The Pathogenesis of Immune Thrombocytopenic Purpura

References

• Baldini M. Idiopathic thrombocytopenic purpura. N. Engl. J. Med. 1966; 274: 1245–1301, 1360
   PubMed Web of Science ®Google Scholar
• Karpatkin S. Autoimmune thrombocytopenic purpura. Am. J. Med. Sci. 1971; 261: 127
   PubMedGoogle Scholar
• Aster R. H. Chronic idiopathic thrombocytopenic purpura (Werhof's disease, purpura hemorrhagica, essential thrombocytopenia). Hematology, W. J. Williams, E. Beutler, A. J. Erslev, R. W. Rundles. McGraw-Hill. 1972; 1146
   Google Scholar
• Garg S. K., Amorosi E. L., Karpatkin S. Use of the megathrombocyte as an index of megakaryocyte number. N. Engl. J. Med. 1971; 284: 11
   PubMed Web of Science ®Google Scholar
• Ziegler Z., Murphy S., Gardner F. H. Microscopic platelet size and morphology in various hematologic disorders (abstr.). Blood 1976; 48: 1006
   Google Scholar
• Hirsch E. O., Gardner F. H. Transfusion of human blood platelets: with note on transfusion of granulocytes. J. Lab. Clin. Med. 1952; 39: 556
   PubMedGoogle Scholar
• Harrington W. J., Sprague C. C., Minnich V., Moore C. V., Aulvin R. C., Dubach R. Immunologic mechanisms in idiopathic and neonatal thrombocytopenic purpura. Ann. Intern. Med. 1953; 38: 433
   PubMed Web of Science ®Google Scholar
• Cohen P., Gardner F. H., Barnett G. O. Reclassification of the thrombocytopenias by the Cr51 -labeling method for measuring platelet life span. N. Engl. J. Med. 1961; 264: 1294
   PubMed Web of Science ®Google Scholar
• Aster R. H., Jandel J. H. Platelet sequestration in man. I. Methods. J. Clin. Invest. 1964; 43: 843
   PubMed Web of Science ®Google Scholar
• Harker L. A., Finch C. A. Thrombokinetics in man. J. Clin. Invest. 1969; 48: 963
   PubMed Web of Science ®Google Scholar
• Aster R. H. Pooling of platelets in the spleen: role in the pathogeneses of “hypersplenic” thrombocytopenia. J. Clin. Invest. 1966; 45: 645
   PubMed Web of Science ®Google Scholar
• Kotilainen M. Platelet kinetics in normal subjects and in hematological disorders. Scand. J. Haematol., Suppl. 1969; 5: 5
   Google Scholar
• Branehög I., Kutti J., Weinfeld A. Platelet survival and platelet production in idiopathic thrombocytopenic purpura (ITP). Br. J. Haematol. 1974; 27: 127
   PubMed Web of Science ®Google Scholar
• Kutti J., Weinfeld A., Westin J. The relationship between splenic platelet pool and spleen size. Scand. J. Haematol. 1972; 9: 351
   PubMedGoogle Scholar
• Aster R. H., Keene W. R. Sites of platelet destruction in idiopathic thrombocytopenic purpura. Br. J. Haematol. 1969; 16: 61
   PubMed Web of Science ®Google Scholar
• Branehög I., Weinfeld A., Roos B. The exchangeable splenic platelet pool studied with epinephrine infusion in idiopathic thrombocytopenic purpura and in patients with splenomegaly. Br. J. Haematol. 1973; 25: 239
   PubMed Web of Science ®Google Scholar
• Najean Y., Ardaillou N. The sequestration site of platelets in idiopathic thrombocytopenic purpura: its correlation with the results of splenectomy. Br. J. Haematol. 1971; 21: 153
   Google Scholar
• Ries C. A., Price D. C. [51Cr] platelet kinetics in thrombocytopenia. Ann. Intern. Med. 1970; 80: 702
   Google Scholar
• Harker L. A. Thrombokinetics in idiopathic thrombocytopenic purpura. Br. J. Haematol. 1970; 19: 95
   PubMed Web of Science ®Google Scholar
• Branehög I., Kutti J., Ridell B., Swolin B., Weinfeld A. The relation of thrombokinetics to bone marrow megakaryocytes in idiopathic thrombocytopenic purpura (ITP). Blood 1975; 45: 551
   PubMed Web of Science ®Google Scholar
• Branehög I., Weinfeld A. Platelet survival and platelet production in idiopathic thrombocytopenic purpura (ITP) before and during treatment with corticosteroids. Br. J. Haematol. 1974; 12: 69
   Google Scholar
• Branehög I. Platelet kinetics in idiopathic thrombocytopenic purpura (ITP) before and at different times after splenectomy. Br. J. Haematol. 1975; 29: 413
   Google Scholar
• Harrington W. J., Minnich V., Hollingsworth J. W., Moore C. V. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J. Lab. Clin. Med. 1951; 38: 1
   PubMed Web of Science ®Google Scholar
• Harrington W. J., Minnich V., Arimura G. The autoimmune thrombocytopenias. Prog. Hematol. 1956; 1: 166
   PubMedGoogle Scholar
• Shulman N. R., Marder V. J., Weinrach R. S. Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura. Physiologic, serologic and isotopic studies. Ann. N. Y. Acad. Sci. 1965; 124: 499
   PubMed Web of Science ®Google Scholar
• Shulman N. R., Weinrach R. S., Libre E. P., Andrews H. L. The role of the reticuloendothelial system in the pathogeneses of idiopathic thrombocytopenic purpura. Trans. Assoc. Am. Physicians 1975; 78: 374
   Google Scholar
• Sprague C. C., Harrington W. J., Lange R. D., Shapleigh J. B. Platelet transfusions and the pathogenesis of idiopathic thrombocytopenic purpura. JAMA 1952; 150: 1193
   Google Scholar
• Karpatkin S., Strick N., Karpatkin M. D., Siskind G. W. Cumulative experience in the detection of antiplatelet antibody in 234 patients with idiopathic thrombocytopenic purpura, systemic lupus erythematosus and other clinical disorders. Am. J. Med. 1972; 52: 776
   PubMed Web of Science ®Google Scholar
• Hirschman R. J., Shulman N. R. The use of platelet serotonin release as a sensitive method for detecting antiplatelet antibodies and a plasma antiplatelet factor in patients with idiopathic thrombocytopenic purpura. Br. J. Haematol. 1973; 24: 793
   Google Scholar
• Handin R. I., Piessens W. F., Moloney W. C. Stimulation of nonimmunized lymphocytes by platelet-antibody complexes in idiopathic thrombocytopenic purpura. N. Engl. J. Med. 1973; 289: 714
   Google Scholar
• Handin R. I., Stossel T. P. Phagocytosis of antibody-coated platelets by human granulocytes. N. Engl. J. Med. 1974; 290: 989
   PubMedGoogle Scholar
• McMillan R., Smith R. S., Longmire R. L., Yelenosky R., Reid R. T., Craddock C. G. Immunoglobulins associated with human platelets. Blood 1971; 37: 316
   PubMed Web of Science ®Google Scholar
• Dixon, Rosse R. W., Ebbert L. Quantitative determination of antibody in idiopathic thrombocytopenic purpura. N. Engl. J. Med. 1975; 292: 230
   PubMed Web of Science ®Google Scholar
• Dausset J., Columbani J., Columbani M. Study of leukopenias and thrombocytopenias by the direct antiglobulin consumption test on leukocytes and/or platelets. Blood 1961; 18: 672
   PubMedGoogle Scholar
• Van de Wiel Th. W. M., van de Wiel-Dorfmeyer H., van Loghem J. J. Studies on platelet antibodies in man. Vox Sang. 1961; 6: 641
   PubMedGoogle Scholar
• Dixon R., Rosse W. Platelet antibody in autoimmune thrombocytopenia. Br. J. Haematol. 1975; 31: 129
   PubMed Web of Science ®Google Scholar
• Luiken G. A., McMillan R., Lightsey A. L., Gordon P., Zevely S., Schulman I., Gribble T. J., Longmire R. L. Platelet-associated IgG in immune thrombocytopenic purpura. Blood 1977; 50: 317
   PubMed Web of Science ®Google Scholar
• Karpatkin S., Strick N., Siskind G. W. Detection of splenic antiplatelet antibody synthesis in idiopathic autoimmune thrombocytopenic purpura (ATP). Br. J. Haematol. 1972; 23: 167
   PubMedGoogle Scholar
• McMillan R., Longmire R. L., Yelenosky R., Smith R. S., Craddock C. G. Immunoglobulin synthesis in vitro by splenic tissue in idiopathic thrombocytopenic purpura. N. Engl. J. Med. 1972; 286: 681
   PubMedGoogle Scholar
• McMillan R., Longmire R. L., Yelenosky R., Donnell R. L., Armstrong S. Quantitaion of platelet-binding McMillan, R., Longmire, R. L., Yelenosky, R., Donnell, R. L., and Armstrong, S., Quantitation of platelet-binding IgG produced in vitro by spleens from patients with idiopathic thrombocytopenic purpura. N. Engl. J. Med. 1974; 291: 812
   Google Scholar
• McMillan R., Yelenosky R. J., Longmire R. L. Immunoaspects of the Spleen, J. R. Battisto, W. J. Streilein. North-Holland, Amsterdam 1976; 227
   Google Scholar
• Shulman N. R., Marder V. J., Miller M. C. Platelet and leukocyte isoantigens and their antibodies: serologic, physiologic and clinical studies. Prog. Hematol. 1964; 4: 222
   PubMedGoogle Scholar
• Shulman N. R. Mechanism of blood cell damage by adsorption of antigen-antibody complexes. 3d Int. Symp. on Immunopathology, P. Grabar, P. B. Miescher. Schwabe, Basel 1963; 338
   Google Scholar
• Piessens W. F., Wybran J., Manaster J., Strijckmans P. A. Lymphocyte transformation induced by autologous platelets in a case of thrombocytopenic purpura. Blood 1970; 36: 421
   PubMed Web of Science ®Google Scholar
• Wybran J., Fudenberg H. H. Cellular immunity in idiopathic thrombocytopenic purpura. Blood 1972; 40: 856
   PubMed Web of Science ®Google Scholar
• Clancy R. Cellular immunity to autologous platelets and serum-blocking factors in idiopathic thrombocytopenic purpura. Lancet 1972; 1: 6
   PubMed Web of Science ®Google Scholar
• Firkin B. G., Wright R., Miller S., Stokes E. Splenic macrophages in thrombocytopenia. Blood 1969; 33: 240
   Google Scholar
• Summerall J. M., Gibbs W. N. Splenic histiocytosis associated with thrombocytopenia. Acta Haematol. (Basel) 1972; 48: 34
   Google Scholar
• Tavassoli M., McMillan R. Structure of the spleen in idiopathic thrombocytopenic purpura. Am. J. Clin. Pathol. 1975; 64: 180
   Google Scholar
• McMillan R., Longmire R. L., Tavassoli M., Armstrong S., Yelenosky R. In vitro platelet phagocytosis by splenic leukocytes in idiopathic thrombocytopenic purpura. N. Engl. J. Med. 1974; 290: 249
   PubMed Web of Science ®Google Scholar
• Stossel T. P. Phagocytosis. N. Engl. J. Med. 1974; 290: 717–774, 833
   PubMed Web of Science ®Google Scholar
• Hauch T. W., Rosse W. F. Platelet membrane-bound IgG and third component of complement (C3); response to therapy (abstr.). Blood 1976; 48: 986
   Google Scholar
• Karpatkin S., Schur P. H., Strick N., Siskind G. W. Heavy chain subclass of human anti-platelet antibodies. Clin. Immunol. Immunopathol. 1973; 2: 1
   PubMedGoogle Scholar
• Saba T. Physiology and physiopathology of the reticuloendothelial system. Arch. Intern. Med. 1970; 126: 1031
   PubMed Web of Science ®Google Scholar
• Tavassoli M. Bone marrow erythroclasia: the function of perisinal macrophages relative to the uptake of erythroid cells. J. Reticuloendothel. Soc. 1974; 15: 163
   Google Scholar
• Shulman N. R. A mechanism of cell destruction in individuals sensitized to foreign antigens and its implications in autoimmunity. Ann. Intern. Med. 1964; 60: 506
   PubMed Web of Science ®Google Scholar
• Karpatkin S., Siskind G. W., Zucker M. B. Studies on the specificity of antiplatelet autoantibodies. Proc. Soc. Exp. Biol. Med. 1974; 147: 715
   Google Scholar
• McMillan R., Yelenosky R. J., Longmuir R. L., Lightsey A. L., Donnell R. L. Different antiplatelet antibody specificities in immune thrombocytopenic purpura. Br. J. Haematol. 1976; 34: 147
   Google Scholar
• Levine R. F., Fedorko M. E. Isolation of intact megakaryocytes from guinea pig femoral marrow. J. Cell Biol. 1976; 69: 159
   Google Scholar
• Benner R., Meima F., van der Meulen G. M., and van Muiswinkel W. B. Antibody formation in the mouse bone marrow. I. Evidence for the development of plaque-forming cells in situ. Immunology 1974; 26: 247
   PubMedGoogle Scholar
• Mellbye O. J. Antibody-producing cells in bone marrow and other lymphoid tissues during the primary immune response in mice. Int. Arch. Allergy Appl. Immunol. 1971; 40: 248
   Google Scholar
• Askonas B., Humphrey J. H. Formation of specific antibodies and gammaglobulins in vitro. A study of the synthetic ability of various tissues from rabbits immunized by different methods. Biochem. J. 1958; 68: 252
   PubMed Web of Science ®Google Scholar
• Rowley D. A. The effect of splenectomy on the formation of circulating antibody in the adult male albino rat. J. Immunol. 1950; 64: 289
   Google Scholar
• Hill S. W. Distribution of plaque-forming cells in the mouse for a protein antigen. Immunology 1976; 30: 895
   Google Scholar
• Rowley D. A. The formation of circulating antibody in the splenectomized human being following intravenous injection of heterologous erythrocytes. J. Immunol. 1950; 65: 515
   PubMed Web of Science ®Google Scholar
• McMillan R., Longmire R. L., Yelenosky R., Lang J. E., Heath V., Craddock C. G. Immunoglobulin synthesis by human lymphoid tissues: normal bone marrow as a major site of IgG production. J. Immunol. 1972; 109: 1386
   PubMed Web of Science ®Google Scholar
• Vaughan J. H., Chihara T., Moore T. L., Robbins D. L., Tanimoto K., Johnson J. S., McMillan R. Rheumatoid factor-producing cells detected by direct hemolytic plaque assay. J. Clin. Invest., in press
   Google Scholar
• Hijmans W., Schuit H. R. E., Hulsing-Hesselink E. An immunofluorescence study on intracellular immunoglobulins in human bone marrow cells. Ann. N. Y. Acad. Sci. 1971; 177: 290
   Google Scholar
• Benner R., Meima F., van der Meulen G. M. Antibody formation in mouse bone marrow. II. Evidence for a memory-dependent phenomenon. Cell Immunol. 1974; 13: 95
   Google Scholar
• Benner R., van Oudenaren A. Antibody formation in mouse bone marrow. IV. The influence of splenectomy on the bone marrow plaque-forming cell response to sheep red blood cells. Cell. Immunol. 1975; 19: 167
   Google Scholar
• Benner R., van Oudenaren A. Antibody formation in mouse bone marrow. V. The response to the thymus-independent antigen Escherichia coli lipopolysaccharide. Immunology 1976; 30: 49
   Google Scholar
• Carpenter A. F., Wintrobe M. M., Fuller E. A., Haut A., Cartwright G. E. Treatment of idiopathic thrombocytopenic purpura. JAMA 1959; 171: 103
   Google Scholar
• Schulman I., personal communications
   Google Scholar
• Hauch T. W., Rosse W. F., personal communication
   Google Scholar