25
Views
28
CrossRef citations to date
0
Altmetric
Review Article

Protein Kinases in Neutrophils: A Review

Pages 61-79 | Published online: 09 Jul 2009

References

  • Ando S., Tanabe K., Gonda Y., Sato C., Inagaki M. Domain-and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure. Biochemistry 1989; 28: 2974–2979
  • Babior B. M. Protein phosphorylation and the respiratory burst. Arch. Biochem. Biophys. 1988; 264: 361–367
  • Bass D. A., Gerard C., Olbrantz P., Wilson J., McCall C. E., McPhail L. C. Priming of the respiratory burst of neutrophil by diacylglycerol: Independence from activation or translocation of PK-C. J. Biol. Chem. 1987; 262: 6643–6649
  • Bauldry S. A., Wykle B. L., Bass D. A. 1988. Phospholipase A2 activation in human neutrophils. Differential actions of diacylglycerols and alkyacylglycerols in priming cells for stimulation by N-formyl-Met-Leu-Phe 1988; J. Biol. Chem.: 16787–16795
  • Becker E. L., Kermode J. C., Naccache P. H., Yassin R., Munoz J. J., Marsh M. L., Huang C. K., Sha'afi R. I. Pertussis toxin as a probe of neutrophil activation. Fed. Proc. 1986; 45: 2151–2155
  • Becker E. L., David A. T., Estensen P. D., Quie P. G. Cytochalasin B IV. Inhibition and stimulation of chemotaxis of rabbit and human polymorphonuclear leukocytes. J. Immunol. 1972; 108: 396–402
  • Berkow R. L., Dodson R. W., Kraft A. S. The effect of H-7 on human neutrophil oxidative burst and degranulation. J. Leukocyte Biol. 1987; 41: 441–446
  • Billah M. M., Pai J-K., Mullman T. M., Egan R. W., Siegel M. I. Regulation of phospholipase D in HL-60 granulocytes. J. Biol. Chem. 1989; 204: 9069–9076
  • Bishop W. R., Bell R. M. Functions of diacylglycerol in glycerolipid metabolism, signal transduction and cellular transformation. Oncogene Res. 1988; 2: 205–218
  • Blackburn W., Wallace R. The bioflavoroid quercetin inhibits neutrophil de-granulation superoxide production and the phosphorylation of specific neutrophil proteins. Biochem. Biophys. Rs. Commun. 1987; 144: 1229–1236
  • Boyer P. D., Krebs E. G. The Enzymes, Vol. 17. Academic, Orlando, FL 1986
  • Buday L., Seprodi J., Farkas G., Meszaros G., Romkanyi T., Banhegyi G., Mandl J., Antoni F., Farago A. Proteolytic activation of protein kinase C in the extracts of cells treated for a short time with phorbol ester. FEBS Lett. 1987; 223: 15–19
  • Caldwell S. E., Bass D. A., Mc Phail L. C., Mc Call C. E. 1987. Phosphorylation of a 48 kD protein, defective in chronic granulomatous disease of neutrophils, is not required for activation of the respiratory burst 1987; Fed. Proc.: 1030, (abstract).
  • Chafouleas J. G., Dedman T. R., Munjaal R. P., Means A. R. 1979. Calmodulin. Development and application of a sensitive radioimmunoassay 1979; J. Biol. Chem.: 10262–10267
  • Christiansen N. O., Juhl H. Purification and properties of PK-C from bovine PMN. Biochim. Biophys. Acta 1986; 885: 170–176
  • Chijiwa T., Hagiwara M., Hidaka H. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide and affinity purification of casein kinase I from bovine testis. J. Biol. Chem. 1989; 264: 4924–4927
  • Cockcroft S., Barrowman M. M., Gomperts B. D. Breakdown and synthesis of polyphosphoinositides in fMet-Leu-Phe stimulated neutrophils. FEBS 1985; 181: 259–262
  • Conn P. J., Strong J. A., Azhedrian E. M., Nairn A. C., Greengard P., Kaczmarek L. K. Protein kinase inhibitors selectively block phorbol ester or forskolin-induced changes in excitability of Aplysia neurons. J. Neurosci. 1989; 9: 473–479
  • Connoly T. M., Lawing W. J., Majerus P. W. Protein kinase C phosphorylates human platelet inositol triphosphate 5′-monoesterase, increasing the phosphatase activity. Cell 1986; 46: 951–958
  • Czech M. P., Klarlund J. K., Yagaloff K. A., Bradford A. P., Lewis R. E. 1988. Insulin receptor signaling 1988; J. Biol. Chem.: 11017–11020
  • Deli E., Kiss Z., Wilson E., Lambeth J. D., Kuo J. F. Immunocytochemical localization of protein kinase C in resting and activated human neutrophils. FEBS Lett. 1987; 221: 365–369
  • Devereotes P. N., Zigmond S. H. Chemotaxis in eukaryotic cells: A focus on leukocytes and dictyostelium. Annu. Rev. Cell Biol. 1988; 4: 649–686
  • Dewald B., Thelen M., Baggiolini M. 1988. Two transduction sequences are necessary for neutrophil activation by receptor agonist 1988; J. Biol. Chem.: 16179–16184
  • Dianoux A., Stasia M., Vignais P. V. Purification and characterization of an isoform of protein kinase C from bovine neutrophils. Biochemistry 1989; 28: 424–431
  • Dillon S. B., Verghese M. W., Snyderman R. Signal transduction in cells following binding of chemoattractants to membrane receptors. Virchows Arch. B Cell Pathol. 1988; 55: 65–80
  • DiVirgilio F., Lew D. P., Pozzan T. Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels. Nature 1984; 310: 691–693
  • Dougherty R. W., Niedel J. E. Cytosolic calcium regulates phorbol-12-myristate-13-acetate binding affinity in intact phagocytes. J. Biol. Chem. 1986; 261: 4097–4100
  • Dusenberg K. G., Mendiola J. R., Skubitz K. M. Evidence for ecto-protein kinase activity on the surface of human neutrophils. Biochem. Biophys Res. Commun. 1988; 153: 7–13
  • Edelman A. M., Blumenthal D. K., Krebs E. G. Protein serine/threonine kinase. Annu. Rev. Biochem. 1987; 56: 567–613
  • Fechheimer M., Zigmond S. H. Changes in cytoskeletal proteins of polymor-phonuclear leukocytes induced by chemotactic peptides. Cell Motility 1983; 3: 349–361
  • Fujiki T., Philips W. A., Johnston R. B., Korchak H. M. 1988. Phorbol ester and calcium elicit selective translocation of the isotype of protein kinase C in human neutrophil cytoplasts 1988; J. Cell Biol.: 57a
  • Gallin J. I., Goldstein I. M., Snyderman R. Inflammation: Basic Principles and Clinical Correlates. Raven Press, New York 1988
  • Garcia R. C., Segal A. W. Phosphorylation of the subunits of cytochrome b-245 upon triggering of the respiratory burst of human neutrophils and macrophages. Biochem. J. 1988; 252: 901–904
  • Gee C. E., Griffin J., Sastre L., Miller L. J., Springer T. A., Piwnica-Worms H., Roberts T. M. Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. Proc. Natl. Acad. Sci. 1986; 83: 5131–5135
  • Gennaro R., Scaggiante B., Romeo D. Clinical Immunology: Human Inflammatory Disease, Vol. 1, G. M. Masone. Decker, Toronto 1987; 273–294
  • Gomez-Cambronero J., Yamaze M., Metwally F., Molski T. F. P., Bonak V. A., Huang C-K., Becker E. L., Sha'afi R. I. Granulocyte macrophage colony stimulating factor and human neotrophils: Role of guanine nucleotide regulatory protein. Proc. Natl. Acad. Sci. USA 1989; 86: 3569–3573
  • Grandori C., Hanafusa H. p60c-arc is complexed with a cellular protein in sub-cellular compartments involved in exocytosis. J. Cell Biol. 1988; 107: 2125–2135
  • Grinstein S., Furuya W. Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca and protein kinase C-independent signaling pathway. J. Biol. Chem. 1988; 263: 1779–1783
  • Hanks A. K., Quinn A. M., Hunter T. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science 1988; 241: 42–51
  • Harvath L., McCall C. E., Bass D. A., Mc Phail L. C. Inhibition of human neutrophil chemotaxis by the protein kinase inhibitor, C-l. J. Immunol. 1987; 139: 3055–3061
  • Hess J. F., Bourret R. B., Simon M. I. Histidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis. Nature 1988; 336: 139–143
  • Hirata F., Notsu Y., Matsuda K., Vasanthakumar G., Schiffmann E., Wong T., Goldberg A. R. Inhibition of leukocyte chemotaxis by glu-glu-glu-glu-tyr-pro-metglu-and leu-ile-glu-asp-asn-glu-tyr-ala-arg-gln-gly. Biochem. Biophys. Res. Commun. 1984; 118: 682–690
  • Honeycutt P. J., Niedel J. E. 1986. Cytochalasin B enhancement of the diacylglycerol response in f-Met-Leu-Phe stimulated neutrophils 1986; J. Biol. Chem.: 15900–15905
  • Hopfield J. F., Tank D. W., Greengard P., Huganir R. L. Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation. Nature 1988; 336: 677–680
  • Horn W., Karnovsky M. Features of the translocation of protein kinase C in neutrophils stimulated with the chemotactic peptide fMet-Leu-Phe. Biochem. Biophys. Res. Commun. 1986; 139: 1169–1175
  • Huang C-K., Mackin W. M., Bormann B. J., Becker E. L. Cyclic-AMP receptor protein and cAMP-dependent protein kinase activity in rabbit peritoneal neutrophils. J. Reticuloendothel. Soc. 1983; 34: 413–421
  • Huang C-K., Hill J. M., Bormann B. J., Mackin W. M., Becker E. L. Endogenous substrates for cAMP-dependent and calcium-dependent protein phosphorylation in rabbit peritoneal neutrophils. Biochim. Biophys. Acta 1983; 760: 126–135
  • Huang C-K., Oshana S. C. Partial characterization of protein kinase C and inhibitor activity of protein kinase C in rabbit peritoneal neutrophils. J. Leukocyte Biol. 1986; 39: 671–678
  • Huang C-K., Devanney J. F., Kanaho Y. Regulation of membrane associated protein kinase C by guanine nucleotide in rabbit peritoneal neutrophils. Biochem. Biophys. Res. Commun. 1987; 142: 242–250
  • Huang C. K., Devanney J. F., Kennedy S. P. Vimentin, a cytoskeletal substrate of protein kinase C. Biochem. Biophys. Res. Commun. 1988; 150: 1006–1011
  • Huang C. K., Laramee G., Casnellie J. E. Chemotactic factor induced tyro-sine phosphorylation of membrane associated proteins in rabbit peritoneal neutrophils. Biochem. Biophys. Res. Commun. 1988; 151: 794–801
  • Huang C. K., Laramee G. 1988. Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophil pretreated with chemotactic factors. Effect of fMet-Leu-Phe and partial characterization of the protein kinase 1988; J. Biol. Chem.: 13144–13151
  • Huang C. K., Bonak V., Laramee G., Casnellie J. G. 1989. Regulation of protein tyrosine phosphorylation in rabbit peritoneal neutrophil 1989; FASEB J.: A962, (abstract).
  • Imamura K., Kafe D. 1988. Colony-stimulating factor-1-induced Na+-influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein 1988; J. Biol. Chem.: 14093–14098
  • Irita K., Takeshige K., Minahami S. Phosphorylation of myosin light chain in intact pig leukocytes stimulated by phorbol-12-myristate-13-acetate. Biochim. Biophys. Acta 1984; 803: 21–28
  • Jack R. M., Fearon D. T. 1989. Selective synthesis of mRNA and proteins by human peripheral blood neutrophils 1989; J. Immunol.: 4286–4293
  • Jefferson A. B., Schulman H. 1988. Sphingosine inhibits calmodulin-dependent enzymes 1988; J. Biol. Chem.: 15241–15244
  • Jesaitis A. J., Tolley J. O., Allen R. A. 1986. Receptor cytoskeleton interaction and membrane traffic may regulate chemoattractant induced superoxide production in human granulocytes 1986; J. Biol. Chem.: 13662–13669
  • Juhl H. Phosphorylation of glycogen synthase I from human polymorphonuclear leukocyte. Mol. Cell Biochem. 1981; 35: 77–92
  • Kamm K. E., Stull J. T. Regulation of smooth muscle contractile elements by second messengers. Annu. Rev. Physiol. 1989; 51: 299–313
  • Kennedy S. P., Sha'afi R. I., Becker E. L. Demonstration of inositol phosphate 5-phosphomonoesterase activity in rabbit neutrophils: Absence of a role for protein kinase C. Biochem. Biophys. Res. Commun. 1988; 155: 189–196
  • Klee C. B. Calcium-dependent phospholipid-(and membrane-) binding proteins. Biochemistry 1988; 27: 6645–6652
  • Koenderman L., Tool A., Roos D. M., Verhoeven A. J. 1,2-Diacylglycerol accumulation in human neutrophils does not correlate with respiratory burst activation. FEBS 1989; 243: 399–403
  • Koenderman L., Yazdanbakhsh M., Roos D., Verhoeven A. L. Dual mechanisms in priming of the chemoattractant-induced respiratory burst in human granulocytes: A Ca+2-dependent and a Ca+2-independent route. J. Immunol. 1989; 142: 623–628
  • Kraft A. S., Berkow R. L. Tyrosine kinase and phosphotyrosine phosphatases activity in human promyelocytic leukemia cells and human polymorphonuclear leukocytes. Blood 1987; 70: 356–362
  • Kramer I. M., van der Bend R. L., Verhoeven A. J., Roos D. The 47-kDa protein involved in the NADPH:O2 oxidoreductase activity of human neutrophils is phosphorylated by cyclic AMP-dependent protein kinase without induction of a respiratory burst. Biochim. Biophys. Acta 1988; 971: 189–196
  • Kramer I. M., van der Bend R. L., Tool A. T. J., van Blitterswicj W. J., Roos D., Verhoeven A. J. l-O-Hexadecyl-2-O-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophil. J. Biol. Chem. 1989; 264: 5876–5884
  • Krupinski J., Rajaram R., Lakonishok M., Benovic J. L., Cerione R. A. 1988. Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles 1988; J. Biol. Chem.: 12333–12341
  • Lambeth J. D., Burnham D. N., Tyagi S. R. Sphinganine effects on chemotactic factor induced diacylglycerol generation, calcium fluxes. O2-generation and cell viability in the human neotrophils. J. Biol. Chem. 1988; 263: 3818–3822
  • Lew P. D., Monod A., Krase K., Waldvogel F. A., Biden T. J., Shlegel W. 1986. The role of cytosolic free calcium in the generation of inositol 1,4,5-triphosphate and inositol 1,3,4-triphosphate in HL-60 cells. Differential effects of chemotactic peptide receptors stimulation at distinct calcium levels 1986; J. Biol. Chem.: 13123–13127
  • Lew P. D., Monod A., Waldvogel F. A., Dewald B., Baggiolini M., Pozan T. Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils. J. Cell Biol. 1986; 102: 2197–2204
  • Lochner J. E., Badwey J. A., Horn W., Karnovsky M. L. All transretinal stimulates O2- and phospholipase C activity in neutrophils without significantly blocking PK-C. Proc. Natl. Acad. Sci. USA 1986; 83: 7673–7677
  • Maher P. A., Pasquale E. B., Wang J. Y. J., Singer S. J. Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proc. Natl. Acad. Sci. USA 1985; 82: 6576–6580
  • Martins T. J., Sugimoto Y., Erikson R. L. Dissociation of inositol triphosphate from diacylglycerol production in Rous-Sarcoma virus-transformed fibroblasts. J. Cell Biol. 1989; 108: 683–691
  • Masaracchia R. A., Mallic S., Murdoch F. E. Regulation of S6 protein kinase from human placenta: Evidence for activation by an activating enzyme and insulin receptor. Insulin Action and Diabetes, Vol. 1, J. Goren. Raven Press, New York 1988; 169–172
  • McIntyre T. M., Reinhold S. L., Precott S. M., Zimmerman G. A. 1987. PK-C activity appears to be required for the synthesis of PAF and LTB4 by human neutrophils 1987; J. Biol. Chem.: 15370–15376
  • Melloni E., Pontremoli S., Michetti M., Sacco O., Sapratore B., Horecker B. L. The involvement of calpain in the activation of protein kinase C in neutrophil stimulated by phorbol myristic acid. J. Biol. Chem. 1986; 261: 1401–1405
  • Mege J. L., Tao W., Molski T. F. P., Gomez-Cambronero J., Huang C. K., Becker E. L., Sha'afi R. I. Diacylglycerol kinase inhibitor R 59022 and stimulated neutrophil responses. Am. J. Physiol. 255 Cell Physiol. 1988; 24: C589–C594
  • Meshulam T., Proto P., Diamond R. D., Melnick D. A. Calcium modulation and chemotactic responses: Divergent stimulation of neutrophil chemotaxis and cytosolic calcium response by the chemotactic peptide receptor. J. Immunol. 1986; 137: 1954–1960
  • Naccache P. H., Molski T. F. P., Sha'afi R. I. Polymyxin B inhibits phorbol-12-myristate-13-acetate but not chemotactic factor induced effects in rabbit neutrophils. FEBS Lett. 1985; 193: 227–230
  • Naccache P. H., Therrien S., Caon A. A., Liao N., Gilbert C., Mc Coll S. R. Chemoattractant-induced cytoplasmic pH changes and cytoskeletal reorganization in human neutrophils. J. Immunol. 1989; 142: 2438–2444
  • Nakano H., Kabayashi E., Takahashi A. L., Tamaoki T., Kuznu Y., Iba H. Staurosporine inhibits tyrosine-specific protein kinase activity of Rous-sarcoma virus transforming protein P60. J. Antibiotics 1987; 5: 706–708
  • Nasmith P. E., Mills G. B., Grinstein S. Guanine nucleotides induce tyrosine phosphorylation and activation of the respiratory burst in neutrophils. Biochem. J. 1989; 257: 893–897
  • Nasmith P. E., Grinstein S. 1987. Are calcium channels in neutrophils activated by a rise in cytosolic free calcium 1987; FEBS Lett.: 95–100
  • Nath J., Powledge A., Wright D. G. Studies of signal transduction in the respiratory burst-associated stimulation of fMet-Leu-Phe-induced tubulin tyrosinolation and phorbol 12-myristate 13-acetate-induced posttranslational incorporation of tyrosine into multiple proteins in activated neutrophils and HL-60 cells. J. Biol. Chem. 1989; 264: 848–856
  • Nishihira J., Mc Phail L. C., O'Flaherty J. T. Stimulus-dependent mobilization of protein kinase C. Biochem. Biophys. Res. Commun. 1983; 134: 587–594
  • Nishihira J., O'Flaherty J. T. Phorbol myristate acetate receptor in human polymorphonuclear neutrophil. J. Immunol. 1985; 135: 3439–3447
  • Nishizuka Y. The molecular heterogeneity of protein-kinase C and its implications for cellular regulation. Nature 1988; 334: 661–665
  • Parker J., Daniel J. W., Waites M. Evidence of Pk-C involved in PMA stimulated arachidonic acid release and prostaglandin E synthesis. J. Biol. Chem. 1987; 262: 5385–5393
  • Parsons T. Non-catalytic domains of cytoplasmic protein-tyrosine kinase: Regulatory elements in signal transduction. Oncogene 1988; 3: 491–495
  • Periani A., Snyderman R. Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium. J. Biol. Chem. 1989; 264: 1005–1009
  • Perlmutter R. M., Marth J. D., Ziegler S. F., Garvin A. M., Pawar S., Cooke M. P., Abraham K. M. Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells. Biochim. Biophys. Acta 1988; 948: 245–262
  • Phan D. T. P., Henry J., Rosenfeld C., Kahn A. Protein kinases in normal human blood. Am. J. Hematol. 1983; 15: 105–115
  • Przwansky K. B., Steiner A. L., Spitzenagel J. K., Kapoor C. O. Compartmentalization of cyclic AMP during phagocytosis by human neutrophilic granulocytes. Science 1981; 211: 407–409
  • Reibman J., Korchak H. M., Vosshall L. B., Haines K. A., Rich A. M., Weissmann G. Changes in diacylglycerol labeling, cell shape and protein phosphorylation: Distinguish “triggering” from “activation” of human neutrophils. J. Biol. Chem. 1988; 263: 6322–6328
  • Remaley A. T., Kahns D. B., Basford R. G., Glew R. H., Kaplan S. S. 1984. Leishomanial phosphatase blocks neutrophil O2- production 1984; J. Biol. Chem.: 11–173
  • Rider L. G., Dougherty R. W., Niedel J. E. Phorbol diesters and dioctanoyl-glycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils. J. Immunol. 1988; 140: 200–206
  • Robinson J. M., Badwey J. A., Karnovsky M. L., Karnovsky M. J. Cell surface dynamics of neutrophils stimulated with phorbol esters or retinoids. J. Cell Biol. 1987; 105: 417–426
  • Sako T., Tauber A. I., Jeng A. Y., Yuspa S. H., Blumberg P. M. Contrasting action of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells. Cancer Res. 1988; 48: 4646–4650
  • Salzer W., Gerard C., Mc Call C. Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation. Biochem. Biophys. Res. Commun. 1987; 148: 747–754
  • Sato E. F., Tanaka Y., Utsumi K. cDNA cloning and nucleotide sequence of lipocortin-like 33 kDa protein in guinea pig neutrophils. FEBS 1989; 244: 108–112
  • Sha'afi R. I., Molski T. F. P. Activation of the neutrophils. Progress in Allergy, Vol. 42. Membrane Activation in Immunologically Relevant Cells, E. L. Becker. Karger, Basel 1988; 1–64
  • Sha'afi R. I., Molski T. F. P., Gomez-Cambronero J., Huang C. Dissociation of the 47-K protein phosphorylation from degranulation and superoxide production in neutrophils. J. Leukocyte Biol. 1988; 43: 18–27
  • Sha'afi R. I., Molski T. F. P., Huang C. K., Naccache P. H. The inhibition of neutrophil responsiveness, caused by phorbol ester is blocked by the protein kinase C inhibitor H7. Biochem. Biophys. Res. Commun. 1986; 137: 50–60
  • Sha'afi R. I., Shefcyk J., Yassin R., Molski T. F. P., Volpi M., Naccache P. H., White J. R., Feinstein M. B., Becker E. L. 1986. Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal-associated actin 1986; J. Cell Biol.: 1459–1463
  • Showell H. J., Williams D., Becker E. L., Naccache A. H., Sha'afi R. Desensitization and deactivatkm of the secretory responsiveness of rabbit neutrophils induced by the chemotactic peptide fMet-Leu-Phe. J. Reticuloendothel. Soc. 1979; 25: 139–150
  • Simchowitz L., Spilberg I., Atkinson J. P. Evidence that the functional responses of human neutrophils occur independently of transient elevations in cyclic AMP levels. J. Cyclic Nucleotide Protein Phosphoryl Res. 1983; 9: 35–47
  • Sklar L. A., Oades Z. G. 1985. Signal transduction and ligand-receptor dynamics in the neutrophil. Calcium modulation and restoration 1985; J. Biol. Chem.: 11468–11475
  • Skubitz K. M., Mendiola J. R., Collett M. S. CD15 monoclonal antibodies react with a phosphotyrosine containing protein on the surface of human neutrophils. J. Immunol. 1988; 141: 4318–4323
  • Slonczewski J. L., Wilde M. W., Zigmond S. H. Phosphorylase a activity as an indicator of neutrophil activation by chemotactic peptide. J. Cell Biol. 1985; 101: 1191–1197
  • Smith C. D., Uhing R. J., Snyderman R. G protein mediated activation of phospholipase C in human PMN is disrupted by phorbol esters. J. Biol. Chem. 1987; 262: 6121–6127
  • Smith R. J., Justen J. M., Sam L. M. L. Effects of a protein kinase C inhibitor K-252a, on human polymorphonuclear neutrophil responsiveness. Biochem. Biophys. Res. Commun 1988; 152: 1497–1503
  • Stoher S. J., Smolen J. E., Suchard S. J. Lipocortins I and II are major substrates of neutrophil protein kinase in vitro. FASEB J. 1989; A962, (abstract).
  • Takenawa T., Ishitoya J., Nagari Y. Inhibitory effect of prostaglandin E2, forskolin and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils. J. Biol. Chem. 1986; 261: 1092–1098
  • Tamoto K., Hazeki K., Nochi H., Mori Y., Koyama J. Phosphorylation of NADPH-cytochrome C reductase in guinea pig peritoneal macrophages stimulated with phorbol myristate acetate. FEBS Lett. 1989; 244: 159–162
  • Tao W., Molski T. F. P., Sha'afi R. I. Arachidonic acid release in rabbit neutrophils. Biochem. J. 1989; 257: 633–637
  • Tauber A. Protein kinase C and the activation of the human neutrophil NADPH-oxidase. Blood 1987; 69: 711–720
  • Tauzon P. T., Merrick W. C., Traugh J. A. Comparative analysis of phosphorylation of translational initiation and elongation factors by seven protein kinases. J. Biol. Chem. 1989; 264: 2773–2777
  • Tecoma E. S., Motulsky H. J., Traynor A. E., Omann G. M., Muller H., Sklar L. A. Transient catecholamine modulation of neutrophil activation: Kinetic and intracellular aspects of isoproterenol action. J. Leukocyte Biol. 1986; 540: 629–644
  • Traynor-Kaplan A. E., Harris A., Thompson B., Taylor P., Sklar L. An inositol tetrakiphosphate-containing phospholipid in activated neutrophils. Nature 1988; 334: 353–356
  • Treves S., Di Virgilio F., Vaselli G. M., Pozzan T. Effect of cytochalasins on cytosolic-free calcium concentration and phosphoinositide metabolism in leukocytes. Exp. Cell. Res. 1987; 168: 285–289
  • Truett A. P., Verghese M. W., Dillon S. B., Snyderman R. Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants. Proc. Natl. Acad. Sci. USA 1988; 85: 1549–1553
  • Tsai M., Yu C., Wei F., Stacey S. W. The effect of GTPase activating protein upon Ras is inhibited by mitogenically responsive lipids. Science 1989; 243: 522–526
  • Tschamer V. M., Prodhom B., Baggiolini M., Reuter H. Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. Nature 1986; 324: 369–372
  • Tsung P. K., Sakamoto T., Weissmann G. Protein kinase and phosphatases from human polymorphonuclear leukocytes. Biochem. J. 1975; 145: 437–448
  • Tyagi S. T., Tamura M., Burham D. N., Lambeth J. D. 1988. Phorbol myristate acetate augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis 1988; J. Biol. Chem.: 13191–13198
  • Verghese M. W., Fox K., Mc Phail L. C., Snyderman R. Chemoattractant elicited alternations of cAMP levels in human polymorphonuclear leukocytes require a Ca+2-dependent mechanism which is independent of transmembrane activation of adenylate cyclase. J. Biol. Chem. 1985; 260: 6769–6775
  • Volpi M., Naccache P. H., Molski T. F. P., Shefcyk J., Huang C-K., Marsh M. L., Munoz J., Becker E. L., Sha'afi R. I. Pertussis toxin inhibits fMet-Leu-Phe but not phorbol ester stimulated changes in rabbit neutrophils: Role of G proteins in excitation responses coupling. Proc. Natl. Acad. Sci. USA 1985; 182: 2708–2712
  • Wahl M. L., Nishibe S., Suh P., Rhee S. G., Carpenter G. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase CII independently of receptor internalization and excellular calcium. Proc. Natl. Acad. Sci. USA 1989; 86: 1568–1572
  • White J. R., Huang C-K., Hill J. M., Naccache P. H., Becker E. L., Sha'afi R. I. Effect of phorbol 12-myristate-13-acetate and its analogue 4 α-phorbol-12,13-di-decanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils. J. Biol. Chem. 1984; 259: 8605–8611
  • White J. R., Naccache A. H., Sha'afi R. I. 1983. Stimulation by chemotactic factor of actin association with the cytoskeleton in rabbit neutrophils. Effects of calcium and cytochalasin B 1983; J. Biol. Chem.: 14041–14047
  • Wilson E., Wang L., Mullin R. G., Uhlinger D. J., Liotta D. C., Lambeth J. D., Merrill A. M. Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors. J. Biol. Chem. 1988; 263: 9304–9309
  • Wright C. D., Hoffman M. D. The protein kinase C inhibition H-7 and H-9 fail to inhibit neutrophil activation. Biochem. Biophys. Res. Commun. 1986; 135: 749–755
  • Wright T. M., Hoffman R. D., Nishijima J., Jakoi L., Snyderman R., Shin H. S. Leukocyte chemoattraction by 1,2-diacyl-glycerol. Proc. Natl. Acad. Sci. USA 1988; 85: 1869–1873
  • Yaish P., Gazit A., Gilon C., Levitzki A. Blocking of EGF dependent cell proliferation by EGF receptor kinase inhibitors. Science 1988; 242: 933–935
  • Zigmond S. H., Slonczewski J. L., Wilde M. D., Carson M. PMN locomotion is insensitive to lowered cytoplasmic calcium level. Cell Motility and Cytoskeleton. 1988; 9: 184–189

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.