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Research Article

A typical Antipsychotic Induced Weight Gain: Pathophysiology and Management

, M.D., , , M.D., , M.D., , B.A. & , M.D.
Pages 75-85 | Published online: 04 Dec 2011

References

  • Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL: Overweight and obesity in the United States: prevalence and trends, 1960-1994. In J Obes Relat Metab Disord 1998; 22(1):39–47.
  • National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obesity Res 1998; 6\(suppl 2):50s–63s.
  • Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemic of obesity and diabetes in the United States. JAMA 2001; 286:1195–1200.
  • Gordon HL, Law A, Hohman KE. The problem of over-weight in hospitalized psychotic patients. Psychiatry Quarterly 1960; 34:69–82.
  • Allison DB, Fontaine KR, Moonseong H. The distribu-tion of body mass index among individuals with and without schizophrenia. J Clin Psych 1999; 60:215–220.
  • Gopalaswamy AK, Morgan R. Too many chronic mentally disabled patients are too fat. Acta Psychitr Scand 1985; 72:254–258.
  • Tsuang MT, Perkins K, Simpson JC. Physical diseases in schizophrenia and affective disorder. J Clin Psych 1983; 44(2):42–46.
  • Ananth J, Venkatesh, R, Burgoyne K, Gunatilake S: Atypical antipsychotic drug use and diabetes. Psycho-somatics and Psychotherapy 2002; 71:244–254.
  • Bernstein JG: Induction of obesity by psychotropic drugs. Annals of the New York Academy of Sciences 1987; 499:203–215.
  • Baptista T. Bodyweight gain induced by antipsychotic drugs: Mechanisms and management. Acta Psych Scand 1999; 100:3–16.
  • Klett CJ, Caffey EM Jr. Weight changes during treat-ment with phenothiazine derivatives. J Neuropsych 1960; 2:102–108.
  • Holden JM, Holden UP. Weight changes with schizo-phrenic psychosis and psychotropic drug therapy. Psy-chosomatics 1970; 11(6):551–561.
  • Branchey MH, Lee JH, Amin R, Simpson GM. High-and low-potency neuroleptics in elderly psychiatric patients. JAMA 1978; 239(18):1860–1862.
  • Silverstone T, Smith G, Goodall E. Prevalence of obe-sity in patients receiving depot antipsychotics. Br J Psych 1988; 153:214–217.
  • Dufresne RL, Valentino D, Kass DJ. Thioridazine improves affective symptoms in schizophrenic patients. Psychopharm Bull 1993; 29(2):249–255.
  • Doss FW. The effect of antipsychotic drugs on body weight: a retrospective review. J Clin Psych 1979; 40:528–530.
  • Bernstein JG: Psychotropic drug induced weight gain: mechanisms and management. Clin Neuropharm 1988; 11\(suppl 1):s194–s206.
  • Rockwell WJ, Ellinwood EH Jr., Trader DW: Psychotro-pic drugs promoting weight gain: health risks and treat-ment implications. S Med Jour 1983; 76(11):1407–1412.
  • Brady, KT. Weight gain associated with psychotropic drugs. S Med Jour 1989; 82:611–617.
  • Bhavnani SM, Levin GM. Antipsychotic agents: A survey of the prevalence, severity and burden of side effects. Int Clin Psychopharm 1996; 11(1):1–12.
  • Allison DB, Casey DE. Antipsychotic-induced weight gain: a review of the literature. J Clin Psych 2001; 62\(suppl 7):22–31.
  • Casey DE. The relationship of pharmacology to side effects. J Clin Psych 1997; 58\(suppl 10):55–62.
  • Lieberman JA, Kane JM, Johns CA. Clozapine: guide-lines for clinical management. J Clin Psych 1989; 50:329–338.
  • Naber D, Hippius H. The European experience with clozapine. Hosp Comm Psych 1990; 41:886–890.
  • Povlsen UJ, Noring U, Fog R, Gerlach J. Tolerability and therapeutic effect of clozapine: a retrospective investigation of 216 patients treated with clozapine for up to 12 years. Acta Psych Scand 1985; 71:176–185.
  • Hummer M, Kemmler WC, Kurz M, Kurzthaler I, Oberbauer H, Fleischhacker WW. Weight gain induced by clozapine. Eur Neuropsychopharm 1995; 5(4): 437–440.
  • Wirshing DA, Wirshing WC, Kysar L, Berisford MA, Goldstein D, Pashdag J, Mintz J, Marder SR. Novel antipsychotics: Comparison of weight gain liabilities. J Clin Psych 1999; 60(6):358–363.
  • Tran PV, Hamilton SH, Kuntz AJ. Double-blind com-parison of olanzapine versus risperidone in the treat-ment of schizophrenia and other psychotic disorders. J Clin Psychopharm 1997; 17:407–418.
  • Tohen M, Zarate CA. Antipsychotic agents and bipolar disorder. J Clin Psych 1998; 59\(suppl 1):38–48.
  • Guille C, Sachs GS, Ghaemisn. A naturalistic compari-son of clozapine, risperidone, and olanzapine in the treatment of bipolar disorder. J Clin Psych 2000; 61(9):638–642.
  • Frankenburg FR, Zanarini MC, Kando J, Centorrino F. Clozapine and body mass change. Biol Psych 1998; 43:520–524.
  • George TP, Sernyak MJ, Ziedonis DM, Woods SW. Effects of clozapine on smoking in chronic schizo-phrenic outpatients. J Clin Psych 1995; 156:344–346.
  • Grunberg NE:Smoking cessation and weight gain. N Engl J Med. 1991; 324:768–769.
  • Bustillo JR, Buchanan RW, Irish D, et al. Differential effect of clozapine on weight: a controlled study. Am J Psychiatry. 1996; 153:817–819.
  • Jalenques I, Tauveron I, Albuisson E, et al. [Weight gain and clozapinel (Fre) Encephale 1996; 22(spec no 3): 77–79.
  • Leadbetter R, Shutty M, Pavalonis D, Vieweg V, Higgins P, Downs M. Clozapine induced weight gain: prevalence and clinical relevance. Am J Psych 1992; 149:68–72.
  • Bai YM, Lin CC, Chen JY, Lin CY: Weight gain among patients on clozapine. Psych Ser 1999; 50(5): 704–705.
  • Lamberti JS, Bellnier T, Schwarzkopf SB. Weight gain among schizophrenic patients treated with clozapine. Am J Psychiatry 1992; 149:689–690.
  • Umbricht DS, Pollack S, Kane JM. Clozapine and weight gain. J Clin Psychiatry 1994; 55(suppl B):157–160.
  • Zhang ZJ, Yao ZJ, Zhang XB, et al: No association of antipyschotic agent-induced weight gain with a DA receptor gene polymorphism and therapeutic response. Acta Pharmacol Sin 2003; 24:235–240.
  • Marder SR, Meibach RC. Risperidone in the treatment of schizophrenia. Am J Psych 1994; 151(6):825–835.
  • Csernansky JG, Mahmoud R, Brenner R. A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia. New Eng J Med 2002; 348:16–22.
  • Conley RR, Mahmoud R, and Risperidone Study Group: A randomized double-blind study of risperidone and olanzapine in patients with schizophrenia and schizoaf-fective disorder. Am J Psychiatry 2001; 158: 765–774.
  • Peuskens JA. On behalf of Risperdione Study Group: Risperidone in the treatment of patients with chronic schizophrenia: a multinational multicenter double-blind parallel group study versus haloperidol. Br J Psych 1995; 166:712–726.
  • Hoyberg OJ, Fensbo C, Remvig J, Lingjaerde O, Sloth-Nielsen M, Slavesen I. Risperidone versus perphena-zine in the treatment of chronic schizophrenic patients with acute exacerbations. Ada Psychiatr Scand 1993; 88:395–402.
  • Csernansky J, Okamoto A. Risperidone versus halo-peridol in the prevention of relapse in chronic schizo-phrenia and schizoaffective disorders: a long-term double blind comparison. Eur Neuropsychopharm 1999; 9\(suppl 5):s268p.
  • Cohen S, Glazewski R, Khan S, Khan A. Weight gain with risperidone among patients with mental retard-ation: effect of calorie restriction. J Clin Psych 2001; 62:114–116.
  • Arvanitis LA, Miller BG. Multiple fixed doses of "seroquel" (quetiapine) in patients with acute exacerba-tion of schizophrenia: a comparison with haloperidol and placebo. The Seroquel Trial 13 Study Group. Bio Psych 1997; 42(4): 233–246 .
  • Peuskens JA. Comparison of quetiapine and chlorpro-mazine in the treatment of schizophrenia. Ada Psych Scand 1997; 96:265–273.
  • Small JG, Hirsch SR, Arvanitis LA. Quetiapine in patients with schizophrenia. Arch Gen Psych 1997; 54:549–557.
  • Tandon R, Harrigan E, Zorn S. Ziprasidone: a novel antipsychotic with unique pharmacology and therapeu-tic potential. J Serotonin Res 1997; 4:159–177.
  • Daniel DG, Zimbroff DL, Potkin SG, Reeves KR, Harrigan EP, Lakshminarayanan M. Ziprasidone 80 mg/day and 160 mg/day in the acute exacerbation of schizophrenia and schizoaffective disorder: a six week placebo controlled trial. Neuropsychopharm 1999; 20(5):491–505.
  • Keck P Jr., Buffenstein A, Ferguson J, Feighner J, Jaffe W, Harrigan EP, Morrissey MR. Ziprasidone 40 and 120 mg/day in the acute exacerbation of schizophrenia and schizoaffective disorder: a 4 week placebo con-trolled trial. Psychopharm 1998; 140(2): 173–184.
  • Weiden P, Simpson G, Kramer T: Switching from olanzapine to ziprasidone: clinical effects. Eur Neuro-psychopharm 1999; 9\(suppl 5):s264.
  • Simpson G, Potkin S, Switch Study Group. Switching from risperidone to ziprasidone. Eur Neuropsycho-pharm 1999; 9\(suppl 5):s265.
  • Arato MO, O'Connor R, Meltzer H. Ziprasidone inves-tigators Study Group. Ziprasidone: efficacy in the prevention of relapse and in the long-term treatment of negative symptoms of chronic schizophrenia. Eur Neuro-psychopharm 1997; 7\(suppl 2):5214.
  • Beasley CM Jr, Tollefson GD, Tran PV. Safety of olan-zapine. J Clin Psych 1997; 58\(suppl 10):13–17.
  • Zyprexa PDR: Physician's Desk Reference. Montvale, N.J., Med Econ 1999; 1641–1645.
  • Sachs GS, Guille C. Weight gain associated with use of psychotropic medications. J Clin Psych 1999; 60\(suppl 21):16–19.
  • Conley RR, Meltzer HY: Adverse events related to olanzapine. J Clin Psych 2000; 61\(suppl 8):26–29; discussion 30.
  • Gupta, S, Droney T, Al-Samarrai S, Keller P, Frank B. Olanzapine induced weight gain. Ann Clin Psych 1999; 10:39.
  • Robinson RG, McHugh PR, Folstein MF. Measurement of appetite disturbances in psychiatric disorders. J Psych Res 1975; 12:59–68.
  • Amdisen A. Drug produced obesity. Experiences with chlorpromazine, perphenazine, and clopenthixol. Dan Med Bull 1964; 11:182–189.
  • Johnson DAW, Breen M: Weight changes with depot neuroleptic maintenance therapy. Ada Psych Scand 1979; 59:525–528.
  • Umbricht DSG, Pollack S, Kane JM. Clozapine and weight gain. J Clin Psych 1994; 55(suppl B):157–160.
  • Stanton JM. Weight gain associated with neuroleptic medication: a review. Schiz Bull 1995; 21:463–472.
  • Kinon B, Basson B, Gilmore JA, Tollefson GD. Long-term olanzapine treatment: weight change and weight related health factors in schizophrenia. J Clin Psych 2001; 62:92–100.
  • Henderson D, Cagliero E, Gray C, Nasrallah RA, Hayden DL, Schonfeld DA, Goff DC. Clozapine, diabetes mellitus, weight gain and lipid abnormalities: a five year naturalistic study. Am J Psych 2000; 57(6):975–981.
  • Sahu A, Kalra SP. Neuropeptide regulation of feeding behavior: neuropeptide Y. Trends in Endocrinology and Metabolism 1993; 4:217–224.
  • Casey DE, Zorn SH. The pharmacology of weight gain with antipsychotics. J Clin Psych 2001; 62\(suppl 7):4–10.
  • Yanovski JA, Yanovski SZ. Recent advances in basic obesity research. JAMA 1999; 282:1504–1506.
  • Thornton-Jones, Z, Neill JC, Reynolds GP. The atypical antipsychotic olanzapine enhances ingestive behavior in the rat: A preliminary study. J Psychopharmacology 2002; 16:35–37.
  • Kaur G, Srinivas K, Kulkarni K: Studies on modulation of feeding behavior by atypical antipsychotics in female mice. Progress in Neuro-psychopharmacology & Biological Psychiatry 2002; 26:277–285.
  • Baptista, T, Parada M, Hernadez L. Long term administra-tion of some antipsychotic drugs increases bodyweight and feeding in rats: are dopamine receptors involved? Pharmacol Biochem Behav 1987; 27:399–405.
  • Baptista T, Reyes D, Hernandez L: Antipsychotic drugs and reproductive hormones: relationship to body weight regulation. Pharmacol Biochem Behav 1999; 62:409–417.
  • Ellinwood VL, Miller D, Schultz SK, Wehring H, Arndt S. CYP2D6 polymorphisms and atypical antipsychotic weight gain. Psychiatric Genetics 2002; 12: 55–58.
  • Dourish CT. Multiple serotonin receptors-opportun-ities for new treatments for obesity. Obesity Res 1995;
  • Jackson HC, Heal DJ. A comparison of 5HT releasing agents and reuptake inhibitors as antiobesity drugs. Neurosci News 1999; 2(6):12–21.
  • Stromborn U, Krotkiewski M, Blennow, J, Mansson JE, Ekman R, Bjorntorp P. The concentration of monoamine metabolites and neuropeptides in the cerebrospinal fluid of obese women with different body fat distribution. Int J Obesity Related Metabolic Disorders 1996; 20:361–368.
  • Davis R, Faulds D. Dexfenfluramine. An updated review of its therapeutic use in the management of obesity. Drugs 1996; 52:696–724.
  • McGuirk J, Muscat R, Wilner P. Effects of chronically administered fluoxetine and fenfluramine on food intake, body weight and the behavioral satiety sequence. Psychopharmacology 1992; 106:401–407.
  • Lightowler S, Wood M, Brown T, Glen A, Blackburn T, Tulloch I, Kennett G. An investigation of the mechanism responsible for fluoxetine induced hypophagia in rats. Eur J Pharmacology 1996; 296:137–143.
  • Victor IR. Olanzapine: a novel atypical neuroleptic agent. Lancet 1997; 394:1264–1265.
  • Terry P, Katz JL. A comparison of the effects of DI receptor antagonist SCH 23390 and SCH 39166 on suppression of feeding behavior by the D1 agonist SKF 38393. Psychopharmacology 1994; 113:328–333.
  • Terry P, Katz JL. Differential antagonism of the effects of dopamine DI-receptor agonist on feeding behavior in the rats. Psychopharmacology 1992; 109: 403–409.
  • Goldstein JM. The new generation of antipsychotic drugs: how atypical are they? Int J Neuropsychopharma-cology 2000; 3(4):339–349.
  • Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 1995; 374(6522):542–546.
  • Lawson WB, Byrd J, Reed D. Effects of neuroleptics on food intake. Soc Neurosci Abstract 1984; 303:68–72.
  • Leibowitz SF, Rossakis C. Pharmacological character-ization of perifornical hypothalamus dopamine receptors mediating feeding inhibition in the rat. Brain Res 1979; 172:115–130.
  • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neu-ral networks. Science 1995; 269(5223):546–549.
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 22:263–770.
  • Kraus T, Haack M, Schuld A, Hinze-Selch D, Kuhn M, Uhr M, Pollmacher T. Body weight and leptin plasma levels during treatment with antipsychotic drugs. Am J Psychiatry 1999; 156:321–324.
  • Baptista T, Lacruz A, De Mendoza D, Mendoza JM, Silvera R, Angeles I, Mendoza MT, Hernandez L. Body weight gain after administration of antipsy-chotic drugs: correlation with leptin, insulin, and reproductive hormones. Pharmacopsychiatry 2000; 33:81–88.
  • Baptista T, Lacruz A, Mendoza S, Hernandez L. Endocrine effects of lithium carbonate in healthy post menopausal women: relationship with body weight regulation. Biol Psychiatry 2000; 24:1–16.
  • Melkersson KI, Hulling AL, Brismar KE. Elevated levels of insulin, lepin, and blood lipids in olanzap-ine treated patients with schizophrenia or related pychoses. J Clin Psych 2000; 61(10):742–749.
  • Ahren B, Larsson H, Wilhelmsson C, Nasman B, Olsson T. Regulation of circulating leptin in humans. Endocrine 1997; 7(1):1–8.
  • Baptista T, Beaulieu S. Are leptin and cytokines involved in body weight gain during treatment with antipsychotic drugs? Can J Psychiatry 2002; 47: 742–749.
  • Yamaguchi T, Kamon J, Waki H, et al. The fat derived hormone adiponectin reverses insulin resis-tance associated with both lipoatrophy and obesity. Nature Medicine 2001; 7:941–946.
  • Pollmacher T, Hinze-Selch D, Mullington J. Effects of clozapine on plasma cytokine and soluble cyto-kine receptor levels. J Clin Psychopharm 1996; 16(5):403–409.
  • Hinze-Selch D, Deuschle M, Weber B, Heuser I, Pollmacher T. Effect of co-administration of clozap-ine and fluvoxamine versus clozapine monotherapy on blood cell counts plasma levels of cytokines and bodyweight. Psychopharm 2000; 149:163–169.
  • Argiles JM, Lopez-Soriano J, Busquets S, Lopez-Soriano FJ. Journey from cachexia to obesity by TNF. FASEB 1997; 11:743–751.
  • Auwerx J, Staels B. Leptin. Lancet 1998; 351:737–742.
  • Fontaine KR, Heo M, Harrigan EP, et al. Estimating the consequences of antipsychotic induced weight gain on health and mortality rate. Psych Res 2001; 101(3):277–288.
  • Hauner H. The impact of pharmacotherapy on weight management in type 2 diabetes. In J Obes 1999; 23(Suppl 7):S12–S17.
  • Winkelman JW. Schizophrenia obesity and obstructive sleep apnea. J Clin Psych 2001; 62:8–11.
  • Rankinen T, Perusse L, Weisnagel SJ, Snyder EE, Chagon YC, Bouchard C. The human obesity gene map: the 2001 update. Obes Res 2002; 10(3): 196–243.
  • Froguel P. Boutin P. Genetics of pathways regulating body weight in the development of obesity in humans. Exp Biol Med 2001; 226(11):991–996.
  • Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 2002; 13(1):18–23.
  • Boelsterli UA, Bedoucha M. Toxicological conse-quences of altered peroxisome proliferator-activated receptor gamma (PPA Rgamma) expression in the liver: insights from models of obesity and type 2 diabetes. Biochem Pharmacol 2002; 63(1):1–10.
  • Reinstein MJ, Sirotovskaya LA, Jones LE, Mohan S, Chasanov M. Effect of clozapine-quetiapine combina-tion therapy on weight and glycaemic control: prelim-inary findings. Clin Drug Inves 1999; 18:99–104.
  • Jimerson DC, Lesem MD, Kaye WH, Hegg AP, Brewerton TD. Eating disorders and depression: is there a serotonin connection? Bio Psych 1991; 28(5):443–454.
  • Grinspoon S, Gulick T, Askari H, et al. Serum leptin levels in women with anorexia nervosa. J Clin Endocrin Metab 1996; 81:3861–3863.
  • Kaye WH, Gwirtsman HE, George DT, Ebert MH. Altered serotonin activity in anorexia nervosa after long-term weight restoration: does elevated cerebro-spinal fluid 5-Hydroxyindoleacetic acid level correlate with rigid and obsessive behavior? Arch Gen Psych 1991; 48(6):556–562.
  • Sullivan PF. Mortality in anorexia nervosa. Am J Psych 1995; 152:1073–1074.
  • Rigotti NA, Neer RM, Skates SJ, Herzog DB, Nussbaum SR. The clinical course of osteoporosis in anorexia nervosa. JAMA 1990; 265(9):1133–1138.
  • Klibanski A, Biller BMK, Schoenfeld D, Herzog DB, Saxe V. The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J Clin Endocrin Met 1995; 80(3): 898–904 .
  • Werneke U, Taylor D, Sanders TAB. Options for pharmacological management of obesity in patients treated with atypical antipsychotics. In Clinical Psychopharmacology 2002; 17:145–160.
  • Wirth A. Long term weight loss with sibutramine: A randomized controlled trial. JAMA 2001; 286: 1331–1339.
  • Angelescu I, Klawe C, Benkert O. Orlistat in the treat-ment of psychopharmacologically induced weight gain. J Clin Psychopharm 2000; 20:716–717.
  • Benazzi F. Depression induced by Orlistat (Xenecal). Can J Psychiatry 2000; 45:87.
  • Morrison JA, Cottingham EM, Barton BA. Metformin for weight loss in pediatric patients taking psychotro-pic drugs. Am J Psychiatry 2002; 159:655–657.
  • Hutchison TA, Sharhan DR. DRUGDEX system. Greenwood Village, CO: Micromedex, Inc.; 2001.
  • Levy E, Margolese HC, Chouinard G. Topiramate produced weight loss following olanzapine induced weight gain in schizophrenia. J Clin Psychiatry 2002; 63:1045.
  • Ketter TA, Post RM, Theodore WH. Positive and neg-ative psychiatric effects on antiepileptic drugs in patients with seizure disorders. Neurology 1999; 53\(suppl 2):S53–S67.
  • Dursun SM, Devarajan S. Clozapine weight gain, plus topiramate weight loss. Can J Psych 2000; 45(2): 198.
  • Correa N, Opler LA, Kay SR, Birmaher B. Amanta-dine in the treatment of neuroendorine side effects of neuroleptics. J Clin Psychopharm 1987; 7:91–95.
  • Floris M, Lejeunne J, Deberdt W. Effect of amanta-dine on weight gain during olanzapine treatment. Eur J Neuropsychopharmacology 2002; 11:181–182.
  • Wilcox J, Tsuang J. Psychological effects of amanta-dine on psychotic subjects. Neuropsychobiology 1990; 23:144–146.
  • Sachetti E, Guarner L, Bravi D. H(2) antagonist niza-tidine may control olanzapine-associated weight gain in schizophrenic patients. Biol Psychiatry 2000; 48:167–168.
  • Stoa-Birketvedt G, Waldum HL, Vonen B, Florholmen J. Effect of cimetidine on basal and postprandial plasma concentrations of cholecystokinin and gastrin in humans. Acta Physiol Scand 1997; 159(4):321–325.
  • Stoa-Birketvedt G, Paus PN, Gnass R. Cimetidne reduces weight gain and improves metabolic control in overweight patients with type 2 diabetes. J Obes Relat Metab Disord 1998; 22:1041–1045.

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