Ionizing radiation induces neuronal differentiation of Neuro-2a cells via PI3-kinase and p53-dependent pathways

References

• Abayomi OK. 1996. Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol 35:659–663.
   PubMed Web of Science ®Google Scholar
• Abeyama K, Kawano K, Nakajima T, Takasaki I, Kitajima I. 1995. Interleukin 6 mediated differentiation and rescue of cell redox in PC12 cells exposed to ionizing radiation. FEBS Lett 364:298–300.
   PubMed Web of Science ®Google Scholar
• Adan RA, van der Kraan M, Dpprnbos RP, Bär PR, Burbach JP, Gispen WH. 1996. Melanocortin receptor mediate α-MSH-induced stimulation of neurite outgrowth in Neuro 2A cells. Mol Brain Res 36:37–44.
   PubMedGoogle Scholar
• Arakawa H. 2005. p53, apoptosis and axon-guidance molecules. Cell Death Differ 12:1057–1065.
   PubMed Web of Science ®Google Scholar
• Ayumi O, Keiji S, Masatoshi S, Hiroki O, Shunichi Y. 2012. Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation. Mol Neurosci 22:290–293.
   Google Scholar
• Bernstein M, Gutin PH. 1981. Interstitial irradiation of brain tumors: A review. Neurosurgery 9:741–750.
   PubMed Web of Science ®Google Scholar
• Canon E, Cosgaya JM, Scsucova S, Aranda A. 2004. Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells. Mol Biol Cell 15:5583–5592.
   PubMed Web of Science ®Google Scholar
• Caporali S, Falcinelli S, Starace G, Russo MT, Bonmassar E, Jiricny J, et al. 2004. DNA damage induced by temozolomide signals to both ATM and ATR: Role of the mismatch repair system. Mol Pharmacol 66:478–491.
   PubMed Web of Science ®Google Scholar
• Chen H, Levison S, Toledo SD, Azzam E, Douayah N. 2012. Effects of ionizing radiation on Neural precursor cells. Neurology 78:020–023
   Google Scholar
• Chiang CS, McBride WH, Withers HR. 1993. Radiation-induced astrocytic and microglial responses in mouse brain. Radiother Oncol 29:60–68.
   PubMed Web of Science ®Google Scholar
• Crossen JR, Garwood D, Glatstein E, Neuwelt EA. 1994. Neuro behavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy. J Clin Oncol 12:627–642.
   PubMed Web of Science ®Google Scholar
• DiGiovanni S, Knights CD, Rao M, Yakovlev A, Beers J, Catania J, et al. 2006. The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. EMBO J 25:4084–4096.
   PubMed Web of Science ®Google Scholar
• DiAnna LH, Mike LS, Douglas AA, Diane MS. 2003. Rit promotes MEK-independent neurite branching in human neuroblastoma cells. J Cell Sci 116:1925–1935.
   PubMed Web of Science ®Google Scholar
• Eizenberg O, Faber-Elman A, Gottlieb E, Oren M, Rotter V, Schwartz M. 1996. p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells. Mol Cell Biol 16:5178–5185.
   PubMed Web of Science ®Google Scholar
• Evangelopoulos ME, Weis J, Kruttgen A. 2005. Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR. Oncogene 24:3309–3318.
   PubMed Web of Science ®Google Scholar
• Evangelopoulos ME, Weis J, Krüttgen A. 2009. Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR. J Neurosci Res 87:2138–2144.
   PubMed Web of Science ®Google Scholar
• Fenteany G, Standaert RF, Reichard GA, Corey EJ, Schreiber SL. 1994. A β-lactone related to lactacystin induce neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci USA 91:3358–3362.
   PubMed Web of Science ®Google Scholar
• Gracia LC, Lucrecia M, Susana M, Paloma P, Domingo B. 2002. Activation of the Phosphatidylinositol 3-Kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells. J Biol Chem 277:25297–25304.
   PubMed Web of Science ®Google Scholar
• Hughes AL, Gollapudi L, Sladek TL, Neet KE. 2000. Mediation of nerve growth factor-driven cell cycle arrest in PC12 cells by p53. Simultaneous differentiation and proliferation subsequent to p53 functional inactivation.J Biol Chem 275:37829–37837.
   PubMed Web of Science ®Google Scholar
• Inokoshi J, Katagiri M, Arima S, Tanaka H, Hayashi M, Kim YB, et al. 1999. Neuronal differentiation of Neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. Biochem Bioph Res Co 256:372–376.
   PubMed Web of Science ®Google Scholar
• Inouye M, Takahashi S, Kubota Y, Hayasaka S, Murata Y. 2000. Similarity between the effects of carbon-ion irradiation and X-irradiation on the development of rat brain. J Radiat Res 41:303–311.
   PubMed Web of Science ®Google Scholar
• Isono M, Otsu M, Konishi T, Matsubara K, Tanabe T, Nakayama T, et al. 2012. Proliferation and differentiation of neural stem cells irradiated with X-rays in logarithmic growth phase. Neurosci Res 73:263–268.
   PubMed Web of Science ®Google Scholar
• Jackson JG, Post SM, Lozano G. 2011. Regulation of tissue- and stimuls-specific cell fate decisions by p53 in vivo. J Pathol 223:127–136.
   PubMed Web of Science ®Google Scholar
• Jensh RP, Eisenman LM, Brent RL. 1995. Postnatal neurophysiologic effects of prenatal X-irradiation. Int J Radiat Biol 67:217–227.
   PubMed Web of Science ®Google Scholar
• Jingbo Q, Pritha P, Sora L, Lan Q, Erlena J, Joshua R. et al. 2012. PI3K/AKT and ERK regulate retinoic acid-induced neuroblastoma cellular differentiation. BBRC 424:421–426.
   PubMed Web of Science ®Google Scholar
• Kanzawa T, Iwado E, Aoki H, Iwamaru A, Hollingsworth EF, Sawaya R, et al. 2006. Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2- terminal kinase (JNK) pathway. Oncogene 25:3638–3648.
   PubMed Web of Science ®Google Scholar
• Lane MA, Bailey SJ. 2005. Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275–293.
   PubMed Web of Science ®Google Scholar
• Lee WH, Sonntag WE, Mitschelen M, Yan H, Lee YW. 2010. Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain. Int J Radiat Biol 86:132–144.
   PubMed Web of Science ®Google Scholar
• Lowe XR, Bhattacharya S, Marchetti F, Wyrobek AJ. 2009. Early brain response to low-dose radiation exposure involves molecular networks and pathways associated with cognitive functions, advanced aging and Alzheimer's disease. Radiat Res 171:53–65.
   PubMed Web of Science ®Google Scholar
• Min JY, Park MH, Park MK, Park KW, Lee NW, Kim T, et al. 2006. Staurosporin induces neurite outgrowth through ROS generation in HN33 hippocampal cell lines. J Neural Transm 113:1821–1826.
   PubMed Web of Science ®Google Scholar
• Monje ML, Mizumatsu S, Fike JR, Palmer TD. 2002. Irradiation induces neural precursor cell dysfunction. Nat Med 8:955–962.
   PubMed Web of Science ®Google Scholar
• Montano X. 1997. P53 associates with trk tyrosine kinase. Oncogene 15:245–256.
   PubMed Web of Science ®Google Scholar
• Moore DL, Goldberg JL. 2011. Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol 71:1186–1211.
   PubMed Web of Science ®Google Scholar
• Myers JS, Cortez D. 2006. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 281:9346–9350.
   PubMed Web of Science ®Google Scholar
• Nakagawara A. 2004. Neural crest development and neuroblastoma: The genetic and biological link. Prog Brain Res 146:233–242.
   PubMed Web of Science ®Google Scholar
• Oh CW, Bump EA, Kin JS, Janigro D, Mayberg MR. 2001. Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation. Radiat Res 156:232–240.
   PubMed Web of Science ®Google Scholar
• Oh SB, Park HR, Jang YJ, Choi SY, Son TG, Lee JW. 2013. Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation. Brit J Pharmacol 168:421–431.
   PubMed Web of Science ®Google Scholar
• Oren M, Rotter V. 1999. Introduction: p53 – the first twenty years. Cell Mol Life Sci 55:9–11.
   PubMed Web of Science ®Google Scholar
• Patapoutian A, Reichardt LF. 2001. Trk receptors: Mediators of neurotrophin action. Curr Opin Neurobiol 11:272–280.
   PubMed Web of Science ®Google Scholar
• Peissner W, Kocher M, Treuer H, Gillardon F. 1999. Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Res Mol Brain Res 71:61–68.
   PubMedGoogle Scholar
• Poluha W, Poluha DK, Chang B, Crosbie NE, Schonhoff CM, Kilpatrick DL, et al. 1996. The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. Mol Cell Biol 16:1335–1341.
   PubMed Web of Science ®Google Scholar
• Poluha W, Schonhoff CM, Harrington KS, Lachyankar MB, Crosbie NE, Bulseco DA, et al. 1997. Novel, nerve growth factor-activated pathway involving nitric oxide, p53, and p21WAF1 regulates neuronal differentiation of PC12 cells. J Biol Chem 272: 24002–24007.
   PubMed Web of Science ®Google Scholar
• Poongodi GL, Suresh N, Gopinath SC, Chang T, Inoue S, Inoue Y. 2002. Dynamic change of neural cell adhesion molecule polysialylation on human neuroblastoma (IMR-32) and rat pheochromocytoma (PC-12) cells during growth and differentiation. J Biol Chem 277:28200–28211.
   PubMed Web of Science ®Google Scholar
• Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, et al. 2004. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res 162:39–47.
   PubMed Web of Science ®Google Scholar
• Riley T, Sontag E, Chen P, Levine A. 2008. Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 9:402–412.
   PubMed Web of Science ®Google Scholar
• Sen A, Kallos MS, Behie LA. 2002. Passaging protocols for mammalian neural stem cells in suspension bioreactors. Biotechnol Prog 18:337–345.
   PubMed Web of Science ®Google Scholar
• Shuiliang Y, Liraz L, Ruth S, Noa N. 2012. Retinoic acid induces neurogenesis by activation both retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor β/δ (PPARβ/δ). J Biol Chem 287:42195–42205.
   PubMed Web of Science ®Google Scholar
• Surma-aho O, Niemelä M, Vilkki J, Kouri M, Brander A, Salonen O, et al. 2001. Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients. Neurology 56:1285–1290.
   PubMed Web of Science ®Google Scholar
• Tedeschi A, Di Giovanni S. 2009. The non-apoptotic role of p53 in neuronal biology: Enlightening the dark side of the moon. EMBO Rep 10:576–583.
   PubMed Web of Science ®Google Scholar
• Tedeschi A, Nguyen T, Puttagunta R, Gaub P, Di Giovanni S. 2009a. A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration. Cell Death Differ 16:543–554.
   Google Scholar
• Tedeschi A, Nguyen T, Steele SU, Feil S, Naumann U, Feil R, et al. 2009b. The tumor suppressor p53 transcriptionally regulates cGKI expression during neuronal maturation and is required for cGMP-dependent growth cone collapse. J Neurosci 29:15155–15160.
   PubMed Web of Science ®Google Scholar
• Tremblay RG, Sikorska M, Sandhu JL, Lanthier P, Ribecco-Lutkiewicz M, Bani-Yaghoub M. 2010. Differentiation of mouse Neuro 2A cells into dopamine neurons. J Neurosci Meth 186:60–67.
   PubMed Web of Science ®Google Scholar
• Xiaohui W, Zhuyao W, Yuzhen Y, Jingjin L, Xiaojin Z, Chuanfu L, et al. 2011. Essential role of ERK activation in neurite outgrowth induced by α-lipoic acid. Biochim Biophys Acta 1813:827–838.
   PubMed Web of Science ®Google Scholar
• Yona G, Shlomit E, Ronit PK. 2001. Neuregulin induces sustained reactive oxygen species generation to mediate neuronal differentiation. Cell Mol Neurobiol 21:753–769.
   PubMed Web of Science ®Google Scholar
• Yoshida K, Ozaki T, Furuya K, Nakanishi M, Kikuchi H, Yamamoto H, et al. 2008. ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin. Oncogene 27:1183–1188.
   PubMed Web of Science ®Google Scholar
• Yoshida T, Goto S, Kawakatsu M, Urata Y, Li TS. 2011. Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation. Free Radic Res 46:147–153.
   Web of Science ®Google Scholar
• Zhang J, Yan W, Chen X. 2006. p53 is required for nerve growth factor-mediated differentiation of PC12 cells via regulation of TrkA levels. Cell Death Differ 13:2118–2128.
   PubMedGoogle Scholar
• Zhang R, Kang KA, Kang SS, Park JW, Hyun JW. 2011. Morin (2′,3,4′,5, 7-pentahydroxyflavone) protected cells against gamma-radiation-induced oxidative stress. Basic Clin Pharmacol Toxicol 108:63–72.
   PubMed Web of Science ®Google Scholar