9
Views
5
CrossRef citations to date
0
Altmetric
Original Article

A trans-dominant mutation in human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp41 inhibits membrane fusion when expressed in target cells

, &
Pages 165-169 | Received 16 Mar 1994, Published online: 09 Jul 2009

References

  • Blumenthal R., Schoch C., Puri A., Clague M. J. A dissection of steps leading to viral envelope protein-mediated membrane fusion. Annals of the New York Academy of Sciences 1991; 635: 285–296
  • Bosch M. L., Earl P. L., Fargnoli K., Picciafuoco S., Giombini, Wong F., Staal F., Franchini G. Identification of the fusion peptide of primate immunodeficiency viruses. Science 1989; 244: 694–697
  • Buchschacher G. L., Jr., Freed E. O., Panganiban A. T. Cells induced to express a human immunodeficiency virus type 1 envelope gene mutant inhibit the spread of wild-type virus. Human Gene Therapy 1992; 3: 391–397
  • Dalgleish A. G., Beverley P. C. L., Clapham P. R., Crawford D. H., Greaves M. F., Weiss R. A. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 1984; 312: 763–767
  • Dimitrov D. S., Golding H., Blumenthal R. Initial stages of HIV-1 envelope glycoprotein-mediated cell fusion monitored by a new assay based on redistribution of fluorescent dyes. AIDS Research and Human Retroviruses 1991; 7: 799–805
  • Dimitrov D. S., Hillman K., Manischewitz J., Blumenthal R., Golding H. Correlation between kinetics of soluble CD4 interactions with HIV-1-envelope-expressing cells and inhibition of syncytia formation: implications for mechanisms of cell fusion and therapy for AIDS. AIDS 1992; 6: 249–256
  • Earl P. L., Hügin A. W., Moss B. Removal of cryptic poxvirus transcription termination signals from the human immuno-deficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus. Journal of Virology 1990; 64: 2448–2451
  • Earl P. L., Koenig S., Moss B. Biological and immunological properties of human immunodeficiency virus type 1 envelope glycoprotein: analysis of proteins with truncations and deletions expressed by recombinant vaccinia viruses. Journal of Virology 1991; 65: 31–41
  • Felser J. M., Klimkait T., Silver J. A syncytia assay for human immunodeficiency virus type 1 (HIV-1) envelope protein and its use in studying HIV-1 mutants. Virology 1989; 170: 566–570
  • Freed E. O., Risser R. Identification of conserved residues in the human immunodeficiency virus type 1 principal neutralizing determinant that are involved in fusion. AIDS Research and Human Retroviruses 1991; 7: 807–811
  • Freed E. O., Myers D. J., Risser R. Mutational analysis of the cleavage sequence of the human immunodeficiency virus type 1 envelope glycoprotein precursor gp160. Journal of Virology 1989; 63: 4670–4675
  • Freed E. O., Myers D. J., Risser R. Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41. Proceedings of the National Academy of Sciences 1990; 87: 4650–4654
  • Freed E. O., Delwart E. L., Buchschacher G. L., Jr, Panganiban A. T. A mutation in the human immuno-deficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity. Proceedings of the National Academy of Sciences, USA 1992; 89: 70–74
  • Gabuzda D. H., Lever A., Terwilliger E., Sodroski J. Effects of deletions in the cytoplasmic domain on biological functions of HIV-1 envelope glycoproteins. Journal of Virology 1992; 66: 3306–3315
  • Gallaher W. R. Detection of a fusion peptide sequence in the transmembrane protein of the human immunodeficiency virus. Cell 1987; 50: 327–328
  • Gallaher W. R., Ball J. M., Garry R. F., Griffin M. C., Montelaro R. C. A general model for the transmembrane proteins of HIV and other retroviruses. AIDS Research and Human Retroviruses 1989; 5: 431–440
  • Gething M.-J., Doms R. W., York D., White J. Studes on the mechanism of membrane fusion: site-specific mutagenesis of the hemagglutinin of influenza virus. Journal of Cell Biology 1986; 102: 11–23
  • Gonzalez-Scarano F., Waxham M., Ross A., Hoxie J. Sequence similarities between human immunodeficiency virus gp41 and paramyxovirus fusion proteins. AIDS Research and Human Retroviruses 1987; 3: 245–252
  • Helseth E., Kowalski M., Gabuzda D., Olshevsky U., Haseltine W., Sodroski J. Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants. Journal of Virology 1990a; 64: 2416–2420
  • Helseth E., Olshevsky U., Gabuzda D., Ardman B., Haseltine W., Sodroski J. Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion. Journal of Virology 1990b; 64: 6314–6318
  • Hillman K., Shapira-Nahor O., Gruber M. F., Hooley J., Manischewitz J., Seeman R., Yujcic L., Geyer S. J., Golding H. Chemically induced CD4 mutants of a human T cell Line. Journal of Immunology 1990; 144: 2131–2139
  • Klatzmann D., Champagne E., Chamaret S., Gruest J., Guetard D., Hercend T., Gluckman J.-C., Montagnier L. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 1984; 312: 767–768
  • Kowalski M., Potz J., Basiripour L., Dorfman T., Goh W. C., Terwilliger E., Dayton A., Rosen C., Haseltine W., Sodroski J. Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. Science 1987; 237: 1351–1355
  • Kowalski M., Bergeron L., Dorfman T., Haseltine W., Sodroski J. Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein. Journal of Virology 1991; 65: 281–291
  • Lifson J. D., Feinberg M. B., Reyes G. R., Rabin L., Banapour B., Chakrabarti S., Moss B., Wong-Staal F., Steiner K. S., Engleman E. G. Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein. Nature 1986; 323: 725–728
  • Mackett M., Smith G. L., Moss B. General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes. Journal of Virology 1984; 49: 857–864
  • Maddon P. J., Dalgleish A. G., McDougal J. S., Clapham P. R., Weiss R. A., Axel R. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 1986; 47: 333–348
  • McDougal J. S., Kennedy M., Sligh J., Cort S., Mowle A., Nicholson J. Binding of the HTLV-III/LAV to T4+T cells by a complex of the 110 K viral protein and the T4 molecule. Science 1986; 231: 382–385
  • Moss B., Earl P. L., Cooper N. Expression of proteins in mammalian cells using vaccinia. Current Protocols in Molecular Biology, F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, K. Struhl. Wiley, New York 1987; 16.15.1–16.18.10
  • Ratner L., Haseltine W., Patarca R., Livak K. J., Starcich B., Josephs S. F., Doran E. R., Rafalski J. A., Whitehorn E. A., Baumeister K., Ivanoff L., Petteway S. R., Jr, Pearson M. L., Lautenberger J. A., Papas T. S., Ghrayeb J., Chang N. Y., Gallo R. C., Wong-Staal F. Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature 1985; 313: 277–284
  • Schoch C., Blumenthal R. Role of the fusion peptide sequence in initial stages of influenza hemagglutinin-induced cell fusion. Journal of Biological Chemistry 1993; 268: 9267–9274
  • Sodroski J., Goh W. C., Rosen C., Campbell K., Haseltine W. A. Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature 1986; 322: 470–474
  • Wain-Hobson S., Sonigo P., Danos O., Cole S., Alizon M. Nucleotide sequence of the AIDS virus, LAV. Cell 1985; 40: 9–17
  • White J. M. Viral and cellular membrane fusion proteins. Annual Review of Physiology 1990; 52: 675–697

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.