Verschaeve L. 1995. Cytogenetic effects of microwaves from mobile communication frequencies (954 MHz). Electro and Magnetobiology 14:91–98.
   Web of Science ®Google Scholar
• Maes A, Collier M, Van Gorp U, Vandoninck S, Verschaeve L. 1997. Cytogenetic effects of 935.2-MHz (GSM) microwaves alone and in combination with mitomycin C. Mutation Research 393:151–156.
   PubMed Web of Science ®Google Scholar
• Markova E, Hillert L, Malmgren LO, Persson BR, Belyaev IY. 2005. Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons. Environmental Health Perspectives 113:1172–1177.
   PubMed Web of Science ®Google Scholar
• Markova E, Malmgren LOG, Belyaev IY. 2010. Microwaves from mobile phones inhibit 53BP1 focus formation in human stem cells more strongly than in differentiated cells: Possible mechanistic link to cancer risk. Environmental Health Perspectives 118:394–399.
   PubMed Web of Science ®Google Scholar
• Mashevich M, Folkman D, Kesar A, Barbul A, Korenstein R, Jerby E, Avivi L. 2003. Exposure of human peripheral blood lymphocytes to electromagnetic fields associated with cellular phones leads to chromosomal instability. Bioelectromagnetics 24:82–90.
   PubMed Web of Science ®Google Scholar
• Mazor R, Korenstein-Ilan A, Barbul A, Eshet Y, Shahadi A, Jerby E, Korenstein R. 2008. Increased levels of numerical chromosome aberrations after in vitro exposure of human peripheral blood lymphocytes to radiofrequency electromagnetic fields for 72 hours. Radiation Research 169:28–37.
   PubMed Web of Science ®Google Scholar
• Otto M, von Muhlendahl KE. 2007. Electromagnetic fields (EMF): Do they play a role in children's environmental health (CEH)?. International Journal of Hygiene and Environmental Health 210:635–644.
   PubMed Web of Science ®Google Scholar
• Pavicic I, Trosic I. 2008. In vitro testing of cellular response to ultra high frequency electromagnetic field radiation. Toxicology in Vitro 22:1344–1348.
   PubMed Web of Science ®Google Scholar
• Peyman A, Rezazadeh A, Gabriel C. 2001. Changes in the dielectric properties of rat tissue as a function of age at microwave frequencies. Physics in Medicine and Biology 46:1617–1629.
   PubMed Web of Science ®Google Scholar
• Phillips J, Ivaschuk O, Ishida-Jones T, Jones R, Campbell-Beachler M, Haggren W. 1998. DNA damage in Molt-4 T lymphoblastoid cells exposed to cellular telephone radiofrequency fields in vitro. Bioelectrochemistry and Bioenergetics 45:103–110.
   Web of Science ®Google Scholar
• Phillips JL, Singh NP, Lai H. 2009. Electromagnetic fields and DNA damage. Pathophysiology 16:79–88.
   PubMedGoogle Scholar
• Preston RJ, Au W, Bender MA, Brewen JG, Carrano AV, Heddle JA, McFee AF, Wolff S, Wassom JS. 1981. Mammalian in vivo and in vitro cytogenetic assays: A report of the USEPA's gene-tox programme. Mutation Research 87:143–188.
   PubMed Web of Science ®Google Scholar
• Ruediger HW. 2009. Genotoxic effects of radiofrequency electromagnetic fields. Pathophysiology 16:89–102.
   PubMedGoogle Scholar
• Sarimov R, Malmgren LO, Markova E, Persson BR, Belyaev IY. 2004. Nonthermal GSM microwaves affect chromatin conformation in human lymphocytes similar to heat shock. IEEE Transactions on Plasma Science 32:1600–1608.
   Web of Science ®Google Scholar
• Savage JRK. 1976. Classification and relationships of induced chromosomal structural changes. Journal of Medical Genetics 13:103–122.
   PubMed Web of Science ®Google Scholar
• Schmid W. 1973. Chemical mutagen testing on in vivo somatic mammalian cells. Agents Actions 3:77–85.
   PubMedGoogle Scholar
• Schmid W. 1975. The micronucleus test. Mutation Research 31:9–15.
   PubMed Web of Science ®Google Scholar
• Şekeroğlu V, Akar A, Atlı Şekeroğlu Z. 2012. Cytotoxic and genotoxic effects of high-frequency electromagnetic fields (GSM 1800 MHz) on immature and mature rats. Ecotoxicology and Environmental Safety 80:140–144.
   PubMed Web of Science ®Google Scholar
• Simi S, Ballardin M, Casella M, De Marchi D, Hartwig V, Giovannetti G, Vanello N, Gabbriellini S, Landini L, Lombardi M. 2008. Is the genotoxic effect of magnetic resonance negligible?. Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan. Mutation Research 645:39–43.
   Google Scholar
• Speit G, Schütz P, Hoffmann H. 2007. Genotoxic effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in cultured mammalian cells are not independently reproducible. Mutation Research 626:42–47.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Nagae Y, Li J, Sabaka H, Mozawa K, Takahashi A, Shimizu H. 1989. The micronucleus test and erythropoiesis: Effects of erythropoietin and a mutagen on the ratio of polychromatic to normochromatic erythrocytes (P:N ratio). Mutagenesis 4:420–424.
   PubMed Web of Science ®Google Scholar
• Tice RR, Hook GG, Donner M, McRee DI, Guy AW. 2002. Genotoxicity of radiofrequency signals. I. Investigation of DNA damage and micronuclei induction in cultured human blood cells. Bioelectromagnetics 23:113–126.
   PubMed Web of Science ®Google Scholar
• Valberg PA, van Deventer TE, Repacholi MH. 2007. Workgroup report: Base stations and wireless networks – radiofrequency (RF) exposures and health consequences. Environmental Health Perspectives 115:416–24.
   PubMed Web of Science ®Google Scholar
• Verschaeve L. 2005. Genetic effects of radiofrequency radiation (RFR). Toxicology and Applied Pharmacology 207:336–341.
   PubMedGoogle Scholar
• Verschaeve L, Heikkinen P, Verheyen G, Van GU, Boonen F, Vander, PF, Maes A, Kumlin T, Maki-Paakkanen J, Puranen L, Juutilainen J. 2006. Investigation of co-genotoxic effects of radiofrequency electromagnetic fields in vivo. Radiation Research 165:598–607.
   PubMed Web of Science ®Google Scholar
• Verschaeve L, Juutilainen J, Lagroye I, Miyakoshi J, Saunders R, de Seze R, Tenforde T, van Rongen E, Veyret B, Xu Z. 2010. In vitro and in vivo genotoxicity of radiofrequency fields. Mutation Research 705:252–268.
   PubMed Web of Science ®Google Scholar
• Vijayalaxmi , Bisht KS, Pickard WF, Meltz MJ, Roti Roti JL, Moros EG. 2001a. Chromosome damage and micronucleus formation in human blood lymphocytes exposed in vitro to radiofrequency radiation at a cellular telephone frequency (847.74 MHz, CDMA). Radiation Research 156:430–432.
   PubMed Web of Science ®Google Scholar
• Vijayalaxmi , Leal BZ, Meltz ML, Pickard WF, Bisht KS, Roti Roti JL, Straube WL, Moros EG. 2001b. Cytogenetic studies in human blood lymphocytes exposed in vitro to radiofrequency radiation at a cellular telephone frequency (835.62 MHz, FDMA). Radiation Research 155:113–121.
   PubMed Web of Science ®Google Scholar
• Vijayalaxmi OG. 2004. Controversial cytogenetic observations in mammalian somatic cells exposed to radiofrequency radiation. Radiation Research 162:481–496.
   PubMed Web of Science ®Google Scholar
• Yadav O, Sharma MK. 2008. Increased frequency of micronucleated exfoliated cells among humans exposed in vivo to mobile telephone radiations. Mutation Research 650:175–180.
   PubMed Web of Science ®Google Scholar
• Ziemann C, Brockmeyer H, Reddy SB, Vijayalaxmi , Prihoda TJ, Kuster N, Tillmann T, Dasenbrock C. 2009. Absence of genotoxic potential of 902 MHz (GSM) and 1747 MHz (DCS) wireless communication signals: In vivo two-year bioassay in B6C3F1 mice. International Journal of Radiation Biology 85:454–464.
   PubMed Web of Science ®Google Scholar