References
- Bukreyev AA, Chandran K, Dolnik O, et al. Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013. Arch Virol 2014;159:821–30.
- Baize S, Pannetier D, Oestereich L, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med 2014;371:1418–25.
- Gire SK, Goba A, Andersen KG, et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science 2014;345:1369–72.
- Bausch DG, Schwarz L. Outbreak of Ebola virus disease in Guinea: where ecology meets economy. PLoS Negl Trop Dis 2014;8:e3056.
- Bah EI, Lamah MC, Fletcher T, et al. Clinical presentation of patients with Ebola virus disease in Conakry, Guinea. N Engl J Med 2015;372:40–7.
- Lyon GM, Mehta AK, Varkey JB, et al. Clinical care of two patients with Ebola virus disease in the United States. N Engl J Med 2014;371:2402–9.
- Meyers L, Frawley T, Goss S, et al. Ebola virus outbreak 2014: clinical review for emergency physicians. Ann Emerg Med 2015;65:101–8.
- Yamin D, Gertler S, Ndeffo-Mbah ML, et al. Effect of Ebola progression on transmission and control in Liberia. Ann Intern Med 2015;162:11–17.
- Tseng CP, Chan YJ. Overview of Ebola virus disease in 2014. J Chin Med Assoc 2015;78:51–5.
- Nyenswah T, Fahnbulleh M, Massaquoi M, et al. Ebola epidemic-Liberia, March-October 2014. MMWR Morb Mortal Wkly Rep 2014;63:1082–6.
- You JQ. An improved ward architecture for treatment of patients with Ebola virus disease in Liberia. Am J Trop Med Hyg 2016. [Epub ahead of print]. doi: 10.4269/ajtmh.15-0209.
- Centers for Disease Control and Prevention (CDC). Diagnosis. [Online] 14 November 2014. [Updated] 25 April 2015. Available from: http://www.cdc.gov/vhf/ebola/diagnosis/index.html [last accessed 17 Sep 2015].
- Beeching NJ, Fenech M, Houlihan CF. Ebola virus disease. BMJ 2014;349:g7348.
- World Health Organization (WHO). Laboratory guidance for the diagnosis of Ebola virus disease: interim recommendations. [Online] 19 Septermber 2014. Available from: http://apps.who.int/iris/handle/10665/134009 [last accessed 17 Sep 2015].
- Saijo M, Niikura M, Ikegami T, et al. Laboratory diagnostic systems for Ebola and Marburg hemorrhagic fevers developed with recombinant proteins. Clin Vaccine Immunol 2006;13:444–51.
- Drosten C, Gottig S, Schilling S, et al. Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. J Clin Microbiol 2002;40:2323–30.
- Gibb TR, Norwood DA, Jr, Woollen N, et al. Development and evaluation of a fluorogenic 5' nuclease assay to detect and differentiate between Ebola virus subtypes Zaire and Sudan. J Clin Microbiol 2001;39:4125–30.
- Ksiazek TG, Rollin PE, Jahrling PB, et al. Enzyme immunosorbent assay for Ebola virus antigens in tissues of infected primates. J Clin Microbiol 1992;30:947–50.
- Ksiazek TG, Rollin PE, Williams AJ, et al. Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995. J Infect Dis 1999;179:S177–87.
- Ksiazek TG, West CP, Rollin PE, et al. ELISA for the detection of antibodies to Ebola viruses. J Infect Dis 1999;179:S192–8.
- Leroy EM, Baize S, Lu CY, et al. Diagnosis of Ebola haemorrhagic fever by RT-PCR in an epidemic setting. J Med Virol 2000;60:463–7.
- Wang YP, Zhang XE, Wei HP. Laboratory detection and diagnosis of filoviruses. Virol Sin 2011;26:73–80.
- Huang Y, Wei H, Wang Y, et al. Rapid detection of filoviruses by real-time TaqMan polymerase chain reaction assays. Virol Sin 2012;27:273–7.
- Huang Y, Zhu Y, Yang M, et al. Nucleoprotein-based indirect enzyme-linked immunosorbent assay (indirect ELISA) for detecting antibodies specific to Ebola virus and Marbug virus. Virol Sin 2014;29:372–80.
- Kreuels B, Wichmann D, Emmerich P, et al. A case of severe Ebola virus infection complicated by gram-negative septicemia. N Engl J Med 2014;371:2394–401.
- Alimonti J, Leung A, Jones S, et al. Evaluation of transmission risks associated with in vivo replication of several high containment pathogens in a biosafety level 4 laboratory. Sci Rep 2014;4:5824. doi: 10.1038/srep05824.
- Towner JS, Rollin PE, Bausch DG, et al. Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome. J Virol 2004;78:4330–41.
- Formenty P, Leroy EM, Epelboin A, et al. Detection of Ebola virus in oral fluid specimens during outbreaks of Ebola virus hemorrhagic fever in the Republic of Congo. Clin Infect Dis 2006;42:1521–6.
- Yan L, Zhou J, Zheng Y, et al. Isothermal amplified detection of DNA and RNA. Mol Biosyst 2014;10:970–1003.
- Chang CC, Chen CC, Wei SC, et al. Diagnostic devices for isothermal nucleic acid amplification. Sensors (Basel) 2012;12:8319–37.
- Centers for Disease Control and Prevention (CDC). Review of Human-to-Human Transmission of Ebola Virus. [Online] 12 July 2015 [Updated] 1 October 2015. Available from: http://www.cdc.gov/vhf/ebola/transmission/human-transmission.html [last accessed 10 Oct 2015].
- Centers for Disease Control and Prevention (CDC). Questions and Answers about Ebola, Pets, and Other Animals. [Online] 27 April 2015. Available from: http://www.cdc.gov/vhf/ebola/transmission/qas-pets.html [last accessed 17 Sep 2015].
- World Health Organization (WHO). Frequently asked questions on Ebola virus disease. [Online] Augest 2015. Available from: http://www.who.int/csr/disease/ebola/faq-ebola/en/ [last accessed 17 Sep 2015].
- Dowell SF, Mukunu R, Ksiazek TG, et al. Transmission of Ebola hemorrhagic fever: a study of risk factors in family members, Kikwit, Democratic Republic of the Congo, 1995. Commission de Lutte contre les Epidemies a Kikwit. J Infect Dis 1999;179:S87–91.
- Mossong J, Hens N, Jit M, et al. Social contacts and mixing patterns relevant to the spread of infectious diseases. PLoS Med 2008;5:e74.
- World Health Organization (WHO). Ebola haemorrhagic fever in Zaire, 1976. Bull World Health Organ 1978;56:271–93.
- Centers for Disease Control and Prevention (CDC). Guidance for collection, transport and submission of specimens for Ebola virus testing. [Online] 30 January 2015. Available from: http://www.cdc.gov/vhf/ebola/healthcare-us/laboratories/specimens.html [last accessed 5 Jan 2016].
- Iwen PC, Garrett JL, Gibbs SG, et al. An integrated approach to laboratory testing for patients with Ebola virus disease. Lab Med 2014;45:e146–51.
- Iwen PC, Smith PW, Hewlett AL, et al. Safety considerations in the laboratory testing of specimens suspected or known to contain Ebola virus. Am J Clin Pathol 2015;143:4–5.
- Hill CE, Burd EM, Kraft CS, et al. Laboratory test support for Ebola patients within a high-containment facility. Lab Med 2014;45:e109–11.
- Khan AS, Tshioko FK, Heymann DL, Commission de Lutte contre les Epidemies a Kikwit, et al. The reemergence of Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995. J Infect Dis 1999;179:S76–86
- Mitchell SW, McCormick JB. Physicochemical inactivation of Lassa, Ebola, and Marburg viruses and effect on clinical laboratory analyses. J Clin Microbiol 1984;20:486–9.
- World Health Organization (WHO). Infection prevention and control guidance for care of patients in health-care settings, with focus on Ebola 2014. [Online] December 2014. Available from: http://www.who.int/csr/resources/publications/ebola/filovirus_infection_control/en/ [last accessed 5 Jan 2016].
- Elliott LH, McCormick JB, Johnson KM. Inactivation of Lassa, Marburg, and Ebola viruses by gamma irradiation. J Clin Microbiol 1982;16:704–8.
- World Health Organization (WHO). Categorization and prioritization of drugs for consideration for testing or use in patients infected with Ebola 2015. [Update] 3 July 2015. Available from: http://www.who.int/medicines/ebola-treatment/cat_prioritization_drugs_testing/en/ [last accessed 5 Jan 2016].
- Kugelman JR, Sanchez-Lockhart M, Andersen KG, et al. Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics. MBio 2015;6 : e02227-14.
- Gulland A. Ebola drug trial is to start next month. BMJ 2014;349:g6436.
- Galvani AP, Ndeffo-Mbah ML, Wenzel N, et al. Ebola vaccination: if not now, when? Ann Intern Med 2014;161:749–50.
- Gulland A. Vaccine tests to begin in Ebola countries this year. BMJ 2014;349:g6466.
- Link C Jr, Cohen J. Infectious diseases. The Ebola vaccine underdog. Science 2014;346:534.
- Centers for Disease Control and Prevention (CDC). Case definition for Ebola Virus Disease (EVD). [Online] 16 November 2014. Available from: http://www.cdc.gov/vhf/ebola/healthcare-us/evaluating-patients/case-definition.html [last accessed 17 Sep 2015].
- World Health Organization (WHO). Case definition recommendations for Ebola or Marburg Virus Diseases. [Online] August 2014. Available from: http://www.who.int/csr/resources/publications/ebola/case-definition/en/ [last accessed 17 Sep 2015].
- World Health Organization (WHO). How to safely collect oral swabs from deceased patients suspected to be infected with Ebola. [Online] October 2014. Available from: http://www.who.int/csr/resources/publications/ebola/safely-collect-oral-swabs/en/ [last accessed 17 Sep 2015].
- World Health Organization (WHO). How to safely ship human blood samples from suspected Ebola cases within a country by road, rail and sea. [Online] November 2014. Available from: http://www.who.int/csr/resources/publications/ebola/blood-shipment/en/ [last accessed 17 Sep 2015].
- World Health Organization (WHO). How to safely collect blood samples from persons suspected to be infected with highly infectious blood-borne pathogens (e.g. Ebola). [Online] August 2014. Available from: http://www.who.int/csr/resources/publications/ebola/blood-collect/en/ [last accessed 17 Sep 2015].
- World Health Organization (WHO). Guidance on regulations for the Transport of Infectious Substances 2015-2016. [Online] January 2015. Available from: http://www.who.int/ihr/publications/who_hse_ihr_2015.2/en/ [last accessed 17 Sep 2015].
- McCarthy M. US issues new guidelines for health workers caring for Ebola patients. BMJ 2014;349:g6418.
- Centers for Disease Control and Prevention (CDC). Guidance on personal protective equipment (PPE) to be used by healthcare workers during management of patients with confirmed Ebola or persons under investigation (PUIs) for Ebola who are clinically unstable or have bleeding, vomiting, or diarrhea in U.S. hospitals, including procedures for donning and doffing PPE. [Online] 27 August 2015. Available from: http://www.cdc.gov/vhf/ebola/hcp/procedures-for-ppe.html [last accessed 17 Sep 2015].
- Edmond MB, Diekema DJ, Perencevich EN. Ebola virus disease and the need for new personal protective equipment JAMA 2014;312:2495–6.
- Huang Q, Yao CY, Chen B, et al. Species-specific identification by inhibitor-controlled PCR of ruminant components contaminating industrial crude porcine heparin. Mol Cell Probes 2006;20:250–8.
- Yoshizawa JM, Schafer CA, Schafer JJ, et al. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev 2013;26:781–91.
- Nielsen CF, Kidd S, Sillah AR, et al. Improving burial practices and cemetery management during an Ebola virus disease epidemic – Sierra Leone, 2014. Morb Mortal Wkly Rep 2015;64:20–7.
- Centers for Disease Control and Prevention (CDC). How U.S. clinical laboratories can safely manage specimens from persons under investigation for Ebola virus disease. [Online] 12 November 2014. Available from: http://www.cdc.gov/vhf/ebola/hcp/safe-specimen-management.html [last accessed 23 Mar 2015].
- Centers for Disease Control and Prevention (CDC). Ebola virus disease Information for Healthcare Workers and Settings. [Online] 4 March 2015. Available from: http://www.cdc.gov/vhf/ebola/hcp/index.html [last accessed 10 Sep 2015].
- Centers for Disease Control and Prevention (CDC). Considerations for discharging persons under investigation (PUI) for Ebola Virus Disease (Ebola). [Online] 2 March 2015. Available from: http://www.cdc.gov/vhf/ebola/healthcare-us/evaluating-patients/discharging.html [last accessed 10 Sep 2015].
- Martin P, Laupland KB, Frost EH, et al. Laboratory diagnosis of Ebola virus disease. Intensive Care Med 2015;41:895–8.
- Fletcher TE, Fowler RA, Beeching NJ. Understanding organ dysfunction in Ebola virus disease. Intensive Care Med 2014;40:1936–9.
- Chertow DS, Kleine C, Edwards JK, et al. Ebola virus disease in West Africa-clinical manifestations and management. N Engl J Med 2014;371:2054–7.
- Schieffelin JS, Shaffer JG, Goba A, et al. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med 2014;371:2092–100.
- Kortepeter MG, Bausch DG, Bray M. Basic clinical and laboratory features of filoviral hemorrhagic fever. J Infect Dis 2011;204:S810–16.
- Bausch DG, Towner JS, Dowell SF, et al. Assessment of the risk of Ebola virus transmission from bodily fluids and fomites. J Infect Dis 2007;196:S142–7.
- Geisbert TW, Jahrling PB. Exotic emerging viral diseases: progress and challenges. Nat Med 2004;10:S110–21.
- Mahanty S, Bray M. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect Dis 2004;4:487–98.
- Bustin SA, Benes V, Garson JA, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 2009;55:611–22.
- McElroy AK, Erickson BR, Flietstra TD, et al. Ebola hemorrhagic fever: novel biomarker correlates of clinical outcome. J Infect Dis 2014;210:558–66.
- Wu HM, Fairley JK, Steinberg J, et al. The potential Ebola-infected patient in the ambulatory care setting: preparing for the worst without compromising care. Ann Intern Med 2015;162:66–7.
- Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet 2011;377:849–62.
- Rollin PE, Bausch DG, Sanchez A. Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus. J Infect Dis 2007;196:S364–71.
- Blow JA, Dohm DJ, Negley DL, et al. Virus inactivation by nucleic acid extraction reagents. J Virol Methods 2004;119:195–8.
- Craw P, Balachandran W. Isothermal nucleic acid amplification technologies for point-of-care diagnostics: a critical review. Lab Chip 2012;12:2469–86.
- Drain PK, Hyle EP, Noubary F, et al. Diagnostic point-of-care tests in resource-limited settings. Lancet Infect Dis 2014;14:239–49.
- World Health Organization (WHO). First Antigen Rapid Test for Ebola through Emergency Assessment and Eligible for Procurement. [Online] 2015. Available from: http://www.who.int/medicines/ebola-treatment/1st_antigen_RT_Ebola/en/ [last accessed 17 Sep 2015].
- Food and Drug Administration (FDA). Emergency Use Authorizations. [Online] 8 March 2015. Available from: http://www.fda.gov/MedicalDevices/Safety/EmergencySituations/ucm161496.htm [last accessed 17 Sep 2015].