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Research Article

Aluminum and Chronic Renal Failure: Sources, Absorption, Transport, and Toxicity

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Pages 59-107 | Published online: 27 Sep 2008

References

  • Wills M. R., Savory J. Aluminium poisoning: dialysis encephalopathy, osteomalacia and anaemia. Lancet 1983; 2: 29
  • Savory J., Wills M. R. Analytical methods for aluminum measurement. Kidney Int. 1986; 29: S24
  • Versieck J., Cornells R. Normal levels of trace elements in human blood plasma or serum. Anal. Chim. Acta 1980; 116: 217
  • Burnatowska-Hledin M. A., Mayor G. H., Lau K. Renal handling of aluminum in the rat: clearance and micropuncture studies. Am. J. Physiol. 1985; 249: F192
  • Pennington J. A. T. Aluminum content of foods and diets. Food Addit. Contam. 1987; 5: 161
  • Lione A. The prophylactic reduction of aluminium intake. Food Chem. Toxicol. 1983; 21: 103
  • Tennakone K., Wickramanayake S. Aluminium leaching from cooking utensils. Nature (London) 1987; 325: 202
  • Savory J., Nicholson J. R., Wills M. R. Is aluminium leaching enhanced by fluoride?. Nature (London) 1987; 327: 107
  • Cornells R., Schutyser P. Analytical problems related to Al-determination in body fluids, water and dialysate. Contrib. Nephrol. 1984; 38: 1
  • Sorensen J. R. J., Campbell I. R., Tepper L. B., Lingg R. D. Aluminum in the environment and human health. Environ. Health Perspect. 1974; 8: 3
  • Nagy S., Nikdel S. Tin, iron, and aluminum contents of commercially canned single-strength grapefruit juice stored at varying temperature. J. Agric. Food Chem. 1986; 34: 588
  • Lione A., Allen P. V., Smith J. C. Aluminium coffee percolators as a source of dietary aluminium. Food Chem. Toxicol. 1984; 22: 265
  • Coriat A. M., Gillard R. D. Beware the cups that cheer. Nature (London) 1986; 321: 570
  • Fairweather-Tait S. J., Moore G. R., Jemil Fatemi S. E. Low levels of aluminium in tea. Nature (London) 1987; 330: 213
  • Koch K. R., Bruno Pougnet M. A., De Villiers S., Monteagudo F. Increased urinary excretion of Al after drinking tea. Nature (London) 1988; 333: 122
  • Freundlich M., Zilleruelo G., Abitbol C, Strauss J., Faugere M. C., Malluche H. H. Infant formula as a cause of aluminium toxicity in neonatal uraemia. Lancet 1985; 2: 527
  • Koo W. W. K., Kaplan L. A., Krug-Wispe S. K. Aluminum contamination of infant formulas. J. Parenteral Enteral Nutr. 1988; 12: 170
  • Sedman A. B., Klein G. L., Merritt R. J., Miller N. L., Weber K. O., Gill W. L., Anand H., Alfrey A. C. Evidence of aluminum loading in infants receiving intravenous therapy. N. Engl. J. Med. 1985; 312: 1337
  • Weintraub R., Hams G., Meerkin M., Rosenberg A. R. High aluminium content of infant milk formulas. Arch. Dis. Child. 1986; 61: 914
  • McGraw M., Bishop N., Jameson R., Robinson M. J., O'Hara M., Hewitt C. D., Day J. P. Aluminium content of milk formulae and intravenous fluids used in infants. Lancet 1986; 1: 157
  • Robinson M. J., Ryan S. W., Newton C. J., Day J. P., Hewitt C. D., O'Hara M. Blood aluminium levels in preterm infants fed parenterally or with cows' milk formulae. Lancet 1987; 2: 1206
  • Miller R. G., Kopfler F. C, Kelty K. C, Stober J. A., Ulmer N. S. The occurrence of aluminum in drinking water. J. Am. Water Works Assoc. 1984; 76: 84
  • Cronan C. S., Schofield C. L. Aluminum leaching response to acid precipitation: effects on high-elevation watersheds in the northeast. Science 1979; 204: 304
  • Committee on the Atmosphere and Biosphere. National Research Council. Atmosphere-Biosphere Interactions: Toward a Better Understanding of the Ecological Consequences of Fossil Fuel Combustion. National Academy Press, Washington, DC 1981
  • Luoma J. R. Troubled Skies, Troubled Waters: The Story of Acid Rain. Viking Press, New York 1984
  • Mohnen V. A. The challenge of acid rain. Sci. Am. 1988; 259: 30
  • Shortle W. C., Smith K. T. Aluminum-induced calcium deficiency syndrome in declining red spruce. Science 1988; 240: 107
  • Baker J. P., Schofield C. L. Aluminum toxicity to fish in acidic waters. Water Air Soil Pollut. 1982; 18: 289
  • Driscoll C. T., Jr, Baker J. P., Bisgoni J. J., Jr, Schofleld C. L. Effect of aluminium speciation on fish in dilute acidified waters. Nature (London) 1980; 284: 161
  • Howells G. D., Kallend A. S. Acid rain-the CEGB view. Chem. Br. 1984; 20: 407
  • Parkinson I. S., Ward M. K., Kerr D. N. S. Dialysis encephalopathy, bone disease and anaemia: the aluminium intoxication syndrome during regular haemodialysis. J. Clin. Pathol. 1981; 34: 1285
  • Nordai K. P., Dahl E., Thomassen Y., Brodwall E. K., Halse J. Seasonal variations in serum aluminum concentrations. Pharmacol. Toxicol. USSR 1988; 62: 80
  • Sedman A. B., Miller N. L., Warady B. A., Lum G. M., Alfrey A. C. Aluminum loading in children with chronic renal failure. Kidney Int. 1984; 26: 201
  • Sedman A. B., Wiikening G. N., Warady B. A., Lum G. M., Alfrey A. C. Encephalopathy in childhood secondary to aluminum toxicity. J. Pediatr. 1984; 105: 836
  • Andreoli S. P., Bergstein J. M., Sherrard D. J. Aluminum intoxication from aluminum-containing phosphate binders in children with azotemia not undergoing dialysis. N. Engl. J. Med. 1984; 310: 1079
  • Salusky I. B., Coburn J. W., Paunier L., Sherrard D. J., Fine R. N. Role of aluminum hydroxide in raising serum aluminum levels in children undergoing continuous ambulatory peritoneal dialysis. J. Pediatr. 1984; 105: 717
  • Andreoli S. P., Smith J. A., Bergstein J. M. Aluminum bone disease in children: radiographic features from diagnosis to resolution. Radiology 1985; 156: 663
  • Flendrig J. A., Kruis H., Das H. A. Aluminium and dialysis dementia. Lancet 1976; 1: 1235
  • Platts M. M., Goode G. C, Hislop J. S. Composition of die domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis. Br. Med. J. 1977; 2: 657
  • Parkinson I. S., Ward M. K., Feest T. G., Fawcett R. W. P., Kerr D. N. S. Fracturing dialysis osteodystrophy and dialysis encephalopathy. An epidemiological survey. Lancet 1979; 1: 406
  • Ward M. K., Feest T. G., Ellis H. A., Parkinson I. S., Kerr D. N. S., Herrington J., Goode G. L. Osteomalacic dialysis osteodystrophy: evidence for a water-borne aetiological agent, probably aluminium. Lancet 1978; 1: 841
  • Savory J., Berlin A., Courtoux C., Yeoman B., Wills M. R. Summary report of an international workshop on “The role of biological monitoring in the prevention of aluminum toxicity in man: aluminum analysis in biological fluids,”. Ann. Clin. Lab. SCi. 1983; 13: 444
  • Raciti A., Kelleher S., Savory J., Wills M. R. Aluminum (A1) transfer during hemodialysis is independent of dialysate pH (DpH). Kidney Int. 1987; 31: 243
  • Martin R. B. The chemistry of aluminum as related to biology and medicine. Clin. Chem. 1986; 32: 1797
  • Graf H., Stummvoll H. K., Meisinger V., Kovarik J., Wolf A., Pinggera W. F. Aluminum removal by hemodialysis. Kidney Int. 1981; 19: 587
  • Graf H., Stummvoll H. K., Meisinger V. Dialysate aluminium concentration and aluminium transfer during haemodialysis. Lancet 1982; 1: 46
  • Kaebny W. D., Alfrey A. C., Holmann R. E., Shorr W. J. Aluminum transfer during hemodialysis. Kidney Int. 1977; 12: 361
  • Savory J., Wills M. R. Dialysis fluids as a source of aluminum accumulation. Contrib. Nephrol 1984; 38: 12
  • Mauras Y., Allain P., Riberi P. Etude de l'absorption digestive de l'hydrocarbonate d'aluminium chez l'individu sain. Therapie 1982; 37: 593
  • Brown S., Mendoza N., Bertholf R. L., Ross R., Wills M. R., Savory J. Absorption of aluminum from aceglutamide aluminum in healthy adult males. Res. Commun. Chem. Pathol. Pharmacol. 1986; 53: 105
  • Larson E. A., Ash S. R., White J. L., Hem S. L. Phosphate binding gels: balancing phosphate adsorption and aluminum toxicity. Kidney Int. 1986; 29: 1131
  • Slanina P., Falkeborn Y., Freeh W., Cedergren A. Aluminium concentrations in the brain and bone of rats fed citric acid, aluminium citrate or aluminium hydroxide. Food Chem. Toxicol. 1984; 22: 391
  • Slanina P., Freeh W., Bemhardson A., Cedergren A., Mattsson P. Influence of dietary factors on aluminium absorption and retention in the brain and bone of rats. Acta Pharmacol. Toxicol. 1985; 56: 331
  • Slanina P., Freeh W., Ekstrdm L-G., Lööf L., Slorach S., Cedergren A. Dietary citric acid enhances absorption of aluminum in antacids. Clin. Chem. 1986; 32: 539
  • Weberg R., Berstad A. Gastrointestinal absorption of aluminium from single doses of aluminium containing antacids in man. Eur. J. Clin. Invest. 1986; 16: 428
  • Brown S., Savory J., Wills M. R. Absorption of aluminum from either citrate or chloride in rat everted gut sacs. Clin. Chem. 1987; 33: 933
  • Martin R. B. Citrate binding of Al3+and Fe3+. J. Inorg. Biochem. 1986; 28: 181
  • van der Voet G. B., de Wolff F. A. Intestinal absorption of aluminum in rats: effect of intraluminal pH and aluminum concentration. J. Appl. Toxicol. 1986; 6: 37
  • Gorsky J. E., Dietz A. A., Spencer H., Osis D. Metabolic balance of aluminum studied in six men. Clin. Chem. 1979; 25: 1739
  • Greger J. L., Baier M. J. Excretion and retention of low or moderate levels of aluminium by human subjects. Food Chem. Toxicol. 1983; 21: 473
  • Feinroth M., Feinroth M. V., Berlyne G. M. Aluminum absorption in the rat everted gut sac. Miner. Electrolyte Metab. 1982; 8: 29
  • van der Voet G. B., de Wolff F. A. A method of studying the intestinal absorption of aluminium in the rat. Arch. Toxicol. 1984; 55: 168
  • Finch C. A., Huebers H. Perspectives in iron metabolism. N. Engl. J. Med. 1982; 306: 1520
  • Manis J. G., Schachter D. Active transport of iron by intestine: features of the two-step mechanism. Am. J. Physiol. 1962; 203: 73
  • Cannata J. B., Suarez C. S., Cuesta V., Roza R. R., Allende M. T., Herrera J., Llanderal J. P. Gastrointestinal aluminium absorption: is it modulated by the iron-absorptive mechanism?. Proc. Eur. Dial. Transplant Assoc. ERA 1984; 21: 354
  • van der Voet G. B., de Wolff F. A. The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats. Toxicol. Appl. Pharmacol. 1987; 90: 190
  • van der Voet G. B., de Wolff F. A. Intestinal absorption of aluminium in rats: effect of sodium, mechanisms and models in toxicology. Arch. Toxicol. Suppl. 1987; 11: 231
  • Provan S. D., Yokel R. A. Influence of calcium on aluminum accumulation by the rat jejunal slice. Res. Commun. Chem. Pathol. Pharmacol. 1988; 59: 79
  • Wills M. R. Intestinal absorption of calcium. Lancet 1973; 1: 820
  • Anthony J., Fadl S., Mason C, Davison A., Berry J. Absorption, deposition and distribution of dietary aluminum in immature rats: effects of dietary vitamin D3and food-borne chelating agents. J. Environ. Sci. Health 1986; B21: 191
  • Chan J. C. M., Jacob M., Brown S., Savory J., Witts M. R. Aluminum metabolism in rats: effects of vitamin D, dihydrotachysterol, 1, 25-dihydroxyvitamin D and phosphate binders. Nephron 1988; 48: 61
  • Henry H. L., Norman A. W. Interactions between aluminum and the actions and metabolism of vitamin D3in the chick. Calcif. Tissue Int. 1985; 37: 484
  • Santos F., Chan J. C. M., Yang M. S., Savory J., Wills M. R. Aluminum deposition in the central nervous system. Preferential accumulation in the hippocampus in weanling rats. Med. Biol. 1987; 65: 53
  • Demontis R., Leflon A., Fournier A., Tahiri Y., Herve M., Moriniere P., Abdull-Massih Z., Atik H., Belbrik S., Renaud H., Plaquet R. 1α(OH) vitamin D3increases plasma aluminum in hemodialyzed patients taking Al(OH)3. Clin. Nephrol. 1986; 26: 146
  • Burnatowska-Hledin M. A., Doyle T. M., Eadie M. J., Mayor G. H. 1, 25-dihydroxyvitamin D3increases serum and tissue accumulation of aluminum in rats. J. Lab. Clin. Med. 1986; 108: 96
  • Adler A. J., Berlyne G. M. Duodenal aluminum absorption in the rat: effect of vitamin D. Am. J. Physiol. 1985; 249: G209
  • Adler A. J., Lee J., Berlyne G. M. Aluminum binding activity in canine duodenal mucosal extracts. Biomed. Pharmacother. 1986; 40: 269
  • Adler A. J., Lee J., Berlyne G. M. Aluminum-binding protein in bovine duodenal extracts. Kidney Int. 1986; 29: 154
  • Wasserman R. H., Fullmer C. S. Vitamin D-induced calcium-binding protein. Calcium and Cell Function, W. Y. Cheung. Academic Press, New York 1982; Vol. 2: 175
  • Clarkson E. M., Luck V. A., Hynson W. V., Bailey R. R., Eastwood J. B., Woodhead J. S., Clements V. R., O'Riordan J. L. H., De Wardener H. E. The effect of aluminium hydroxide on calcium, phosphorus and aluminium balances, the serum parathyroid horomone concentration and the aluminium content of bone in patients with chronic renal failure. Clin. Sci. 1972; 43: 519
  • Cam J. M., Luck V. A., Eastwood J. B., de Wardener H. E. The effect of aluminium hydroxide orally on calcium, phosphorus and aluminium metabolism in normal subjects. Clin. Sci. Mol. Med. 1976; 51: 407
  • Ittel T. H., Buddington B., Miller N. L., Alfrey A. C. Enhanced gastrointestinal absorption of aluminum in uremic rats. Kidney Int. 1987; 32: 821
  • Mayor G. H., Sprague S. M., Hourani M. R., Sanchez T. V. Parathyroid hormone-mediated aluminum deposition and egress in the rat. Kidney Int. 1980; 17: 40
  • Mayor G. H., Sprague S. M., Sanchez T. V. Determinants of tissue aluminum concentration. Am. J. Kidney Dis. 1981; 1: 141
  • Mayor G. H., Burnatowska-Hledin M. A. Impaired renal function and aluminum metabolism. Fed. Proc., Fed. Am. Soc. Exp. Biol 1983; 42: 2979
  • Morrissey J., Rothstein M., Mayor G., Slatopolsky E. Suppression of parathyroid hormone secretion by aluminum. Kidney Int. 1983; 23: 699
  • Wills M. R., Wortsman J., Pak C. Y.C., Bartter F. C. The role of parathyroid hormone in the gastro-intestinal absorption of calcium. Clin. Sci. 1970; 39: 89
  • Alfrey A.C., Sedman A., Chan Y-L. The compartmentalization and metabolism of aluminum in uremic rats. J. Lab. Clin. Med. 1985; 105: 227
  • De Vemejoul M. C., Marchais S., London G., Morieux C, Bielakoff J., Miravet L. Increased bone aluminum deposition after subtotal parathyroidectomy in dialyzed patients. Kidney lnt. 1985; 27: 785
  • Hirschberg R., Herrath D., von Voss R., Bossaller W., Mauelshagen V., Pauls A., Schaefer K. Organ distribution of aluminum in uremic rats: influence of parathyroid hormone and 1, 25-dihydroxy-vitamin D3. Miner. Electrolyte Metab. 1985; 11: 106
  • Lundin A. P., Caruso C, Sass M., Berlyne G. M. Ultrafilterable aluminum in serum of normal man. Clin. Res. 1978; 26: 636A
  • Gidden H., Holland F. F., Klein E. Trace metal protein binding in normal and dialyzed uremic serum. Trans. Am. Soc. Artif. Intern. Organs 1980; 26: 133
  • Kovalchik M. T., Kaehny W. D., Hegg A. P., Jackson J. T., Alfrey A. C. Aluminum Icinetics during hemodialysis. J. Lab. Clin. Med. 1978; 92: 712
  • King S. W., Savory J., Wills M. R. Serum binding of aluminum. Res. Commun. Chem. Pathol. Pharmacol. 1979; 26: 161
  • King S. W., Wills M. R., Savory J. Aluminum distribution in serum following hemodialysis. Ann. Clin. Lab. Sci. 1982; 12: 143
  • Gupta S. K., Waters D. H., Gwilt P. R. Absorption and disposition of aluminum in the rat. J. Pharm. Sci. 1986; 75: 586
  • van der Voet G. B., De Wolff F. A. Distribution of aluminium between plasma and erythrocytes. Hum. Toxicol. 1985; 4: 643
  • Wills M. R., Brown C. S., Bertholf R. L., Ross R., Savory J. Serum and lymphocyte, aluminum and nickel in chronic renal failure. Clin. Chim. Acta 1985; 145: 193
  • Bertholf R. L., Wills M. R., Savory J. Evaluation of equilibrium gel filtration chromatography for the study of protein binding of aluminum in normal and uremic sera. Clin. Physiol. Biochem. 1985; 3: 271
  • Trapp G. A. Plasma aluminum is bound to transferrin. Life Sci. 1983; 33: 311
  • Cochran M., Neon S., Stephens E. Aluminum interaction with67Ga uptake by human plasma and transferrin. Clin. Chim. Acta 1983; 132: 199
  • Bertholf R. L., Wills M. R., Savory J. Quantitative study of aluminum binding to human serum albumin and transferrin by a chelex competitive binding assay. Biochem. Biophys. Res. Commun. 1984; 125: 1020
  • Reuben J. Gadolinium (III) as a paramagnetic probe for proton relaxation studies of biological macro-molecules. Binding to bovine serum albumin. Biochemistry 1971; 10: 2834
  • Martin R. B., Savory J., Brown S., Bertholf R. L., Wills M. R. Transferrin binding of Al3+and Fe3+. Clin. Chem. 1987; 33: 405
  • Gelb M. H., Harris D. C. Correlation of proton release and ultraviolet difference spectra associated with metal binding by transferrin. Arch. Biochem. Biophys. 1980; 200: 93
  • Fishman J. B., Rubin J. B., Handrahan J. V., Connor J. R., Fine R. E. Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J. Neurosci. Res. 1987; 18: 299
  • Bloch B., Popovici T., Levin M. J., Tuil D., Kahn A. Transferrin gene expression visualized in oligodendrocytes of the rat brain by usingin situhybridization and immunohistochemistry. Proc. Natl. Acad. Sci. U. S. A. 1985; 82: 6706
  • Fleming J., Joshi J. G. Ferritin: isolation of aluminum-ferritin complex from brain. Proc. Natl. Acad. Sci. U. S. A. 1987; 84: 7866
  • Betts C. T. Aluminum Poisoning. Research Publishing Company, Toledo, Ohio 1926
  • Campbell I. R., Cass J. R., Cholak J., Kehoe R. A. Aluminum in the environment of man. AMA Arch. Ind. Health 1957; 15: 359
  • Sjögren B., Lundberg I., Lidums V. Aluminium in the blood and urine of industrially exposed workers. Br. J. Ind. Health 1983; 40: 301
  • Mussi I., Calzaferri G., Buratti M., Alessio L. Behaviour of plasma and urinary aluminium levels in occupationally exposed subjects. Int. Arch. Occup. Environ. Health 1984; 54: 155
  • Sjögren B., Elinder C. -G., Lidums V., Chang G. Uptake and urinary excretion of aluminum among welders. Int. Arch. Occup. Environ. Health 1988; 60: 77
  • McLaughlin A. I. G., Kazantzis G., King E., Teare D., Porter R. J., Owen R. Pulmonary fibrosis and encephalopathy associated with the inhalation of aluminium dust. Br. J. Ind. Med. 1962; 19: 253
  • De Vuyst P., Dumortier P., Schandene L., Estenne M., Verhest A., Yernault J. C. Sarcoidlike lung granulomatosis induced by aluminum dusts. Am. Rev. Respir. Dis. 1987; 135: 493
  • Herbert A., Sterling G., Abraham J., Corrin B. Desquamative interstitial pneumonia in an aluminum welder. Hum. Pathol. 1982; 13: 694
  • Andersen A., Dahlberg B. E., Magnus K., Wannag A. Risk of cancer in the Norwegian aluminium industry. Int. J. Cancer 1982; 29: 295
  • Rockette H. E., Arena V. C. Mortality studies of aluminum reduction plant workers: potroom and carbon department. J. Occup. Med. 1983; 25: 549
  • Perl D. P., Gajdusek D. C., Garruto R. M., Yanagihara R. T., Gibbs C. J., Jr. Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Science 1982; 217: 1053
  • Linton R. W., Bryan S. R., Griffis D. P., Shelburne J. D., Fiori C. E., Garruto R. M. Digital imaging studies of aluminum and calcium in neurofibrillary tangle-bearing neurons using secondary ion mass spectrometry. Trace Elements Med. 1987; 4: 99
  • Garruto R. M., Fukatsu R., Yanagihara R., Gajdusek D. C., Hook G., Fiori C. E. Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. Proc. Natl. Acad. Sci. U. S. A. 1984; 81: 1875
  • Garruto R. M., Swyt C, Yanagihara R., Fiori C. E., Gajdusek D. C. Intraneuronal colocalization of silicon with calcium and aluminum in amyotrophic lateral sclerosis and parkinsonism with dementia of Guam. N. Engl. J. Med. 1986; 315: 711
  • Spencer P. S., Nunn P. B., Hugon J., Ludolph A. C., Ross S. M., Roy D. N., Robertson R. C. Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin. Science 1987; 237: 517
  • Spencer P. S., Ohta M., Palmer V. S. Cycad use and motor neurone disease in Kii peninsula of Japan. Lancet 1987; 2: 1462
  • Wurtman R. J. Alzheimer's disease. Sci. Am. 1985; 252: 62
  • Katzman R. Alzheimer's disease. N. Engl. J. Med. 1986; 314: 964
  • Kwentus J. A., Hart R., Lingon N., Taylor J., Silverman J. J. Alzheimer's disease. Am. J. Med. 1986; 81: 91
  • Krishnan S. S., Harrison J. E., Crapper McLachlan D. R. Origin and resolution of the aluminum controversy concerning Alzheimer's neurofibrillary degeneration. Biol. Trace Element Res. 1987; 13: 35
  • Krishnan S. S., McLachlan D. R., Krishnan B., Fenton S. S., Harrison J. E. Aluminum toxicity to the brain. Sci. Total Environ. 1988; 71: 59
  • Crapper McLachlan D. R., Van Berkum M. F. A. Aluminum: a role in degenerative brain disease associated with neurofibrillary degeneration. Progress in Brain Research, D. F. Swaab, E. Fliers, M. Mirmiran, W. A. Van Gool, F. Van Haaren. Elsevier, New York 1986; Vol. 70: 339
  • Perl D. P., Brody A. R. Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science 1980; 208: 297
  • Perl D. P., Pendlebury W. W. Aluminum (A1) accumulation in neurofibrillary tangle (NFT) bearing neurons of senile dementia Alzheimer's type (SDAT)-detection by intraneuronal X-ray spectrometry studies of unstained tissue sections. J. Neuropathol. Exp. Pathol. 1984; 43: 349
  • Perl D. P., Good P. F. The association of aluminum, Alzheimer's disease, and neurofibrillary tangles. J. Neural Transm. 1987; 24((Suppl.))205
  • Candy J. M., Oakley A. E., Klinowski J., Carpenter T. A., Perry R. H., Atack J. R., Perry E. K., Blessed G., Fairbairn A., Edwardson J. A. Aluminosilicates and senile plaque formation in Alzheimer's disease. Lancet 1986; 1: 354
  • Birchall J. D., Chappell J. S. The chemistry of aluminum and silicon in relation to Alzheimer's disease. Clin. Chem. 1988; 34: 265
  • Candy J. M., Oakley A. E., Watt F., Grime G. W., Klinowski J., Perry R. H., Edwardson J. A. A role for aluminum, silicon and iron in the genesis of senile plaques. Modern Trends in Aging Research Colloque INSERM-EURAGE. John Libbey Eurotext, London 1986; Vol. 147: 443
  • Shore D., Wyatt R. J. Aluminum and Alzheimer's disease. J. Nerv. Mem. Dis. 1983; 171: 553
  • Kobayashi S., Hirota N., Saito K., Utsuyama M. Aluminum accumulation in tangle-bearing neurons of Alzheimer's disease withe Balint's syndrome in a long-term aluminum refiner. Acta Neuropathol. 1987; 74: 47
  • Shore D., King S. W., Kaye W., Torrey E. F., Winfrey H. J., Potkin S. G., Weinberger D. R., Savory J., Wills M. R., Wyatt R. J. Serum and cerebrospinal fluid aluminum and circulating parathyroid hormone in primary degenerative (senile) dementia. Neurotoxicology 1980; 1: 55
  • Berlyne G. M., Ben-Ari J., Pest D., Weinberger J., Stern M., Gilmore G. R., Levine R. Hyperaluminaemia from aluminium resins in renal failure. Lancet 1970; 2: 494
  • Berlyne G. M., Yagil R., Ben Ari J., Weinberger G., Knopf E., Danovitch G. M. Aluminium toxicity in rats. Lancet 1972; 1: 564
  • Weinberger G., Yagil R., Popliker F., Berlyne G. M. Alununum metabolism including renal handling in man and animals. Uremia, R. Kluthe, G. Berlyne, B. Burton. George Thieme, Verlag, Stuttgart 1972; 128
  • Alfrey A.C., Mishell J. M., Burks J., Contiguglia S. R., Rudolph H., Lewin E., Holmes J. H. Syndrome of dyspraxia and multifocal seizures associated with chronic hemodialysis. Trans. Am. Soc. Artif. Intern. Organs 1972; 18: 257
  • Alfrey A.C., LeGendre G. R., Kaehny W. D. The dialysis encephalopathy syndrome. Possible aluminum intoxication. N. Engl. J. Med. 1976; 294: 184
  • Alfrey A.C., Hegg A., Craswell P. Metabolism and toxicity of aluminum in renal failure. Am. J. Clin. Nutr. 1980; 33: 1509
  • Sideman S., Manor D. The dialysis dementia syndrome and aluminum intoxication. Nephron 1982; 31: 1
  • McKinney T. D., Basinger M., Dawson E., Jones M. M. Serum aluminum levels in dialysis dementia. Nephron 1982; 32: 53
  • Davison A. M., Walker G. S., Oli H., Lewins A. M. Water supply aluminium concentration, dialysis dementia, and effect of reverse-osmosis water treatment. Lancet 1982; 2: 785
  • Alfrey A. C. Aluminum intoxication. N. Engl. J. Med. 1984; 310: 1113
  • Committee on Nutrition. Aluminum toxicity in infants and children. Pediatrics 1986; 78: 1150
  • Starkey B. J. Aluminium in renal disease: current knowledge and future developments. Ann. Clin. Biochem. 1987; 24: 337
  • Burks J. S., Alfrey A. C., Huddlestone J., Norenberg M. D., Lewin E. A fatal encephalopathy in chronic haemodialysis patients. Lancet 1976; 1: 764
  • Schreeder M. T., Favero M. S., Hughes J. R., Petersen N. J., Bennett P. H., Maynard J. E. Dialysis encephalopathy and aluminum exposure: an epidemiologic analysis. J. Chronic Dis. 1983; 36: 581
  • Cutrufo C, Caroli S., Ben Femmine P., Ortolani E., Palazzesi S., Violante N., Zapponi G. A., Loizzo A. Experimental aluminium encephalopathy: quantitative EEG analysis of aluminium bioavailability. J. Neurol. Neurosurg. Psychiatry 1984; 47: 204
  • Banks W. A., Kastin A. J. Aluminum alters the permeability of the blood-brain barrier to some non-peptides. Neuropharmacology 1985; 24: 407
  • Wills M. R. Metabolic Consequences of Chronic Renal Failure,2nd ed. Harvey Miller and Medcalf, England 1978
  • Wills M. R. Uremic toxins and their effect on intermediary metabolism. Clin. Chem. 1985; 31: 5
  • Boegman R. J., Bates L. A. Neurotoxicity of aluminum. Can. J. Physiol. Pharmacol. 1984; 62: 1010
  • Siegel N., Haug A. Aluminum interaction with calmodulin. Evidence for altered structure and function from optical and enzymatic studies. Biochem. Biophys. Acta 1983; 744: 36
  • Koenig M. L., Jope R. S. Aluminum inhibits the fast phase of voltage-dependent calcium influx into synaptosomes. J. Neurochem. 1987; 49: 316
  • Leeming R. J., Blair J. A. Dialysis dementia, aluminium, and tetrahydrobiopterin metabolism. Lancet 1979; 1: 556
  • Altmann P., Al-Salihi F., Butter K., Cutler P., Blair J., Leeming R., Cunningham J., Marsh F. Serum aluminum levels and erythrocyte dihydropteridine reductase activity in patients on hemodialysis. N. Engl. J. Med. 1987; 317: 80
  • Cutler P., Blair J. A. The effect of lead and aluminum on rat dihydropteridine reductase, mechanisms and models in toxicology. Arch. Toxicol. 1987; 11(Suppl.)227
  • Sprague S. M., Umans J. G. Aluminum and dihydropteridine reductase in dialysis patients. N. Engl. J. Med. 1987; 317: 1604
  • Milstien S., Kaufman S. Aluminum and dihydropteridine reductase in dialysis patients. N. Engl. J. Med. 1987; 317: 1605
  • Wardle E. N. Aluminum and dihydropteridine reductase in dialysis patients. N. Engl. J. Med. 1987; 317: 1605
  • Altmann P., Cunningham J., Blair J., Marsh F. Aluminum and dihydropteridine reductase in dialysis patients. N. Engl. J. Med. 1987; 317: 1605
  • Cowburn J. D., Blair J. A. Effect of aluminium onin-vitrotetrahydrobiopterin synthesis in brain preparations. Lancet 1987; 2: 105
  • Marquis J. K. Aluminum neurotoxicity: an experimental perspective. Bull. Environ. Contam. Toxicol. 1982; 29: 43
  • Sweeney V. P., Perry T. L., Price J. D. E., Reeve C. E., Godolphin W. J., Kish S. J. Brain γ-aminobutyric acid deficiency in dialysis encephalopathy. Neurology 1985; 35: 180
  • Perry T. L., Yong V. W., Kish S. J., Ito M., Foulks J. G., Godolphin W. J., Sweeney V. P. Neurochemical abnormalities in brains of renal failure patients treated by repeated hemodialysis. J. Neurochem. 1985; 45: 1043
  • Patocka J., Bajgar J. Aluminium activation and inhibition of human brain acetylcholinesterase. in vitro, lnorg. Chim. Acta 1987; 135: 161
  • King R. G., Sharp J. A., Boura A. L. A. The effects of Al3+, Cd2+, and Mn2+on human erythrocyte choline transport. Biochem. Pharmacol. 1983; 32: 3611
  • Kosik K. S., Bradley W. G., Good P. F., Rasool C. G., Selkoe D. J. Cholinergic function in lumbar aluminum myelopathy. J. Neuropathol. Exp. Neurol. 1983; 42: 365
  • Kosik K. S., McCluskey A. H., Walsh F. X., Selkoe D. J. Axonal transport of cytoskeletal proteins in aluminum toxicity. Aluminum toxicity and axonal transport. Neurochem. Pathol. 1985; 3: 99
  • Hofstetter J. R., Vincent I., Bugiani O., Gbetti B., Richter J. A. Aluminum-induced decreases in choline acetyltransferase, tyrosine hydroxylase, and glutamate decarboxylase in selected regions of rabbit brain. Neurochem. Pathol. 1987; 6: 177
  • Lipman J. J., Colowick S. P., Lawrence P. L., Abumrad N. N. Aluminum induced encephalopathy in the rat. Life Sci. 1988; 42: 863
  • Lai J. C. K., Blass J. P. Inhibition of brain glycolysis by aluminum. J. Neurochem. 1984; 42: 438
  • Cho S., Joshi J. G. Effect of long-term feeding of aluminium chloride on hexokinase and glucose-6-phosphate dehydrogenase in the brain. Toxicology 1988; 48: 61
  • Johnson G. V. W., Jope R. S. Aluminum impairs glucose utilization and cholinergic activity in rat brain. in vitro, Toxicology 1986; 40: 93
  • Johnson G. V. W., Jope R. S. Aluminum alters cyclic AMP and cyclic GMP levels but not presynaptic cholinergic markers in rat brain. in vivo. Brain Res. 1987; 403: 1
  • Bizzi A., Gambetti P. Phosphorylation of neurofilaments is altered in aluminium intoxication. Acta Neuropathol. 1986; 71: 154
  • Macdonald T. L., Humphreys W. G., Martin R. B. Promotion of tubulin assembly by aluminum ion. in vitro, Science 1987; 236: 183
  • Scholtz C. L., Swash M., Gray A., Kogeorgos J., Marsh F. Neurofibrillary neuronal degeneration in dialysis dementia: a feature of aluminum toxicity. Clin. Neuropathol. 1987; 6: 93
  • Fraser C. L., Arieff A. I. Nervous system complications in uremia. Ann. Int. Med. 1988; 109: 143
  • Simpson W., Kerr D. N. S., Hill A. V. L., Siddiqui J. Y. Skeletal changes in patients on regular hemodialysis. Radiology 1973; 107: 313
  • Tatler G. L. V., Baillod R. A., Varghese Z., Young W. B., Farrow S., Wills M. R., Moorhead J. F. Evolution of bone disease over 10 years in 135 patients with terminal renal failure. Br. Med. J. 1973; 4: 315
  • Moorhead J. F., Tatler G. L. V., Baillod R. A., Varghese Z., Wills M. R., Farrow S. C. Effects of age, sex and polycystic disease on progressive bone disease of renal failure. Br. Med. J. 1974; 4: 557
  • Carmichael K. A., Fallon M. D., Dalinka M., Kaplan F. S., Axel L., Haddad J. G. Osteomalacia and osteitis fibrosa in a man ingesting aluminum hydroxide antacid. Am. J. Med. 1984; 76: 1137
  • Baker L. R. I., Ackrill P., Cattell W. R., Stamp T. C. B., Watson L. Iatrogenic osteomalacia and myopathy due to phosphate depletion. Br. Med. J. 1974; 3: 150
  • Mahony J. F., Hayes J. M., Ingham J. P., Posen S. Hypophosphataemic osteomalacia in patients receiving haemodialysis. Br. Med. J. 1976; 2: 142
  • Ahmed K. Y., Varghese Z., Wills M. R., Meinhard E., Skinner R. K., Baillod R. A., Moorhead J. F. Persistent hypophosphataemia and osteomalacia in dialysis patients not on oral phosphate-binders: response to dihydrotachysterol therapy. Lancet 1976; 2: 439
  • Parsons V., Da vies C, Goode C, Ogg C, Siddiqui J. Aluminium in bone from patients with renal failure. Br. Med. J. 1971; 4: 273
  • Varghese Z., Moorhead J. F., Wills M. R. Plasma calcium and magnesium fractions in chronic renal failure patients on maintenance haemodialysis. Lancet 1973; 2: 985
  • Blomfield J., McPherson J., George C. R. P. Active uptake of copper and zinc during haemodialysis. Br. Med. J. 1969; 2: 141
  • Smith G. D., Winney R. J., McLean A., Robson J. S. Aluminium-related osteomalacia: response to reverse osmosis water treatment. Kidney Int. 1987; 32: 96
  • Drueke T. Dialysis osteomalacia and aluminum intoxication. Nephron 1980; 26: 207
  • Kanis J. A. Osteomalacia and chronic renal failure, J. Clin. Pathol. 1981; 34: 1295
  • Hodsman A. B., Sherrard D. J., Alfrey A. C., Ott S., Brickman A. S., Miller N. L., Maloney N. A., Coburn J. W. Bone aluminum and histomorphometric features of renal osteodystrophy. J. Clin. Endocrinol. Metab. 1982; 54: 539
  • Walker G. S., Aaron J. E., Peacock M., Robinson P. J. A., Davison A. M. Dialysate aluminium concentration and renal bone disease. Kidney Int. 1982; 21: 411
  • Robertson J. A., Felsenfeld A. J., Hay good C. C, Wilson P., Clarke C., Llach F. Animal model of aluminum-induced osteomalacia: role of chronic renal failure. Kidney Int. 1983; 23: 327
  • Boyce B. F., Fe U.G.S., Elder H. Y., Junor B. J., Elliot H. L., Beastall G., Fogelman I., Boyle I. T. Hypercalcaemic osteomalacia due to aluminium toxicity. Lancet 1982; 2: 1009
  • Charbon S. A., Chapuy M. C., Traeger J., Meunier P. J. Intoxication des dialyses renaux par l'aluminium: aspects histologiques osseux. Interet de la biopsie osseuse quantitative. Presse Med., 13
  • Sherrard D. J., Ott S. M., Andress D. L. Pseudohyperparathyroidism. Syndrome associated with aluminum intoxication in patients with renal failure. Am. J. Med. 1985; 79: 127
  • Rodriguez M., Felsenfeld A. J., Llach F. The role of aluminum in the development of hypercalcemia in the rat. Kidney Int. 1987; 31: 766
  • Cannata J. B., Briggs J. D., Junor B. J. R., Fell G. S. Aluminium hydroxide intake: real risk of aluminium toxicity. Br. Med. J. 1983; 86: 1937
  • McCarthy J. T., Kurtz S. B., McCall J. T. Elevated bone aluminum content in dialysis patients without osteomalacia. Mayo Clin. Proc. 1985; 60: 315
  • Goodman W. G., Henry D. A., Horst R., Nudelman R. K., Alfrey A. C, Coburn J. W. Parenteral aluminum administration in the dog: II. Induction of osteomalacia and effect on vitamin D metabolism. Kidney Int. 1984; 25: 370
  • Dunstan C. R., Hills E., Norman A. W., Bishop J. E., Mayer E., Wong S. Y. P., Johnson J. R., George C. R. P., Collett P., Kalowski S., Wyndham R., Lawrence J. R., Evans R. A. The pathogenesis of renal osteodystrophy: role of vitamin D, aluminium, parathyroid hormone, calcium and phosphorus. Q. J. Med. 1985; 55: 127
  • Dunstan C. R., Evans R. A., Hills E., Wong S. Y. P., Alfrey A. C. Effect of aluminum and parathyroid hormone on osteoblasts and bone mineralization in chronic renal failure. Calcif. Tissue Int. 1984; 36: 133
  • Sebert J. L., Marie A., Gueris J., Herve M. A., Leflon P., Garabedian M., Smadja A., Fournier A. Assessment of the aluminum overload and of its possible toxicity in asymptomatic uremic patients: evidence for a depressive effect on bone formation. Bone 1985; 6: 373
  • Andress D. L, Maloney N. A., Endres D. B., Sherrard D. J. Aluminum-associated bone disease in chronic renal failure: high prevalence in a long-term dialysis population. J. Bone Miner. Res. 1986; 1: 391
  • Faugere M.C., Arnaia I. O., Ritz E., Malluche H. H. Loss of bone resulting from accumulation of aluminum in bone of patients undergoing dialysis. J. Lab. Clin. Med. 1986; 107: 481
  • Parisien M., Charhon S. A., Arlot M., Mainetti E., Chavassieux P., Chapuy M. C., Meunier P. J. Evidence for a toxic effect of aluminum on osteoblasts: a histomorphometric study in hemodialysis patients with aplastic bone disease. J. Bone Miner. Res. 1988; 3: 259
  • Galceran T., Finch J., Bergfeld M., Coburn J., Martin K., Teitelbaum S., Slatopolsky E. Biological effects of aluminum on normal dogs: studies on the isolated perfused bone. Endocrinology 1987; 121: 406
  • Lieberherr M., Grosse B., Cournot-Witmer G., Herrman-Erlee M. P. M., Balsan S. Aluminum action on mouse bone cell metabolism and response to PTH and l,25(OH)2D3. Kidney Int. 1987; 31: 736
  • Sedman A. B., Alfrey A. C., Miller N. L., Goodman W. G. Tissue and cellular basis for impaired bone formation in aluminum-related osteomalacia in the pig. J. Clin. Invest. 1987; 79: 86
  • Vukicevic S., Krempien B., Stavljenic A. Effects of 1α, 25- and 24R, 25-dihydroxyvitamin D3on aluminum-induced rickets in growing uremic rats. J. Bone Miner. Res. 1987; 2: 533
  • Ikeda K., Matsumoto T., Morita K., Kurokawa K., Ogata E. Inhibition of in vitro mineralization by aluminum in a clonal osteoblastlike cell line, MC3T3-E1. Calcif. Tissue Int. 1986; 39: 319
  • Bachra B. N., Van Harskamp G. A. The effect of polyvalent metal ions on the stability of a buffer system for calcification. in vitro, Calcif. Tissue Res. 1970; 4: 359
  • Thomas W. C., Meyer J. L. Aluminum-induced osteomalacia: an explanation. Am. J. Nephrol. 1984; 4: 201
  • Talwar H. S., Reddi A. H., Menczel J., Thomas W. C., Jr, Meyer J. L. Influence of aluminum on mineralization during matrix-induced bone development. Kidney Int. 1986; 29: 1038
  • Blumenthal N. C., Posner A. S. In vitromodel of aluminum-induced osteomalacia: inhibition of hydroxyapatite formation and growth. Calcif. Tissue Int. 1984; 36: 439
  • Francis M. D. The inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphates. Calcif. Tissue Res. 1969; 3: 151
  • Christoffersen M. R., Christoffersen J. The effect of aluminum on the rate of dissolution of calcium hydroxyapatite-a contribution to the understanding of aluminum-induced bone diseases. Calcif. Tissue Int. 1985; 37: 673
  • Ellis H. A., McCarthy J. H., Herrington J. Bone aluminium in haemodialysed patients and in rats injected with aluminium chloride: relationship to impaired bone mineralisation. J. Clin. Pathol. 1979; 32: 832
  • Cournot-Witmer G., Zingraff J., Plachot J. J., Escaig F., Lefevre R., Boumati P., Bourdeau A., Garabedian M., Galle P., Bourdon R., Drueke T., Balsan S. Aluminum localization in bone from hemodialyzed patients: relationship to matrix mineralization. Kidney Int. 1981; 20: 375
  • Ott S. M., Maloney N. A., Coburn J. W., Alfrey A. C., Sherrard D. J. The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy. N.
  • Ellis H. A. Aluminum induced osteomalacia in patients with chronic renal failure and in animals. Neiren Hochdruckkrankheilein 1983; 12: S198
  • Charhon S. A., Chavassieux P. M., Meunier P. J., Accominotti M. Serum aluminium concentration and aluminium deposits in bone in patients receiving haemodialysis. Br. Med. J. 1985; 290: 1613
  • Faugere M. C., Malluche H. H. Stainable aluminum and not aluminum content reflects bone histology in dialyzed patients. Kidney Int. 1986; 30: 717
  • Gough K. R., Lloyd O. C., Wills M. R. Nutritional osteomalacia. Lancet 1964; 2: 1261
  • Polanska N., Wills M. R. Factors contributing to osteomalacia in the elderly and in the Asian communities in the United Kingdom. J. Hum. Nutr. 1976; 30: 371
  • Long R. G., Wills M. R. Hepatic osteodystrophy. Br. J. Hosp. Med. 1978; 20: 312
  • Long R. G., Skinner R. K., Wills M. R., Sherlock S. Serum-25-hydroxy vitamin-D in untreated parenchymal and cholestatic liver disease. Lancet 1976; 2: 650
  • Skinner R. K., Long R. G., Sherlock S., Wills M. R. 25-hydroxylation of vitamin D in primary biliary cirrhosis. Lancet 1977; 1: 720
  • Long R. G., Varghese Z., Meinhard E. A., Skinner R. K., Wills M. R., Sherlock S. Parenteral 1,25-dihydroxycholecalciferol in hepatic osteomalacia. Br. Med. J. 1978; 1: 75
  • Chan Y.-L., Alfrey A. C., Posen S., Lissner D., Hills E., Dunstan C. R., Evans R. A. Effect of aluminum on normal and uremic rats: tissue distribution, vitamin D metabolites, and quantitative bone histology. Calcif. Tissue Int. 1983; 35: 344
  • Merke J., Lucas P. A., Szabo A., Helbing F., Hugel U., Drueke T., Ritz E. 1,25(OH)2D3receptors and endorgan response in experimental aluminium intoxication. Kidney Int. 1987; 32: 204
  • Quarles L. D., Dennis V. W., Gitelman H. J., Harrelson J. M., Drezner M. K. Aluminum deposition at the osteoid-bone interface. An epiphenomenon of the osteomalacic state in vitamin D-deficient dogs. J. Clin. Invest. 1985; 75: 1441
  • Quarles L. D., Gitelman H. J., Drezner M. K. Induction of de novo bone formation in the beagle: a novel effect of aluminum. J. Clin. Invest. 1988; 81: 1056
  • Hodsman A. B., Anderson C., Leung F. Y. Accelerated accumulation of aluminum by osteoid matrix in vitamin D deficiency. An animal model of aluminum toxicity. Miner. Electrolyte Metab. 1984; 10: 309
  • Malluche H. H., Faugere M-C, Friedler R. M., Matthews C., Fanti P. Calcitriol, parathyroid hormone, and accumulation of aluminum in bone in dogs with renal failure. J. Clin. Invest. 1987; 79: 754
  • Andress D. L., Ott S. M., Maloney N. A., Sherrard D. J. Effect of parathyroidectomy on bone aluminum accumulation in chronic renal failure. N. Engl. J. Med. 1985; 312: 468
  • Goodman W. G. Thyroparathyroidectomy modifies the skeletal response to aluminum loading in the rat. Kidney Int. 1987; 31: 923
  • Goodman W. G., Gilligan J., Horst R. Short-term aluminum administration in the rat. Effects on bone formation and relationships to renal osteomalacia. J. Clin. Invest. 1984; 73: 171
  • Andress D. L., Maloney N. A., Coburn J. W., Endres D. B., Sherrard D. J. Osteomalacia and aplastic bone disease in aluminum-related osteodystrophy. J. Clin. Endocrinol. Metab. 1987; 65: 11
  • Cann C. E., Prussin S. G., Gordan G. S. Aluminum uptake by the parathyroid glands. J. Clin. Endocrinol. Metab. 1979; 49: 543
  • Galle P., Campos H., Guidicelli C. Localisation ultrastructurale de l'alumiriium dans les cellules parathyroidiennes de malades en dialyse chronique. C. R. Acad. Sci. Paris 1983; 296(Serie III)545
  • Galle P., Campos H., Chadenas D. Concentration anormale d'aluminium dans les lysosomes d'un adenome parathyroidien primitif. Ann. Pathol. 1987; 7: 65
  • O'Hare J. A., Murnaghan D. J. Evidence of increased parathyroid activity on discontinuation of high-aluminum dialysate in patients undergoing hemodialysis. Am. J. Med. 1984; 77: 229
  • Lieberherr M., Grosse B., Cournot-Witmer G., Thil C. L., Balsan S. In vitroeffects of aluminum on bone phosphatases: a possible interaction with bPTH and vitamin D3metabolites. Calcif. Tissue Int. 1982; 34: 280
  • Klein G. L., Lee T. C., Bishop J. E., Vaccaro M. L., Jongen M., Kurokawa K., Coburn J. W., Norman A. W. The effects of aluminum loading on the renal response to parathyroid hormone in the vitamin D-replete rat. Biochem. Med. Metab. Biol. 1986; 36: 363
  • Phelps K. R., Vigorita V. J., Bansal M., Einhorn T. A. Histochemical demonstration of iron but not aluminum in a case of dialysis-associated osteomalacia. Am. J. Med. 1988; 84: 775
  • Milman N., Larsen L. Iron absorption in non-dialysed patients with chronic renal failure, in patients on regular hemodialysis, and in renal transplanted patients. Danish Med. Bull. 1977; 24: 108
  • Elliott H. L., Macdougall A. L. Aluminum studies in dialysis encephalopathy. Proc. Eur. Dial. Transplant Assoc. 1978; 15: 157
  • Manzler A. D., Schreiner A. W. Copper-induced acute hemolytic anemia. A new complication of hemodialysis. Ann. Int. Med. 1970; 73: 409
  • Petrie J. J. B., Row P. G. Dialysis anaemia caused by subacute zinc toxicity. Lancet 1977; 1: 1178
  • Carlson D. J., Shapiro F. L. Methemoglobinemia from well water nitrates: a complication of home dialysis. Ann. Int. Med. 1970; 37: 757
  • Orringer E. P., Mattern W. D. Formaldehyde-induced hemolysis during chronic hemodialysis. N. Engl. J. Med. 1976; 294: 1416
  • Yawata Y., Howe R., Jacob H. S. Abnormal red cell metabolism causing hemolysis in uremia. A defect potentiated by tap water hemodialysis. Ann. Int. Med. 1973; 79: 362
  • Eaton J. W., Koplin C. F., SwofTord H. S., Kjellstrand C.-M., Jacob H. S. Chlorinated urban water a cause of dialysis-induced hemolytic anemia. Science 1973; 181: 463
  • Short A. I. K., Winney R. J., Robson J. S. Reversible microcytic hypochromic anaemia in dialysis patients due to aluminium intoxication. Proc. Eur. Dial. Transplant Assoc. 1980; 17: 226
  • O'Hare J. A., Murnaghan D. J. Reversal of aluminum-induced hemodialysis anemia by a low-aluminum dialysate. N. Engl. J. Med. 1982; 306: 654
  • Touam M., Martinez F., Lacour B., Bourdon R., Zingraff J., Di Giulio S., Drueke T. Aluminum-induced, reversible microcytic anemia in chronic renal failure: clinical and experimental studies. Clin. Nephrol. 1983; 19: 295
  • Kaiser L., Schwartz K. A. Aluminum-induced anemia. Am. J. Kidney Dis. 1985; 5: 348
  • Kaiser L., Schwartz K. A., Burnatowska-Hledin M. A., Mayor G. H. Microcytic anemia secondary to intraperitoneal aluminum in normal and uremic rats. Kidney Int. 1984; 26: 269
  • Altmann P., Plowman D., Marsh F., Cunningham J. Aluminium chelation therapy in dialysis patients: evidence for inhibition of haemoglobin synthesis by low levels of aluminium. Lancet 1988; 1: 1012
  • de la Serna F.-J., Praga M., Gilsanz F., Rodicio J.-L., Ruilope L.-M., Alcazar J.-M. Improvement in the erythropoiesis of chronic haemodialysis patients with desferrioxamine. Lancet 1988; 1: 1010
  • Grant A.C., Modi K. B., Rodger R. S.C., Macdougall A. I., Junor B. J. R. Desferrioxamine, anaemia, and haemodialysis. Lancet 1988; 1: 1405
  • Drueke T. B., Basile C. Desferrioxamine, anaemia, and haemodialysis. Lancet 1988; 1: 1406
  • Kaye M. Bone marrow aluminium storage in renal failure. J. Clin. Pathol. 1983; 36: 1288
  • Watrin A., Galle P. Sites d'accumulation de 1'aluminium dans la moelle osseuse: etude par microscopic electronique, microscopie ionique et microanalyse. X, Biol. Cell 1986; 57: 63
  • Rahman H., Skillen A. W., Ward M. K., Channon S. M., Kerr D. N. S. Affinity of the aluminium binding protein. Int. J. Artif. Organs 1986; 9: 93
  • Mladenovic J. Aluminum inhibits erythropoiesis. in vitro, J. Clin. Invest. 1988; 81: 1661
  • Huber C. T., Frieden E. The inhibition of ferroxidase by trivalent and other metal ions. J. Biol. Chem. 1970; 245: 3979
  • Moreb J., Popovtzer M. M., Friedlaender M. M., Komjn A. M., Hershko C. Evaluation of iron status in patients on chronic hemodialysis: relative usefulness of bone marrow hemosiderin, serum ferritin, transferrin saturation, mean corpuscular volume and red cell protoporphyrin. Nephron 1983; 35: 196
  • Buchet J. P., Lauwerys R., Hassoun A., Dratwa M., Wens R., Collart F., Tielemans C. Effect of aluminum on porphyrin metabolism in hemodialyzed patients. Nephron 1987; 46: 360
  • Meredith P. A., Elliott H. L., Campbell B. C., Moore M. R. Changes in serum aluminium, blood zinc, blood lead and erythrocyte γ-aminolaevulinic acid dehydratase activity during haemodialysis. Toxicol. Lett. 1979; 4: 419
  • McGonigle R. J. S., Parsons V. Aluminium-induced anaemia in haemodialysis patients. Nephron 1985; 39: 1
  • Disler P., Day R., Burman N., Blekkenhorst G., Eales L. Treatment of hemodialysis-related porphyria cutanea tarda with plasma exchange. Am. J. Med. 1982; 72: 989
  • Kushelevsky A., Yagil R., Alfasi Z., Berlyne G. M. Uptake of aluminium ion by the liver. Biomedicine 1976; 25: 59
  • Burnatowska-Hledin M., Ebner K. V., Mayor G. H. In vivoand in vitro effects of aluminum treatment on rat liver mitochondrial function. Biol. Trace Element Res. 1986; 10: 235
  • Truchet M., Jeantet A. Y., Petter C. Intervention des noyaux dans la concentration d'aluminium par les hepatocytes de rat. Etude experimentale. C. R. Acad. Sci. Paris 1987; 305((series III))259
  • Stein G., Laske V., Muller A., Braunlich H., Limb W., Fleck C. Aluminium induced damage of the lysosomes in the liver, spleen and kidneys of rats. J. Appl. Toxicol. 1987; 7: 253
  • Muller L., Wilhelm M. Uptake and distribution of aluminium in rat hepatocytes and its effect on enzyme leakage and lactate formation. Toxicology 1987; 44: 203
  • Galle P., Giudicelli C. P., Nebout T., Baglin A., Fries D. Ultrastructural localization of aluminum in hepatocytes of hemodialyzed patients. Ann. Pathol. 1987; 7: 163
  • Albright F., Reifenstein E. C., Jr. The Parathyroid Glands and Metabolic Bone Disease. Williams & Wilkins, Baltimore 1948
  • Parfitt A. M. Soft-tissue calcification in uremia. Arch. Intern. Med. 1969; 124: 544
  • Kate A. I., Hampers C. L., Merrill J. P. Secondary hyperparathyroidism and renal osteodystrophy in chronic renal failure. Analysis of 195 patients, with observations on the effects of chronic dialysis, kidney transplantation and subtotal parathyroidectomy. Medicine 1969; 48: 333
  • Icnunam K., Horie A. Aluminum accumulation in the skin in end-stage renal failure. Nephron 1987; 46: 239
  • Netter P., Kessler M., Gaucher A., Gillet P., Detons S., Bnrnel D., Benoit J., Got C. Aluminium and dialysis arthropathy. Lancet 1988; 1: 886
  • ContigugHa S. R., Alfrey A. C., Miller N. L., Runnells D. E., Le Geros R. Z. Nature of soft tissue calcification in uremia. Kidney, Int. 1973; 4: 229
  • Wills M. R., Bertholf R. L., Savory J. Unpublished data 1988
  • Elliott H. L., Macdougall A. I., Fell G. S. Aluminium toxicity syndrome. Lancet 1978; 1: 1203
  • Roth A., Nogues C, Galle P., Drneke T. Multiorgan aluminium deposits in a chronic haemodialysis patient. Electron microscope and microprobe studies. Virchows Arch. Pathol. Anal. Physiol. 1984; 405: 131
  • Chagnac A., Ben-Bassat M., Weinstein T., Levi J. Effect of long-term aluminum administration on the renal structure of the rat. Nephron 1987; 47: 66
  • Cacini W., Yokel R. A. Accumulation of aluminum by rabbit renal cortex. Res. Commun. Chem. Pathol. Pharmacol. 1988; 59: 93
  • Klein G. L., Heyman M. B., Lee T. C., Miller N. L., Marathe G., Gourley W. K., Alfrey A. C. Aluminum-associated hepatobiliary dysfunction in rats: relationships to dosage and duration of exposure. Pediatr. Res. 1988; 23: 275
  • D'Haese P. C, Van De Vyver F. L., Lamberts L. V., De Broe M. E. Aluminum an uremic toxin. Adv. Exp. Med. Biol. 1987; 223: 89
  • Macdonald T. L., Martin R. B. Aluminum ion in biological systems. Trends Biochem. Sci. 1988; 13: 15
  • Gilli P., Malacarne F., Fagioli F. Is serum aluminium monitoring useful in evaluating aluminium intoxication?. Lancet 1983; 1: 656
  • Cundy T., Kanis J. A. Serum aluminium measurement in renal bone disease. Lancet 1983; 1: 1168
  • Berland Y., Charhon S. A., Olmer M., Meunier P. J. Predictive value of desferoxamine infusion test for bone aluminium deposits in hemodialyzed patients. Nephron 1985; 40: 433
  • Boyce N. W., Holdsworth S. R., Thomson N. M., Atkins R. C. Rapid alterations in plasma aluminium in association with varied oral aluminium intake in dialysis patients. Nephron 1987; 45: 164
  • Simon P., Ang K. S., Tanquerel T., Auain P., Mauras Y. Surcharge tissulaire en aluminium chez les hemodialyses Test a la desferrioxamine. Nouv. Presse Med. 1982; 11: 209
  • Milliner D. S., Nebeker H. G., Ott S. M., Andress D. L., Sherrard D. J., Alfrey A. C., Slatopoisky E. A., Cobnrn J. W. Use of the deferoxamine infusion test in the diagnosis of aluminum-related osteodystrophy. Ann. Int. Med. 1984; 101: 775
  • Seyfert U. T., Didion K., Albert F. W. Aluminium-related bone disease and haemodialysis. Lancet 1987; 2: 456
  • Sprague S. M., Corwin H. L., Wilson R. S., Mayor G. H., Tanner C. M. Encephalopathy in chronic renal failure responsive to deferoxamine therapy. Another manifestation of aluminum neurotoxicity. Arch. Intern. Med. 1986; 146: 2063
  • Malluche H. H., Smith A. J., Abreo K., Fangere M.-C. The use of deferoxamine in the management of aluminum accumulation in bone in patients with renal failure. N. Engl. J. Med. 1984; 311: 140
  • Roodhooft A. M., van De Vyver F. L., D'Haese P. C, van Acker K. J., Visser W. J., De Broe M. E. Aluminum accumulation in children on chronic dialysis: predictive value of serum aluminum levels and desferrioxamine infusion test. Clin. Nephrol. 1987; 28: 125
  • Ackrill P., Ralston A. J., Day J. P., Hodge K. C. Successful removal of aluminium from patient with dialysis encephalopathy. Lancet 1980; 2: 692
  • Arze R. S., Paridnson I. S., Cartlidge N. E. F., Britton P., Ward M. K. Reversal of aluminium dialysis encephalopathy after desferrioxamine treatment. Lancet 1981; 2: 1116
  • Pogglitsch H., Petek W., Wawschinek O., Holzer W. Treatment of early stages of dialysis encephalopathy by aluminium depletion. Lancet 1981; 2: 1344
  • Milne F. J., Sharf B., Bell P., Meyers A. M. The effect of low aluminum water and desferrioxamine on the outcome of dialysis encephalopathy. Clin. Nephrol. 1983; 20: 202
  • Mason J.C., Jones N. F., Hilton P. J. Aluminium in haemofiltration solutions. Lancet 1983; 1: 762
  • Brown D. J., Dawborn J. K., Ham K. N., Xipell J. M. Treatment of dialysis osteomalacia with desferrioxamine. Lancet 1982; 2: 343
  • Andress D. L., Nebeker H. G., Ott S. M., Endres D. B., Alfrey A. C., Slatopolsky E. A., Coburn J. W., Sherrard D. J. Bone histologic response to deferoxamine in aluminum-related bone disease. Kidney Int. 1987; 31: 1344
  • Stummvoll H. K., Graf H., Meisinger V. Effect of desferrioxamine on aluminum kinetics during hemodialysis. Miner. Electrolyte Metab. 1984; 10: 263
  • Melograna J. M., Yokel R. A. Effect of the chelator desferrioxamine on aluminum elimination in rabbits. Res. Commun. Chem. Pathol. Pharmacol. 1983; 40: 497
  • Payton C. D., Junor B. J. R., Fell G. S. Successful treatment of aluminium encephalopathy by intraperitoneal desferrioxamine. Lancet 1984; 1: 1132
  • McCarthy J. T., Kurtz S. B., Mussman G. V. Deferoxamine-enhanced fecal losses of aluminum and iron in a patient undergoing continuous ambulatory peritoneal dialysis. Am. J. Med. 1987; 82: 367
  • Verbeelen D., Smeyers-Verbeke J., Van Hooff I., Van Der Straeten A., De Roy G. The effect of desferrioxamine on concentration and distribution of aluminum in bone. Kidney Int. 1986; 30: 68
  • Molitoris B. A., Alfrey P. S., Miller N. L., Hasbargen J. A., Kaehney W. D., Alfrey A. C., Smith B. J. Efficacy of intramuscular and intraperitoneal deferoxamine for aluminum chelation. Kidney Int. 1987; 31: 986

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