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Original Article

Interferon—Present and Future Prospects

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Pages 57-93 | Published online: 02 Jul 2009

References

  • Adolf G. R., Swetly P. Interferon production in human hematopoietic cell lines: response to chemicals and characterization of interferons. J. Interferon Res. 1982; 2: 261
  • Anand S. C., Itkin I. H., Kind L. S. Effect of influenza vaccine on methacholine sensitivity in patients with asthma of known and unknown origin. J. Allergy 1968; 42: 187
  • Atherton K. T., Burke D. C. The effects of some different metabolic inhibitors on interferon superinduction. J. Gen. Virol. 1978; 41: 229
  • Baglionl C., Minks M. A., Maroney P. A. Interferon action may be mediated by activation of a nuclease by pppA2iˇ p5iˇ, A2iˇ p5iˇ A. Nature (London) 1978; 273: 684
  • Balkwill F., Taylor-Papadimitriou J. Interferon affects both G1 and S + G2 in cells stimulated from quiescence to growth. Nature (London) 1978; 274: 798
  • Ball L. A. Induction of 2iˇ5iˇ-oligoadenylate synthetase activity and a new protein by chick interferon. Virology 1979; 94: 282
  • Ball L. A., White C. N. Nuclease activation by double-stranded RNA and by 2iˇ,5iˇ-oligoadenylate in extracts of interferon-treated chick cells. Virology 1969; 93: 348
  • Basham T. Y., Bourgeade M. F., Creasey A. A., Merigan T. C. Interferon increases HLA synthesis in melanoma cells: Interferon-resistant and -sensitive cell lines. Proc. Natl. Acad. Sci. 1982; 79: 3265
  • Beck J., Brunner H., Marchuchi F., Cuschner H., Wisenbern J. Induction of IFN by micoplasmas and mouse spleen cell cultures. J. IFN Res. 1982; 2: 1
  • Berkovich S., Milliam S. J., Snyder R. D. The association of viral and mycoplasma infections with recurrence of wheezing in the asthmatic child. Ann. Allergy 1970; 28: 43
  • Billiau A., DeSomer P., Edy V. G., DeClercq E., Heremans H. Human fibroblast interferon for clinical trials: pharmacokinetics and tolerability in experimental animals and humans. Antimicrob. Agents Chemother. 1979; 16(1)56
  • Bino T., Madar Z., Gertler A., Rosenberg H. The kidney is the main site of interferon degradation. J. Interferon Res. 1982; 2(2)301
  • Blalock J. E., Georgiades J. A., Langford M. P., Johnson H. M. Purified human immune interferon has more potent anti-cellular activity than fibroblast or leukocyte interferon. Cell. Immunol. 1980; 49: 390
  • Blalock J. E., Smith E. M. Human leukocyte interferon (HuIFN-α): potent endorphin-like opioid activity. Biochem. Biophys. Res. Commun. 1981; 101(2)472
  • Blalock J. E., Stanton J. D. Common pathways of interferon and hormonal action. Nature (London) 1980; 283: 406
  • Bloom B. R. Interferons and the immune system. Nature (London) 1980; 284: 593
  • Bocci V. Production and role of interferon in physiological conditions. Biol. Rev. 1981; 56: 49
  • Borden E. C. Perspective. Interferons: rationale for clinical trials in neoplastic disease. Ann. Int. Med. 1979; 91: 472
  • Borden E. C., Hawkins J. J. Interferons for human neoplastic and viral diseases. Comprehensive Ther. 1980; 6: 6
  • Bordon E. C., Holland J. F., Dao T. L., Gutterman J. U., Wiener L., Chang Y., Patel J. Leukocyte derived IFN (alpha) in human breast carcinoma, human cancer society Phase II trial. Ann. Int. Med. 1982; 97: 1
  • Borgstrom S., Edler von Eyben F., Flodgren P., Axelsson B., Sjogren H. O. Human leukocyte interferon and cimetidine for metastatic melanoma. N. Engl. J. Med. 1982; 307: 1080
  • Bradley E. C., Ruscetti F. W. Effect of fibroblast, lymphoid and myeloid interferons on human tumor colony formation in vitro. Cancer Res. 1981; 41: 244
  • Breinig M. C., Ho M., White L., Armstrong J. A., Pazin G. J., Haverkos H. W., Cantell K. Effect of prolonged administration of interferon-alpha on pharmacokinetics, fever, lymphocyte proliferation response, and NI cell activity. J. Interferon Res. 1982; 2(2)195
  • Burke D. C., Graham C. F., Lehman J. M. Appearance of interferon inducibility and sensitivity during differentiation of murine teratocarcinoma cells in vitro. Cell 1978; 13: 243
  • Calvet M. C., Gresser P. Interferon enhances the excitability of cultural neurones. Nature (London) 1979; 278: 5585
  • Cantell K., Hirvonen S. Large scale production of human leukocyte interferon containing 108 units/mℓ. J. Gen. Virol. 1978; 39: 541
  • Cantell K., Hirvonen S. Preparation of human leukocyte interferon for clinical use. The interferon system: a current review to 1978. Tex. Rep. Biol. Med. 1977; 35: 138
  • Cantell K., Pyhala L. Pharmacokinetics of human interferons. J. Infect. Dis. 1976, A.: 6
  • Cantell K., Strander H., Saxen L., Meyer B. Interferon response of human leukocytes during intrauterine and postnatal life. J. Immunol. 1968; 100: 1304
  • Cerottini J. C., Brunner K. T., Lindahl P., Gresser I. Inhibitory effect of interferon preparations and inducers on the multiplication of transplanted allogenetic spleen cells and syngenic bone marrow cells. Nature New Biol. 1973; 242: 152
  • Chany C., Duc-Goiran P., Chudzio T., Lebon P., Robert-Galliot B. Presence of interferons in human amniotic fluid (Abstr. 023). J. Cell. Biochem. 1982; 6: 83, (Suppl.)
  • Chany C., Gregoire A., Vignal M., Lemaitre-Moncutt J., Brown P., Besancon F., Suarez H., Cassingena R. Mechanism of interferon uptake in parental and somatic monkey-mouse hybrid cells. Proc. Natl. Acad. Sci. 1973; 70: 557
  • Chany C., Rousset S., Bourgeade M. F., Mathieu D., Gregoire A. Role of receptors and the cytoskeleton in reverse transformation and steroidogenesis induced by interferon. Ann. N.Y. Acad Sci. 1980; 350: 254
  • Cheeseman S. H., Rubin R. H., Stewart J. A., Tolkoff-Rubin N. E., Cosimi A. B., Cantell K., Gilbert J., Winkel S., Herrin J. T., Black P. H., Russell P. S., Hirsch M. S. Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation. Effects of cytomegalovirus and herpes simplex virus infections. N. Engl. J. Med. 1979; 300: 1345
  • Chirigos M. A., Schultz R. M., Stylos W. A. Interaction of interferon, macrophage and lymphocyte tumoricidal activity with prostaglandin effect. Ann. N.Y. Acad. Sci. 1980; 350: 91
  • Chisholm M., Cartwright T. Interferon production in leukemia. Br. J. Hematol. 1978; 40: 43
  • Cioe L., O'Brien T. G., Diamond L. Inhibition of adipose conversion of BALB/c3T3 cells by interferon and 12–0-tetradecanoyl pharbol-13-acetate. Cell. Biol. Int. Rep. 1980; 4: 255
  • Clemens M. J., Williams B. R. G. Inhibition of cell-free protein synthesis by ppA2iˇp5iˇA2iˇp5iˇA: A novel oligonucleotide synthesized by interferontreated L-cell extracts. Cell 1978; 13: 565
  • Content J., DeWitt L., Pierard D., Derynck R., DeClercq E., Fiers W. Secretory proteins induced in human fibroblasts under conditions used for the production of interferon B. Proc. Natl. Acad. Sci. 1982; 79: 2768
  • Creasey C. A., Bartholomew J. C., Merigan T. C. Role of G0-G1 arrest in the inhibition of tumor cell growth by interferon. Proc. Natl. Acad. Sci. U.S.A. 1980; 77: 1471
  • Cuatrecasas P. Interaction of insulin with the cell membrane: the primary action of insulin. Proc. Natl. Acad. Sci. U.S.A. 1969; 63: 450
  • Czarniecki C. W., Streevalsan T., Friedman R. M., Panet A. Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells. J. Virol. 1981; 37: 827
  • Dawson A. A., Forman D. M., Entrican J. H. Appendectomy and tonsillectomy in patients with lymphomas. Clin. Oncol. 1979; 5: 221
  • DeHaro C., Ochoa S. Mode of action of the hemin-controlled inhibitor of protein synthesis: studies with factors from rabbit reticulocyte lysates. Proc. Natl. Acad. Sci. 1978; 75: 2713
  • DeKoning E. W. J., Van Bijsterveld O. P., Cantell K. Combination therapy for dendritic keratitis with human leucocyte interferon and trifluorothymidine. Br. J. Ophthalmol. 1982; 66: 509
  • Dianzani F., Baron S. Unexpectedly rapid action of human interferon in physiological conditions. Nature (London) 1975; 257: 682
  • Dianzani F., Levy H. B., Berg S., Baron S. Kinetics of the rapid action of interferon (39447). Proc. Soc. Exp. Biol. Med. 1976; 152: 593
  • Dianzani F., Monahan T. M., Santiamo M. Membrane alteration responsible for the induction of gamma interferon. Infect. Immunity 1982; 36(3)915
  • Dianzani F., Monahan T. M., Scupham A., Zucca M. Enzymatic induction of interferon production by galactose oxidase treatment of human lymphoid cells. Infect. Immunity 1979; 26: 879
  • Distafano, et al. Lupus-like IFN and immuno-deficiency syndrome. J. Infect. Dis. 1982; 146: 451
  • Donahoe R. M., Huang K. Y. Interferon preparations enhance phagocytosis in vivo. Infect. Immunol. 1976; 13: 1250
  • Dunnick J. K., Glasso G. J. Clinical trials of exogenous interferon: summary of a meeting. J. Infect. Dis. 1979; 139: 109
  • Einhorn S., Ahre A., Blomgren H., Johansson B., Mellstedt H., Strander H. Interferon and natural killer activity in multiple myeloma. Lack of correlation between interferon-induced enhancement of natural killer activity and clinical response to human interferon-α. Int. J. Cancer 1982; 30: 167
  • Eisen A. H. The role of infection in allergic disease. Pediatr. Clin. N. Am. 1969; 16: 67
  • Emodi G., Just M. Impaired interferon response of children with congenital cytomegalic virus disease. Acta Paediat. Scand. 1974; 63: 183
  • Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanism of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am. Rev. Respir. Dis. 1976; 113: 131
  • Eppstein D. A., Peterson T. C., Samuel C. E. Mechanism of interferon action: Synthesis and activity of the interferon-mediated low-molecular-weight oligonucleotide from murine and human cells. Virology 1979; 98: 9
  • Epstein L. B., Cline M. J. Chronic lymphocytic leukemia: studies on mitogen stimulated lymphocyte interferon as a new technique for assessing T lymphocyte effector function. Clin. Exp. Immunol. 1974; 16: 553
  • Epstein L. B. Interferon-gamma: success, structure and speculation. Nature (London) 1982; 295: 453
  • Epstein L. B., Lee S. H. S., Epstein C. J. Enhanced sensitivity of trisomy 21 monocytes to the maturation-inhibiting effect of interferon. Cell. Immunol. 1980; 50: 191
  • Epstein L. B., Rose M. E., McManus N. H., Li C. H. Absence of functional and structural hemology of natural and recombinate human leukocyte interferon (IFN-alpha) with human alpha-ACTH and beta-endorphin. Biochem. Biophys. Res. Commun. 1982; 104: 341
  • Epstein L. B., Shen J. T., Abele J. S., Reese C. C. Sensitivity of human ovarian carcinoma cells to interferon and other antitumor agents as assessed by an in vitro semi-solid agar technique. Ann. N.Y. Acad. Sci. 1980; 350: 228
  • Ernestoff M. S., Davis C. A., Ferraresi R. W., Rudnick S., Kirkwood J. M. Toxicity and antitumor effects of daily recombinant human IFN-α. 1982, Abstract Eastern Section AFCR
  • Evinger M., Rubinstein M., Peska S. Growth-inhibitory and anti-viral activity of purified leukocyte interferon. Ann. N.Y. Acad. Sci. 1980; 350: 399
  • Falcoff E., Falcoff R., Lebleu B., Revel M. Correlation between the antiviral effect of interferon treatment and the inhibition of in vitro mRNA translation in noninfected L cells. J. Virol. 1973; 12: 421
  • Falcoff R., Sanceau J. Mengovirus-induced inhibition of cell protein synthesis and subsequent recovery of cellular activity in interferon pretreated cells. Virology 1979; 98: 433
  • Fauconnier B. Large scale production of human interferon from human spleens. J. Interferon Res. 1980; 1: 1517
  • Field A., Tytell A., Lampson G., Hilleman M. Inducers of interferon in host resistance. II. Multistranded synthetic polynucleotide complexes. Proc. Natl. Acad. Sci. 1967; 58: 1004
  • Floyd-Smith G., Slattery E., Lengyel P. Interferon action: RNA cleavage pattern of a (2iˇ-5iˇ) oligoadenylate-dependent endonuclease. Science 1981; 212: 1030
  • Friedman R. M. Antiviral activity of interferon. Bacterial Rev. 1977; 41: 543
  • Friedman R. M. Cell surface alterations induced by interferon methods. Enzymology 1981; 79: 458
  • Friedman R. M. Interferon binding: the first step in establishment of antiviral activity. Science 1967; 156: 1760
  • Friedman R. M., Chang E. H. Interferon Action: Possible Mechanisms of Antiviral Activity, W. E. Stewart, II. CRC Press, Boca Raton, Fla 1977; 145
  • Friedman R. M. Inhibition of arborvirus protein synthesis by interferon. J. Virol. 1968; 2: 1081
  • Friedman R. M., Metz D. H., Esteban R. M., Tovell D. R., Ball L. A., Kerr I. M. Mechanism of interferon action inhibition of viral messenger ribonucleic acid translation in L-cell extracts. J. Virol. 1972; 10: 1184
  • Friedman R. M., Pastan I. Interferon and cyclic-3iˇ-5iˇ-adenosine monophosphate: potentiation of antiviral activity. Biochem. Biophys. Res. Commun. 1969; 36: 735
  • Friedman R. M., Sonnabend J. A. Inhibition of interferon action by puromycin. J. Immunol. 1965; 95(4)696
  • Gadzik J. P., Alinaji, Barker C. F., Blank K. J. Inhibition of virus-induced murine diabetes by an interferon inducer. J. Interferon Res. 1982; 2: 59
  • Gewert D. R., Clemens M. J. Inhibition of interferon of thymidine uptake and deoxyribonucleic acid synthesis in human lymphoblastoid cells. Biochem. Soc. Trans. 1980; 8: 353
  • Gewert D. R., Shah S., Clemens M. J. Inhibition of cell division by interferons: changes in the transport and intracellular metabolism of thymidine in human lymphoblastoid (Daudi) cells. Eur. J. Biochem. 1981; 116: 487
  • Gifford G. E., Koch A. L. The interferon dose response curve and its possible significance. J. Theor. Biol. 1969; 22: 271
  • Gobel U., Arnold W., Wahn V., Treuner J., Jurgens H., Cantell K. Comparison of human fibroblast and leukocyte interferon in the treatment of severe laryngeal papillomatosis in children. Eur. J. Pediatr. 1981; 137: 175
  • Gober L. L., Friedman-Kien A. E., Havell E. A., Vilcek J. Suppression of the intracellular growth of Shigella flexneri in cell cultures by interferon preparations and polyinosinic-polycytidylic acid. Infect. Immunol. 1972; 5: 370
  • Goepfert H., Gutterman J. U., Dichtel W. J., Sessions R. B., Cangir A., Sulek M. Leukocyte interferon in patients with juvenile laryngeal papillomatosis. Ann. Otol. Rhinol. Laryngol. 1982; 91: 431
  • Goodwin J. S., Webb D. R. Review: Regulation of the immune response by prostaglandins. Clin. Immunol. Immunopathol. 1980; 15: 106
  • Gordon J., Minks M. A. The interferon renaissance: molecular aspects of induction and action. Microbiol. Rev. 1981; 45(2)244
  • Gray P. W., Goeddel D. V. Structure of the human immune interferon gene. Nature (London) 1982; 298: 859
  • Green J. A. Inhibition of Shigella flexneri by lysates of cells treated with interferon-containing preparations. Infect. Immunol. 1973; 7(6)1006
  • Greenberg H. B., Pollard R. B., Lutwich L. I., Gregorn P. O., Robinson W. S., Merrigan T. C. Effect of human leukocyte interferon on hepatis B virus infection in patients with chronic active hepatitis. N. Engl. J. Med. 1976; 295: 517
  • Greeser I., Bandu M., Brouty-Boye D., Tovey M. Pronounced antiviral activity of human interferon on bovine and porcine cells. Nature (London) 1974; 251: 543
  • Greeser I., Morel-Morager L., Riviere Y., Guillon J., Tovey M., Woodrow D., Sloper J., Moss J. Interferon induced disease in mice and rats. Ann. N.Y. Acad. Sci. 1980; 350: 12
  • Gresser I., Tovey M. G., Maury C., Couroulinkoy I. Lethality of interferon preparations for newborn mice. Nature (London) 1975; 285: 76
  • Gresser I., Morel-Maroger L., Chatelet F., Maury C., Tovey M., Bandu M.-T., Buywid J., Delauche M. Delays in growth and the development of nephritis in rats treated with interferon preparations in the neonatal period. Am. J. Pathol. 1979; 95: 329
  • Grossbery S. E. The interferons and their inducers: molecular and therapeutic considerations. N. Engl. J. Med. 1972; 287: 13, 287, 79, 1972; 287, 122, 1972.
  • Grossberg S. E., Morahan P. S. Repression on interferon action: induced differentiation of embryonic cells. Science 1971; 171: 77
  • Gupta S. L., Sopori M. L., Lengyel P. Inhibition of protein synthesis directed by added viral and cellular messenger RNAs in extracts of interferon-treated Ehrlich ascites tumor cells. Location and dominance of the inhibitor(s). Biochem. Biophys. Res. Commun. 1973; 54: 777
  • Gutterman J. U., Fine S., Quesada J., Horning S. J., Levine J. F., Alexanian R., Colburn W., Trown P., Merigan T., Dziewanowski Z. Recombinant leukocyte A interferon: Parmacokinetics, single-dose tolerance, and biological effects in cancer patients. Ann. Int. Med. 1982; 96: 549
  • Gutterman J. U., Blumenschien G. R., Alexanian R., Yap H., Buzdar A. U., Cabanillas F., Hortobagyi G. N., Hersh E. M., Rasmussen S. L., Harmon M., Kramer M., Pestka S. Leukocyte interferon-induced tumor regression in hyman metastatic breast cancer, multiple myeloma, and malignant lymphoma. Ann. Int. Med. 1980; 93: 399
  • Haglund S., Lundquist Perk, Cantell K., Strander H. Interferon therapy in juvenile laryngeal papillomatosis. Arch. Otolaryngol. 1981; 107: 327
  • Hahn T., Levine S., Handzel Z. T. Production of immune and viral interferon by lymphocytes of newborn infants. Isr. J. Med. Sci. 1980; 16: 33
  • Hahn T., Levine S. The interferon system in patients with malignant disease. J. INF Res. 1982; 2: 97
  • Handa K., Suzuki R., Matsui H., Shimizu Y., Kumagai K. Natural killer (NK) cells as a responder to interleukin 2 (IL 2). J. Immunol. 1983; 130: 988
  • Harfast B., Huddlestone J. R., Casali P., Merigan T. C., Oldstone M. B. A. Interferon acts directly on human B lymphocytes to modulate immunoglobulin synthesis. J. Immunol. 1981; 127(5)2146
  • Harmon M. W., Greenberg S. B., Couch R. B. Effect of human nasal secretions on the antiviral activity of human fibroblast and leukocyte interferon (39448). Proc. Soc. Exp. Biol. Med. 1976; 152: 598
  • Harned C. L., Nerland D. E., Sonnenfeld G. Effects of passive transfer induction of gamma (Type II immune) interferon preparations on the metabolism of diphenylhydantoin by murine cytochrome P-450. J. Interferon Res. 1982; 2: 5
  • Havell E. A., Vilcek J. Production of high-titered interferon in cultures of human diploid cells. Antimicrob. Agents Chemother. 1972; 2: 476
  • Heine J. W., Adler W. H. The quantitative production of interferon by mitogen-stimulated mouse lymphocytes as a function of age and its effect on the lymphocytes proliferative response. J. Immunol. 1977; 118: 1366
  • Herberman R. B., Ortaldo J. R., Djeu J. Y., Holden T., Jett J., Lang N. O., Rubinstein M., Pestka S. Role of interferon in regulation of cytotoxicity by natural killer cells and macrophages. Ann. N.Y. Acad. Sci. 1980; 350: 63
  • Herberman R. B., Ortaldo J. R. Natural killer cells: their role in defenses against disease. Science 1981; 214: 24
  • Hilfenhaus J., Mauler R. Human fibroblast and human leukocyte interferon: their differences in cell growth and inhibition activities on lymphoblastoid cells. Ann. N.Y. Acad. Sci. 1980; 350: 626
  • Hill N. O., Pardue A., Khan A., Hill R. W., Aleman C., Hilario, Hill J. M., Osther K. Interferon and cimetidine for malignant melanoma. N. Engl. J. Med. 1983; 308: 286
  • Ho M. Interferon-light viral inhibitor in rabbits after intravenous administration of enterotoxin. Science 1964; 146: 14
  • Ho M. Patterns of interferon appearances in mice injected with bacteria or bacterial endotoxin. Nature (London) 1964; 204: 1712
  • Ho M., Armstrong J. A. Interferon. Ann. Rev. Microbiol. 1975; 29: 131
  • Honigsberger L., Fielding J. W., Prestman T. J. Neurological effects of recombinant human interferon. Br. Ned. J. 1983; 286: 719
  • Hooks J. J., Moutsopoulos H. M., Notkins A. L. The role of interferon in immediate hypersensitivity and autoimmune diseases. Ann. N.Y. Acad. Sci. 1980; 350: 21
  • Hooks J. J., Moutsopoulus H. N., Geis S. A., Stahl N. I. L., Notkins A. L. Immune interferon in the circulation of patients with autoimmune disease. N. Engl. J. Med. 1979; 301: 5
  • Hovanessian A. G., Brown R. E., Kerr I. M. Synthesis of low modular weight inhibitor of protein synthesis with enzyme from interferon treated cells. Nature (London) 1979; 268: 537
  • Huang K. Y., Donahoe R. M., Gordon F. B., Dressier H. R. Enhancement of phagocytosis by interferon-containing preparations. Infect. Immunol. 1976; 4: 581
  • Huhti E. T., Mokka T., Nikoskelainen J., Halonen P. Association of viral and mycoplasma infections with exacerbations of asthma. Ann. Allergy 1974; 33: 145
  • Ida S., Hooks J. J., Siraganian R. P., Notkins A. L. Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J. Exp. Med. 1977; 145: 892
  • Imanishi J., Karaki T., Sasaki O., Matsuo A., Oishi K., Pak C., Kishida T., Toda S., Nagata H. The preventive effect of human interferon-alpha preparation on upper respiratory disease. J. Interferon Res. 1980; 1(1)169
  • Ingimarsson S., Cantell K., Carlstrom G., et al. Immune reactions and long-term therapy with human leukocyte interferon. Acta. Med. Scand. 1981; 209: 17
  • Ingrimarsson S., Cantell K., Strander H. Side effects of long-term treatment with human leukocyte interferon. J. Infect. Dis. 1979; 140: 560
  • Inoue M., Tan Y. H. Radioimmunoassay for human beta interferon. Infect. Immunity 1981; 33(3)763
  • World Health Organization. Interferon and other antiviral agents, with special reference to influenza: A memorandum. Bull. WHO 1978; 56: 229
  • Anon. Interferon nomenclature. Nature (London) 1980; 286: 110
  • Anon. Interferon standards: A memorandum. J. Biol. Stand. 1979; 7: 383
  • Report of WHO Scientific Group. Interferon therapy. Tech. Rep. Ser. 676, Worth Health Organization, Geneva 1982; 1
  • Isaacs D., Clarke J. R., Tyrrell D. A. J., Webster A. D. B., Valman H. F. Deficient production of leucocyte interferon (interferon-) in vitro and in vivo in children with recurrent respiratory tract infections. Lancet 1981; 950
  • Isaacs A., Burke D. C. Mode of action of interferon. Nature (London) 1958; 182: 1073
  • Isaacs A., Lindemann J. D. Virus interference. I. Proc. Soc. Ser. B 1957; 147: 258
  • Isaacs A., Westwood M. A. Duration of protective action of interferon against infection with West Nile Virus. Nature (London) 1959; 184: 1232
  • Izadkhah Z., Mandel A. D., Sonnenfeld G. Effect of treatment of mice with sera containing gamma interferon on the course of infection with Salmonella typhimurium Strain LT-2. J. Interferon Res. 1980; 1: 137
  • Jameson P., Dixon M., Grossberg S. E. A sensitive interferon assay for many species of cells. Encephalomyocarditis virus hemagglutinin yield reduction. Proc. Soc. Biol. Med. 1977; 155: 173
  • Jameson P., Schoenherr C. K., Grossberg S. E. Blue-tongue virus, an exceptionally potent interferon inducer in mice. Infect. Immunity 1978; 20: 321
  • Jesse R. H. Cancer of the Head and Neck, J. Y. Sven, E. N. Meyers. Churchill Livingstone, New York 1981; 10
  • Joklik W. K. The molecular basis of the antiviral activity of interferons—introductory remarks. Ann. N.Y. Acad. Sci. 1980; 350: 432
  • Joklik W. K., Merigan T. C. Concerning the mechanism of action of interferon. Proc. Natl. Acad. Sci. 1966; 56: 558
  • Jones B. R., Coster D. J., Falcon M. G., Cantell K. Clinical trials of topical interferon therapy of ulcerative viral keratitis. J. Infect. Dis. 1976; 113(A)169
  • Jordan G. W., Fried R. P., Merigan T. C. Administration of human leukocyte interferon in Herpes zoster. I. Safety, circulating, antiviral activity, and host responses to infection. J. Infect. Dis. 1974; 130: 56
  • Kadish A. S., Doyle A. T., Steinhauer E. H., Ghossein N. A. Natural cytotoxicity and interferon production in human cancer: deficient natural killer activity and normal interferon production in patients with advanced disease. J. Immunol. 1981; 127(5)1817
  • Kaempfer R., Israeli R., Roen H., Knoller S., Zilberstein A., Schmidt A., Revel M. Reversal of the interferon-induced block of protein synthesis by purified preparations of eukaryotic initiation factor 2. Virology 1979; 99: 179
  • Keay S., Grossberg S. E. Interferon inhibits the conversion of 3T3 L1 mouse fibroblasts into adipocytes. Proc. Natl. Acad. Sci. 1980; 77: 4099
  • Kelsey D. K., Overall J. C., Jr., Glasgow L. A. Production of alpha and gamma interferons by spleen cells from cytomegalovirus-infected mice. Infect. Immunity 1982; 36(2)651
  • Kerr I. M., Brown R. E., Ball L. A. Increased sensitivity to double-stranded RNA of protein synthesis in cell-free systems from interferon-treated cells. Nature (London) 1974; 250: 57
  • Kerr I. M., Brown R. E., Hovanessian H. E. Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA. Nature (London) 1977; 268: 540
  • Kerr I. M., Brown R. E. pppA2′p5′A2′p5′ A: An inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells. Proc. Natl. Acad. Sci. 1978; 15: 256
  • Killender D., Lindahl P., Lundin L., Leary P., Cresser I. Relationship between the enhanced expression of histocompatibility antigens on interferon-treated L1210 cells and their position in the cell cycle. Eur. J. Immunol. 1976; 6: 56
  • Klinkert W. E. F., LaBadie J. H., O'Brien J. P., Beyer C. F., Bowers W. E. Rat dendritic cells function as accessory cells and control the production of a soluble factor required for mitogenic responses of T lymphocytes. Proc. Natl. Acad. Sci. 1980; 77: 5414
  • Koren H. S., Anderson S. J., Fischer D. G., Copeland C. S., Jensen P. J. Regulation of human natural killing. J. Immunol. 1981; 127(6)2207
  • Korsaris A., Karemfillis T., Koliais S. I., Taylor-Papadimitriou J. Mitochondrial protein synthesis is inhibited by 2′–5′ linked oligoadenylic acid triphosphate. Biochem. Biophys. Res. Commun. 1980; 96: 1466
  • Kortsaris A., Taylor-Papadimitriou J., Georgatsos J. G. Interferon inhibition of protein synthesis by isolated mitochondria. Biochem. Biophys. Res. Commun. 1976; 68(4)1317
  • Koshland D. E., Jr., Nemethy G., Filmer D. Comparison of experimental binding data and theoretical models in proteins containing subunits. Biochemistry 1966; 5: 365
  • Krim M. Towards tumor therapy with interferons. I. Interferons: production and properties. Blood 1980; 55: 711
  • Kushnaryov V. M., Sedmak J. J., Bendler J. W., III, Grossberg S. E. Ultrastructural localization of interferon receptors on the surfaces of cultured cells and erythrocytes. Infect. Immunity 1981; 36(2)811
  • Kuwata T., Fuse A., Suzzuki N., Morinaga N. Comparison of the suppression of cell and virus growth in transformed human cells by leukocyte and fibroblast interferon. J. Gen. Virol. 1979; 43: 435
  • Lebon P., Girard S., Thepot F., Chancy C. The presence of alpha-interferon in human amniotic fluid. J. Virol. 1982; 59: 393
  • Lambert H. P., Stern H. Infective factors in exacerbations of bronchitis and asthma. Br. Med. J. 1972; 3: 323
  • Lampson G., Tytell A., Field A., Nemesm Hilleman M. Inducers of interferon in host resistance. I. Double-stranded DNA from ext racts of penicillin fenculosom. Proc. Natl. Acad. Sci. 1967; 558: 782
  • Langford M. P., Georgiardes J. A., Stanton G. J., Dianzani F., Johnson H. M. Large-scale production and physico-chemical characterization of human immune interferon. Infect. Immunity 1979; 26: 36
  • Lawrence T. S., Beers W. H., Gilula N. B. Transmission of hormonal stimulation by cell-to-cell communication. Nature (London) 1978; 272: 501
  • Lawrence T. S., Beers W. H. Interferon-induced transfer of viral resistance between animal cells. Nature (London) 1977; 269: 422
  • Leanderson T., Nordfelth R., Lundgren E. Antiproliferative effect of (2′–5′) oligoadenylate distinct from that of interferon in lymphoid cells. Biochem. Biophys. 1982; 107: 511
  • Lebleu B., Sen G. C., Shaila S., Cabrer B., Lengyel P. Interferon, double-stranded RNA, and protein phosphorylation. Proc. Natl. Acad. Sci. 1976; 73: 3107
  • Lee S. H. S., O'Shaughnessy M. V., Rozer K. R. Interferon induced growth depression in diploid and heterploid human cells. Proc. Soc. Exp. Biol. Med. 1972; 139: 1438
  • Legaspi R. C., Catmaitan B., Bailey E. J., Lerner A. M. Interferon in biopsy and autopsy specimens of brain. Its presence in herpes simplex virus encephalitis. Arch. Neural. 1980; 37: 76
  • Lengyel P. Biochemistry of interferons and their actions. Ann. Rev. Biochem. 1982; 51: 251
  • Lenz J. R., Baglioni C. Inhibition of protein synthesis by double-stranded RNA and phosphorylation of initiation factor eIF-2. J. Biol. Chem. 1978; 253: 4219
  • Levine S. Effect of actinomycin D and puromycin dihydrochloride on action of interferon. Virology 1964; 24: 586
  • Levy H. B., Carter W. A. Molecular basis of the action of interferon. J. Mol. Biol. 1968; 31: 561
  • Lewis J. A., Mengheri E., Esteban M. Induction of an antiviral response by interferon requires thymidine kinase. Proc. Natl. Acad. Sci. 1983; 80: 26
  • Lindahl-Magnusson P., Leary P., Gresser I. Interferon inhibits DNA synthesis induced in mouse lympocyte suspensions by phytohaemagglutinin or by allogeneic cells. Nature New Biol. 1972; 237: 120
  • Lundblad D., Lundgren E. Changes in DNA-polymerase and thymidine kinase activity during interferon treatment. Biochem. Biophys. 1982; 105: 1569
  • Lundgren E., Larson I., Miorner H., Strannegard O. Effects of leukocyte and fibroblast interferon on events in the fibroblast cell cycle. J. Gen. Virol. 1979; 42: 589
  • Maheshwari R. K., Streevalsan T., Silverman R. H., Hay J., Friedman R. M. Tunicamycin enhances the antiviral and anticellular activity of interferon. Science 1983; 219: 1339
  • Malek-Mansour S. Immunotherapy of melanoma with 2–4 dinitrochlorobenzene (DNCB). Adjuvant Therapy of Cancer, S. E. Salmon, S. E. Jones. Elsevier/North Holland, Amsterdam 1977; 447
  • Mannering G. S., Renton K. W., Azhary R., Deloria L. B. Effects of interferon inducing agents on hepatic cytochrome P. 450 drug metabolizing system. N.Y. Acad. Sci. 1980; 380: 314
  • Marchinko V. I., Povalatski Y. L., Krivolchatskaya L. D. Interferon producing capacity of human tonsil cells and properties on interferon produced by these cells. Active Virol. 1976; 20: 114
  • Marcus P. I., Terry T. M., Levine S. Interferon action. II. Membrane bound alkaline ribonuclease activity in chick embryo cells manifesting interferon-mediated interference. Proc. Natl. Acad. Sci. 1975; 72: 182
  • McCabe B. F., Clark K. F. Interferon and laryngeal papillomatosis: the Iowa Experience. Ann. Otol. Rhinol. Laryngol. 1983; 92: 2
  • McIntosh K., Ellis E. F., Hoffman L. S., Lybass T. G., Eller J. J., Fulginita V. A. The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J. Pediat. 1973; 82: 578
  • Melder R. J., Ho M. Modulation of natural killer cell activity in mice after interferon induction: depression of activity and depression of in vitro enhancement by interferon. Infect. Immunity 1982; 36(3)990
  • Meldolesi M. F., Friedman R. M., Kohn L. D. Interferon-induced increase in cyclic AMP levels proceeds the establishment of the antiviral state. Biochem. Biophys. Res. Commun. 1977; 79: 239
  • Merigan T. C. Interferon—the first quarter century. JAMA 1982; 248: 2513
  • Meyers J. D., McGuffin R. W., Byerson Y. J., Cantell K., Thomas E. D. Treatment of cytomegalovirus pneumonia after marrow transplant with combined vidarabine and hyman leukocyte interferon. J. Infect. Dis. 1982; 146(1)80
  • Minor T. E., Dick E. C., Baker J. W., Ouellette J. J., Cohen M., Reed C. E. Rhinovirus and influenza type A infections as precipitants of asthma. Am. Rev. Respir. Dis. 1976; 113: 149
  • Misset J. L., Mathe G., Gastiaburu J., Goutner A., Dorval T., Gouveia J., Hayat M., Jasmin C., Schwarzenberg L., Machover D., Ribaud P., De Vassal F., Horoszewicz J. S. Treatment of lymphoid neoplasias with interferon. I. Human fibroblastic β-interferon in malignant gammapathies. Phase II trial. Anticancer Res. 1982; 2: 63
  • Misste J. L., Mathe G., Gastiaburu J., Goutner A., Dorval T., Gouveia J., Hayat M., Jasmin C., Schwarzenberg L., Machover D., Ribaud P., De Vassal F. Treatment of lymphoid neoplasias with interferon. II. Human leucocyte α-interferon in chronic lymphatic leukemia (CLL). Phase I-II trial. Anticancer Res. 1982; 2: 67
  • Miyoshi T., Ogawa S., Kanamori T., Nobuhara M., Namba M. Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originating from neoplastic tissues. Cancer Lett. 1983; 17: 239
  • Morahan P. S., Grossberg S. E. Age-related cellular resistance of the chicken embryo to viral infections. I. Interferon and natural resistance to myxoviruses and vesicular stomatitis virus. J. Infect. Dis. 1970; 121: 615
  • Morahan P. S., Grossberg S. E. Age-related cellular resistance of chicken embryo to viral infections. III. Escherichia coli resistant inducing protein. Proc. Exp. Biol. Med. 1970; 134: 342
  • Nakane A., Minagawa T. Induction of alpha and beta interferons during the hyporeactive state of gamma interferon by mycobacterium bovis BCG cell wall fraction in mycobacterium bovis BCG sensitized mice. Infect. Immunol. 1982; 36: 966
  • Neumann-Haefelin D., Sundmacher R., Skida R., Cantell K. Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model. Infect. Immunol. 1977; 17(2)468
  • Neurath A. R., Strick N., Raj N. B. K., Pitha P. M. Radioimmunoassay of human beta interferon. J. IFN Res. 1982; 2(1)51
  • Ohno S., Kato F., Mutsuda H., Fujii N., Minagawa T. Detection of gamma interferon in the sera of patients with Behcet's disease. Infect. Immunity 1982; 36(1)202
  • Ojo-Amaize E. A., Salimonu L. S., Williams A. I. O., Akinwolere O. A. O., Raad S., Gunnar V. A., Wigzell H. Positive correlation between degree of parasitemia, interferon titers, and natural killer cell activity in Plasmodium falciparum-infected children. J. Immunol. 1981; 127: 2296
  • Oldham R. R. Toxic effects on interferon. Science 1983; 219: 902
  • Ortega J. A., Ma A., Shore N. A., Dukes P., Merigan T. C. Suppressive effect of interferon on erythroid cell proliferation. Exp. Hematol. 1979; 7: 145
  • Panem S., personal communication.
  • Panem S., Vilcek J. Interferon and the cure of cancer. The Atlantic Monthly December, 1982; 82
  • Panje W. R. Regression of head and neck carcinoma with a prostaglandin synthesis inhibitor. Arch. Otolaryngol. 1981; 107: 658
  • Paucker K., Dalton B. J., Ogburn C. A., Torma E. Multiple active sites on human interferon: (interferon antigens/heterospecific protection/rabbit cells/antibodies against interferon/affinity chromatograph). Proc. Natl. Acad. Sci. U.S.A. 1975; 72(11)4587
  • Pazin G. J., Armstrong J. A., Lam M. T., Tarr G. C., Jannetta P. J., Ho M. Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root. N. Engl. J. Med. 1979; 301: 225
  • Pazin G. J., Ho M., Haverkos H. W., Armstrong J. A., Breinig M. C., Wechsler H. L., Arvin A., Merigan T. C., Cantell K. Effects of interferon-alpha on human warts. J. Interferon Res. 1982; 2(2)235
  • Perussia B. Santoli, Daniela, and Trinchieri, Interferon modulation of natural killer cell activity. Ann. N.Y. Acad. Sci. 1980; 350: 55
  • Pfeffer L. M., Wang E., Tamm I. Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts. J. Cell. Biol. 1980; 85: 9
  • Pfeffer L. M., Murphy J. S., Tamm I. Interferon effects on the growth and division of human fibroblasts. Exp. Cell. Res. 1979; 121: 111
  • Pickering L. A., Kronenberg L. H., Stewart W. E. II, Spontaneous production of human interferon. Proc. Natl. Acad. Sci. 1980; 77(10)5938
  • Ponzio N. M., Fitzgerald K. L. Spontaneous production of T (Type II) interferon by a murine reticulum-cell sarcoma. N.Y. Acad. Sci. 1980; 350: 157
  • Pouillart P., Palangie T., Jouve M., Garcia-Giralt E., Fridman W. H., Magdelenat H., Falcoff E., Billiaus A. Administration of fibroblast interferon to patients with advanced breast cancer: possible effects on skin metastasis and on hormone receptors. Eur. J. Cancer Clin. Oncol. 1982; 18: 929
  • Preble O. T., Klippel J. H., Koffler D., Vilcek J., Friedman R. M. Interferon in systemic lupus erythematosus (Abstr. #0237). J. Cell Biochem. 1982; 6: 86
  • Preble O. T., Black R. J., Friedman R. M. Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon. Science 1982; 216: 429
  • Preble O. T., Costello L. E., Huang D. D., Barmada M. A. Neurovirulence mutant of vesicular stomatitis virus with an altered target cell tropism in vivo. Infect. Immunol. 1980; 29: 744
  • Priestman T. J. Interferon: an anti-cancer agent?. Cancer Treat Rev. 1979; 6: 223
  • Quesada J. R., Swanson D. A., Trindade A., Gutterman J. U. Renal cell carcinoma: antitumor effects of leukocyte interferon. Cancer Res. 1983; 43: 940
  • Ratner L., Weigand R. C., Farrell P. J., Sen G. C., Cabrer B., Lengyel P. Interferon, double-stranded RNA and RNA degradation. Fractionation of the endo-nuclease system into two macromolecular components: role of a small molecule INT in nuclease activation. Biochem. Biophys. Res. Commun. 1978; 81: 947
  • Revel M., Kimchi A., Shulman L., Fradin A., Shuster R., Yakobson E., Chernajovsky Y., Schmidt A., Shure A., Bendori R. Role of interferon-induced enzymes in the antiviral and antimitogenic effects of interferon. Conf. of regulatory functions of interferons. Ann. N.Y. Acad. Sci. 1980; 350: 459
  • Riccardi C., Vose B. M., Herberman R. B. Modulation of IL 2-dependent growth of mouse NK cells by interferon and T lymphocytes. J. Immunol., 130: 228
  • Rich S. A. Human lupus inclusions and interferon. Science 1981; 213: 772
  • Rich S. A., Owens T. B. Inducibility of human lupus inclusions of interferons (Abstr. 0279). J. Cell Biochem. 1982; 6(Suppl.)101
  • Richtsmeier W. J., Grossberg S. E. The effects of mitochondrial metabolic inhibitors of interferon action (Abstr. 0257). J. Cell. Biochem. 1982; 6(Suppl.)94
  • Richtsmeier W. J. Human interferon production in tonsil and adenoid tissue cultures. J. Am. Acad. Otolaryngol. Head Neck Surg. 1981; 89: 130, (Abstr); Am. J. Otolaryngol., 4, 325, 1983
  • Richtsmeier W. J., Bowers W. E. Human tonsil and adenoid dendritic cells control IFN-γ production, unpublished results
  • Ristow S. S., Starkey J. R., Hass G. M. Inhibition of natural killer cell activity in vitro by alcohols. Biochem. Biophys. Res. Commun. 1982; 105(4)1315
  • Roberts W. K., Hovanessian A., Brown R. E., Clemens M. J., Kerr I. M. Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis. Nature (London) 1976; 264: 477
  • Rossi G. B., Dolei A., Capobianchi M. R., Peschle C., Affabris E. Interactions of interferon with in vitro model systems involved in hematopoietic cell differentiation. Ann. N.Y. Acad. Sci. 1980; 350: 279
  • Rubinstein S., Familletti C., Pestka S. Convenient assay for interferons. J. Virol. 1981; 37(2)755
  • Saksela E., Timonen T. Cellular interactions in the augmentation of human NK activity by interferon. Ann. N.Y. Acad. Sci. 1980; 350: 102
  • Samuel C. E., Farris D. A., Eppstein D. A. Mechanism of interferon action. Kinetics of interferon action in mouse L929 cells: translation inhibition, protein phosphorylation, and messenger RNA methylation and degradation. Virology 1977; 83: 56
  • Samuel C. E., Joklik W. K. A protein synthesizing system from interferon-treated cells that discriminates between cellular and viral messenger RNAs. Virology 1974; 58: 476
  • Samuel C. E., Kingsman S. M., Melamed R. W., Farris D. A., Smith M. D., Miyamoto N. G., Lasky S. R., Knutson G. S. Mechanism of interferon-mediated inhibition of protein synthesis. Ann. N.Y. Acad. Sci. 1980; 350: 473
  • Samuel C. E. Mechanism of interferon action. Kinetics of interferon action in mouse L929 cells: phosphorylation of protein synthesis initiation factor eIF-2 and ribosome-associated protein P1. Virology 1979; 93: 281
  • Samuel C. E. Mechanism of interferon action. Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase possessing site-specificity similar to the hemin-regulated rabbit reticulocyte kinase. Proc. Natl. Acad. Sci. 1979; 76: 600
  • Sanders C. V., Luby J. P., Sanford J. P., Hull A. R. Suppression of interferon response in lymphocytes from patients with uremia. J. Lab. Clin. Med. 1977; 77: 786
  • Saneto R., Johnson H. M. Interferon inhibition of hexose monophosphate shunt activity as the mechanism of blocking differentiation of a preadipose cell line. Biochem. Biophys. Res. Commun. 1982; 106: 373
  • Santoli D., Trinchieri G., Lief F. S. Cell-mediated cytoxicity against virus-infected target cells in humans. I. Characterization of the effector lymphocyte. J. Immunol. 1978; 121: 526
  • Santoli D., Trinchierei G., Koprowski H. Cell-mediated cytoxicity in humans against virus-infected target cells. II. Interferon induction and activation of natural killer cells. J. Immunol. 1978; 121: 532
  • Schattner A., Merlin G., Levin S., Wallach D., Hahn T., Revel M. Assay of an interferon-induced enzyme in white blood cells as a diganostic aid in viral diseases. Lancet 1981; 2: 497
  • Schattner A., Merlin G., Wallach D., Rosenberg H., Bino T., Hahn T., Levin S., Revel M. Monitoring of interferon therapy by assay of (2′–5′) oligo-isoadenylate synthetase in human peripheral white blood cells. J. Interferon Res. 1981; 1(4)587
  • Schouten T. J., Weimar W., Bos J. H., Box C. E., Cremers C. W., Schellekens H. Treatment of juvenile laryngeal papillomatosis with two types of interferon. Laryngoscope 1982; 92: 686
  • Schouten T. J., van den Broek P., Cremers, Cor W. R. J., Jongerius C. M., Meyer J. W. R., Vooys G. P. Interferons and bronchogenic charcinoma, in Juvenile Laryngeal Papillomatosis. Arch. Otolaryngol 1983; 109: 289
  • Scorticatti C., DeLa Pena N. C., Bellora O. C., Mariotto R. A., Casabe A. R., Comilli R. Systemic IFN-alpha treatment of multiple bladder papilloma grade I or II patients: pilot study. J. Interferon Res. 1982; 2(3)339
  • Scott G. M., Sceher D. S., Flowers D., et al. Clinical toxicity of interferon. Br. Med. J. 1981; 282: 1345
  • Scott G. M., Tyrrell D. A. J. Interferon: therapeutic fact or ′80s?. Br. Med. J. 1980; 280: 1558
  • Scott G. M., Wallace J., Greiner J., Phillpotts R. J., Cauci C. L., Tyrrell D. A. J. Prevention of rhinohuman interferon alpha-s from Escherichia coli. Lancet 1982; 186
  • Scott G. M., Secher D. S., Flowers D., et al. Clinical toxicity of interferon. Br. Med. J. 1981; 288: 1345
  • Schullard G. H., Pollard R. B., Smith J. L., Sacks S. L., Gregory P. B., Robinson W. S., Merigan T. C. Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside. J. Infect. Dis. 1981; 143: 772
  • Sedmak J. J., Grossberg S. E., Jameson P. The neuraminidase yield-reduction bioassay of human and other interferons (38822). Proc. Soc. Exp. Biol. Med. 1975; 149: 433
  • Sehgal P. B., Sager A. D., Braude I. A. Further heterogencity of human interferon mRNA species. Science 1981; 214: 803
  • Sergiescu D., Cerutti I., Efthymiou E., Kahan A., Chany C. Adverse effects of interferon treatment on the life span of NZB mice. Biomedicine, 31: 48
  • Sherwin S. A., Knost J. A., Fein S., Abrams P. G., Foon K. A., Ochs J. J., Schoenberger C., Maluish A. E., Oldham R. K. A multiple-dose phase I trial of recombinant leukocyte A interferon in cancer patients. JAMA 1982; 248: 2461
  • Siegal G. P., Thorgeirsson U. P., Russo R. G., Wallace D. M., Liotta L. A., Berger S. L. Interferon enhancement of the invasive capacity of Ewing sarcoma cells in vitro. Proc. Natl. Acad. Sci. 1982; 79: 4064
  • Sikora K., Smedley H. Interferon and cancer. Br. Med. J. 1983; 286: 739
  • Singh G., Renton K. W., Stebbing N. Homogeneous interferon from E. coli depresses hepatic cytochrome P-450 and drug biotransformation. Biochem. Biophys. Res. Commun. 1982; 106: 1256
  • Slimmer S., Masui H., Kaplan N. O. Antiproliferative assay for human interferons. Methods Enzymol. 1981; 79: 419
  • Smedley H., Katrak M., Sikora K., Wheeler T. Neurological effects of recombinant human interferon. Br. Med. J. 1983; 286: 262
  • Smith E. M., Johnson H. M., Blalock J. E. Staphyloccus aureus protein A induces the production of interferon-α in human lymphocytes and interferon-α/β in mouse spleen cells. J. Immunol. 1983; 130: 773
  • Soloviev V. D. The results of controlled observations on the prophylaxis of influenza with interferon. Bull. WHO 1969; 41: 683
  • Sonnenfeld G., Kierszenbaum F. Increased serum levels of an interferon-like activity during the acute period of experimental infection with different strains of Trypanosoma cruzi. Am. J. Trop. Med. Hyg. 1981; 30: 1189
  • Spruance S. L., Green J. A., Chiu G., Yeh T., Wenerstrom G., Overall J. C., Jr. Pathogenesis of herpes simplex labialis: correlation of vesicle fluid interferon with lesion age and virus titer. Infect. Immunity 1982; 36(3)907
  • Stiehm E. R., Kronenberg L. H., Rosenblatt H. M., Bryson Y., Merigan T. C. Interferon: immunobiology and clinical significance, UCLA Conf. Ann. Int. Med. 1982; 96: 80
  • Stinebring W., Youngner J. Patterns of interferon appearance in mice injected with bacteria or bacterial endotoxin. Nature (London) 1964; 204: 1712
  • Strander H., Cantell K. Production of interferon by human leukocytes in vitro. Ann. Med. Exp. Biol. Fenn. 1966; 44: 265
  • Strander H., Einhorn S. Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture. Int. J. Cancer 1977; 19: 468
  • Sundmacher R., Cantell K., Neumann-Haefelin D. Combination therapy of dendritic keratitis with trifluorothymidine and interferon. Lancet 1978; 2(8091)687
  • Sundmacher A., Neumann-Haefelin D., Cantell K. Interferon treatment of dendritic keratitis. Lancet. 1976; 1186
  • Sunkara P. S., Prakash N. J., Mayer G. D., Sjoerdsma A. Tumor suppression with a combination of α-difluoromethyl omithine and interferon. Science 1983; 219: 851
  • Taylor J. Inhibition of interferon action by actinomycin. Biochem. Biophys. Res. Commun. 1964; 14: 447
  • Taylor-Papadimitriou J. The effects of interferon on cell growth and function. Interferon II, I. N. Gressor. Academic Press, New York 1980; 2
  • Taylor-Papadimitriou J., Shearer M., Rozengurt E. Inhibitory effect of interferon on cellular DNA synthesis: modulation by pure mitogenic factors. J. Interferon Res. 1981; 1: 401
  • Taylor J. L., Sabran J. L., Grossberg S. E. Cellular effects of interferon. Handbook of Experimental Pharmacology. Springer-Verlag, Basel 1982
  • Taylor J. L., Schoenherr C. K., Grossberg S. E. High-yield interferon induction by 1-carboxymethyl-9-acridanone in mice and hamsters. Antimicrob. Agents Chemother. 1980; 18: 20
  • Tomida M., Yamamoto Y., Hozumi M. Stimulation by interferon of induction of differentiation of mouse myeloid leukemic cells. Cancer Res. 1980; 40: 2919
  • Treuner J., Niethammer D., Dannecker G., Hagmann R., Neef V., Hofschneider P. H. Successful treatment of nasopharyngeal carcinoma with interferon (letter to the Ed.). Lancet 1980; 817
  • Trinchieri G., Santoli D. Antiviral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human NK cell activity by IFN and antagonistic inhibition of susceptibility of target cells to lysis. J. Exp. Med. 1978; 147: 1314
  • Trinchieri G., Santoli D., Knowles B. B. Tumor all lines induce interferon in human lymphocytes. Nature (London) 1977; 270: 611
  • Trinchierei G., Santoli D., Koprowski H. Spontaneous cell-mediated cytoxicity in humans: role of IFN and immunoglobins. J. Immunol. 1978; 120: 1849
  • Trinchierei G., Santoli D., Granato D., Perussia B. Antagonistic effects of interferon on the cytoxicity mediated by natural killer cells. Fed. Proc. 1981; 40: 2705
  • Trying S., Klimpel G. R., Fleischmann W. R., Baron S. Direct cytolysis by partially purified preparations of immune interferon. Int. J. Cancer 1982; 30: 59
  • Vallbracht A., Treuner J., Flehmig B., Joester K. E., Niethammer D. Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon. Nature (London) 1981; 289: 496
  • Vallbracht A., Treuner J., Manncke K. H., Niethammer D. Autoantibodies against human beta interferon following treatment with interferon. J. IFN Res. 1982; 2: 107
  • Vengris V. E., Stollar B. D., Pitha P. M. Interferon externalization by producing cell before induction of antiviral state. Virology 1975; 65: 410
  • Vianna N. J., Davies J. N., Harris S., Lawrence C. E., Arbuckle J., Marani W., Wilkinson J. Tonsillectomy and childhood Hodgkins disease. Lancet August 16, 1980
  • Vilcek J. Interferon as a cell product. Adv. Exp. Med. Biol. 1979; 118: 117
  • Vilcik J., Gresser I., Merigan T. C. Eds., Opening remarks—regulatory functions of interferons. Ann. N.Y. Acad. Sci. 1980; 350: 13
  • Vose B. M., Riccardi C., Bonard G. D., Herberman R. R. Limiting dilution analysis of the frequency of human T cells and large granular lymphocytes proliferating in response to interleukin 2. J. Immunol. 1983; 130: 768
  • Werenne J., Emonds-Alt X., Bartholeyns J. Interferon regulates cell motility. Ann. N.Y. Acad. Sci. 1980; 350: 623
  • Wiebe M. E., Joklik W. K. The mechanism of inhibition of renovirus replication by interferon. Virology 1975; 66: 229
  • Williams H., McNicol K. N. Prevalence, natural history, and relationship of wheezy bronchitis and asthma in children: An epidemiological study. Br. Med. J. 1969; 9: 321
  • Wong T. W., Klinkert W. E. F., Bowers W. E. Immunological properties of thymus cell subpopulations: rat thymic dendritic cells are potent accessory cells and stimulators in a mixed leukocyte culture. Immunobiology 1982; 160: 413
  • Wyler D. J., Liang L., Downey E., Krim M. Exogenous interferon administration in experimental Leishmaniasis: in vivo and in vitro studies. Am. J. Trop. Med Hyg. 1982; 3(4)740
  • Yabrov A. A. Interferon and Non-specific Resistance. Human Sciences Press, New York 1980; 29
  • Yaron M., Yaron I., Gurari-Rotman D., Revel M., Lindner H. R., Zor U. Stimulation of prostaglandin E production in cultured human fibroblasts by poly (I)-poly (C) and human interferon. Nature (London) 1977; 267: 4557
  • Ytterberg S. R., Schnitzer T. J. Serum interferon levels in patients with systemic lupus erythematosus. Arthritis Rheum. Apr. 1982; 25: 401
  • Zawatzky R., Gresser I., DcMaeyer E., Kirchner H. The role of interferon in the resistance of C57BL/6 mice to various doses of herpes simplex virus type I. J. Infect. Dis. 1982; 146: 405
  • Zilberstein A., Federman J. P., Shulman L., Revel M. Specific phosphorylation in vitro of a protein associated with ribosomes of interferon-treated mouse cells. FEBS Lett. 1976; 68: 119

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