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Original Article

Characterization of an 11,000-Dalton β-Bungarotoxin: Binding and Enzyme Activity on Rat Brain Synaptosomal Membranes

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Pages 367-391 | Published online: 09 Jul 2009

References

  • Abe T., Alema S., Miledi R. Phospholipase activity in β-bungarotoxin action. J. Physiol. (Lond.) 1977; 270: 55P–56P
  • Abe T., Limbrick A. R., Miledi R. Acute muscle denervation induced by β-bungarotoxin. Proc. R. Soc. Lond. B 1976; 194: 545–553
  • Chang C. C., Huang M. C. Comparison of the presynaptic actions of Botulinum toxin and β-bungarotoxin on neuromuscular transmission. Naunyn-Schmeideberg's Arch. Pharmacol. 1974; 282: 129–142
  • Chang C. C., Lee C.-Y. Isolation of neurotoxins from the venom of Bungarus multicinctus and their modes of neuromuscular blocking action. Arch. Intern. Pharmacodyn. Therap. 1963; 144: 241–257
  • Chang C. C., Su M. J., Lee J. D., Eaker D. Effects of Sr2+ and Mg2+ on the phospholipase A and the presynaptic neuromuscular blocking actions of β-bungarotoxin, crotoxin and taipoxin. Naunyn-Schmeideberg's Arch. Pharmacol. 1977; 299: 155–162
  • Cleland W. W. The statistical analysis of enzyme kinetic data. Advances in Enzymology, F. F. Nord. Interscience Publishers, New York 1967; Vol. 29: 1–32
  • Dryden W. F., Harvey A. L., Marshall I. G. Pharmacological studies on the bungarotoxins: Separation of the fractions and their neuromuscular activity. Eur. J. Pharmacol. 1974; 26: 256–261
  • Fambrough D. M., Hartzell H. C. Acetylcholine receptors: number and distribution at neuromuscular junctions in a rat diaphragm. Science 1972; 176: 189–191
  • Gray E. G., Whittaker V. P. The isolation of nerve endings from brain: An electron-microscopic study of cell fragments derived by homogenization and centrifugation. J. Anat. Lond. 1962; 96: 79–88
  • Howard B. D. Effects of β-bungarotoxin on mitochondrial respiration are caused by associated phospholipase A activity. Biochem. Biophys. Res. Commun. 1975; 67: 58–65
  • Howard B. D., Troug R. Relationship between the neurotoxicity and phospholipase A activity of β-bungarotoxin. Biochemistry 1977; 16: 122–125
  • Howard B. D., Wu W. C. S. Evidence that β-bungarotoxin acts at the exterior of nerve terminals. Brain Res. 1976; 103: 190–192
  • Kelly R. B., Brown F. R., III. Biochemical and physiological properties of a purified snake venom neurotoxin which acts presynaptically. J. Neurobiol. 1974; 5: 135–150
  • Kelly R. B., Oberg S. G., Strong P. N., Wagner G. M. β-bungarotoxin, a phospholipase that stimulates transmitter release. Cold Spring Harbor Symposium. 1976; Vol. XL: 117–125
  • Lau Y. H., Chiu T. H., Caswell A. H., Potter L. T. Effects of β-bungarotoxin on calcium uptake by sarcoplasmic reticulum from rabbit skeletal muscle. Biochem. Biophys. Res. Commun. 1974; 61: 510–516
  • Lee C.-Y., Chang S. L., Kau S. T., Luh S. H. Chromatographic separation of the venom of Bungarus multicinctus and characterization of its components. J. Chromatogr. 1972; 72: 71–82
  • Livengood D. R., Manalis R. S., Donlon M. A., Masukawa L. M., Tobias G. S., Shain W. Blockade of neuromuscular transmission by enzymatically active and inactive β-bungarotoxin. Proc. Natl. Acad. Sci. USA 1978; 75: 1029–1033
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265–275
  • Meunier J. C., Sealock R., Olsen R., Changeux J.-P. Purification and properties of the cholinergic receptor protein from Electrophorus electricus electric tissue. Eur. J. Biochem. 1974; 45: 371–394
  • Miledi R., Molinoff P., Potter L. T. Isolation of the cholinergic receptor protein of Torpedo electric tissue. Nature 1971; 229: 554–557
  • Nieuwenhuizen W., Kunze H., deHaas G. H. Phospholipase A2) phosphatide acetylhydrolase, E.C. 3.1.1.4) from porcine pancreas. Methods in Enzymology, S. Fleischer, E. L. Parker. Academic Press, New York 1974; Vol. 32: 147–154
  • Oberg S. G., Kelly R. B. Saturable binding to cell membranes of the presynaptic neurotoxin, β-bungarotoxin. Biochim. Biophys. Acta 1976; 433: 662–673
  • Oberg S. G., Kelly R. B. The mechanism of β-bungarotoxin action. I. Modification of transmitter release at the neuromuscular junction. J. Neurobiol. 1976; 7: 129–141
  • Shain W. G., Hilfer S. R., Fonte V. G. Early organogenesis of the embryonic chick thyroid. I. Morphology and biochemistry. Develop. Biol. 1972; 28: 202–218
  • Strong P. N., Goerke J., Oberg S. G., Kelly R. B. β-bungarotoxin, a presynaptic toxin with enzymatic activity. Proc. Natl. Acad. Sci. USA 1976; 73: 178–182
  • Strong P. N., Heuser J. E., Kelly R. B. Selective enzymatic hydrolysis of nerve terminal phospholipid by β-bungarotoxin: Biochemical and morphological studies. Cellular Neurobiology. Alan R. Liss, New York 1977; 227–249
  • Tobias G. S., Donlon M. A., Catravas G. N., Shain W. Purification and biochemical characterization of an 11,000-dalton β-bungarotoxin. Biochim. Biophys. Acta. 1978, In press
  • Tsai M.-C. Ph.D. thesis, National Taiwan University, TaipeiTaiwan 1975
  • Vogel Z., Sytkowski A. J., Nirenberg M. W. Acetylcholine receptors of muscle grown in vitro. Proc. Natl. Acad. Sci. USA 1972; 69: 3180–3184
  • Wagner G. M., Mart P. E., Kelly R. B. β-bungarotoxin inhibition of calcium accumulation by rat brain mitochondria. Biochem. Biophys. Res. Commun. 1974; 58: 475–481
  • Wernicke J. F., Vanker A. D., Howard B. D. The mechanism of action of β-bungarotoxin. J. Neurochem. 1975; 25: 483–496

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