1
Views
2
CrossRef citations to date
0
Altmetric
Original Article

An Open-Label Study to Evaluate Switching from an SSRI or SNRI to Tiagabine to Alleviate Antidepressant-Induced Sexual Dysfunction in Generalized Anxiety Disorder

, , , , , & show all
Pages 25-30 | Published online: 04 Dec 2011

References

  • Kessler RC, McGonagle KA, Zhao S, et al.: Lifetime and 12- month prevalence of DSM-III-R psychiatric disorders in the United States: Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51: 8–19
  • Wittchen HU, Zhao S, Kessler RC, et al.: DSM-III-R generalized anxiety disorder in the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51:355–364
  • Rickels K, Schweizer E: The clinical course and long-term management of generalized anxiety disorder. J Clin Psychopharmacol 1990; 10 (Suppl):101S–110S
  • Angst J, Vollrath M: The natural history of anxiety disorders. Acta Psychiatr Scand 1991; 84:446–452
  • Massion AO, Warshaw MG, Keller MB: Quality of life and psychiatric morbidity in panic disorder and generalized anxiety disorder. Am J Psychiatry 1993; 150:600–607
  • Kaufman J, Charney D: Comorbidity of mood and anxiety disorders. Depress Anxiety 2000; 12 (Suppl 1):69–76
  • Kessler RC, Wittchen HU: Patterns and correlates of generalized anxiety disorder in community samples. J Clin Psychiatry 2002; 63 (Suppl 8):4–10
  • Davidson JRT: Pharmacotherapy of generalized anxiety disorder. J Clin Psychiatry 2001; 62 (Suppl 11):46–60
  • Rickels K, Rynn M: Pharmacotherapy of generalized anxiety disorder. J Clin Psychiatry 2002; 63 (Suppl 14):9–16
  • Clayton AH, Warnock JK, Kornstein SG, et al.: A placebocontrolled trial of bupropion SR as an antidote for selective serotonin reuptake inhibitor-induced sexual dysfunction. J Clin Psychiatry 2004; 65:62–67
  • Montgomery SA, Henry J, McDonald G, et al.: Selective serotonin reuptake inhibitors: meta-analysis of discontinuation rates. Int Clin Psychopharmacol 1994; 9:47–53
  • Bonierbale M, Lancon C, Tignol J: The ELIXIR study: Evaluation of sexual dysfunction in 4557 depressed patients in France. Curr Med Res Opin 2003; 19:114–124
  • Rosen RC, Marin H: Prevalence of antidepressant-associated erectile dysfunction. J Clin Psychiatry 2003; 64 (Suppl 10):5–10
  • Derogatis LR: Sexual function and quality of life: Endpoints and outcomes. J Gend Specif Med 2001; 4:35–42
  • Rosenberg KP, Bleiberg KL, Koscis J, Gross C: A survey of sexual side effects among severely mentally ill patients taking psychotropic medications: Impact on compliance. J Sex Marital Ther 2003; 29:289–296
  • Montejo AL, Llorca G, Izquierdo JA: Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. J Clin Psychiatry 2001; 62 (Suppl 3):10–21
  • Nutt DJ: Neurobiological mechanisms in generalized anxiety disorder. J Clin Psychiatry 2001; 62 (Suppl 11):22–27
  • Lydiard RB: The role of GABA in anxiety disorders. J Clin Psychiatry 2003; 64 (Suppl 3):21–27
  • Fink-Jensen A, Suzdak PD, Swedberg MD, et al.: The gammaaminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. Eur J Pharmacol 1992; 220:197–201
  • Borden LA, Murali Dhar TG, Smith KE, et al.: Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 1994; 269: 219–224
  • Rosenthal M: Tiagabine in the treatment of generalized anxiety disorder: A randomized, open-label, clinical trial with paroxetine as a positive control. J Clin Psychiatry 2003; 64:1245–1249
  • Pollack MH, Roy-Byrne PP, Van Ameringen M, et al.: The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: Results of a placebo-controlled study. J Clin Psychiatry 2005; 66:1401–1408
  • Sheehan DV, Lecrubier Y, Sheehan KH, et al.: The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin Psychiatry 1998; 59\(Suppl 20): 22–33
  • Hamilton M: The assessment of anxiety states by rating. Br J Med Psychol 1959; 32:50–55.
  • Zigmond AS, Snaith RP: The Hospital Anxiety and Depression Scale. Acta Pscyhiatr Scand 1983; 67:361–370
  • McGahuey CA, Gelenberg AJ, Laukes CA, et al.: The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther 2000; 26:25–40
  • Delgado PL, Brannan SK, Mallinckrodt CH, et al.: Sexual functioning assessed in 4 double-blind placebo- and paroxetinecontrolled trials of duloxetine for major depressive disorder. J Clin Psychiatry 2005; 66: 686–692
  • Piazza LA, Markowitz JC, Kocsis JH, et al.: Sexual functioning in chronically depressed patients treated with SSRI antidepressants: A pilot study. Am J Psychiatry 1997; 154:1757–1759
  • Gelenberg AJ, McGahuey C, Laukes C, et al.: Mirtazapine substitution in SSRI-induced sexual dysfunction. J Clin Psychiatry 2000; 61:356–360
  • Masand PS, Ashton AK, Gupta S, Frank B: Sustained-release bupropion for selective serotonin reuptake inhibitor-induced sexual dysfunction: A randomized, double-blind, placebocontrolled, parallel-group study. Am J Psychiatry 2001; 158:805–807
  • Saiz-Ruiz J, Montes JM, Ibanez A, et al.: Assessment of sexual functioning in depressed patients treated with mirtazapine: A naturalistic 6-month study. Hum Psychopharmacol 2005; 20: 435–440
  • Ashton AK, Mahmood A, Iqbal F: Improvements in SSRI/SNRIinduced sexual dysfunction by switching to escitalopram. J Sex Marital Ther 2005; 31:257–262
  • Taylor MJ, Rudkin L, Hawton K: Strategies for managing antidepressant- induced sexual dysfunction: Systematic review of randomized controlled trials. J Affect Disord 2005; 88:241–254

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.