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Research Article

Leukocyte Alkaline Phosphatase in Disease

Pages 243-278 | Published online: 27 Sep 2008

References

  • Kay H. D. Plasma phosphatase. I. Method of determination. Some properties of the enzyme. J. Biol. Chem. 1930; 89: 235
  • Kay H. D. Plasma phosphatase in osteitis deformans and in other diseases of bone. Brit. J. Exp. Path. 1929; 10: 253
  • Umeno M. Studien über Phosphatase. Part V. Über die Glycerophosphatase der Leucocyten im Blute. Biochem. Z. 1931; 231: 339
  • Iwatsuru R., Nanjo L. Studien über-Phosphatase. Part VIII. Über die Phosphatasenaktivitit des Blutes, SerumsÜber und Harns bei chronischer myeloischer Leukämie. Biochem. Z. 1939; 300: 422
  • Iwatsuru R., Minami Y. Studien über die Phosphatase. Part VII. Die Phosphatase in Blut, Milz, Leber und Nieren bei akuter lymphatischer Leukämie. Biochem. Z. 1934; 268: 394
  • Fiessinger N., Boyer F. Les phosphatases des leucocytes. Enzymologia 1936; 1: 172
  • Takamatsu H. Manshu Igaku Zasshi 1938; 29: 1351
  • Takamatsu H. Histologische und biochemische Studien über die Phosphatase. I. Histochemische Untersuchungsmethodik der Phosphatase und deren Verteilung in verschiedenen Organen und Geweben. Trans. Jap. Path. Soc. 1939; 29: 492
  • Gomori G. Microtechnical demonstration of phosphatase in tissue sections. Proc. Soc. Exp. Biol. Med. 1939; 42: 23
  • Menten M. L., Junge J., Green M. H. A coupling histochemical azo dye test for alkaline phosphatase in the kidney. J. Biol. Chem. 1944; 153: 471
  • Vercauteren R. The intracellular distribution of alkaline and acid phosphatase in leucocytes. Naturwissenschaften 1954; 2: 532
  • Kaplow L. S. A histochemical procedure for localizing and evaluating leukocyte alkaline phosphatase activity in smears of blood and marrow. Blood 1955; 10: 1023
  • Kaplow L. S. Leukocyte alkaline phosphatase cytochemistry: Applications and methods. Ann. N. Y. Acad. Sci. 1968; 155: 911
  • Takeuchi T., Takamatsu H. Histologische und biochemische Studien uber die Phosphatase in tuberkulosen Herden. Trans. Soc. Path. Jap. 1939; 29: 490
  • Gomori G. The distribution of phosphatase in normal organs and tissues. J. Cell. Comp. Physiol. 1941; 17: 71
  • Fell H. B., Danielli J. F. The enzymes of healing wounds. 1. The distribution of alkaline phosphomonoesterase in experimental wounds and burns of rats. Brit. J. Exp. Path. 1943; 24: 196
  • Schaefer H. E., Fischer R., Lehmann E. Die alkalische Leukocytenphosphatase als Unterscheidungsmerkmal für Apodemus sylvaticus und flavicollis. Sonderdruck Z. f. Saugetierkunde 1968; 33: 364
  • Eng Lie-Injo Luan. Alkaline phosphatase activity of the leucocytes in animals. Nature 1964; 204: 191
  • Huser H. J., Olberding B. A. Neutrophil alkaline phosphatase in blood cells of primates. Nature 1967; 214: 1043
  • Jain N. C. Alkaline phosphatase activity in leukocytes of some animal species. Acta Haemat. 1968; 39: 51
  • Kikuchi Y., Phillips M. E. Further studies on serum protein formation by chimeras. 2. Induction of chimerism with sublethal x-irradiation and heterologous antiorgan serum. Proc. Soc. Exp. Med. 1969; 131: 841
  • Santos G. W., Cole L. J. Effects of donor and host lymphoid and myeloid tissue injections in lethally x-irradiated mice treated with rat bone morrow. J. Nat. Cancer Inst. 1958; 21: 279
  • Kikuchi Y., Phillips M. E. Further studies on serum protein formation by chimeras - induction of chimerism with a chemical carcinogen. Cancer Res. 1970; 30: 18
  • Kaplow L. S. Alkaline phosphatase activity in peripheral blood lymphocytes. Arch. Path. 1969; 88: 69
  • Kaplow L. S. Cytochemistry of leukocyte alkaline phosphatase. Use of complex naphthol AS-phosphates in azo dye coupling techniques. Amer. J. Clin. Path. 1963; 39: 439
  • Tanaka K. R., Valentine W. N., Fredricks R. E. Diseases or clinical conditions associated with low leukocyte alkaline phosphatase. New Eng. J. Med. 1960; 262: 912
  • Ozsoylu S. Leukocyte alkaline phosphatase activity in rickets due to vitamin D deficiency. New Eng. J. Med. 1969; 280: 1221
  • Rosner F., Lee S. L. Endocrine relationships of leukocyte alkaline phosphatase. Blood 1965; 25: 356
  • Tosnonaga M., Ichmaru M., Toyoda S., Watanabe B. Studies on catalase and alkaline phosphatase of leukemic cells. Proc. VIIIth Int. Cong. Haematol. (Tokyo) 1960; 2: 766
  • Meislin A. G., Lee S. L., Wasserman L. R. Leukocyte alkaline phosphatase activity in hematopoietic disorders. A correlative study by biochemical and cytochemical techniques. Cancer 1959; 12: 760
  • Valentine W. N., Beck W. S. Biochemical studies on leucocytes. I. Phosphatase activity in health, leucocytosis, and myelocytic leucemia. J. Lab. Clin. Med. 1951; 38: 39
  • Wachstein M. Alkaline phosphatase activity in normal and abnormal human blood and bone marrow cells. J. Lab. Clin. Med. 1946; 31: 1
  • Anstey L., Kemp N. H., Stafford J. L., Tanner R. K. Leucocyte alkaline phosphatase activity in polycythaemia rubra vera. Brit. J. Haemat. 1963; 9: 91
  • Hayhoe F. G. J., Quaglino D. Cytochemical demonstration and measurement of leucocyte alkaline phosphatase activity in normal and pathological states by a modified azo-dye coupling technique. Brit. J. Haemat. 1958; 4: 375
  • Gordon S., Hunter E. Re-evaluation of the leucocyte alkaline phosphatase test. Med. J. Aust. 1965; 2: 13
  • McCoy E. E., Park J., England J. A fluorometric assay and properties of leucocyte alkaline phosphatase. Clin. Chim. Acta. 1965; 12: 453
  • Wyllie R. G. A modified method for staining neutrophil alkaline phosphatase and normal levels. Med. J. Aust. 1964; 1: 876
  • Abul-Fadl Y., Scott R. B. Glycogen in human peripheral blood leukocytes. III. Effect of female hormones. Scand. J. Haemat. 1969; 6: 262
  • Uberla K., Tilling W., Grätzel C. Vergleich zweier Bestimmungsmethoden der alkalischen Leukozytenphosphatase. Blut 1967; 15: 13
  • Polishuk W. Z., Zuckerman H., Diamant Y. Alkaline phosphatase activity in leukocytes during menstrual cycle. Fertil. Steril. 1968; 19: 901
  • Borel C., Frei J., Vannotti A. Etude enzymatique directe au niveau du leucocyte. Helv. Physiol. Pharmacol. Acta 1958; 16: C53
  • Müller D. Zur Frage der endokrinen Beeinflussung der alkalischen Leukozytenphosphatase. Blut 1967; 14: 273
  • Plenert W. Cytochemische Studie über das Verhalten der alkalischen Phosphatase der Leukocyten beim Neugeborenen. Folia Haemat. 1958; 75(378)196
  • Bertolotti E., Lojodice G., Quazza G. F. La forfatasi alcaline nei granulociti neutrofili. Suo comportamento nelle prime epoche della vita. (c) Studio nei lattanti nati a termine. Minerva Pediat. 1964; 16: 1
  • Schwier M. Zur Verhaltensweise der alkalischen Leukocytenphosphatase im Kindesalter unter physiologischen und pathologischen Bedingungen. Schweiz. Med. Wschr. 1967; 97: 654
  • O'Kell R. T., Axon L. L. Leukocyte alkaline phosphatase in the newborn infant. Amer. J. Obstet. Gynec. 1965; 93: 1181
  • Eng Lie-Injo Luan, Govindasamy S. Leucocyte alkaline phosphatase, leucocyte count and haemoglobin level in Malayan new-borns and young infants. Med. J. Malays 1965; 19: 263
  • Wolf P. L., Silberberg B., Albert S., Horwitz J., et al. Histochemical similarities between newborn and leukaemic myeloid cells and their possible significance. J. Clin. Path. 1969; 22: 458
  • Bini R., Brandigi L. La fosfatasi alcalina nei granulociti neutrofili. (Studio comparativo nel neonato a termine e nell'immaturo nei primi giorni di vita). Riv. Clin. Pediat. 1966; 77: 225
  • Toyoda S. Studies of characteristics of leukocyte from a pediatric perspective. II. Studies on neutrophilic alkaline phosphatase activity. Hiroshima J. Med. 1968; 17: 337
  • Sramkova L., Staninec M., Vacek Z., Zeman L. The effect of vaccination against measles on the white blood picture and the alkaline phosphatase activity of neutrophil leukocytes. Acta Univ. Carol (Med) (Praha). 1967; 13: 223
  • O'Kell R. T. Leukocyte alkaline phosphatase in the infant. Ann. N. Y. Acad. Sci. 1968; 155: 980
  • Bertolotti E., Lojodice G., Quazza G. F., Brovarone E. La fosfatasi alcalina nei granulociti neutrofili: valori normali nelle varie epoche della vita fino all'eta senile. Minerva Pediat. 1965; 17: 915
  • Leonard B. J. The inheritance of white-cell alkaline phosphatase: Its significance in health and disease. Brit. J. Haemat. 1967; 13: 807
  • Rosner F., Lee S. L., Schultz F. S., Gorfien P. C. The regulation of leukocyte alkaline phosphatase. Ann. N. Y. Acad. Sci. 1968; 155: 902
  • Ray P. K., Pinkerton P. H. Leukocyte alkaline phosphatase - effect of age and sex. Acta Haemat. 1969; 42: 18
  • Stevenson T. D., Sherman W. R. The effect of estrogen and progesterone on leukocyte alkaline phosphatase. Amer. J. Clin Path. 1967; 47: 379, (Abstract - annual meeting of the Amer. Soc. Clin. Path., 1966.).
  • Schubert L., Chiara F. A new histochemical method for study of the behavior of leukocytic alkaline phosphatase in normal pregnancy and puerperium. Ann. Ostet. Ginec. 1966; 88: 845
  • Sammour M. B., Hilal S. O. Alkaline phosphatase activity of polymorphonuclear leukocytes in relation to oral contraceptives. Amer. J. Obstet. Gynec. 1969; 103: 823
  • Pritchard J. A. Leukocyte phosphatase activity in pregnancy. J. Lab. Clin. Med. 1957; 50: 432
  • Tarnawski A., Wajdowicz A. Activity of alkaline phosphatase in granulocytes after physical exertion. Przegl. Lek. 1969; 25: 618
  • Beisel W. R. Neutrophile alkaline phosphatase changes in tolaremia, sandfly fever, Q fever and noninfectious fevers. Blood 1967; 29: 257
  • Plum C. M. Alkaline phosphatase in cells of normal and pathological bone marrow compared with peripheral blood cells. Nord. Med. 1950; 43: 69
  • Beck W. S., Valentine W. N. Biochemical studies on leucocytes. II. Phosphatase activity in chronic lymphatic leucemia, acute leucemia and miscellaneous hematologic conditions. J. Lab. Clin. Med. 1951; 38: 245
  • Valentine W. N., Beck W. S., Follette J. H., Mills H., et al. Biochemical studies in chronic myelocytic leukemia, polycythemia vera and other idiopathic myeloproliferative disorders. Blood 1952; 7: 959
  • Valentine W. N., Follette J. H., Hardin E. B., Beck W. S., et al. Studies on leukocyte alkaline phosphatase activity: relation to “stress” and pituitary-adrenal activity. J. Lab. Clin. Med. 1954; 44: 219
  • Valentine W. N., Follette J. H., Solomon D. H., Reynolds J. The relationship of leukocyte alkaline phosphatase to “stress”, to ACTH, and to adrenal 17-OH-corticosteroids. J. Lab. Clin. Med. 1957; 49: 723
  • Moloney W. C., Lange R. D. Leukemia in atomic bomb survivors. II. Observations on early phases of leukemia. Blood 1954; 9: 663
  • Wiltshaw E., Moloney W. C. Histochemical and biochemical studies on leukocyte alkaline phosphatase activity. Blood 1955; 10: 1120
  • Wiltshaw E., Moloney W. C. Studies on various factors influencing leukocyte alkaline phosphatase activity. J. Lab. Clin. Med. 1956; 41: 691
  • Williams M. J., Mendel J. L. Polycythemia vera terminating with myeloblastic leukemia. Correlation of morphologic findings with leukocytic phosphatase studies. Blood 1954; 9: 189
  • Williams M. J., Mendel J. L. Studies on the alkaline and acid phosphatase content of leukocytes in various hematological disorders. Texas Rep. Biol. Med. 1954; 12: 429
  • McCall C. E., Katayama S., Cotran R. S., Finland M. Lysosomal and ultrastructural changes in human “toxic” neutrophils during bacterial infection. J. Exp. Med. 1969; 129: 267
  • Bery G., Roorand U., Witte S., Götz H., et al. Über die Beziehungen zwischen neutrophilen Leukozyten und Serumglobulinfraktionen. Clin. Chim. Acta. 1965; 12: 282
  • Sakamoto S. Histochemical studies on leukocyte alkaline phosphatase activity with special reference to various types of hemolytic disorders. Tohoku J. Exp. Med. 1966; 89: 387
  • Antonioli J. A., Baer A., Vannotti A. Les phosphatases leucocytaires alcaline et acide: Variations pathologiques, regulation humorale et rapports avec les phosphatases plasmatiques. Acta Haemat. 1965; 34: 129
  • Bini R., Duvina P. L. Changes of leukocytic alkaline phosphatase in acidosis states. Riv. Clin. Pediat. 1967; 78: 898
  • Hook E. B., Engel R. R. Leucocyte life-span, leucocyte alkaline phosphatase, and the 21st chromosome. Lancet 1964; 1: 112
  • Rosen R. B., Nishiyama H. Leukocyte alkaline phosphatase in chronic granulocytic leukemia of childhood. Ann. N.Y. Acad. Sci. 1968; 155: 992
  • Tsukada T. Cytochemical studies on alkaline phosphatase activity in neutrophilic leukocytes. II. Mechanisms of the changes in the activity in various physiologic and pathologic conditions. J. Jap. Soc. Interm. Med. 1962; 51: 900
  • Weber W. W., Mittwoch U., Delhanty J. D. A. Leucocyte alkaline phosphatase in Klinefelter's syndrome. J. Med. Genet. 1965; 2: 112
  • Fliedner T. M., Cronkite E. P., Killman S. A., Bond V. P. Granulocytopoiesis. II. Emergence and pattern of labeling of neutrophilic granulocytes in humans. Blood 1964; 24: 683
  • Trubowitz S., Moschides E., Feldman D. Alkaline phosphatase activity of the polymorphonuclear leukocyte in rapidly induced leukopenia and leukocytosis. J. Lab. Clin. Med. 1961; 57: 747
  • Merker H. The significance of cytochemical and cytogenetic findings in chronic granulocytic leukemia and related diseases. Current Research in Leukemia, F. G.H. Hayhoe. Cambridge University Press, London 1965; 1
  • Gomori G. Calcification and phosphatase. Amer. J. Path. 1943; 19: 197
  • Wyllie R. G. Neutrophil alkaline phosphatase: Response to acute inflammation. Aust. Ann. Med. 1962; 11: 118
  • Kaplow L. S., Beck R. E. Leukocyte alkaline phosphatase response to surgical stress. Surg. Gynec. Obstet. 1964; 119: 97
  • Plenert W. Studien zur Zytochemie der Leukozytenphosphatasen im Kindesalter. II. Der Einfluss von Operation und infekt auf die alkalische Granulozytenphosphatase. Folia Haemat. 1962; 79: 288
  • Shubich M. G., Avakimyan V. A. The value of cytochemical determination of the leukocyte alkaline phosphatase in surgical clinic. Vestn. Khir. Grekov. 1966; 96: 41
  • Pertseva T. N. The importance of a cytochemical study of acid and alkaline phosphatase in evaluating the postoperative course of neurosurgical patients. Vop. Neirokhir. 1969; 33: 45
  • Hattori K. Studies on leukocyte alkaline phosphatase activity. 2. Histochemical study. Acta Haemat. Jap. 1959; 22: 925
  • Nagoev B. S. Cytochemical studies of the alkaline phosphatase activity of leukocytes in various infectious intestinal diseases. Sovet. Med. 1968; 31: 52
  • Sramkova L., Lasovska J., Seidler L. Alkaline phosphatase of leukocytes in bacterial intestinal infections. Med. Klin. 1968; 63: 1674
  • Nagoev B. S., Primachenko N. B., Schubich M. G. On the relationship between the alkaline phosphatase activity of neutrophil leukocytes and their capacity for phagocytosis in salmonella infections. Zh. Mikrobiol. 1969; 46: 145
  • Dosseva I. M. Phosphatase activity of the white blood cells in patients with pulmonary tuberculosis. J. Suvremenna Med. 1957; 8: 70
  • Godes Yu. E. Alkaline phosphatase of leukocytes as a criterion of pulmonary tuberculosis activity. Klin. Med. Moskva. 1966; 44: 59
  • Lopes-Cardozo P. L., Bokms L., Doesburg N. Die klinische Handhabung des alkalischen Phosphatase-Index für Leukozyten. Zyto-und Histochemie in der Hamatologie, Neiuntes Freiburger Symposion, H. Merker. Springer-Verlag, Berlin 1963; 313
  • Bertolotti E., Quazza G. F. La fosfatasi alcalina leucocitaria. Minerva Pediat. 1963; 15: 602
  • Caban J., Okulski J., Mirecka J., Lisiewica J. Activity of alkaline phosphatase in neutrophilic granulocytes in patients with tetanus. Pol. Tyg. Lek. 1969; 24: 676
  • Caban J., Okulski J., Mirecka J., Lisiewicz J. Activity of alkaline phosphatase of blood neutrophils in patients with tetanus. Pol. Med. J. 1970; 9: 433
  • Szegö V., Szentkiralyi F., Makai M., Fremda E. Diagnostic value of leukocyte alkaline phosphatase in infectious diseases. Med. Intern. Bucur 1966; 18: 743
  • Hausser E., Stroun J. Leukocyte alkaline phosphatase in virus diseases. Schweiz. Med. Wschr. 1962; 92: 1334
  • Par A., Barna K. Study of alkaline phosphatase activity of granulocytes in hematologic and infectious diseases. Orv. Hetil. 1969; 110: 960
  • Dieska D., Gocarova K. Alkaline phosphatase of neutrophilic leucocytes in the diagnosis of liver and biliary tract diseases. Bratisl. Lek. Listy 1967; 48: 175
  • Kolesnikova M. B. Indices of alkaline phosphatase and succinodehydrogenase activity in the leukocytes of children suffering from pneumonia. Vop. Okhr. Materin. Detz. 1967; 12: 20
  • Szego V., Szentkiralyi E., Kelemen L., Makai M. Diagnostic value of leukocytic alkaline phosphatase in acute neuro-infections. Neurologia Bucur 1967; 12: 227
  • Hausser E., Stroun J. La phosphatase alcaline leucocytaire au cours des affections virales. J. Suisse Med. 1962; 42: 1334
  • Burdea M., Wexler T., Rusu O., Polack N. Value of the histochemical leukocytic alkaline phosphatase (LAP) test in the diagnosis of acute pneumopathies in children. Pediatria Bucur 1967; 16: 159
  • Sramkova L., Prochazkova E. Alkaline phosphatase in neutrophilic leukocytes in infectious diseases. Schweiz. Med. Wschr. 1968; 98: 1325
  • Sowa J. M., Townes A. S., Bianchin J. R. Alkaline phosphatase activity in synovial fluid neutrophilic leukocytes. Arth. Rheum. 1968; 11: 841
  • Loschiavo F., Neri A., Gallo D. Cytochemical study of peroxidases and alkaline phosphatases in bone-marrow and peripheral blood elements in ancylostomiasis. Haematologica 1966; 51: 409
  • Sirola I., Sirola K. A histochemical study of alkaline phosphatase in the leukocytes of blood and bone marrow in various diseases. Acta Haemat. 1957; 18: 313
  • Wulff H. R., Riis P. Cytokemisk pavisning af basiske fosfataser I leukocytter. Et diagnostisk hjaelpemiddel. Ugeskr. Laeg. 1961; 123: 1303
  • Godes Yu. E. Leukocyte alkaline phosphatase activity in tuberculosis. Klin. Med. Moskva 1969; 47: 88
  • Tsigel'nik A. Ya., Godes Yu. E. Clinical value of determining leukocyte alkaline phosphatase activity in pulmonary tuberculosis. Sovet. Med. 1967; 30: 23
  • Godes Yu. E. Cytochemical indices as criteria of the reactivity of patients with tuberculosis. Probl. Tuberk. 1968; 46: 76
  • Kochnova I. E., Fradkin V. A., Razumovskaya V. F., Genkina V. N. Lipids, acid and alkaline phosphatases of neutrophils in the blood in determining the activeness of tuberculosis. Sovet. Med. 1967; 30: 17
  • Siering H., Krause Ch. Leukocyte alkaline phosphatase and tuberculosis. Med. Klin. 1966; 361: 251
  • Weissel M., Mühlberg H. Das Verhalten der alkalischen Leukozytenphosphatase der neutrophilen Granulozyten bei der Tuberkulose. Z. Tuberk. 1964; 121: 73
  • Hughes J. T., Johnstone R. M., Scott A. C., Stewart P. D. Leukaemoid reactions in disseminated tuberculosis. J. Clin. Path. 1959; 12: 307
  • Withers K. L. Leukaemoid reactions in disseminated non-reactive tuberculosis: A review of the literature with report of a case. Med. J. Aust. 1964; 2: 142
  • Akopova V. L. Differential diagnosis of jaundice. Vrach. Delo. 1967; 3: 13
  • Akopova V. L. Clinical value of cytochemical study of alkaline phosphatase of the leukemia in the differential diagnosis of jaundice. Ter. Arkh. 1966; 38: 51
  • Dangoumau J., Beraud C., Castets P. H., Traissac F. J. Behavior of leukocyte alkaline phosphatase in hepato-biliary diseases. Rev. Etud. Franc. Clin. Biol. 1967; 12: 367
  • Ferdinandy K. Study of granulocytic alkaline phosphatase activity in the differential diagnosis of viral hepatitis. Orv. Hetil. 1968; 109: 351
  • Joshi K. R., Gupta D. P. Evaluation of leucocytic alkaline phosphatase activity as a pregnancy test. Indian J. Path. Bact. 1967; 10: 138
  • Dieska D., Gocarova K. The diagnostic significance of the estimation of alkaline phosphatase activity in neutrophil leucocytes Shornik prac z III. vedeckij konferencie ILF. Bratislava 1967; 6-9: 107
  • Antokhina L. I. Diagnostic value of determining the alkaline phosphatase of leukocytes and blood serum in certain diseases of the digestive apparatus. Sovet. Med. 1970; 33: 91
  • Pexa H., Neumayr A. The diagnostic significance of leucocytic alkaline phosphatase in hepatobiliary diseases. Acta Hepatosplen. Stuttgart 1967; 14: 348
  • Sramkova L., Vanista J., Masek K. Alkaline phosphatase in leukocytes and infectious hepatitis. Influence of corticoid treatment and differentiation from other affections of the liver and biliary pathways. Cas. Lek. Cesk. 1966; 105: 234
  • Kusch F. Alkaline phosphatase activity in virus hepatitis. Pol. Arch. Med. Wewnet. 1970; 44: 25
  • Theron J. J., Coetzee V., Pretorius P. J. A histochemical investigation of the leucocytes in Kwashiorkor. J. Clin. Path. 1959; 12: 454
  • Tejada C., Argueta V., Sanchez M., Albertazzi C. Phagocytic and alkaline phosphatase activity of leukocytes in Kwashiorkor. J. Pediat. 1964; 64: 753
  • Harer W. B., Jr., Quigley H. J. Alkaline phosphatase activity in granular leukocytes as a test for early pregnancy. Obstet. Gynec. 1961; 17: 238
  • Stubblefield C. Y. Leukocyte alkaline phosphatase activity test for pregnancy. Ann. N.Y. Acad. Sci. 1968; 155: 972
  • Russo A., Macchioni B. Value of alkaline phosphatase in diagnosis of ectopic pregnancy. Minerva Ginec. 1962; 14: 1138
  • Beal R. W., Read W. M. F., Turvey P. A. Neutrophil alkaline phosphatase in pregnancy. J. Clin. Path. 1967; 20: 749
  • Chowdhury S. R., Halder K., Chaudhuri N. Alkaline phosphatase activity during pregnancy and puerperium in Indian women. Indian J. Med. Sci. 1965; 19: 493
  • Goldstein D. P. Neutrophil alkaline phosphatase activity in patients with choriocarcinoma and related trophoblastic tumors, undelivered hydatidiform mole, and in normal pregnancy. Amer. J. Obstet. Gynec. 1965; 92: 1014
  • Goldstein D. P. Studies on leukocyte alkaline phosphatase activity: Relation to female sex hormones and gonadotropins. Obstet. Gynec. 1965; 25: 413
  • Polishuk W. Z., Diamant Y. Z., Zuckerman H., Sadovsky E. Leukocyte alkaline phosphatase in pregnancy and puerperium. Amer. J. Obstet. Gynec. 1970; 107: 604
  • Heinrichs W. L. The neutrophil alkaline phosphatase test in pregnancy. Harper Hosp. Bull. 1962; 20: 107
  • Haering M. Das Verhalten der alkalischen Leukozytenphosphatase (ALP) in der Schwangershaft, unter der Geburt und im Wochenbett. Z. Geburtsh. Gynaek. 1964; 162: 132
  • Bauer-Sic P. Signifikante Veranderung des alkalischen Leukozytenphosphatase-Index während des menstruellen Zyklus. Acta Endocr. 1966; 52: 130
  • Stevenson T. D., Sherman W. R., von Haam E. The effect of estrogen and progesterone on leukocyte alkaline phosphatase activity. Fed. Proc. 1967; 26: 789, Abstr. No. 2971
  • Macaraeg P. V. J., Jr., Connell E., Bianchine J. R. Neutrophil alkaline phosphatase activity. Arch. Intern. Med. 1968; 122: 412
  • Lyons R. B., Weaver D. D., Beck J. H. Isozymes of human leukocyte alkaline phosphatase. Ann. N. Y. Acad. Sci. 1968; 155: 948
  • Diamant Y. Z., Thilo E., Sadovsky E., Polishuk W. Z. Leukocyte alkaline phosphatase in pregnancy comparison with placental phosphatase activity. Clin. Chim. Acta 1970; 29: 395
  • Schubert L. Research on the behavior of leukocytic alkaline phosphatase activity in some pathological states of pregnancy. Ann. Ostet. Ginec. 1966; 88: 871
  • Berretta L. R. Sul valore semeiologico della fosfatasi alcaline leucocitaria nella diagnosi di gravidanza ectopica. Minerva Ginec. 1962; 14: 1138
  • Silva A. R., Jr., Corbit J. D., Jr. Rapid laboratory test for differential diagnosis of ectopic pregnancy. Obstet. Gynec. 1961; 18: 283
  • Chang I. W. Clinical application of the neutrophil alkaline phosphatase test. Amer. J. Obstet. Gynec. 1963; 86: 903
  • Zuckerman H., Sadovsky E., Diamant Y. Z., Polishuk W. Z. Monitoring of leukocyte alkaline phosphatase activity in pregnancy. Israel J. Med. Sci. 1969; 5: 1159
  • Diamant Y. Z., Zuckerman H., Sadovsky E., Polishuk W. Z. Leukocyte alkaline phosphatase in cases of bleeding in first half of pregnancy. Amer. J. Obstet. Gynec. 1970; 106: 872
  • Climie A. R. W., Heinrichs W. L., Foster I. J. Neutrophilic alkaline phosphatase test. A review with emphasis on findings in pregnancy. Techn. Bull. Regist. Med. Techn. 1962; 32: 95
  • Krawczyk B., Pertynski T., Torbus B., Kuchowicz W., et al. Patterns of alkaline phosphatase in leukocytes in genital neoplasms. Wiad. Lek. 1968; 21: 1301
  • Schubert L. Comportamento della fosfatasi alcaline leucocitaria in pazienti affette da neoplasie ginecologiche. Ann. Ostet. Ginec. 1966; 88: 957
  • Levine B., Mandell G., Lipschutz D., Bernstein J. Leukocyte alkaline phosphatase in gynecologic cancer. Amer. J. Obstet. Gynec. 1966; 95: 692
  • Levine B. Functional bleeding - a metabolic disease?. J. Michigan Med. Soc. 1961; 60: 361
  • Levine B. Sex steroids, alkaline phosphatase, and endometrial carcinoma. Obstet. Gynec. 1963; 22: 563
  • Sramková L., Kouba K., Bendova N. Alkaline phosphatase in neutrophil leukocytes of patients with infectious mononucleosis and the effect of corticosteroid therapy. Blood 1965; 26: 479
  • Kemp J. A., Herndon J. W., Wright C. S. Vacillations in leukocytic alkaline phosphatase. Southern Med. J. 1962; 55: 281
  • Ackerman G. A. Substituted naphthol AS phosphate derivatives for the localization of leukocyte alkaline phosphatase activity. Lab. Invest. 1962; 11: 563
  • Baxter A. A critical study of a histochemical stain for evaluating leukocyte alkaline phosphatase activity in smears of human peripheral blood. Canad. J. Med. 1963; 25: 54
  • Tsukada T. Cytochemical studies on alkaline phosphatase activity of neutrophitic leukocytes. I. Variations of the activity in various pathologic conditions, with special reference to the hematologic disorders. J. Jap. Soc. Intern. Med. 1962; 51: 890
  • Schmalzi F., Ciresa M., Braunsteiner H. Zur Zytochemie der Drüsenfieberzellen. Acta Haemat. 1968; 39: 257
  • Balashova T. B., Kazarin V. S., Sukhanova I. A. The activity of alkaline phosphatase of neutrophilic leukocytes as an auxiliary test in the differential diagnosis of angina and infectious mononucleosis. Vop. Okhr. Materin. Detz. 1966; 11: 30
  • Radojicic B., Pekic B., Miolin A., Plamenac J. Klinicka vrednost odredivanja aktivnosti alkalne fosfataze u leukocitima. Vojnosanit. Pregl. 1967; 24: 336
  • Knudtson K. P., Evanger A. E., Stevens A. R., Jr. Standardization of the leukocyte alkaline phosphatase test. II. Report of clinical studies. Amer. J. Clin. Path. 1964; 42: 121
  • Hoffman G. C., Lucich V. J. The clinical application of a modified azo-dye technic for the determination of alkaline phosphatase activity in neutrophils. Cleveland Clin. Quart. 1960; 27: 146
  • Editorial. Leucocyte alkaline phosphatase and Hodgkin's disease. Brit. Med. J. 1968; 3: 390
  • Bennett J. M., Nathanson L., Rutenberg A. M. Significance of leukocyte alkaline phosphatase in Hodgkin's disease. Arch. Intern. Med. 1968; 121: 338
  • Lacher M. J., Ley A. B. The value of leukocyte alkaline phosphatase determinations in the malignant lymphomas. Cancer 1964; 17: 402
  • Keiser G., Alsleben U. Alkalische Leukocytenphosphatase und Blutkrankheiten (differentialdiagnostische und prognostische Bedeutung). Schweiz. Med. Wschr. 1963; 93: 1
  • Marmont A., Correale L. La determinazione della fosfatasi alcalina leucocitaria nella diagnostica e nello studio delle leucopatie. Boll. Soc. Ital. Haemat. 1961; 9: 83
  • Alsleben U. Das Verhalten der alkalischen Leukozytenphosphatase (ALP) bei verschiedenen Krankheiten und ihre differentialdiagnostische Bedeutung. Ther. Umsch. 1961; 18: 52
  • Tognella S., Bignotti G., Grifoni V. Studio della fosfatasi alcalina leucocitaria nelle emoblastosi. Haemat. Lat. 1965; 8: 247
  • Flury R., Wegmann T. Das Verhalten der alkalischen Leukocytenphosphatase beim Morbus Hodgkin. Schweiz. Med. Wschr. 1964; 94: 958
  • Schumacher K. Die Bedeutung der alkalischen Leukozytenphosphatase fur Differentialdiagnose und Prognose maligner Hämoblastosen. Med. Welt. 1964; 9: 415
  • Gatti A., Giustina G., Libro D., Maggi N. L'astivita fosfatasica ulcalina dei globuli bianchi (LPA in corso di emoblastosi. Progr. Med. Napoli 1961; 17: 365
  • Bargaoui M., Emberger J. M., Navarro M. La phosphatase alcaline leucocytaire, Son interet pour le diagnostic hematologique. Arch. Inst. Pasteur Tunis 1965; 3–4: 371
  • Merker H. Cytochemische Beobachtugen bei Erythropathien unter besonderer Berucksichtigung von Glykogen und freiem Eisen. Schweiz. Med. Wschr. 1961; 91: 1209
  • Beal R. W., Kronenberg H., Firkin B. G. The syndrome of paroxysmal nocturnal hemoglobinuria. Amer. J. Med. 1964; 37: 899
  • Sforza M. B. Fosfatasa alcalina leucocitaria y cultivos de linfocitos en aplasias y hemoglobinurias paroxisticas nocturnas. Medicina 1970; 30: 79
  • Lewis S. M., Dacie J. V. Neutrophil (leucocyte) alkaline phosphatase in paroxysmal nocturnal haemoglobinuria. Brit. J. Haemat. 1965; 11: 549
  • Rieder H., Zawadzki Z. A. Ueber alkalische Leukozytenphosphatase bei Blut- und Leberkrankheiten. Wien. Klin. Wschr. 1961; 73: 476
  • Hayhoe F. G. J., Quaglino D. Refractory sideroblastic anaemia and erythraemic myelosis: Possible relationship and cytochemical observations. Brit. J. Haemat. 1960; 6: 381
  • Merker H. The differentiation between anaemia sideroblastica refractoria and erythremic myelosis by cytochemical methods. Proc. 9th Congr. Europ. Soc. Haemat., Lisbon, 1963; 290
  • Weissel M. Verhalten der alkalischen Leukozytenphosphatase bei Panzytopenien. Folia Haemat. Leipzig 1966; 85: 245
  • Plum C. M. Die alkalische Phosphatase in den Zellen des normalen und pathologischen Knochenmarkes und des peripheren Blutes. Acta Haemat. 1950; 4: 73
  • Weissel M. Die alkalische Leukozytenphosphatase. II. Das Verhalten der alkalischen Leukozytenphosphatase bei verschiedenen Krankheiten. Z. Ges. Inn. Med. 1963; 18: 577
  • Mitus W. J., Bergna L. J., Mednicoff I. B., Dameshek W. Alkaline phosphatase of mature neutrophils in chronic forms of the myeloproliferative syndrome. Amer. J. Clin. Path. 1958; 30: 285
  • Brozovic-Vasic M., Ruvidic R. Leukocyte alkaline phosphatase in chronic granulocytic leukaemia. Acta Med. Iugosl. 1964; 18: 157
  • Toyoda S. Studies on leukocyte alkaline phosphatase. J. Kyushu. Hemat. Soc. 1960; 10: 565
  • Nakatsui T. Studies on neutrophile alkaline phosphatase in chronic granulocytic leukemia - on the mechanism of its low value. J. Kyushu Hemat. Soc. 1966; 16: 133
  • Cohen S. M. Chronic myelogenous leukemia with myelofibrosis. Arch. Intern. Med. 1967; 119: 620
  • Kemp N. H., Stafford J. L., Tanner R. Chromosome studies during early and terminal chronic myeloid leukaemia. Brit. Med. J. 1964; 1: 1010
  • Block J. B., Carbone P. P., Oppenheim J. J., Frei E., III. The effect of treatment in patients with chronic myelogenous leukemia. Ann. Intern. Med. 1963; 59: 629
  • Xefteris E., Mitus W. J., Mednicoff I. B., Dameshek W. Leukocytic alkaline phosphatase in busulfan induced remissions of chronic granulocytic leukemia. Blood 1961; 18: 202
  • Krauss S. The Philadelphia chromosome and leukocyte alkaline phosphatase in chronic myelocytic leukemia and related disorders. Ann. N.Y. Acad. Sci. 1968; 155: 983
  • Ezdinli E. Z., Sokal J. E., Crosswhite L., Sandberg A. A. Philadelphia-chromosme-positive and -negative chronic myelocytic leukemia. Ann. Intern. Med. 1970; 72: 175
  • Alter A. A., Lee S. L., Pourfar M., Dobkin G. Studies of leukocyte alkaline phosphatase in mongolism: A possible chromosome marker. Blood 1963; 22: 165
  • Trubowitz S., Kirman D., Masek B. The leucocyte alkaline phosphatase in mongolism. Lancet 1962; 2: 486
  • Beutler E., Goldenburg E. W., Ohno S., Yettra M. Chromosome-21 and paroxysmal nocturnal hemoglobinuria. Blood 1964; 24: 160
  • Conrad M. E., Rappaport H., Crosby W. H. Chronic granulocytic leukemia in the aged. Arch. Intern Med. 1965; 116: 765
  • Hardisty R. M., Speed D. E., Till M. Granulocytic leukaemia in childhood. Brit. J. Haemat. 1964; 10: 551
  • Reisman L. E., Trujillo J. M. Chronic granulocytic leukemia of childhood. J. Pediat. 1963; 62: 710
  • Holton C. P., Johnson W. W. Chronic myelocytic leukemia in infant siblings. J. Pediat. 1968; 72: 377
  • Randall D. L., Reiquam C. W., Githens J. H., Robinson A. Familial myeloproliferative disease. Amer. J. Dis. Child. 1965; 110: 479
  • Jacobs E. M., Luce J. K., Cailleau R. Chromosome abnormalities in human cancer. Report of a patient with chronic myelocytic leukemia and his nonleukemic monozygotic twin. Cancer 1966; 19: 869
  • Skaff G., Lowman J. T., Brunning R., Krivit W. Vitamin B12 studies in myelogenous leukemia of childhood. J. Pediat. 1966; 68: 890
  • Zittoun J., Zittoun R., Guernet M., Bilski-Pasquier G., et al. L'hypervitaminemie B12 dans les leucemies et syndromes myeloproliferatifs. Rev. Franc, Etud. Clin. Biol. 1968; 13: 684
  • Bellotti R., Quazza G. F., Verri B., Lester A., et al. Studio del comportamento della fosfatasi alcalina dei ganulociti neutrofili in diversi momenti di un prolungato periodo di incubazione degli strisci nella sostanza colorante. Minerva Pediat. 1966; 18: 851
  • Kenny J. J., Moloney W. C. Leukocytic alkaline phosphatase, Behavior during prolonged incubation and infection in normal and leukemic leukocytes. Blood 1957; 12: 295
  • Perillie P. E., Finch S. C. Alkaline phosphatase activity of exudative leukocytes in acute leukemia. Blood 1961; 18: 572
  • Rebuck J. W., Crowley J. H. A method for studying leukocytic functions in vivo. Ann. N.Y. Acad. Sci. 1955; 59: 757
  • Lorenzi T. F. Citoquimica das células do sangue como meio de avaliacao e seguimento dos estados leucemicos. J. Bras. Med. 1965; 9: 1227
  • Tanzer J., Harel P., Boiron M., Bernard J. Cytochemical and cytogenetic findings in a case of chronic neutrophilic leukaemia of mature cell type. Lancet 1964; 1: 387
  • Rubin H. Chronic neutrophilic leukemia. Ann. Intern. Med. 1966; 65: 93
  • Kenis Y., Koulischer L. Etude clinique et cytogenetique de 21 patients atteints de leucémie myeloide chronique. Europ. J. Cancer 1967; 3: 83
  • Gingold N., Oproiu C. D., Comanescu N. Cytochemical and cytogenetic findings in chronic neutrophilic leukaemia of mature cell type. Lancet 1964; ii: 1123
  • Gruenwald H., Kiossoglou K. A., Mitus W. J., Dameshek W. Philadelphia chromosome in eosinophilic leukemia. Amer. J. Med. 1965; 39: 1003
  • Kiossoglou K. A., Mitus W. J., Dameshek W. Cytogenetic studies in the chronic myeloproliferative syndrome. Blood 1966; 28: 241
  • Bottomley R. H., Lovig C. A., Holt R., Griffin M. J. Comparison of alkaline phosphatase from human normal and leukemic leukocytes. Cancer Res. 1969; 29: 1866
  • Mitus W. J., Mednicoff I. B., Dameshek W. Alkaline phosphatase of mature neutrophils in various “polycythemias”. New Eng. J. Med. 1959; 260: 1131
  • Gilbert H. S. A reappraisal of myeloproliferative disease concept. Mt. Sinai J. 1970; 37: 426
  • Hayhoe F. G. J., Quaglino D., Doll R. The Cytology and Cytochemistry of Acute Leukaemias. Her Majesty's Stationery Office, London 1964
  • Caspersson T., Gahrton C., Lindsten J., et al. Identification of the Philadelphia chromosome as a number 22 by quinacrine mustard fluorescence analysis. Exp. Cell Res. 1970; 63: 238

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