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Original Article

Differential Laboratory Diagnosis of Hypercalcemia

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Pages 51-97 | Published online: 02 Jul 2009

References

  • Toffaletti J., McComb R. B., Bowers G. N., Jr. Increase in dialyzable calcium associated with therapy with lithium. Clin. Chem. 1979; 25: 1806
  • Josephson B., Dahlberg G. Variations in the cell content and chemical composition of human blood due to age sex and season. Scand. J. Clin. Lab. Invest. 1952; 4: 216
  • McLean F. C., Hastings A. B. Chemical estimation and significance of calcium ion concentrations in the blood. Am. J. Med. Sci. 1935; 189: 601
  • Kramer B., Tisdall F. F. The direct quantitative determination of sodium potassium and calcium and magnesium in small amounts of blood. Biol. Chem. 1921; 47: 475
  • Clark E. P., Collip J. B. A study of the Tisdall method for the determination of blood serum calcium with a suggested modification. J. Biol. Chem. 1925; 63: 461
  • Berger E. Y. Calcium determination in biologic material. Clin. Chem. 1955; 1: 249
  • Bachra B. N., Dauer A., Sobel A. E. The complexometric titration of micro and ultramicro quantities of calcium in blood serum urine and inorganic salt solutions. Clin. Chem. 1958; 4: 107
  • Kesler G., Wolfman M. An automated procedure for the simultaneous determination of calcium and phosphorus. Clin. Chem. 1964; 10: 686
  • Flynn F. V., Piper K. A. J., Garcia-Webb P., McPherson K., Healy M. J. R. Biological and analytical variation of commonly determined blood constituents in healthy blood donors. Clin. Chim. Acta 1976; 70: 179
  • Barrett A. E., Cameron S. J., Frazer C. G., Penberthy L. A., Shand K. L. A clinical view of analytical goals in clinical biochemistry. J. Clin. Pathol. 1979; 32: 893
  • Hald P. M., Eisenman A. J. The distribution of bases between cells and serum of normal human blood. J. Biol. Chem. 1937; 118: 275
  • Stuzman F., Amatuzio D. S. A study of serum and spinal fluid calcium and magnesium in normal humans. Arch. Biochem. Biophys. 1952; 39: 271
  • Sunderman F. W. Studies of serum electrolytes. The total base and protein components of the serum during lobar pneumonia with a note on the gastric secretion. J. Clin. Invest. 1931; 9: 615
  • Wootton I. D. P., King E. J. Normal values for blood constituents. Inter-hospital differences. Lancet 1953; 4: 470
  • Burke M. D. Calcium and phosphorus studies. Interpretation of results and strategies for further testing. Postgrad. Med. J. 1980; 68: 69
  • Kelly A., Munan L., Petit Clare C., Ping Ho K., Billon B. Use of values for calcium and protein in serum and of a derived index obtained from a probability population sample. Clin. Chem. 1976; 22: 1723
  • Monchik J. M., Martin H. F. Ionized calcium in the diagnosis of primary hyperparathyroidism. Surgery 1980; 88: 185
  • Conceicao S. C., Weightaman D., Smith P. A., Luno J., Ward M. K., Kerr D. N. S. Serum ionised calcium concentration: measurement vs. calculation. Br. Med. J. 1978; 1: 1103
  • Pederson K. O. Protein bound calcium in human serum. Quantitative examination of binding and its variables by a monecular binding model and clinical chemical implications for the measurement of molecular ionised calcium. Scand. J. Clin. Lab. Invest. 1972; 30: 321
  • Duncan P. H., Wills M. R., Smith B. J., Savory J. Clinical studies of protein bound calcium in various diseases. Clin. Chem. 1982; 28: 672
  • Payne R. B., Little A. J., Williams R. B., Milner J. R. Interpretation of serum calcium in patients with abnormal serum proteins. Br. Med. J. 1973; 4: 643
  • Berry E. M., Gupta M. M., Turner S. J., Burns R. R. Variation in plasma calcium with induced changes in plasma specific gravity, total protein and albumin. Br. Med. J. 1973; 4: 640
  • Orrell D. H. Albumin as an aid to the interpretation of serum calcium. Clin. Chim. Acta 1971; 35: 483
  • Larrson L., Ohman S. Serum ionized calcium and corrected total calcium in borderline hyperparathyroidism. Clin. Chem. 1978; 24: 1962
  • Pain R. W., Phillips P. J. Adjustment of serum calcium for protein. Clin. Chem. 1976; 22: 282
  • Payne R. B., Little A. J. Adjusting serum calcium for protein. Clin. Chem. 1976; 22: 933
  • Payne R. B., Carver M. E., Morgan D. B. Interpretation of serum total calcium, effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in an individual. J. Clin. Pathol. 1979; 32: 56
  • Husdan H., Rapoport A., Locke S., Oreopoulos D. Effect of venous occlusion of the arm on the concentration of calcium in serum and methods for its compensation. Clin. Chem. 1974; 20: 529
  • Parfitt A. M. Chlorothiazide induced hypercalcemia in juvenile osteoporosis and hyperparathyroidism. N. Engl. J. Med. 1969; 281: 55
  • Dent C. E. Some problems of hyperparathyroidism. Br. Med. J. 1962; 11: 1419
  • Payne R. B., Walker B. E. Serum calcium. Lancet 1979; 1: 1248
  • Poltgen P., Davis E. R. Why measure total serum Ca?. Clin. Chem. 1976; 22: 1752
  • Shimerdiak W. P., Kukreja C. S., Lad T. E., York P. A. J., Henderson W. J. Evaluation of routine ionised calcium determination in cancer patents. Clin. Chem. 1981; 27: 1621
  • Ladenson J. H., Lewis J. W., Boyd J. C. Failure of total calcium corrected for protein albumin and pH to correctly assess free calcium status. J. Clin. Endocrinol. Metab. 1978; 46: 986
  • Lloyd A. M., Rose G. A. Ionized, protein-bound, and complexed calcium in primary hyperparathyroidism. Lancet 1958; 2: 1258
  • Low J. C., Schaaf M., Earll J. M., Piechocki J. T., Ting-Kai Li. Ionic calcium determination in primary hyperparathyroidism. JAMA 1973; 223: 152
  • Edmonson J. W., Ting-Kai Li. The relationship of serum ionized and total calcium in primary hyperparathyroidism. J. Lab. Clin. Med. 1976; 87: 624
  • Bergman L., Isaaksson B. Plasma calcium fractions in normal subjects from birth to adult ages. Acta Paediatr. Scand. 1997; 60: 630
  • Butler S. J., Payne R. B. Nova 2 Ionised calcium analyzer, imprecision, bias and protein interference. Clin. Chem. 1983; 29: 585
  • Farr H. W. Hyperparathyroidism and cancer. CA; Cancer J. Clin. 1976; 20: 66
  • Heath H., III, Hodgson S. F., Kennedy M. A. Primary hyperparathyroidism. Incidence morbidity and potential economic impact on a community. N. Engl. J. Med. 1980; 302: 189
  • Boonstra C. E., Jackson C. E. Hyperparathyroidism detected by routine serum calcium analysis. Prevalence in a clinic population. Ann. Intern. Med. 1965; 63: 468
  • Christensson T., Hellstrom K., Wengle B., et al. Prevalence of hypercalcemia in health screening in Stockholm. Acta Med. Scand. 1976; 200: 131
  • Mundy G. R., Cove D. H., Fisken R. Primary hyperparathyroidism changes in the pattern of clinical presentation. Lancet 1980; 1: 1317
  • Johnson K. R., Howarth A. T., Hamilton M., Mascall G. C. Laboratory differentiation of hypercalcemic patients. Clin. Chem. 1982; 28: 333
  • Boonstra C. E., Jackson C. E. Serum calcium survey for hyperparthyroidism. Am. J. Clin. Pathol. 1971; 55: 523
  • Coe F. L., Favus J. Does mild asymptomatic hyperparathyroidism require surgery?. N. Engl. J. Med. 1980; 302: 224
  • Strott C. A., Nugent C. A. Laboratory tests in the diagnosis of hyperparathyroidism in hypercalcemic patients. Ann. Intern. Med. 1968; 68: 188
  • Heath D. A., Wright A. D., Oates G. D., Dorricott W. J. Surgical treatment of primary hyperparathyroidism in the elderly. Br. Med. J. 1980; 280: 1406
  • Christensson T., Hellstrom K., Wengle B., et al. Blood pressure in subjects with hypercalcemia and primary hyperparathyroidism detected in a health screening programme. Eur. J. Clin. Invest. 1977; 7: 109
  • Lafferty F. W. Primary hyperparathyroidism. Changing clinical spectrum, prevalence of hypertension and discriminant analysis of laboratory tests. Arch. Intern. Med. 1981; 141: 1761
  • Kaplan R. A., Snyder W. H., Stewart A., et al. Metabolic effects of parathyroidectomy in asymptomatic primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 1976; 42: 415
  • Alveryd A., Bostrom H., Wengle B., Webster P. O. Indications for surgery in the elderly patient with primary hyperparathyroidism. Acta Chir. Scand. 1976; 142: 491
  • Hecht A., Gershberg H., St. Paul H. Primary hyperparathyroidism. Laboratory and clinical data in 73 cases. JAMA 1975; 233: 519
  • Editorial. Diagnosis and treatment of primary hyperparathyroidism. Lancet 1980; 1: 1339
  • Purnell D. C., Scholz D. A., Smith L. H., et al. Treatment of primary hyperparathyroidism. Am. J. Med. 1974; 56: 800
  • Raisz L. G. The diagnosis of hyperparathyroidism. N. Engl. J. Med. 1971; 285: 1006
  • Eisenberg E., Gotch C. Normocalcemic hyperparathyroidism culminating in hypercalcemic crisis; treatment with haemodialysis. Arch. Intern. Med. 1968; 122: 258
  • Posen S., Kleerekoper M., Ingham J. P., Hirshorn J. E. Parathyroid hormone assay in clinical decision making. Br. Med. J. 1976; 1: 16
  • Gutman A. B., Tyson T. L., Gutman E. B. Serum calcium inorganic phosphorus and phosphatase activity in hyperparathyroidism. Paget's disease, multiple myeloma and neoplastic disease of the bones. Arch. Intern. Med. 1936; 57: 379
  • Woodard H. W. Changes in blood chemistry associated with carcinoma metastatic to bone. Cancer 1953; 6: 1219
  • Kleinfeld G. Acute fatal hypercalcemia. JAMA 1962; 181: 1137
  • Swaroop S., Krant M. J. Rapid estrogen-induced hypercalcemia. JAMA 1973; 223: 913
  • Warwick O. H., Yendt E. R., Olin J. A. The clinical features of hypercalcemia associated with malignant disease. Can. Med. Assoc. J. 1961; 85: 719
  • Goldberg M. F., Tashjian A. H., Order S. E., Dammin G. J. Renal adenocarcinoma containing a parathyroid hormone-like substance and associated with marked hypercalcemia. Am. J. Med. 1964; 36: 805
  • Lafferty F. W. Pseudohyperparathyroidism. Medicine 1966; 45: 247
  • Gordan G. S., Eisenber E., Loken H. F., et al. Clinical endocrinology of parathyroid hormone excess. Recent Prog. Horm. Res. 1962; 18: 297
  • Chopra D. P. Hypercalcemia and malignant disease. Med. Clin. N. Am. 1975; 59(2)
  • Lee D. B. N., Zawada E. T., Kleeman C. R. The pathophysiology and clinical aspects of hypercalcemia disorders (medical progress). Est. J. Med. 1978; 129: 278
  • Thomas A. N., Loken H. F., Gordan G. S., et al. Hypercalcemia of metastatic breast cancer. Surg. Forum 1960; 11: 70
  • Gardner B., Graham W. P., Gordon G. S., et al. Calcium and phosphate metabolism in patients with disseminated breast cancer. Effect of androgens and of prednisone. J. Clin. Endocrinol. 1963; 23: 115
  • Jessiman A. G., Emersen J., Jr., Shar R. C., et al. Hypercalcemia in carcinoma of the breast. Ann. Surg. 1963; 157: 377
  • Bender R. A., Hansen H. Hypercalcemia in bronchogenic carcinoma. A prospective study of 200 patients. Ann. Intern. Med. 1974; 80: 205
  • Warren M. M., Utz D. C., Kelalis P. P. Concurrence of hypernephroma and hypercalcemia. Ann. Surg. 1971; 174: 863
  • Fisken R. A., Heath D. A., Bold A. M. Hypercalcemia—a hospital survey. Q. J. Med. New Ser. XLIX 1980; 196: 405
  • McLellan G., Baird C. W., Melick R. Hypercalcemia in an Australian hospital adult population. Med. J. Aust. 1968; 2: 354
  • Heath D. A. Hypercalcemia and malignancy. Ann. Clin. Biochem. 1976; 13: 555
  • Myers W. P. L. Hypercalcemia in neoplastic disease. Arch. Surg. 1960; 80: 308
  • Delamore I. W. Hypercalcemia and myeloma. Br. J. Haematol. 1982; 5: 507
  • Albright F., Burnett C. H., Cope O., Parson W. Acute atrophy of bone (osteoporosis) simulating hyperparathyroidism. J. Clin. Endocrinol. Metab. 1941; 1: 711
  • Becker D. J., Sternberg M. S., Kalser M. H. Hepatoma associated with hypercalcemia. JAMA 1963; 186: 1018
  • Berson S. A., Yalow R. S. Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia and bronchogenic carcinoma. Science 1966; 154: 907
  • Connor T. B., Thomas W. C., Howard J. E. Etiology of hypercalcemia associated with lung carcinoma. J. Clin. Invest. 1956; 35: 697
  • Plimpton C. H., Gelhorn A. Hypercalcemia in malignant disease without evidence of bone destruction. Am. J. Med. 1956; 21: 750
  • Mavligit G. M., Cohen J. L., Sherwood L. Ectopic production of parathyroid hormone by carcinoma of the breast. N. Engl. J. Med. 1971; 285: 154
  • Benson R. C., et al. Immunoreactive forms of circulating parathyroid hormone in primary and ectopic hyperparathyroidism. J. Clin. Invest. 1974; 54: 175
  • Jayaraman J., David R. Hypercalcemia as a presenting manifestation of leukemia: evidence of excessive parathormone secretion. J. Pediatr. 1977; 90: 60
  • Libnoch J. A., Ajlouni K., Millman W. L., et al. Acute myelofibrosis and malignant hypercalcemia. Am. J. Med. 1977; 62: 432
  • Powell D., Murray T. M., Pollard J. J., et al. Parathyroid localization using venous catheterization and radioimmunoassay. Arch. Intern. Med. 1973; 131: 645
  • Riggs B. L., Arnaud C. D., Reynolds J. C., Smith L. H. Immunological differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonhyperparathyroid cancer. J. Clin. Endocrinol. Metab. 1968; 28: 1037
  • DiBella F. P., Kehrwald J. M., Laakso K., Zitner L. Parathyrin radioimmunoassay diagnostic utility of antisera produced against C terminal fragments of the hormone from the human. Clin. Chem. 1978; 24: 451
  • Raisz L. G., Yandick C., Bockman R. S., Bower B. F. Comparison of commercially available parathyroid hormone immunoassays in the differential diagnosis of hypercalcemia due to primary hyperparathyroidism and malignancy. Ann. Intern. Med. 1979; 91: 739
  • Almquist S., Hjern B., Wasthed B. The diagnostic value of radioimmunoassay for parathyroid in human serum. Acta Enocrinol. 1975; 78: 493
  • Freaney R., Ryan E., Muldowney F. P. Differentiation of hypercalcemia due to malignancy from primary hyperparathyroidism: the value of parathyroid hormone and plasma bicarbonate measurements. Ir. J. Med. Sci. 1981; 150: 6
  • Heath D. A., Aurbach C. D. Ectopic production of parathyroid hormone: a prototype of a non-endocrine hormone synthesis. Endocrinology and Diabetes, L. J. Kryston, R. A. Shaw. Grune & Stratton, New York 1975; 215
  • Bockman R. S. Hypercalcemia in malignancy. Clin. Endocrinol. Metab. 1980; 9: 317, (Part 2)
  • Benson R. C., Jr., Riggs B. L., Pickard B. M., Arnaud C. D. Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease. Am. J. Med. 1974; 56: 821
  • Stewart A., Horst R., Deftos L., Cadman E., et al. A non-parathyroid renotropic factor in humoral hypercalcemia of malignancy. Clin. Res. 1979; 27: 377, (Abstr.)
  • Sherwood L. M. The multiple causes of hypercalcemia in malignant disease. N. Engl. J. Med. 1980; 303: 1412
  • Ogburn P. L., Black B. M. Primary hyperparathyroidism and papillary carcinoma of the thyroid. Report of four cases. Proc. Staff. Meet., Mayo Clin. 1956; 31: 295
  • Rose G. A. The radiological diagnosis of osteoporosis. Clin, Radiol. 1964; 15: 75
  • Hellstrom J. Explorative surgery for suspected hyperparathyroidism. Acta Chir. Scand. 1962; 123: 371
  • Massaro D., Owen J., Jr. Persistent hypercalcemia associated with bronchogenic carcinoma and primary chief cell hyperplasia of the parathyroids. Am. Rev. Respir. Dis. 1962; 85: 727
  • Dent C. E., Watson L. Hyperparathyroidism and Cancer. Br. Med. J. 1964; 2: 218
  • Hellstrom J., Ivemark B. I. Hyperparathyroidism. Clinical and structural findings in 138 cases. Acta. Chir. Scand., (Suppl) 1962; 294: 1
  • Pyrah L. N., Hodgkinson A., Anderson C. K. Primary hyperparathyroidism—a critical review. Br. J. Surg. 1966; 53: 245
  • Kaplan L., Katz A. D., Ben-Isaac C., et al. Malignant neoplasms and parathyroid adenoma. Cancer 1971; 28: 401
  • Johanssen H., Werner I. Dysproteinaemia, malignancy and hyperparathyroidism. Ann. Intern. Med. 1975; 83: 121
  • Drezner M. K., Lebovitz H. E. Primary hyperparathyroidism in paraneoplastic hypercalcemia. Lancet 1978; 1: 1004
  • Aurbach G. D., Mallette L. E., Patten B. M., et al. Hyperparathyroidism: recent studies. Ann. Intern. Med. 1973; 79: 566
  • Samaan N. A., Hickey R. C., Hill C. S., Jr., Medellin H. 56th Annu. Meet. Endocrine Soc. (Abstract). 1974; A-298
  • Steiner A. L., Goodman A. D., Powers S. R. Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease. Multiple endocrine neoplasia type 2. Medicine (Baltimore) 1968; 47: 371
  • Brereton H. D., Haluschka P. B., Alexander R. W., Mason D. M., Keiser H. R., De Vita V. T., Jr. Indomethacin-responsive hypercalemia in the patient with renal-cell adenocarcinoma. N. Engl. J. Med. 1974; 291: 83
  • Benvenisti D., Goldberg H. Prostaglandins, indomethacin and hypercalcemia in neoplastic disease. N. Engl. J. Med. 1975; 292: 1189
  • Robertson P. R. Prostaglandins and hypercalcemia of cancer. Med. Clin. North Am. 1981; 65: 845
  • Seyberth H. W., Raisz L. G., Oates J. A. Prostaglandins and hypercalcemic states. Ann. Rev. Med. 1978; 29: 23
  • Mundy G. R., Raisz L. G., Cooper R. A., Schecter G. P., Salmon S. E. Evidence of the secretion of an osteoclast stimulating factor in myeloma. N. Engl. J. Med. 1974; 291: 1074
  • Roberts W. C., Waller B. F. Effect of chronic hypercalcemia on the heart. Am. J. Med. 1981; 71: 371
  • Alfrey A. C., Jenkins D., Groth C. G., Schorr W. S., Gecelter L., Ogden D. A. Resolution of hyperparathyroidism, renal osteodystrophy and metastatic calcification after renal homotransplantation. N. Engl. J. Med. 1968; 27: 1349
  • Kleerekoper M., Ibels L. S., Ingham J. P., McCarthy S. W., Mahony J. F., Stewart J. H., Posen S. Hyperparathyroidism after renal transplantation. Br. Med. J. 1975; 3: 680
  • Adams P. H., Jowsey J., Kelly P. J., Riggs L., Kinney V. R., Jones J. D. Effects of hyperthyroidism on bone and mineral metabolism in man. Q. J. Med. 1967; 36: 1
  • Parfitt A. M., Dent C. E. Hyperthyroidism and hypercalcemia. Q. J. Med. 1970; 39: 171
  • Farnsworth A. E., Dobyns B. M. Hypercalcemia and thyrotoxicosis. Med. J. Aust. 1974; 2: 782
  • Jones M. K., Papapopulos S. E. Control of hypercalcemia in thyrotoxicosis. Postgrad. Med J. 1979; 55: 891
  • Lowe C. E., Bird E. D., Thomas W. C. Hypercalcemia in myxoedema. J. Clin. Endocrinol. Metab. 1962; 22: 261
  • Lemberg B. A., Tikkenen M. G. Hypercalcemia due to dihydrotachysterol treatment in patients with hypothyroidism after thyroidectomy. Br. Med. J. 1981; 283: 461
  • Stote R. M., Smith L. H., Wilson D. M., Duke W. J., Goldsmith R. S., Arnaud C. D. Hydrochlorothiazide effects on serum calcium and immunoreactive parathyroid hormone concentration. Studies in normal subjects. Ann. Intern. Med. 1972; 77: 587
  • Christiansen C., Baastrup P. C., Transbol I. Lithium induced primary hyperparathyroidism. Calcified Tissue Res. Suppl. 1977; 22: 341
  • Koppel M. H., Massry S. G., Shinaberger J. H., Hartenbower D. L., Coburn J. W. Thiazide induced rise in serum calcium and magnesium in patients on maintenance dialysis. Ann. Intern. Med. 1970; 72: 895
  • Sode J., Sabol J. J., Meloni C. R., Canaary J. J. Thiazide challenge in primary hyperparathyroidism. Clin. Res. 1969; 17: 550
  • Belchetz P. E., Cohen R. D., O'Riordan J. L. H., Tomlinson S. Factitious hypercalcemia. Br. Med. J. 1976; 1: 690
  • Frame B., Jackson G. M., Kleerkoper M., Rao D. S., DeLorenzo A. J. D., Garcia M. Acute severe hypercalcemia a la Munchausen. Am. J. Med. 1981; 70: 316
  • Christensson T. A. T. Lithium hypercalcemia and hyperparathyroidism. Lancet 1976; 2: 144
  • Christiansen C., Baastrup P. C., Transbol I. Lithium hypercalcemia, hypermagnesemia and hyperparathyroidism. Lancet 1976; 2: 969
  • Marx S. J., Spiegel A. M., Levine M. A., Rizzoli R. E., Lasher R. D., Santora A. C., Downs R. W., Aurbach G. D. Familial hypocalciuric hypercalcemia. N. Engl. J. Med. 1982; 307: 416
  • Patterson C. R., Gunn A. Familial benign hypercalcemia. Lancet 1981; 2: 61
  • Davies M., Klimiuk P. S., Adams P. H., Lumb G. A., Large D. M., Anderson D. C. Familial hypocalcuric hypercalcemia and acute pancreatitis. Br. Med. J. 1981; 282: 1023
  • Burnett C. H., Commons R. R., Albright F., Howard J. E. Hypercalcemia without hypercalcuria, or hypophosphataemia, calcinosis, and renal insufficiency. N. Engl. J. Med. 1949; 240: 787
  • Wenger J., Kirsner J. B., Palmer W. L. The milk alkali syndrome Hypercalcemia alkalosis and azotaemia following calcium carbonate and milk therapy of peptic ulcer. Gastroenterology 1957; 33: 745
  • Papapoulos S. E., Clemens T. L., Fraher L. J., Luin I. G., Sandler L. M., O'Riordan J. L. H. 1–25 dihydroxycholecalciferol in the pathogenesis of the hypercalcemia of sarcoidosis. Lancet 1979; 1: 627
  • Bell W. H., Stern P. H., Pantzer E., Sinha T. K., DeLuca H. F. Evidence that increased circulating 1,25-dihydroxy vitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J. Clin. Invest. 1979; 64: 218
  • Parfitt A. M., Frame B. Corticosteroid-responsive hypercalcemia with elevated serum 1 alpha 25 dihydroxyvitamin D. Ann. Intern. Med. 1980; 93: 440
  • MacGregor G. A. 1–25 dihydroxycholecalciferol in pathogenesis of hypercalcemic sarcoidosis. Lancet 1979; 1: 1041
  • Schweitzer V. G., Thompson N. W., Clark K. A., Nishiyama R. H., Bigos S. T. Sarcoidosis hypercalcemia and primary hyperparathyroidism. Am, J. Surg. 1981; 142: 499
  • Albright F. Case records of Massachusetts General Hospital Case 27461. N. Engl. J. Med. 1941; 225: 789
  • Lawrence G. D., Loeffler R. G., Martin L. G., Connor T. B. Immobilization hypercalcemia. Some aspects of diagnosis and treatment. J. Bone J. Surg. 1973; 55A: 87
  • Reifenstein E. C., Albright F. Paget's disease pathology. Physiology and the importance of complications arising from fracture and treatment. N. Engl. J. Med. 1944; 231: 343
  • Drivas G., Ward M., Kerr D. Immobilization hypercalcemia in patients on regular haemodialysis. Br. Med. J. 1975; 2: 468
  • Nordin B. E. C., Fraser R. Assessment of urinary phosphate excretion. Lancet 1960; 1: 947
  • Nordin B. E. C., Bulusu L. A modified index of phosphate excretion. Postgrad. Med. J. 1968; 44: 93
  • Patterson C. R. Metabolic Disorders of Bone, 1st ed. Blackwell Scientific, Guildford 1974; 53
  • Hall R., Anderson J., Smart J. A., Besser M. Fundamental Details of Clinical Endocrinology, 2nd ed. Pitman Medical Press, Bath 1974; 403
  • Wills M. R., McGowan G. K. Plasma chloride levels in hyperparathyroidism and other hypercalcemic states. Br. Med. J. 1964; 1: 1153
  • Wills M. R. Value of plasma chloride concentration and acid base status in the differential diagnosis of hyperparathyroidism from other causes of hypercalcemia. J. Clin. Pathol. 1971; 24: 219
  • Dent C. E., Watson L. The hydrocortisone test in primary and tertiary hyperparathyroidism. Lancet 1968; 2: 662
  • Dent C. E., Harper C. M. Plasma alkaline phosphatase in normal adults and in patients with hyperparathyroidism. Lancet 1962; 1: 559
  • Transbol I. B., Hornum I. B., Hahnemann S., Hasner E., Ohlenschlager H., Diemer H., Lockwood K. Tubular reabsorption of calcium in the differential diagnosis of hypercalcemia. Acta Med. Scand. 1970; 188: 505
  • Drach G. W., Stanton-King J., Jr. Estimating aberrant homeostasis: variance in serum calcium concentration as an aid in diagnosis of hyperparathyroidism. Clin. Chem. 1970; 16: 792
  • Broadus A. E., Horst R. L., Lang R., Littledike E. T., Rasmussen H. The importance if circulating 1–25 dihydroxy vitamin D in the pathogenesis of hypercalcuria and renal stone formation in primary hyperparathyroidism. N. Engl. J. Med. 1980; 302: 421
  • Heath H., III, Purnell D. C. Urinary cyclic 3′ 5′ adenosine monophosphate responses to exogenous and endogenous parathyroid hormone in familial benign hypercalcemia and primary hyperparathyroidism. J. Lab. Clin. Med. 1980; 96: 974
  • Marx S. J., Spiegel A. M., Sharp M. E., Brown E. M., Gardner D. G., Downes R. W., Jr., Attic M. F., Stock J. L. Adenosine 3′ 5′ monophosphate response to parathyroid hormone: familial hypocalcuric hypercalcemia versus typical primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 1980; 50: 546
  • Neelon F. A., Birch B. M., Drezner M., Lebovitz H. E. Urinary Cyclic adenosine monophosphate as an aid in the diagnosis of hyperparathyroidism. Lancet 1973; 1: 631
  • Drezner M. K., Neelon F. A., Curtis H. B., Lebovitz H. E. Renal cyclic adenosine monophosphate: an accurate index of parathyroid function. Metabolism. 1976; 25: 1103
  • Broadus A. E., Deftos L. J., Bartter F. C. Effects of the intravenous administration of calcium on nephrogenous cycle AMP. J. Clin. Endocrinol. Metab. 1978; 46: 477
  • Broadus A. E., Mahaffey J. E., Bartter F. C., Neer R. M. Nephrogenous cyclic adenosine monophosphate as a parathyroid function test. J. Clin. Invest. 1977; 60: 771
  • Torring O., Cavallin M., Low H., Werner S. Urinary cyclic AMP corrected for glomerular filtration rate in the differential diagnosis of hypercalcemia. Acta Med. Scand. 1982; 211: 401
  • Froeling P. G. A. M., Bijvoet O. L. M. Kidney mediated effects of parathyroid hormone on extracellular homeostasis of calcium, phosphate and acid base balance in man. Neth. Med. J. 1974; 17: 174
  • Boyd J. C., Lewis J. W., Slatopolsky E., Ladenson J. H. Parathyrin measured concurrently with free or total calcium in the differential diagnosis of hypercalcemia. Clin. Chem. 1981; 27: 574
  • Berson S. A., Yalow R. S., Aurbach G. D., Potts J. T., Jr. Immunoassay of bovine and human parathyroid hormone. Proc. Natl. Acad. Sci. U.S.A. 1963; 49: 613
  • Tashjian A. H., Levine L., Munson J. Immunochemical identification of parathyroid hormone in nonparathyroid neoplasia associated with hypercalcemia. J. Exp. Med. 1964; 119: 467
  • Roof B. S., Carpenter B., Fink D. J., Gordon G. S. Some thoughts on the nature of ectopic parathyroid hormones. Am. J. Med. 1971; 50: 686
  • Riggs B. L., Arnaud C. D., Reynolds J. C., Smith L. H. Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer. J. Clin. Invest. 1971; 50: 2079
  • Mayo Medical Laboratories. Communique 1979; 4(4)
  • Silverman R., Yalow R. S. Heterogeneity of parathyroid hormone. Clinical and physiological complications. J. Clin. Invest. 1973; 52: 1958
  • Arnaud C. D., Goldsmith R. S., Bordier P. J., et al. Influence of immunoheterogeneity of circulating parathyroid hormone on results of radioimmunoassays of serum in man. Am. J. Med. 1974; 56: 785
  • Cohn D. V., MacGregor R. R., Chu L. L. H., et al. Biosynthesis of proparathyroid hormone and parathyroid hormone. Chemistry, physiology and role of calcium in regulation. Am. J. Med. 1974; 56: 767
  • Kemper B. B., Habener J. F., Mulligan R. C., et al. Pre-proparathyroid hormone: a direct translation product of parathyroid messenger RNA. Proc. Natl. Acad. Sci. U.S.A. 1974; 71: 3731
  • Canterbury J. M., Bricker L. A., Levey G. S., et al. Metabolism of bovine parathyroid hormone. Immunological and biological characteristics of fragments generated by liver perfusion. J. Clin. Invest. 1975; 55: 1245
  • Hruska K. A., Kopelman R., Rutherford W. E., et al. Metabolism of immunoreactive parathyroid hormone in the dog. The role of the kidney and the effects of chronic renal disease. J. Clin. Invest. 1975; 56: 39
  • Canterbury J. M., Reiss E. Multiple immunoreactive molecular forms of parathyroid hormone in human serum. Proc. Soc. Exp. Biol. Med. 1972; 140: 1393
  • Canterbury J. M., Levey G. S., Reiss E. Activation of renal cortical adenylate cyclase by circulating immunoreactive parathyroid hormone fragments. J. Clin. Invest. 1973; 52: 524
  • Goltzman D. Parathyroid hormone and hyperparathyroidism: current concepts. Can. J. Surg. 1978; 21: 285
  • Juan D. Differential diagnosis of hypercalcemia, A mechanistic approach. Postgrad. Med. 1979; 66(4)72
  • Powell D., Singer F. R., Murray T. M., et al. Non-parathyroid humoral hypercalcemia in patients with neoplastic disease. N. Engl. J. Med. 1973; 289: 176
  • Nissenson R. A., Arnaud C. D. Properties of the parathyroid hormone receptor-adenylate cyclase system in chicken renal plasma membranes. J. Biol. Chem. 1979; 254: 1469
  • Wong E. T., Freier E. F. The differential diagnosis of hypercalcemia. An algorithm for more effective use of laboratory tests. JAMA 1982; 287: 75
  • Bayliss P. H., Milles J. J., Wilkinson R., Health D. A. Vasopressin function in hypercalcemia. Clin. Endocrinol. 1981; 15: 343
  • Worlsman J., Frank S. The Q-T interval in clinical hypercalcemia. Clin. Cardio. 1981; 4: 87
  • Wills M. R. Laboratory tests in the differentiation of hyperparathyroidism from other causes of hypercalcemia. Ann. Clin. Biochem. 1970; 7: 136
  • Heinemann H. O. Metabolic alkalosis in patients with hypercalcemia. Metab. Clin. Exp. 1965; 14: 1137
  • Broulik P. D., Pacovsky V. The chloride phosphate ratio as the screening test for primary hyperparathyroidism. Horm. Metab. Res. 1974; 11: 577
  • Palmer F. J., Nelson J. C., Bacchus H. The chloride phosphate ratio in hypercalcemia. Ann. Intern. Med. 1974; 80: 200
  • Drago J. R., Ronher T. J., Sanford E. J. Diagnosis of hyperparathyroidism. Urology 1976; 7: 4
  • Reynolds L. R., Flueck J. A. Evaluation of the hypercalcemic patient. Am. Fam. Phys. 1981; 23: 105
  • Amenta J. S., Harkins M. L. The use of discriminant functions in laboratory medicine. Am. J. Clin. Pathol. 1971; 55: 330
  • Fraser P., Healey M., Rose M., Watson L. Discriminant functions in differential diagnosis of hypercalcemia. Lancet 1971; 1: 1314
  • Fraser P., Healey M., Watson L. Further experience with discriminant functions in the differential diagnosis of hypercalcemia. Postgrad. Med. J. 1976; 52: 254
  • Fraser P., Watson L., Moxham J. Hydrocortisone suppression test and discriminant analysis in differential diagnosis of hypercalcemia. Lancet 1980; 1: 1320
  • LoCascio V., Cominacini L., Adami S., Galvanini G., Bainchi I., Zanini R., Scruro L. A. Primary hyperparathyroidism. Diagnostic value of a multivariate statistical analysis. La. Ricerca. Clin. Lab. 1976; 6: 267
  • LoCascio V., Vallaperta P., Adami S., Cominacici L., Galvanini G., Bianchi I., Ferrari M., Scuro L. A. Discriminant analysis in the differential diagnosis of hypercalcemia. Clin. Endocrinol. 1978; 8: 349
  • Transbol I., Schonau-Jorgensen F., Hornum I., Keiding N. Hypercalcemia discrimination index. A multivariate analysis of parathyroid function in 107 hypercalcemic patients. Acta Endocrinol. 1977; 86: 768
  • Grero P. S., Hodkinson H. M. Hypercalcemia in elderly hospital in-patients: value of discriminant analysis in differential diagnosis. Age Ageing 1977; 6: 19
  • Fisken R. A., Heath D. A., Somers S., Bold A. M. Hypercalcemia in hospital patients. Lancet 1981; 1: 202
  • Holland M. R., Jacobs A. G. On the transportability of linear discriminant functions. Ann. Clin. Biochem. 1982; 19: 47
  • Elsworth R., Howard J. E. Studies in the physiology of the parathyroid glands. Bull. Johns Hopkins Hosp. 1934; 55: 296
  • Goldsmith R. S., Fourland M. Rapid calcium infusion test for hyperparathyroidism. Arch. Intern. Med. 1964; 113: 550
  • Broadus A. E., Horst E. L., Littledyke E. Y., Mahaffey J. E., Rasmussen H. Primary hyperparathyroidism with intermittent hypercalcemia, serial observations and simple diagnosis by means of an oral calcium tolerance test. Clin. Endocrinol. 1980; 12: 225
  • Nilsson O., Almqvist Est, Carlberg B. E. Salmon calcitonin in the acute treatment of moderate and severe hypercalcemia in man. Acta Med. Scand. 1978; 204: 249
  • Anderson J., Dent C. E., Harper C., Philpot G. R. Effect of cortisone on calcium metabolism in sarcoidosis with hypercalcemia. Possibly antagonistic actions of cortisone and Vitamin D. Lancet 1954; 2: 720

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