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Intracellular uptake, transport, and processing of gold nanostructures

Pages 299-311 | Received 12 Feb 2010, Accepted 04 Jul 2010, Published online: 07 Oct 2010

References

  • Alivisatos P. 2003. The use of nanocrystals in biological detection. Nat Biotechnol 22:47–51.
  • Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD. 2009. Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects. Small 5:701–708.
  • Aoyama Y, Kanamori T, Nakai T, Sasaki T, Horiuchi S, Sando S, Niidome T. 2003. Artificial viruses and their application to gene delivery. size-controlled gene coating with glycocluster nanoparticles. J Am Chem Soc 125:3455–3457.
  • Arnida MA, Ghandehari H. 2009. Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres. J Appl Toxicol 30:212–217.
  • Aubin-Tam M-E, Hamad-Schifferli, K. 2005. Gold nanoparticle−cytochrome c complexes: the effect of nanoparticle ligand charge on protein structure. Langmuir 21:12080–12084.
  • Aubin-Tam M-E, Hamad-Schifferli, K. 2008. Structure and function of nanoparticle-protein conjugates. Biomed Mater 3:034001.
  • Bao G, Bao XR. 2005. Shedding light on the dynamics of endocytosis and viral budding. Proc Natl Acad Sci USA 102:9997–9998.
  • Bergen JM, van Recum HA, Goodman TT, Massey AP, Pun SH. 2006. Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery. Macromol Biosci 6:506–516.
  • Berry CC, de la Fuente JM, Mullin M, Chu SWL, Curtis ASG. 2007. Nuclear localization of HIV-1 tat functionalized gold nanoparticles. IEEE Trans NanoBiosci 6:262–269.
  • Brown SD, Nativo P, Smith J-A, Stirling D, Edwards PR, Venugopal B, Flint DJ, Plumb JA, Graham D, Wheate NJ. 2010. Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. J Am Chem Soc 132:4678–4684.
  • Cai W, Gao T, Hong H, Sun J. 2008. Applications of gold nanoparticles in cancer nanotechnology. Nanotechnol Sci Appl 1:17–32.
  • Carrot G, Valmalette JC, Plummer CJG, Scholz SM, Dutta J, Hofmann H, Hilborn JG. 1998. Gold nanoparticle synthesis in graft copolymer micelles. Colloid Polym Sci 276:853–859.
  • Cartiera MS, Johnson KM, Rajendran V, Caplan MJ, Saltzman WM. 2009. The uptake and Intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials 30:2790–2798.
  • Chen J, Irudayaraj J. 2009. Quantitative investigation of compartmentalized dynamics of ErbB2 targeting gold nanorods in live cells by single molecule spectroscopy. ACS Nano 3:4071–4079.
  • Chithrani BD, Chan WCW. 2007. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett 7:1542–1550.
  • Chithrani BD, Dunne M, Stewart J, Allen C, Jaffray DA. 2009a. Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier. Nanomedicine 6:161–169.
  • Chithrani BD, Ghazani AA, Chan WCW. 2006. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 6:662–668.
  • Chithrani BD, Jelveh S, Jalali F, Van Prooijen M, Allen C, Bristow RG, Hill RP, Jaffray DA. 2010. Gold nanoparticles as a radiation sensitizer in cancer therapy. Radiat Res 173:719–728.
  • Chithrani BD, Stewart J, Allen C, Jaffray DA. 2009b. Intracellular uptake, transport, and processing of nanostructures in cancer cells. Nanomedicine 5:118–127.
  • Cho EC, Xie J, Wurm PA, Xia Y. 2009. Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant. Nano Lett 9:1080–1084.
  • Choi CHJ, Alabi CA, Webster P, Davis ME. 2010. Mehanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc Natl Acad Sci USA 107:1235–1240.
  • Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD. 2005. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1:325–327.
  • Cordonnier M-N, Dauzonne D, Louvard D, Coudrier E. 2001. Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes. Mol Biol Cell 12:4013–4029.
  • De la Fuente JM, Berry CC. 2005. Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus. Bioconjugate Chem 16:1176–1180.
  • Derfus AM, Chan WCW, Bhatia SN. 2004. Intracellular delivery of quantum dots for live cell labeling and organelle tracking. Adv Mater 16:961–966.
  • El-Sayed IH, Huang X, El-Sayed MA. 2005. Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. Nano Lett 5:829–834.
  • El-Sayed IH, Huang X, El-Sayed MA. 2006. Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles. Cancer Lett 239:129–135.
  • Faraday M. 1857. Experimental relations of gold (and other metals) to light. Philos Trans R Soc London 147:145–181.
  • Feldherr C, Kallenbach E, Schultz N. 1984. Movement of a karyophilic protein through the nuclear pores of oocytes. J Cell Biol 99:2216–2222.
  • Feldherr CM, Lanford RE, Akin D. 1992. Signal-mediated nuclear transport in simian-virus 40- transformed cells is regulated by large tumor-antigen. Proc Natl Acad Sci USA 89:11002–11005.
  • Frens G. 1973. Controlled nucleation for the particle size in monodisperse gold suspensions. Nature 241:20–22.
  • Gao H, Shi W, Freund LB. 2005. Mechanics of receptor-mediated endocytosis. Proc Natl Acad Sci USA 102:9469–9474.
  • Garcia ME, Baker LA, Crooks RM. 1999. Preparation and characterization of dendrimer-gold colloid nanocomposites. Anal Chem 71:256–258.
  • Goldstein JL, Anderson RGW, Brown MS. 1979. Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature 279:679–685.
  • Hainfeld JF, Slatkin DN, Focella TM, Smilowitz HM. 2006. Gold nanoparticles: a new X-ray contrast agent. Br J Radiol 79:248–253.
  • Hainfeld JF, Slatkin DN, Smilowitz HM. 2004. The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol 49:N309–N315.
  • Han G, You C-C, Kim B-J, Turingan RS, Forbes NS, Martin CT, Rotello VM. 2006. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed 45:3165–3169.
  • Hauck TS, Ghazani AA, Chan WCW. 2008. Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells. Small 4:153–159.
  • Huang X, El-Sayed IH, Qian W, El-Sayed MA. 2006. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128:2115–2120.
  • Huff TB, Hansen MN, Zhao Y, Chen J-X, Wei A. 2007. Controlling the cellular uptake of gold nanorods. Langmuir 23:1596–1599.
  • Ishida O, Maruyama K, Sasaki K, Iwatsuru M. 1999. Size-dependent extravasation and interstitial localization of polyethyleneglycol liposomes in solid tumor-bearing mice. Int J Pharm 190:49–56.
  • Ji X, Song X, Li J, Bai Y, Yang W, Peng X. 2007. Size control of gold nanocrystals in citrate reduction: the third role of citrate. J Am Chem Soc 129:13939–13948.
  • Jiang W, Kim BYS, Rutka JT, Chan WCW. 2008. Nanoparticle-mediated cellular response is size-dependent. Nat Nanotechnol 3:145–150.
  • Jin H, Heller DA, Strano MS, Sharma R, Strano MS. 2009. Size-dependent cellular uptake and expulsion of single-walled carbon nanotubes: single particle tracking and a generic uptake model for nanoparticles. ACS Nano 3:149–158.
  • Jin H, Heller DA, Strano MS. 2008. Single-particle tracking of endocytosis and exocytosis of single-walled carbon nanotubes in NIH-3T3 cells. Nano Lett 8:1577–1585.
  • Kam NWS, Jessop TC, Wender PA, Dai H. 2004. Nanotube molecular transporters: internalization of carbon nanotube−protein conjugates into mammalian cells. J Am Chem Soc 126:6850–6851.
  • Kam NWS, Liu Z, Dai H. 2006. Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway. Angew Chem Int Ed 45:577–581.
  • King SJ, Schroer TA. 2000. Dynactin increases the processivity of the cytoplasmic dynein motor Nat Cell Biol 2:20–24.
  • Kirchhausen T. 2000. Three ways to make a vesicle. Nat Rev Mol Cell Biol 1:187–198.
  • Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K. 2006. In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates. Nano Lett 6:2225–2231.
  • Kulkarni RP, Castelino K, Majumdar A, Fraser SE. 2006. Intracellular transport dynamics of endosomes containing DNA polyplexes along the microtubule network. Biophysical J 90:L42–L44.
  • Kumar S, Harrison N, Richards-Kortum R, Sokolov K. 2007. Plasmonic nanosensors for imaging intracellular biomarkers in live cells. Nano Lett 7:1338–1343.
  • Lévy R, Thanh NTK, Doty RC, Hussain I, Nichols RJ, Schiffrin DJ, Brust M, Fernig DG. 2004. Rational and combinatorial design of peptide capping ligands for gold nanoparticles. J Am Chem Soc 126:10076–10084.
  • Lewinski N, Colvin V, Drezek R. 2008. Cytotoxicity of nanoparticles. Small 4:26–49.
  • Liang M, Lin I-C, Whittaker MR, Minchin RF, Monteiro MJ, Toth I. 2010. Cellular uptake of densely packed polymer coatings on gold nanoparticles. ACS Nano 4:403–413.
  • Loo C, Lowery A, Halas N, West J, Drezek R. 2005. Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett 5:709–711.
  • Lukacs GL, Haggie P, Seksek O, Lechardeur D, Freedman N, Verkman AS. 2000. Size-dependent DNA mobility in cytoplasm and nucleus. J Biol Chem 275:1625–1629.
  • Lynch I. 2007. Are there generic mechanisms governing interactions between nanoparticles and cells? Epitope mapping the outer layer of the protein-material interface. Phys A 373:511–520.
  • Mohamed MB, Ismail KZ, Link S, El-Sayed MA. 1998. Thermal reshaping of gold nanorods in micelles. J Phys Chem B 102:9370–9374.
  • Mukherjee S, Ghosh RN, Maxfield FR. 1997. Endocytosis. Physiol Rev 77:759–803.
  • Murray CB, Kagan CR, Bawendi MG. 2000. Synthesis and characterization of monodisperse nanocrystal assemblies. Annu Rev Mater Sci 30:545–610.
  • Nakai T, Kanamori T, Sando S, Aoyama Y. 2003. Remarkably size-regulated cell invasion by artificial viruses. Saccharide-dependent self-aggregation of glycoviruses and its consequences in glycoviral gene delivery. J Am Chem Soc 125:8465–8475.
  • Nativo P, Prior IA, Brust M. 2008. Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano 2:1639–1644.
  • Osaki F, Kanamori T, Sando S, Aoyama Y. 2004. A quantum dot conjugated sugar ball and its cellular uptake on the size effects of endocytosis in the subviral region. J Am Chem Soc 126:6520–6521.
  • Oyelere AK, Chen PC, Huang X, El-Sayed IH, El-Sayed MA. 2007. Peptide-conjugated gold nanorods for nuclear targeting. Bioconjug Chem 18:1490–1497.
  • Paciotti GF, Myer L, Weinreich D, Goia D, Pavel N, McLaughlin RE, Tamarkin L. 2010. Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery. Drug Deliv 11:169–183.
  • Panyam J, Zhou WZ, Prabha S, Sahoo SK, Labhasetwar V. 2002. Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery. FASEB J 16:1217–1226.
  • Perrault SD, Walkey C, Jennings T, Fischer HC, Chan WCW. 2009. Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett 9:1909–1915.
  • Qian X, Peng X-H, Ansari DO, Yin-Goen Q, Chen GZ, Shin DM, Yang L, Young AN, Wang MD, Nie S. 2008. In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat Biotechnol 26:83–90.
  • Rao J. 2008. Shedding light on tumors using nanoparticles. ACS Nano 2:1984–1986.
  • Rayavarapu RJ, Petersen W, Ungureanu C, Post JN, Leeuwen TGV, Manohar S. 2007. Synthesis and bioconjugation of gold nanoparticles as potential probes for light-based imaging techniques. Int J Biomed Imag 2007:1–10.
  • Sandhu KK, McIntosh CM, Simard JM, Smith SW, Rotello VM. 2002. Gold nanoparticle-mediated transfection of mammalian cells. Bioconjugate Chem 13:3–6.
  • Schmid SL, Carter LL. 1990. ATP Is required for receptor-mediated endocytosis in intact cells. J Cell Biol 111:2307–2318.
  • Sée L, Free P, Cesbron Y, Nativo P, Shaheen U, Rigden DJ, Spiller DJ, Fernig DJ, White MRH, Prior IA, Brust M, Lounis B, Lévy R. 2009. Cathepsin L digestion of nanobioconjugates upon endocytosis. ACS Nano 3:2461–1468.
  • Shi W, Wang J, Fan X, Gao H. 2008. Size and shape effects on diffusion and absorption of colloidal particles near a partially absorbing sphere: implications for uptake of nanoparticles in animal cells. Phy Rev E 78:061914–061925.
  • Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M. 2005. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 21:10644–10654.
  • Silverstein SC, Steinman RM, Cohn ZA. 1977. Endocytosis. Annu Rev Biochem 46:669–772.
  • Skirtach AG, Dejugnat C, Braun D, Susha AS, Rogach AL, Parak WJ, Möhwald H, Sukhorukov GB. 2005. The role of metal nanoparticles in remote release of encapsulated materials. Nano Lett 5:1371–1377.
  • Skirtach AG, Javier AM, Kreft O, Köhler K, Alberola AP, Möhwald H, Parak WJ, Sukhorukov GB. 2006. Laser-induced release of encapsulated materials inside living cells. Angew Chem Int Ed 45:4612–4617.
  • Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, Richards-Kortum R. 2003. Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Res 63:1999–2004.
  • Souza GR, Christianson DR, Staquicini FI, Ozawa MG, Snyder EY, Sidman RL, Miller JH, Arap W, Pasqualini R. 2006. Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. Proc Natl Acad Sci USA 103:1215–1220.
  • Suh J, Dawson M, Hanes J. 2005. Real-time multiple-particle tracking: applications to drug and gene delivery. Adv Drug Deliv Rev 57:63–78.
  • Suh J, Wirtz D, Hanes J. 2003. Efficient active transport of gene nanocarriers to the cell nucleus. Proc Natl Acad Sci USA 100:3878–3882.
  • Suh J, Wirtz D, Hanes J. 2004. Real-time intracellular transport of gene nanocarriers studied by multiple particle tracking. Biotechnol Prog 20:598–602.
  • Suk JS, Suh J, Lai SK, Hanes J. 2007. Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons. Exp Biol Med 232:461–469.
  • Sung-Hee P, Seong-Geun O, Ji-Young M, Sung-Sik H. 2006. Loading of gold nanoparticles inside the DPPC bilayers of liposome and their effects on membrane fluidities. Colloids Surf B 48:112–118.
  • Taylor U, Klein S, Petersen S, Kues W, Barcikowski S, Rath D. 2010. Nonendosomal cellular uptake of ligand-free, positively charged gold nanoparticles. Cytometry A 77A:439–446.
  • Tkachenko A, Xie H, Liu Y, Coleman D, Ryan J, Glomm WR, Shipton MK, Franzen S, Feldheim DL. 2004. Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localization signals and peptide transduction domains. Bioconjugate Chem 15:482–490.
  • Tkachenko AG, Xie H, Coleman D, Glomm W, Ryan J, Anderson MF, Franzen S, Feldheim DL. 2003. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting. J Am Chem Soc 125:4700–4701.
  • Turkevich J, Hillier J, Stevenson PC. 1951. A study of the nucleation and growth processes in the synthesis of colloidal gold. Discuss Faraday Soc 11:55–75.
  • Vertegel AS, Siegel RW, Dordick JS. 2004. Silica nanoparticle size influences the structure and enzymatic activity of adsorbed lysozyme. Langmuir 20:6800–6807.
  • Volodkin DV, Skirtach AG, Mohwald H. 2009. Near-IR remote release from assemblies of lipososmes and nanoparticles. Angew Chem Int Ed 121:1839–1841.
  • Wijaya A, Schaffer SB, Pallares IG, Hamad-Schifferli K. 2009. Selective release of multiple DNA oligonucleotides from gold nanorods. ACS Nano 3:80–86.
  • Wilhelm C, Lavialle F, Péchoux C, Tatischef I, Gazeau F. 2008. Intracellular trafficking of magnetic nanoparticles to design multifunctional biovesicles. Small 4:577–582.
  • Xu X-HN, Brownlow WJ, Kyriacou SV, Wan Q, Viola JJ. 2004. Real-time probing of membrane transport in living microbial cells using single nanoparticle optics and living cell imaging. Biochem 43:10400–10413.
  • Yang Z, Leon J, Martin M, Harder JW, Zhang R, Liang D, Lu W, Tian M, Gelovani JG, Qiao A, Li C. 2009. Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles. Nanotechnology 20:165101.
  • Zhang Q, Iwakuma N, Sharma P, Moudgil BM, Wu C, McNeill J, Jiang H, Grobmyer SR. 2009a. Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography Nanotechnology 20:395102.
  • Zhang S, Li J, Lykotrafitis G, Bao G, Suresh S. 2009b. Size-dependent endocytosis of nanoparticles. Adv Mater 21:419–424.
  • Zheng Y, Sanche L. 2009. Gold nanoparticles enhance DNA damage induced by anticancer drugs and radiation. Radiat Res 172:114–119.

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