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RADIORESISTANCE IN GLIOBLASTOMA CELLS

High resistance to X-rays and therapeutic carbon ions in glioblastoma cells bearing dysfunctional ATM associates with intrinsic chromosomal instability

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Pages 157-165 | Received 04 Feb 2014, Accepted 09 Jun 2014, Published online: 08 Sep 2014

References

  • Bartek J, Falck J, Lukas J. 2001. CHK2 kinase – a busy messenger. Nat Rev Mol Cell Biol 2:877–886.
  • Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW. 2003. Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114:359–370.
  • Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NC, Tokarz M, Adams BR, Wagner AF, Khalil A, Gilfor D, et al. 2013. ATM Kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. Clin Cancer Res 19:3189–3200.
  • Blakely EA, Kronenberg A. 1998. Heavy-ion radiobiology: New approaches to delineate mechanisms underlying enhanced biological effectiveness. Radiat Res 150(5 Suppl.):S126–145.
  • Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. 1998. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677–1679.
  • Costes SV, Boissiere A, Ravani S, Romano R, Parvin B, Barcellos-Hoff MH. 2006. Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts. Radiat Res 165:505–515.
  • Cremer M, Grasser F, Lanctot C, Muller S, Neusser M, Zinner R, Solovei I, Cremer T. 2008. Multicolor 3D fluorescence in situ hybridization for imaging interphase chromosomes. Methods Mol Biol 463:205–239.
  • Dokic I, Hartmann C, Herold-Mende C, Regnier-Vigouroux A. 2012. Glutathione peroxidase 1 activity dictates the sensitivity of glioblastoma cells to oxidative stress. Glia 60(11):1785–1800.
  • Fernandez LA, Squatrito M, Northcott P, Awan A, Holland EC, Taylor MD, Nahle Z, Kenney AM. 2012. Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation. Oncogene 31:1923–1937.
  • Franken NA, Rodermond HM, Stap J, Haveman J, van Bree C. 2006. Clonogenic assay of cells in vitro. Nat Protoc 1:2315–2319.
  • Gauter B, Zlobinskaya O, Weber KJ. 2002. Rejoining of radiation-induced DNA double-strand breaks: Pulsed-field electrophoresis analysis of fragment size distributions after incubation for repair. Radiat Res 157:721–733.
  • Geigl JB, Uhrig S, Speicher MR. 2006. Multiplex-fluorescence in situ hybridization for chromosome karyotyping. Nat Protoc 1:1172–1184.
  • Golding SE, Rosenberg E, Valerie N, Hussaini I, Frigerio M, Cockcroft XF, Chong WY, Hummersone M, Rigoreau L, Menear KA, et al. 2009. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther 8:2894–2902.
  • Karcher S, Steiner HH, Ahmadi R, Zoubaa S, Vasvari G, Bauer H, Unterberg A, Herold-Mende C. 2006. Different angiogenic phenotypes in primary and secondary glioblastomas. Int J Cancer 118:2182–2189.
  • Kinner A, Wu W, Staudt C, Iliakis G. 2008. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res 36:5678–5694.
  • Latz D, Dewey WC, Flentje M, Lohr F, Wenz F, Weber KJ. 1996. Migration patterns in pulsed-field electrophoresis of DNA restriction fragments from log-phase mammalian cells after irradiation and incubation for repair. Int J Radiat Biol 70:637–646.
  • Latz D, Fleckenstein K, Eble M, Blatter J, Wannenmacher M, Weber KJ. 1998. Radiosensitizing potential of gemcitabine (2′,2′-difluoro-2′-deoxycytidine) within the cell cycle in vitro. Int J Radiat Oncol Biol Phys 41:875–882.
  • Lavin MF, Birrell G, Chen P, Kozlov S, Scott S, Gueven N. 2005. ATM signaling and genomic stability in response to DNA damage. Mutat Res 569:123–132.
  • Li M, Fang X, Baker DJ, Guo L, Gao X, Wei Z, Han S, van Deursen JM, Zhang P. 2010. The ATM-p53 pathway suppresses aneuploidy- induced tumorigenesis. Proc Natl Acad Sci USA 107: 14188–14193.
  • Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH, Kastan MB. 2000. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404:613–617.
  • Mairani A, Bohlen TT, Dokic I, Cabal G, Brons S, Haberer T. 2013. Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation. Int J Radiat Biol 89:782–793.
  • Markova E, Schultz N, Belyaev IY. 2007. Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: Co-localization, relationship with DSB repair and clonogenic survival. Int J Radiat Biol 83: 319–329.
  • Matsuoka S, Huang M, Elledge SJ. 1998. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893–1897.
  • Mladenov E, Iliakis G. 2011. Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways. Mutat Res 711:61–72.
  • Prise KM, Ahnstrom G, Belli M, Carlsson J, Frankenberg D, Kiefer J, Löbrich M, Michael BD, Nygren J, Simone G, et al. 1998. A review of dsb induction data for varying quality radiations. Int J Radiat Biol 74:173–184.
  • Raso A, Vecchio D, Cappelli E, Ropolo M, Poggi A, Nozza P, Biassoni R, Mascelli S, Capra V, Kalfas F, et al. 2012. Characterization of glioma stem cells through multiple stem cell markers and their specific sensitization to double-strand break-inducing agents by pharmacological inhibition of ataxia telangiectasia mutated protein. Brain Pathol 22:677–688.
  • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273:5858–5868.
  • Rothkamm K, Löbrich M. 2003. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 100:5057–5062.
  • Squatrito M, Brennan CW, Helmy K, Huse JT, Petrini JH, Holland EC. 2010. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell 18:619–629.
  • Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, et al. 2004. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res 64:2998–3001.
  • Weber KJ, Flentje M. 1993. Lethality of heavy ion-induced DNA double-strand breaks in mammalian cells. Int J Radiat Biol 64:169–178.
  • Wyman C, Kanaar R. 2006. DNA double-strand break repair: All's well that ends well. Annu Rev Genet 40:363–383.

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