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Original Article

Lipid peroxidation: A review of causes, consequences, measurement and dietary influences

Pages 233-261 | Published online: 06 Jul 2009

References

  • Ames B N. Measuring oxidative damage in humans: relation to cancer and aging. IARC Sci. Publ. 1988; 89: 407–416
  • Avogaro P, Bon G B, Cazzolato G. Presence of a modified low density lipoprotein in humans. Arteriosclerosis 1988; 8: 79–87
  • Barnett Y A. Nutrition and the ageing process. Br. J. Biomed. Sci. 1994; 51: 278–287
  • Baumstark M W, Aristegui R, Zoller T, Frey I, Berg A, Keul J. Probucol, incorporated into LDL particles in vivo, inhibits generation of lipid peroxidases more effectively than endogenous antioxidants alone. Clin. Biochem. 1992; 25: 395–397
  • Beckman J S, Chen J, Ischiropoulos H, Crow J P. Oxidative chemistry of peroxynitrite. Methods in Enzymology, Vol. 233, part C: Oxygen Radicals in Biological Systems, L Packer. Academic Press., San Diego 1994; 229–240
  • Beetons J R, Coene M-C, Verheyen A, Zonnekeyn L, Herman A G. Vitamin C increases prostacyclin production and decreases the vascular lesions in experimental atherosclerosis in rabbits. Prostaglandins 1986; 32: 335–352
  • Behrens W A, Thompson J N, Madere R. Distribution of alpha tocopherol in human plasma lipoproteins. Am. J. Clin. Nutr. 1982; 35: 691–696
  • Benzie I FF. An automated, specific, spectrophotometric method for measuring ascorbic acid in plasma (EFTSA). Clin. Biochem. 1996, in press
  • Benzie I FF, Strain J J. The effect of ascorbic acid on the measurement of total cholesterol and triglycerides: possible artefactual lowering in individuals with high plasma concentration of ascorbic acid. Clin. Chim. Acta 1995; 239: 185–190
  • Berry E M. The effects of nutrients on lipoprotein susceptibility to oxidation. Curr. Opin. Lipidol. 1992; 3: 5–11
  • Bjorkhem I, Henrikksson-Freyschuss A, Breuer O, Diczfalusy U, Berglund L, Jenriksson P. The antioxidant butylated hydroxytoluene protects against atherosclerosis. Artertioscler. Thromb. 1991; 11: 15–22
  • Blann A, Midgely H, Burrows G, Maxwell S, Utting S, Davies M, Waite M, McCollum C. Free radicals, antioxidants and endothelial cell damage after percutaneous transluminal coronary angioplasty. Coron. Art. Dis. 1993; 4: 905–910
  • Block G. Vitamin C and cancer prevention: the epidemiologic evidence. Am. J. Clin. Nutr. 1991; 53: 270S–282S
  • Bolli R. Mechanism of myocardial ‘stunning’. Circulation 1990; 82: 723–738
  • Borg D C. Oxygen free radicals and tissue injury. Oxygen Free Radicals in Tissue Damage, M Tarr, F. Samson. Birkhauser., Boston 1993; 12–55
  • Bowry V W, Stanley K K, Stocker R. High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors. Proc. Natl Acad. Sci. USA 1992; 89: 10316–10320
  • Brown K M, Morrice P C, Duthie G G. Vitamin E supplementation suppresses indexes of lipid peroxidation and platelet counts in blood of smokers and nonsmokers but plasma lipoprotein concentrations remain unchanged. Am. J. Clin. Nutr. 1994; 60: 383–387
  • Brown M S, Goldstein J L. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232: 34–47
  • Bulkley G B. Reactive oxygen metabolites and reperfusion injury: aberrant triggering of reticuloendothelial function. Lancet 1994; 344: 934–936
  • Bunker V W. Free radicals, antioxidants and ageing. Med. Lab. Sci. 1992; 49: 299–312
  • Burton G W, Wronska U, Stone L, Foster D O, Ingold K U. Biokinetics of dietary RRR-alpha-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not ‘spare’ vitamin E. in vivo. Lipids 1990; 25: 199–210
  • Carcelain G, David F, Lepage S, Bonnefont-Rousselot D, Delattre J, Legrand A, Peynet J, Troupel S. Simple method for quantifying alpha tocopherol in low density- and very low density-lipoproteins and in high density lipoproteins. Clin. Chem. 1992; 38: 1792–1795
  • Oxy-Radicals in Molecular Biology and Pathology, P Cerutti, I Fridovich, J M McCord. Alan R. Liss., New York 1988
  • Cerutti P A. Oxy-radicals and cancer. Lancet 1994; 344: 862–863
  • Chait A, Heinecke J W. Lipoprotein modification: cellular mechanisms. Curr. Opin. Lipidol. 1994; 5: 365–370
  • Chatterjee S. Role of oxidised human plasma low density lipoproteins in atherosclerosis: effects on smooth muscle cell proliferation. Molec. Cell. Biochem. 1992; 111: 143–147
  • Cheeseman K H, Slater T F. Free Radicals in Medicine. Br. Med. Bull. 1993; 49: 479–724
  • Chirico S, Smith C, Marchant C, Mitchinson M J, Halliwell B. Lipid peroxidation in hyperlipidaemic patients; a study of plasma using an HPLC-based thiobarbituric acid test. Free Rad. Res. Commun. 1993; 19: 51–57
  • Chow C K, Changchit C, Bridges R B, Rehn S R, Humble J, Turbek J. Lower levels of vitamin C and carotenes in plasma of cigarette smokers. Am. J. Pub. Hlth 1989; 79: 158–162
  • Clausen J, Nielsen S A, Kristensen M. Biochemical and clinical effects of an antioxidant supplementation of geriatric patients. Biol. Trace Elem. Res. 1989; 20: 135–151
  • Cloarec M J, Perdriset G M, Lamberdiere F A, Colas-Belcour J F, Sauzieres J P, Neufeld H N, Goldbourt U. Alpha tocopherol: effect on plasma lipoproteins in hypercholesterolaemic patients. Isr. J. Med. Sci. 1987; 23: 869–872
  • Comstock G W, Helzlsouer K J, Bush T L. Prediagnostic serum levels of carotenoids and vitamin E as related to subsequent cancer in Washington Country, Maryland. Am. J. Clin. Nutr. 1991; 53: 260S–264S
  • Conti M, Morand P C, Levillain P, Lemonnier A. Improved fluorimetric determination of malonaldehyde. Clin. Chem. 1991; 37: 1273–1275
  • Coughlan J G, Flitter W D, Holley A E, Norell M, Mitchell A G, Ilsley C D, Slater T F. Detection of free radicals and cholesterol hydroperoxides in blood taken from the coronary sinus of man during percutaneous transluminal coronary angioplasty. Free Rad. Res. Commun. 1991; 14: 409–417
  • Croft K D, Dimmitt S B, Moulton C, Beilin L J. Low density lipoprotein composition and oxidisability in coronary disease - apparent favourable effect of beta blockers. Atherosclerosis 1992; 97: 123–130
  • Croft K D, Williams P, Dimmitt S, Abu-Amsha R, Beilin L J. Oxidation of low density lipoproteins: effect of antioxidant content, fatty acid composition and intrinsic phospholipase activity on susceptibility to metal ion-induced oxidation. Biochim. Biophys. Acta 1995; 1254: 250–256
  • Cutler R C. Antioxidants and aging. Am. J. Cl. Nutr. 1991; 53: 373S–379S
  • Davies M B. Vitamin C: Its Chemistry and Biochemistry. Royal Society of Chemistry., Cambridge 1991
  • Department of Health. Dietary reference values for food energy and nutrients for the United Kingdom. Dep. Hlth Soc. Subj. No. 41. DHSS., London 1991
  • Di Masco P, Murphy M E, Sies H. Antioxidant defense systems: the role of carotenoids, tocopherols and thiols. Am. J. Clin. Nutr. 1991; 53: 194S–200S
  • Dieber-Rotheneder M, Puhl H, Waeg G, Striegl G, Esterbauer H. Effect of oral supplementation with d-alpha-tocopherol on the vitamin E content of human low density lipoprotein and resistance to oxidation. J. Lipid Res. 1991; 32: 1325–1332
  • Diplock A T. Fat Soluble Vitamins: Their Biochemistry and Applications. Heinemann., London 1985
  • Duthie G G. Lipid peroxidation. Eur. J. Clin. Nutr. 1993; 47: 759–764
  • Elinder L S, Walldius G. Antioxidants and atherosclerosis progression: unresolved questions. Curr. Opin. Lipidol. 1994; 5: 265–268
  • Emerit I, Chance B. Free Radicals and Aging. Birkhauser., Boston 1992
  • Emerit I. Reactive oxygen species, chromosome mutation and cancer: possible role of clastogenic factors in carcinogenesis. Free Rad. Biol. Med. 1994; 16: 99–109
  • Espinosa-Mansilla A, Salina F. Kinetic study of the malonaldehyde-azulene reaction determination of malonaldehyde in human plasma. Anal. Biochem. 1994; 222: 396–403
  • Esterbauer H, Jurgens G. Mechanistic and genetic aspects of susceptibility of LDL to oxidation. Curr. Opin. Lipidol. 1993; 4: 114–124
  • Esterbauer H, Dieber-Rotheneder M, Waeg G, Striegl G, Jurgens G. Biochemical, structural and functional properties of oxidised low-density lipoprotein. Chem. Res. Toxicol. 1990; 3: 77–92
  • Esterbauer H, Gebicki J, Puhl H, Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad. Biol & Med. 1992; 13: 341–390
  • Esterbauer H, Puhl H, Dieber-Rotheneder M, Waeg G, Rabi H. Effect of antioxidants on oxidative modification of LDL. Ann. Med. 1991a; 23: 573–581
  • Esterbauer H, Schaur R J, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Rad. Biol. Med. 1991b; 11: 81–128
  • Esterbauer H, Striegal G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Rad. Res. Commun. 1989; 6: 67–75
  • Ferns G AA, Konneh M, Anggard E E. Vitamin E: the evidence for an anti-atherogenic role. Artery 1993; 20: 671–694
  • Ferrari R, Ceconi C, Curello S, Cargnoni A, Pasini E, De Giuli F, Albertini A. Role of oxygen free radicals in ischemic and reperfused myocardium. Am. J. Clin. Nutr. 1991; 53: 215S–222S
  • Frankel E N, German J B, Davis P A. Headspace gas chromatography to determine human LDL oxidation. Lipids 1992; 27: 1047–1105
  • Frankel E N, Kanner J, German J B, Parks E, Kinsella J E. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993; 341: 454–457
  • Fraser G E. Diet and coronary heart disease: beyond dietary fats and low-density lipoprotein cholesterol. Am. J. Clin. Nutr. 1994; 59: 1117S–1123S
  • Frei B, England L, Ames B N. Ascorbate is an outstanding antioxidant in human blood plasma. Proc. Natl Acad. Sci. USA 1989; 86: 6377–6381
  • Frei B, Gaziano J M. Content of antioxidants, preformed lipid hydroperoxides and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation. J. Lipid Res. 1993; 34: 2135–2145
  • Frei B, Kim M C, Ames B N. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc. Natl Acad. Sci. 1990; 87: 4879–4883
  • Frei B, Stocker R, Ames B M. Antioxidant defenses and lipid peroxidation in human blood plasma. Proc. Natl Acad. Sci. USA 1988a; 85: 9748–9752
  • Frei B, Yamamoto Y, Niclas D, Ames B N. Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxide in human blood plasma. Anal. Biochem. 1988b; 175: 120–130
  • Frick A H, Manninen V, Huttunen J K, Heinonen O P, Tenkanen L, Manttari M. HDL-cholesterol as a risk factor in coronary heart disease; an update of the Helsinki heart study. Drugs 1990; 40: 7–12
  • Fuster V, Badimon L, Badimon J J, Cheesebro J H. The pathogenesis of coronary artery disease and the acute coronary syndromes. N. Engl. J. Med. 1992; 326: 242–250
  • Garry P J, Vanderjagt D J, Hunt W C. Ascorbic acid intakes and plasma levels in healthy elderly. Ann. NY Acad. Sci. 1987; 498: 90–99
  • Gaziano J M, Hennekens C H. Vitamin antioxidants and cardiovascular disease. Curr. Opin. Lipid. 1992; 3: 291–294
  • Gey K F. Lipids, lipoproteins and antioxidants in cardiovascular disease. Biochem. Soc. Trans. 1990; 18: 1041–1045
  • Gey K F, Puska P. Plasma vitamins E and A inversely correlated to mortality from ischemic heart disease in cross-cultural epidemiology. Ann. NY Acad. Sci. 1989; 570: 268–282
  • Gey K F, Brubacher G B, Stahelin H B. Plasma levels of antioxidant vitamins in relation to ischaemic heart disease and cancer. Am. J. Clin. Nutr. 1987; 45: 1368–1377
  • Gey K F, Moser U K, Jordan P, Stahelin H B, Eichholzer M, Ludin E. Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin. C. Am. J. Clin. Nutr. 1993; 57: 787S–797S
  • Ghiselli A, Serafini M, Maiani G, Azzxini E, Ferro-Luzzi A. A fluorescence-based method for measuring total plasma antioxidant capacity. Free Rad. Biol. Med. 1995; 18: 29–36
  • Ginter E. Marginal vitamin C deficiency, lipid metabolism and atherogenesis. Adv. Lipid Res. 1978; 16: 167–170
  • Goldstein J L, Ho Y K, Basu S K, Brown M S. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl Acad. Sci. USA 1979; 76: 333–337
  • Gopaul N K, Nourooz-Zadeh J, Mallet A I, Anggard E E. Formation of F2-isoprostanes during aortic endothelial cell-mediated oxidation of low density lipoprotein. FEBS Lett. 1994; 348: 297–300
  • Gorog P. Neutrophil-oxidised low density lipoprotein: generation in and clearance from the plasma. Int. J. Exp. Path. 1992; 73: 485–490
  • Greenberg E R, Baron J A, Tosteson T D, Freeman D, Beck G J, Bond J H, Colacchio T A, Coller J A, Frankl H D, Haile R W, Mandel J S, Nierenberg D W, Rothstein R, Snover D C, Stevens M M, Summer R W, Van Stolk R U. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N. Engl. J. Med. 1994; 331: 141–147
  • Grundy S M. Role of low-density lipoproteins in atherogenesis and development of coronary heart disease. Clin. Chem. 1995; 41: 139–146
  • Gutteridge J MC. Aspects to consider when detecting and measuring lipid peroxidation. Free Rad. Res. Commun. 1986; 1: 173–184
  • Gutteridge J MC. Antioxidants, nutritional supplements and life-threatening diseases. Br. J. Biomed. Sci. 1994; 51: 288–295
  • Hallfrisch J, Singh V N, Muller D C, Baldwin H, Bannon M E, Andres R. High plasma vitamin C associated with high plasma HDL- and HDL2 cholesterol. Am. J. Clin. Nutr. 1994; 60: 100–105
  • Halliwell B. How to characterize a biological antioxidant. Free Rad. Res. Commun. 1990; 9: 1–32
  • Halliwell B. Free radicals, antioxidants and human disease: curiosity, cause or consequence. Lancet 1994; 3244: 721–724
  • Halliwell B, Aruoma O I. DNA and Free Radicals. Ellis Horwood., Chichester 1993
  • Halliwell B, Gutteridge J MC. Free Radicals in Biology and Medicine. Oxford University Press., Oxford 1989
  • Halliwell B, Gutteridge J MC. The antioxidants of extracellular fluids. Arch. Biochem. Biophys. 1990; 280: 1–8
  • Halliwell B, Gutteridge J MC. The definition and measurement of antioxidants in biological systems. Free Rad. Biol. Med. 1995; 18: 125–126
  • Hamsten A. Lipids as a coronary risk factor: analysis of hyperlipidaemias. Postgrad Med. J. 1993; 69: S8–S11
  • Harats D, Ben-Naim M, Dabach Y, Hollander G, Havivi E, Stein O, Stein Y. Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking. Atherosclerosis 1990; 85: 47–54
  • Harman D. Aging: a theory based on free radical and radiation chemistry. Gerontology 1956; 11: 298–300
  • Hazell L J, Van Den Berg J J, Stocker R. Oxidation of low density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation. Biochem. J. 1994; 302: 297–304
  • Heinecke J W, Li W, Mueller D M, Bohrer A, Turk J. Cholesterol chlorohydrin synthesis by the myelo-peroxidase-hydrogen peroxide-chloride system: potential markers for lipoproteins oxidatively damaged by phagocytes. Biochemistry 1994; 33: 10127–10136
  • Hemila H. Vitamin C and plasma cholesterol. Crit. Rev. Food Sci. Nutr. 1992; 32: 33–57
  • Hennekens C H, Buring J E, Peto R. Antioxidant vitamins - benefits not yet proved. N. Engl. J. Med. 1994; 330: 1080–1081
  • Hennekens C H, Gaziano J M. Antioxidants and heart disease: epidemiology and clinical evidence. Clin. Cardiol. 1993; 16: 110–115
  • Hennig B, Alvarado A. Nutrition and endothelial cell integrity: implications in atherosclerosis. Progr. Food Nutr. Sci. 1993; 17: 119–157
  • Hogg N, Darley-Usmar V M, Graham A, Monacada S. Peroxynitrite and atherosclerosis. Biochem. Soc. Proc. 1993; 21: 358–362
  • Ikatsu H, Nakahima T, Murayama N, Korenaga T. Flow injection analysis for malondialdehyde in plasma with thiobarbituric acid reaction. Clin. Chem. 1992; 38: 2061–2065
  • Illingworth D R. The potential role of antioxidants in the prevention of atherosclerosis. J. Nutr. Sci. Vitaminol. 1993; 39: S43–S47
  • Ingold K U, Webb A C, Witter D, Burton G W, Metcalf T A, Muller D PR. Vitamin E remains the major lipid-soluble, chain breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Arch. Biochem. Biophys. 1987; 259: 224–225
  • International Taskforce for Prevention of Coronary Heart Disease. Prevention of coronary heart disease: scientific background and clinical guidelines. Nutr. Metab. Cardiovasc. Dis. 1992; 2: 113–156
  • Jacob R A, Kelley D S, Pianalto F S, Swendseid M E, Henning S, Zhang J Z, Ames B N, Fraga C G, Peters J H. Immunocompetence and oxidant defense during ascorbate depletion of healthy men. Am. J. Clin. Nutr. 1991; 54: 1302S–1309S
  • Jacques P F. Relationship of vitamin C status to cholesterol and blood pressure. Ann. NY Acad. Sci. 1992; 669: 205–213
  • Janero D R. Therapeutic potential of vitamin E in the pathogenesis of spontaneous atherosclerosis. Free Rad. Biol. Med. 1991; 11: 129–144
  • Jenner P. Oxidative damage in neurogenerative disease. Lancet 1994; 344: 796–798
  • Jessup W, Dean R T, Gebicki J N. Iodometric determination of hydroperoxides in lipids and proteins. Methods in Enzymology, Vol. 233, part C: Oxygen Radicals in Biological Systems, L. Packer. Academic Press., San Diego 1994; 284–303
  • Jialal I, Fuller C J. Oxidized LDL and antioxidants. Clin. Cardiol. 1993; 16: 16–19
  • Jialal I, Vega G L, Grundy S M. Physiologic levels of ascorbate inhibit oxidative modification of low density lipoprotein. Atherosclerosis 1990; 82: 185–191
  • Jiang Z Y, Woolard A CS, Wolff S P. Lipid hydroperoxide measurement by oxidation of Fe2+ in the presence of xylenol orange. Comparison with the TBA assay and an iodometric assay. Lipids 1991; 26: 853–856
  • Kagan V E, Serbinova E A, Forte T, Scita G, Packer L. Recycling of vitamin E in human low density lipoproteins. J. Lipid Res. 1992; 33: 385–397
  • Kaneko T, Nakano S, Matsuo M. Protective effect of vitamin E on linoleic acid hydroperoxide-induced injury to human endothelial cells. Lipids 1991; 26: 345–348
  • Kleinveld H A, Hak-Lemmers H LM, Stalenhoef A FH, Demacker P NM. Improved measurement of low density-lipoprotein susceptibility to copper-induced oxidation: application of a short procedure for isolating low-density lipoprotein. Clin. Chem. 1992; 38: 2066–2072
  • Kleinveld H A, Naber A HJ, Stalenhoef A FH, Demacker P NM. Oxidation resistance, oxidation rate, and extent of oxidation of human low-density lipoprotein depend on the ratio of oleic acid content to linoleic acid content: studies in vitamin E deficient subjects. Free Rad. Biol. Med. 1993; 15: 273–280
  • Kneepkens C MF, Lepage G, Roy C C. The potential of the hydrocarbon breath test as a measure of lipid peroxidation. Free Rad. Biol. Med. 1994; 17: 127–160
  • Knight J A. Diseases related to oxygen-derived free radicals. Ann. Clin. Lab. Sci. 1995; 25: 1111–1121
  • Knight J A, Pieper R K, McClellan L. Specificity of the thiobarbituric acid reaction; its use in studies of lipid peroxidation. Clin. Chem. 1988; 34: 2433–2438
  • Knight J A, Smith S E, Kinder V E, Anstall H B. Reference intervals for plasma lipoperoxides: age- sex-and specimen-related variations. Clin. Chem. 1987; 33: 2289–2291
  • Krebs H A. The Sheffield experiment on the vitamin C requirement of adults. Proc. Nutr. Soc. 1953; 12: 237–246
  • Lang J, Celotto C, Esterbauer H. Quantitative determination of the lipid peroxidation product 4-hydroxynonenal by high-performance liquid chromatography. Anal. Biochem. 1985; 150: 369–378
  • Levine M, Hartzell W. Ascorbic acid: the concept of optimum requirements. Ann. NY Acad. Sci. 1987; 498: 424–444
  • Levine M, Cantilena C C, Dhariwal K R. In situ kinetics and ascorbic acid requirements. Wld Rev. Nutr. Diet. 1993; 72: 114–127
  • Ma Y S, Stone W L, LeClair I O. The effects of vitamin C and urate on the oxidation kinetics of human low-density lipoprotein. Proc. Soc. Exp. Biol. Med. 1994; 206: 53–59
  • Maggi E, Finardi G, Poli M, Bollati P, Fillipono M, Stefano P L, Paolini G, Grossi A, Clot P, Albano E, Bellomo G. Specificity of autoantibodies against oxidised LDL as an additional marker for atherosclerotic risk. Coron. Art. Dis. 1993; 4: 1119–1122
  • Masarei J RL, Kiiveri H T, Stanton K. Risk factors for cardiovascular disease in a diabetic population. Pathology 1986; 18: 89–93
  • Maxwell S RJ. Can antioxidants prevent ischaemic heart disease. J. Clin. Pharmacol. Therapeut. 1993; 18: 85–95
  • McCord J M. Human disease, free radicals and the oxidant/antioxidant balance. Clin. Biochem. 1993; 26: 351–357
  • Meister A. Commentary on the antioxidant effects of ascorbic acid and glutathione. Biochem. Pharmacol. 1992; 44: 1905–1915
  • Mera S L. Diet and disease. Br. J. Biomed. Sci. 1994; 51: 189–206
  • Meydani M. Vitamin E. Lancet 1995; 345: 170–175
  • Miller N E. HDL metabolism and its role in lipid transport. Eur. Heart J. 1990; 11: H1–H3
  • Miller N J, Rice-Evans C, Davies M J, Gopinathan V, Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin. Sci. 1993; 84: 407–412
  • Morel D W, De La Llera-Moya M, Friday K E. Treatment of cholesterol-fed rabbits with dietary vitamins E and C inhibits lipoprotein oxidation but not development of atherosclerosis. J. Nutr. 1994; 124: 2123–2130
  • Muckle T J, Nazir D J. Variation in human high density lipoprotein response to oral vitamin E dosage. Am. J. Clin. Pathol. 1989; 91: 165–171
  • Mulholland C W, Strain J J. Total radical-trapping antioxidant potential (TRAP) of plasma: effects of supplementation of young healthy volunteers with large doses of alpha tocopherol and ascorbic acid. Int. J. Vit. Nutr. Res. 1993; 63: 27–30
  • Nagelkerke J F, Havekes L, Van Hinsbergh V WM, Van Berkel T JC. In vivo catabolism of biologically modified LDL. Arteriosclerosis 1984; 4: 256–264
  • Naidoo R, Knapp M L. Studies of lipid peroxidation products in cerebrospinal fluid and serum in multiple sclerosis and other conditions. Clin. Chem. 1992; 38: 2449–2454
  • Nair V, Cooper C S, Vietti D E, Turner G A. The chemistry of lipid peroxidation metabolites: crosslinking reactions of malondialdehyde. Lipids 1986; 21: 6–10
  • Naito C, Kawamura M, Yamamoto Y. Lipid peroxides as the initiating factor of atherosclerosis. Ann. NY Acad. Sci. 1993; 676: 27–45
  • Nicki E. Interaction of ascorbic acid and alpha tocopherol. Ann. NY Acad. Sci. 1987; 498: 186–199
  • Ohrvall M, Tengblad S, Ekstrand B, Siegbahn A, Vessby B. Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. Atherosclerosis 1994; 108: 103–110
  • Packer L. New horizons in vitamin E research - the vitamin E cycle, biochemistry and clinical applications. Lipid Soluble Antioxidants: Biochemistry and Clinical Applications, ASH Ong, L Packer. Birkhauser., Basel 1992a; 1–16
  • Packer L. Interactions among antioxidants in health and disease: vitamin E and its redox cycle. Proc. Soc. Exp. Biol. 1992b; 200: 271–276
  • Packer L. Methods in Enzymology, Vol. 233, part C: Oxygen Radicals in Biological Systems. Academic Press., San Diego 1994
  • Packer L, Glazer A N. Methods in Enzymology, Vol. 186, part B: Oxygen Radicals and Antioxidants. Academic Press., San Diego 1990
  • Parthasarathy S, Barnett J, Fong L G. High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim. Biophys. Acta 1989; 1044: 275–283
  • Parthasarathy S, Khoo J C, Miller E, Barnett H J, Witzum J L, Steinberg D. Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis. Proc. Natl Acad. Sci. USA 1990; 87: 3894–3898
  • Parthasarathy S, Steinberg D, Witzum J L. The role of oxidised low-density lipoproteins in the pathogenesis of atherosclerosis. Ann. Rev. Med. 1992; 43: 219–225
  • Plachta H, Bartnikowska E, Obara A. Lipid peroxides in blood from patients with atherosclerosis of coronary and peripheral arteries. Clin. Chim. Acta 1992; 211: 101–112
  • Popov I N, Lewin G. Photochemiluminescent detection of antiradical activity: II testing of nonenzymic water-soluble antioxidants. Free Rad. Biol. Med. 1994; 17: 267–271
  • Prasad K N, Edwards-Prasad J. Vitamin E and cancer prevention: recent advances and future potentials. J. Am. Coll. Nutr. 1992; 11: 487–500
  • Prasad K, Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am. Heart J. 1993; 125: 958–973
  • Pré J. Plasma measurement of xylenol orange reactive substances; normal values in non-smokers and smokers. Med. Sci. Res. 1993; 21: 185–186
  • Pré J, Le Floch A, Vassy R, Le Noble C. Increased plasma level of fluorescent lipid-peroxidation products in cigarette smokers. Med. Sci. Res. 1989; 17: 1029–1030
  • Princen H MG, Van Duyvenvoorde W, Van der Buytenhek R., Larse A, Van Poppel G, Gevers Leuven J A, Van Hinsbergh V WM. Supplementation with low doses of vitamin E protects LDL from lipid peroxidation in men and women. Arterioscler. Thromb. Vasc. Biol. 1995; 15: 325–333
  • Raal F J, Areias A J, Pilcher G J, Joffe B I, Seftel H C. Lack of effect of high dose vitamin E on xanthoma regression in homozygous familial hypercholesterolamia. Atherosclerosis 1994; 107: 213–219
  • Reaven P D, Grasse B J, Tribble D L. Effects of linoleate-enriched diets in combination with alpha tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. Arterioscler. Thromb. 1994; 14: 557–566
  • Regnstrom J, Nilsson J. Lipid oxidation and inflammation-induced intimal fibrosis in coronary heart disease. J. Lab. Clin. Med. 1994; 124: 168
  • Retsky K L, Freeman M W, Frei B. Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. J. Biol. Chem. 1993; 268: 1304–1309
  • Rice-Evans C A, Diplock A T. Current status of antioxidant therapy. Free Rad. Biol. Med. 1993; 15: 77–96
  • Rice-Evans C A, Diplock A T, Symons M CR. Laboratory Techniques in Biochemistry and Molecular Biology, Vol. 22: Techniques in Free Radical Research. Elsevier., London 1991
  • Richard M J, Portal B, Meo J, Coudray C, Hadjian A, Favier A. Malondialdehyde kit evaluated for determining plasma and lipoprotein fractions that react with thiobarbituric acid. Clin. Chem. 1992; 38: 710–709
  • Riemersma R A. Epidemiology and the role of antioxidants in preventing coronary heart disease; a brief overview. Proc. Nutr. Soc. 1994; 57: 787S–997S
  • Riemersma R A, Wood D A, MacIntyre C CA, Elton R A, Gey K F, Oliver N F. Risk of angina pectoris and plasma concentrations of vitamins A, C, E and carotene. Lancet 1991; 53: 1–9
  • Rifkind B M. High density lipoprotein and coronary heart disease: survey of the evidence. Am. J. Cardiol. 1990; 66: 3A–6A
  • Rimm E B, Stampfer M J, Ascherio A, Giovannucci E, Colditz G A, Willett W C. Vitamin E consumption and risk of coronary heart disease in men. N. Engl. J. Med. 1993; 328: 1450–1456
  • Rifici V A, Khachadurian A K. The inhibition of low density lipoprotein oxidation by 17 beta oestradiol. Metabolism 1992; 41: 1110–1114
  • Rivers J M. Safety of high level vitamin C ingestion. Ann. NY Acad. Sci. 1987; 498: 445–454
  • Roberts L J, Morrow J D. Isoprostanes: novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury. Ann. NY Acad. Sci. 1994; 744: 237–242
  • Roheim P S, Asztalos B F. Clinical significance of lipoprotein size and risk for coronary atherosclerosis. Clin. Chem. 1995; 41: 147–152
  • Ross R. Atherosclerosis: current understanding of mechanisms and future strategies in therapy. Transplant. Proc. 1993; 25: 2041–2043
  • Salonen J T, Yla-Herttuala S, Yamamoto R, Butler S, Korpela H, Salonen R, Nyyssonen K, Palinski W, Witzum J L. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 1992; 339: 883–887
  • Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colourimetric method. Clin. Chim. Acta 1978; 90: 37–43
  • Schafer L, Thorling E B. Lipid peroxidation and antioxidant supplementation in old age. Scand. J. Clin. Invest. 1990; 50: 69–70
  • Schorah C J. The transport of vitamin C and effects of disease. Proc. Nutr. Soc. 1992; 51: 189–198
  • Schwartz J L, Antoniades D Z, Zhao S. Molecular and biochemical reprogramming of oncogenesis through the activity of prooxidants and antioxidants. Ann. NY Acad. Sci. 1993; 686: 262–278
  • Sevanian A, Hochstein P. Mechanisms and consequences of lipid peroxidation in biological systems. Ann. Rev. Nutr. 1985; 5: 365–390
  • Sevanian A, Davies K JA, Hochstein P. Serum urate as an antioxidant for ascorbic acid. Am. J. Clin. Nutr. 1991; 54: 1129S–1134S
  • Shafar J. Rapid reversion of electrocardiographic abnormalities after treatment in two cases of scurvy. Lancet 1967; 2: 176
  • Sharov V S, Kazamanov V A, Vladimirov Y A. Selective sensitisation of chemiluminescence resulted from lipid and oxygen radical reactions. Free Rad. Biol. Med. 1989; 7: 237–242
  • Shimasaki H, Hirai N, Ueta N. Comparison of fluorescence characteristics of products of peroxidation of membrane phospholipids with those of products derived from reaction of malonaldehyde with glycine as a model of lipofuscin fluorescent substances. J. Biochem. 1988; 104: 761–766
  • Simon J A. Vitamin C and cardiovascular disease: a review. J. Am. Coll. Nutr. 1992; 11: 107–125
  • Sinclair A J, Girling A J, Gray L, Lunec J, Barnett A H. An investigation of the relationship between free radical activity and vitamin C metabolism in elderly diabetic subjects with retinopathy. Gerontology 1992; 38: 268–274
  • Smith D, O'Leary V J, Darley-Usmar V M. The role of alpha tocopherol as a peroxyl radical scavenger in human low density lipoprotein. Biochem. Pharmacol. 1993; 45: 2195–2201
  • Stampfer M J, Hennekens C H, Manson J E, Colditz G A, Rosner B, Willett W C. Vitamin E consumption and the risk of coronary heart disease in women. N. Engl. J. Med. 1993; 328: 1444–1449
  • Steinberg D. Antioxidants in the prevention of human atherosclerosis. Circulation 1992; 85: 2338–2344
  • Steinberg D. Antioxidant vitamins and coronary heart disease. N Engl. J. Med. 1993; 328: 1487–1489
  • Steinberg D, Witzum J L. Lipoproteins and atherogenesis; current concepts. J. Am. Med. Assoc. 1990; 264: 3047–3052
  • Steinberg D, Parthasarathy S, Carew T E, Khoo J C, Witzum J L. Beyond cholesterol; modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 1989; 320: 915–924
  • Stocker R. Lipoprotein oxidation: mechanistic aspects, methodological aspects and clinical relevance. Curr. Opin. Lipidol. 1994; 5: 422–433
  • Sullivan J L. Antioxidant effects of iron depletion. Free Rad. Biol. Med. 1994; 17: 87
  • Swain J A, Darley-Usmar V, Gutteridge J M. Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosis. FEBS Lett. 1994; 342: 49–52
  • Tarr M, Samson F. Oxygen Free Radicals in Tissue Damage. Birkhauser., Boston 1993
  • The Alpha Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 1994; 330: 1029–1035
  • Tolonen M, Sarna S, Halme M, Tuominen S E, Westermarck T, Nordberg U, Keinonen M, Schrijver J. Antioxidant supplementation decreases TBA reactants in serum of elderly. Biol. Trace Element Res. 1988; 17: 221–228
  • Traber M G. Determinants of plasma vitamin E concentrations. Free Rad. Biol. Med. 1994; 16: 229–239
  • Tsuchida M, Miura T, Mizutani K, Aibara K. Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. Biochim. Biophys. Acta 1985; 834: 196–204
  • Valstar E. Nutrition and cancer: a review of the preventive and therapeutic abilities of single nutrients. J. Nutr. Med. 1994; 4: 179–198
  • Van den Berg J, Winterbourne C. Measurement of reaction products from hypochlorous acid and unsaturated lipids. Methods in Enzymology, Vol. 233, part C: Oxygen Radicals in Biological Systems, L Packer. Academic Press., San Diego 1994; 639–649
  • Van der Vliet A, O'Neill C A, Halliwell B, Cross C E, Kaur H. Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evidence for hydroxyl radical production from peroxynitrite. FEBS Lett. 1994; 339: 89–92
  • VanderJagt D J, Garry P J, Bhagavan H N. Ascorbic acid intake and plasma levels in healthy elderly people. Am. J. Clin. Nutr. 1987; 46: 290–294
  • Verlangieri A J, Bush M. Prevention and regression of atherosclerosis by alpha tocopherol. J. Am. Coll. Nutr. 1992; 11: 131–138
  • Virella G, Virella I, Leman R B, Pryor M B, Lopes-Virella M F. Anti-oxidised low-density lipoprotein antibodies in patients with coronary heart disease and normal healthy volunteers. Int. J. Clin. Lab. Res. 1993; 23: 95–101
  • Vladimirov Y A, Sharov V S, Suslova T B. Eu3+-tetracyclin complex activates chemiluminescence accompanying lipid peroxidation in liposomes. Photobiochem. Photobiophys. 1981; 2: 279–284
  • Wandzilak T R, D'Andre S D, Davis P A, Williams H E. Effect of high dose vitamin C on urinary oxalate levels. J. Urol. 1994; 151: 834–837
  • Wang Y H, Dhariwal K R, Levine M. Ascorbic acid bioavailability in humans. Ann. NY Acad. Sci 1992; 669: 383–386
  • Wartanowicz M, Panczenko-Kresowska B, Ziemlanski S, Kowlaska M, Okolska G. The effect of alpha tocopherol on the serum lipid peroxide level in elderly people. Ann. Nutr. Metab. 1984; 28: 186–191
  • Wayner D DM, Burton G W, Ingold K U, Barclay L RC, Locke S J. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochim. Biophys. Acta 1987; 924: 408–419
  • Weisburger J H. Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants and carotenoids. Am. J. Clin. Nutr. 1991; 53: 226S–237S
  • Weiss J N, Goldhaber J I, Ji S en. Oxygen free radicals in the pathophysiology of myocardial ischaemia/reperfusion. Oxygen Free Radicals in Tissue Damage, M Tarr, F Samson. Birkhauser., Boston 1993; 250–266
  • Wennmalm Å. Endothelial nitric oxide and cardiovascular disease. J. Int. Med. 1994; 235: 317–327
  • Whitehead T P, Robinson D, Allaway S, Syms J, Hale A. Effect of red wine on the antioxidant capacity of serum. Clin. Chem. 1995; 41: 32–35
  • Whitehead T P, Thorpe G HG, Maxwell S RJ. Enhanced chemiluminescent assay for antioxidant capacity in biological fluids. Anal. Chim. Acta 1992; 266: 265–277
  • Willis G C. An experimental study of the intimal ground substance in atherosclerosis. Can. Med. Assoc. J. 1953; 17: 17–22
  • Wolff S A. Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods in Enzymology, Vol. 233, part C: Oxygen Radicals in Biological Systems, L Packer. Academic Press., San Diego 1994; 182–189
  • Wong H Y, Knight J A, Hopfer S M, Zaharia O, Leach CN, Jr, Sunderman FW, Jr. Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin. Chem. 1987; 33: 214–220
  • Woodard D A, Limacher M C. The impact of diet on coronary heart disease. Clin. Nutr. 1993; 77: 849–862
  • World Health Organisation. The WHO MONICA Project. Wld Health Stat. Q. 1989; 42: 27–149
  • Yagi K. Assay for serum lipid peroxide level and its clinical significance. Lipid Peroxides in Biology and Medicine, K Yagi. Academic Press., San Diego 1982; 223–242
  • Yamamoto Y, Brodsky M H, Baker J C, Ames B N. Detection and characterisation of lipid hydroperoxides at picomole levels by high performance liquid chromatography. Anal. Biochem. 1987; 160: 7–13
  • Young S G, Parthasarathy S. Why are low-density lipoproteins atherogenic. W. J. Med. 1994; 160: 153–164
  • Yu B Y. Cellular defenses against damage from reactive oxygen species. Physiol. Rev. 1994; 74: 139–162
  • Yue D K, McLennan S, Fisher E, Hefferman S, Capogreco C, Ross G R, Turtle J R. Ascorbic acid metabolism and the polyol pathway in diabetes. Diabetes 1989; 38: 257–261

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