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Original Article

The nervous system has an absolute molecular species requirement for proper function

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Pages 131-134 | Published online: 09 Jul 2009

References

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  • Salem N., Jr. Omega-3 fatty acids: molecular and biochemical aspects. New Protective Roles of Selected Nutrients in Human Nutrition, G. Spiller, J. Scala. Alan R. Liss, New York 1989; 109–228
  • Tinoco J. Dietary requirements and functions of alpha-linolenic acid in animals. Progress in Lipid Research 1982; 21: 1–45
  • Salem N., Jr, Ward G. R. Are omega-3 fatty acids essential nutrients for mammals. World Review of Nutrition and Dietetics 1993; 72: 128–147
  • Innis S. M. Essentially fatty acids in growth and development. Progress in Lipid Research 1991; 30: 39–103
  • Salem N. Alcohol, fatty acids and diet. Alcohol Health & Research World 1989; 13: 211–218
  • Galli C., Trzeciak H. I., Paoletti R. Effects of dietary fatty acids on the fatty acid composition of brain ethanolamine phosphoglyceride: reciprocal replacement of ω6 and ω3 polyunsaturated fatty acids. Biochimica et Biophysica Acta 1971; 248: 449–454
  • Salem N., Jr, Niebylski C. D. An evaluation of alternative hypotheses involved in the biological function of docosahexaenoic acid in the nervous system. Essential Fatty Acids and Eicosanoids, A. Sinclair, R. Gibson. American Oil and Chemical Society, Champaign 1992; 84–86
  • Salem N., Jr, Pawlosky R. J. Docosahexaenoic acid is an essential nutrient in the nervous system. Journal of Nutritional Science and Vitaminology 1992; 153–156, Special Issue
  • Kim H., Karanian J. W., Shingu T., Salem N. Stereochemical analysis of hydroxylated docosahexaenoates. Prostaglandins 1990; 40: 473–490
  • Kim H., Sawazaki S., Salem N., Jr. Lipoxygenation in rat brain. Biochemical and Biophysical Research Communications 1991; 174: 729–734
  • Kim H., Sawazaki S., Salem N., Jr. Lipoxygenation of polyunsaturated fatty acids in rat brain?. Essential Fatty Acids and Eicosanoids, A. Sinclair, R. Gibson. American Oil and Chemical Society, Champaign 1992; 145–147
  • Karanian J. W., Kim H., Shingu T., Salem N. Inhibitory efffects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619)-induced smooth muscle contraction. Journal of Pharmacology and Experimental Therapeutics 1994, in press
  • Hullin F., Bossant M. J., Salem N., Jr. Aminophospholipid molecular species asymmetry in the human erythrocyte plasma membrane. Biochimica et Biophysica Acta 1991; 1061: 15–25
  • Bougnoux P., Salem N., Jr, Lyons C., Hoffman T. Alteration in the membrane fatty acid composition of human lymphocytes and cultured transformed cells induced by interferon. Molecular Immunology 1985; 22: 1107–1113
  • Abood L. G., Salem N., Jr, MacNeil M., Bloom L., Abood M. E. Enhancement of opiate binding by various molecular forms of phosphatidylserine and inhibition by other unsaturated lipids. Biochimica et Biophysica Acta 1977; 468: 51–62
  • Salem N., Jr, Serpentino P., Puskin J. S., Abood L. G. Preparation and spectroscopic characterization of molecular species of brain phosphatidylserines. Chemistry and Physics of Lipids 1980; 27: 289–304
  • Salem N., Jr, Abood L. G., Hoss W. Separation of brain phosphatidylserines according to degree of unsaturation by thin-layer chromatography. Analytical Biochemistry 1976; 76: 407–415
  • Mitchell D. C., Straume M., Litman B. J. Role of sn-1-saturated, sn-2-polyunsaturated phospholipids in control of membrane receptor conformation equilibrium: effects of cholesterol and acyl chain unsaturation on the metarhodopsin I — metarhodopsin II equilibrium. Biochemistry 1992; 31: 662–670
  • Slater S. J., Kelly M. B., Taddeo F. J., Ho C., Rubin E., Stubbs C. D. The modulation of protein kinase C activity by membrane lipid bilayer structure. Journal of Biological Chemistry 1994; 269: 4866–4871
  • Hullin F., Kim H. Y., Salem N., Jr. Analysis of aminophospholipid molecular species by high performance liquid chromatography. Journal of Lipid Research 1989; 30: 1963–1975

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