Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery

References

• Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. 2004a. Enhancement of topical delivery from biodegradable nanoparticles. Pharm Res 21:1818–1825.
   PubMed Web of Science ®Google Scholar
• Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. 2004b. Skin penetration and distribution of polymeric nanoparticles. J Control Release 99:53–62.
   PubMed Web of Science ®Google Scholar
• Barbosa-Barros L, Barba C, Rodríguez G, Cócera M, Coderch L, López-Iglesias C, de la Maza A, López O. 2009. Lipid nanostructures: Self-assembly and effect on skin properties. Mol Pharm 6:1237–1245.
   PubMedGoogle Scholar
• Baroli B, Ennas MG, Loffredo F, Isola M, Pinna R, López-Quintela MA. 2007. Penetration of metallic nanoparticles in human full-thickness skin. J Invest Dermatol 127:1701–1712.
   PubMed Web of Science ®Google Scholar
• Bos JD, Meinardi MMHM. 2000. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol 9:165–169.
   PubMed Web of Science ®Google Scholar
• Bouwstra JA, Honeywell-Nguyen PL, Gooris GS, Ponec M. 2003. Structure of the skin barrier and its modulation by vesicular formulations. Prog Lipid Res 42:1–36.
   PubMed Web of Science ®Google Scholar
• Carrer DC, Vermehren C, Bagatolli LA. 2008. Pig skin structure and transdermal delivery of liposomes: A two photon microscopy study. J Control Release 132:12–20.
   PubMed Web of Science ®Google Scholar
• Cevc G, Blume G, Schatzlein A, Gebauer D, Paul A. 1996. The skin: A pathway for systemic treatment with patches and lipid-based agent carriers. Adv Drug Deliv Rev 18:349–378.
   Web of Science ®Google Scholar
• Cevc G. 2004. Lipid vesicles and other colloids as drug carriers on the skin. Adv Drug Deliv Rev 56:675–711.
   PubMed Web of Science ®Google Scholar
• Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P. 2007. Human skin penetration of sunscreen nanoparticles: In-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol 20:148–154.
   PubMed Web of Science ®Google Scholar
• de Leeuw J, de Vijlder HC, Bjerring P, Neumann HA. 2009. Liposomes in dermatology today. J Eur Acad Dermatol Venereol 23:505–516.
   PubMed Web of Science ®Google Scholar
• Derossi D, Joliot AH, Chassaing G, Prochiantz A. 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem 269:10444–10450.
   PubMed Web of Science ®Google Scholar
• El Maghraby GM, Barry BW, Williams AC. 2008. Liposomes and skin: From drug delivery to model membranes. Eur J Pharm Sci 34:203–222.
   PubMed Web of Science ®Google Scholar
• El Maghraby GM, Williams AC, Barry BW. 2001. Skin hydration and possible shunt route penetration in controlled estradiol delivery from ultradeformable and standard liposomes. J Pharm Pharmacol 53:1311–1322.
   PubMed Web of Science ®Google Scholar
• Elliott E, O'Hare P. 1997. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88:223–233.
   PubMed Web of Science ®Google Scholar
• Elsayed MM, Abdallah OY, Naggar VF, Khalafallah NM. 2007. Lipid vesicles for skin delivery of drugs: Reviewing three decades of research. Int J Pharm 332:1–16.
   PubMed Web of Science ®Google Scholar
• Eum WS, Jang SH, Kim DW, Choi HS, Choi SH, Kim SY, An JJ, Lee SH, Han K, Kang JH, Kang TC, Won MH, Cho YJ, Choi JH, Kim TY, Park J, Choi SY. 2005. Enhanced transduction of Cu,Zn-superoxide dismutase with HIV-1 Tat protein transduction domains at both termini. Mol Cells 19:191–197.
   PubMed Web of Science ®Google Scholar
• Futaki S. 2002. Arginine-rich peptides: Potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms. Int J Pharm 245:1–7.
   PubMed Web of Science ®Google Scholar
• Gamer AO, Leibold E, van Ravenzwaay B. 2006. The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. Toxicol In Vitro 20:301–307.
   PubMed Web of Science ®Google Scholar
• Hadgraft J. 2001. Modulation of the barrier function of the skin. Skin Pharmacol Appl Skin Physiol 14:72–81.
   PubMedGoogle Scholar
• Ho A, Schwarze SR, Mermelstein SJ, Waksman G, Dowdy SF. 2001. Synthetic protein transduction domains: Enhanced transduction potential in vitro and in vivo. Cancer Res 61:474–477.
   PubMed Web of Science ®Google Scholar
• Honeywell-Nguyen PL, Bouwstra JA. 2005. Vesicles as a tool for transdermal and dermal delivery. Drug Disc Today: Technol 2:67–74.
   PubMedGoogle Scholar
• Honeywell-Nguyen PL, de Graaff AM, Groenink HW, Bouwstra JA. 2002. The in vivo and in vitro interactions of elastic and rigid vesicles with human skin. Biochim Biophys Acta 1573:130–140.
   PubMed Web of Science ®Google Scholar
• Honeywell-Nguyen PL, Gooris GS, Bouwstra JA. 2004. Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo. J Invest Dermatol 123:902–910.
   PubMed Web of Science ®Google Scholar
• Honeywell-Nguyen PL, Wouter Groenink HW, de Graaff AM, Bouwstra JA. 2003. The in vivo transport of elastic vesicles into human skin: Effects of occlusion, volume and duration of application. J Control Release 90:243–255.
   PubMed Web of Science ®Google Scholar
• Hou YW, Chan MH, Hsu HR, Liu BR, Chen CP, Chen HH, Lee HJ. 2007. Transdermal delivery of proteins mediated by non-covalently associated arginine-rich intracellular delivery peptides. Exp Dermatol 16:999–1006.
   PubMed Web of Science ®Google Scholar
• Huang SS, Sung SH, Chiang CE. 2007. Chitosan potentiation of warfarin effect. Ann Pharmacother 41:1912–1914.
   PubMedGoogle Scholar
• Jin LH, Bahn JH, Eum WS, Kwon HY, Jang SH, Han KH, Kang TC, Won MH, Kang JH, Cho SW, Park J, Choi SY. 2001. Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and arginine-rich peptides into mammalian cells. Free Radic Biol Med 31:1509–1519.
   PubMed Web of Science ®Google Scholar
• Jung S, Otberg N, Thiede G, Richter H, SterryW, Panzner S, Lademann J. 2006. Innovative liposomes as a transfollicular drug delivery system: Penetration into porcine hair follicles. J Invest Dermatol 126:1728–1732.
   PubMed Web of Science ®Google Scholar
• Kang MJ, Eum JY, Jeong MS, Choi SE, Park SH, Cho HI, Cho CS, Seo SJ, Lee MW, Choi YW. 2010. Facilitated skin permeation of oregonin by elastic liposomal formulations and suppression of atopic dermatitis in NC/Nga mice. Biol Pharm Bull 33:100–106.
   PubMed Web of Science ®Google Scholar
• Kanikkannan N, Kandimalla K, Lamba SS, Singh M. 2000. Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery. Curr Med Chem 7:593–608.
   PubMed Web of Science ®Google Scholar
• Kim DW, Eum WS, Jang SH, Yoon CS, Choi HS, Choi SH, Kim YH, Kim SY, Lee ES, Baek NI, Kwon HY, Choi JH, Choi YC, Kwon OS, Cho SW, Han K, Lee KS, Park J, Choi SY. 2003. Ginsenosides enhance the transduction of tat-superoxide dismutase into mammalian cells and skin. Mol Cells 16:402–406.
   PubMed Web of Science ®Google Scholar
• Kirjavainen M, Urtti A, Jaaskelainen I, SuhonenTM, Paronen P, Valjakka-Koskela R, Kiesvaara J, Monkkonen J. 1996. Interaction of liposomes with human skin in vitro – the influence of lipid composition and structure. Biochim Biophys Acta 1304:179–189.
   PubMed Web of Science ®Google Scholar
• Kong M, Chen XG, Liu CS, Liu CG, Meng XH, Yu le J. 2008. Antibacterial mechanism of chitosan microspheres in a solid dispersing system against E. coli. Colloids Surf B Biointerfaces 65:197–202.
   PubMed Web of Science ®Google Scholar
• Küchler S, Herrmann W, Panek-Minkin G, Blaschke T, Zoschke C, Kramer KD, Bittl R, Schäfer-Korting M. 2010. SLN for topical application in skin diseases. Characterization of drug-carrier and carrier-target interactions. Int J Pharm (in press), PMID: 20153414.
   PubMedGoogle Scholar
• Küchler S, Radowski MR, Blaschke T, Dathe M, Plendl J, Haag R, Schäfer-Korting M, Kramer KD. 2009. Nanoparticles for skin penetration enhancement – a comparison of a dendritic core-multishell-nanotransporter and solid lipid nanoparticles. Eur J Pharm Biopharm 71:243–250.
   PubMed Web of Science ®Google Scholar
• Kumar R, Philip A. 2007. Modified transdermal technologies: Breaking the barriers of drug permeation via the skin. Trop J Pharm Res 6:633–644.
   Web of Science ®Google Scholar
• Lademann J, Knorr F, Richter H, Blume-Peytavi U, Vogt A, Antoniou C, Sterry W, Patzelt A. 2008. Hair follicles – an efficient storage and penetration pathway for topically applied substances. Skin Pharmacol Physiol 21:150–155.
   PubMed Web of Science ®Google Scholar
• Lademann J, Otberg N, Richter H, Weigmann H-J, Lindemann U, Schaefer H. 2001. Investigation of follicular penetration of topically applied substances. Skin Pharmacol Appl Skin Physiol 14:17–22.
   PubMedGoogle Scholar
• Lademann J, Richter H, Teichmann A, Otberg N, Blume-Peytavi U, Luengo J, Weiss B, Schaefer UF, Lehr CM, Wepf R, Sterry W. 2007. Nanoparticles – an efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm 66:159–164.
   PubMed Web of Science ®Google Scholar
• Lademann J, Weigmann H, Rickmeyer C, Barthelmes H, Schaefer H, Mueller G, Sterry W. 1999. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol Appl Skin Physiol 12:247–256.
   PubMedGoogle Scholar
• Lim JM, Chang MY, Park SG, Kang NG, Song YS, Lee YH, Yoo YC, Cho WG, Choi SY, Kang SH. 2003. Penetration enhancement in mouse skin and lipolysis in adipocytes by TAT-GKH, a new cosmetic ingredient. J Cosmet Sci 54:483–491.
   PubMedGoogle Scholar
• Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J. 1995. Inhibition of nuclear translocation of transcription factor NFkB by a synthetic peptide containing a cell membranepermeable motif and nuclear localization sequence. J Biol Chem 270:14255–14258.
   PubMed Web of Science ®Google Scholar
• Lins L, Decaffmeyer M, Thomas A, Brasseur R. 2008. Relationships between the orientation and the structural properties of peptides and their membrane interactions. Biochim Biophys Acta 1778:1537–1544.
   Google Scholar
• Lombardi Borgia S, Regehly M, Sivaramakrishnan R, Mehnert W, Korting HC, Danker K, Röder B, Kramer KD, Schäfer-Korting M. 2005. Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J Control Release 110:151–163.
   PubMed Web of Science ®Google Scholar
• Lopes LB, Brophy CM, Furnish E, Flynn CR, Sparks O, Komalavilas P, Joshi L, Panitch A, Bentley MV. 2005. Comparative study of the skin penetration of protein transduction domains and a conjugated peptide. Pharm Res 22:750–757.
   PubMed Web of Science ®Google Scholar
• Lopes LB, Furnish E, Komalavilas P, Seal BL, Panitch A, Bentley MV, Brophy CM. 2008. Enhanced skin penetration of P20 phosphopeptide using protein transduction domains. Eur J Pharm Biopharm 68:441–445.
   PubMed Web of Science ®Google Scholar
• Lucks JS, Müller RH. 1991. Medication vesicles made of solid lipid particles (solid lipid Nanospheres SLN). EP0000605497.
   Google Scholar
• Luengo J, Weiss B, Schneider M, Ehlers A, Stracke F, König K, Kostka KH, Lehr CM, Schaefer UF. 2006. Influence of nanoencapsulation on human skin transport of flufenamic acid. Skin Pharmacol Physiol 19:190–197.
   PubMed Web of Science ®Google Scholar
• Mehnert W, Mäder K. 2001. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev 47:165–196.
   PubMed Web of Science ®Google Scholar
• Mezei M, Gulasekharam V. 1980. Liposomes – a selective drug delivery system for the topical route of administration. Lotion dosage form. Life Sci 26:1473–1477.
   PubMed Web of Science ®Google Scholar
• Mezei M, Gulasekharam V. 1982. Liposomes – a selective drug delivery system for the topical route of administration: Gel dosage form. J Pharm Pharmacol 34:473–474.
   PubMed Web of Science ®Google Scholar
• Mitchell DJ, Kim DT, Steinman L, Fathman CG, Rothbard JB. 2000. Polyarginine enters cells more efficiently than other polycationic homopolymers. J Pept Res 56:318–325.
   PubMedGoogle Scholar
• Mortensen LJ, Oberdörster G, Pentland AP, Delouise LA. 2008. In vivo skin penetration of quantum dot nanoparticles in the murine model: The effect of UVR. Nano Lett 8:2779–2787.
   PubMed Web of Science ®Google Scholar
• Naik A, Kalia Y, Guy R. 2000. Transdermal drug delivery: Overcoming the skin's barrier function. Pharm Sci Technolo Today 3:318–326.
   PubMedGoogle Scholar
• Otberg N, Patzelt A, Rasulev U, Hagemeister T, Linscheid M, Sinkgraven R, Sterry W, Lademann J. 2008. The role of hair follicles in the percutaneous absorption of caffeine. Br J Clin Pharmacol 65:488–492.
   PubMed Web of Science ®Google Scholar
• Panos I, Acosta N, Heras A. 2008. New drug delivery systems based on chitosan. Curr Drug Discov Technol 5:333–341.
   PubMedGoogle Scholar
• Park J, Ryu J, Jin LH, Bahn JH, Kim JA, Yoon CS, Kim DW, Han KH, Eum WS, Kwon HY, Kang TC, Won MH, Kang JH, Cho SW, Choi SY. 2002. 9-polylysine protein transduction domain: Enhanced penetration efficiency of superoxide dismutase into mammalian cells and skin. Mol Cells 13:202–208.
   PubMed Web of Science ®Google Scholar
• Patel LN, Zaro JL, Shen WC. 2007. Cell penetrating peptides: Intracellular pathways and pharmaceutical perspectives. Pharm Res 24:1977–1992.
   PubMed Web of Science ®Google Scholar
• Patlolla RR, Chougule M, Patel AR, Jackson T, Tata PN, Singh M. 2010a. Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release 144:233–241.
   PubMed Web of Science ®Google Scholar
• Patlolla RR, Desai P, Belay K, Singh M. 2010b. Translocation of cell penetrating peptide engrafted nanoparticles across skin layers. Biomaterials 31:5598–5607.
   PubMed Web of Science ®Google Scholar
• Rancan F, Papakostas D, Hadam S, Hackbarth S, Delair T, Primard C, Verrier B, Sterry W, Blume-Peytavi U, Vogt A. 2009. Investigation of polylactic acid (PLA) nanoparticles as drug delivery systems for local dermatotherapy. Pharm Res 26:2027–2036.
   PubMed Web of Science ®Google Scholar
• Rossi S, Marciello M, Sandri G, Ferrari F, Bonferoni MC, Papetti A, Caramella C, Dacarro C, Grisoli P. 2007. Wound dressings based on chitosans and hyaluronic acid for the release of chlorhexidine diacetate in skin ulcer therapy. Pharm Dev Technol 12:415–422.
   PubMed Web of Science ®Google Scholar
• Rothbard JB, Garlington S, Lin Q, Kirschberg T, Kreider E, McGrane PL, Wender PA, Khavari PA. 2000. Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation. Nat Med 6:1253–1257.
   PubMed Web of Science ®Google Scholar
• Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. 2006. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicol Sci 91:159–165.
   PubMed Web of Science ®Google Scholar
• Schäfer-Korting M, Mehnert W, Korting HC. 2007. Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv Drug Deliv Rev 59:427–443.
   PubMed Web of Science ®Google Scholar
• Schramlová J, Blazek K, Bartácková M, Otová B, Mardesicová L, Zizkovský V, Hulínská D. 1997. Electron microscopic demonstration of the penetration of liposomes through skin. Folia Biol (Praha) 43:165–169.
   PubMed Web of Science ®Google Scholar
• Schutze-Redelmeier MP, Kong S, Bally MB, Dutz JP. 2004. Antennapedia transduction sequence promotes anti tumour immunity to epicutaneously administered CTL epitopes. Vaccine 22:1985–1991.
   PubMed Web of Science ®Google Scholar
• Shanmugam S, Song CK, Nagayya-Sriraman S, Baskaran R, Yong CS, Choi HG, Kim DD, Woo JS, Yoo BK. 2009. Physicochemical characterization and skin permeation of liposome formulations containing clindamycin phosphate. Arch Pharm Res 32:1067–1075.
   PubMed Web of Science ®Google Scholar
• Souto EB, Müller RH. 2008. Cosmetic features and applications of lipid nanoparticles (SLN, NLC). Int J Cosmet Sci 30:157–165.
   PubMedGoogle Scholar
• Stracke F, Weiss B, Lehr CM, König K, Schaefer UF, Schneider M. 2006. Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs. J Invest Dermatol 126:2224–2233.
   PubMed Web of Science ®Google Scholar
• Szikszai Z, Kertész Zs, Bodnár E, Major I, Borbíró I, Kiss AZ, Hunyadi J. 2010. Nuclear microprobe investigation of the penetration of ultrafine zinc oxide into intact and tape-stripped human skin. Nuclr Instru and Meth B 268:2160–2163.
   Google Scholar
• Teeranachaideekul V, Boonme P, Souto EB, Müller RH, Junyaprasert VB. 2008. Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC. J Control Release 128:134–141.
   PubMed Web of Science ®Google Scholar
• Teo LA, Shearwood C, Chye Ng K, Lu J, Moochhala S. 2006. Transdermal microneedles for drug delivery applications. Mater Sci Eng: B 132:151–154.
   Web of Science ®Google Scholar
• Tokudome Y, Saito Y, Sato F, Kikuchi M, Hinokitani T, Goto K. 2009. Preparation and characterization of ceramide-based liposomes with high fusion activity and high membrane fluidity. Colloids Surf B Biointerfaces 73:92–96.
   PubMed Web of Science ®Google Scholar
• Toll R, Jacobi U, Richter H, Lademann J, Schaefer H, Blume-Peytavi U. 2004. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J Invest Dermatol 123:168–176.
   PubMed Web of Science ®Google Scholar
• Torchilin VP. 2008. Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Biopolymers 90:604–610.
   PubMed Web of Science ®Google Scholar
• Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. 2000. Ethosomes – novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties. J Control Release 65:403–418.
   PubMed Web of Science ®Google Scholar
• Verma DD, Verma S, Blume G, Fahr A. 2003. Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: A skin penetration and confocal laser scanning microscopy study. Eur J Pharm Biopharm 55:271–277.
   PubMed Web of Science ®Google Scholar
• Vives E, Brodin P, Lebleu B. 1997. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 272:16010–16017.
   PubMed Web of Science ®Google Scholar
• Vogt A, Combadiere B, Hadam S, Stieler KM, Lademann J, Schaefer H, Autran B, Sterry W, Blume-Peytavi U. 2006. 40 nm, but not 750 or 1500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin. J Invest Dermatol 126:1316–1322.
   PubMed Web of Science ®Google Scholar
• Weller K, Lauber S, Lerch M, Renaud A, Merkle HP and Zerbe O. 2005. Biophysical and biological studies of end-group-modified derivatives of Pep-1. Biochemistry 44:15799–15811.
   PubMed Web of Science ®Google Scholar
• Wender PA, Rothbard IB, Jessop TC, Kreider EL, Wylie BL. 2002. Oligocarbamate molecular transporters: Design, synthesis, and biological evaluation of a new class of transporters for drug delivery. J Am Chem Soc 124:13382–13383.
   PubMed Web of Science ®Google Scholar
• Wissing SA, Müller RH. 2003. Cosmetic applications for solid lipid nanoparticles (SLN). Int J Pharm 254:65–68.
   PubMed Web of Science ®Google Scholar
• Zhang LW, Monteiro-Riviere NA. 2008. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacol Physiol 21:166–180.
   PubMed Web of Science ®Google Scholar
• Zhang LW, Yu WW, Colvin VL, Monteiro-Riviere NA. 2008. Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicol Appl Pharmacol 228:200–211.
   PubMed Web of Science ®Google Scholar