Physiological and Clinical Aspects of Vitamin A and Its Metabolites

References

• Aykroyd W R. Beriberi and other food deficiency diseases in Newfoundland and Labrador. J Hyg 1930; 30: 357–86
   PubMedGoogle Scholar
• McCollum E V., Davis M. The necessity of certain lipins in the diet during growth. J Biol Chem 1913; 15: 167–75
   Google Scholar
• Osborne T B., Mendel L B. Influence of butterfat on growth. J Biol Chem 1913; 16: 423–37
   Google Scholar
• Hume E M. The effect of radiation with the mercury vapour quartz lamp on the growth of rats on a diet deficient in vitamin A. Lancet 1922; ii: 1318–21
   Google Scholar
• Goldblatt H, Zilva S S. The relation between the growth promoting and anti-rachitic functions of certain substances. Lancet 1923; ii: 647–49
   Google Scholar
• Capper N S. The alleged contamination of carotene by vitamin A. The transformation of carotene into vitamin A as shown by the absorption spectrum of rat liver oils. Biochem J 1930; 24: 453–5
   PubMedGoogle Scholar
• Moore T. The absence of the liver oil vitamin A from carotene. The conversion of carotene to vit A in vivo. Biochem J 1930; 24: 692–702
   PubMedGoogle Scholar
• Isler O. Uber die Ester und Ather des synthetischen Vitamins A. Helv Chi Acta 1949; 32: 489–505
   Google Scholar
• Karrer P, Euster C H. Zur Kenntnis des Vitamins A aus Fischtranen. Helv Chi Acta 1931; 14: 1036–1431
   Google Scholar
• Karrer P. Synthese des Dehydrovitamins A. Helv Chi Acta 1933; 16: 557–61
   Google Scholar
• Farrar K R., Hamlet J C., Henbest H B., et al. A polyene series. I. Anhydrovitamin A2. J Chem Soc 1952; 2763–5
   Google Scholar
• Henbest H B., Jones E RH, Owen T C. Elucidation of the structure of vitamin A2 by photosynthesis. Chem and Ind 1951; 49–50
   Web of Science ®Google Scholar
• Marcus R, Coulson A M. Fat soluble vitamins. The pharmacological basis of therapeutics, Gilman A. Goodman, T W. Rail, A S. Nies, et al. Pergamon Press, New York 1990
   Google Scholar
• Goodman D S., Blaner W S. Biosynthesis, absorption and hepatic metabolism of retinol. The retinoids, M B. Spom, A B. Roberts, D S. Goodman. Academic Press, Orlando 1984; Vol 2: 1–39
   Google Scholar
• Goodman D S., Huang H S. Biosynthesis of vitamin A with rat intestinal enzymes. Science 1965; 149: 879–80
   PubMed Web of Science ®Google Scholar
• Gray E L., Morgareidge K, Cawley J D. Intestinal absorption of vitamin A in normal rat. J Nutr 1940; 20: 67–74
   Google Scholar
• Lombardo D, Fauvel J, Guy O. Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. I. Action on carboxyl esters, glycerides and phospholipids. Biochim Biophys Acta 1980; 611(1)136–46
   PubMed Web of Science ®Google Scholar
• Hollander D. Intestinal absorption of vitamins A, E, D, and K. J Lab Clin Med 1981; 97(4)449–62
   PubMed Web of Science ®Google Scholar
• Hollander D, Muralidhara K S. Vitamin Al intestinal absorption in vivo: influence of luminal factors on transport. Am J Physiol 1977; 232(5)E471–7
   Google Scholar
• Hollander D, Ruble P E., Jr. Beta-carotene intestinal absorption: bile, fatty acid, pH, and flow rate effects on transport. Am J Physiol 1978; 235(6)E686–91
   Google Scholar
• Olson J A., Hayaishi D. The enzymatic cleavage of beta-carotene into vitamin A by soluble enzymes of rat liver and intestine. Proc Natl Acad Sci USA, 65(5)1364–70, 165
   Google Scholar
• Lakshmanan M R., Chansang H, Olson J A. Purification and properties of carotene 15,15′-dioxygenase of rabbit intestine. J Lipid Res 1972; 13(4)477–82
   PubMed Web of Science ®Google Scholar
• Fidge N H., Goodman D S. The enzymatic reduction of retinal to retinol in rat intestine. J Biol Chem 1968; 243(16)4372–9
   PubMed Web of Science ®Google Scholar
• Goodman D S., Blomstrand R, Werner B, et al. The intestinal absorption and metabolism of vitamin A and beta-carotene in man. J Clin Invest 1966; 45(10)1615–23
   PubMed Web of Science ®Google Scholar
• Blomstrand R, Werner B. Studies on the intestinal absorption of radioactive beta-carotene and vitamin A in man. Conversion of beta-carotene into vitamin A. Scand J Clin Lab Invest 1967; 19(4)339–45
   PubMed Web of Science ®Google Scholar
• Crain F D., Lotspeich F J., Krause R F. Biosynthesis of retinoic acid by intestinal enzymes of the rat. J Lipid Res 1967; 8(3)249–54
   PubMed Web of Science ®Google Scholar
• Chytil F. Retinoic acid: biochemistry and metabolism. J Am Acad Dermatol 1986; 15: 741–7
   PubMed Web of Science ®Google Scholar
• Friedman H I., Nylund B. Intestinal fat digestion, absorption and transport. A review. Am J Clin Nutr 1980; 33(5)1108–39
   PubMed Web of Science ®Google Scholar
• Jackson R I., Morrisett J D., Gotto A M., Jr. Lipoprotein structure and metabolism. Physiol Rev 1976; 56(2)259–316
   PubMed Web of Science ®Google Scholar
• Green P H., Glickman R M. Intestinal lipoprotein metabolism. J Lipid Res 1981; 22(8)1153–73
   PubMed Web of Science ®Google Scholar
• Sherrill B C., Dietschy J M. Characterization of the sinusoidal transport process responsible for uptake of chylomicrons by the liver. J Biol Chem 1978; 253(6)1859–67
   PubMed Web of Science ®Google Scholar
• Hui D Y., Innerarity T L., Mahley R W. Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors. J Biol Chem 1981; 256(11)5646–55
   PubMed Web of Science ®Google Scholar
• Blomhoff R, Green M, Berg T, et al. Transport and storage of vitamin A. Science 1990; 250: 399–404
   PubMed Web of Science ®Google Scholar
• Olson J A., Gunning D. The storage form of vitamin A in rat liver cells. J Nutr 1983; 113(11)2184–91
   PubMed Web of Science ®Google Scholar
• Futterman S, Andrews J S. Metabolism of the retina. IV. The composition of vitamin A ester synthesized by the retina. J Biol Chem 1964; 239: 81–4
   PubMed Web of Science ®Google Scholar
• Wake K. Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. Int Rev Cytol 1980; 66: 303–53
   PubMedGoogle Scholar
• McLaren D S. The luxus vitamins-A and B12. Am J Clin Nutr 1981; 34(8)1611–6
   PubMed Web of Science ®Google Scholar
• Blomhoff R, Helgerud P, Rasmussen M, et al. In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells. Proc Natl Acad Sci USA 1982; 79(23)7326–30
   PubMed Web of Science ®Google Scholar
• Harrison E H., Smith J E., Goodman D S. Unusual properties of retinyl palmitate hydrolase activity in rat liver. J Lipid Res 1979; 20(6)753–9
   PubMed Web of Science ®Google Scholar
• Blaner W S., Smith J E., Goodman D S. Partial purification and characterization of rat liver retinyl palmitate hydrolase. Fed Proc Fed Am Soc Exp Biol 1981; 40: 1584, (Abstr.)
   Google Scholar
• Fidge N H., Shiratori T, Ganguly J, et al. Pathways of absorption of retinal and retinoic acid in the rat. J Lipid Res 1968; 9(1)103–9
   PubMed Web of Science ®Google Scholar
• Napoli J L., Pramanik B C., Williams J B., et al. Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasma. J Lipid Res 1985; 26: 387
   PubMed Web of Science ®Google Scholar
• De Leenheer A P., Lambert W E., Claeys I. all-trans-Retinoic acid: measurement of reference values in human serum by high performance liquid chromatography. J Lipid Res 1982; 23: 1362
   PubMed Web of Science ®Google Scholar
• Barua A B., Olson J A. Retinoyl beta-glucuronide: an endogenous compound of human blood. Am J Clin Nutr 1986; 43: 481
   PubMed Web of Science ®Google Scholar
• Lee M O., Dockham P, Sladek N. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid. Pharmacologist 1990; 32: 156, (Abstr)
   Google Scholar
• Lee M, Manthey C, Sladek N. Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid. FASEB J 1990; 4: A659, (Abstr)
   Google Scholar
• Frolik C, Roberts A, Tavela T, et al. Isolation and identification of 4-hydroxy- and 4-oxoretinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver. Biochemistry 1979; 18: 2092–7
   PubMed Web of Science ®Google Scholar
• Frolik C, Roller P, Roberts A, et al. In vitro and in vivo metabolism of all-trans and 13-cis retinoic acid in hamsters. J Biol Chem 1980; 255: 8057–62
   PubMed Web of Science ®Google Scholar
• Roberts A, Nichols M, Newton D, et al. In vitro metabolism of retinoic acid in hamster intestine and liver. J Biol Chem 1979; 245: 6296–6302
   Google Scholar
• Roberts A, Lamb L, Sporn M. Metabolism of all-trans-retinoic acid in hamster liver microsomes. Oxidation of 4-hydroxy- to 4-keto-retinoic acid. Arch Biochem Biophys 1980; 199: 374–83
   PubMed Web of Science ®Google Scholar
• Leo M, Iida S, Leiber C. Retinoic acid metabolism by a system reconstituted with cytochrome P-450. Arch Biochem Biophys 1984; 234: 305–12
   PubMed Web of Science ®Google Scholar
• Meyskens F, Goodman G, Alberts D. 13-cis-retinoic acid: pharmacology, toxicology, and clinical applications for the prevention and treatment of human cancer. Crit Rev Oncol Hematol 1987; 3: 75–101
   Web of Science ®Google Scholar
• Orfanos C, Ehlert R, Gollnick H. The retinoids: a review of their clinical pharmacology and therapeutic use. Drugs 1987; 34: 459–503
   PubMed Web of Science ®Google Scholar
• Lasnitzki I. Reversal of methylcholanthrene-induced changed in mouse prostates in vitro by retinoic acid and its analogues. Br J Cancer 1976; 34: 239–48
   PubMed Web of Science ®Google Scholar
• Mahrle G. Retinoids in oncology. Curr Prob Derm 1985; 13: 128–63
   PubMedGoogle Scholar
• Chatterjee M, Banerjee M R. JV-Nitrosodiethylamine-induced nodule-like alveolar lesion and its prevention by a retinoid in BALB/C mouse mammary glands in the whole organ in culture. Carcinogenesis 1982; 3: 801–4
   PubMed Web of Science ®Google Scholar
• Mettlin C, Saxon G, Swanson M. Vitamin A and lung cancer. J Natl Cancer Inst 1979; 62: 1435–8
   PubMed Web of Science ®Google Scholar
• Hirayama T. Diet and cancer. Nutr Cancer 1979; 1: 67–81
   Google Scholar
• Lippman S M., Meyskens F L., Jr. Retinoids for the prevention of cancer. Nutrition and cancer prevention investigating the role of micronutrients, T E. Moon, M S. Micozzi. Marcel Dekker. 1989; 243–71
   Google Scholar
• Rask L, Anundi H, Blohme J, et al. Structural and functional studies of vitamin-A binding proteins. Ann NY Acad Sci 1981; 359: 79–90
   PubMed Web of Science ®Google Scholar
• Raz A, Shiratori T, Goodman D S. Studies on the protein-protein and protein-ligand interactions involved in retinol transport in plasma. J Biol Chem 1970; 245(8)1903–12
   PubMed Web of Science ®Google Scholar
• Peterson P A. Characteristics of a vitamin A-transporting protein complex occurring in human serum. J Biol Chem 1971a; 246(1)34–43
   PubMed Web of Science ®Google Scholar
• Kanai M, Raz A, Goodman D S. Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest 1968; 47(9)2025–44
   PubMed Web of Science ®Google Scholar
• Goodman S G. Plasma retinol-binding protein. The retinoids, M B. Sporn, A B. Roberts, D S. Goodman. Academic Press. 1984; Vol 2: 41–88
   Google Scholar
• Peterson P A. Studies on the interaction between prealbumin, retinol-binding protein and vitamin A. J Biol Chem 1971b; 246(1)44–9
   PubMed Web of Science ®Google Scholar
• van Jaarsveld P P., Edelhoch H, Goodman D S., et al. The interaction of human plasma retinolbinding with prealbumin. J Biol Chem 1973a; 248: 4698–705
   PubMed Web of Science ®Google Scholar
• Ferguson R N., Edelhoch H, Saroff H A., et al. Negative cooperativity in the binding of thyroxine to human serum prealbumin. Preparation of tritium-labelled 8-anilino-l-naphthalenesulfonic acid. Biochemistry 1975; 14(2)282–9
   PubMed Web of Science ®Google Scholar
• Blake C C., Swan I D., Rerat C, et al. An X-ray study of the subunit structure of prealbumin. J MolBiol 1971; 61(1)217–24
   Google Scholar
• Kanda Y, Goodman D S., Canfield R E., et al. The amino acid sequence of human plasma prealbumin. J Biol Chem 1974; 249(21)6796–805
   PubMed Web of Science ®Google Scholar
• Soprano D R., Pickett C B., Smith J E., et al. Biosynthesis of plasma retinol-binding protein in liver as a larger molecular weight precursor. J Biol Chem 1981; 256(16)8256–8
   PubMed Web of Science ®Google Scholar
• Soprano D R., Smith J E., Goodman D S. Effect of retinol status on retinol-binding protein biosynthesis rate and translatable messenger RNA level in rat liver. J Biol Chem 1982; 257(13)7693–7
   PubMed Web of Science ®Google Scholar
• Smith J E., Muto Y, Milch P O., et al. The effects of chylomicron vitamin A on the metabolism of retinol-binding protein in the rat. J Biol Chem 1973; 248(5)1544–9
   PubMed Web of Science ®Google Scholar
• Muto Y, Smith J E., Milch P O., et al. Regulation of retinol-binding protein metabolism by vitamin A status in the rat. J Biol Chem 1972; 247(8)2542–50
   PubMed Web of Science ®Google Scholar
• Smith F R., Goodman D S. The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma. J Clin Invest 1971; 50(11)2426–36
   PubMed Web of Science ®Google Scholar
• Grippo J F., Sherman M I. Retinoid-binding proteins in embryonal carcinoma cells. Methods Enzymol 1990; 190: 148–55
   PubMed Web of Science ®Google Scholar
• Petkovich M, Brand N J., Krust A, et al. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 1987; 330: 444–50
   PubMed Web of Science ®Google Scholar
• Giguere V, Ong E S., Segui P, et al. Identification of a receptor for the morphogen retinoic acid. Nature 1987; 330: 624–9
   PubMed Web of Science ®Google Scholar
• Danielson M, Hinck L, Ringold G M. Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor. Cell 1989; 57: 1131–8
   PubMed Web of Science ®Google Scholar
• Umesono K, Evans R M. Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 1989; 57: 1139–46
   PubMed Web of Science ®Google Scholar
• Brand N J., Petkovich M, Krust A, et al. Identification of a second human retinoic acid receptor. Nature 1988; 332: 850–3
   PubMed Web of Science ®Google Scholar
• Benbrook D, Lernhardt E, Pfahl M. A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature 1988; 333: 669–72
   PubMed Web of Science ®Google Scholar
• Zelent A, Krust A, Petkovich M, et al. Cloning of murine α and ß retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature 1989; 339: 714–21
   PubMed Web of Science ®Google Scholar
• Krust A, Kastner P, Petkovich M, et al. A third human retinoic acid receptor, hRAR-gamma. Proc Natl Acad Sci USA 1989; 86: 5310–4
   PubMed Web of Science ®Google Scholar
• Mangelsdorf D J., Ong E S., Dyck A, et al. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 1990; 345: 224–9
   PubMed Web of Science ®Google Scholar
• Evans R M. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889–95
   PubMed Web of Science ®Google Scholar
• Glass C K., Devary O V., Rosenfeld M G. Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor. Cell 1990; 63: 729–38
   PubMed Web of Science ®Google Scholar
• Yang N, Schule R, Mangelsdorf D J., et al. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor. Proc Natl Acad Sci USA 1991; 88: 3559–63
   PubMed Web of Science ®Google Scholar
• Ptashne M, Gann A AF. Activators and targets. Nature 1990; 346: 329–31
   PubMed Web of Science ®Google Scholar
• Lewin B. Commitment and activation at Pol II promoters: a tail of protein-protein interactions. Cell 1990; 61: 1161–4
   PubMed Web of Science ®Google Scholar
• Yu V C., Delsert C, Anderson B, et al. RXRß: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 1991; 67: 1251–66
   PubMed Web of Science ®Google Scholar
• Mangelsdorf D J., Borgmeyer U, Heyman R A., et al. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 1992; 6: 329–44
   PubMed Web of Science ®Google Scholar
• Kliewer S A., Umesono K, Mangelsdorf D J., et al. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 1992; 355: 446–9
   PubMed Web of Science ®Google Scholar
• Leid M, Kastner P, Lyons R, et al. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 1992; 68: 377–95
   PubMed Web of Science ®Google Scholar
• Zhang X, Hoffmann B, Tran P B-V, et al. Retinoid X receptors is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 1992; 355: 441–6
   PubMed Web of Science ®Google Scholar
• Bugge T H., Pohl J, Lonnoy O, et al. RXRα, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J 1992; 11: 1409–18
   PubMed Web of Science ®Google Scholar
• Marks M S., Hallenbeck P L., Nagata T, et al. H-2RIIBP (RXRß) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J 1992; 11: 1419–35
   PubMed Web of Science ®Google Scholar
• Glass C K., Devary O V., Rosenfeld M G. Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor. Cell 1990; 63: 729–38
   PubMed Web of Science ®Google Scholar
• La Rosa G, Gudas L J. An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation. Proc Natl Acad Sci USA 1988; 85: 329–33
   PubMed Web of Science ®Google Scholar
• Vasios G W., Gold J D., Petkovich M, et al. A retinoic acid-responsive element is present in the 5′ flanking region of the laminin B 1 gene. Proc Natl Acad Sci USA 1989; 86: 9099–103
   PubMed Web of Science ®Google Scholar
• Duester G, Shean M L., McBride M S., et al. Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis. Mol Cell Biol 1991; 11: 1638–46
   PubMed Web of Science ®Google Scholar
• Lucas P C., O'Brien R M., Mitchell J A., et al. A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene. Proc Natl Acad Sci USA 1991; 88: 2184–8
   PubMed Web of Science ®Google Scholar
• Hosler B A., LaRosa G J., Grippo J F., et al. Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. Mol Cell Biol 1989; 9: 5623–9
   PubMed Web of Science ®Google Scholar
• Felli M P., Vacca A, Meco D, et al. Retinoic acid induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif. Mol Cell Biol 1991; 11: 4771–8
   PubMed Web of Science ®Google Scholar
• Reid L. From gradients to axes, from morphogenesis to differentiation. Cell 1990; 63: 875–82
   PubMed Web of Science ®Google Scholar
• Okamoto K, Okazawa H, Okuda A, et al. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 1990; 60: 461–72
   PubMed Web of Science ®Google Scholar
• Giguere V, Shago M, Zirngibl R, et al. Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo. Mol Cell Biol 1990; 10: 2335–40
   PubMed Web of Science ®Google Scholar
• Kastner P, Krust A, Mendelsohn C, et al. Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. Proc Natl Acad Sci USA 1990; 87: 2700–04
   PubMed Web of Science ®Google Scholar
• Leroy P, Krust A, Zelent A, et al. Multiple isoforms of the mouse retinoic acid receptor α are generated by alternative splicing and differential induction by retinoic acid. EMBO J 1991; 10: 59–69
   PubMed Web of Science ®Google Scholar
• Zelent A, Mendelsohn C, Kastner P, et al. Differentially expressed isoforms of the mouse retinoic acid receptor ß are generated by usage of two promoters and alternative splicing. EMBO J 1991; 10: 71–81
   PubMed Web of Science ®Google Scholar
• Crettaz M, Baron A, Siegenthaler G, et al. Ligand specificities of recombinant retinoic acid receptors RARα and RARß. Biochem J 1990; 272: 391–7
   PubMed Web of Science ®Google Scholar
• Husmann M, Lehmann J, Hoffmann B, et al. Antagonism between retinoic acid receptors. Mol Cell Biol 1991; 11: 4097–103
   PubMed Web of Science ®Google Scholar
• Moore T. Effect of vitamin A deficiency in animals: pharmacology and toxicology of vitamin A. The vitamins2nd ed., W H. Sebrell, R S. Harris. Academic Press, New York 1967; 245–94
   Google Scholar
• Peck G L. Retinoids in clinical dermatology. Progress in diseases of the skin, R Fleischmajer. Grune and Stratton, San Francisco 1981; 227–59
   Google Scholar
• Bollag W. Retinoids and cancer. Cancer Chemother Pharmacol 1979; 3: 207–15
   PubMed Web of Science ®Google Scholar
• Harris C C., Kaufman D G., Sporn M B., et al. Histogenesis of squamous metaplasia and squamous cell carcinoma of the respiratory epithelium in an animal model. Cancer Chemother Rep (Part 3) 1973; 4(2)43–54
   Google Scholar
• Nettesheim P, Snyder C, Kim J CS. Vitamin A and the susceptibility of respiratory tract tissues to carcinogenic insult. Environ Health Perspect 1979; 29: 89–93
   PubMed Web of Science ®Google Scholar
• Eccles S. Effects of retinoids on growth and dissemination of malignant tumours: immunological considerations. Biochem Pharmacol 1985; 34: 1599–610
   PubMed Web of Science ®Google Scholar
• Barker B M., Bender D A., Vitamin A. Vitamins in medicine. William Heinemann Medical Books Ltd, London 1980; Vol 2: 211–91
   Google Scholar
• Durston A J., Timmermans J PM, Hage W J., et al. Retinoic acid causes an anterioposterior transformation in the developing central nervous system. Nature 1989; 340: 140–4
   PubMed Web of Science ®Google Scholar
• Maden M. Vitamin A and pattern formation in the regenerating limb. Nature 1982; 295: 672–5
   PubMed Web of Science ®Google Scholar
• Tickel C, Alberts B, Wolpert L, et al. Local application of retinoic acid to the limb bud mimics the action of the polarizing region. Nature 1982; 296: 564–5
   PubMed Web of Science ®Google Scholar
• Thaller C, Eichele G. Identification and spatial distribution of retinoids in the developing chick limb bud. Nature 1987; 327: 625–8
   PubMed Web of Science ®Google Scholar
• Thaller C, Eichele G. Isolation of 3,4-didehydroretinoic acid, a novel morphogenic signal in the chick wing bud. Nature 1990; 345: 815–9
   PubMed Web of Science ®Google Scholar
• Slack J MW. We have a morphogen. Nature 1987; 327: 553–4
   PubMed Web of Science ®Google Scholar
• Wanek N, Gardiner D M., Muneoka K, et al. Conversion by retinoic acid to anterior cells into ZPA cells in the chick wing bud. Nature 1991; 350: 81–3
   PubMed Web of Science ®Google Scholar
• Noji S, Nohno T, Koyama E, et al. Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud. Nature 1991; 350: 83–6
   PubMed Web of Science ®Google Scholar
• Tabin C J. Retinoids, homeoboxes, and growth factors: toward molecular models for limb development. Cell 1991; 66: 199–217
   PubMed Web of Science ®Google Scholar
• Buck J, Ritter G, Dannecker L, et al. Retinol is essential for growth of activated human B cells. J Exp Med 1990; 171: 1613–24
   PubMed Web of Science ®Google Scholar
• Dennert G, Lotan R. Effects of retinoic acid on the immune system. Stimulation of the killer cell induction. Eur J Immunol 1978; 8(1)23–9
   PubMed Web of Science ®Google Scholar
• Seifter E, Rettura G, Levenson S M. Decreased resistance of C3H/HEHA mice to C3HBA tumour transplants: increased resistance due to supplemental vitamin A. J Natl Cancer Inst 1981; 67(2)467–72
   PubMedGoogle Scholar
• Taub R N., Krantz A R., Dresser D W. The effect of localized injection of adjuvant material on the draining of lymph node. I. Histology. Immunology 1970; 18(2)171–86
   PubMed Web of Science ®Google Scholar
• Trechsel U, Evequoz V, Fleisch H. Stimulation of interleukin 1 and 3 production by retinoic acid in vitro. Biochem J 1985; 230: 339–44
   PubMed Web of Science ®Google Scholar
• Dennert G. Immunostimulation by retinoic acid. Retinoids, differentiation and disease, J Nugent, S Clark. Pitman, London 1985; 117–26
   Google Scholar
• Sidell N, Famatiga E, Golub S H. Augmentation of human thymocyte proliferative responses by retinoic acid. Exp Cell Biol 1981; 49(5)239–45
   PubMedGoogle Scholar
• Sidell N, Ramsdell F. Retinoic acid upregulates interleukin-2 receptors on activated human thymocytes. Cell Immunol 1988; 115: 299–309
   PubMed Web of Science ®Google Scholar
• Sidell N, Rieber P, Golub S H. Immunological aspects or retinoids in humans. I. Analysis of retinoic acid enhancement of thymocyte responses to PHA. Cell Immunol 1984; 87: 118–25
   PubMed Web of Science ®Google Scholar
• Prabhala R H., Garewal H S., Hicks M J., et al. The effects of 13-cis-retinoic acid and betacarotene on cellular immunity in humans. Cancer 1991; 67(6)1556–60
   PubMed Web of Science ®Google Scholar
• Prabhala R H. Two different molecular pathways of immunomodulation by retinoids and carotenoids. Diss Abst Int (B) 1990; 50(5)1775b
   Google Scholar
• Jurin M, Tannock I F. Influence of vitamin A on immunological response. Immunology 1972; 23: 283–7
   PubMed Web of Science ®Google Scholar
• Athanassiades T J. Adjuvant treatment of vitamin A palmitate and analogues on cell-mediated immunity. J Natl Cancer Inst 1981; 67(5)1153–6
   PubMedGoogle Scholar
• Spitznagel J K., Allison A C. Mode of action of adjuvants: retinol and other lysosome-labilizing agents as adjuvants. J Immunol 1970; 104(1)119–27
   PubMed Web of Science ®Google Scholar
• Dennert G. Retinoids and the immune system: immunostimulation by vitamin A. The retinoids, M B. Sporn, A B. Roberts, D S. Goodman. Academic Press. 1984; Vol 2: 373–90
   Google Scholar
• Mori S. The changes in the para-ocular glands which follow the administration of diets low in fat-soluble A; with notes of the effect of the same diets on the salivary glands and the mucosa of the larynx and trachea. Bull Johns Hopkins Hosp 1922; 33: 357
   Google Scholar
• Wolbach S B., Howe P R. Tissue changes following deprivation of fat-soluble vitamin A. J Exp Med 1925; 47: 743
   Google Scholar
• Wolbach S B., Howe P R. Epithelial repair in recovery from vitamin A deficiency. J Exp Med 1933; 57: 511
   PubMedGoogle Scholar
• Dowling J E., Wald G. The biological function of vitamin A acid. Proc Natl Acad Sci USA 1960; 46: 587
   PubMed Web of Science ®Google Scholar
• Ganguly J, Jayaram M. Possible systemic mode of action of vitamin A. Regulation of growth and differentiated function in eukaryote cells, G P. Talwar. Raven Press, New York 1975; 287
   Google Scholar
• Boren H G., Pauley J, Wright E C., et al. Cell populations in the hamster tracheal epithelium in relation to vitamin A status. Int J Vitam Nutr Res 1974; 44: 382
   PubMed Web of Science ®Google Scholar
• Lasnitzki I. Hypovitaminosis-A in the mouse prostate gland cultured in chemically defined medium. Exp Cell Res 1962; 28: 40
   Web of Science ®Google Scholar
• Sporn M, Dunlop N, Newton D, et al. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogues (retinoids). Fed Proc 1976; 35: 1332
   PubMedGoogle Scholar
• Lotan R. Effects of vitamin A and its analogues (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 1980; 605: 33
   PubMed Web of Science ®Google Scholar
• Lotan R. Effects of vitamin A and its analogues (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 1980; 605(1)33–91
   PubMed Web of Science ®Google Scholar
• Roberts A B., Sporn M B. Cellular biology and biochemistry of the retinoids. The retinoids, M B. Spom, A B. Roberts, D S. Goodman. Academic Press. 1984; Vol. 1: 209–86
   Google Scholar
• Takigawa M, Ishida H, Takano T, et al. Polyamine and differentiation by parathyroid hormone is a good marker of differentiated chondrocytes. Proc Natl Acad Sci USA 1980; 77(3)1481–5
   PubMed Web of Science ®Google Scholar
• Logan, Takigawa M, Takano T, Suziki F. Restoration by cyclic AMP of the differentiated phenotype of chondrocytes from de-differentiated cells pretreated with retinoids. Mol Cell Biochem 1982; 42(3)145–53
   PubMed Web of Science ®Google Scholar
• , unpublished data
   Google Scholar
• Lotan R, Nicholson G I. Inhibitory effects of retinoic acid or retinyl acetate on the growth of untransformed, transformed and tumour cells in vitro. J Natl Cancer Inst 1977; 59: 1717–22
   PubMed Web of Science ®Google Scholar
• Thein R, Lotan R. Sensitivity of cultured human osteosarcoma and chondrosarcoma cells to retinoic acid. Cancer Res 1982; 42(11)4771–5
   PubMed Web of Science ®Google Scholar
• Marth C, Mayer I, Daxenbichler G. Effect of retinoic acid and 4-hydroxytamoxifen on human breast cancer cell lines. Biochem Pharmacol 1984; 33: 2217–21
   PubMed Web of Science ®Google Scholar
• Traganos F, Higgins P J., Bueti C, et al. Effects of retinoic acid versus dimethylsulfoxide on Friend erythroleukemia cell growth. II. Induction of quiescent nonproliferating cells. J Natl Cancer Inst 1984; 73: 205–18
   PubMed Web of Science ®Google Scholar
• Yen A, Reese S L., Albright K L. Control of cell differentiation during proliferation. II. Myeloid differentiation and cell cycle arrest of HL-60 promyelocytes preceded by nuclear structural changes. Leuk Res 1985; 9: 51–71
   PubMed Web of Science ®Google Scholar
• Craig R W., Frankfurt O S., Sakagami H, et al. Macromelecular and cell effects of different classes of agents inducing the maturation of human myeloblasts leukemia (ML-1) cells. Cancer Res 1984; 44: 2421–9
   PubMed Web of Science ®Google Scholar
• Vitale C, Rakowki I, Raza A. Number of DNA replication cycles completed by HL-60 cells during differentiation induced by 13-cis-retinoic acid (RA). Blood 1986; 68(suppl)194a, (Abstr.)
   Google Scholar
• Green H. Terminal differentiation of cultured human epidermal cells. Cell 1977; 11(2)405–16
   PubMed Web of Science ®Google Scholar
• Breitman T R., Selonick S E., Collins S J. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA 1980; 77: 2936–40
   PubMed Web of Science ®Google Scholar
• Strickland S, Mahdavi V. The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell 1978; 15: 333–43
   Web of Science ®Google Scholar
• Breitman T R., Collins S J., Keene B R. Terminal differentiation of human promyelocytic leukemia cells in primary culture in response to retinoic acid. Blood 1981; 57: 1000
   PubMed Web of Science ®Google Scholar
• Clamon G H., Spom M B., Smith J M., et al. α and ß-retinyl acetate reverse metaplasia of vitamin A deficiency in hamster trachea in organ culture. Nature (London) 1974; 250: 64
   PubMed Web of Science ®Google Scholar
• Sporn M B., Clamon G H., Dunlop N M., et al. Activity of vitamin A analogues in cell cultures of mouse epidermis and organ cultures of hamster trachea. Nature (London) 1975; 253: 47
   PubMed Web of Science ®Google Scholar
• Clark J N., Marchok A C. The effect of vitamin A on cellular differentiation and mucous glycoprotein synthesis in long-term rat tracheal organ cultures. Differentiation 1979; 14: 175
   PubMed Web of Science ®Google Scholar
• Chopra D P. Squamous metaplasia in organ culture of vitamin A-deficient hamster trachea: cytokinetic and ultrastructural alterations. J Natl Cancer Inst 1982; 69: 895
   PubMedGoogle Scholar
• Wong Y, Buck R. An electron microscopic study of metaplasia of the rat tracheal epithelium in vitamin A deficiency. Lab Invest 1971; 24: 55
   PubMed Web of Science ®Google Scholar
• Harris C C., Spom M B., Kaufman D G., et al. Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo(a)pyrene-ferric oxide. J Natl Cancer Inst 1972; 48: 73
   PubMedGoogle Scholar
• Port C D., Baxter D W., Harris C C. Surface morphology of tracheal epithelium in vitamin A deficiency and reversal. Experimental lung cancer carcinogenesis and bioassays, E Karbe, J F. Park. Springer-Verlag, Basel 1974; 257
   Google Scholar
• Douer D, Koeffler H P. Retinoic acid: inhibition of the clonal growth of human myeloid leukemia cells. J Clin Invest 1982; 69: 277–83
   PubMed Web of Science ®Google Scholar
• Collins S J. The HL-60 promyelocytic leukemia cell line: proliferation, differentiation and cellular oncogene expression. Blood 1987; 70(5)1233–44
   PubMed Web of Science ®Google Scholar
• Jones-Villeneuve E MV, McBumey M, Rogers K A., et al. Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells. J Clin Biol 1982; 94: 253–62
   PubMed Web of Science ®Google Scholar
• McBurney M W., Jones-Villeneuve E MV, Edwards M, et al. Controlled differentiation of teratocarcinoma cells in culture. Nature 1982; 299: 165–7
   PubMed Web of Science ®Google Scholar
• Edwards M KS, McBurney M W. The concentration of retinoic acid determines the differentiated cell types formed by a teratocarcinoma cell line. Dev Biol 1983; 98: 187–91
   PubMed Web of Science ®Google Scholar
• Sato M, Hiragun A, Mitsui H. Preadipocytes possess cellular retinoid binding proteins and their differentiation is inhibited by retinoids. Biochem Biophys Res Commun 1980; 95(4)1839–45
   PubMed Web of Science ®Google Scholar
• Murray T, Russell T R. Inhibition of adipose conversion in 3T3-L2 cells by retinoic acid. J Supramol Struct 1980; 13(2)255–66
   PubMedGoogle Scholar
• Hassell J R., Pennypacker J P., Lewis C A. Chondrogenesis and cell proliferation in limb bud cell cultures treated with cytosine arabinoside and vitamin A. Exp Cell Res 1978; 112(2)409–17
   PubMed Web of Science ®Google Scholar
• Pennypacker J P., Lewis C A., Hassell J R. Altered proteoglycan metabolism in mouse limb mesenchyme cell cultures treated with vitamin A. Arch Biochem Biophys 1978; 186(2)351–8
   PubMed Web of Science ®Google Scholar
• Hong W K., Lippman S M., Itri L M., et al. Prevention of second primary tumours with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 1990; 323(12)795–801
   PubMed Web of Science ®Google Scholar
• Moon R C., Itri L M. Retinoids and cancer. The retinoids, M B. Spom, A B. Roberts, D S. Goodman. Academic Press. 1984; Vol. 2: 327–71
   Google Scholar
• Cohen S M., Wittenberg J F., Bryan G T. Effects of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazoly]formamide. Cancer Res 1976; 36: 2334
   PubMed Web of Science ®Google Scholar
• Sporn M B., Squire R A., Brown C C., et al. 13-cis-retinoic acid inhibition of bladder carcinogenesis in the rat. Science 1977; 195: 487
   PubMed Web of Science ®Google Scholar
• Port C D., Sporn M, Kaufmann D G. Prevention of lung cancer in hamsters by 13-cis-retinoic acid. Proc Am Assoc Cancer Res 1975; 16: 21
   Google Scholar
• Stinson S F., Reznik G, Donahoe R. Effect of three retinoids on tracheal carcinogenesis with N-methyl-N-nitrosurea in hamsters. J Natl Cancer Inst 1981; 66: 947–51
   PubMedGoogle Scholar
• Grubbs C J., Becci P J., Moon R C. Characterization of 1-methyl-1-nitrosurea (MNU)-induced tracheal carcinogenesis and the effect of feeding the retinoid N-(4-hydroxyphenyl)retinamide. Proc Am Assoc Cancer Res 1980; 21: 102
   Google Scholar
• Becci P J., Thompson H J., Grubbs C J., et al. Effect of delay in administration of 13-cis-retinoic acid on the inhibition of urinary bladder carcinogenesis in the rat. Cancer Res 1979; 39: 3141
   PubMed Web of Science ®Google Scholar
• Moon R C., Grubbs C J., Sporn M B., et al. Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosurea. Nature 1977; 267: 620–21
   PubMed Web of Science ®Google Scholar
• Murray A E., Verma A K., Froscio M. Effect of carcinogenesis and tumour promoters on epidermal cyclic 3′:5′-monophosphate metabolism. Control mechanisms in cancer, W E. Criss, T Onto, J R. Sabine. Raven Press, New York 1976; 217
   Google Scholar
• Berenblum I A. A speculative review: the possible nature of promoting action and its significance in the understanding of the mechanism of carcinogenesis. Cancer Res 1954; 14: 471
   PubMed Web of Science ®Google Scholar
• Berenblum I, Shubik P. The role of croton oil applications, associated with a single painting of a carcinogen, in tumour induction of the mouse's skin. Br J Cancer 1947; 1: 379
   PubMed Web of Science ®Google Scholar
• Van Duuren B L. Tumour promoting agents in two-stage carcinogenesis. Prog Exp Tumor Res 1969; 11: 31
   PubMed Web of Science ®Google Scholar
• Diamond I, O'Brien T G., Baird W M. Tumour promoters and the mechanisms of tumour promotion. Adv Cancer Res 1980; 32: 1
   PubMedGoogle Scholar
• Boutwell R K. The function and mechanism of promoters of carcinogenesis. Crit Rev Toxicol 1974; 2: 419
   Google Scholar
• Boutwell R K. The biochemistry of preneoplasia in mouse skin. Cancer Res 1976; 36: 2631
   PubMed Web of Science ®Google Scholar
• Boutwell R K. The role of the induction of ornithine decarboxylase activity in tumour promotion. Origins of human cancer: proceedings of the cold spring harbor conference on cell proliferation, Book B, H H. Hiatt, J D. Watson, J A. Winsten. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1977; 773
   Google Scholar
• O'Brien T G. The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis. Cancer Res 1976; 36: 2644
   PubMed Web of Science ®Google Scholar
• O'Brien T G., Simsiman R C., Boutwell R K. Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumour promoting agents. Cancer Res 1975; 35: 1662
   PubMed Web of Science ®Google Scholar
• O'Brien T G., Simsiman R C., Boutwell R K. Induction of the polyamine-biosynthetic enzymes in mouse epidermis and their specificity for tumour promotion. Cancer Res 1975; 35: 2426
   PubMed Web of Science ®Google Scholar
• Rozhin J, Wilson P S., Bull A W., et al. Ornithine decarboxylase activity in the rat and human colon. Cancer Res 1984; 44: 3226
   PubMed Web of Science ®Google Scholar
• Raina A, Janne J. Physiology of the natural polyamines putrescine, spermidine and spermine. Med Biol 1975; 53: 121
   PubMedGoogle Scholar
• Liskamp R MJ, Brothman A R., Arcoleo J P., et al. Cellular uptake and localization of fluorescent derivatives of phorbol ester tumour promoters. Biochem Biophys Res Commun 1985; 131: 920
   PubMed Web of Science ®Google Scholar
• Ashendel C L. The phorbol ester receptor: a phospholipid-regulated protein kinase. Biochim Biophys Acta 1985; 822: 219
   PubMed Web of Science ®Google Scholar
• Blumberg P M. Protein kinase C as the receptor for the phorbol ester tumour promoters: Sixth Rhoads memorial award lecture. Cancer Res 1988; 48: 1
   PubMed Web of Science ®Google Scholar
• Jetten A M., Shirley J E. Action of retinoic acid on the diacylglycerol-induced ornithine decarboxylase activity, reduction of EGF binding and protein kinase C activation in rat tracheal epithelial 2C5 cells. Exp Cell Res 1986; 166: 519
   PubMed Web of Science ®Google Scholar
• Loprinzi C L., Verma A K. Dose and schedule of oral retinoic acid and indomethacin needed to effectively inhibit phorbol ester-induced epidermal ornithine decarboxylase activity. Carcinogenesis 1985; 6: 1958
   Web of Science ®Google Scholar
• Kumar S, de Vellis J, Lowe N J., et al. trans-Retinoic acid inhibits the appearance of two phorbol ester-induced orntihine decarboxylase mRNAs in mouse epidermis. FEBS Lett 1987; 208: 151
   Web of Science ®Google Scholar
• Verma A K. Inhibition of phorbol ester-caused synthesis of mouse epidermal ornithine decarboxylase by retinoic acid. Biochim Biophys Acta 1985; 846: 109
   PubMed Web of Science ®Google Scholar
• Verma A J. Inhibition of both stage I and stage II mouse skin tumour promotion by retinoic acid and the dependence of inhibition of tumour promotion on the duration of retinoic acid treatment. Cancer Res 1987; 47: 5097
   PubMed Web of Science ®Google Scholar
• Shekelle R B., Lepper M, Liu S, et al. Dietary vitamin A and risk of cancer in the Western Electric study. Lancet 1981; 1185–9
   PubMed Web of Science ®Google Scholar
• Wald N, Idle M, Boreham J, et al. Low serum vitamin A and subsequent risk of cancer. Preliminary results of a prospective study. Lancet 1980; 813–5
   PubMed Web of Science ®Google Scholar
• Kark J D., Smith A H., Switzer B R., et al. Serum vitamin A (retinol) and cancer incidence in Evans County, Georgia. J Natl Cancer Inst 1981; 66(1)7–16
   PubMedGoogle Scholar
• Nomura A MY, Stemmermann G N., Heilbrun L K., et al. Serum vitamin levels and the risk of cancer of specific sites in men of Japanese ancestry in Hawaii. Cancer Res 1985; 45: 2369–72
   PubMed Web of Science ®Google Scholar
• Byers T, Vena J, Mettlin C, et al. Dietary vitamin A and lung cancer risk: an analysis by histologic subtypes. Am J Epidemiol 1984; 120(5)759–76
   PubMed Web of Science ®Google Scholar
• Hinds M W., Kolonel L N., Hankin J H., et al. Dietary vitamin A, carotene, vitamin C and risk of lung cancer in Hawaii. Am J Epidemiol 1984; 119(2)227–37
   PubMed Web of Science ®Google Scholar
• Bjelke E. Dietary vitamin A and human lung cancer. Int J Cancer 1975; 15: 561–5
   PubMed Web of Science ®Google Scholar
• Pastorini U. Lung cancer chemoprevention: facts and hopes. Lung Cancer 1991; 7: 133–50
   Google Scholar
• Sestilli M A. Chemoprevention clinical trial. Problems and solutions. NIH Publication. 1985, No. 85–2715
   Google Scholar
• Greenwald P, Sondik E, Lynch B S. Diet and chemoprevention in NCI's research strategy to achieve national cancer control objectives. Annu Rev Public Health 1986; 7: 267–91
   PubMed Web of Science ®Google Scholar
• Mathe G J., Gouveia J, Hercend T, et al. Correlation between precancerous bronchial metaplasia and cigarette consumption, the preliminary results of retinoid treatment. Cancer Detect Prev 1982; 5: 461–6
   PubMedGoogle Scholar
• Saffiotti U, Montesano R, Sellakumar A R., et al. Experimental cancer of the lung. Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumours. Cancer 1967; 20: 857–64
   PubMed Web of Science ®Google Scholar
• Hubert D D., Holiat S M., Smith W E., et al. Inhibition of transplanted carcinomas to mice by retinoids but not by vitamin C. Cancer Treat Rep 1983; 67: 1061–6
   PubMedGoogle Scholar
• Lippman S M., Kessler J F., Meyskens F L. Retinoids as preventative and therapeutic anticancer agents (part II). Cancer Treat Rep 1987; 71: 493–515
   PubMedGoogle Scholar
• Micksche M, Cerm C, Kokern O, et al. Stimulation of immune response in lung cancer patients by vitamin A therapy. Oncology 1977; 34: 234–8
   PubMed Web of Science ®Google Scholar
• Saccomanno G, Moran P G., Schmidt R D. Effects of 13-cis retinoids on pre-malignant and malignant cells of lung origin. Acta Cytol (Baltimore) 1982; 26: 78–85
   PubMed Web of Science ®Google Scholar
• Weber W, Arnold H, Drings P, et al. Etretinate (RO-10–9359, Tigason), CCNU (1-(2-chloroethyl)-3-cyclohexyl-1 -nitrosurea) and bleomycin vs. CCNU and bleomycin in advanced squamous cell carcinoma of the lung. Onkologie 1982; 6: 62–5
   Google Scholar
• Greenspan J S., Goldhaber P. Oral manifestations of disease. Harrison's principles of internal medicine12th Ed., J D. Wilson, E Braunwald, K J. Isselbacher, et al. McGraw-Hill. 1991; 242–9
   Google Scholar
• Koch H F. Biochemical treatment of precancerous oral lesions: the effectiveness of various analogues of retinoic acid. J Maxillofac Surg 1978; 6: 59–63
   PubMed Web of Science ®Google Scholar
• Koch H F. Effect of retinoids on precancerous lesions of oral mucosa. Retinoids, advances in basic research and therapy, C E. Orfanos, et al. Springer-Verlag, Berlin 1981; 307–12
   Google Scholar
• Hong W K., Endicott J, Itri L M., et al. 13-cis-retinoic acid in the treatment of oral leukoplakia. N Engl J Med 1986; 315: 1501–5
   PubMed Web of Science ®Google Scholar
• Lippman S M., Toth B B., Batsakis J G., et al. Low dose 13-cis-retinoic acid (13cRA) maintains remission in oral premalignancy: more effective than ß-carotene in randomized trial. Proceedings of ASCO 1990; 9: 59, (Abstr. 225)
   Google Scholar
• Lippman S, Kessler J, Al-Sarraf M, et al. Treatment of advanced squamous cell carcinoma of the head and neck with isotretinoin: a phase II randomized trial. Invest New Drugs 1988; 6: 51–6
   PubMed Web of Science ®Google Scholar
• Peck G L., Olsen T G., Yoder F W., et al. Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. N Eng J Med 1979; 300(7)329–33
   PubMed Web of Science ®Google Scholar
• Ehmann C W., Voorhees J J. International studies of the efficacy of etretinate in the treatment of psoriasis. J Am Acad Dermatol 1982; 6(4 pt 2 Suppl)692–6
   PubMed Web of Science ®Google Scholar
• Peck G L., Yoder F W. Treatment of lamellar ichthyosis and other keratinising dermatoses with an oral synthetic retinoid. Lancet 1976; 2(7996)117–4
   Web of Science ®Google Scholar
• Melanoma and skin cancer: proceedings of international cancer conference, McCarthy. McGraw-Hill, Sydney 1972; 349–65
   Google Scholar
• Bollag W, Ott F. Vitamin A in benign and malignant epithelial tumours of the skin. Acta Dermatol Venereol 1975, Suppl 74: 163–6
   Google Scholar
• Grupper C H., Berretti B. Cutaneous neoplasia and etretinate. Proceedings of the 13th international congress of chemotherapy, K H. Spitzky, K Karrer. Egermann, Vienna 1983; 24–27
   Google Scholar
• Swanson N A. Skin cancer. Harrison's principles of internal medicine12th Ed., J D. Wilson, E Braunwald, K J. Isselbacher, et al. McGraw-Hill. 1991; 1633–4
   Google Scholar
• Berretti B, Grouper C H., Edelson Y, et al. Aromatic retinoid in the treatment of multiple superficial basal cell carcinoma, arsenic keratoses and keratoacanthoma. Retinoids, advances in basic research and therapy, C E. Ofanos. Springer-Verlag, Berlin 1981; 397–9
   Google Scholar
• Peck G L. Chemoprevention and treatment of skin cancer with retinoids. Cancer Surv 1983; 2: 315–26
   Google Scholar
• Peck G L. Therapy and prevention of skin cancer. Retinoids: new trends in research and therapy, J H. Saurat. Karger, Basel 1985; 345–54
   Google Scholar
• Peck G L., Olsen T G., Butkus D, et al. Treatment of basal cell carcinomas with 13-cis-retinoic acid. Proc Am Assoc Cancer Res 1979; 20: 56
   Google Scholar
• Lippman S, Meyskens F. Treatment of advanced squamous cell carcinoma of the skin with isotretinoin. Ann Intern Med 1987; 107: 499–502
   PubMed Web of Science ®Google Scholar
• Kingston T, Gaskell S, Marks R. The effects of a novel potent oral retinoid (R013–6298) in the treatment of multiple solar keratoses and squamous cell epithelioma. Eur J Cancer 1983; 19: 1201–05
   Web of Science ®Google Scholar
• Lottan R, Lotan D. Inhibition of melanoma cell growth by retinoids. Structure-activity relationship. Chemistry and biology of synthetic retinoids, M I. Dawson, W H. Okamura. CRC Press. 1990; 251–73
   Google Scholar
• Levine N, Meyskens F L., Jr. Topical vitamin-A-acid therapy for cutaneous metastatic melanoma. Lancet 1980; 2: 224–6
   PubMed Web of Science ®Google Scholar
• Cassidy J, Lippman M, Lacroix A, et al. Phase II trial of 13-cis-retinoic acid in metastatic breast cancer and other malignancies. Proc Am Soc Clin Oncol 1981; 22: 441
   Google Scholar
• Rustin G JS, Bagshawe K D. Trial of an aromatic retinoid in patients with solid tumours. Br J Cancer 1982; 45: 304–08
   PubMed Web of Science ®Google Scholar
• Meyskens F L., Gilmartin E, Alberts D S., et al. Activity of isotretinoin against squamous cell cancers and neoplastic lesions. Cancer Treat Rep 1982; 66: 1315–9
   PubMedGoogle Scholar
• Lippman S, Parkinson D, Itri L, et al. 13-cis-Retinoic acid and interferon alpha-2a: effective combination therapy for advanced squamous cell carcinoma of the skin. J Natl Cancer Inst 1992; 84: 235–41
   PubMed Web of Science ®Google Scholar
• Borrow J, Goddard A D., Sheer D, et al. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 1990; 249: 1577–80
   PubMed Web of Science ®Google Scholar
• Alcalay M, Zangrilli D, Pandolfi P P., et al. Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor ot locus. Proc Natl Acad Sci USA 1991; 88: 1977–81
   PubMed Web of Science ®Google Scholar
• Kakizuka A, Miller W H., Jr, Umesono K, et al. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARot with a novel putative transcription factor, PML. Cell 1991; 66: 663–74
   PubMed Web of Science ®Google Scholar
• De The H, Lavau C, Marchio A, et al. The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 1991; 66: 675–84
   PubMed Web of Science ®Google Scholar
• Pendergast A M., Muller A J., Havlik M H., et al. BCR sequences essential for transformation by BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependant manner. Cell 1991; 66: 161–71
   PubMed Web of Science ®Google Scholar
• Huang M, Ye Y, Chen S, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988; 72: 567–72
   PubMed Web of Science ®Google Scholar
• Castaigne S, Chomienne C, Daniel M, et al. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 1990; 76: 1704–09
   PubMed Web of Science ®Google Scholar
• Chomienne C, Ballerini N, Balitrand N, et al. Retinoic acid therapy for promyelocytic leukemia. Lancet 1989; 2: 746–7
   PubMed Web of Science ®Google Scholar
• Warrell R, Frankel S, Miller W, et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N EnglJ Med 1991; 324: 1385–93
   PubMed Web of Science ®Google Scholar