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Review

The quest to exploit the Auger effect in cancer radiotherapy – a reflective review

&
Pages 617-632 | Received 16 Sep 2015, Accepted 22 Dec 2015, Published online: 29 Feb 2016

References

  • Apelgot S, Coppey J, Gaudemer A, Grisvard J, Guille E, Sasaki I, Sissoeff I. 1989. Similar lethal effect in mammalian cells for two radioisotopes of copper with different decay schemes, 64Cu and 67Cu. Int J Radiat Biol. 55:365–384.
  • Apelgot S, Guille E. 1988. New concepts of DNA functioning as revealed by the lethal effect of 64Cu and 67Cu decays. In: Baverstock KFC, Charlton DE, editors. DNA damage by Auger emitters. Abingdon, UK: Taylor and Francis.
  • Auger P. 1923. Sur les rayons β secondaires produits dans un gaz par des rayons X. [On the secondary beta rays produced in a gas by x-rays]. Comptes Rendus Acad Sci. 177:131–144.
  • Auger P. 1975. The Auger effect. Surface Sci. 48:1–8.
  • Bakhshabadi M, Ghorbani M, Meigooni AS. 2013. Photon activation therapy: a Monte Carlo study on dose enhancement by various sources and activation media. Australas Phys Eng Sci Med. 36:301–311.
  • Balagurumoorthy P, Xu X, Wang K, Adelstein SJ, Kassis AI. 2012. Effect of distance between decaying 125I and DNA on Auger-electron induced double-strand break yield. Int J Radiat Biol. 88:998–1008.
  • Barth RF, Coderre JA, Vicente MG, Blue TE. 2005. Boron neutron capture therapy of cancer: current status and future prospects. Clin Cancer Res. 11:3987–4002.
  • Bentzen SM. 2000. Lise Meitner and Niels Bohr – a historical note. Acta Oncol. 39:1002–1003.
  • Biston MC, Joubert A, Adam JF, Elleaume H, Bohic S, Charvet AM, Esteve F, Foray N, Balosso J. 2004. Cure of Fisher rats bearing radioresistant F98 glioma treated with cis-platinum and irradiated with monochromatic synchrotron X-rays. Cancer Res. 64:2317–2323.
  • Bloomer WD, Adelstein SJ. 1977. 5-125I-iododeoxyuridine as prototype for radionuclide therapy with Auger emitters. Nature. 265:620–621.
  • Bloomer WD, McLaughlin WH, Weichselbaum RR, Hanson RN, Adelstein SJ, Seitz DE. 1981. The role of subcellular localization in assessing the cytotoxicity of iodine-125-labeled iododeoxyuridine, iodotamoxifen, and iodoantipyrine. J Radioanal Chem. 65:209–221.
  • Bloomer WD, McLaughlin WH, Weichselbaum RR, Tonnesen GL, Hellman S, Seitz DE, Hanson RN, Adelstein SJ, Rosner AL, Burstein NA, et al. 1980. Iodine-125-labelled Tamoxifen is differentially cytoxic to cells containing oestrogen receptors. Int J Radiat Biol. 38:197–202.
  • Bobyk L, Edouard M, Deman P, Rousseau J, Adam JF, Ravanat JL, Esteve F, Balosso J, Barth RF, Elleaume H. 2012. Intracerebral delivery of carboplatin in combination with either 6 MV photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma. J Exp Clin Cancer Res. 31:1089–1097.
  • Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Ohman L, Greene GL, Gustafsson JA, Carlquist M. 1997. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature. 389:753–758.
  • Burki HJ, Roots R, Feinendegen LE, Bond VP. 1973. Inactivation of mammalian cells after disintegration of 3H or 125I in cell DNA at −196 °C. Int J Radiat Biol. 24:363–375.
  • Carlson TA, White RM. 1966. Measurement of the relative abundances and recoil-energy spectra of fragment ions produced as the initial consequences of x-ray interaction with CH3I, HI, and DI. J Chem Phys. 44:4510–4520.
  • Ceberg C, Jonsson BA, Prezado Y, Pommer T, Nittby H, Englund E, Grafstrom G, Edvardsson A, Stenvall A, Stromblad S, et al. 2012. Photon activation therapy of RG2 glioma carrying Fischer rats using stable thallium and monochromatic synchrotron radiation. Phys Med Biol. 57:8377–8391.
  • Charlton DE, Booz J. 1981. A Monte Carlo treatment of the decay of 125I. Radiat Res. 87:10–23.
  • Charlton DE, Humm JL. 1988. A method of calculating initial DNA strand breakage following the decay of incorporated 125I. Int J Radiat Biol. 53:353–365.
  • Charlton DE, Nikjoo H, Humm JL. 1989. Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles. Int J Radiat Biol. 56:1–19.
  • Chen P, Cameron R, Wang J, Vallis KA, Reilly RM. 2003. Antitumor effects and normal tissue toxicity of 111In-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive human breast cancer xenografts. J Nucl Med. 44:1469–1478.
  • Corde S, Joubert A, Adam JF, Charvet AM, Le Bas JF, Esteve F, Elleaume H, Balosso J. 2004. Synchrotron radiation-based experimental determination of the optimal energy for cell radiotoxicity enhancement following photoelectric effect on stable iodinated compounds. Br J Cancer. 91:544–551.
  • Cornelissen B, Waller A, Able S, Vallis KA. 2013. Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and gammaH2AX. Mol Cancer Ther. 12:2472–2482.
  • Cornelissen B, Waller A, Target C, Kersemans V, Smart S, Vallis KA. 2012. 111In-BnDTPA-F3: an Auger electron-emitting radiotherapeutic agent that targets nucleolin. EJNMMI Res. 2:9.
  • Costantini DL, Chan C, Cai Z, Vallis KA, Reilly RM. 2007. (111)In-labeled trastuzumab (Herceptin) modified with nuclear localization sequences (NLS): an Auger electron-emitting radiotherapeutic agent for HER2/neu-amplified breast cancer. J Nucl Med. 48:1357–1368.
  • D’Andrea AD, Haseltine WA. 1978. Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin. Proc Natl Acad Sci USA. 75:3608–3612.
  • Dahmen V, Kriehuber R. 2012. Cytotoxic effects and specific gene expression alterations induced by I-125-labeled triplex-forming oligonucleotides. Int J Radiat Biol. 88:972–979.
  • Denoyer D, Lobachevsky P, Jackson P, Thompson M, Martin OA, Hicks RJ. 2015. Analysis of 177Lu-DOTA-octreotate therapy-induced DNA damage in peripheral blood lymphocytes of patients with neuroendocrine tumors. J Nucl Med. 56:505–511.
  • Duparc OH. 2009. Pierre Auger-Lise Meitner: comparative contributions to the Auger effect. Int J Materials Res. 100:1162–1166.
  • Edel S, Terrissol M, Peudon A, Kummerle E, Pomplun E. 2006. Computer simulation of strand break yields in plasmid pBR322: DNA damage following 125I decay. Radiat Prot Dosimetry. 122:136–140.
  • Epperly MW, Damodaran KM, McLaughlin WH, Pillai KM, Bloomer WD. 1991. Radiotoxicity of 17 alpha-[125I]iodovinyl-11 beta-methoxyestradiol in MCF-7 human breast cancer cells. J Steroid Biochem Mol Biol. 39:729–734.
  • Erikson RL, Szybalski W. 1963. Molecular radiobiology of human cell lines. V. Comparative radiosensitizing properties of 5-halodeoxycytidines and 5-halodeoxyuridines. Radiat Res. 20:252–262.
  • Ertl HH, Feinendegen LE. 1969. Microdosimetry of iodine-125 with reference to the Auger effect. In: Ebert H, editor. Proceedings of the 2nd Symposium on Microdosimetry. Euratom.
  • Fairchild RG, Bond VP. 1984. Photon activation therapy. Strahlentherapie. 160:758–763.
  • Fairchild RG, Brill AB, Ettinger KV. 1982. Radiation enhancement with iodinated deoxyuridine. Invest Radiol. 17:407–416.
  • Feinendegen LE. 1968. Problems associated with the use of labeled molecules in biology and medicine. General review. Panel on Biological Effects of Transmutation and Decay of Incorporated Radioisotopes, 1967. Vienna, Austria: IAEA.
  • Feinendegen LE. 1975. Effects of tritium on the human organism. J Belge Radiol. 58:147–155.
  • Feinendegen LE. 2012. The Auger effect in biology and medicine. Looking back. Int J Radiat Biol. 88:862–863.
  • Gaidamakova EK, Neumann RD, Panyutin IG. 2004. Antisense radiotherapy: targeting full-size mdrl mRNA with 125I-labelled oligonucleotides. Int J Radiat Biol. 80:889–893.
  • Goodman JH, Gahbauer RA, Kanellitsas C, Clendenon NR, Laster BH, Fairchild RG. 1990. Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and 145Sm as a brachytherapy source. Stereotact Funct Neurosurg. 54–55:531–534.
  • Goorley T, Terrissol M, Nikjoo H. 2008. Calculated strand breaks from (125)I in coiled DNA. Int J Radiat Biol. 84:1050–1056.
  • Harapanhalli RS, Howell RW, Rao DV. 1994. Bis-benzimidazole dyes, Hoechst 33258 and Hoechst 33342: radioiodination, facile purification and subcellular distribution. Nucl Med Biol. 21:641–647.
  • Haseltine WA, Maxam AM, Gilbert W. 1977. Rous sarcoma virus genome is terminally redundant: the 5′ sequence. Proc Natl Acad Sci USA. 74:989–993.
  • Helene C, Thuong NT, Harel-Bellan A. 1992. Control of gene expression by triple helix-forming oligonucleotides. The antigene strategy. Ann NY Acad Sci. 660:27–36.
  • Hofer KG, Hughes WL. 1971. Radiotoxicity of intranuclear tritium, 125 iodine and 131 iodine. Radiat Res. 47:94–101.
  • Hofer KG, Keough G, Smith JM. 1978. Biological toxicity of Auger emitters: molecular fragmentation versus electron irradiation. Curr Top Radiat Res Q. 12:335–354.
  • Hornick CA, Anthony CT, Hughey S, Gebhardt BM, Espenan GD, Woltering EA. 2000. Progressive nuclear translocation of somatostatin analogs. J Nucl Med. 41:1256–1263.
  • Howell RW. 2008. Auger processes in the 21st century. Int J Radiat Biol. 84:959–975.
  • Howell RW, Sgouros G, Committee SM. 2010. Kassis receives Loevinger-Berman award. J Nucl Med. 51:16N.
  • Humm JL, Charlton DE. 1988. Double-stranded breakage in DNA produced by the photoelectric interaction with incorporated ‘cold’ bromine. In: Baverstock KFC, Charlton DE, editors. DNA damage by Auger emitters. Abingdon, UK: Taylor and Francis.
  • Humm JL, Nikjoo H. 2013. David E. Charlton (1936–2013). Radiat Res. 180:553–555.
  • Janson ET, Westlin JE, Ohrvall U, Oberg K, Lukinius A. 2000. Nuclear localization of 111In after intravenous injection of [111In-DTPA-D-Phe1]-octreotide in patients with neuroendocrine tumors. J Nucl Med. 41:1514–1518.
  • Karagiannis TC, Lobachevsky PN, Leung BK, White JM, Martin RF. 2006. Receptor-mediated DNA-targeted photoimmunotherapy. Cancer Res. 66:10548–10552.
  • Karamychev VN, Panyutin IG, Kim MK, Le N, Paik CH, Carrasquillo JA, Reed MW, Neumann RD. 2000. DNA cleavage by 111In-labeled oligodeoxyribonucleotides. J Nucl Med. 41:1093–1101.
  • Karnas SJ, Moiseenko VV, Yu E, Truong P, Battista JJ. 2001. Monte Carlo simulations and measurement of DNA damage from x-ray-triggered auger cascades in iododeoxyuridine (IUdR). Radiat Environ Biophys. 40:199–206.
  • Kassis AI, Fayad F, Kinsey BM, Sastry KS, Adelstein SJ. 1989. Radiotoxicity of an 125I-labeled DNA intercalator in mammalian cells. Radiat Res. 118:283–294.
  • Kassis AI, Kirichian AM, Wang K, Semnani ES, Adelstein SJ. 2004. Therapeutic potential of 5-[125I]iodo-2′-deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitis. Int J Radiat Biol. 80:941–946.
  • Kobayashi K, Frohlich H, Usami N, Takakura K, Le Sech C. 2002. Enhancement of X-ray-induced breaks in DNA bound to molecules containing platinum: a possible application to hadrontherapy. Radiat Res. 157:32–37.
  • Kong G, Johnston V, Ramdave S, Lau E, Rischin D, Hicks RJ. 2009. High-administered activity In-111 octreotide therapy with concomitant radiosensitizing 5FU chemotherapy for treatment of neuroendocrine tumors: preliminary experience. Cancer Biother Radiopharm. 24:527–533.
  • Krisch RE, Sauri CJ. 1975. Further studies of DNA damage and lethality from the decay of iodine-125 in bacteriophages. Int J Radiat Biol Relat Stud Phys Chem Med. 27:553–560.
  • Kummerle EA, Pomplun E. 2005. A computer-generated supercoiled model of the pUC19 plasmid. Eur Biophys J. 34:13–18.
  • Kummerle EA, Pomplun E. 2012. Charge build-up during decay of DNA-incorporated (123/125)I: consequences for labeled molecular structures. Int J Radiat Biol. 88:922–927.
  • Laster BH, Dixon DW, Novick S, Feldman JP, Seror V, Goldbart ZI, Kalef-Ezra JA. 2009. Photon activation therapy and brachytherapy. Brachytherapy. 8:324–330.
  • Laster BH, Thomlinson WC, Fairchild RG. 1993. Photon activation of iododeoxyuridine: biological efficacy of Auger electrons. Radiat Res. 133:219–224.
  • Le Sech C, Takakura K, Saint-Marc C, Frohlich H, Charlier M, Usami N, Kobayashi K. 2000. Strand break induction by photoabsorption in DNA-bound molecules. Radiat Res. 153:454–458.
  • Limouris GS, Chatziioannou A, Kontogeorgakos D, Mourikis D, Lyra M, Dimitriou P, Stavraka A, Gouliamos A, Vlahos L. 2008. Selective hepatic arterial infusion of In-111-DTPA-Phe1-octreotide in neuroendocrine liver metastases. Eur J Nucl Med Mol Imaging. 35:1827–1837.
  • Liu X, Diao H, Nishi N. 2008. Applied chemistry of natural DNA. Chem Soc Rev. 37:2745–2757.
  • Lobachevsky PN, Martin RF. 2000. Iodine-125 decay in a synthetic oligodeoxynucleotide. II. The role of auger electron irradiation compared to charge neutralization in DNA breakage. Radiat Res. 153:271–278.
  • Lobachevsky PN, Martin RF. 2004. An improved approach to the analysis of plasmid DNA breakage by decay of DNA-associated auger emitters. Int J Radiat Biol. 80:861–866.
  • Lobachevsky PN, White J, Leung M, Skene C, White J, Martin RF. 2008. Plasmid breakage by (125)I-labelled DNA ligands: effect of DNA-iodine atom distance on breakage efficiency. Int J Radiat Biol. 84:991–1000.
  • Lydon MJ, Keeler KD, Thomas DB. 1980. Vital DNA staining and cell sorting by flow microfluorometry. J Cell Physiol. 102:175–181.
  • Maezawa H, Hieda K, Kobayasi K, Ito T. 1988. Effects of Auger cascades of bromine induced by K-shell photoinization of plasmid DNA, bacteriophages, E. coli and yeast cells. In: Baverstock KFC, Charlton DE, editors. DNA damage by Auger emitters. Abingdon, UK: Taylor and Francis.
  • Martin RF. 1977. Induction of double-stranded breaks in DNA by binding with an 125I-labelled acridine. Int J Radiat Biol. 32:491–497.
  • Martin RF, Bradley TR, Hodgson GS. 1979. Cytotoxicity of an 125I-labeled DNA-binding compound that induces double-stranded DNA breaks. Cancer Res. 39:3244–3247.
  • Martin RF, D'Cunha G, Pardee M, Allen BJ. 1988. Induction of double-strand breaks following neutron capture by DNA-bound 157Gd. Int J Radiat Biol. 54:205–208.
  • Martin RF, Haigh H, Monger C, Pardee M, Whittaker AD, Kelly DP, Allen BJ 1992. 157Gd-neutron capture – potential of 157Gd-labelled DNA ligands for gadolinium neutron capture therapy. In: Allen BJ, Moore DE, Harrington BV, editors. Progress in neutron capture therapy for cancer. New York: Springer.
  • Martin RF, Haseltine WA. 1981. Range of radiochemical damage to DNA with decay of iodine-125. Science. 213:896–898.
  • Martin RF, Holmes N. 1983. Use of an 125I-labelled DNA ligand to probe DNA structure. Nature. 302:452–454.
  • Martin RF, Pardee M. 1985. Preparation of carrier free [125I]iodoHoechst 33258. Int J Appl Radiat Isotopes. 36:745–747.
  • Maxam AM, Gilbert W. 1977. A new method for sequencing DNA. Proc Natl Acad Sci USA. 74:560–564.
  • McLaughlin WH, Milius RA, Pillai KM, Edasery JP, Blumenthal RD, Bloomer WD. 1989. Cytotoxicity of receptor-mediated 16 alpha-[125I]iodoestradiol in cultured MCF-7 human breast cancer cells. J Natl Cancer Inst. 81:437–440.
  • Meitner L. 1922. Über die Entstehung der β-Strahl-Spektren radioaktiver Substanzen. [About the generation of beta-ray spectra of radioactive substances]. Zeitschrift für Physik. 9:131–144.
  • Miller RW, DeGraff W, Kinsella TJ, Mitchell JB. 1987. Evaluation of incorporated iododeoxyuridine cellular radiosensitization by photon activation therapy. Int J Radiat Oncol Biol Phys. 13:1193–1197.
  • Moiseenko VV, Karnas SJ, Yu E, Battista JJ. 2002. Monte Carlo simulations of DNA damage from incorporated cold iodine following photoelectrically induced Auger electron cascades. Radiat Prot Dosimetry. 99:113–116.
  • Ndlebe T, Neumann RD, Panyutin IG. 2012. Study of charge transport mechanisms in (125)I-induced DNA damage at various temperatures. Int J Radiat Biol. 88:941–947.
  • Nikjoo H, Girard P. 2012. A model of the cell nucleus for DNA damage calculations. Int J Radiat Biol. 88:87–97.
  • Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG. 2009. Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs. Nucleic Acids Res. 37:7570–7580.
  • Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG. 2011. Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region. Nucleic Acids Res. 39:7114–7123.
  • Panyutin IG, Neumann RD. 1994. Sequence-specific DNA double-strand breaks induced by triplex forming 125I labeled oligonucleotides. Nucleic Acids Res. 22:4979–4982.
  • Panyutin IG, Neumann RD. 1996. Sequence-specific DNA breaks produced by triplex-directed decay of iodine-125. Acta Oncol. 35:817–823.
  • Panyutin IG, Neumann RD. 1998. Gene radiotherapy; gene targeted versus targeted by gene product. J Nucl Med. 39:928–929.
  • Panyutin IG, Neumann RD. 2005. The potential for gene-targeted radiation therapy of cancers. Trends Biotechnol. 23:492–496.
  • Panyutin IG, Sedelnikova OA, Karamychev VN, Neumann RD. 2003. Antigene radiotherapy: targeted radiodamage with 125i-labeled triplex-forming oligonucleotides. Ann NY Acad Sci. 1002:134–140.
  • Panyutin IG, Winters TA, Feinendegen LE, Neumann RD. 2000. Development of DNA-based radiopharmaceuticals carrying Auger-electron emitters for anti-gene radiotherapy. Q J Nucl Med. 44:256–267.
  • Panyutin IV, Sedelnikova OA, Bonner WM, Panyutin IG, Neumann RD. 2005. DNA damage produced by 125I-triplex-forming oligonucleotides as a measure of their successful delivery into cell nuclei. Ann NY Acad Sci. 1058:140–150.
  • Phillips TL. 1996. Comment on ‘survival improvement in anaplastic astrocytoma, combining external radiation with halogenated pyrimidines: final report of RTOG 86-12, Phase I-II Study’. Int J Radiat Oncol Biol Phys. 36:1281–1282.
  • Pomplun E. 1991. A new DNA target model for track structure calculations and its first application to I-125 Auger electrons. Int J Radiat Biol. 59:625–642.
  • Pomplun E, Booz J, Charlton DE. 1987. A Monte Carlo simulation of Auger cascades. Radiat Res. 111:533–552.
  • Praseuth D, Perrouault L, Le Doan T, Chassignol M, Thuong N, Helene C. 1988. Sequence-specific binding and photocrosslinking of alpha and beta oligodeoxynucleotides to the major groove of DNA via triple-helix formation. Proc Natl Acad Sci USA. 85:1349–1353.
  • Rahmanian S, Taleei R, Nikjoo H. 2014. Radiation induced base excision repair (BER): a mechanistic mathematical approach. DNA Repair (Amst). 22:89–103.
  • Reilly RM, Chen P, Wang J, Scollard D, Cameron R, Vallis KA. 2006. Preclinical pharmacokinetic, biodistribution, toxicology, and dosimetry studies of 111In-DTPA-human epidermal growth factor: an auger electron-emitting radiotherapeutic agent for epidermal growth factor receptor-positive breast cancer. J Nucl Med. 47:1023–1031.
  • Riley M, Maling B. 1966. Physical and chemical characterization of two- and three-stranded adenine-thymine and adenine-uracil homopolymer complexes. J Mol Biol. 20:359–389.
  • Rousseau J, Adam JF, Deman P, Wu TD, Guerquin-Kern JL, Gouget B, Barth RF, Esteve F, Elleaume H. 2009. Intracerebral delivery of 5-iodo-2′-deoxyuridine in combination with synchrotron stereotactic radiation for the therapy of the F98 glioma. J Synchrotron Radiat. 16:573–581.
  • Rousseau J, Boudou C, Barth RF, Balosso J, Esteve F, Elleaume H. 2007. Enhanced survival and cure of F98 glioma-bearing rats following intracerebral delivery of carboplatin in combination with photon irradiation. Clin Cancer Res. 13:5195–5201.
  • Sahu SK, Kortylewicz ZP, Baranowska-Kortylewicz J, Taube RA, Adelstein SJ, Kassis AI. 1997. Strand breaks after the decay of iodine-125 in proximity to plasmid pBR322 DNA. Radiat Res. 147:401–408.
  • Sanger F, Air GM, Barrell BG, Brown NL, Coulson AR, Fiddes CA, Hutchison CA, Slocombe PM, Smith M. 1977. Nucleotide sequence of bacteriophage phi X174 DNA. Nature. 265:687–695.
  • Sankaranarayanan K, Nikjoo H. 2015. Genome-based, mechanism-driven computational modeling of risks of ionizing radiation: the next frontier in genetic risk estimation? Mutat Res Rev Mutat Res. 764:1–15.
  • Sedelnikova OA, Karamychev VN, Panyutin IG, Neumann RD. 2002a. Sequence-specific gene cleavage in intact mammalian cells by 125I-labeled triplex-forming oligonucleotides conjugated with nuclear localization signal peptide. Antisense Nucleic Acid Drug Dev. 12:43–49.
  • Sedelnikova OA, Luu AN, Karamychev VN, Panyutin IG, Neumann RD. 2001. Development of DNA-based radiopharmaceuticals carrying Auger-electron emitters for antigene radiotherapy. Int J Radiat Oncol Biol Phys. 49:391–396.
  • Sedelnikova OA, Panyutin IG, Luu AN, Neumann RD. 1999. The stability of DNA triplexes inside cells as studied by iodine-125 radioprinting. Nucleic Acids Res. 27:3844–3850.
  • Sedelnikova OA, Panyutin IG, Luu AN, Reed MW, Licht T, Gottesman MM, Neumann RD. 2000. Targeting the human mdr1 gene by 125I-labeled triplex-forming oligonucleotides. Antisense Nucleic Acid Drug Dev. 10:443–452.
  • Sedelnikova OA, Panyutin IV, Neumann RD, Bonner WM, Panyutin IG. 2004. Assessment of DNA damage produced by 125I-triplex-forming oligonucleotides in cells. Int J Radiat Biol. 80:927–931.
  • Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. 2002b. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res. 158:486–492.
  • Song L, Falzone N, Vallis K. 2016. EGF-coated gold nanoparticles provide an efficient nano-scale delivery system for the molecular radiotherapy of EGFR-positive cancer. Int J Radiat Biol. this issue.
  • Sundell-Bergman S, Johanson KJ. 1982. Impaired repair capacity of DNA strand breaks induced by 125I-triiodothyronine in Chinese hamster cells. Biochem Biophys Res Commun. 106:546–552.
  • Sundell-Bergman S, Johanson KJ, Ludwikow G. 1988. Radiotoxic effects of 125I-labelled thyroid hormones with affinity to cellular chromatin. In: Baverstock KFC, Charlton DE, editors. DNA damage by Auger emitters. Abingdon, UK: Taylor and Francis.
  • Taleei R, Girard PM, Nikjoo H. 2015. DSB repair model for mammalian cells in early S and G1 phases of the cell cycle: application to damage induced by ionizing radiation of different quality. Mutat Res Genet Toxicol Environ Mutagen. 779:5–14.
  • Taleei R, Girard PM, Sankaranarayanan K, Nikjoo H. 2013. The non-homologous end-joining (NHEJ) mathematical model for the repair of double-strand breaks: II. Application to damage induced by ultrasoft X rays and low-energy electrons. Radiat Res. 179:540–548.
  • Terrissol M, Pomplun E. 1994. A nucleosome model for the simulation of DNA strand break experiments. Basic Life Sci. 63:243–250.
  • Tisljar-Lentulis G, Feinendegen LE, Bond VP. 1973. Biological radiation effects of inclusion of moderately heavy nuclei into the tissue and use of soft roentgen rays. Strahlentherapie. 145:656–662.
  • Urtasun RC, Kinsella TJ, Farnan N, DelRowe JD, Lester SG, Fulton DS. 1996. Survival improvement in anaplastic astrocytoma, combining external radiation with halogenated pyrimidines: final report of RTOG 86-12, Phase I–II study. Int J Radiat Oncol Biol Phys. 36:1163–1167.
  • Vallis KA, Reilly RM, Chen P, Oza A, Hendler A, Cameron R, Hershkop M, Iznaga-Escobar N, Ramos-Suzarte M, Keane P. 2002. A phase I study of 99mTc-hR3 (DiaCIM), a humanized immunoconjugate directed towards the epidermal growth factor receptor. Nucl Med Commun. 23:1155–1164.
  • Vallis KA, Reilly RM, Scollard D, Merante P, Brade A, Velauthapillai S, Caldwell C, Chan I, Freeman M, Lockwood G, et al. 2014. Phase I trial to evaluate the tumor and normal tissue uptake, radiation dosimetry and safety of (111)In-DTPA-human epidermal growth factor in patients with metastatic EGFR-positive breast cancer. Am J Nucl Med Mol Imaging. 4:181–192.
  • Van Essen M, Krenning EP, De Jong M, Valkema R, Kwekkeboom DJ. 2007. Peptide Receptor Radionuclide Therapy with radiolabelled somatostatin analogues in patients with somatostatin receptor positive tumours. Acta Oncol. 46:723–734.
  • Wexler S. 1967. Destruction of molecules by nuclear transformations. Science. 156:901–907.
  • Wexler S, Anderson GR. 1960. Dissociation of methyl bromide by nuclear isomeric transition of 4.4-hour Br80m. J Chem Phys. 33:850–857.
  • Whaley JM, Kassis AI, Kinsey BM, Adelstein SJ, Little JB. 1990. Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells. Int J Radiat Biol. 57:1087–1103.
  • Yasui L, Hughes A, DeSombre E. 2001. Relative biological effectiveness of accumulated 125IdU and 125I-estrogen decays in estrogen receptor-expressing MCF-7 human breast cancer cells. Radiat Res. 155:328–334.

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