Interactions between prebiotics, probiotics, polyunsaturated fatty acids and polyphenols: diet or supplementation for metabolic syndrome prevention?

References

• Akinkuolie AO, Ngwa JS, Meigs JB, Djoussé L. 2011. Omega-3 polyunsaturated fatty acid and insulin sensitivity: a meta-analysis of randomized controlled trials. Clin Nutr 30:702–707
   PubMed Web of Science ®Google Scholar
• Ali AA, Velasquez MT, Hansen CT, Mohamed AI, Bhathena SJ. 2004. Effects of soybean isoflavones, probiotics, and their interactions on lipid metabolism and endocrine system in an animal model of obesity and diabetes. J Nutr Biochem 15:583–590
   PubMed Web of Science ®Google Scholar
• Ali AA, Velasquez MT, Hansen CT, Mohamed AI, Bhathena SJ. 2005. Modulation of carbohydrate metabolism and peptide hormones by soybean isoflavones and probiotics in obesity and diabetes. J Nutr Biochem 16:693–699
   PubMed Web of Science ®Google Scholar
• Amaretti A, di Nunzio M, Pompei A, Raimondi S, Rossi M, Bordoni A. 2013. Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities. Appl Microbiol Biotechnol 97:809–817
   PubMed Web of Science ®Google Scholar
• Araya J, Rodrigo R, Orellana M, Rivera G. 2001. Red wine raises plasma HDL and preserves long-chain polyunsaturated fatty acids in rat kidney and erythrocytes. Br J Nutr 86:189–195
   PubMed Web of Science ®Google Scholar
• Axling U, Olsson C, Xu J, Fernandez C, Larsson S, Ström K, Ahrné S, et al. 2012. Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice. Nutr Metab (Lond) 9:105 . doi: 10.1186/1743-7075-9-105
   PubMed Web of Science ®Google Scholar
• Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. 2006. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 189:19–30
   PubMed Web of Science ®Google Scholar
• Bazzano LA, Thompson AM, Tees MT, Nguyen CH, Winham DM. 2011. Non-soy legume consumption lowers cholesterol levels: a meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis 21:94–103
   PubMed Web of Science ®Google Scholar
• Bernstein AM, Ding EL, Willett WC, Rimm EB. 2012. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. J Nutr 142:99–104
   PubMed Web of Science ®Google Scholar
• Bialonska D, Ramnani P, Kasimsetty SG, Muntha KR, Gibson GR, Ferreira D. 2010. The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. Int J Food Microbiol 140:175–182
   PubMed Web of Science ®Google Scholar
• Block G, Jensen CD, Norkus EP, Dalvi TB, Wong LG, McManus JF, Hudes ML. 2007. Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study. Nutr J 6:30 . doi: 10.1186/1475-2891-6-30
   PubMed Web of Science ®Google Scholar
• Bomba A, Nemcová R, Gancarcíková S, Herich R, Guba P, Mudronová D. 2002. Improvement of the probiotic effect of micro-organisms by their combination with maltodextrins, fructo-oligosaccharides and polyunsaturated fatty acids. Br J Nutr 88:S95–99
   PubMed Web of Science ®Google Scholar
• Burcelin R, Garidou L, Pomié C. 2012. Immuno-microbiota cross and talk: the new paradigm of metabolic diseases. Semin Immunol 24:67–74
   PubMed Web of Science ®Google Scholar
• Bustos I, García-Cayuela T, Hernández-Ledesma B, Peláez C, Requena T, Martínez-Cuesta MC. 2012. Effect of flavan-3-ols on the adhesion of potential probiotic lactobacilli to intestinal cells. J Agric Food Chem 60:9082–9088
   PubMed Web of Science ®Google Scholar
• Calder PC. 2012. The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability. Mol Nutr Food Res 56:1073–1080
   PubMed Web of Science ®Google Scholar
• Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, Esposito K, et al. 2011. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr 106 Suppl 3:S5–78
   PubMed Web of Science ®Google Scholar
• Camuesco D, Comalada M, Concha A, Nieto A, Sierra S, Xaus J, Zarzuelo A, Gálvez J. 2006. Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis. Clin Nutr 25:466–476
   PubMed Web of Science ®Google Scholar
• Cancelo Hidalgo MJ, Castelo-Branco C, Blumel JE, Lanchares Pérez JL, Alvarez De Los Heros JI; Isona Study Group. 2006. Effect of a compound containing isoflavones, primrose oil and vitamin E in two different doses on climacteric symptoms. J Obstet Gynaecol 26:344–347
   PubMedGoogle Scholar
• Castro IA, Barroso LP, Sinnecker P. 2005. Functional foods for coronary heart disease risk reduction: a meta-analysis using a multivariate approach. Am J Clin Nutr 82:32–40
   PubMed Web of Science ®Google Scholar
• Clavel T, Fallani M, Lepage P, Levenez F, Mathey J, Rochet V, Sérézat M, et al. 2005. Isoflavones and functional foods alter the dominant intestinal microbiota in postmenopausal women. J Nutr 135:2786–2792
   PubMed Web of Science ®Google Scholar
• Cueva C, Moreno-Arribas MV, Martín-Alvarez PJ, Bills G, Vicente MF, Basilio A, Rivas CL, et al. 2010. Antimicrobial activity of phenolic acids against commensal, probiotic and pathogenic bacteria. Res Microbiol 161:372–382
   PubMed Web of Science ®Google Scholar
• Das L, Bhaumik E, Raychaudhuri U, Chakraborty R. 2012. Role of nutraceuticals in human health. J Food Sci Technol 49:173–183
   PubMed Web of Science ®Google Scholar
• Davì G, Santilli F, Patrono C. 2010. Nutraceuticals in diabetes and metabolic syndrome. Cardiovasc Ther 28:216–226
   PubMed Web of Science ®Google Scholar
• de Lorgeril M, Salen P. 2012. New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids. BMC Med 10:50
   PubMed Web of Science ®Google Scholar
• Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A. 2013. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 18:1818–1892
   PubMed Web of Science ®Google Scholar
• Delzenne NM, Neyrinck AM, Bäckhed F, Cani PD. 2011. Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol 7:639–646
   PubMed Web of Science ®Google Scholar
• Dong JY, Wang P, He K, Qin LQ. 2011. Effect of soy isoflavones on circulating C-reactive protein in postmenopausal women: meta-analysis of randomized controlled trials. Menopause 18:1256–1262
   PubMed Web of Science ®Google Scholar
• Egert S, Rimbach G, Huebbe P. 2012. ApoE genotype: from geographic distribution to function and responsiveness to dietary factors. Proc Nutr Soc 71:410–424
   PubMed Web of Science ®Google Scholar
• Ferroni P, Vazzana N, Riondino S, Cuccurullo C, Guadagni F, Davì G. 2012. Platelet function in health and disease: from molecular mechanisms, redox considerations to novel therapeutic opportunities. Antioxid Redox Signal 17:1447–1485
   PubMed Web of Science ®Google Scholar
• Finnegan YE, Minihane AM, Leigh-Firbank EC, Kew S, Meijer GW, Muggli R, Calder PC, Williams CM. 2003. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 77:783–795
   PubMed Web of Science ®Google Scholar
• Fogliano V, Corollaro ML, Vitaglione P, Napolitano A, Ferracane R, Travaglia F, Arlorio M, et al. 2011. In vitro bioaccessibility and gut biotransformation of polyphenols present in the water-insoluble cocoa fraction. Mol Nutr Food Res 55:S44–55
   PubMed Web of Science ®Google Scholar
• Ghanim H, Sia CL, Upadhyay M, Korzeniewski K, Viswanathan P, Abuaysheh S, Mohanty P, Dandona P. 2010. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr 91:940–949
   PubMed Web of Science ®Google Scholar
• Gramaglia A, Loi GF, Mongioj V, Baronzio GF. 1999. Increased survival in brain metastatic patients treated with stereotactic radiotherapy, omega three fatty acids and bioflavonoids. Anticancer Res 19:5583–5586
   PubMed Web of Science ®Google Scholar
• Guo Z, Liu XM, Zhang QX, Shen Z, Tian FW, Zhang H, Sun ZH, et al. 2011. Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomised controlled trials. Nutr Metab Cardiovasc Dis 21:844–850
   PubMed Web of Science ®Google Scholar
• Hanwell HE, Kay CD, Lampe JW, Holub BJ, Duncan AM. 2009. Acute fish oil and soy isoflavone supplementation increase postprandial serum (n-3) polyunsaturated fatty acids and isoflavones but do not affect triacylglycerols or biomarkers of oxidative stress in overweight and obese hypertriglyceridemic men. J Nutr 139:1128–1134
   PubMed Web of Science ®Google Scholar
• Hartweg J, Farmer AJ, Holman RR, Neil HA. 2007. Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes. Diabetologia 50:250–258
   PubMed Web of Science ®Google Scholar
• Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, Shanman R, Johnsen B, Shekelle PG. 2012. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA 307:1959–1969
   PubMed Web of Science ®Google Scholar
• Hervert-Hernández D, Pintado C, Rotger R, Goñi I. 2009. Stimulatory role of grape pomace polyphenols on Lactobacillus acidophilus growth. Int J Food Microbiol 136:119–122
   PubMed Web of Science ®Google Scholar
• Hooper L, Kay C, Abdelhamid A, Kroon PA, Cohn JS, Rimm EB, Cassidy A. 2012b. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr 95:740–751
   PubMed Web of Science ®Google Scholar
• Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, Ryder JJ, et al. 2008. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 88:38–50
   PubMed Web of Science ®Google Scholar
• Hooper LV, Littman DR, Macpherson AJ. 2012a. Interactions between the microbiota and the immune system. Science 336:1268–1273
   PubMed Web of Science ®Google Scholar
• Horia E, Watkins BA. 2007. Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells. Carcinogenesis 28:809–815
   PubMed Web of Science ®Google Scholar
• Hume ME. 2011. Historic perspective: prebiotics, probiotics, and other alternatives to antibiotics. Poult Sci 90:2663–2669
   PubMed Web of Science ®Google Scholar
• Issazadeh-Navikas S, Teimer R, Bockermann R. 2012. Influence of dietary components on regulatory T cells. Mol Med 18:95–110
   PubMed Web of Science ®Google Scholar
• Jakesevic M, Aaby K, Borge GI, Jeppsson B, Ahrné S, Molin G. 2011. Antioxidative protection of dietary bilberry, chokeberry and Lactobacillus plantarum HEAL19 in mice subjected to intestinal oxidative stress by ischemia-reperfusion. BMC Complement Altern Med 11:8
   PubMed Web of Science ®Google Scholar
• Jia L, Liu X, Bai YY, Li SH, Sun K, He C, Hui R. 2010. Short-term effect of cocoa product consumption on lipid profile: a meta-analysis of randomized controlled trials. Am J Clin Nutr 92:218–225
   PubMed Web of Science ®Google Scholar
• Jiménez-Escrig A, Tenorio MD, Espinosa-Martos I, Rupérez P. 2008. Health-promoting effects of a dietary fiber concentrate from the soybean byproduct okara in rats. J Agric Food Chem 56:7495–7501
   PubMed Web of Science ®Google Scholar
• Jirillo E, Jirillo F, Magrone T. 2012. Healthy effects exerted by prebiotics, probiotics, and symbiotics with special reference to their impact on the immune system. Int J Vitam Nutr Res 82:200–208
   PubMed Web of Science ®Google Scholar
• Johnston BC, Ma SS, Goldenberg JZ, Thorlund K, Vandvik PO, Loeb M, Guyatt GH. 2012. Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann Intern Med 157:878–888
   PubMed Web of Science ®Google Scholar
• Juśkiewicz J, Zary-Sikorska E, Zduńczyk Z, Król B, Jurgoński A. 2011a. Physiological effects of chicory root preparations with various levels of fructan and polyphenolic fractions in diets for rats. Arch Anim Nutr 65:74–87
   PubMed Web of Science ®Google Scholar
• Juśkiewicz J, Zduńczyk Z, Zary-Sikorska E, Król B, Milala J, Jurgoński A. 2011b. Effect of the dietary polyphenolic fraction of chicory root, peel, seed and leaf extracts on caecal fermentation and blood parameters in rats fed diets containing prebiotic fructans. Br J Nutr 105:710–720
   PubMed Web of Science ®Google Scholar
• Kankaanpää PE, Yang B, Kallio HP, Isolauri E, Salminen SJ. 2002. Influence of probiotic supplemented infant formula on composition of plasma lipids in atopic infants. J Nutr Biochem 13:364–369
   PubMed Web of Science ®Google Scholar
• Kim A, Chiu A, Barone MK, Avino D, Wang F, Coleman CI, Phung OJ. 2011. Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. J Am Diet Assoc 111:1720–1729
   PubMed Web of Science ®Google Scholar
• Konrad M, Nieman DC, Henson DA, Kennerly KM, Jin F, Wallner-Liebmann SJ. 2011. The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. Int J Sport Nutr Exerc Metab 21:338–346
   PubMed Web of Science ®Google Scholar
• Koren E, Kohen R, Ovadia H, Ginsburg I. 2009. Bacteria coated by polyphenols acquire potent oxidant-scavenging capacities. Koren Exp Biol Med (Maywood) 234:940–951
   PubMed Web of Science ®Google Scholar
• Korzenik JR, Podolsky DK. 2006. Evolving knowledge and therapy of inflammatory bowel disease. Nat Rev Drug Discov 5:197–209
   PubMed Web of Science ®Google Scholar
• Landete JM. 2012. Updated knowledge about polyphenols: functions, bioavailability, metabolism, and health. Crit Rev Food Sci Nutr 52:936–948
   PubMed Web of Science ®Google Scholar
• Laparra JM, Sanz Y. 2010. Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacol Res 61:219–225
   PubMed Web of Science ®Google Scholar
• Larkin TA, Astheimer LB, Price WE. 2009. Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects. Eur J Clin Nutr 63:238–245
   PubMed Web of Science ®Google Scholar
• Larkin TA, Price WE, Astheimer LB. 2007. Increased probiotic yogurt or resistant starch intake does not affect isoflavone bioavailability in subjects consuming a high soy diet. Nutrition 23:709–718
   PubMed Web of Science ®Google Scholar
• Legette LL, Lee WH, Martin BR, Story JA, Arabshahi A, Barnes S, Weaver CM. 2011. Genistein, a phytoestrogen, improves total cholesterol, and synergy, a prebiotic, improves calcium utilization, but there were no synergistic effects. Menopause 18:923–931
   PubMed Web of Science ®Google Scholar
• Lettieri-Barbato D, Tomei F, Sancini A, Morabito G, Serafini M. 2013. Effect of plant foods and beverages on plasma non-enzymatic antioxidant capacity in human subjects: a meta-analysis. Br J Nutr 109:1544–1556
   PubMed Web of Science ®Google Scholar
• Li P, Hotamisligil GS. 2010. Metabolism: host and microbes in a pickle. Nature 464:1287–1288
   PubMed Web of Science ®Google Scholar
• Li S, Chen L, Yang T, Wu Q, Lv Z, Xie B, Sun Z. 2013. Increasing antioxidant activity of Procyanidin extracts from the pericarp of Litchi chinensis processing waste by two probiotic bacteria bioconversions. J Agric Food Chem 61:2506–2512
   PubMed Web of Science ®Google Scholar
• Liong MT, Shah NP. 2005a. Production of organic acids from fermentation of mannitol, fructooligosaccharide and inulin by a cholesterol removing Lactobacillus acidophilus strain. J Appl Microbiol 99:783–793
   PubMed Web of Science ®Google Scholar
• Liong MT, Shah NP. 2005b. Optimization of cholesterol removal, growth and fermentation patterns of Lactobacillus acidophilus ATCC 4962 in the presence of mannitol, fructo-oligosaccharide and inulin: a response surface methodology approach. J Appl Microbiol 98:1115–1126
   PubMed Web of Science ®Google Scholar
• Liu K, Xing A, Chen K, Wang B, Zhou R, Chen S, Xu H, Mi M. 2013b. Effect of fruit juice on cholesterol and blood pressure in adults: a meta-analysis of 19 randomized controlled trials. PLoS One 8:e61420
   PubMedGoogle Scholar
• Liu YJ, Zhan J, Liu XL, Wang Y, Ji J, He QQ. 2013a. Dietary flavonoids intake and risk of type 2 diabetes: a meta-analysis of prospective cohort studies. Clin Nutr Mar 26. pii: S0261-5614(13)00089-7
   Google Scholar
• MacDonald TT, Monteleone G. 2005. Immunity, inflammation, and allergy in the gut. Science 307:1920–1925
   PubMed Web of Science ®Google Scholar
• MacDonald TT, Monteleone I, Fantini MC, Monteleone G. 2011. Regulation of homeostasis and inflammation in the intestine. Gastroenterology 140:1768–1775
   PubMed Web of Science ®Google Scholar
• Magrone T, Jirillo E. 2013. The interplay between the gut immune system and microbiota in health and disease: nutraceutical intervention for restoring intestinal homeostasis. Curr Pharm Des 19:1329–1342
   PubMed Web of Science ®Google Scholar
• Magrone T, Perez de Heredia F, Jirillo E, Morabito G, Marcos A, Serafini M. 2013. Functional foods and nutraceuticals as therapeutic tools for the treatment of diet-related diseases. Can J Physiol Pharmacol 91:387–396
   PubMed Web of Science ®Google Scholar
• Marafini I, Zorzi F, Codazza S, Pallone F, Monteleone G. 2013. TGF-beta signaling manipulation as potential therapy for IBD. Curr Drug Targets 14:1400–1404
   Google Scholar
• Martinez-Micaelo N, González-Abuín N, Terra X, Richart C, Ardèvol A, Pinent M, Blay M. 2012. Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. Biochem J 441:653–663
   PubMed Web of Science ®Google Scholar
• Maskrey BH, Megson IL, Rossi AG, Whitfield PD. 2013. Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. Mol Nutr Food Res 57:1390–1400
   PubMed Web of Science ®Google Scholar
• Massaro M, Scoditti E, Carluccio MA, De Caterina R. 2010. Nutraceuticals and prevention of atherosclerosis: focus on omega-3 polyunsaturated fatty acids and Mediterranean diet polyphenols. Cardiovasc Ther 28:e13–e19
   PubMed Web of Science ®Google Scholar
• McAnulty SR, Nieman DC, McAnulty LS, Lynch WS, Jin F, Henson DA. 2011. Effect of mixed flavonoids, n-3 fatty acids, and vitamin C on oxidative stress and antioxidant capacity before and after intense cycling. Int J Sport Nutr Exerc Metab 21:328–337
   PubMed Web of Science ®Google Scholar
• McCullough ML, Peterson JJ, Patel R, Jacques PF, Shah R, Dwyer JT. 2012. Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 95:454–464
   PubMed Web of Science ®Google Scholar
• Monagas M, Khan N, Andrés-Lacueva C, Urpí-Sardá M, Vázquez-Agell M, Lamuela-Raventós RM, Estruch R. 2009. Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells. Br J Nutr 102:201–206
   PubMed Web of Science ®Google Scholar
• Monteleone G, Caruso R, Pallone F. 2014. Targets for new immunomodulation strategies in inflammatory bowel disease. Autoimmun Rev 13:11–14
   Google Scholar
• Monteleone G, Peluso I, Fina D, Caruso R, Andrei F, Tosti C, Pallone F. 2006. Bacteria and mucosal immunity. Dig Liver Dis 38:S256–60
   PubMedGoogle Scholar
• Monteleone I, Pallone F, Monteleone G. 2011. Th17-related cytokines: new players in the control of chronic intestinal inflammation. BMC Med 9:122
   PubMed Web of Science ®Google Scholar
• Moore LL. 2011. Functional foods and cardiovascular disease risk: building the evidence base. Curr Opin Endocrinol Diabetes Obes 18:332–335
   PubMed Web of Science ®Google Scholar
• Moschen AR, Wieser V, Tilg H. 2012. Dietary Factors: major regulators of the Gut's microbiota. Gut Liver 6:411–416
   PubMed Web of Science ®Google Scholar
• Neyrinck AM, Van Hée VF, Bindels LB, De Backer F, Cani PD, Delzenne NM. 2013. Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota. Br J Nutr 109:802–809
   PubMed Web of Science ®Google Scholar
• Nieman DC, Henson DA, Maxwell KR, Williams AS, McAnulty SR, Jin F, Shanely RA, Lines TC. 2009. Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. Med Sci Sports Exerc 41:1467–1475
   PubMed Web of Science ®Google Scholar
• Pallarès V, Calay D, Cedó L, Castell-Auví A, Raes M, Pinent M, Ardévol A, et al. 2012a. Additive, antagonistic, and synergistic effects of procyanidins and polyunsaturated fatty acids over inflammation in RAW 264.7 macrophages activated by lipopolysaccharide. Nutrition 28:447–457
   PubMed Web of Science ®Google Scholar
• Pallarès V, Calay D, Cedó L, Castell-Auví A, Raes M, Pinent M, Ardévol A, et al. 2012b. Enhanced anti-inflammatory effect of resveratrol and EPA in treated endotoxin-activated RAW 264.7 macrophages. Br J Nutr 108:1562–1573
   PubMed Web of Science ®Google Scholar
• Parkar SG, Stevenson DE, Skinner MA. 2008. The potential influence of fruit polyphenols on colonic microflora and human gut health. Int J Food Microbiol 124:295–298
   PubMed Web of Science ®Google Scholar
• Pauwels EK. 2011. The protective effect of the Mediterranean diet: focus on cancer and cardiovascular risk. Med Princ Pract 20:103–111
   PubMed Web of Science ®Google Scholar
• Peluso I, Fina D, Caruso R, Stolfi C, Caprioli F, Fantini MC, Caspani G, et al. 2007. Lactobacillus paracasei subsp. paracasei B21060 suppresses human T-cell proliferation. Infect Immun 75:1730–1737
   PubMed Web of Science ®Google Scholar
• Peluso I, Morabito G, Urban L, Ioannone F, Serafini M. 2012a. Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst. Endocr Metab Immune Disord Drug Targets 12:351–360
   PubMedGoogle Scholar
• Peluso I, Raguzzini A, Serafini M. 2013. Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: a systematic review and meta-analysis. Mol Nutr Food Res 57:784–801
   PubMed Web of Science ®Google Scholar
• Peluso I, Raguzzini A, Villano DV, Cesqui E, Toti E, Catasta G, Serafini M. 2012b. High fat meal increase of IL-17 is prevented by ingestion of fruit juice drink in healthy overweight subjects. Curr Pharm Des 18:85–90
   PubMed Web of Science ®Google Scholar
• Percival RS, Devine DA, Duggal MS, Chartron S, Marsh PD. 2006. The effect of cocoa polyphenols on the growth, metabolism, and biofilm formation by Streptococcus mutans and Streptococcus sanguinis. Eur J Oral Sci 114:343–348
   PubMed Web of Science ®Google Scholar
• Phillips T, Childs AC, Dreon DM, Phinney S, Leeuwenburgh C. 2003. A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Med Sci Sports Exerc 35:2032–2037
   PubMed Web of Science ®Google Scholar
• Polette A, Lemaitre D, Lagarde M, Véricel E. 1996. N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. Thromb Haemost 75:945–949
   PubMed Web of Science ®Google Scholar
• Potenza MV, Mechanick JI. 2009. The metabolic syndrome: definition, global impact, and pathophysiology. Nutr Clin Pract 24:560–577
   PubMed Web of Science ®Google Scholar
• Puupponen-Pimiä R, Nohynek L, Meier C, Kähkönen M, Heinonen M, Hopia A, Oksman-Caldentey KM. 2001. Antimicrobial properties of phenolic compounds from berries. J Appl Microbiol 90:494–507
   PubMed Web of Science ®Google Scholar
• Queipo-Ortuño MI, Boto-Ordóñez M, Murri M, Gomez-Zumaquero JM, Clemente-Postigo M, Estruch R, Cardona Diaz F, et al. 2012. Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers. Am J Clin Nutr 95:1323–1334
   PubMed Web of Science ®Google Scholar
• Radler U, Stangl H, Lechner S, Lienbacher G, Krepp R, Zeller E, Brachinger M, et al. 2011. A combination of (ω-3) polyunsaturated fatty acids, polyphenols and l-carnitine reduces the plasma lipid levels and increases the expression of genes involved in fatty acid oxidation in human peripheral blood mononuclear cells and HepG2 cells. Ann Nutr Metab 58:133–140
   PubMed Web of Science ®Google Scholar
• Raimondi S, Roncaglia L, De Lucia M, Amaretti A, Leonardi A, Pagnoni UM, Rossi M. 2009. Bioconversion of soy isoflavones daidzin and daidzein by Bifidobacterium strains. Appl Microbiol Biotechnol 81:943–950
   PubMed Web of Science ®Google Scholar
• Ridges L, Sunderland R, Moerman K, Meyer B, Astheimer L, Howe P. 2001. Cholesterol lowering benefits of soy and linseed enriched foods. Asia Pac J Clin Nutr 10:204–211
   PubMed Web of Science ®Google Scholar
• Ritchie ML, Romanuk TN. 2012. A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One 7:e34938
   PubMed Web of Science ®Google Scholar
• Roberfroid MB. 2005. Introducing inulin-type fructans. Br J Nutr 93:S13–S25
   PubMed Web of Science ®Google Scholar
• Roldán-Marín E, Krath BN, Poulsen M, Binderup ML, Nielsen TH, Hansen M, Barri T, et al. 2009. Effects of an onion by-product on bioactivity and safety markers in healthy rats. Br J Nutr 102:1574–1582
   PubMed Web of Science ®Google Scholar
• Shrime MG, Bauer SR, McDonald AC, Chowdhury NH, Coltart CE, Ding EL. 2011. Flavonoid-rich cocoa consumption affects multiple cardiovascular risk factors in a meta-analysis of short-term studies. J Nutr 141:1982–1988
   PubMed Web of Science ®Google Scholar
• Singh V, Singh K, Amdekar S, Singh DD, Tripathi P, Sharma GL, Yadav H. 2009. Innate and specific gut-associated immunity and microbial interference. Immunol Med Microbiol 55:6–12
   PubMedGoogle Scholar
• Steer TE, Johnson IT, Gee JM, Gibson GR. 2003. Metabolism of the soybean isoflavone glycoside genistin in vitro by human gut bacteria and the effect of prebiotics. Br J Nutr 90:635–642
   PubMed Web of Science ®Google Scholar
• Stradling C, Chen YF, Russell T, Connock M, Thomas GN, Taheri S. 2012. The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis. PLoS One 7:e38121
   PubMedGoogle Scholar
• Surette ME. 2013. Dietary omega-3 PUFA and health: stearidonic acid-containing seed oils as effective and sustainable alternatives to traditional marine oils. Mol Nutr Food Res 57:748–759
   PubMed Web of Science ®Google Scholar
• Suzuki H, Ishigaki A, Hara Y. 1998. Long-term effect of a trace amount of tea catechins with perilla oil on the plasma lipids in mice. Int J Vitam Nutr Res 68:272–274
   PubMed Web of Science ®Google Scholar
• Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. 2007. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr 85:1148–1156
   PubMed Web of Science ®Google Scholar
• Tamura A, Nishimukai M, Shigematsu N, Hara H. 2006. Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats. Br J Nutr 96:442–449
   PubMed Web of Science ®Google Scholar
• Tamura M, Hori S, Nakagawa H. 2011. Lactobacillus rhamnosus JCM 2771: impact on metabolism of isoflavonoids in the fecal flora from a male equol producer. Curr Microbiol 62:1632–1637
   PubMed Web of Science ®Google Scholar
• Tokede OA, Gaziano JM, Djoussé L. 2011. Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis. Eur J Clin Nutr 65:879–886
   PubMed Web of Science ®Google Scholar
• Toufektsian MC, Salen P, Laporte F, Tonelli C, de Lorgeril M. 2011. Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats. J Nutr 141:37–41
   PubMed Web of Science ®Google Scholar
• Tremaroli V, Bäckhed F. 2012. Functional interactions between the gut microbiota and host metabolism. Nature 489:242–249
   PubMed Web of Science ®Google Scholar
• Tsangalis D, Wilcox G, Shah NP, Stojanovska L. 2005. Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria. Br J Nutr 93:867–877
   PubMed Web of Science ®Google Scholar
• Tzounis X, Rodriguez-Mateos A, Vulevic J, Gibson GR, Kwik-Uribe C, Spencer JP. 2011. Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am J Clin Nutr 93:62–72
   PubMed Web of Science ®Google Scholar
• Uskova MA, Kravchenko LV, Avrenjeva LI, Tutelyan VA. 2010. Effect of Lactobacillus casei 114001 probiotic on bioactivity of rutin. Bull Exp Biol Med 149:578–582
   PubMed Web of Science ®Google Scholar
• Vafeiadou K, Hall WL, Williams CM. 2006. Does genotype and equol-production status affect response to isoflavones? Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal women. Proc Nutr Soc 65:106–115
   PubMed Web of Science ®Google Scholar
• Vigsnæs LK, Holck J, Meyer AS, Licht TR. 2011. In vitro fermentation of sugar beet arabino-oligosaccharides by fecal microbiota obtained from patients with ulcerative colitis to selectively stimulate the growth of Bifidobacterium spp. and Lactobacillus spp. Appl Environ Microbiol 77:8336–8344
   PubMed Web of Science ®Google Scholar
• Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, et al. 2010. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328:228–231
   PubMed Web of Science ®Google Scholar
• Vitali B, Minervini G, Rizzello CG, Spisni E, Maccaferri S, Brigidi P, Gobbetti M, Di Cagno R. 2012. Novel probiotic candidates for humans isolated from raw fruits and vegetables. Food Microbiol 31:116–125
   PubMed Web of Science ®Google Scholar
• Wedick NM, Pan A, Cassidy A, Rimm EB, Sampson L, Rosner B, Willett W, et al. 2012. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Clin Nutr 95:925–933
   PubMed Web of Science ®Google Scholar
• Wendland E, Farmer A, Glasziou P, Neil A. 2006. Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review. Heart 92:166–169
   PubMed Web of Science ®Google Scholar
• Wong JM, Kendall CW, de Souza R, Emam A, Marchie A, Vidgen E, Holmes C, Jenkins DJ. 2010. The effect on the blood lipid profile of soy foods combined with a prebiotic: a randomized controlled trial. Metabolism 59:1331–1340
   PubMed Web of Science ®Google Scholar
• Wong JM, Kendall CW, Marchie A, Liu Z, Vidgen E, Holmes C, Jackson CJ, et al. 2012. Equol status and blood lipid profile in hyperlipidemia after consumption of diets containing soy foods. Am J Clin Nutr 95:564–571
   PubMed Web of Science ®Google Scholar
• Wu JH, Micha R, Imamura F, Pan A, Biggs ML, Ajaz O, Djousse L, et al. 2012. Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis. Br J Nutr 107:S214–227
   PubMed Web of Science ®Google Scholar
• Yadav S, Gite S, Nilegaonkar S, Agte V. 2011. Effect of supplementation of micronutrients and phytochemicals to fructooligosaccharides on growth response of probiotics and E. coli. Biofactors 37:58–64
   PubMed Web of Science ®Google Scholar
• Zanoni S, Pompei A, Cordisco L, Amaretti A, Rossi M, Matteuzzi D. 2008. Growth kinetics on oligo- and polysaccharides and promising features of three antioxidative potential probiotic strains. J Appl Microbiol 105:1266–1276
   PubMed Web of Science ®Google Scholar
• Zhang YB, Chen WH, Guo JJ, Fu ZH, Yi C, Zhang M, Na XL. 2013. Soy isoflavone supplementation could reduce body weight and improve glucose metabolism in non-Asian postmenopausal women – a meta-analysis. Nutrition 29:8–14
   PubMed Web of Science ®Google Scholar
• Zheng JS, Huang T, Yang J, Fu YQ, Li D. 2012. Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis. PLoS One 7:e44525
   PubMed Web of Science ®Google Scholar
• Zheng XX, Xu YL, Li SH, Hui R, Wu YJ, Huang XH. 2013. Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials. Am J Clin Nutr 97:750–762
   PubMed Web of Science ®Google Scholar
• Zou J, Dong J, Yu X. 2009. Meta-analysis: Lactobacillus containing quadruple therapy versus standard triple first-line therapy for Helicobacter pylori eradication. Helicobacter 14:97–107
   PubMed Web of Science ®Google Scholar