Natural toxicants in the food supply: In vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin

References

• Ames B N, Magaw R, Gold L S. Ranking possible carcinogenic hazards. Science 1987; 236: 271–280
   PubMed Web of Science ®Google Scholar
• Ames B N, Profet M, Gold L S. Dietary pesticides (99.99% all natural). Proc. Natl Acad. Sci. USA 1990a; 87: 7777–7781
   PubMed Web of Science ®Google Scholar
• Ames B N, Profet M, Gold L S. Nature's chemicals and synthetic chemicals: comparative toxicology. Proc. Natl Acad. Sci. USA 1990b; 87: 7782–7786
   PubMed Web of Science ®Google Scholar
• Bjeldanes L F, Chang G W. Mutagenic activity of quercetin and related compounds. Science 1977; 197: 577–578
   PubMed Web of Science ®Google Scholar
• Bosca L, Rousseau G G, Hue L. Phorbol 12-myristate 13-acetate and insulin increase the concentration of fructose-2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts. Proc. Natl Acad. Sci. USA 1985; 82: 6440–6444
   PubMed Web of Science ®Google Scholar
• Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248–254
   PubMed Web of Science ®Google Scholar
• Brown J P. A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mutat. Res. 1980; 75: 243–277
   PubMed Web of Science ®Google Scholar
• Bruni P, Farnararo M, Vasta V, D'Alessandro A. Increase of the glycolytic rate in human resting fibroblasts following serum stimulation. FEBS Lett. 1983; 159: 39–42
   PubMed Web of Science ®Google Scholar
• Diamond I., Legg A., Schneider J A, Rozengurt E. Glycolysis in quiescent cultures of 3T3 cells Stimulation by serum, epidermal growth factor, and insulin in intact cells and persistence of the stimulation after cell homogenization. J. Biol. Chem. 1978; 253: 866–871
   PubMedGoogle Scholar
• Fujii H, Miwa S. Pyruvate kinase assay in serum and erythrocytes. Methods of Enzymatic Analysis, Volume III, Enzymes 1, 3rd edn, H U Bergmeyer. Academic Press, London 1983; 496–501
   Google Scholar
• Hohorst H J. D-Glucose-6-phosphate. Methods of Enzymatic Analysis, H U Bergmeyer. Academic Press, London 1963a; 134–138
   Google Scholar
• Hohorst H J. D-Fructose-6-phosphate. Methods of Enzymatic Analysis, H U Bergmeyer. Academic Press, London 1963b; 266–270
   Google Scholar
• Inoue M, Kishimoto A, Takai Y, Nishizuka Y. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. J. Biol. Chem. 1977; 252: 7610–7616
   PubMed Web of Science ®Google Scholar
• Ito N, Hagiwara A, Tamano S, Kagawa M, Shibata M-A, Kurata Y, Fukushima S. Lack of carcinogenicity of quercetin in F344 DuCrj rats Jpn. J. Cancer Res. 1989; 80: 317–325
   Google Scholar
• Kuo J F, Andersson R GG, Wise B C, Mackerlova L, Salomonsson I, Brackett N L, Katoh N, Shoji M, Wrenn R W. Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin and trifluoperazine. Proc. Natl Acad. Sci. USA 1980; 77: 7039–7043
   PubMedGoogle Scholar
• Lee K. Food neophobia: major causes and treatments. Food Technol 1989; 43(12)62–73
   Google Scholar
• Loiseau A M, Rousseau G G, Hue L. Fructose-2,6-bisphosphate and the control of glycolysis by glucocorticoids and by other agents in rat hepatoma cells. Cancer Res. 1985; 45: 4263–4269
   PubMedGoogle Scholar
• Maruta A, Enaka K, Umeda M. Mutagenicity of quercetin and kaempferol on cultured mammalian cells. GANN 1979; 70: 273–276
   PubMedGoogle Scholar
• Morino K, Matsukura N, Kawachi T, Ohgaki H, Sugimura T, Hirono I. Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration. Carcinogenesis 1982; 3: 93–97
   PubMed Web of Science ®Google Scholar
• National Research Council. Diet and Health. Implications for reducing chronic disease risk. National Academy Press, Washington, DC 1989
   Google Scholar
• Nishizuka Y. The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 1984; 308: 693–698
   PubMed Web of Science ®Google Scholar
• Pamukcu A M, Yalciner S, Hatcher J F, Bryan G T. Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). Cancer Res. 1980; 40: 3468–3472
   PubMed Web of Science ®Google Scholar
• Rider M, Hue L. Regulation of fructose-2,6-bisphosphate concentration in white adipose tissue. Biochem. J. 1985; 225: 421–428
   PubMedGoogle Scholar
• Herbivores: Their interaction with secondary plant metabolites, G A Rosenthal, D H Janzen. Academic Press, New York 1979
   Google Scholar
• Rozengurt E, Rodriguez-Pena A, Coombs M, Sinnett-Smith J. Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase. Proc. Natl. Acad. Sci. USA 1984; 81: 5748–5752
   PubMed Web of Science ®Google Scholar
• Saito D, Shirai A, Matsushima T, Hirono I. Test of carcinogenicity of quercetin, a widely distributed mutagen in food Teratogenesis Carcinog. Mutagen. 1980; 1: 213–221
   Google Scholar
• Schamhart D HJ, van de Poll K W, van Wijk R. Comparative studies of glucose metabolism in HTC, RLC, MH1C1 and Reuber H35 rat hepatoma cells. Cancer Res. 1979; 39: 1051–1055
   PubMed Web of Science ®Google Scholar
• Van Schaftingen E, Hue L, Hers H-G. Fructose-2,6-bisphosphate, the probable structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase. Biochem. J. 1980; 192: 897–901
   PubMed Web of Science ®Google Scholar
• Van Schaftingen E, Lederer B, Bartrons R, Hers H-G. A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers Application to a microassay of fructose-2,6-bisphosphate. Eur. J. Biochem. 1982; 129: 191–195
   PubMedGoogle Scholar
• Vassault A. Lactate dehydrogenase u.v. method with pyruvatc and NADH. Methods of Enzymatic Analysis, H U Bergmeyer. Academic Press, London 1983; 118–126
   Google Scholar
• Watson W AF. The mutagenic activity of quercetin and kaempferol in Drosophila melanogaster. Mutat. Res. 1982; 103: 145–147
   PubMed Web of Science ®Google Scholar