Dopamine β-Hydroxylase in Health and Disease

References

• Blascfako H., Hagen J. M., Hagen P. Mitochondrial enzymes and chromaffin granules. J. Physiol. 1957; 139: 316
   Google Scholar
• Blaschko H. The specific action of 1-dopa-decarboxylase. J. Physiol. 1939; 96: 50
   Google Scholar
• Holtz P., Heize R., Ludtke K. Fermentation Abbau von 1-dioxyphenylalamin (dopa) durch miere. Arch. Exp. Pathol. Pharmakol. 1938; 191: 87
   Google Scholar
• Blaschko H. Activity of 1 (-) dopa decarboxylase. J. Physiol. 1942; 101: 337
   PubMedGoogle Scholar
• Kirshner N. Pathway of noradrenaline formation from DOPA. J. Biol. Chem. 1957; 226: 821
   Google Scholar
• Stjarne L., Roth R. H., Lishajko F. Noradrenaline formation from dopamine in isolated subcellular perticles from bovine splenic nerve. Biochem. Pharmacol. 1967; 16: 1729
   Google Scholar
• Blaschko H. Biochemical principles in relation to hypotensive-drug action. Hypotensive Drugs, M. Harrington. Pergamon Press, London 1956
   Google Scholar
• Levin E. Y., Levenberg B., Kaufman S. The enzymatic conversion of 3,4-Dihydroxyphenyle-thylamine to norepinephrine. J. Biol. Chem. 1960; 235: 7
   Google Scholar
• Friedman S., Kaufman S. 3,1-dihydroxyphenylethylamine β-hydroxylase. J. Biol. Chem. 1965; 240: 4763
   Google Scholar
• Goldstein M., Lauber E., McKereghan M. R. Studies on the purification and characterization of 3,4-dihydroxyphenylethylamine β-hydroxylase. J. Biol. Chem. 1965; 240: 5
   Google Scholar
• Foldes A., Jeffrey P. L., Preston B. N., Austin L. Dopamine β-hydroxylase of bovine adrenal medullae. Biochem. J. 1972; 126: 1209
   Google Scholar
• Wallace E. F., Krantz M. J., Lovenberg W. Dopamine β-hydroxylase: a tetrameric glycoprotein. Proc. Nat. Acad. Sci. 1973; 70: 2253
   Google Scholar
• Craine J. E., Daniels G. H., Kaufman S. Dopamine β-hydroxylase: The subunit structure and anion activation of the bovine adrenal enzyme. J. Biol. Chem. 1973; 248: 7838
   Google Scholar
• Aunis D., Miras-Portugal M-T., Mandel P. Bovine adrenal medullary dopamine β-hydroxylase: purification of, affinity chromatography, kinetic studies and presence of essential histidyl residues. Biochim. Biophys. Acta 1973; 327: 313
   Google Scholar
• Aunis D., Miras-Portugal M-T., Mandel P. Bovine adrenal medullary dopamine β-hydroxylase: studies on the structure. Biochim. Biophys. Acta 1974; 365: 259
   Google Scholar
• Rush R. A., Thomas P. E., Kindler S. H., Udenfriend S. The interaction of dopamine β-hydroxylase with Concanavalin A and its use in enzyme purification. Biochem. Biophys. Res. Commun. 1974; 57: 1301
   Google Scholar
• Ljönes T., Skotland T., Flatmark T. Purification of characterization of dopamine β-hydroxylase from bovine adrenal medulla. Eur. J. Biochem. 1976; 61: 525
   Google Scholar
• Smith A. D., Winkler H. A simple method for the isolation of adrenal chromaffin granules on a large scale. Biochem. J. 1967; 103: 480
   PubMedGoogle Scholar
• Grzanna R., Coyle J. T. Rat adrenal dopamine β-hydroxylase: purification and immunologic characteristics. J. Neurochem. 1976; 27: 1091
   Google Scholar
• Rush R. A., Geffen L. B. Radioimmunoassay and clearance of circulating dopamine β-hydroxylase. Circ. Res. 1972; 31: 444
   PubMedGoogle Scholar
• Rush R. A., Thomas P. E., Udenfriend S. Measurement of human dopamine β-hydroxylase in serum by homologous radioimmunoassay. Proc. Natl. Acad. Sci. 1975; 12: 750
   Google Scholar
• Goldstein M. Enzymes involved in the catalysis of catecholamine biosynthesis. Methods in Neurochemistry, N. Marks, R. Rodright. Plenum Press, New York 1972; 317
   Google Scholar
• Stone R. A., Kirshner N., Reynolds J., Vanaman T. C. Purification and properties of dopamine β-hydroxylase from human phaeochromocytoma. Mol. Pharmacol. 1974; 10: 1009
   Google Scholar
• Miras-Portugal M. T., Aunis D., Mandel P. Human serum dopamine β-hydroxylase; purification, molecular weight, presence of sugars and kinetic properties. Biochimie 1975; 57: 669
   Google Scholar
• Miras-Portugal M. T., Aunis D., Mandel P. Structural study of dopamine β-hydroxylase purified from human serum. C.R. Acad. Sci. 1975; 280: 479
   Google Scholar
• Lovenberg W., Goodwin J. S., Wallace E. F. in. Neurobiological Mechanism of Adaption and Behaviour, A. J. Mandel, 1975; 77, Raven Press
   Google Scholar
• Ikeno T., Kashimoto S., Kuzuya H., Nagatsu T. Purifications and properties of human serum dopamine β-hydroxylase. Mol. Cell. Biochem. 1977; 18: 117
   Google Scholar
• Terland O., Flatmark T. Ascorbate as a natural constituent of chromaffin granules from bovine adrenal medulla. FEBS Lett. 1975; 59: 52
   PubMed Web of Science ®Google Scholar
• Wallace E. F., Lovenberg W. Studies on the carbohydrate moiety of dopamine β-hydroxylase: interaction of the enzyme with Concanavalin A. Proc. Natl. Acad. Sci. 1974; 71: 3217
   Google Scholar
• Sharon N., Lis M. Lectins: cell-agglutinating and sugar-specific proteins. Science 1972; 177: 949
   PubMed Web of Science ®Google Scholar
• Aunis D., Bouclier M., Pescheloche M., Mandel P. Properties of membrane-bound dopamine β-hydroxylase in chromaffin granules from bovine adrenaj medulla. J. Neurochem. 1977; 29: 439
   Google Scholar
• Hortnagl H., Winkler H., Lochs H. Membrane proteins of chromaffin granules. Biochem J. 1972; 129: 187
   Google Scholar
• Hortnagl H., Winkler H., Schopf J. A. L., Hohen Wallner W. Membranes of chromaffin granules. Isolation and partial characterisation of two proteins. Biochem. J. 1971; 122: 299
   Google Scholar
• Helle K. B., Lagercrantz H., Stjarne L. Biochemistry of catecholamine storage: some similarities between whole sympathetic nerve trunk vesicles and the membranes of adrenomedullary vesicles. Acta Physiol. Scand. 1971; 81: 565
   Google Scholar
• Rush R. A. Mechanism of Transmitter Release from Sympathetic Neurones, Ph.D. thesis, Monash University,Melbourne, Australia 1972
   Google Scholar
• Hogue-Angeletti R. A. Nonidentity of chromogranin A and dopamine β-monooxygenase. Arch. Biochem. Biophys. 1977; 184: 364
   PubMedGoogle Scholar
• Helle K. B. Biochemical studies of the chromaffin granule. I. Biochim. Biophys. Acta 1971; 80
   Google Scholar
• Helle K. B. Biochemical studies of the chromaffin granule. II. Biochim. Biophys. Acta 1971; 94
   Google Scholar
• Aunis D., Allard D., Miras-Portugal M. T., Mandel P. Bovine adrenal medullary chromogranin A: studies on the structure and further evidence for identity with dopamine β-hydroxylase subunit. Biochim. Biophys. Acta 1975; 393: 284
   Google Scholar
• Foldes A., Jeffrey P. L., Preston B. N., Austin L. Some physical properties of bovine adrenal medullary dopamine β-hydroxylase. J. Neurchem. 1973; 20: 1431
   Google Scholar
• Winkler H. The composition of adrenal chromaffin granules: an assessment of contraversial results. Neuroscience 1976; 1: 68
   Google Scholar
• Goldstein M., Jon T. H., Garvey T. Q. Kinetic studies of the enzymatic dopamine β-hydroxylation reaction. Biochemistry 1968; 27: 24
   Google Scholar
• Kaufman S., Bridgers W. F., Eisenberg F., Friedman S. The source of oxygen in the phenylalanine hydroxydase and the DBH catalyzed reactions. Biochem. Biophys. Res. Commun. 1962; 9: 497
   Google Scholar
• Henry J. P., Hirata F., Hayaishi O. Superoxide anion as a cofactor of DBH. Biochem. Biophys. Res. Commun. 1978; 81: 1091
   Google Scholar
• Dilberto E. J., Kaufman S. Lack of inhibition of dopamine β-hydroxylase by superoxide dismutase. Superoxide and Superoxide Dismutase Micheison, M. A, J. M. McCord, I. Firdovitch. Academic Press, London 1977; 407
   Google Scholar
• Kato T., Wakui Y., Nagatsu T., Ohnishi T. An improved dualwavelength spectrophotometric assay for DBH. Biochem. Pharmacol. 1978; 27: 829
   PubMed Web of Science ®Google Scholar
• Creveling C. R., Daly J. W., Witkop B., Udenfriend S. Substrates and inhibitors of dopamine β-oxidase. Biochim. Biophys. Acta 1962; 64: 125
   PubMed Web of Science ®Google Scholar
• Nagatsu T., Udenfriend S. Photometric assay of dopamine β-hydroxylase activity in human blood. Clin. Chem. 1972; 18: 980
   PubMed Web of Science ®Google Scholar
• Spector S., Sjoerdsma A., Zaltzman-Nirenberg P., Levitt M., Udenfriend S. Norepinephrine synthesis from tyrosine-C14 in isolated perfused guinea-pig heart. Science 1963; 139: 1299
   Google Scholar
• Levitt M., Spector S., Sjoerdsma A., Udenfriend S. Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart. J. Pharmacol. Exp. Ther. 1965; 148: 1
   PubMed Web of Science ®Google Scholar
• Nagatsu T., Kuzuya M., Hidaka H. Inhibition of dopamine β-hydroxylase by sulphydryl compounds and the nature of the natural inhibitors. Biochem. Biophys. Acta 1967; 139: 319
   PubMed Web of Science ®Google Scholar
• Molinoff P. B., Orcutt J. C. Dopamine β-hydroxylase and the regulation of catecholamine biosynthesis. Frontiers in Catecholamine Research, E. Usdin, S. H. Snyder. Pergamon Press, New York 1973; 195
   Google Scholar
• Orcutt J. C., Molinoff P. B. Endogenous inhibitors of dopamine β-hydroxylase: separation of multiple forms and access to the enzyme. J. Pharmacol. Exp. Ther. 1977; 590
   Google Scholar
• Chubb I. W., Preston B. N., Austin L. Partial characterization of a naturally occuring inhibitor of DBH. Biochem. J. 1969; 243
   Google Scholar
• Duch D. S., Kirshner N. Isolation and partial characterization of an endogenous inhibitor of dopamine β-hydroxylase. Biochim. Biophys. Acta 1971; 628
   Google Scholar
• Nikodijevic B., Creveling C. R., Udenfriend S. Inhibition of dopamine β-oxidase in vivo by benzyloxyamine and benzylhydrazine analogs. J. Pharmacol. Exp. Ther. 1963; 140: 224
   Google Scholar
• Stromberg U., Svensson T. H.L-Dopa. induced effects on motor activity in mice after inhibition of dopamine-beta-hydroxylase. Psychopharmacologia 1971; 19: 53
   Google Scholar
• Hidaka H., Asano T., Takemoto N. Analogues of fusaric (5-butylpicolinic) acid as potent inhibitors of dopamine β-hydroxylase. Mol. Pharmacol. 1973; 9: 172
   Google Scholar
• Hidaka H., Hara F., Harada N., Hashizume Y., Yano M. Selective inhibition of dopamine β-hydroxylase in the peripheral tissues by 5-dimethyldithiocarbamylpicolinic acid; its effect on stress-induced ulcer, ethanol-induced sleep and blood pressure. J. Pharmacol. Exp. Ther. 1974; 191: 384
   Google Scholar
• Nagatsu T., Hidaka H., Kuzuya H., Takeya K. Inhibition of dopamine β-hydroxylase by fusaric acid (5-butylpicolinic acid) in vitro and in vivo. Biochem. Pharmacol. 1970; 19: 33
   Google Scholar
• Kirshner N. Uptake of catecholamines by a particulate fraction of the adrenal medulla. Science 1962; 237: 2311
   Google Scholar
• Pisano J. J., Creveling C. R., Udenfriend S. Enzymatic conversion of p-tyramine to p-hydroxyphenylethanolamine(norsynephrin). Biochim. Biophys. Acta 1960; 43: 56
   Google Scholar
• Weinshilboum R., Axelrod J. Serum dopamine β-hydroxylase: decrease after chemical sympathectomy. Science 1971; 173: 931
   PubMed Web of Science ®Google Scholar
• Jon T. H., Ross R. A., Reis D. J. A simple and sensitive assay for dopamine β-hydroxylase. Anal. Biochem. 1974; 62: 248
   Google Scholar
• Ebstein R. P., Park D. H., Freedman L. S., Levitt S. M., Ohuchi T., Goldstein M. A radioimmunoassay of human circulatory dopamine β-hydroxylase. Life Sci. 1973; 13: 769
   Google Scholar
• Rush R. A., Kindler S. H., Udenfriend S. Solid-phase radioimmunoassay on polystyrene beads and its application to dopamine β-hydroxylase. Clin. Chem. (N. Y.) 1975; 2l: 148
   Google Scholar
• Rush R. A., Udenfriend S. The presence of antibodies to human DBH in commercially available antisera. Biochem. Biophys. Res. Commun. 1974; 61: 685
   Google Scholar
• Kashimoto T., Park D., Ebstein R. P., Goldstein M., Levitz M., Yaverbaum S. A radioimmunoassay for dopamine β-hydroxylase using a glass-bound antibody. Experientia 1974; 30: 1363
   Google Scholar
• Kato T., Kuzuya H., Nagatsu T. A simple and sensitive assay for dopamine β-hydroxylase: activity by dual-wavelength spectrophotometry. Biochem. Med. 1974; 10: 320
   PubMed Web of Science ®Google Scholar
• Ohnishi T. An improved dual-wavelength spectrophotometric assay for DBH. Biochem. Pharmacol. 1978; 27: 829
   Google Scholar
• Nagatsu T., Thomas P., Rush R. A., Udenfriend S. A radioassay for dopamine β-hydroxylase activity in rat serum. Anal. Biochem. 1973; 55: 615
   Google Scholar
• Reis D. J., Joh T. H., Ross R. A., Picket V. M. Reserpine selectively increases tyrosine hydroxylase and dopamine β-hydroxylase enzyme protein in central noradrenergic neurons. Brain Res. 1974; 81: 380
   Google Scholar
• Nagatsu I., Kondo Y., Kata T., Nagatsu T. Retrograde axoplasmic transport of inactive dopamine β-hydroxylase in sciatic nerves. Brain Res. 1976; 116: 277
   Google Scholar
• Kirshner N., Schanberg S. M., Sage H. J. Homospecific activity of serum and tissue DBH. Life Sci. 1975; 17: 423
   Google Scholar
• Olukotun A., Dunnette J., Weinshilboum R. Dissociation of changes in enzymatic and immunoreactive rat serum DBH during growth and development. J. Pharmacol. Exp. Ther. 1977; 201: 375
   Google Scholar
• Hoeldtke R., Kaufman S. A tritium-release in vivo assay of DBH activity in sympathetic neurons. Biochem. Pharmacol. 1978; 27: 2499
   Google Scholar
• Rush R. A., Kindler S. H., Udenfriend S. Homospecific activity, an immunologic index of enzyme homogeneity; changes during the purification of dopamine β-hydroxylase. Biochem. Biophys. Res. Commun. 1975; 61: 38
   Google Scholar
• Klein R. L., Kirksey D. F., Rush R. A., Goldstein M. Preliminary estimates of the DBH content and activity in purified noradrenergic vesicles. J. Neurochem. 1977; 28: 81
   Google Scholar
• Potter L. T., Axelrod J. Subcellular localization of catecholamines in tissues of the rat. J. Pharmacol. Exp. Ther. 1963; 142: 291
   PubMed Web of Science ®Google Scholar
• Geffen L. B., Livett B. G. Synaptic vesicles in sympathetic neurons. Physiol. Rev. 1971; 51: 78
   Google Scholar
• Geffen L. B., Jarrott B. Cellular aspects of catecholaminergic neurons. Handbook of Physiology. American Physiological Society, Washington, DC 1978; Vol. II.: 15, 521
   Google Scholar
• Frydman R., Geffen L. B. Depletion and repletion of adrenal dopamine β-hydroxylase after reserpine; immunohistochemical and fine structural correlates. J. Histochem. Cytochem. 1973; 21: 166
   Google Scholar
• Ngai S. H., Dairman W., Marchelle ML, Spector S. Dopamine β-hydroxylase in dog lymph — effect of sympathetic activation. Life Sci. 1974; 14: 2431
   Web of Science ®Google Scholar
• de Potter W. P., Pham-Huu Chanh C, de Smet F., de Schaepdryver A. F. The presence of dopamine β-hydroxylase in the cerebrospinal fluid of rabbits and its increased concentration after stimulation of peripheral nerves and cold stress. Neuroscience 1976; 1: 523
   Google Scholar
• Goldstein D. J., Cubeddu L. X. Dopamine β-hydroxylase activity in human cerebrospinal fluid. J. Neurochem. 1976; 26: 193
   Google Scholar
• Coyle J. T., Wooten G. F., Axelrod J. Evidence for extranoradrenergic gopamine β-hydroxylase activity in rat salivary gland. J. Neurochem. 1974; 22: 923
   Google Scholar
• Wooten G. F., Jacobwitz D. M., Saavedra J. M., Axelrod J. Localization of extraneuronal dopamine β-hydroxylase in rat salivary gland by immunofluorescence histochemistry. J. Neurochem. 1975; 24: 1107
   Google Scholar
• Grzanna R., Coyle J. T. Dopamine β-hydroxylase in rat submandibular ganglion cells which lack norepinephrine. Brain Res. 1978; 151: 206–214
   PubMed Web of Science ®Google Scholar
• Smith W. J., Kirshner N. A specific soluble protein from the catecholamine storage vesicles of bovine adrenal medulla. (1). Purification and chemical characterization. Motec. Pharmacol. 1967; 3: 52
   PubMedGoogle Scholar
• Kirshner N., Viveros H. Quantal aspects of the secretion of catecholamines and dopamine β-hydroxylase from the adrenal medulla, in New Aspects of Storage and Release Mechanisms of Catecholamines, H. Schumann, G. Kroneberg. Springer-Verlag, Berlin 1970; 78
   Google Scholar
• Ciaranello R. D., Wooten G. F., Axelrod J. Regulation of DBH in rat adrenal glands. J. Biol. Chem. 1975; 250: 3204
   Google Scholar
• Chubb I. W., de Potter W. P., de Schaepdryver A. F. Influence of electrical stimulation on the subcellular distribution of DBH in dog spleen. Experientia 1972; 23: 293
   Google Scholar
• Bisby M. A., Fillenz M., Smith A. D. Evidence for the presence of dopamine β-hydroxylase in both populations of noradrenaline storage vesicles in sympathetic nerve terminals of the rat vas deferens. J. Neurochem. 1973; 20: 245
   Google Scholar
• De Potter W. P., Smith A. D., de Schaepdryver A. F. Subcellular fractionation of splenic nerve: ATP; chromogranin and dopamine β-hydroxylase in noradrenergic 61 vesicles. Tissue Cell 1970; 2: 529
   Google Scholar
• Lagercrantz H. On the composition and function of large dense cored vesicles in sympathetic nerves. Neuroscience 1976; 1: 81
   PubMed Web of Science ®Google Scholar
• Hortnagl H., Hortnagl H., Winkler H. Bovine splenic nerve: characterization of noradrena-line-containing vesicles and other cell organelles by density gradient centrifugation. J. Physiol. 1969; 205: 103
   Google Scholar
• Hortnagl H., Hortnagl H., Winkler H. Bovine splenic nerve: characterization of noradrena-line-containing vesicles and other cell organelles by density gradient centrifugation. J. Physiol. 1969; 205: 103
   Google Scholar
• de Potter W. P. Noradrenaline storage particles in splenic nerve. Philos. Trans. R. Soc. London 1971; 261: 313
   Google Scholar
• Kirksey D. P., Klein R. L., Thoreson-Klein A., White H. B. Latency of dopamine β-hydroxylase in purified noradrenergic vesicles. Neuroscience 1977; 2: 621
   Google Scholar
• Smith A. D., de Potter W. P., de Schaepdryver A. P. Subcellular fractionation of bovine splenic nerves. Arch. Int. Pharmacodyn Ther. 1969; 179: 495
   Google Scholar
• Geffen L. B., Livett B. G., Rush R. A. Immunohistochemical localization of chromogranins in sheep sympathetic neurones and their release by nerve impulses. New Aspects of Storage and Release Mechanisms of Catecholamines, H. J. Schumann, G. Kroneberg. Springer-Verlag, Berlin 1970; 58
   Google Scholar
• Ross S. B., Weinshilboum R., Molinoff P. B., Vessell E. S., Axelrod J. Electrophoretic properties of dopamine β-hydroxylase in neural tissues from three species. Mol. Pharmacol. 1972; 8: 50
   PubMed Web of Science ®Google Scholar
• Kirshner N., Kirshner A. G. Chromogranin A, DBH and secretion from the adrenal medulla. Philos. Trans. R. Soc. London Ser. B 1971; 26l: 279
   Google Scholar
• Viveros O. H., Arqueros L., Connett R. J., Kirshner N. Mechanism of secretion from the adrenal medulla. IV. The fate of the storage vesicles following insulin and reserpine administration. Mol. Pharmacol. 1969; 5: 69
   Google Scholar
• Viveros O. H., Arqueros L., Kirschner N. Mechanism of secretion from the adrenal medulla. VII. Effect of insulin administration on the buoyant density, dopamine β-hydroxylase and catecholamine content of adrenal storage vesicles. Mol. Pharmacol. 1971; 7: 111
   Google Scholar
• Jacobowitz D. M., Ziegler M. G., Thomas J. A. In vivo uptake of antibody to dopamine β-hydroxylase into sympathetic elements. Brain Res. 1975; 91: 165
   PubMedGoogle Scholar
• Rush R. A., Costa M., Furness J. B., Geffen L.B. Changes in tyrosine hydroxylase and dopamine β-hydroxylase activities during degeneration of noradrenergic axons produced by antibodies to dopamine β-hydroxylase. Neurosci. Lett. 1976; 3: 209
   Google Scholar
• Costa M., Rush R. A., Furness J. B., Geffen L. B. Histochemical evidence for degeneration of peripheral noradrenergic axons following intravenous injection of antibodies to dopamine β-hydroxylase. Neurosci. Lett. 1976; 3: 201
   Google Scholar
• Gibb J. W., Spector S., Udenfriend S. Production of antibodies to dopamine β-hydroxylase of bovine adrenal medulla. Mol. Pharmacol. 1967; 3: 5
   Google Scholar
• Geffen L. B., Rush R. A. Immunological studies of DBH as a marker for adrenergic synaptic vesicles. Front. Catechol. Res. 1973; 483
   Google Scholar
• Livett B. G. Immunohistochemical localization of nervous system specific proteins and peptides. Int. Rev. Cytol. 1978; 56
   Google Scholar
• Hartman B. K., Udenfriend S. Immunofluorescent localization of dopamine β-hydroxylase in tissues. Mot. Pharmacol. 1970; 6: 85
   PubMed Web of Science ®Google Scholar
• Hartman B. K. Immunofluorescence of dopamine β-hydroxylase. J. Histochem. Cytochem. 1973; 21: 312
   PubMedGoogle Scholar
• Goldstein ML, Fuxe K., Hokfelt T. Multiple forms of localization of enzymes. Pharmacol. Rev. 1978; 34
   Google Scholar
• Jones E. G., Hartman B. K. Recent advances in neuroanatomical methodology. Ann. Rev. Ncurosci. 1978; 1: 215
   PubMedGoogle Scholar
• Hokfelt T., Fuxe K., Goldstein M., Joh T. H. Immunohistochemical localization of three catecholamine synthesizing enzymes: aspects on methodology. Histochemie 1973; 23: 231
   Google Scholar
• Sternberger L. A. Immunocytochemistry, immunohistochemistry. Foundations of Immunology Series. Prentis-Hail, New Jersey 1974
   Google Scholar
• Grzanna R., Morrison J. H., Coyle J. T., Molliver M. E. The immunohistochemical demonstration of noradrenergic neurons in the rat brain: the use of homologous antiserum to DBH. Ncurosci. Lett. 1977; 4: 127
   Google Scholar
• Grzanna R., Molliver M. E., Coyle J. T. Visualization of central noradrenergic neurons in thick sections by the unlabeled antibody method: A transmitter specific golgi image. Proc. Natl. Acad. Sci. 1978; 75: 2502
   Google Scholar
• Pickel V. M., Joh T. H., Reis D. J. Monoamine-synthesizing enzymes in central dopaminergic noradrenergic and serotonergic neurons. Immunocytochemical localization by light and electron microscopy. J. Histochem. Cytochem. 1976; 24: 792
   PubMed Web of Science ®Google Scholar
• Swanson L. W., Hartman B. K. The central adrenergic system: an immunofluorescence study of the localization of cell bodies and their efferent connections in the rat, utilizing dopamine β-hydroxylase as a marker. J. Comp. Neurol. 1975; 163: 467
   PubMed Web of Science ®Google Scholar
• Pickel V. M., Joh T. H., Reis D. J. Monoamine-synthesizing enzymes in central dopaminergic noradrenergic and serotongergic neurons. J. Histochem. Cytochem. 1976; 24: 792
   PubMed Web of Science ®Google Scholar
• Thomas J. A., van Orden L. S., Redick J. A. Immunological localization of DBH on the chromaffin granule membrane. J. Psychiatr. Res. 1974; 11: 317
   PubMed Web of Science ®Google Scholar
• Holzman P., Goldstein M., Freedman L., Teichberg S., Peterson E., Lele K. First steps towards electron microscope immunohistochemical localization of dopamine β-hydroxylase (DBH) in sympathetic nervous tissue. J. Histochem. Cytochem. 1974; 22: 295
   Google Scholar
• Rush R. A., Millar T. J., Chubb I. W., Geffen L. B. Use of DBH antibodies in study of vesicle dynamics. Catecholamines: Basic and Clinical Frontiers, E. Usdin, I. J. Kopin, J. Barchas. Pergamon Press, New York 1979; 331
   Google Scholar
• Lundberg J., Bylock A., Goldstein M., Hansson H., Dahlstrom A. Ultrastructural localization of dopamine β-hydroxylase in never terminals of the rat brain. Brain Res. 1977; 120: 549
   Google Scholar
• Cimarusti D. L., Saito K., Vaughn J. E., Barber R., Roberts E., Thomas P. E. Immunohistochemical localization of DBH in rat locus coeruleus and hypothalamus. Brain Res. 1979; 162: 55
   PubMed Web of Science ®Google Scholar
• Axeirod J. Dopamine β-hydroxylase: regulations of its synthesis and release from never terminals. Pharmacol. Rev. 1972; 24: 2
   Google Scholar
• Livett B. G. Axonal transport and neuronal dynamics: contributions to the study of neuronal connectivity. Int. Rev. Physiol. 1976; 10: 37
   Google Scholar
• Winkler H. The biogenesis of adrenal chromaffin granules. Neuroscience 1977; 2: 657
   PubMed Web of Science ®Google Scholar
• Droz B., Koenig H. L. Dynamic condition of protein in axons and axon terminals. Acta Neuropathol. 1971; 5: 109
   Google Scholar
• Laduron P., Belpaire F. Transport of noradrenaline and DBH in sympathetic nerves. Life Sci. 1968; 7: 1
   Google Scholar
• Geffen L. B., Livett B. G., Rush R. A. Immunological localization of chromogranins in sheep sympathetic neurons and their release by nerve impulses. J. Physiol. 1969; 204: 58
   Google Scholar
• Nagatsu I., Hartman B. K., Udenfriend S. The anatomical characteristics of DBH accumulation in ligated sciatic nerve. J. Histochem. Cytochem. 1974; 22: 1010
   Google Scholar
• Nagatsu I., Kondo Y. Studies on axonal flow of DBH and TOH in sciatic nerves by immunofluorescent and biochemical methods. Acta Histochem. Cytochem. 1975; 8: 279
   Google Scholar
• Nagatsu I. Localization of dopamine β-hydroxylase, in bovine adrenal gland and rat sciatic nerves by the improved enzyme immunocytochemical and enzyme-immunofluorescent methods. Acta Histochem. Cytochem. 1974; 7: 147
   Google Scholar
• Livett B. G., Geffen L. B., Rush R. A. Preliminary Communication, immunohistochemical evidence for the transport of DBH and a catecholamine binding protein in sympathetic nerves. Biochem. Pharmacol. 1969; 18: 923
   Google Scholar
• Jarrott B, Geffen L. B. Rapid axoplasmic transport of TOH in relation to other cytoplasmic constituents. Proc. Natl. Acad. Sci. 1972; 69: 3440
   Google Scholar
• Brimijoin S. Transport and turnover of dopamine β-hydroxylase in sympathetic nerves of the rat. J. Neurochem. 1973; 19: 2183
   Google Scholar
• Dairman W., Geffen L., Marchelle M. Axoplasmic transport of aromatic L-amino acid de carboxylase and dopamine β-hydroxylase in rat sciatic nerve. J. Neurochem. 1973; 20: 1617
   Google Scholar
• Brimijoin S., Capek P., Dyck P. J. Axonal transport of dopamine β-hydroxylase by human sural nerves in vitro. Science 1973; 180: 1295
   Google Scholar
• Coyle J. T., Wooten G. F. Rapid axonal transport of tyrosine hydroxylase and dopamine β-hydroxylase. Brain Res. 1972; 44: 701
   Google Scholar
• Wooten G. F., Coyle J. T. Axonal transport of catecholamine synthesizing and metabolizing enzymes. J. Neurochem. 1973; 20: 1361
   Google Scholar
• Grafstein B. Axonal transport: the intracellular traffic of the neuron. Handb. Physiol, J. M. Brookhart, V. B. Mountcastle, E. R. Kandel, S. R. Geiger. American Physiological Society, Washington, DC 1977; Vol. la: 691
   Google Scholar
• Oesch F., Otten U., Thoenen H. Relationship between the rate of axoplasmic transport and subcellular distribution of enzymes involved in the synthesis of norepinephrine. J. Neurochem. 1973; 20: 1691
   Google Scholar
• de Potter W. P., Chubb I. W. The turnover rate of noradrenergic vesicles. Biochem. J. 1971; 125: 375
   Google Scholar
• Brimijoin S., Helland L. Rapid retrograde transport of DBH as examined by the stop-flow technique. Brain Res. 1976; 102: 217
   Google Scholar
• Bisby M. A. Axonal transport. Gen. Pharmacol. 1976; 7: 387
   Google Scholar
• Fillenz M., Gagnon C, Stoeckel K., Thoenen H. Selective uptake and retrograde axonal transport of dopamine β-hydroxylase antibodies in peripheral adrenergic neurons. Brain Res. 1976; 114: 293
   PubMedGoogle Scholar
• Molinoff P. B., Brimijoin S., Weinshilboum R., Axelrod J. Neurally mediated increase in dopamine β-hydroxylase activity. Proc. Natl. Acad. Sci. 1970; 66: 453
   Google Scholar
• Kvetnansky R., Gewirtz G. P., Weise V. K., Kopin I.J. Catecholamine-synthesizing enzymes in the rat adrenal gland during exposure to cold. Am. J. Physiol. 1971; 220: 928
   PubMedGoogle Scholar
• Thoenen H., Angeletti P. U., Levi-Montalcini R., Kettler R. Selective induction by nerve growth factor of tyrosine hydroxylase and dopamine β-hydroxylase in the rat superior cervical ganglia. Proc. Natl. Acad. Sci. 1971; 68: 1598
   Google Scholar
• Fillenz M., West D. P. Changes in DBH and noradrenaline resulting from cold exposure. Experientia 1974; 30: 55
   Google Scholar
• Fillenz M., West D. P. Changes in vesicular dopamine β-hydroxylase resulting from transmitter release. J. Neurochem. 1974; 23: 411
   Google Scholar
• Weinshilboum R. M., Kvetnansky R., Axelrod J., Kopin I. J. Elevation of serum DBH activity with forced immobilization. Nature (London) New Biol. 1971; 230: 287
   Google Scholar
• Molinoff P. B., Brimijoin S., Axelrod J. Induction of dopamine β-hydroxylase and tyrosine hydroxylase in rat hearts and sympathetic ganglia. J. Pharmacol. Exp. Ther. 1972; 182: 1
   Google Scholar
• Thoenen H., Kettler R., Burkhard W., Saner A. Neuronally mediated control of enzymes involved in the synthesis of norepinephrine; are they regulated as an operational unit?. Arch. Pharmakoi. 1971; 270: 146
   Google Scholar
• Molinoff P. B., Brimijoin S., Axelrod J. Trans-synaptic induction of DBH in adrenergic tissues of the rat. Biochem. Soc. 1971; 18
   Google Scholar
• Thoenen H. Comparison between the effect of neuronal activity and nerve growth factor on the enzymes involved in the synthesis of norepinephrine. Pharmacol. Rev. 1973; 21: 3
   Google Scholar
• Hendry I. A. Control in the development of the vertebrate sympathetic nervous system. Reviews of Neuroscience, S. Ephreneis, I. J. Kopin. Raven Press, New York 1976; 2: 149
   Google Scholar
• Reis D. J., Ross R. A. Dynamic changes in brain dopamine β-hydroxylase activity during anterograde and retrograde reactions to injury of central noradrenergic axons. Brain Res. 1974; 57: 307
   Google Scholar
• Brimijoin S. Evidence that 6-OH-dopamine decreases synthesis of DBH in sympathetic ganglia. J. Pharmacol. Exp. Ther. 1972; 183: 298
   Google Scholar
• Giaranello R. D., Wooten G. F., Axelrod J. Regulation of rat adrenal DBH. II. Receptor interaction in the regulation of enzyme synthesis and degradation. Brain Res. 1976; 113: 349
   Google Scholar
• Zigmond R. E., Mackay A. V. P. Dissociation of stimulatory and synthetic phases in the induction of tyrosine hydroxylase. Nature (London) 1974; 247: 112
   Google Scholar
• Gagnon C, Schatz R., Otten U., Thoenen H. Synthesis, subcellular distribution and turnover of dopamine β-hydroxylase in organ cultures of sympathetic ganglia and adrenal medulla. J. Neurochem. 1976; 27: 1083
   Google Scholar
• Gagnon C, Otten U., Thoenen H. Dopamine β-hydroxylase in organ culture of rat adrenal medulla: synthesis, storage, release and trans-synaptic induction. Catecholamines and Stress, E. Usdin, R. Kvetnansky, I. J. Kopin, 1976; 305
   Google Scholar
• Goodman R., Otten U., Thoenen H. Organ culture of the rat adrenal medulla: a model system for the study of trans-synaptic enzyme reduction. J. Neurochem. 1975; 25: 423
   Google Scholar
• Blaschko H., Comline R. S., Schneider F. H., Silver M., Smith A. D. Secretion of a chromaffin granule protein, chromogranin, from the adrenal gland after splanchnic stimulation. Nature (London) 1967; 215: 58
   PubMed Web of Science ®Google Scholar
• Schneider F. H., Smith A. D., Winkler H. Secretion from the adrenal medulla: biochemical evidence for exocytosis. Br. J. Pharmacol. Chemother. 1967; 31: 94
   PubMed Web of Science ®Google Scholar
• Kirshner N., Sage H. J., Smith W. J. Mechanism of secretion from the adrenal medulla. Mol. J. Pharmacol. 1967; 3: 254
   Google Scholar
• Viveros O. H., Arqueros L., Kirshner N. Release of catecholamines and dopamine β-oxidase from the adrenal medulla. Life Sci. 1968; 7: 609
   Web of Science ®Google Scholar
• de Robertu E., vaz Ferreira A. Electron microscope study of the excretion of catechol-containing droplets in the adrenal medulla. Exp. Cell Res. 1957; 12: 568
   Google Scholar
• Douglas W. W. Stimulus secretion coupling: the concept and clues from chromaffin and other cells. Br. J. Pharmacol. 1968; 34: 451
   PubMed Web of Science ®Google Scholar
• Aunis D., Serck-Hanssen G., Helle K. B. Dopamine β-hydroxylase in perfusates of stimulated bovine adrenals: isolation and characterization of the release enzyme. Gen. Pharmacol. 1978; 9: 37
   Google Scholar
• Helle J., Serck-Hanssen G. Differential release of noradrenaline, adrenaline and DBH from bovine adrenal. J. Physiol. 1977; 275: 27
   Google Scholar
• Smith A. D., de Potter W. P., Moerman E. J., de Schaepdryver A. F. Release of dopamine β-hydroxylase and chromogranin A upon stimulation of the splenic nerve. Tissue Cell 1970; 2: 547
   PubMedGoogle Scholar
• Gewirtz G. P., Kopin I. J. Release of dopamine β-hydroxylase with norepinephrine during Cat splenic nerve stimulation. Nature (London) 1970; 227
   Google Scholar
• Weinshilboum R. M., Thoa N. B., Johnson D. G., Kopin I. J., Axelrod J. Proportional release of norepinephrine and DBH from sympathetic nerves. Science 1971; 174: 1349
   PubMed Web of Science ®Google Scholar
• Algate D. R., Leach G. D. H. DBH release following acute selective sympathetic nerve stimulation of the heart, spleen and mesentery. J. Pharm. Pharmacol. 1978; 30: 162
   Google Scholar
• de Potter W. P., Chubb I. W., Put A., de Schaepdryver A. F. Facilitation of the release of noradrenaline and DBH at low stimulation frequencies by β-blocking agents. Arch. Int. Pharmacodyn. Ther. 1971; 193: 191
   Google Scholar
• Cubeddu L. X., Barnes E. M., Langer S. Z., Weiner N. Release of norepinephrine and DBH by nerve simulation. I. J. Pharmacol. Exp. Ther. 1974; 190: 431
   Google Scholar
• Cubeddu L. X., Barnes E., Weiner N. Release of norepinephrine and dopamine β-hydroxylase by nerve stimulation. II. J. Pharmacol. Exp. Ther. 1974; 191: 444
   Google Scholar
• Cubeddu L. X., Weiner N. Nerve stimulation-mediated overflow of norepinephrine and DBH. III. J. Pharmacol. Exp. Ther. 1975; 192: 1
   Google Scholar
• Johnson D. G., Thoa N. B., Weinshilboum R., Axelrod J., Kopin I. J. Enhanced release of dopamine β-hydroxylase from sympathetic nerves by calcium and phenoxybenzamine and its reversal by prostaglandins. Proc. Natl. Acad. Sci. 1971; 6: 2227
   Google Scholar
• Thoa N. B., Wooten G. F., Axelrod J., Kopin I. J. Inhibition of release of dopamine β-hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B. Proc. Natl. Acad. Sci. 1972; 69: 520
   PubMed Web of Science ®Google Scholar
• Wooten G. F., Thoa N. B., Kopin I. J., Axelrod J. Enhanced release of dopamine β-hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3',5'-monophosphate and theophylline. Mol. Pharmacol. 1972; 9: 178
   Google Scholar
• Geffen L. B., Costa M., Rush R. A., Bridges D. Immune lesions of central noradrenergic neurons produced by dopamine β-hydroxylase (DBH) antibodies. Catecholamines: Basic and Clinical Frontiers, E. Usdin, J. Barchas. Pergamon Press, New York 1652; 1979
   Google Scholar
• Konig P., Hortnagl H., Kostron H, Sapinsky H., Winkler H. The arrangement of dopamine β-hydroxylase and chromomembrin B in the membrane of chromaffin granules. J. Neurochem. 1976; 27: 1539
   Google Scholar
• Ziegler M. G., Thomas J. A., Jacobowitz D. M. Retrograde axonai transport of antibody to dopamine β-hydroxylase. Brain Res. 1976; 104: 390
   PubMedGoogle Scholar
• Blessing W. W., Costa M., Geffen L. B., Rush R. A., Fink G. Immune lesions of noradrenergic neurones in rat central nervous system produced by antibodies to dopamine β-hydroxylase. Nature (London) 1977; 267: 36
   Google Scholar
• Furness J. B., Lewis S. Y., Rush R., Costa M., Geffen L. B. Involvement of complement in degeneration of sympathetic nerves after administration of DBH antibodies. Brain Res. 1977; 136: 67
   Google Scholar
• Furness J. B., Costa M., Rush R. A., Geffen L. B. Noradrenergic transmission in isolated guinea-pig intestine following in vivo administration of antibodies to DBH. Aust. J. Exp. Biol. Med. Sci. 1978, in press
   Google Scholar
• Lewis S. Y., Rush R. A., Geffen L. B. Biochemical effects on guinea-pig iris of local injections of DBH antibodies and Fab fragments. Brain Res. 1977; 134: 173
   Google Scholar
• Costa M., Geffen Rush L. B., R A., Bridges D., Blessing W. W., Heath J. W. Immuni lesions of central noradrenergic neurons produced by antibodies to DBH. Brain Res. 1979, in press
   Google Scholar
• Geffen L. B., Rush R. A., Costa M., Furness J. B., Blessing W. W. Use of dopamine β-hydroxylase antibodies in production of transmitter-specific immune lesions of noradrenergic nerves. Neurotoxins: Fundamental and Clinical Advances, I. W. Chubb, L. B. Geffen. Adelaid University Union Press, Adelaide 1979
   Google Scholar
• Geffen L. B., Rush R. A., Furness J. B. Autoimmune lesions of guinea-pig sympathetic noradrenergic nerves. Proc. Aust. Physiol. Pharmacol. Soc. 1978; 9: 133
   Google Scholar
• Black I. R., Petito C. K. Catecholamine enzymes in the degenerative neurological disease idiopathic orthostatic hypotension. Science 1976; 192: 910
   Google Scholar
• Weinshilboum R., Axelrod J. Serum dopamine-beta-hydroxylase activity. Circ. Res. 1971; 28: 307
   PubMed Web of Science ®Google Scholar
• Goldstein M., Freedman L. S., Bonnay M. An assay for dopamine β-hydroxylase activity in tissues and serum. Experientia 1971; 27: 632
   PubMedGoogle Scholar
• Laduron P. Scope and limitation in dopamine β-hydroxylase measurement. Biochem. Pharmacol. 1975; 24: 557
   Google Scholar
• Eshel Y., Korczyn A. D., Rabinowitz R., Gitter S. The stability of dopamine β-hydroxylase activity in blood samples. Clin. Chim. Acta 1978; 82: 291
   Google Scholar
• Geffen L. Serum dopamine β-hydroxylase as an index of sympathetic function. Life Sci. 1974; 14: 1593
   Google Scholar
• Wooten G. F., Cardon P. V. Plasma dopamine β-hydroxylase activity. Arch. Neurol. 1973; 28: 103
   Google Scholar
• Nagatsu T. Dopamine β-hydroxylase in blood and cerebrospinal fluid. Trends in Biochem. Sci. 1977; 2: 217
   Google Scholar
• Ross S. B., Weinshilboum R., Molinoff P. B., Vesell E. S., Axelrod J. Electrophoretic properties of DBH in several tissues from three species. Mol. Pharmacol. 1972; 8: 50
   PubMed Web of Science ®Google Scholar
• Wooten G. F., Ciaranello R. D. Proportionality between dopamine β-hydroxylase activity and immunoreactive protein concentration in human serum. Pharmacology 1974; 12: 272
   Google Scholar
• Weinshilboum R. M. Serum DBH activity and blood pressure. Mayo Clin. Proc. 1977; 52: 374
   Google Scholar
• Kirshner N., Schanberg S. M., Sage H. J. Homospecific activity of serum and tissue DBH. Life Sci. 1975; 17: 423
   Google Scholar
• Rockson S., Stone R., van der Weyder M., Kelley W. Lesch-Nyhan syndrome: evidence for abnormal adrenergic function. Science 1974; 186: 934
   PubMed Web of Science ®Google Scholar
• Roffman M., Freedman L. S., Goldstein M. The effect of acute and chronic swim stress. Life Sci. 1973; 12: 369
   Google Scholar
• Grzanna R., Coyle J. T. Absence of a relationship between sympathetic neuronal activity and turnover of serum DBH. Arch. Pharmacol. 1978; 304: 231
   Google Scholar
• Kuzuya H., Ikeno T., Ikeno K., Kato T., Nagatsu T. Dopamine β-hydroxylase activity in serum of developing rats. Experientia 1975; 32: 16
   Google Scholar
• Kato T., Ikuta K., Nagatsu Takahashi K. Changes in dopamine β-hydroxylase activity of monkey plasma with age. Experientia 1976; 32: 834
   Google Scholar
• Reid J. L., Kopin I. J. Significance of plasma dopamine β-hydroxylase activity as an index of sympathetic neuronal function. Proc. Nat. Acad. Sci. U.S.A. 1974; 71: 4392
   PubMed Web of Science ®Google Scholar
• Nagatsu T., Ikuta K., Numata Y., Kato T., Sano M. Vascular and brain dopamine β-hydroxylase activity in young spontaneously hypertensive rats. Science 1975; 191: 290
   Google Scholar
• Weinshilboum R., Axelrod J. Dopamine β-hydroxylase activity in the rat after hypophysectomy. Endocrinology 1970; 87: 894
   PubMed Web of Science ®Google Scholar
• Freedman L. S., Roffman M., Goldstein M., Fuxe K., Hokfelt T. Serum and tissue dopamine β-hydroxylase activity in hypophysectomized rats. Eur. J. Pharmacol. 1973; 24: 366
   Google Scholar
• Lamprecht F., Wooten G. F. Effect of hypophysectomy on serum dopamine-beta-hydroxylase activity in rat. Endocrinology 1973; 92: 1543
   Google Scholar
• Leon A. S., Thomas P. E., Sernatinger E., Canlas A. Preliminary evaluation of serum dopamine-beta-hydroxylase activity as an index of sympathetic activity in the rat and man. J. Clin. Pharmacol. 1974; 14: 354
   Google Scholar
• Weinshilboum R. M., Kvetnansky R., Axelrod J., Kopin I. J. Elevation of serum dopamine β-hydroxylase activity with forced immobilization. Nature (London) 1971; 230: 287
   Web of Science ®Google Scholar
• Lamprecht F., Williams R. B., Kopin I. J. Serum dopamine-beta-hydroxylase during development of immobilization-induced hypertension. Endocrinology 1973; 92: 953
   Google Scholar
• Ng L. K. Y., Lamprecht F., Williams R. B., Kopin I. J. Δ' Tetrahydrocannabinol and ethanol; differential effects on sympathetic activity in differing environmental setting. Science 1973; 180: 1368
   Google Scholar
• Kvetnansky R., Sun C. L., Lake C. R., Thoa N., Torda T., Kopin I. J. Effect of handling and forced immobilization on rat plasma levels of epinephrine, norepinephrine, and dopamine β-hydroxylase. Endocrinology 1978; 103: 1868
   PubMed Web of Science ®Google Scholar
• Nagatsu T., Kato T., Numato Y., Ikuta K., Umezawa H., Matsuzaki M., Takeuchi T. Serum dopamine β-hydroxylase activity in developing hypertensive rats. Nature (London) 1974; 251: 630
   PubMed Web of Science ®Google Scholar
• Anagnoste B., Freedman L. S., Goldstein M., Broome J., Fuxe K. Dopamine β-hydroxylase activity in mouse neuroblastoma tumors and in cell cultures. Proc. Nat. Acad. Sci. U.S.A. 1972; 69: 1883
   Google Scholar
• Ross S. B., Eriksson H. E., Hellstrom W. On the fate of dopamine β-hydroxylase after release from the peripheral sympathetic nerves in the cat. Acta Physiol. Scand. 1974; 92: 578
   Google Scholar
• de Potter W. P., de Potter R. W., de Smet F. H., Fraeyman N. N. DBH in the CSF and central noradrenergic activity: a pharmacological approach. Arch. Pharmacodyn. Ther. 1978; 232: 334
   Google Scholar
• Ross S. B., Wetterberg L., Myrhed M. Genetic control of plasma dopamine β-hydroxylase. Life Sci. 1973; 12: 529
   PubMedGoogle Scholar
• Weinshilbourn R. M., Raymond F. A., Elveback L. R., Weidman W. H. Dopamine β-hydroxylase activity in serum. Front. Catechol. Res. 1973; 1115
   Google Scholar
• Weinshilboum R. M., Dunnette J. H., Raymond F. A., Schrott H. G. Genetic control of human serum dopamine β-hydroxylase. Catecholamines and Stress, E. Usdin, R. Kvetnansky, I. J. Kopin. Pergamon Press, Oxford 1975
   Google Scholar
• Weinshilboum R. M., Raymond F. A., Elveback L. R., Weidman W. H. Serum dopamine β-hydroxylase activity: sibling-sibling correlation. Science 1973; 181: 943
   PubMedGoogle Scholar
• Steiner C, Geffen L. B., Levitt M., Frewin D., Craig R. J., Hewish D., Downey J. A., Luke W. K. Dopamine β-hydroxylase activity in plasma obtained from the pulmonary artery and left ventricle of man. Life Sci. 1974; 14: 2019
   Google Scholar
• Aberg H. E., Hansson H. E., Wetterberg L., Ross S. B., Froden O. Dopamine β-hydroxylase in human lymph. Life Sci. 1974; 14: 65
   PubMedGoogle Scholar
• Frewin D., Geffen L. B., Hewish D., Pilowsky I., Orange R., Wilson R. Diurnal variations in human serum dopamine β-hydroxylase activity. Proc. Aust. Physiol. Pharmacol. Soc. 1974
   Google Scholar
• Okada T., Fujita T., Ohta T. A 24 hour rhythm in human serum dopamine β-hydroxylase activity. Expcrientia 1974; 30: 605
   Google Scholar
• Fatranska M., Kvetnansky R., Jahnova E. Circadian rhythm of serum dopamine β-hydroxylase activity in healthy and blind men. Catecholamines and Stress, E. Usdin, R. Kvetnansky, I. J. Kopin. Pergamon Press, Oxford 1975
   Google Scholar
• Markianos E., Beckmann H. Diurnal changes in dopamine β-hydroxylase, homovanillic acid and 3-methoxyl-4-hydroxyphenylglycol in serum of man. J. Neural Trans. 1976; 39: 79
   PubMed Web of Science ®Google Scholar
• Vancauter E., Mendlewicz J. 24-hour DBH pattern — possible biological index of manic-depression. Life Sci. 1978; 22: 147
   Google Scholar
• Freedman L. S., Ohuchi T., Goldstein M., Axelrod F., Rish I., Dancis J. Changes in human serum dopamine β-hydroxylase activity with age. Nature (London) 1972; 236: 310
   PubMed Web of Science ®Google Scholar
• Stone R. A., Kirshner N., Gunnells J. C, Robinson R. R. Changes of plasma dopamine β-hydroxylase activity and other plasma constituents during the cold pressor test. Life Sci. 1974; 14: 1797
   PubMed Web of Science ®Google Scholar
• Planz G., Palm D. Acute enhancement of dopamine β-hydroxylase activity in human plasma after maximum work load. Europ. J. Clin. Pharmacol. 1973; 5: 255
   Google Scholar
• Planz G., Wiethold G., Appel E., Bolmer D., Palm D., Grobecker H. Correlation between increased dopamine β-hydroxylase activity and catecholamine concentration in plasma: determination of acute changes in sympathetic activity in man. Europ. J. Clin. Pharmacol. 1975; 8: 181
   PubMed Web of Science ®Google Scholar
• Ebstein R. P., Freedman L. S., Lieberman A., Park D. H., Pasternack B., Goldstein M., Coleman M. A familial study in serum dopamine β-hydroxylase levels in torsion dystonia. Neurology 1974; 24: 684
   Google Scholar
• Wooten G. F., Eldridge R., Axelrod J., Stern R. S. Elevated plasma dopamine β-hydroxylase activity in autosomal dominant torsion dystonia. N. Engl. J. Med. 1973; 284
   Google Scholar
• Weinshilboum R. M., Axelrod J. Reduced plasma DBH activity in familial dysautonomia. N. Engl. J. Med. 1971; 285: 938
   PubMed Web of Science ®Google Scholar
• Horwitz D., Alexander R. W., Lovenberg W., Keiser H. R. Human serum dopamine β-hydroxylase: relationship to hypertension and sympathetic activity. Circ. Res. 1973; 594
   Google Scholar
• Geffen L. B., Rush R. A., Louis W. J., Doyle A. E. Plasma catecholamine and dopamine β-hydroxylase amounts in phaeochromocytoma. Clin. Sci. 1973; 44: 421
   Google Scholar
• Helle K. B. Circulating DBH and catecholamines in a paediatric phaeochromocytoma. Clin. Exp. Pharmacol. Physiol. 1976; 3: 487
   Google Scholar
• Aunis D., Bouclier M. Comparative study of plasma dopamine β-hydroxylase activities in noradrenaline-secreting and adrenaline-secreting phaeochromocytomal. Clin. Exp. Pharmacol. Physiol. 1977; 4
   Google Scholar
• Kopin I. J. DBH — Basic and clinical studies. Annu. Int. Med. 1976; 85: 211
   PubMed Web of Science ®Google Scholar
• Naftchi N. E., Wooten G. F., Lowman E. W., Axelrod J. Relationship between serum dopamine β-hydroxylase activity, catecholamine metabolism and hemodynamic changes during paroxysmal hypertension in quadriplegia. Circ. Res. 1974; 35: 850
   PubMed Web of Science ®Google Scholar
• Levitt M., Frewin D. B., Co C. C, Luke W. K., Downey J. A. Plasma dopamine-hydroxylase activity in paraplegic and quadriplegic subjects. Aust. N. A. J. Med. 1974; 4: 48
   Google Scholar
• Fujita K., Ito T., Maruta K., Teradaira R., Beppu H., Nakagami Y., Kato Y. Serum dopamine β-hydroxylase in schizophrenic patients. J. Neurochem. 1978; 30: 1569
   PubMed Web of Science ®Google Scholar
• Okada T., Ohu T., Shinoda T., Kato T., Ikuta K., Nagatsu T. Dopamine β-hydroxylase activity in serum and cerebrospinal fluid in neuropsychiatry diseases. Neuropsychobiology 1976; 2: 139
   Google Scholar
• Goldstein D. J., Cubeddu L. W. Dopamine β-hydroxylase activity in human cerebrospinal fluid. J. Neurochem. 1976; 26: 193
   Google Scholar
• Wyatt R. J., Schwartz M. A., Erdelyi E., Barchas J. D. Dopamine β-hydroxylase activity in brains of chronic schizophrenic patients. Science 1975; 368
   Google Scholar
• Wise C. D., Stein L. Dopamine β-hydroxylase deficits in the brains of schizophrenic patients. Science 1973; 181: 344
   PubMed Web of Science ®Google Scholar
• Silbergeld S., Kvetnansky R., Sigalos G. L., Weise V. K., Kopin I. J. Levels of adrenal catecholamine-synthesizing enzymes after postmortem treatment in rats and after necropsy in human beings. J. Clin. Med. 1971; 77
   Google Scholar
• Black I. B., Green S. C. Postmortem changes in brain catecholamine enzymes. Arch. Neurol. 1975; 32: 47
   Google Scholar
• Wyatt R. J., Erdelyi E., Schwartz M., Herman M., Barchas J. D. Difficulties in comparing catecholamine-related enzymes from the brains of schizophrenics and controls. Biol. Psychiatry 1977; 13: 317
   Google Scholar
• Rosenblatt S., Leighton W. P., Chanley J. D. Dopamine β-hydroxylase: evidence for increased activity in sympathetic neurons during psychotic states. Science 1975; 182: 923
   Google Scholar
• Shopsin B., Freedman L. S., Goldstein M., Gershon S. Serum DBH activity and affective states. Psychopharmacologia 1972; 21: 11
   Google Scholar
• Wetterberg L., Aberg H., Ross S. B., Froden O. Plasma DBH activity in hypertension and various neuropsychiatric disorders. Scand. J. Clin. Lab. Invest. 1972; 30: 283
   PubMed Web of Science ®Google Scholar
• Friedman M. J., Sfolk J. M. Depression, Hypertension and serum dopamine β-hydroxylase activity. Psychosom. Med. 1978; 40: 107
   Google Scholar
• Lerner P., Goodwin F. K., van Kammen D. P., Post R. M., Major L. F., Ballenger J. C, Lovenberg W. Dopamine β-hydroxylase in the cerebrospinal fluid of psychiatric patients. Biol. Psychiatry 1978; 13: 685
   Google Scholar
• Christensen N. J. Increased levels of plasma noradrenaline in hypothyroidism. J. Clin. Endocrinol. Metab. 1972; 35: 359
   PubMed Web of Science ®Google Scholar
• Nishizawa Y., Hamada N., Fujii S. Serum dopamine β-hydroxylase activity in thyroid disorders. J. Clin. Endocrinol. Metab. 1974; 39: 599
   Google Scholar
• Berkowitz B. A., Head R. J. Adrenal origin of plasma catecholamines after decapitation: a study in normal and diabetic rats. Br. J. Pharmacol. 1978; 64: 3
   Google Scholar
• Bennett T., Kemp P. A., Wilson M. F. Serum DBH activity exercise-induced in human subjects. J. Physiol. 1974; 238: 57
   Google Scholar
• Frewin D. B., Downey J. A., Levitt M. The effect of heat, cold and exercise in plasma dopamine β-hydroxylase activity in man. Can. J. Physiol. Pharmacol. 1973; 51: 986
   Google Scholar
• Freedman L. S., Ebstein R. P., Park D. H., Levitz S. M., Goldstein M. The effect of cold pressor test in man on serum immunoreactive dopamine β-hydroxylase and on dopamine β-hydroxylase activity. Res. Commun. Chem. Pathol. Pharmacol. 1973; 6: 873
   Google Scholar
• Takishita S., Fukiyama K., Kumamoto K., Noda Y., Kawasaki T., Omae T. Plasma dopamine β-hydroxylase activity in normal young men: its responsiveness to manipulation of sodium balance and upright posture. Jpn. Circ. J. 1977; 41: 895
   PubMedGoogle Scholar
• Hashimoto Y., Kurobe Y., Kirota K. Effect of delivery on serum DBH activity and urinary vanillyl mandelic acid excretion of normal pregnant subjects. Biochem. Pharmacol. 1974; 23: 2185
   Google Scholar
• Langos J., Kvetnansky R., Blazicek P., Novotny J., Vencei P., Burdiga A., Mikulaj L. Plasma renin and dopamine β-hydroxylase activity and catecholamine excretion in man during stress. Catecholamine and Stress, E. Usdin, R. Kvetnansky, I. J. Kopin. Pergamon Press, Oxford 1975
   Google Scholar
• Goldstein M., Freedman L. S., Ebstein R. P., Park D. H. Studies on DBH in mental disorders. J. Psychiatr. Res. 1974; 11: 205
   Google Scholar
• Lamprecht F., Ebert M. H., Turek I., Kopin J. Serum DBH in depressed patients and the effect of electroconvulsive shock treatment. Psychopharmacologia 1974; 40: 241
   Google Scholar
• Gustavson K. H., Ross S. B., Sanner G. Low serum dopamine β-hydroxylase activity in the dysequilibrium syndrome. Clin. Gen. 1977; 11: 270
   Google Scholar
• Wetterberg L., Gustavson K. H., Backstrom M., Ross S. B., Froden O. Low DBH activity in Down's syndrome. Clin. Genet. 1972; 3: 152
   PubMed Web of Science ®Google Scholar
• Freedman L. S., Goldstein M. Serum dopamine β-hydroxylase activity in Down's syndrome: a familial study. Res. Commun. Chem. Pathol. Pharmacol. 1974; 8: 543
   Google Scholar
• Freedman L. S., Roffman M., Goldstein M. Changes in human serum dopamine β-hydroxylase activity in various physiological and pathological states. Front. Catechol. Res. 1973; 1109
   Google Scholar
• Planz G., Yilmaz E., Palm D. Plasma dopamine β-hydroxylase activity as a measure of sympathetic activity during halothane anaesthesia in children. Eur. J. Clin. Pharmacol. 1973; 6: 228
   Google Scholar
• Mattsson B., Wetterberg L., Ross S. B. Plasma dopamine-beta-hydroxylase in Huntington's chorea. Acta Psychiatr. Scand. 1974; 255: 237
   Google Scholar
• Rapoport J. L., Quinn P. O., Lamprecht F. Minor physical anomalies and plasma DBH activity in hyper active boys. Am. J. Psychiatry 1974; 131: 386
   PubMed Web of Science ®Google Scholar
• Aberg H., Wetterberg L., Ross S.B., Froden O. Dopamine β-hydroxylase in hypertension. Acta Med. Scand. 1974; 196: 17
   PubMedGoogle Scholar
• Aberg H., Hedstrand H., Wetterberg L., Ross S. Dopamine β-hydroxylase and plasma renin activity in twenty hypertensive subjects. Upsala J. Med. Sci. 1975; 80: 24
   PubMed Web of Science ®Google Scholar
• Aberg H., Hedstrand H., Wetterberg L., Ross S. Dopamine β-hydroxylase after treatment with β-blockers in hypertension. Int. J. Clin. Pharmacol. 1975; 11: 15
   Google Scholar
• Rockson B. G., Stone R. A., Gunnells J. C. Plasma DBH activity in oral contraceptive hypertension. Circulation 1975; 51: 916
   PubMed Web of Science ®Google Scholar
• Geffen L. B., Rush R. A., Louis W. J., Doyle A. E. Plasma DBH and noradrenergic amounts in essential hypertension. Clin. Sci. 1973; 44: 617
   PubMed Web of Science ®Google Scholar
• Balazovjech I., Kvetnansky R., Harsanyi M., Mikulaj L. Effect of work load on plasma dopamine β-hydroxylase activity and Cortisol in patients with essential hypertension. Catecholamines and Stress, E. Usdin, R. Kvetnansky, I. J. Kopin. Pergamon Press, Oxford 1975
   Google Scholar
• Stone R. A., Gunnells J. C., Robinson R. R., Schanberg S. M., Kirshner N. Dopamine-beta-hydroxylase in primary and secondary hypertension. Circ. Res. 1974; 34
   Google Scholar
• Lake C. R., Ziegler M. G., Coleman M., Kopin I. J. Lack of correlation of plasma norepinephrine and DBH in hypertensive and normotensive subjects. Circ. Res. 1977; 41: 865
   PubMedGoogle Scholar
• Naftchi N. E., Demeny M., Lowman E. W., Tuckman J. Effect of hypertensive stress on plasma dopamine β-hydroxylase activity and prostaglandins in quadriplegia. Catecholamines and Stress, E. Usdin, R. Kvetnansky, I. J. Kopin. Pergamon Press, Oxford 1975
   Google Scholar
• Frankel H. L., Mathias C. J., Smith A. D., Spalding J. M. K. Release of DBH during sympathetic nervous activity in tetraplegic man. J. Physiol. 1975; 247: 38
   Google Scholar
• Lake C. R., Ziegler M. G. Effect of acute volume alterations on norepinephrine and DBH in normotensive and hypertensive subjects. Circulation 1978; 57: 774
   PubMed Web of Science ®Google Scholar
• Oberman Z., Herzeberg M. Decrease in serum DBH activity during oral glucose tolerance test. Isr. J. Med. Sci. 1978; 14: 798
   Google Scholar
• Nisula B. C., Stolk J. M. Serum DBH activity does not reflect sympathetic activation during hypoglycaemia. J. Clin. Endocrinol. Metab. 1978; 49: 902
   Google Scholar
• Okada F., Yamashita I., Suwa N., Kunita H., Hata S. Elevation of plasma dopamine β-hydroxylase activity during insulin-induced hypoglycemia in man. Experientia 1975; 37: 70
   Google Scholar
• Rockson S., Stone R., van der Weyden M., Kelley W. N. Lesch-Nyhan syndrome: evidence for abnormal adrenergic function. Science 1974; 186: 934
   PubMed Web of Science ®Google Scholar
• Gutteberg T., Borud O., Strome J. H. Dopamine β-hydroxylase activity in serum following acute myocardial infarction: an evaluation of this parameter for routine use as an index of sympathetic activity. Clin. Chim. Acta 1976; 69: 61
   Google Scholar
• Goldstein M., Freedman L. S., Bohuon A. C, Guerinot F. Serum dopamine β-hydroxylase activity in neuroblastoma. N. Engl. J. Med. 1972; 286: 1123
   Google Scholar
• Markianos E. S., Ruther E. Serum DBH in parkinsonism. J. Neural Transm. 1977; 40: 21
   Google Scholar
• Lamprecht F., Wyatt R. J., Blemaker R., Murphy D. L., Pollin W. Plasma dopamine-beta-hydroxylase in identical twins discordant for schizophrenia. Front. Catechol. Res. 1973; 1123
   Google Scholar
• Dunner D. L., Cohn C. K., Weinshilboum R. M., Wyatt R. J. The activity of DBH and methionine-activating enzyme in blood of schizophrenic patients. Biol. Psychiatry 1973; 6: 215
   Google Scholar
• Brown F., Coleman J. H. Dopamine-beta-hydroxylase in nerve function and mental illness. Dis. Nerv. Syst. 1975; 36: 383
   Google Scholar
• Benedict C. R., Grahame-Smith D. G. Plasma noradrenaline and adrenaline concentrations and DBH activity in patients with shock due to septicaemia, trauma and haemorrhage. Q. J. Med. 1978; 47: 1
   PubMedGoogle Scholar
• Harden T. K., Klein R. L., Smith R. R., Thurseson A. K., Lowry M. W. Serum dopamine β-hydroxylase activity following subarachnoid hemorrhage in man. Med. Biol. 1975; 53: 100
   Google Scholar
• Annat G., Raudrant D., Chappe J., Vincent M., Tboulon J., Dumont M., Sassard J. Maternal and fetal plasma renin and DBH activities in toxemic pregnancy. Obstet. Gynecol. 1978; 52: 219
   PubMed Web of Science ®Google Scholar
• Lieberman A. N., Freedman L. S., Goldstein M. Serum Dopamine β-hydroxylase activity in patients with Huntington's chorea and Parkinson's disease. Lancet 1972; 153–154
   Google Scholar