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Research Article

Recent Advances in Porphyrin Metabolism

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Pages 639-657 | Published online: 27 Sep 2008

References

  • Tschudy D. P. Biochemical lesions in porphyria. J.A.M.A. 1965; 191: 718
  • Watson C. J., Taddeini L. The clinical porphyrias. Seminars Hemat. 1968; 5: 335
  • Kappas A., Levere R. D., Granick S. The regulation of porphyrin and heme synthesis. Seminars Hemat. 1968; 5: 323
  • Sano S., Granick S. Mitochondrial coproporphyrinogen oxidase and protoporphyrin formation. J. Biol. Chem. 1961; 236: 1173
  • Sardesai V. M., Waldman J., Orten J. M. A comparative study of porphyrin biosynthesis in different tissues. Blood 1964; 24: 178
  • Granick S., Urata G. Increase in activity of a-aminolevulinic acid synthetase in liver mitochondria induced by feeding of 3, 5-dicarbethoxy, -1, 4-dihydrocollidine. J. Biol. Chem. 1963; 238: 821
  • Lascelles J. Tetrapyrrole Biosynthesis and its Regulation. W. A. Benjamin, Inc., New York 1966
  • Granick S. The induction in vitro of the synthesis of δ-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals. J. Biol. Chem. 1966; 241: 1359
  • McKay R., Druyan R., Getz G. S., Rabinowitz M. Intramitochondrial localization of δ-amino laevulate synthetase and ferrochelatase in rat liver. Biochem J. 1969; 114: 455
  • Jones M. S., Jones O. T. G. Evidence for the location of ferrochelatase on the inner membrane of rat liver mitochondria. Biochem. Biophys. Res. Comm. 1968; 31: 977
  • Marver H. S., Tschudy D. P., Perlroth M. G., Collins A. δ-aminolevulinic acid synthetase. I. Studies in liver homogenates. J. Biol. Chem. 1966; 241: 2803
  • Hayashi N., Yoda B., Kikuchi G. Mechanism of allylisopropyl-acetamide-induced increase of δ-amino-levulinate synthetase in liver mitochondria IV. Accumulation of the enzyme in the soluble fraction of rat liver. Arch. Biochem. 1969; 131: 83
  • Scholnick P. L., Hammaker L. E., Marver H. S. Soluble hepatic δ-aminolevulinic acid synthetase: end-product inhibition of the partially purified enzyme. Proc. Nat. Acad. Sci. 1969; 63: 65
  • London I. M., Bruno G. P., Karibian D. The regulation of hemoglobin synthesis and the pathogenesis of some hypochromic anemias. Medicine 1964; 43: 789
  • Karibian D., London I. M. Control of heme synthesis by feedback inhibition. Biochem. Biophys. Res. Comm. 1965; 18: 243
  • Welland F., Schwartz H. C. Effect of hemin on ALA synthetase. Clin. Res. 1966; 14: 142
  • Bottomley S. S., Smithee J. A. Characterization and measurement of δ-aminolevulinate synthetase in bone marrow cell mitochondria. Biochim. Biophys. Acta. 1968; 159: 27
  • Neuwirt J., Ponka P., Borová J. The role of heme in the regulation of δ-aminolevulinic acid and heme synthesis in rabbit reticulocytes. Europ. J. Biochem. 1969; 9: 36
  • Marver H. S., Tschudy D. P., Perlroth M. G., Collins A. Coordinate synthesis of heme and apoenzyme in the formation of tryptophan pyrrolase. Science 1966; 154: 501
  • Feigelson P., Feigelson M., Greengard O. Comparison of the mechanisms of hormonal and substrate induction of rat liver tryptophan pyrrolase. Recent Progr. Hormone Res. 1962; 18: 491
  • Onisawa J., Labbe R. F. Effects of diethyl-l, 4-dihydro-2, 4, 6, -trimethylpyridine-3, 5-dicarboxylate on the metabolism of porphyrins and iron. J. Biol. Chem. 1963; 238: 724
  • Wada O., Yano Y., Urata G., Nakao K. Behaviour of hepatic microsomal cytochromes after treatment of mice with drugs known to disturb porphyrin metabolism in liver. Biochem. Pharmacol. 1968; 17: 595
  • Creighton J. M., Marks G. P. Drug induced porphyrin biosynthesis I. The effect of porphyria inducing drugs on N-demethylase activity of chick embryo liver. Biochem. Pharmacol. 1969; 18: 2040
  • Schmid R., Marver H. S., Hammaker L. Enhanced formation of rapidly labeled bilirubin by phenobarbital. Hepatic microsomal cytochrome as a possible source. Biochem. Biophys. Res Comm 1966; 24: 319
  • Robinson S. H., Tsong M., Brown B. W., Schmid R. The sources of bile pigment in the rat: Studies of the “early labeled” fraction. J. Clin. Invest. 1966; 45: 1569
  • Marver H. S. Experimental and acute intermittent porphyria: A suggested role of disordered drug metabolism. J. Lab. Clin. Med. 1966; 68: 996
  • Meyer U. A., Marver H. S. Hepatic porphyria: inappropriate induction of delta aminolevulinic acid synthetase by enhanced hemoprotein turnover. J. Clin. Invest. 1970; 49: 66a
  • Meyer U. A., Marver H. S. Chemically induced porphyria: Increased microsomal heme turnover after treatment with allylisopropyl-acetamide. Science 1971; 171: 64
  • Landaw S. A., Callahan E. W., Jr., Schmid R. Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide. J. Clin. Invest. 1970; 49: 914
  • Sassa S., Granick S. Induction of δ-aminolevulinic acid synthetase in chick embryo liver cells in culture. Proc. Nat. Acad. Sci. 1970; 67: 517
  • Granick S., Levere R. D. Heme synthesis in erythroid cells. Progr. Hemat. 1964; 4: 1
  • Watson C. J., Runge W., Taddeini L., Bossenmaier I., Cardinal R. A suggested control gene mechanism for the excessive production of types I and III porphyrins in congenital erythropoietic porphyria. Proc. Nat. Acad. Sci. 1964; 52: 487
  • Tschudy D. P., Perlroth M. G., Marver H. S., Collins A., Hunter G. J., Rechail M. J. Acute intermittent porphyria: the first Overproduction Disease localized to a specific enzyme. Proc. Nat. Acad. Sci. 1965; 53: 841
  • Heilmeyer V. L., Clotten R. Die Storung der Porphyrinsynthese bei der Guntherschen Porphyria Congenita. Acta Haemat. 1965; 34: 65
  • Romeo G., Levin E. Y. Uroporphyrinogen III cosynthetase in human congenital erythropoietic porphyria. Biochemistry 1969; 63: 856
  • Masuya T. Pathophysiological observations on porphyrias. Acta Haemat. Jap. 1969; 32: 24
  • Levin E. Y. Uroporphyrinogen III cosynthetase from mouse spleen. Biochemistry 1968; 7: 3781
  • Levere R. D., Kappas A., personal communication
  • Schwartz S., Johnson J. A., Stephenson B. D., Anderson A. S., Edmonson P. R., Fusaro R. M. Erythropoietic defects in protoporphyria: A reevaluation of early peak labeling. J. Lab. Clin. Med. 1970; 76: 893
  • Porter F. S. Congenital erythropoietic protoporphyria II. An experimental study. Blood 1963; 22: 532
  • Miyagi K. The liver ALA synthetase activity in erythropoietic protoporphyria by means of the new micromethod. J. Kyushi Hemat. Soc. 1967; 17: 397
  • Scholnick P., Marver H. S., Schmid R. Erythropoietic protoporphyria: Evidence for multiple sites of excess protoporphyrin formation. J. Clin. Invest. 1971; 50: 203
  • Schwartz S., Johnson J. A., Stephenson B. D., Anderson A. S., Edmonson P. R., Fusaro R. M. Erythropoietic defects in protoporphyria; a study of factors involved in labelling of porphyrins and bile pigments from ALA-3H and Glyein-3 4C. J. Lab. Clin. Med., in press
  • Strand L. J., Felsher B. F., Redeker A. G., Marver H. S. Intermittent acute porphyria (IAP). New evidence for a basic defect in uroporphyrinogen synthetase (UROS). J. Clin. Invest. 1971; 50: 89a
  • Nakao K., Wada O., Kitamura T., Uono M. Activity of aminolaevulinic acid synthetase in normal and porphyric human livers. Nature 1966; 210: 838
  • Dowdle E. B., Mustard P., Eales L. δ-aminolevulinic acid synthetase activity in normal and porphyric human livers. S. Afr. Med. J. 1967; 41: 1093
  • Heilmeyer L., Clotten R. Zur biochemischen Pathogenese der Porphyria Acuta Intermittens. Klin. Wschr. 1969; 47: 71
  • Sweeny V. P., Pathak M. A., Asbury A. K. Acute intermittent porphyria. Increased ALA synthetase activity during an acute attack. Brain 1970; 93: 369
  • Strand L. J., Felsher B. F., Redeker A. G., Marver H. S. Heme biosynthesis in intermittent acute porphyria. Decreased hepatic conversion of porphobilinogen to porphyrins and increased delta aminolevulinic acid synthetase activity. Proc. Nat. Acad. Sci. 1970; 67: 1315
  • Miyagi K., Cardinal R., Bossenmaier J., Watson C. J. The serum porphobilinogen and the hepatic porphobilinogen deaminase in normal and porphyric individuals, in press
  • Kaufman L., Marver H. S. Biochemical defects in two types of human hepatic porphyria. New Eng. J. Med. 1970; 283: 954
  • McLntyre N., Pearson A. J. G., Allan D. J., Craske S., West G. M. L., Moore M. R., Paxton J., Beattie A. D., Goldberg A. Hepatic δ-aminolaevulinic acid synthetase in an attack of hereditary coproporphyria and during remission. Lancet 1971; 1: 560
  • Watson C. J. The problem of porphyria. Some facts and questions. New Eng. J. Med. 1960; 263: 1205
  • Zail S. S., Joubert S. M. Hepatic δ-aminolaevulinic acid synthetase activity in symptomatic porphyria. Brit. J. Haemat. 1968; 15: 123
  • Shanley B. C., Zail S. S., Joubert S. M. Effect of ethanol on liver δ-aminolaevulinate synthetase activity and urinary porphyrin excretion in symptomatic porphyria. Brit. J. Haemat. 1969; 17: 389
  • Levere R. D. Porphyrin synthesis in hepatic cirrhosis: Increase in δ-aminolevulinic acid synthetase. Biochem. Med. 1967; 1: 92
  • Levere R. D. Stilbesterol induced porphyria: Increase in hepatic δ-aminolevulinic acid synthetase. Blood 1966; 28: 569
  • Lottsfeldt F. I., Labbe R. F. Iron metabolism in experimental porphyria. Clin. Res. 1961; 9: 93
  • Tschudy D. P. Acute intermittent porphyria. Seminars Hemat. 1968; 5: 370
  • Magnus I. A. The cutaneous porphyrias. Seminars Hemat. 1968; 5: 380
  • DeMatteis E. Toxic hepatic porphyrias. Seminars Hemat. 1968; 5: 409
  • Hellman E. S., Tschudy D. P., Bartter F. C. Abnormal electrolyte and water metabolism in acute intermittent porphyria. Amer. J. Med. 1962; 32: 734
  • Nielsen B., Thorn N. A. Transient excess urinary excretion of antiduiretic material in acute intermittent porphyria with hyponatremia and hypomagnesemia. Amer. J. Med. 1965; 38: 345
  • Perlroth M. G., Tschudy D. P., Marver H. S., Berard C. W., Zeigel R. F., Rechcigl M., Collins A. Acute intermittent porphyria. New morphologic and biochemical findings. Amer. J. Med. 1966; 41: 149
  • Ludwig G. D., Goldberg M. Hyponatremia in acute intermittent porphyria probably resulting from inappropriate secretion of antiduiretic hormone. Ann New York Acad. Sci. 1963; 104: 710
  • Stein J. A., Tschudy D. P. Acute intermittent porphyria. A clinical and biochemical study of 46 patients. edicine 1970; 49: 1
  • Tschudy D. P. Clinical aspects of drug reactions in hereditary hepatic porphyria. Ann N. Y. Acad. Sci 1968; 151: 850
  • Henneman D. H., Bunker J. P. The pattern of intermediary carbohydrate metabolism in Cushing's syndrome. Amer. J. Med. 1957; 23: 34
  • Wynn V., Doar J. W. H. Some effects of oral contraceptives on carbohydrate metabolism. Lancet 1966; 2: 715
  • Welland F. H., Hellman E. S., Gaddis E. M., Collins A., Hunter G. W., Jr., Tschudy D. P. Factors affecting the excretion of porphyrin precursors by patients with acute intermittent porphyria. I The effect of diet. Metabolism 1964; 13: 232
  • Perlroth M. G., Tschudy D. P., Ratner A., Spaur W., Redeker A. The effect of diet in Variegate (South African) Porphyria. Metabolism 1968; 17: 571
  • Redeker A. D., Sterling R. E. The “glucose effect” in erythropoietic protoporphyria. Arch. Intern. Med. 1968; 121: 446
  • Rose J. A., Hellman E. S., Tschudy D. P. Effect of diet on induction of experimental porphyria. Metabolism 1961; 10: 514
  • Tschudy D. P., Welland F. H., Collins A., Hunter G. The effect of carbohydrate feeding on the induction of δ-aminolevulinic acid synthetase. Metabolism 1964; 13: 396
  • Zimmerman T. S., McMillin J. M., Watson C. J. Onset of manifestations of hepatic porphyria in relation to the influence of female sex hormones. Arch. Inter. Med. 1966; 118: 229
  • Granick S., Kappas A. Steroid control of porphyrin and heme biosynthesis: A new biological function of steroid hormone metabolites. Proc. Nat. Acad. Sci 1967; 57: 1463
  • Kappas A., Granick S. Experimental hepatic porphyria: Studies with steroids of physiologic origin in man. Ann N. Y. Acad Sci 1968; 151: 842
  • Goldberg A., Moore M. R., Beattie A. D., Hall P. E., McCallum J., Grant J. K. Excessive urinary excretion of certain porphyrinogenic steroids in human acute intermittent porphyria. Lancet 1969; 1: 115
  • Kappas A., Song C. S., Sassa S., Levere R. D., Granick S. The occurrence of substances in human plasma capable of inducing the enzyme δ-aminolevulinate synthetase in liver cells. Proc. Nat. Acad. Sci. 1969; 64: 557
  • Hollander C. S., Scott R. L., Tschudy D. P., Perlroth M., Waxman A., Sterling K. Increased protein-bound iodine and thyroxine-binding globulin in acute intermittent porphyria. New Eng J. Med. 1967; 277: 995
  • Taddeini L., Nordstrom K. L., Watson C. J. Hypercholesterolemia in experimental and human hepatic porphyria. Metabolism 1964; 13: 691
  • Lees R. S., Song C. S., Levere R. D., Kappas A. Hyperbeta-lipoproteinemia in acute intermittent porphyria. New Eng. J. Med. 1970; 282: 432
  • Kappas A., Song C. S., Sachson R. A., Levere R. D., Granick S. The induction of δ-aminolevulinic acid synthetase in vivo in chick embryo liver by natural steroids. Proc. Nat. Acad. Sci 1968; 61: 509
  • Levere R. D., Granick S. Control of hemoglobin synthesis in the cultured chick blastoderm. J. Biol. Chem. 1967; 242: 1903
  • Levere R. D., Kappas A., Granick S. Stimulation of hemoglobin synthesis in chick blastoderm by certain 5β androstane and 5β pregnane steroids. Proc. Nat. Acad. Sci. 1967; 58: 985
  • Gordon A. S., Zanjani E. D., Levere R. D., Kappas A. Stimulation of mammalian erythropoiesis by 5β-H steroid metabolites. Proc. Nat. Acad. Sci. 1970; 65: 919
  • Gorsheim D., Gardner F. H. Erythropoietic activity of steroid metabolites in mice. Proc. Nat. Acad. Sci. 1970; 65: 564
  • Mizoguchi H., Levere R. D. Enhancement of heme and globin synthesis in cultured human marrow by certain 5β-H steroid metabolites. J. Exp. Med. December, 1971, in press
  • Kappas A., Bradlow H. L., Gillette P. M., Gallagher T. F. Abnormal steroid hormone metabolism in the genetic liver disease with intermittent porphyria. Proc. Nat. Acad. Sci. 1971; 179: 611

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