920
Views
28
CrossRef citations to date
0
Altmetric
PAPERS

DHHC20: a human palmitoyl acyltransferase that causes cellular transformation

&
Pages 123-136 | Received 14 Sep 2009, Accepted 05 Jan 2010, Published online: 25 Mar 2010

References

  • Resh MD. 2006. Palmitoylation of ligands, receptors, and intracellular signaling molecules. Sci STKE 2006359:re14.
  • Linder ME,Deschenes RJ. 2007. Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol 81:74–84.
  • Greaves J,Chamberlain LH. 2007. Palmitoylation-dependent protein sorting. J Cell Biol 1763:249–54.
  • Milligan G, Parenti M, Magee AI. 1995. The dynamic role of palmitoylation in signal transduction. Trends Biochem Sci 205:181–187.
  • Dudler T,Gelb MH. 1996. Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes. J Biol Chem 27119:11541–11547.
  • Mumby SM. 1997. Reversible palmitoylation of signaling proteins. Curr Opin Cell Biol 92:148–154.
  • Kosugi A, Hayashi F, Liddicoat DR, Yasuda K, Saitoh S, Hamaoka T. 2001. A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation. Immunol Lett 762:133–138.
  • Gelb MH, Brunsveld L, Hrycyna CA, Michaelis S, Tamanoi F, Van Voorhis WC, Waldmann H. 2006. Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol 210:518–528.
  • Resh MD. 1999. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta 14511:1–16.
  • Resh MD. 1996. Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins. Cell Signal 86:403–412.
  • Hancock JF, Magee AI, Childs JE, Marshall CJ. 1989. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 577:1167–1177.
  • Eungdamrong NJ,Iyengar R. 2007. Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi. Biophys J 923:808–815.
  • Pechlivanis M, Kuhlmann J. 2006. Hydrophobic modifications of Ras proteins by isoprenoid groups and fatty acids – more than just membrane anchoring. Biochim Biophys Acta 176412:1914–1931.
  • Sandilands E, Brunton VG, Frame MC. 2007. The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J Cell Sci 120Pt 15:2555–2564.
  • Downward J. 2003. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 31:11–22.
  • Shi M, Cooper JC, Yu CL. 2006. A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation. Mol Cancer Res 41:39–45.
  • Leonard DM. 1997. Ras farnesyltransferase: a new therapeutic target. J Med Chem 4019:2971–2990.
  • Chen WJ, Andres DA, Goldstein JL, Russell DW, Brown MS. 1991. cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1. Cell 662:327–334.
  • Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompliano DL, Graham SL, Smith RL, Scolnick EM, Oliff A, Gibbs JB. 1993. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 2605116:1934–1937.
  • Lobo S, Greentree WK, Linder ME, Deschenes RJ. 2002. Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J Biol Chem 27743:41268–41273.
  • Roth AF, Feng Y, Chen L, Davis NG. 2002. The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J Cell Biol 1591:23–28.
  • Smotrys JE, Schoenfish MJ, Stutz MA, Linder ME. 2005. The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. J Cell Biol 1707:1091–1099.
  • Valdez-Taubas J, Pelham H. 2005. Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. Embo J 2414:2524–2532.
  • Emmer BT, Souther C, Toriello KM, Olson CL, Epting CL, Engman DM. 2009. Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane. J Cell Sci 122(Pt 6):867–874.
  • Buglino JA, Resh MD. 2008. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem 28332:22076–22088.
  • Fernandez-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC. 2006. Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol 1743:369–377.
  • Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS. 2004. Identification of PSD-95 palmitoylating enzymes. Neuron 446:987–996.
  • Ducker CE, Stettler EM, French KJ, Upson JJ, Smith CD. 2004. Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. Oncogene 2357:9230–9237.
  • Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME. 2005. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J Biol Chem 28035:31141–31148.
  • Sharma C, Yang XH, Hemler ME. 2008. DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Mol Biol Cell 19:3415–3425.
  • Zhang J, Planey SL, Ceballos C, Stevens SM, Jr., Keay SK, Zacharias DA. 2008. Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. Mol Cell Proteomics 77:1378–1388.
  • Dunphy JT, Greentree WK, Manahan CL, Linder ME. 1996. G-protein palmitoyltransferase activity is enriched in plasma membranes. J Biol Chem 27112:7154–7159.
  • Liu L, Dudler T, Gelb MH. 1996. Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide. J Biol Chem 27138:23269–23276.
  • Draper JM, Xia Z, Smith CD. 2007. Cellular palmitoylation and trafficking of lipidated peptides. J Lipid Res 488:1873–1884.
  • Hou H, Subramanian K, LaGrassa TJ, Markgraf D, Dietrich LE, Urban J, Decker N, Ungermann C. 2005. The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. Proc Natl Acad Sci USA 10248:17366–17371.
  • Ohno Y, Kihara A, Sano T, Igarashi Y. 2006. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim Biophys Acta 17614:474–483.
  • Varner AS, Ducker CE, Xia Z, Zhuang Y, De Vos ML, Smith CD. 2003. Characterization of human palmitoyl-acyl transferase activity using peptides that mimic distinct palmitoylation motifs. Biochem J 373(Pt 1): 91–99.
  • Varner AS, De Vos ML, Creaser SP, Peterson BR, Smith CD. 2002. A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity. Anal Biochem 3081:160–167.
  • Schroeder H, Leventis R, Shahinian S, Walton PA, Silvius JR. 1996. Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells. J Cell Biol 1343:647–660.
  • Creaser SP, Peterson BR. 2002. Sensitive and rapid analysis of protein palmitoylation with a synthetic cell-permeable mimic of SRC oncoproteins. J Am Chem Soc 12411:2444–2445.
  • Peters C, Wagner M, Volkert M, Waldmann H. 2002. Bridging the gap between cell biology and organic chemistry: chemical synthesis and biological application of lipidated peptides and proteins. Naturwissenschaften 899:381–390.
  • Ducker CE, Griffel LK, Smith RA, Keller SN, Zhuang Y, Xia Z, Diller JD, Smith CD. 2006. Discovery and characterization of inhibitors of human palmitoyl acyltransferases. Mol Cancer Ther 57:1647–1659.
  • Shalloway D, Coussens PM, Yaciuk P. 1984. Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells. Proc Natl Acad Sci USA 8122:7071–7075.
  • Tao WJ, Lin H, Sun T, Samanta AK, Arlinghaus R. 2008. BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor. Oncogene 2722:3194–3200.
  • Meyn MA, 3rd, Wilson MB, Abdi FA, Fahey N, Schiavone AP, Wu J, Hochrein JM, Engen JR, Smithgall TE. 2006. Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. J Biol Chem 28141:30907–30916.
  • Pecquet C, Nyga R, Penard-Lacronique V, Smithgall TE, Murakami H, Regnier A, Lassoued K, Gouilleux F. 2007. The Src tyrosine kinase Hck is required for Tel-Abl- but not for Tel-Jak2-induced cell transformation. Oncogene 2611:1577–1585.
  • Thomas SM, Brugge JS. 1997. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13:513–609.
  • Belsches-Jablonski AP, Biscardi JS, Peavy DR, Tice DA, Romney DA, Parsons SJ. 2001. Src family kinases and HER2 interactions in human breast cancer cell growth and survival. Oncogene 2012:1465–1475.
  • Reissig D, Clement J, Sanger J, Berndt A, Kosmehl H, Bohmer FD. 2001. Elevated activity and expression of Src-family kinases in human breast carcinoma tissue versus matched non-tumor tissue. J Cancer Res Clin Oncol 1274:226–230.
  • Han NM, Curley SA, Gallick GE. 1996. Differential activation of pp60(c-src) and pp62(c-yes) in human colorectal carcinoma liver metastases. Clin Cancer Res 28:1397–1404.
  • Nakamura K, Chijiiwa Y, Nawata H. 1996. Augmented expression of LCK message directed from the downstream promoter in human colorectal cancer specimens. Eur J Cancer 32A8:1401–1407.
  • Park J, Meisler AI, Cartwright CA. 1993. c-Yes tyrosine kinase activity in human colon carcinoma. Oncogene 810:2627–2635.
  • Veillette A, Foss FM, Sausville EA, Bolen JB, Rosen N. 1987. Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res 14:357–374.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.