Current Considerations in Digoxin Usage

References

• Henderson F. G. Chemistry and biological activity of the cardiac glycosides. Digitalis, C. Fisch, B. Surawicz. Grune & Stratton, New York 1969; 3
   Google Scholar
• Okita G. T. Distribution, disposition and excretion of digitalis glycosides. Digitalis, C. Fisch, B. Surawicz. Grune & Stratton, New York 1969; 13
   Google Scholar
• Doherty J. E., Kane J. J. Clinical pharmacology of digitalis glycosides. Ann. Rev. Med. 1975; 26: 159
   PubMed Web of Science ®Google Scholar
• Doherty J. E. Digoxin glycosides. Pharmacokinetics and their clinical implications. Ann. Intern. Med. 1973; 79: 229
   PubMedGoogle Scholar
• Okita G. T., Talso P. J., Curry J. H., Jr., Smith F. D. J., Geiling E. M. K. Metabolic fate of radioactive digitoxin in human subjects. J. Pharmacol. Exp. Ther. 1955; 115: 371
   PubMed Web of Science ®Google Scholar
• Okita G. T. Species differences in duration of action of cardiac glycosides. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1967; 26: 1125
   PubMedGoogle Scholar
• Doherty J. E., Flanigan W. F., Murphy M. L., Bulloch R. T., Dalrymple G. L., Beard O. W., Perkins W. H. Tritiated digoxin. XIV. Enterophepatic circulation, absorption and excretion studies in human volunteers. Circulation 1970; 42: 867
   PubMedGoogle Scholar
• Caldwell J. H., Martin J. F., Dutta S., Greenberger N. J. Intestinal absorption of digoxin - 3H in the rat. Am. J. Physiol. 1969; 217: 1747
   PubMed Web of Science ®Google Scholar
• Beermann B., Hellstrom K., Rosen A. The absorption of orally administered (12G - 3H) digoxin in man. Clin. Sci. 1972; 43: 507
   PubMedGoogle Scholar
• Hall W. H., Doherty J. I. Tritiated digoxin. XVI. Gastric absorption. Am. J. Dig. Dis. 1971; 16: 903
   PubMedGoogle Scholar
• Anderson K. E., Nybert L., Dencker H., Gothlin J. Absorption of digoxin in man after oral and intrasigmoid administration. Studied by portal vein catheterization. Eur. J. Clin. Pharmacol. 1975; 9: 39
   PubMedGoogle Scholar
• Lukas D. S. Changing concepts of digitalis therapy and toxicity. Cardiovascular Problems: Perspectives and Progress, H. I. Russek. University Park Press, Baltimore 1976; 295
   Google Scholar
• Taubert K., Shapiro W. Altered tissue digoxin Uptake after a toxic dose. Recent Adv. Stud. Card. Struct. Mctab. 1975; 5: 387
   PubMedGoogle Scholar
• Doherty J. E., Perkins W. H., Flanigan W. J. The distribution and concentration of tritiated digoxin in human tissues. Ann. Intern. Med. 1967; 66: 116
   PubMed Web of Science ®Google Scholar
• Marks B. H. Factors that affect the accumulation of digitalis glycosides by the heart. Basic and Clinical Pharmacology of Digitalis. Mards, B. H. and Weissler, A. M., Charles C Thomas, Springfield, Ill 1972
   Google Scholar
• Gault M. H., Jeffrey J. R., Chirito E., Ward L. L. Studies of digoxin dosage, kinetics and serum concentrations in renal failure and review of the literature. Nephron 1976; 17: 161
   PubMed Web of Science ®Google Scholar
• Doherty J. E., Bissett J. K., Kane J. J., DeSoyza N., Murphy M. L., Flanigan W. J., Dalrymple G. V. Tritiated digoxin studies in renal disease in human subjects. Int. J. Clin. Pharmacol. Biopharm. 1975; 21: 89
   Google Scholar
• Koup J. R., Greenblatt D. J., Jusko W. J., Smith T. W., Koch-Weser J. Pharmacokinetics of digoxin in normal subjects after intrevenous bolus and infusion doses. J. Pharmacokinet. Biopharm. 1975; 3: 181
   PubMedGoogle Scholar
• Steiness E. Renal tubular secretion of digoxin. Circulation 1974; 50: 103
   PubMed Web of Science ®Google Scholar
• Halkin H., Sheiner L. B., Peck C. C., Melmon K. L. Determinants of the renal clearance of digoxin. Clin. Pharmacol. Ther. 1975; 17: 385
   PubMedGoogle Scholar
• Doherty J. E., Hall W. H. Tritiated digoxin. XV. Serum protein binding in human subjects. Am. J. Cardiol. 1971; 28: 326
   PubMed Web of Science ®Google Scholar
• Storstein L. Studies on digitalis. V. The influence of impaired renal function, hemodialysis, and drug interaction on serum protein binding of digitoxin and digoxin. Clin. Pharmacol. Ther. 1976; 20: 6
   PubMedGoogle Scholar
• Bissett J. K., Doherty J. E., Flanigan W. J., Dalrymple G. V. Tritiated digoxin. XIX. Turnover studies in diabetes insipidus. Am. J. Cardiol. 1973; 31: 327
   PubMedGoogle Scholar
• Koch-Weser J. Serum drug concentrations as therapeutic guides. N. Engl. J. Med. 1972; 287: 227
   PubMed Web of Science ®Google Scholar
• Butler V. P., Lindenbaum J. Serum digitalis measurements in the assessment of digitalis resistance and sensitivity. Am. J. Med. 1975; 58: 469
   Google Scholar
• Harter J. G., Skelly J. P., Steers A. W. Editorial: Digoxin – the regulatory viewpoint. Circulation 1974; 49: 395
   PubMedGoogle Scholar
• Goldfinger S. E. Dissimilarities of digoxin. N. Engl. J. Med. 1971; 285: 1376
   PubMedGoogle Scholar
• Wagner J. G. Appraisal of digoxin bioavailability and pharmacokinetics in relation to cardiac therapy. Am. Heart J. 1974; 88: 133
   PubMedGoogle Scholar
• Lindenbaum J., Mellaw M. H., Blackston M. O., Butler V. P., Jr. Variation in biologic availability of digoxin from four preparations. N. Engl. J. Med. 1971; 285: 1344
   PubMed Web of Science ®Google Scholar
• Doherty J. E. Digoxin availability “like it is”. N. Engl. J. Med. 1972; 286: 266
   PubMedGoogle Scholar
• Koch-Weser J. Bioavailability of drugs. II. S. Engl. J. Med. 1974; 291: 503
   PubMed Web of Science ®Google Scholar
• Editorial. What the practicing physician should know about digoxin bioavailability and how FDA action affects him?. Circulation 1974; 49: 399
   PubMedGoogle Scholar
• Lindenbaum J., Butler V. P., Jr., Murphy J. E., Cresswell R. M. Correlation of digoxin - tablet dissolution - rate with biological availability. Lancet 1973; 1: 1215
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Duhme D. W., Koch-Weser J., Smith T. W. Equivalent bioavailability from digoxin elixir and rapid-dissolution tablets. JAMA 1974; 229: 1774
   PubMedGoogle Scholar
• Greenblatt D. J., Duhme D. W., Koch-Weser J., Smith T. W. Assessment of methodology in single-dose studies of digoxin bioavailability. Pharmacology 1976; 14: 182
   PubMedGoogle Scholar
• Preibisz J. J., Butler V. P., Jr., Lindenbaum J. Digoxin tablet bioavailability: single-dose and steady-state assessment. Ann. Intern. Med. 1974; 81: 469
   PubMedGoogle Scholar
• Shaw T. R., Howard M. R., Hamer J. Recent changes in biological availability of digoxin. Effect of an alteration in “Lanoxin” tablets. Br. Heart J. 1974; 36: 85
   PubMedGoogle Scholar
• Greenblatt D. J., Duhme D. W., Koch-Weser J., Smith T. W. Intravenous digoxin as a bioavailability standard; slow infusion and rapid injection. Clin. Pharmacol. Ther. 1974; 15: 510
   PubMed Web of Science ®Google Scholar
• Greenblatt D. F., Duhme D. W., Koch-Weser J., Smith T. W. Comparison of one- and six-day urinary digoxin excretion in single-dose bioavailability studies. Clin. Pharmacol. Ther. 1974; 16: 812
   Google Scholar
• Lindenbaum J. Bioavailability of different lots of digoxin tablets from the same manufacturer. Clin. Pharmacol. Ther. 1975; 17: 296
   PubMedGoogle Scholar
• Marcus F. I., Dickerson J., Pippin S., Stafford M., Bressler R. Digoxin bioavailability: formulations and rates of infusions. Clin. Pharmacol. Ther. 1976; 20: 253
   PubMed Web of Science ®Google Scholar
• Schumacher G. E. Interpretation of bioavailability data by practitioners. J. Clin. Pharmacol. 1976; 16: 554
   PubMedGoogle Scholar
• Munro-Faure A. D., Fowle A. S., Fox J., Johnson B. F., Lader S. Recognition of variable bioavailability as an international problem: a review of the earlier studies. Postgrad. Med. J. 1974; 6(Suppl. 50)14
   Google Scholar
• Weintraub M., Au W. Y., Lasagna L. Compliance as a determinant of serum digoxin concentration. JAMA 1973; 224: 481
   PubMed Web of Science ®Google Scholar
• Lindenbaum J., Maulitz R. M., Buterl V. P., Jr. Inhibition of digoxin absorption by Neomycin. Gastroenterology 1976; 71: 199
   Google Scholar
• Lahiri K., Ertel N. Mechanism of diphenylhydantain (DPH) induced decrease in serum digoxin (DG) levels. Clin. Res. 1974; 22: 321a
   Google Scholar
• Brown D. D., Jubl R. P. Decreased bioavailability of digoxin due to antiacids and kaolin-pectin. N. Engl. J. Med. 1976; 295: 1034
   PubMed Web of Science ®Google Scholar
• Jubl R. P., Summers R. W., Ouillory J. K., Blaug S. M., Cheng F. H., Brown D. D. Effect of sulfasalojine on digoxin bioavailability. Clin. Pharmacol. Ther. 1976; 20: 387
   PubMedGoogle Scholar
• Greenberger N. J., Caldwell J. H. Studies on the intestinal absorption of 'H-digitalis glycosides in experimental animals and man. Basic and Clinical Pharmacology of Digitalis, B. H. Marks, A. M. Weissler. Charles C Thomas, Springfield, Ill 1972; 15
   Google Scholar
• Hall W. H., Shappell S. D., Doherty J. E. Effect of cholestyramine on digoxin absorption and excretion in man. Am. J. Cardiol. 1977; 39: 213
   PubMed Web of Science ®Google Scholar
• Brown D. D., Jubl R. P., Warner S. L. Decreased bioavailability of digoxin produced by dietary fiber and cholestyramine. Am. J. Cardiol. 1977; 39(Abstr.)297
   Google Scholar
• Smith T. W., Haber E. Digitalis. Little, Brown, Boston 1974
   Google Scholar
• Lukas D. S., Peterson R. E. Double isotope dilution derivative assay of digitoxin in plasma, urine and stool of patients maintained on the drug. J. Clin. Invest. 1966; 45: 782
   PubMed Web of Science ®Google Scholar
• Smith T. W., Butler V. P., Jr., Haber E. Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. N. Engl. J. Med. 1969; 281: 1212
   PubMed Web of Science ®Google Scholar
• Butler V. P., Chen J. P. Digoxin-specific antibodies. Proc. Natl. Acad. Sci. U.S.A. 1967; 57: 71
   PubMed Web of Science ®Google Scholar
• Lowenstein J. M., Corrill E. M. An improved method for measuring plasma and tissue levels of digitalis glycosides. J. Lab. Clin. Med. 1966; 67: 1048
   PubMedGoogle Scholar
• Shapiro W. Assay of digitalis in plasma. Clin. Res. 1969; 17(Abstr.)63
   Google Scholar
• Orahame-Smith D. G., Everst M. S. Measurement of digoxin in plasma and its use in diagnosis of digoxin intoxication. Br. Med. J. 1969; 1: 286
   PubMedGoogle Scholar
• Shapiro W., Narahara K., Taubert K. Relationship of plasma digitoxin to cardiac response following intravenous digitalization in man. Circulation 1970; 42: 1065
   PubMed Web of Science ®Google Scholar
• Shapiro W., Taubert K., Narahara K. Nonradioactive serum digoxin and digitoxin levels. Arch. Intern. Med. 1972; 130: 31
   PubMedGoogle Scholar
• Marcus F. I. Current concepts of digoxin therapy. Med. Concepts Cardiovasc. Dis. 1976; 45: 77
   PubMedGoogle Scholar
• Taubert K., Shapiro W. Serum digoxin levels using an 125I - labelled antigen: validation of method and observations on cardiac patients. Am. Heart J. 1975; 89: 79
   PubMedGoogle Scholar
• Pippin S. L., Marcus J. I. Letter: Digoxin immunoassay with use of 3(H) digoxin vs (125 I) Tyrosine-Methyl-Ester of digoxin. Clin. Chem. 1976; 22: 286
   PubMedGoogle Scholar
• Kuczala Z. J., Ahluwalia G. S. Evaluation of two digoxin radioimmunoassay procedures in which 125I - labeled digoxin is used. Clin. Chem. 1976; 22: 193
   PubMedGoogle Scholar
• Kubasik N. P., Hall J. L., Barold S. S., Volosin M. T., Sine H. E. Evaluation of the sensitivity of commercially available digoxin radioimmunoassay kits. Chest 1976; 70: 217
   PubMedGoogle Scholar
• Holtzman J. L., Shafer R. B., Erickson R. R. Methodological causes of discrepancies in radioimmunoassay for digoxin in human serum. Clin. Chem. 1974; 20: 1194
   PubMed Web of Science ®Google Scholar
• Kuno-Sakai H., Sakai H., Ritzmann S. E. Radioimmunoassay of digoxin – interference by digitoxin. Clin. Chem. 1975; 21: 156
   PubMedGoogle Scholar
• Resenthal A. F., Vargus M. G., Klass C. S. Evaluation of enzyme-multiplied immunoassay technology (EMIT) for determination of serum digoxin. Clin. Chem. 1976; 22: 1899
   PubMedGoogle Scholar
• Butler V. P., Jr. Assays of digoxin in the blood. Prog. Cardiovasc. Dis. 1972; 14: 571
   PubMedGoogle Scholar
• Ravel R., Schall R. F., Jr. Pitfalls in iodine -125digoxin measurement. Ann. Clin. Lab. Sci. 1976; 6: 365
   PubMedGoogle Scholar
• Shapiro B., Kollmann G. J., Heine W. I. Pitfalls in the application of digoxin determinations. Semin. Nucl. Med. 1975; 5: 205
   PubMedGoogle Scholar
• Lown B., Levine S. A. Current Concepts in Digitalis Therapy. Little, Brown, Boston 1954
   Google Scholar
• Pardee H. E. B. Rate of disappearance of digitalis from the body. JAMA 1919; 73: 1822
   Google Scholar
• Gold H. Digitalis elimination. Arch. Intern. Med. 1923; 32: 779
   Google Scholar
• Marcuf F. I., Burlahalter L., Cuceia C., Pavlovich J., Kapadia C. G. Administration of tritiaied digoxin with and without a loading dose: a metabolic study. Circulation 1966; 34: 865
   PubMedGoogle Scholar
• Lobovsky F. Y., Osborne R. K. Maintenance after rapid digitalization. N. Engl. J. Med. 1963; 268: 219
   PubMedGoogle Scholar
• Rosenblum H. Maintenance of digitalis effects after rapid parenteral digitalization. JAMA 1962; 182: 192
   PubMedGoogle Scholar
• Bigger J. T., Strauss H. C. Digitalis toxicity: drug interactions promoting toxicity and the management of toxicity. Semin. Drug Treat. 1972; 2: 147
   PubMedGoogle Scholar
• Weissler A. M., Snyder J. R., Schoenfeld C. D., Cohen S. Assay of digitalis glycosides in man. Am. J. Cardiol. 1966; 17: 768
   Google Scholar
• Chamberlain D. A. The relation of clinical effect to plasma digoxin concentration. Postgrad. Med. J. 1974; 6(Suppl. 50)29
   Google Scholar
• Manninen V., Reissell P., Paukkala E. Transient cardiac arrhythmia after single daily maintenance doses of digoxin. Clin. Pharmacol. Ther. 1976; 10: 266
   Google Scholar
• Sheiner L. B. The use of serum concentrations of digitalis for quantitative therapeutic decisions. Cardiovasc. Clin. 1974; 6: 141
   PubMedGoogle Scholar
• Carmthert S. O., Kelly J. C., McDevitt D. G. Plasma digitalis concentrations in patients on admission to hospital. Br. Heart J. 1974; 36: 707
   PubMedGoogle Scholar
• Fogelman A. M., LaMont J. T., Finkelstein S., Rado E., Pearce M. L. Fallibility of plasma-digoxin differentiating toxic from non-toxic patients. Lancet 1971; 2: 727
   PubMed Web of Science ®Google Scholar
• Huffman D. H., Crow J. W., Pentik Ainen P., Azurnoff D. L. Association between clinical cardiac status, laboratory parameters and digoxin usage. Am. Heart J. 1976; 91: 28
   PubMedGoogle Scholar
• Hoeschen R. J., Cuddy T. E. Dose-response relation between therapeutic levels of serum digoxin and systolic time intervals. Am. J. Cardiol. 1975; 35: 469
   PubMedGoogle Scholar
• Carliner N. H., Gilbert C. A., Pruitt A. W., Ooldbert L. I. Effects of maintenance digoxin therapy on systolic time intervals and serum digoxin concentrations. Circulation 1974; 50: 94
   PubMedGoogle Scholar
• Jelliffe R. W., Bueu J., Kalaba R. Reduction of digitalis toxicity by computer-assisted glycoside dosage regimens. Ann. Intern. Med. 1972; 77: 891
   PubMed Web of Science ®Google Scholar
• Peck C. C., Sheiner L. B., Martin C. M., Combs D. T., Metman K. L. Computer-assisted digoxin therapy. N. Engl. J. Med. 1974; 289: 441
   Google Scholar
• Sheiner L. B., Halkin H., Peck C., Rosenberg B., Melmom K. L. Improved computer-assisted digitalis therapy. A method using feedback of measured serum digitalis concentrations. Ann. Intern. Med. 1975; 82: 619
   PubMed Web of Science ®Google Scholar
• Jelliffe R. W., Brooker O. A nomogram for digitalis therapy. Am. J. Med. 1974; 57: 63
   PubMedGoogle Scholar
• Huffman D. H. Relationship between digoxin concentrations in serum and saliva. Clin. Pharmacol. Ther. 1975; 17: 310
   PubMedGoogle Scholar
• Doherty J. E. Digitalis assay by salivary electrolytes. N. Engl. J. Med. 1971; 285: 916
   PubMedGoogle Scholar
• Butler V. P., Jr., Lindenbaum J. Serum digitalis measurements in the assessment of digitalis resistance and sensitivity. Am. J. Med. 1975; 58: 460
   PubMedGoogle Scholar
• Heizer W. B., Smith T. W., Goldfinger S. E. Absorption of digoxin in patients with malabsorption syndromes. N. Engl. J. Med. 1971; 285: 257
   PubMedGoogle Scholar
• Beerman B., Hellstrom K., Rosen A. The gastrointestinal absorption of digoxin in seven patients with gastric or small intestinal reconstructions. Acta Med. Scand. 1973; 193: 293
   PubMedGoogle Scholar
• Jusko W. J., Conti D. R., Molson A., Kuritzky P., Giller J., Schultz R. Digoxin absorption from tablets and elixir. The effect of radiation-induced malabsorption. JAMA 1975; 230: 1554
   Google Scholar
• Hall W. H., Doherty J. E. Tritiated digoxin. XXII. Absorption and excretion in malabsorption syndromes. Am. J. Med. 1974; 56: 437
   PubMedGoogle Scholar
• Luchi R. J., Gruber J. W. Unusually large digitalis requirements: a study of altered digoxin metabolism. Am. J. Med. 1968; 45: 322
   PubMed Web of Science ®Google Scholar
• Young R. C., Nachman R. L., Horomitz H. I. Thromboaytopenia due to digitoxin: demonstration of antibody and mechanisms of action. Am. J. Med. 1966; 41: 605
   PubMed Web of Science ®Google Scholar
• Croxson M. S., Ibbertson H. K. Serum digoxin in patients with thyroid disease. Br. Med. J. 1975; 3: 566
   PubMedGoogle Scholar
• Edelman I. S. Thyroid thermogenesis. N. Engl. J. Med. 1974; 290: 1303
   PubMedGoogle Scholar
• Chamberlain D. A., White R. J., Howard M. R., Smith T. W. Plasma digoxin concentrations in patients with atrial fibrillation. Br. Med. J. 1970; 3: 429
   PubMed Web of Science ®Google Scholar
• Redfors A. Digoxin dosage and ventricular rate at rest and exercise in patients with atrial fibrillation. Acta Med. Scand. 1971; 190: 321
   PubMedGoogle Scholar
• Redfors A. Plasma digoxin concentration – its relation to digoxin dosage and clinical effects in patients with atrial fibrillation. Br. Heart J. 1972; 34: 383
   PubMedGoogle Scholar
• Goldman S., Probst P., Selzer A., Cobn K. Inefficacy of therapeutic serum levels of digoxin in controlling the ventricle rate in atrial fibrillation. Am. J. Cardiol. 1975; 35: 651
   PubMed Web of Science ®Google Scholar
• Klein M. D., McInervy K., Levine P. A., Ryan T. J. Digitalis tolerance in cardiomyopathy. Am. J. Cardiol. 1977; 39: 271, Abstr
   Google Scholar
• Singh S. Clinical pharmacology of digitalis glycosides: a developmental viewpoint. Pediatr. Ann. 1976; 5: 578
   PubMedGoogle Scholar
• Hayes C. J., Butler V. P., Jr., Oersony W. M. Serum digoxin studies in infants and children. Pediatrics 1973; 52: 561
   PubMedGoogle Scholar
• Hernandez A., Burton R. M., Pagtakhan R. D., Goldring D. Pharmacodynamics of 3H-digoxin in infants. Pediatrics 1969; 44: 418
   PubMedGoogle Scholar
• Dungan W. T., Doherty J. E., Harvey C., Char J., Dalrymple G. V. Tritiated digoxin 18 studies in infants and children. Circulation 1972; 46: 983
   PubMedGoogle Scholar
• Larese R. J., Mirkin G. L. Kinetics of digoxin absorption and relation of serum levels to cardiac arrhythmias in children. Clin. Pharmacol. Ther. 1974; 15: 387
   PubMedGoogle Scholar
• Savage M. O., Hibble A. G., Pickening D. Plasma digoxin concentration and urinary excretions during a “simpler” regimen of infant digitalization. Arch. Dis. Child. 1975; 50: 393
   PubMedGoogle Scholar
• Wettrell G., Anderson K. E. Absorption of digoxin in infants. Eur. J. Clin. Pharmacol. 1975; 9: 49
   PubMedGoogle Scholar
• Soyka L. F. Digoxin: placental transfer, effects on the fetus, and therapeutic use in the newborn. Clin. Perinatol. 1975; 2: 23
   PubMedGoogle Scholar
• Miller W., Gilliland K., Taubert K., Shapiro W. Canine maternal, fetal and neonatal digoxin interrelationships. Circulation 1974; 50: 192, Abstr.
   PubMedGoogle Scholar
• Lely A. W., Van Enter C. H. J. Large-scale digitalis intoxication. Br. Med. J. 1970; 3: 737
   PubMed Web of Science ®Google Scholar
• Ewy G. A., Kapadia G. G., Yao L., Lullin M., Marcus F. I. Digoxin metabolism in the elderly. Circulation 1969; 39: 449
   PubMed Web of Science ®Google Scholar
• Evered D. C., Chapman C. Plasma digoxin concentrations and digoxin toxicity in hospital patients. Br. Heart J. 1971; 33: 540
   PubMedGoogle Scholar
• Smith T. W. Digitalis toxicity: epidemiology and clinical use of serum concentration measurements. Am. J. Med. 1975; 58: 470
   PubMedGoogle Scholar
• Ingelfinger J. A., Goldman P. The serum digitalis concentration does it diagnose digitalis toxicity?. N. Engl. J. Med. 1976; 294: 867
   PubMed Web of Science ®Google Scholar
• Beller G. A., Smith T. W., Abelmann W. H., Haber E., Hood W. B., Jr. Digitalis intoxication. A prospective clinical study with serum level correlations. N. Engl. J. Med. 1971; 284: 989
   PubMed Web of Science ®Google Scholar
• Noble R. J., Rothbaum D. A., Watanabe A. M., Besch H. R., Fisch C. Limitations of serum digitalis levels. Cardiovasc. Clin. 1974; 6: 299
   PubMedGoogle Scholar
• Duhme D. W., Greenblatt D. J., Koch-Weser J. Reduction of digoxin toxicity associated with determination of serum levels: a report of the Boston collaborative drug surveillance program. Ann. Intern. Med. 1974; 80: 516
   PubMed Web of Science ®Google Scholar
• Koch-Weser J., Duhme D. W., Greenblatt D. J. Influence of serum digoxin concentration measurements on frequency of digitoxicity. Clin. Pharmacol. Ther. 1974; 16: 284
   PubMed Web of Science ®Google Scholar
• Doherty J. E. Digitalis serum levels: clinical use. Ann. Intern. Med. 1971; 74: 787
   PubMed Web of Science ®Google Scholar
• Doherty J. E. The plasma digoxin controversy. Lancet 1972; 1: 536
   Google Scholar
• Morrison J., Killip R. Serial serum digitalis levels in patients with acute myocardial infarction. Clin. Res. 1971; 19: 353
   Google Scholar
• Lipp H., Denes P., Gambetta M., Resnekov L. Hemodynamic response to acute intravenous digoxin in patients with recent myocardial infarction and coronary insufficiency with and without heart failure. Chest 1973; 63: 862
   PubMedGoogle Scholar
• Haft J. I., Shahabadi A. E., Fano A. Clinical experience with ouabain administered in small divided doses in the monitored patient. Chest 1973; 63: 868
   PubMedGoogle Scholar
• Reicansky I., Conradson T. B., Holmberg S., Ryd E. N. L., Waldenstr O. M. A., Wennerblom B. The effect of intravenous digoxin on the occurrence of ventricular tachycardia in acute myocardial infarction in man. Am. Heart J. 1976; 91: 705
   PubMedGoogle Scholar
• Lown B., Klein M. D., Barr I., Hagemeijer F., Kosowsky B. D., Garrison H. Sensitivity to digitalis drugs in acute myocardial infarction. Am. J. Cariol. 1972; 30: 388
   PubMed Web of Science ®Google Scholar
• Hodges M., Friesinger G. C., Riggins R. C., Dagenais J. R. Effects of intravenously administered digoxin on mild left ventricle failure in acute myocardial infarction in man. Am. J. Cardiol. 1972; 29: 749
   PubMed Web of Science ®Google Scholar
• Hood W. B., McCarthy B., Lown B. Myocardial infarction following coronary ligation in dogs: hemodynamic effects of isopioterenol and acetyl strophanthidin. Circ. Res. 1967; 21: 191
   PubMedGoogle Scholar
• Thompson A. J., Hargis J., Murphy M. L., Doherty J. E. Tritiated digoxin. XX. Tissue distribution in experimental myocardial infarction. Am. Heart J. 1974; 88: 319
   PubMedGoogle Scholar
• Morrison J., Killip T. Hypoxemia and digitalis toxicity in patients with chronic lung disease. Circulation 1971; 44(Suppl. 2[Abstr.])2
   Google Scholar
• Seller R. H., Cangiano J., Kim K. E., Mendelssohn S., Brest A. N., Swartz C. Digitalis toxicity and Hypomagnesemia. Am. Heart J. 1970; 79: 57
   PubMed Web of Science ®Google Scholar
• Beller G. A., Hood W. B., Jr., Smith T. W., Abelmann W. H., Wacker W. E. Correlation of serum magnesium levels and cardiac digitalis intoxication. Am. J. Cardiol. 1974; 33: 225
   PubMedGoogle Scholar
• Sampson J. J., Albertson E. C., Kondo B. The effect on man of potassium administration in relation to digitalis glycosides, with special reference to blood serum potassium, the electrocardiogram, and ectopic beats. Am. Heart J. 1943; 26: 164
   Google Scholar
• Lubash G. D., Cohen B. D., Braveman W. D., Rubin A. L., Luckey E. H. Electrocardiographic changes during hemodialysis with the artificial kidney. II. Treatment of digitalis intoxication. Circulation 1959; 19: 552
   PubMed Web of Science ®Google Scholar
• Callahan E. J., Fran N. R., Draus H., Ellis L. B. Clinical use of cation exchange resins in the treatment of congestive heart failure. Am. J. Med. Sci. 1952; 223: 117
   PubMedGoogle Scholar
• Marcus F. I. Metabolic factors determining digitalis dosage in man. Basic and Clinical Pharmacology of Digitalis, B. H. Marks, A. M. Weissler. Charles C Thomas, Springfield, Ill 1972
   Google Scholar
• Steiness E., Olesen K. H. Cardiac arrhythmia induced by hypokalemia and potassium loss during maintenance digoxin therapy. Br. Heart J. 1976; 38: 167
   PubMedGoogle Scholar
• Binnion P. F. The plasma digoxin controversy. Lancet 1972; 1: 535
   Google Scholar
• Binnion P. F. Hypokalemia and digoxin-induced arrhythmias. Lancet 1975; 1: 343
   PubMedGoogle Scholar
• Poole-Wilson P. A., Hall R., Cameron I. R. Hypokalemia, digitalis and arrhythmias. Lancet 1975; 1: 575
   PubMedGoogle Scholar
• Shapiro W. Correlative studies of serum digitalis levels and arrhythmias of digitalis intoxication. Am. J. Cardiol., in press
   Google Scholar
• Church G., Schamroth L., Schwartz N. H., Marriott H. J. L. Deliberate digitalis poisoning: a comparison of the toxic effects of 4 glycoside preparations. Ann. Intern. Med. 1962; 57: 946
   PubMed Web of Science ®Google Scholar
• Smith T. W., Willerson J. T. Suicidal and accidental digoxin ingestion. Report of 5 cases with serum digoxin level correlations. Circulation 1971; 44: 29
   PubMed Web of Science ®Google Scholar
• Butler V. P., Jr. Digoxin: immunologic approaches to measurement and reversal of toxicity. N. Engl. J. Med. 1970; 283: 1150
   PubMed Web of Science ®Google Scholar
• Curd J., Smith T. W., Jaton J. C., Haber E. The isolation of digoxin-specific antibody and its use in reversing the effects of digoxin. Proc. Natl. Acad. Sci. U.S.A. 1971; 58: 2401
   Google Scholar
• Watson J. F., Butler V. P., Jr. Biologic activity of digoxin-specific antisera. J. Clin. Invest. 1972; 51: 638
   PubMed Web of Science ®Google Scholar
• Gardner J. D., Kilno D. R., Swartz T. J., Butler V. P., Jr. Effects of digoxin specific antibodies on accumulation and binding and digoxin by human erythrocytes. J. Clin. Invest. 1973; 52: 1820
   PubMed Web of Science ®Google Scholar
• Butler V. P., Jr., Watson J. F., Schmidt D. H., Gardener J. D., Mandel W. J., Skelton C. L. Reversal of the pharmacological and toxic effects of cardiac glycosides by specific antibodies. Pharmacol. Rev. 1973; 25: 239
   PubMed Web of Science ®Google Scholar
• Butler V. P., Jr., Schmidt D. H., Smith T. W., Haber E., Raynor B. D., Demartini P. Effects of sheep digoxin-specific antibodies and their fab fragments on digoxin pharmacokinetics in dogs. J. Clin. Invest. 1977; 59: 345
   PubMed Web of Science ®Google Scholar
• Smith T. W., Haber E., Yeatman L., Butler V. P., Jr. Reversal of advanced digoxin intoxication with fab fragments of digoxin-specific antibodies. N. Engl. J. Med. 1976; 294: 797
   PubMed Web of Science ®Google Scholar
• Hobson J. D., Zettner A. Digoxin serum half-life following suicidal digoxin poisoning. JAMA 1973; 223: 147
   PubMed Web of Science ®Google Scholar
• Hobson J. D., Zettner A. Digoxin serum half-life following suicidal digoxin poisoning. JAMA 1973; 223: 1947
   Google Scholar
• Reza M. J., Kovick R. B., Shine K. I., Perce M. L. Massive intravenous digoxin overdose. N. Engl. J. Med. 1974; 291: 777
   PubMed Web of Science ®Google Scholar
• Dimaio V. J. M., Garriott J. C., Putnam R. Digoxin concentrations in postmortem specimens after overdose and therapeutic use. J. Forensic Sci. 1975; 20: 340
   PubMedGoogle Scholar
• Bertler A., Gustafson A., Redfors A. Massive digoxin intoxication. Report of 2 cases with pharmacokinetic correlations. Acta Med. Scand. 1973; 194: 245
   PubMedGoogle Scholar
• Withering W. Letter to Hall Jackson, 1786; as cited by Carroll, D., Introduction of digitalis into North America. N. Engl, J. Med. 1946; 235: 808
   PubMedGoogle Scholar