Biochemical Markers in Sarcoidosis

References

• James D. G., Turiaf J., Hosoda Y., Jones Williams W., Israel H. L., Douglas A. C., Siltzbach L. E. Description of sarcoidosis: report of the subcommittee on classification and definition. Ann. N.Y. Acad. Sci. 1976; 278: 742
   PubMed Web of Science ®Google Scholar
• Harrell G. T., Fischer S. Blood chemical studies in Boeck's sarcoid, with particular reference to protein, calcium and phosphatase values. J. Clin. Invest. 1939; 18: 687
   PubMedGoogle Scholar
• McCort J. J., Wood R. H., Hamilton J. B., Ehrlich D. E. Sarcoidosis: a clinical and roentgenologic study of 28 cases. Arch, Intern, Med. 1947; 80: 293
   Google Scholar
• Cummings M. M., Jr. Epidemiologic and clinical observations in sarcoidosis. Ann. Intern. Med. 1959; 50: 879
   PubMed Web of Science ®Google Scholar
• Mayock R. L., Bertrand P., Morrison C. E., Scott J. H. Manifestations of sarcoidosis. Analysis of 145 patients, with review of nine series selected from the literature. Am. J. Med. 1963; 35: 67
   PubMed Web of Science ®Google Scholar
• Putkonen T., Hannuksela M., Halme H. Calcium and phosphorus metabolism in sarcoidosis. Acta Med. Scand. 1965; 177: 327
   PubMedGoogle Scholar
• Scadding J. G. Calcium metabolism in sarcoidosis: hypercalcaemia and hypercalcaemic nephropathy. Sarcoidosis. Eyre & Spottiswoode, London 1967; 340
   Google Scholar
• James D. G. Diagnosis and treatment of sarcoidosis. Br. Med. J. 1956; II: 900
   Google Scholar
• James D. G. Course and prognosis of sarcoidosis: London. Am. Rev. Respir. Dis. 1961; 84(5, 2)66
   PubMedGoogle Scholar
• Selroos O. The frequency, clinical picture and prognosis of pulmonary sarcoidosis in Finland. Acta Med. Scand. 1969, Suppl. 503
   PubMedGoogle Scholar
• Elo J. J. Sarkoidoosi. Kliininen tutkimus varsinais-Suomen tuberkuloosipiirissä 1965–1977. (Sarcoidosis. A Clinical Investigation in Southeast Finland in 1965 to 1977). Ph.D. thesis, University of Turku, Finland 1983
   Google Scholar
• Koivunen E. Hematologiset löydöket sarkoidoosissa (Hematological Findings in Sarcoidosis). Ph.D. thesis, Tampere University, Tampere, Finland 1985
   Google Scholar
• James D. G., Neville E., Siltzbach L. E., Turiaf J., Battesti J. P., Sharma O. P., Hosoda Y., Mikami R., Odaka M., Villar T. G., Djuric B., Douglas A. C, Middleton W., Karlish A., Blasi A., Olivieri D., Press P. A worldwide review of sarcoidosis. Ann. N.Y. Acad. Sci. 1976; 278: 321
   PubMed Web of Science ®Google Scholar
• Goldstein R. A., Israel H. L., Becker K. L., Moore C. F. The infrequency of hypercalcaemia in sarcoidosis. Am. J. Med. 1971; 51: 21
   PubMed Web of Science ®Google Scholar
• Sharma O., Trowell J., Cohen N., Bird R., James D. G. Abnormal calcium metabolism in sarcoidosis. LA SARCOIDOSE, J. Turiaf, J. Chabot. Masson, Paris 1967; 627
   Google Scholar
• Lebacq E., Verhaegen H., Desmet V. Renal involvement in sarcoidosis. Postgrad. Med. J. 1970; 46: 526
   PubMedGoogle Scholar
• Henneman P. H., Carroll E. L., Dempsey E. F. Mechanism responsible for hypercalciuria in sarcoid. J. Clin. Invest. 1954; 33: 941
   Google Scholar
• Anderson J., Dent C. E., Harper C, Philpot G. R. Effect of cortisone on calcium metabolism in sarcoidosis with hypercalcaemia; possible antagonistic actions of cortisone and vitamin D. Lancet 1954; 2: 720
   Google Scholar
• Papapoulos S. E., Fraher L. J., Sandler L. M., Clemens T. L., Lewin I. G., O'Riordan J. L. H. 1,25-dihydroxy-choIecalciferol in the pathogenesis of the hypercalcaemia of sarcoidosis. Lancet 1979; 1: 627
   PubMed Web of Science ®Google Scholar
• Bell N. H., Stern P. H., Pantzer E., Sinha T. K., DeLuca H. F. Evidence that increased lα,25-dihydroxyvitamin D, is the probable cause for abnormal calcium metabolism in sarcoidosis. J. Clin. Invest. 1979; 64: 218
   PubMed Web of Science ®Google Scholar
• Chesney R. W., Hamstra A. J., DeLuca H. F., Horowitz S., Gilbert E. F., Hong R., Borcherding W. Elevated serum 1,25-dihydroxyvitamin D concentrations in the hypercalcemia of sarcoidosis: correction by glucocorticoid therapy. J. Pediatr. 1981; 98: 919
   PubMedGoogle Scholar
• Koide Y., Kugai N., Kimura S., Fujita T., Yamashita N., Hiramoto T., Sukegawa J., Ogata E., Yamashita K. Increased 1,25-dihydroxycholecalciferol as a cause of abnormal calcium metabolism in sarcoidosis. J. Clin. Endocrinol. Metab. 1981; 52: 494
   PubMedGoogle Scholar
• Barbour G. L., Coburn J. W., Slatopolsky E., Norman A. W., Horst R. L. Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxyvitamin D. N. Engl. J. Med. 1981; 305: 440
   PubMed Web of Science ®Google Scholar
• Meyrier A., Valeyre D., Boullion R., Paillard F., Battesti J-P, Georges R. Resorptive versus absorptive hypercalciuria in sarcoidosis: correlations with 25-hydroxy vitamin D3 and 1,25-dihydroxyvitamin Di and parameters of disease activity. Q. J. Med. 1985; 54: 269
   PubMedGoogle Scholar
• Adams J. S., Sharma O. P., Gacad M. A., Singer F. R. Metabolism of 25-hydroxyvitamin D3, by cultured pulmonary alveolar macrophages in sarcoidosis. J. Clin. Invest. 1983; 72: 1856
   PubMed Web of Science ®Google Scholar
• Adams J. S., Singer F. R., Gacad M. A., Sharma O. P., Hayes M. J., Vouros P., Holick M. F. Isolation and structural identification of 1,25-dihydroxyvitamin D3, produced by cultured alveolar macrophages in sarcoidosis. J. Clin. Endocrinol. Metab. 1985; 60: 960
   PubMed Web of Science ®Google Scholar
• Mason R. S., Frankel T. H., Chan Y-L., Lissner D., Posen S. Vitamin D conversion by sarcoid lymph node homogenate. Ann. Intern. Med. 1984; 100: 59
   PubMed Web of Science ®Google Scholar
• Sandler L. M., Winearls C. G., Fraher J. L., Clemens T. L., Smith R., O'Riordan J. L. H. Studies of the hypercalcaemia of sarcoidosis: effect of steroids and exogenous vitamin D3, on the circulating concentrations of 1,25-dihydroxy vitamin D3. Q. J. Med. 1984; 53: 165
   PubMedGoogle Scholar
• Skeggs L. T., Jr., Marsh W. H., Kahn J. R., Shumway N. P. The existence of two forms of hypertensin. J. Exp. Med. 1954; 99: 275
   PubMed Web of Science ®Google Scholar
• Skeggs L. T., Jr., Kahn J. R., Shumway N. P. The preparation and function of the hypertensin-converting enzyme. J. Exp. Med. 1956; 103: 295
   PubMed Web of Science ®Google Scholar
• Lentz K. E., Skeggs L. T., Jr., Woods K. R., Kahn J. R., Shumway N. P. The amino acid composition of hypertensin II and its biochemical relationship to hypertensin I. J. Exp. Med. 1956; 104: 183
   PubMed Web of Science ®Google Scholar
• Ng K. K. F., Vane J. R. Conversion of angiotensin I to angiotensin II. Nature (London) 1967; 216: 762
   PubMed Web of Science ®Google Scholar
• Ferreira S. H., Vane J. R. The disappearance of bradykinin and elediosin in the circulation and vascular beds of the cat. Br. J. Pharmacol. 1967; 30: 417
   PubMed Web of Science ®Google Scholar
• Ng K. K. F., Vane J. R. Fate of angiotensin 1 in the circulation. Nature (London) 1968; 218: 144
   PubMed Web of Science ®Google Scholar
• Lanzillo J. J., Fanburg B. L. Angiotensin I converting enzyme from human plasma. Biochemistry 1977; 16: 5491
   PubMed Web of Science ®Google Scholar
• Grönhagen-Riska C., Fyhrqvist F. Purification of human lung angiotensin-converting enzyme. Scand. J. Clin. Lab. Invest. 1980; 40: 711
   PubMed Web of Science ®Google Scholar
• Softer R. L., Sonnerblick E. H. Physiologic, biochemical and immunologic aspects of angiotensin-converting enzyme. Prog. Cardiovasc. Di.s. 1978; 21: 167
   PubMedGoogle Scholar
• Caldwell P. R. B., Seegal B. C, Hsu K. C, Das M., Soffer R. L. Angiotensin-converting enzyme; vascular endothelial localization. Science 1976; 191: 1050
   PubMed Web of Science ®Google Scholar
• Ryan U. S., Ryan J. W., Whitaker C, Chiu A. Localization of angiotensin converting enzyme (kininase II). II. Immunochemistry and immunofluorescence. Tissue Cell 1976; 8: 125
   PubMed Web of Science ®Google Scholar
• Cushman D. W., Cheung H. S. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 1971; 20: 1637
   PubMed Web of Science ®Google Scholar
• Lieberman J. Elevation of serum angiotensin-converting enzyme (ACE) level in sarcoidosis. Am. J. Med. 1975; 59: 365
   PubMed Web of Science ®Google Scholar
• Chiknas S. G. A liquid chromatography assisted assay for angiotensin converting enzyme in the serum. Clin. Chem. 1979; 25: 1259
   PubMed Web of Science ®Google Scholar
• Friedland J., Silverstein E. A sensitive fluorimetric assay for serum angiotensin converting enzyme. Am. J. Clin. Pathol. 1976; 66: 416
   PubMed Web of Science ®Google Scholar
• Friedland J., Silverstein E. Sensitive fluorimetric assay for serum angiotensin converting enzyme with the natural substrate angiotensin I. Am. J. Clin. Pathol. 1977; 67: 225
   Google Scholar
• Dorer F. E., Skeggs I. T., Khan J. R., Lentz K. E., Levine M. Angiotensin converting enzyme. Method of assay and partial purification. Anal. Biochem. 1970; 33: 102
   PubMedGoogle Scholar
• Kasahara Y., Ashihara Y. Colorimetry of angiotensin converting enzyme activity in serum. Clin. Chem. 1981; 27: 1922
   PubMed Web of Science ®Google Scholar
• Rohrbach M. C. (Glycine-l-l4C)hippuryl-l-histidyl-l-leucine: a substrate for the radiochemical assay of angiotensin converting enzyme. Anal. Biochem. 1978; 84: 272
   PubMed Web of Science ®Google Scholar
• Ryan J. W., Chung A., Amnions C, Carlton M. L. A simple radioassay for angiotensin converting enzyme. Biochem. J. 1977; 167: 4
   Google Scholar
• Römer F. K. Comparison of two methods for measurement of serum angiotensin-converting enzyme in sarcoidosis. Scand. J. Clin. Lab. Invest. 1982; 42: 197
   PubMed Web of Science ®Google Scholar
• Fyhrqvist F., Tikkanen I., Grönhagen-Riska C., Hortlirig L., Hichens M. Inhibitor binding assay for angiotensin-converting enzyme. Clin. Chem. 1984; 30: 696
   PubMedGoogle Scholar
• Pertschuk L. P., Silverstein E., Rosen Y., Friedland J., Brigati D. J. Immunohistochemical method for the diagnosis of sarcoidosis. Am. J. Clin. Pathol. 1979; 72: 648
   Google Scholar
• Pertschuk L. P., Silverstein E., Friedland J. Immunohistologic diagnosis of sarcoidosis. Detection of angiotensin-converting enzyme in sarcoid granulomas. Am. J. Clin. Pathol. 1981; 75: 350
   PubMed Web of Science ®Google Scholar
• Takada Y., Hiwada K., Akutsu H., Hashimoto A., Kokubu T. The immunocytochemical detection of angiotensin-converting enzyme in alveolar macrophages from patients with sarcoidosis. Lung 1984; 162: 317
   PubMed Web of Science ®Google Scholar
• Lanzillo J. J., Fanburg B. L. Angiotensin I converting enzyme from human plasma. Biochemistry 1977; 16: 5491
   PubMed Web of Science ®Google Scholar
• Klauser R. J., Robinson C. J. G., Erdös E. G. Inhibition of kininase II (angiotensin I converting enzyme) by human serum albumin and its fragments. Adv. Exp. Med. Biol. 1978; 120 B: 477
   Google Scholar
• Römer F. K., Jacobsen F. The influence of prednisone on angiotensin-converting enzyme activity in patients with and without sarcoidosis. Scand. J. Clin. Lab. Invest. 1982; 43: 377
   Google Scholar
• Römer F. K. Clinical and biochemical aspects of sarcoidosis—with special reference to angiotensin-converting enzyme (ACE). Acta Med. Scand. 1983, Suppl. 690
   Google Scholar
• Turton C. G. W., Grundy E., Firth G., Mitchell D., Rigden B. G., Turner-Warwick M. Value of measuring serum angiotensin I converting enzyme and serum lysozyme in the management of sarcoidosis. Thorax 1979; 34: 57
   PubMed Web of Science ®Google Scholar
• Grönhagen-Riska C., Selroos O., Niemistö M. Angiotensin converting enzyme. V. Serum levels as monitors of disease activity in corticosteroid-treated sarcoidosis. Eur. J. Respir. Dis. 1980; 61: 113
   PubMedGoogle Scholar
• Grönhagen-Riska C. Angiotensin-converting enzyme. I. Activity and correlation with serum lysozyme in sarcoidosis, other chest or lymph node diseases and healthy persons. Scand. J. Respir. Dis. 1979; 60: 83
   PubMedGoogle Scholar
• Lieberman J., Nosal A., Schlessner L. A., Sastre-Foken A. Serum angiotensin-converting enzyme for diagnosis and therapeutic evaluation of sarcoidosis. Am. Rev. Respir. Dis. 1979; 120: 329
   PubMed Web of Science ®Google Scholar
• Proc. 8th Int. Conf. Sarcoidosis Other Granulomatous Disease. 1978, W. Jones Williams, D. H. Davis. Alpha Omega, Cardiff, Wales 1980; 239, Session VI, Angiotensin converting enzyme (chairmen: James, D. G. and Lieberman, J.)
   Google Scholar
• Proc. 9th Int. Conf. on Sarcoidosis Other Granulomatous Disorders. 1981, J. Chrétien, J. Marsac, J. C Saltiel. Pergamon Press, Paris 1983; 319, Session V, Assessment of the activity and extent of the granulomatous process (chairpersons: Silverstein, E., Mitchell, D. N., Izumi, T., and Voisin, C)
   Google Scholar
• Sarcoidosis, Proc. Int. Symp. Sarcoidosis. November 14–16, 1979, R. Mikami, Y. Hosoda. University of Tokyo Press, Japan 1981; 173, Session III, Angiotensin converting enzyme in sarcoidosis, (chairman: Mikami, R.)
   Google Scholar
• Grönhagen-Riska C. Angiotensin Converting Enzyme and Sarcoidosis. Ph.D. thesis, University of Helsinki, Helsinki, Finland 1980
   Google Scholar
• Grönhagen-Riska C., Selroos O., Wäger G., Fyhrqvist F. Angiotensin-converting enzyme. II. Serum activity in early and newly diagnosed sarcoidosis. Scand. J. Respir. Dis. 1979; 60: 94
   PubMedGoogle Scholar
• Römer F. K. Angiotensin-converting enzyme in sarcoidosis. Acta Med. Scand. 1979; 206: 27
   PubMed Web of Science ®Google Scholar
• Rohrbach M. S., DeRemee R. A. Serum angiotensin converting enzyme activity in sarcoidosis as measured by a simple radiochemical assay. Am. Rev. Respir. Dis. 1979; 119: 761
   PubMed Web of Science ®Google Scholar
• Mayr K., Aspöck G., Mayer K. H., Waibel K., Leitner L. Das Angiotensin-Converting-Enzym bei Lungenerkrankungen. Wien Med. Wochenschr. 1985; 135: 109
   PubMedGoogle Scholar
• Selroos O., Grönhagen-Riska C. Angiotensin converting enzyme. III. Changes in serum level as an indicator of disease activity in untreated sarcoidosis. Scand. J. Respir. Dis. 1979; 60: 328
   PubMedGoogle Scholar
• Simonowitz L. J., Solliday W., Celic L., Cugell D. Serial measurement of angiotensin converting enzyme and diffusing capacity in sarcoidosis. Am. Rev. Respir. Dis. 1977; 115(2)164
   Google Scholar
• Weaver L. J., Solliday N. H., Celic L., Cugell D. Serial observations of angiotensin-converting enzyme and pulmonary function in sarcoidosis. Arch. Intern. Med. 1981; 141: 931
   PubMedGoogle Scholar
• DeRemee R. A., Rohrbach M. S. Serum angiotensin-converting enzyme activity in evaluating the clinical course of sarcoidosis. Ann. Intern. Med. 1980; 92: 361
   PubMed Web of Science ®Google Scholar
• Sehrt I., Christ R. Serumangiotensinkonvertase-aktivität und klinische Verlauf der Sarkoidose. Z. Erkr. Atmungsorgane 1984; 163: 175
   PubMedGoogle Scholar
• Erskine K. J., Taylor K. J., Agnew R. A. L. Serial estimation of serum angiotensin converting enzyme activity during and after pregnancy in a woman with sarcoidosis. Br. Med. J. 1985; 290: 269
   PubMedGoogle Scholar
• Gupta R. G., Oparil S., Szidon J. P., Daise M. Clinical significance of serum angiotensin-converting enzyme levels in sarcoidosis. J. Lab. Clin. Med. 1979; 93: 940
   PubMed Web of Science ®Google Scholar
• Lufkin E. G., DeRemee R. A., Rohrbach M. S. The predictive value of serum angiotensin-converting enzyme activity in the differential diagnosis of hypercalcemia. Mayo Clin. Proc 1983; 58: 447
   PubMed Web of Science ®Google Scholar
• DeRemee R. A., Lufkin E. G., Rohrbach M. S. Serum angiotensin-converting enzyme activity. Its use in the evaluation and management of hypercalcemia associated with sarcoidosis. Arch. Intern. Med. 1985; 145: 677
   PubMedGoogle Scholar
• Rühle K. H., Burmeister P., Henne R., Costabel U., Matthys H. Initiale Beeinflussung der ACE-Spiegel durch unterschiedliche Kortikoiddosen bei Patienten mit Sarkoidose II. Prax. Klin. Pneumol. 1985; 39: 15
   PubMedGoogle Scholar
• Selroos O. Use of Budesonide in the treatment of pulmonary sarcoidosis. Ann. N.Y. Acad. Sci. 1986; 465: 713
   PubMed Web of Science ®Google Scholar
• Grönhagen-Riska C., Selroos O. Angiotensin converting enzyme. IV. Changes in serum activity and in lysozyme concentrations as indicators of the course of untreated sarcoidosis. Scand. J. Resp. Dis. 1979; 60: 337
   PubMedGoogle Scholar
• Römer F. K. The level of angiotensin-converting enzyme as indicator of 2-year prognosis in untreated pulmonary sarcoidosis without erythema nodosum. Acta Med. Scand. 1982; 211: 293
   PubMedGoogle Scholar
• Crystal R. G., Gadek J. E., Ferrans V. J., Fulmer J. D., Line B. R., Hunninghake G. W. Interstitial lung disease. Current concepts of pathogenesis, staging and therapy. Am. J. Med. 1981; 70: 542
   PubMed Web of Science ®Google Scholar
• Hunninghake G. W., Fulmer J. D., Young R. G., Jr., Gadek J. E., Crystal R. G. Localization of the immune response in sarcoidosis. Am. Rev. Respir. Dis. 1979; 120: 49
   PubMedGoogle Scholar
• Crystal R. G., Roberts W. C, Hunninghake G. W., Gadek J. E., Fulmer J. D., Line B. R. Pulmonary sarcoidosis: a disease characterized and perpetuated by activated lung-T-lymphocytes. Ann. Intern. Med. 1981; 94: 73
   PubMed Web of Science ®Google Scholar
• Hunninghake G. W., Crystal R. G. Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N. Engl. J. Med. 1981; 305: 429
   PubMed Web of Science ®Google Scholar
• Costabel U., Bross K. J., Matthys H. Pulmonary sarcoidosis: assessment of disease activity by lung lymphocyte subpopulations. Klin. Wochenschr. 1983; 61: 349
   PubMedGoogle Scholar
• Proc. 9th Int. Conf. Sarcoidosis Granulomatous Disorders. 1981, J. Chrétien, J. Marsac, J. C Saltiel. Pergamon Press, Paris 1983; 414, Session V, Assessment of the activity and extent of the granulomatous process, IV. Broncho-alveolar lavage (chairpersons: Girard, J. P., Turner-Warwick, M., Scadding, J. R., and Robalo Cordiero, A. J.)
   Google Scholar
• Radermecker M., Gustin M., Saint-Remy P. Lack of correlation between serum angiotensin-converting enzyme and bronchoalveolar lymphocytosis in lung sarcoidosis. Eur. J. Respir. Dis. 1984; 65: 189
   PubMedGoogle Scholar
• Baughman R. P., Fernandez M., Bosher C. H., Mantil J., Hurtubise P. Comparison of gallium-67 scanning, bronchoalveolar lavage, and serum angiotensin-converting enzyme levels in pulmonary sarcoidosis. Am. Rev. Respir. Dis. 1984; 129: 676
   PubMed Web of Science ®Google Scholar
• Cohen R. D., Bunting P. S., Meindok H. O., Chamberlain D. W., Rebuck A. S. Does serum angiotensin converting enzyme reflect intensity of alveolitis in sarcoidosis?. Thorax 1985; 40: 497
   PubMed Web of Science ®Google Scholar
• Rossman M. D., Dauber J. H., Cardillo M. E., Daniele R. P. Pulmonary sarcoidosis: correlation of serum angiotensin-converting enzyme with blood and bronchoalveolar lymphocytes. Am. Rev. Respir. Dis. 1982; 125: 366
   PubMedGoogle Scholar
• Schoenberger C. I., Line B. R., Keogh B. A., Hunninghake G. W., Crystal R. G. Lung inflammation in sarcoidosis: comparison of serum angiotensin-converting enzyme levels with bronchoalveolar lavage and gallium-67 scanning assessment of the T lymphocyte alveolitis. Thorax 1982; 37: 19
   PubMedGoogle Scholar
• Lawrence E. C., Teague R. B., Gottlieb M. S., Jhingran S. G., Lieberman J. Serial changes in markers of disease activity with corticosteroid treatment of sarcoidosis. Am. J. Med. 1983; 74: 747
   PubMed Web of Science ®Google Scholar
• Hollinger W. M., Staton G. W., Jr., Fajman W. A., Gilman M. J., Pine J. R., Check I. J. Prediction of therapeutic response in steroid-treated pulmonary sarcoidosis. Am. Rev. Respir. Dis. 1985; 132: 65
   PubMed Web of Science ®Google Scholar
• Braude A. C., Chamberlain D. W., Rebuck A. S. Pulmonary disposition of gallium-67 in humans: concise communication. J. Nucl. Med. 1982; 23: 574
   PubMed Web of Science ®Google Scholar
• Nosal A., Schleissner L. A., Mishkin F. S., Lieberman J. Angiotensin-I-converting enzyme and gallium scan in noninvasive evaluation of sarcoidosis. Ann. Intern. Med. 1979; 90: 328
   PubMed Web of Science ®Google Scholar
• Alberts C, van der Schoot J. B., van Daatselaar J. J., Braat M. C. P., Roos C. M. 67Ga scintigraphy, serum lysozyme and angiotensin-converting enzyme in pulmonary sarcoidosis. Eur. J. Respir. Dis. 1983; 64: 38
   PubMedGoogle Scholar
• Klech H., Kohn H., Kummer F., Mostbeck A. Assessment of activity in sarcoidosis. Sensitivity and specificity of 67gallium scintigraphy, serum ACE levels, chest roentgenography, and blood lympyhocyte subpopulations. Chest 1982; 82: 732
   PubMed Web of Science ®Google Scholar
• Beaumont D., Herry J. Y., Sapene M., Bourguet P., Larzal J. J., Labarthe B. D. Gallium-67 in the evaluation of sarcoidosis: correlations with serum angiotensin-converting enzyme and broncho-alveolar lavage. Thorax 1982; 37: II
   Google Scholar
• Studdy R. P., James D. G. The specificity and sensitivity of serum angiotensin converting enzyme in sarcoidosis and other disease. Experience in twelve centres in six different countries. Sarcoidosis and Other Granulomatous Disorders, J. Chrètien, J. Marsac, J. C Saltiel. Pergamon Press, Paris 1983; 322
   Google Scholar
• Ainslie G. M., Benatar S. R. Serum angiotensin converting enzyme in sarcoidosis: sensitivity and specificity in diagnosis: correlations with disease activity, duration, extra-thoracic involvement, radiographic type and therapy. Q. J. Med. 1985; 55/218: 253
   Google Scholar
• Siafakas N. M., Dahabreh G., Papapaskali A., Gratziou C. Serum angiotensin-converting enzyme in patients with bronchogenic carcinoma before and after surgery. 4th Congr. Eur. Soc. Pneumology, Milano and Stresa, Italy, September, 1985; A 156, Abstract
   Google Scholar
• Weaver L. J., Simonowitz D., Driscoll R., Solliday N. Serum angiotensin converting enzyme in patients with Crohn's disease. J. Surg. Res. 1980; 29: 475
   PubMedGoogle Scholar
• Silverstein E., Fierst S. M., Simon M. R., Weinstock J. V., Friedland J. Angiotensin converting enzyme in Crohn's disease and ulcerative colitis. Am. J. Clin. Pathol. 1981; 75: 175
   PubMed Web of Science ®Google Scholar
• Fourrier F., Chopin C., Wallaert B., Wattre P., Mangalaboyi J., Durocher A., Dubois D., Wattel F. Angiotensin-converting enzyme in human adult respiratory distress syndrome. Chest 1983; 83: 593
   PubMed Web of Science ®Google Scholar
• Sharma O. P., Vita J. B. Determination of angiotensin-converting enzyme activity in tears. A noninvasive test for evaluation of ocular sarcoidosis. Arch. Ophthalmol. 1983; 101: 559
   PubMedGoogle Scholar
• Oksanen V., Grönhagen-Riska C., Fyhrqvist F., Somer H. Systemic manifestations and enzyme studies in sarcoidosis with neurologic involvement. ACTA Med. Scand. 1985; 218: 123
   PubMedGoogle Scholar
• Chan Seem C. P., Norfolk G., Spokes E. G. CSF angiotensin-converting enzyme in neurosar-coidosis. Lancet 1985; I: 456
   Google Scholar
• Lanzillo J. J., Fanburg B. Angiotensin converting enzyme in bronchoalveolar lining fluid. Lancet 1979; I: 1200
   Google Scholar
• Perrin-Fayolle M., Pacheco Y., Harf R., Montagnon B., Biot N. Angiotensin converting enzyme in bronchoalveolar lavage fluid in pulmonary sarcoidosis. Thorax 1981; 34: 790
   Google Scholar
• Gupta R. G., Sicilian L., Catchatourian R., Bekerman C, Oparil S., Szidon J. P. Angiotensin-converting enzyme in serum and in bronchoalveolar lavage in sarcoidosis. Respiration 1982; 43: 153
   PubMedGoogle Scholar
• Rohatgi P. K., Ryan J. W. Serum angiotensin converting enzyme (SACE) and carboxypeptidase N (CPN) activities in sarcoidosis and other chronic lung diseases. Am. Rev. Respir. Dis. 1982; 125(4, 2)115
   Google Scholar
• Schweisfurth H., Heinrich J., Brugger E., Burghardt W. Veränderungen der Carboxypeptidase N im Serum bei Patienten mit Lungensarkoidoise. Dtsch. Med. Wochenschr. 1984; 109: 166
   PubMedGoogle Scholar
• Reitamo S., Klockars M., Adinolfi M., Osserman E. F. Human lysozyme. Origin and distribution in health and disease. Ric. Clin. Lab. 1978; 8: 211
   PubMedGoogle Scholar
• Osserman E. F., Lawlor D. P. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J. Exp. Med. 1966; 124: 921
   PubMed Web of Science ®Google Scholar
• Klockars M., Selroos O. Elevated muramidase levels in histiocytic medullary reticulosis. N. Engl. J. Med. 1976; 294: 901
   PubMedGoogle Scholar
• Pascual R. S., Gee J. B. L., Finch S. C. Usefulness of serum lysozyme measurement in diagnosis and evaluation of sarcoidosis, A′. Engl. J. Med. 1973; 289: 1074
   PubMed Web of Science ®Google Scholar
• Selroos O., Klockars M. Serum lysozyme in sarcoidosis. Evaluation of its usefulness in determination of disease activity. Scand. J. Respir. Dis. 1977; 58: 110
   PubMedGoogle Scholar
• Morishita M. Serum lysozyme level in patients with sarcoidosis. Nagoya Med. J. 1976; 21: 183
   Google Scholar
• Cumminskey J. M., Melinn M., McLaughlin M. Lysozyme levels in sarcoidosis. Isr. J. Med. Sci. 1978; 147: 108
   Google Scholar
• Torii Y., Yamamoto M., Morishita M., Sugiura T., Suzuki T. Serum angiotensin converting enzyme (ACE) and serum lysozyme in sarcoidosis and other granulomatous diseases. Sarcoidosis, R. Mikami, Y. Hosoda. University of Tokyo Press, Japan 1981; 191
   Google Scholar
• Schmekel B., Hällgren R., Stålenheim G., Venge P. Indices of inflammatory cell activity and pulmonary function in different stages of sarcoidosis. Acta Med. Scand. 1982; 211: 393
   PubMedGoogle Scholar
• Klockars M., Selroos O. Immunohistochemical demonstration of lysozyme in the lymph nodes and Kveim reaction papules in sarcoidosis. Acta Pathol. Microbiol. Scand. Sect. A 1977; 85: 169
   Google Scholar
• Silverstein E., Friedland J., Ackerman T. Elevation of granulomatous lymph node and serum lysozyme in sarcoidosis and correlation with angiotensin-converting enzyme. Am. J. Clin. Pathol. 1977; 68: 219
   PubMed Web of Science ®Google Scholar
• Koivunen E., Grönhagen-Riska C, Klockars M., Selroos O. Blood monocytes and serum and bone marrow lysozyme in sarcoidosis. Acta Med. Scand. 1981; 210: 107
   PubMedGoogle Scholar
• Selroos O., Tiitinen H., Grönhagen-Riska C, Fyhrqvist F., Klockars M. Angiotensin-converting enzyme and lysozyme in sarcoidosis. Sarcoidosis and Other Granulomatous Diseases, W. Jones Williams, B. H. Davies. Alpha Omega, Cardiff, Wales 1980; 303
   Google Scholar
• Römer F., Ahlbom G., Jensen J. U. Relationship between angiotensin-converting enzyme and lysozyme in sarcoidosis. Eur. J. Respir. Dis. 1982; 63: 330
   PubMedGoogle Scholar
• Bernier G. M., Fanger M. W. Synthesis of β2-microglobulin in stimulated lymphocytes. J. Immunol. 1972; 109: 407
   PubMed Web of Science ®Google Scholar
• Child J. A., Spati B., Illingworth S. Serum β2-microglobulin and C reactive protein in the monitoring of lymphomas. Cancer. 1980; 45: 318
   PubMed Web of Science ®Google Scholar
• Jonasson L. E., Evrin P. E., Wibell L. Content of β2-microglobulin and albumin in human amiotic fluid. Acta Obstet. Gynecol. Scand. 1974; 53: 49
   PubMed Web of Science ®Google Scholar
• Teasdale C., Mander A. M., Fifield R., Keyser J. W., Newcombe R. G., Hughes L. E. Serum β2-microglobulin in controls and cancer patients. Clin. Chim. Acta 1977; 78: 135
   PubMed Web of Science ®Google Scholar
• Talal N., Grey H. M., Zvaifler N., Michalskin J. P., Daniels T. E. Elevated salivary and synovial fluid β2-microglobulin in Sjögren's syndrome and rheumatoid arthritis. Science. 1975; 187: 1169
   Google Scholar
• Mornex J. F., Revillard J. P., Vincent C, Deteix P., Brune J. Elevated serum β2-microglobulin levels and Cl4,-binding immune complexes in sarcoidosis. Biomedicine 1979; 31: 210
   PubMedGoogle Scholar
• Mornex J. F., Guibaud S., Simplot A., Plumet A., Guillot Y. L., Guerin J. C, Brune J., Vincent C, Revillard J. P. Relevance of broncho-alveolar lavage fluid levels of β2-microgIublin, angiotensin converting enzyme and lysozyme to inflammatory and immune processes within the lung. Proc. Annu. Meet. Eur. Acad. Allergology Clin. Immunol., C Molina. Lavoisier, Paris 1981; Vol. 2: 597
   Google Scholar
• Mornex J. F., Biot N., Pacheco Y., Perrin-Fayolle M., Vincent C, Revillard J. P. Beta 2 microglobulin levels in serum and bronchoalveolar lavage fluid from patients with sarcoidosis. Sarcoidosis and Other Granulomatous Disorders, J. Chrétien, J. Marsac, J. C Saltiel. Pergamon Press, Paris 1983; 372
   Google Scholar
• Parrish R. W., Williams J. D., Davies B. H. Serum β2microglobulin and angiotensin converting enzyme activity in sarcoidosis. Sarcoidosis and Other Granulomatous Disorders, J. Chrètien, J. Marsac, J. C Saltiel. Pergamon Press, Paris 1983; 366
   Google Scholar
• Morishita M., Torii Y., Ichimura K., Takada K., Suzuki M., Ina Y., Aoki H., Sugiura T., Yamamoto M. Serum and broncho-alveolar lavage level of beta-2-microglobulin in patients with sarcoidosis. Sarcoidosis and Other Granulomatous Disorders, J. Chrétien, J. Marsac, J. C Saltiel. Pergamon Press, Paris 1983; 383
   Google Scholar
• Klockars M., Pettersson T., Weber T. H., Fröseth B., Selroos O. Angiotensin-converting enzyme, lysozyme, beta-2-microglobulin and adenosine deaminase in sarcoidosis. Arch Monaldi 1984; 39: 345
   PubMedGoogle Scholar
• Selroos O. Staging of sarcoidosis by using ACE and β2M determinations in serum. 4th Congr. Eur. Soc. Pneumol. Milano and Stresa, Italy September, 1985; A/154, Abstract
   Google Scholar
• Hovi T., Smyth J. F., Allison A. C, Williams S. C. Role of adenosine deaminase in lymphocyte proliferation. Clin. Exp. Immunol. 1976; 23: 395
   PubMed Web of Science ®Google Scholar
• Shore A., Dosch H-M., Gelfand E. W. Role of adenosinedeaminase in the early stages of precursor T cell maturation. Clin. Exp. Immunol. 1981; 44: 152
   PubMedGoogle Scholar
• Fischer D., van den Weyden M. B., Snyderman R., Kelle W. N. A role for adenosine deaminase in human monocyte maturation. J. Clin. Invest. 1976; 58: 399
   PubMed Web of Science ®Google Scholar
• Giblett E. R., Anderson J. E., Cohen F., Pollara B., Meuwissen H. J. Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 1972; 2: 1067
   PubMed Web of Science ®Google Scholar
• Taylor A. Serum adenosine deaminase activity is increased in sarcoidosis. Clin. Chem. 1984; 30: 499
   PubMedGoogle Scholar
• Klockars M., Petterson T., Selroos O., Weber T. Activity of serum adenosine deaminase in sarcoidosis. Clin. Chem. 1985; 31: 155
   PubMedGoogle Scholar
• Stojan B., Müller W., Wurm K., Tariverdian M. Die Kollagenpeptidase als Mass des Kollagenumsatzes bei Sarkoidose. Schw. Med. Wochenschr. 1973; 103: 337
   PubMedGoogle Scholar
• Werb Z., Gordon S. Secretion of a specific collagenase by stimulated macrophages. J. Exp. Med. 1975; 142: 346
   PubMed Web of Science ®Google Scholar
• Gadek J. E., Kelman J. A., Fells G., Weinberger S. E., Horwitz A. L., Reynolds H. Y., Fulmer J. D., Crystal R. G. Collagenase in the lower respiratory tract of patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 1979; 301: 737
   PubMed Web of Science ®Google Scholar
• Silverstein E., Lockerman Z., Friedland J. Serum and lymph node collagenase in sarcoidosis. Am. J. Clin. Pathol. 1978; 70: 348
   PubMedGoogle Scholar
• Rhode H., Vargas L., Hahn E., Kalbfleisch H., Bruguera M., Timple R. Radioimmunoassay for type III procollagen peptide and its application to human liver disease. Eur. J. Clin. Invest. 1979; 9: 451
   PubMed Web of Science ®Google Scholar
• Low R. B., Cutroneo K. R., Davies G. S., Giancola M. S. Lavage type III procollagen N-terminal peptides in human pulmonary fibrosis and sarcoidosis. Lab. Invest. 1983; 48: 755
   PubMed Web of Science ®Google Scholar
• Watanabe Y., Yamaki K., Yamakawa I., Takagi K., Satake T. Type III procollagen N-terminal peptides in experimental pulmonary fibrosis and human lung diseases. Eur. J. Respir. Dis. 1985; 67: 10
   PubMedGoogle Scholar
• Hällgren R., Eklund A., Engstrom-Laurent A., Schmekel B. Hyaluronate in bronchoalveolar lavage fluid: a new marker in sarcoidosis reflecting pulmonary disease. Br. Med. J. 1985; 290: 1778
   PubMed Web of Science ®Google Scholar
• Ruoslahti E., Engualle F., Hayman E. G. Fibronectin: current concepts of its structure and function. Collagen Res. 1981; 1: 95
   PubMed Web of Science ®Google Scholar
• Rennard S. I., Hunninghake G. W., Bitterman P. B., Crystal R. G. Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases. Proc. Natl. Acad. Sci. U.S.A. 1981; 78: 7147
   PubMed Web of Science ®Google Scholar
• Rennard S. I., Crystal R. G. Fibronectin in human bronchopulmonary lavage fluid: elevation of patients with interstitial lung disease. J. Clin. Invest. 1982; 69: 113
   PubMed Web of Science ®Google Scholar
• Gilbert H. S., Siltzbach L. E. Increased levels of circulating transcobalamine II in sarcoidosis. Sarcoidosis and Other Granulomatous Diseases, W. Jones Williams, B. H. Davies. Alpha Omega, Cardiff, Wales 1980; 485
   Google Scholar
• Selroos O. B. Value of biochemical markers in serum for determination of disease activity in sarcoidosis. Sarcoidosis 1984; 1: 45
   PubMedGoogle Scholar