13
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Tumor Detection Using Radiolabeled Monoclonal Antibodies

, , &
Pages 313-351 | Published online: 27 Sep 2008

References

  • Foley E. J. Antigen properties of methylcholanthrene-induced tumors in mice of strain of origin. Cancer Res. 1953; 13: 835
  • Wolf P., Reid D. Tumor associated markers. Tumor Imaging the Radiochemical Detection of Cancer, S. W. Burchiel, B. A. Rhodes. Masson Publishing, New York 1982; 5
  • Pressman D., Keighley G. The zone of activity of antibodies as determined by the use of radioactive tracers; the zone of activity of nephritoxic antikidney serum. J. Immunol. 1948; 59: 141
  • Reif A. E., Curtis L. E., Duffield R., Shauffer I. A. Trial of radiolabeled antibody localization in metastases of a patient with tumor containing carcinoembryonic antigen (CEA). J. Surg. Oncol. 1974; 6: 133
  • Math J. P., Carrell S., Merenda C., Heumann D., Roenspies U. In vivo localization of anti-CEA antibody to colon carcinoma. Can the results obtained in the nude mice model be extrapolated to the patient situation?. Eur. J. Cancer Suppl. 1978; 1: 113
  • Goldenberg D. M., Kim E. E., DeLand F. H., Bennett S., Primus F. J. Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Res. 1980; 40: 2984
  • Kohler G., Milstein C. Continuous cultures of fused cells secreting antibodies of predefined specificity. Nature (London) 1975; 256: 495
  • Steplewski Z., Koprowski H. Anti-colorectal carcinoma monoclonal antibodies. Hybridomas in Cancer Diagnosis and Treatment, M. S. Mitchell, H. F. Oettgen. Raven Press, New York 1982; 207
  • Dippold W. G., Lloyd K. O., Li L. T. C., Ikeda H., Oettgen H. F., Old L. J. Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies. Proc. Natl. Acad. Sci. U.S.A. 1980; 77: 6114
  • Colcher D., Hand Horan P., Nuti M., Schlom J. Differential binding to human mammary and non-mammary tumors of monoclonal antibodies reactive with carcinoembryonic antigen. Cancer Invest. 1983; 1: 127
  • Primus F. J., Newell K. D., Blue A., Goldenberg D. M. Immunological heterogeneity of carcinoembryonic antigen: antigenic determinants on carcinoembryonic antigen distinguished by monoclonal antibodies. Cancer Res. 1983; 43: 686
  • Sears H. F., Atkinson B., Herlyn D., Ernst C., Mattis J., Steplewski Z., Hayry P., Koprowski H. The use of monoclonal antibody in the phase I clinical trial of human gastrointestinal tumors. Lancet 1982; 1: 762
  • Goldenberg D. M., Kim E. E., DeLand F., et al. Clinical studies on the radioimmunodetection of tumors containing alpha-fetoprotein. Cancer 1980; 45: 2500
  • Dillman R. O., Beauregard J. C., Sobol R. E., Royston I., Bartholomew R. M., Hagan P. S., Halpern S. E. Lack of radioimmunodetection and complications associated with monoclonal anticarcinoembryonic antigen antibody cross-reactivity with an antigen on circulating cells. Cancer Res. 1984; 44: 2213
  • Colcher D., Zalutsky M., Kaplan W., Kufe D., Austin F., Schlom J. Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody. Cancer Res. 1983; 43: 736
  • Wahl R. L., Parker C. W., Philpott G. W. Improved radioimaging and tumor localization with monoclonal F(ab')2. J. Nucl. Med 1983; 24: 316
  • Herlyn D., Powe J., Alavi A., Mattis J. A., Herlyn M., Ernst C., Vaum R., Koprowski H. Radioimmunodetection of human tumor xenografts by monoclonal antibodies. Cancer Res. 1983; 43: 2731
  • Begent R. H. J., Keep P. A., Green A. J., Searle F., Bagshawe K. D., Jewkes R. F., Jones B. E., Barratt G. M., Ryman B. E. Liposomally entrapped second antibody improves tumor imaging with radiolabeled (first) antitumor antibody. Lancet 1982; 2: 739
  • Kearney J. F., Radbruch A., Leisegang B., Rajewsky K. A new mouse myeloma cell line that has lost immunologic expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 1979; 23: 1548
  • Koprowski H., Steplewski Z., Herlyn D., Herlyn M. Studies of antibodies against human melanoma produced by somatic cell hybrids. Proc. Natl. Acad. Sci. U.S.A. 1978; 75: 3405
  • Herlyn M., Steplewski Z., Herlyn D., Clark W. H., Ross A. H., Blaszczyk M., Pak K. Y., Koprowski H. Production and characterization of monoclonal antibodies against human malignant melanoma. Cancer Invest. 1983; 1: 215
  • Powe J., Herlyn D., Alavi A., Munz D., Steplewski Z., Koprowski H. Radioimmunodetection of human tumor xenografts by monoclonal antibodies correlates with antibody density and affinity. Immunoscintigraphy, K. Britton, L. Donato. Gordon and Breach Science Publishers, New York 1985; 139
  • Herlyn D., Herlyn M., Ross A. H., Ernst C., Atkinson B., Koprowski H. Efficient selection of human tumor growth inhibiting monoclonal antibodies. J. Immunol. Methods 1984; 73: 157
  • Handley H., Glassy M., Cleveland P., Royston I. Development of rapid micro ELISA assay for screening hybridoma supernatants for murine monoclonal antibodies. J. Immunol, Methods 1982; 54: 291
  • Feit C., Bartal A., Tauber G., Dymbort G., Hirshaut Y. An enzyme-linked immunosorbent assay for the detection of monoclonal antigens expressed on viable cells. J. Immunol. Methods 1983; 58: 301
  • Birkmeyer R., Clark S., Karol R., Lynch J., Reider M. Rapid selection of monoclonal antibodies with high specificity and sensitivity. Hybridoma 1985; 4: 69
  • Herlyn M., Steplewski Z., Herlyn D., Koprowski H. Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. Proc. Natl. Acad. Sci. U.S.A. 1979; 76: 1438
  • Herlyn M., Clark W., Mastrangelo M., et al. Specific immunoreactivity of hybridoma secreted monoclonal antibodies to cultured cells and freshly derived human cells. Cancer Res. 1980; 40: 3602
  • Posner M., Antoniou D., Griffen J., Schlossman S., Lazarus H. An enzyme linked immunosorbent assay for the detection of monoclonal antibodies to cell surface antigens on viable cells. J. Immunol. Methods 1982; 48: 23
  • Buick R., Pullano R., Bizzani J. P., MacKillop W. The phenotypic heterogeneity of human ovarian tumor cells in relation to cell function. Radioimmunoimaging and Radioimmunotherapy, S. W. Burchiel, B. A. Rhodes. Elsevier, New York 1983; 11
  • Burchiel S., Martin J., Imai K., Ferrone S., Warner N. Heterogeneity of HLB-A, B., la-like and melanoma-associated antigen expression of human melanoma cell lines analyzed with monoclonal antibodies and flow cytometry. Cancer Res. 1982; 42: 4110
  • Hand Horan P., Nuti M., Colcher D., Seldom J. Definition of antigenic heterogeneity and modulation among human mammary carcinoma cell populations using monoclonal antibodies to tumor associated antigens. Cancer Res. 1983; 43: 728
  • Fabre J., Daar A. Expression of normal epithelial membrane antigens on human colorectal and breast carcinomas: demonstration of hitherto unrecognized heterogeneity within and between tumors. Radioimmunoimaging and Radioimmunotherapy, S. W. Burchiel, B. A. Rhodes. Elsevier, New York 1983; 143
  • Poste G., Doll J., Brown A., Tzeng J., Zeidman I. Comparison of the metastatic properties of B16 melanoma clones isolated from cultured cell lines, subcutaneous tumors and individual lung metastases. Cancer Res. 1982; 42: 2770
  • Harris J., Chambers A., Hill R., Ling V. Metastatic variants are generated spontaneously at a high rate in mouse KHT tumor. Proc. Natl. Acad. Sci. U.S.A. 1982; 79: 5547
  • Fogel M., Gorelik E., Segal S., Feldman M. Differences in cell surface antigens of tumor metastases and those of the local tumor. J. Natl. Cancer Inst. 1979; 62: 585
  • Atkinson B., Ernst C., Herlyn M., Steplewski Z., Sears H., Koprowski H. Gastrointestinal cancer-associated antigens in immunoperoxidase assay. Cancer Res. 1983; 42: 4820
  • Lubeck M., Steplewski Z., Scharff M., Spira G., Koprowski H. Monoclonal antibodies in destruction of human tumor cells in vitro by human monocytes. Hybridoma 1985; 4: 58
  • Stanker L., Vanderlaan M., Juarez-Salinas H. One-step purification of mouse monoclonal antibodies from ascites fluid by hydroxylapatite chromatography. J. Immunol. Methods 1985; 76: 157
  • Herlyn D., Koprowski H. Ig G2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells. Proc. Natl. Acad. Sci. U.S.A. 1982; 79: 4761
  • Lamoyi E., Nisonoff A. Preparation of F(ab')2 fragments from mouse Ig G of various subclasses. J. Immunol. Methods 1983; 56: 235
  • Chatal J. F., Saccavini J. C., Fumoleau P., et al. Immunoscintigraphy of colon carcinoma. J. Nucl. Med. 1984; 25: 307
  • Ballou B., Reiland J., Levine G., Knowles B., Hakala T. Tumor localization using F(ab')2u from a monoclonal antibody, Pharmacokinetics. J. Nucl. Med. 1985; 26: 283
  • Pollock R., Metlay J., Thammana P., et al. Generation of mutant monoclonal antibodies with changes in biological function. Radioimmunoimaging and Radioimmunotherapy, S. W. Burchiel, B. A. Rhodes. Elsevier, New York 1983; 93
  • Primus F., Bennett S., Kim E., DeLand F., Zahn M., Goldenberg D. Circulating immune complexes in cancer patients receiving goat radiolocalizing antibodies to carcinoembryonic antigen. Cancer Res. 1980; 40: 497
  • Rhodes B., Burke D., Breslow K., Reed K., Austin R., Burchiel S. Effects of circulating antigen on antibody localization in vivo. Radioimmunoimaging and Radioimmunotherapy, S. W. Burchiel, B. A. Rhodes. Elsevier, New York 1983; 25
  • Hagan P., Halpern S., Chen A., et al. Effect of tumor size, CEA production and secretion on the distribution of111 In and 125I monoclonal antitumor antibodies in animal models. J. Nucl. Med. 1983; 24: 77
  • Steplewski Z., Chang T., Herlyn M., Koprowski H. Release of monoclonal antibody defined antigens by human colorectal carcinoma and melanoma cells. Cancer Res. 1981; 41: 2723
  • Herlyn M., Sears H., Steplewski Z., Koprowski H. Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric and pancreatic carcinoma. J. Clin. Immunol. 1982; 2: 135
  • Partridge C., Britton D., Bagshawe K. Use of the direct linear plot to estimate, in an immunoglobulin solution, the proportion which is specific monoclonal antibody against an unknown cell surface antigen. J. Immunol. Methods 1985; 78: 95
  • Kennel S., Foote L., Lankford P., Johnson M., Mitchell T., Braslawsky G. Direct binding of radioiodinated monoclonal antibody to tumor cells: significance of antibody purity and affinity for drug targeting or tumor imaging. Hybridoma 1983; 2: 297
  • Herlyn D., Powe J., Ross A., Herlyn M., Koprowski H. Inhibition of human tumor growth by Ig G2a monoclonal antibodies correlates with antibody density on tumor cells. J. Immunol 1985; 134: 1300
  • Larson S., Brown J., Wright D., Carrasquillo J., Hellstrom I., Hellstrom K. Imaging of melanoma with 131I labeled monoclonal antibodies. J. Nucl. Med. 1983; 24: 123
  • Halpern S., Stern P., Hagan P., et al. Radiolabeling of monoclonal antitumor antibodies: comparison of I-125 and In-III anti-CEA with Ga-67 in a nude mouse-human colon tumor model. Clin. Nucl. Med. 1981; 6: 453
  • Halpern S., Hagan P., Garver P., et al. Stability, characterization and kinetics of III-In-labeled monoclonal antitumor antibodies in normal animals and nude mouse-human tumor models. Cancer Res. 1983; 43: 5437
  • Trucco M., Petris S. Determination of equilibrium binding parameters of monoclonal antibodies specific for cell surface antigens. Immunological Methods, B. Lefkovits, Pernis. Academic Press, New York 1981; Vol. 2: 1
  • Larson S., Carrasquillo J., Reynolds J. Radioimmunodetection and radioimmunotherapy. Cancer Invest. 1984; 2: 363
  • Larson S. Radiolabeled monoclonal anti-tumor antibodies in diagnosis and therapy. J. Nucl. Med. 1985; 26: 538
  • Greiner J., Hand Horan P., Noguchi P., Fisher P., Pestka S., Schlom J. Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment. Cancer Res. 1984; 44: 3208
  • Thompson D., Neville M., Phelan K., Schwartz-Scanzano R., Vandervoorde J. Human cancers transplanted in nude mice retain the expression of their organ-specific neoantigens. Eur. J. Cancer Clin. Oncol. 1981; 17: 1191
  • Gallagher B. M. Monoclonal antibodies: the design of appropriate carrier and evaluation systems. Animal Models in Radiotracer Design, R. M. Lambrecht, W. C. Eckelman. Springer-Verlag, New York 1983; 61
  • Aamdal S., Fodstad O., Nesland J., Pihl A. Characteristics of human tumor xenografts transplanted under the renal capsule of immunocompetent mice. Br. J. Cancer 1985; 51: 347
  • Solesvik O., Rofstad E., Brustad T. Vascular structure of five human malignant melanomas grown in athymic nude mice. Br. J. Cancer 1982; 46: 557
  • Gallagher B., Sands H., Neacey W., Jones P., Shah S. Monoclonal antibody localization and imaging of human mammary carcinoma grown at various sites in the nude mouse. J. Nucl. Med. 1984; 25: P112
  • Moshakis V., McLlhinney R., Raghavan D., Neville A. M. Localization of human tumor xenografts after i.v. administration of radiolabeled monoclonal antibodies. Br. J. Cancer 1981; 44: 91
  • Mann B., Cohen M., Saxton R., et al. Imaging of human tumor xenografts in nude mice with radiolabeled monoclonal antibodies. Cancer 1984; 54: 1318
  • Sands H., Jones P., Neacy W., Shah S., Gallagher B. The imaging of small experimental murine tumors grown in the subrenal capsule using monoclonal antibodies. Cancer Lett. 1984; 24: 65
  • Spiegelberg H., Weigle W. The catabolism of homologous and heterologous 7S gamma globulin fragments. J. Exp. Med. 1965; 121: 323
  • O'Connor S., Bale W. Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors. Cancer Res. 1984; 44: 3719
  • Buchegger F., Haskell C., Schreyer M., et al. Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice. J. Exp. Med. 1983; 158: 413
  • Hagan P., Halpern S., Chen A. Comparison of In-111 labeled Fab and whole In-111 anti-CEA monoclonal antibody in normal mouse-human colon tumor models. J. Nucl. Med. 1983; 24: 77
  • Khaw B., Strauss W., Cahill S., Soule H., Edgington T., Cooney J. Sequential imaging of indium-111 labeled monoclonal antibody in human mammary tumors hosted in nude mice. J. Nucl. Med. 1984; 25: 592
  • Powe J., Pak K., Paik C., et al. Labeling monoclonal antibodies and F(ab')2 fragments with 111-Indium using cyclic DTPA anhydride and their in vivo behavior in mice bearing human tumor xenografts. Cancer Drug Delivery 1984; 1: 125
  • Moldofsky P., Powe J., Mulhern C., et al. Metastatic colon carcinoma detected with radiolabeled F(ab')2 monoclonal antibody fragments. Radiology 1983; 149: 549
  • Mach J. P., Chatal J. F., Lumbroso J. D., et al. Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma. Cancer Res. 1983; 43: 5593
  • Mach J. P., Grob J.-Ph., Buchegger F., Volant J. C., von Fliedner V., Carrel S., Bischof-Delaloye A., Delaloye B. FAB fragments of monoclonal anti-CEA antibodies can improve the in-vivo detection of colon carcinomas by immunoscintigraphy. Proc. Int. Symp. on Monoclonal Antibodies '84: Biological and Clinical Applications, A. Pinchera, G. Doria, F. Dammacco, A. Bargellesi. Editrice Kurtis, MilanoItaly 1985; 405
  • Rockoff D., Goodenough D., McIntire R. Theoretical limitations in the immunodiagnostic imaging of cancer with computer tomography and nuclear scanning. Cancer Res. 1980; 40: 3054
  • DeLand F. H., Goldenberg D. M. Diagnosis and treatment of neoplasms with radionuclide-labeled antibodies. Semin. Nucl. Med. 1985; 15(1)2
  • Larson S. M., Carrasquillo J. A. Nuclear oncology 1984. Semin. Nucl. Med. 1984; 14(4)268
  • Halpern S. E., Dillman R. O., Hagan P. L. The problems and promise of monoclonal antitumor antibodies. Diagn. Imaging 1983; 5(6)40
  • Nuclear Medicine Annual, L. M. Freeman. Raven Press, New York 1983
  • Tumor Imaging: The Radio-Immunochemical Detection of Cancer, S. W. Burchiel, B. A. Rhodes. Masson Publishing, New York 1982
  • Radioimmunoimaging and Radioimmunotherapy, S. W. Burchiel, B. A. Rhodes. Elsevier, New York 1983
  • Goldenberg D. M., DeLand F., Kim E., et al. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N. Engl. J. Med. 1978; 298: 1384
  • Order S. E. The history and progress of serologic immunotherapy and radiodiagnosis. Radiology 1976; 118: 219
  • Mach J. P., Buchegger F., Forni M., et al. Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunol. Today 1981; 2: 239
  • Koprowski H., Steplewski Z., Mitchell K., Herlyn M., Herlyn D., Fuhrer P. Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet. 1979; 5: 957
  • Burchiel S. W., Khaw B. A., Rhodes B. A., Smith T. W., Haber E. Immunopharmacokinetics of radiolabeled antibodies and their fragments. Tumor Imaging. The Radioimmunochemical Detection of Cancer, S. W. Burchiel, B. A. Rhodes, B. E. Friedman. Masson Publishing, New York 1982; 125
  • Fraker P. J., Speck J. C., Jr. Protein and cell membrane iodinations with a sparingly soluble chloroamide l,3,4,6-tetrachloro-3a, 6a-diphenylglycoluril. Biochem. Biophys. Res. Commun. 1978; 80: 849
  • Hawk's Physiological Chemistry14th ed., B. L. Oser. McGraw-Hill, New York 1965; 1029
  • Imai K., Yachi A., Ferrone S. Preparation and characterization of monoclonal antibodies to human melanoma-associated antigens (MAA). Tumor Imaging. The Radioimmunochemical Detection of Cancer, S. W. Burchiel, B. A. Rhodes, B. E. Friedman. Masson Publishing, New York 1982; 141
  • Pavel D. G., Zimmer A. M., Patternson V. N. In vivo labeling of red blood cells with 99m Tc: a new approach to blood pool visualization. J. Nucl. Med. 1977; 18: 305
  • DeLand F. H., Kim E. E., Simmons G., Goldenberg D. M. Imaging approach in radioim-munodetection. Cancer Res. 1980; 40: 3046
  • Tracer principles. Basic Science Principles of Nuclear Medicine, C. M. Boyd, G. V. Dalrymple. C. V. Mosby, St. Louis 1974; 107
  • Thomas S. R., Maxon H. R., Kereiakes J. G., Sacnger E. L. Quantitative external counting techniques enabling improved diagnostic and therapeutic decisions in patients with well-differentiated thyroid cancer. Radiology 1977; 122: 731
  • Moldofsky P. J., Sears H. F., Mulhern C. B., et al. Detection of metastatic tumor in normal sized retroperitoneal lymph nodes using radiolabeled monoclonal antibody imaging. N. Engl. J. Med. 1984; 311(2)106
  • Hammond N. D., Moldofsky P. J., Beardsley M. R., Mulhern C. B. External imaging techniques for quantitation of distribution of 1–131 F(ab')2 fragments of monoclonal antibody in humans. Med. Phys. 1984; 11(6)778
  • Bureau of Radiological Health and Training Environmental Control Administration. Radiological Health Handbookrevised ed. Public Health Service, U.S. Department of Health, Education, and Welfare, Washington, DC January, 1970
  • Hammond N. D., Moldofsky P. J., Exten R. A., et al. Development, evaluation and in-vivo validation of two non-invasive methods for quantitation of activity and dosimetry of monoclonal antibodies in humans. J. Nucl. Med. 1985; 26: 61, (5‘P’)
  • Snyder W. A., Ford M. R., Warner G. G. Estimates of specific absorbed fractions for photon sources uniformly distributed in various organs of a heterogeneous phantom. Health Physics Division, Oak Ridge National Laboratory, Oak Ridge, Tenn. 1978, MIRD Pamphlet No. 5

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.