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Research Article

Clostridium difficile Infection

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Pages 203-245 | Published online: 27 Sep 2008

References

  • Bartlett J G. Clostridium difficile: history of its role as an enteric pathogen and the current state of knowledge about the organisms. Clin Infect Dis 1994; 18(Suppl 4))S265–72
  • Konemann E W, Allen S D, Janda W M, et al. Color atlas and textbook of diagnostic microbiology, 4th ed. Lippincott, Philadelphia 1992; 527
  • Brook I. Clostridial infections in children. J Clin Microbiol 1995; 42: 78–82
  • Achong D M, Oates E. Periprosthetic Clostridium difficile hip abscess imaged with In-111 WBCs. Clin Nucl Med 1994; 19: 860–2
  • Stieglbauer K T, Gruber S A, Johnson S. Elevated serum antibody response to toxin A following splenic abscess due to Clostridium difficile. Clin Infect Dis 1995; 20: 160–2
  • Bartlett J G. Gas gangrene (other Clostridium-associated diseases). Principles and practice of infectious diseases, 3rd ed., G L Mandell, R G Douglas, J E Bennett. Churchill Livingstone, New York 1990; 1850–60
  • Feldman R J, Kallich M, Weinstein M P. Bacteremia due to Clostridium difficile: case report and review of extraintestinal C. difficile infections. Clin Infect Dis 1995; 20: 1560–2
  • Mitty R D, LaMont J T. Clostridium difficile colitis: epidemiology, pathophysiology, and treatment. Ml Sinai J Med 1994; 61: 329–35
  • Kelly C P, Pothoulakis C, LaMont J T. Clostridium difficile colitis. N Engl J Med 1994; 330: 257–62
  • Fekety R. Antibiotic-associated colitis. Mandell, Douglas and Bennett's principles and practice of infectious diseases, 4th ed., G L Mandell, J E Bennett, R Dolin. Churchill Livingstone, New York 1995; 978–87
  • Pothoulakis C, LaMont J T. Clostridium difficile colitis and diarrhea. Gastroenterol Clin North Am 1993; 22: 623–37
  • Tabaqchali S, Jumaa P. Diagnosis and management of Clostridium difficile infection. BMJ 1995; 310: 1375–80
  • Jobe B A, Grasley A, Deveney K E, et al. Clostridium difficile colitis: an increasing hospital-acquired illness. Am J Surg 1995; 169: 480–3
  • Caputo G M, Weitekamp M R, Bacon A E, et al. Clostridium difficile infection: a common clinical problem for the general internist. J Gen Intern Med 1994; 9: 528–33
  • Mitty R D, LaMont J T. Clostridium difficile diarrhea: pathogenesis, epidemiology, and treatment. Gastroenterologist 1994; 2: 61–9
  • Skidmore A G. Clostridium difficile—the only important nosocomial gastrointestinal pathogen in developed countries. Can J Infect Control 1993; 8: 33
  • Riley T V, Codde J P, Rouse I L. Increased length of hospital stay due to Clostridium difficile-associated diarrhoea. Lancet 1995; 345: 455–6
  • Gerding D N, Johnson S, Peterson L R, et al. Society for Healthcare Epidemiology of America position paper on Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol 1995; 16: 459–77
  • Sneath P HA, Mair N S, Sharpe M E, et al. Bergey's manual of systematic bacteriology. Williams & Wilkins, Baltimore 1986; Vol 2: 1165–6
  • Onderdonk A B, Allen S D. Clostridium. Manual of clinical microbiology, 6th ed., P R Murray, E J Baron, M A Pfaller, et al. ASM Press, Washington 1995; 574–86
  • O'Neill G, Adams J E, Bowman R A, et al. A molecular characterization of Clostridium difficile isolates from humans, animals and their environments. Epidemiol Infect 1993; 111: 257–64
  • Riley T V. The epidemiology of Clostridium difficile-associated diarrhoea. Rev Med Microbiol 1994; 5: 117–22
  • El-Mohandes A E, Keiser J F, Refat M, et al. Prevalence and toxigenicity of Clostridium difficile isolates in fecal microflora of preterm infants in the intensive care nursery. Biol Neonate 1993; 63: 225–9
  • Wilson K H. The microecology of Clostridium difficile. Clin Infect Dis 1993; 16(Suppl 4))S214–8
  • Yamamoto-Osaki T, Kamiya S, Sawamura S, et al. Growth inhibition of Clostridium difficile by intestinal flora of infant faeces in continuous flow culture. J Med Microbiol 1994; 40: 179–87
  • Nelson D E, Auerbach S B, Baltch A L, et al. Epidemic Clostridium difficile-associated diarrhea: role of second-and third-generation cephalosporins. Infect Control Hosp Epidemiol 1994; 15: 88–94
  • Palmbach W, Heizmann W R, Decker K. Häufigkeit und Bedeutung von Clostridium difficile bei Patientinnen mit antibakterieller Therapie oder perioperativer Cefoxitinprophylaxe. Geburtsh Frauenheilk 1994; 54: 84–8
  • Braegger C P, Nadal D. Clarithromycin and pseudomembranous enterocolitis. Lancet 1994; 343: 241
  • Teare J P, Booth J L, Brown J L, et al. Pseudomembranous colitis following clarithromycin therapy. Eur J Gastroenterol Hepatol 1995; 7: 275–7
  • Gineston J L, Watine J, Bruna T, et al. Colit aigue hémorragique á la pristinamycine: 2 cas avec association de Klebsiella oxytoca et de Clostridium difficile. Gastroenterol Clin Biol 1993; 17: 773–5
  • Gordin F, Gibert C, Schmidt M E. Clostridium difficile colitis associated with trimethoprim-sulfamethoxazole given as prophylaxis for Pneumocystis carinii pneumonia. Am J Med 1994; 96: 94–5
  • Golledge C L, Riley T V. Clostridium difficile-associated diarrhoea after doxycycline malaria prophylaxis. Lancet 1995; 345: 1377–8
  • Anand A, Glatt A E. Clostridium difficile infection associated with antineoplastic chemotherapy: a review. Clin Infect Dis 1993; 17: 109–13
  • Anand A. Clostridium difficile colitis: causes, cures [letter]. JAMA 1993; 269: 2087
  • Chachaty E, Bourneix C, Renard S, et al. Shedding of Clostridium difficile, fecal beta-lactamase activity, and gastrointestinal symptoms in 51 volunteers treated with oral cefixime. Antimicrob Agents Chemother 1993; 37: 1432–5
  • Hardy S P, Bayston R, Spitz L. Prolonged carriage of Clostridium difficile in Hirschsprung's disease. Arch Dis Child 1993; 69: 221–4
  • Burgner D P, Rfidah H, Beattie T J, et al. Clostridium difficile after haemolytic uraemic syndrome. Arch Dis Child 1993; 69: 239–40
  • Eveillard M, Fourel V, Marc M C, et al. Identification and characterization of adhesive factors of Clostridium difficile involved in adhesion to human colonic enterocyte-like Caco-2 and mucus-secreting HT29 cells in culture. Mol Microbiol 1993; 7: 371–81
  • Kaijalainen T, Bare M C, Collignon A, et al. Cloning of genetic determinant from Clostridium difficile involved in adherence to tissue culture cells and mucus. Infect Immun 1994; 62: 4347–55
  • Mulligan M E, Miller S D, McFarland L V, et al. Elevated levels of serum immunoglobulins in asymptomatic carriers of Clostridium difficile. Clin Infect Dis 1993; 16(Suppl 4))S239–44
  • Bacon A E, Fekety R. Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea. Diagn Microbiol infect Dis 1994; 18: 205–9
  • Bongaerts G P, Lyerly D M. Role of toxins A and B in the pathogenesis of Clostridium difficile. Microb Pathog 1994; 17: 1–12
  • Knoop F C, Ownes M, Crocker I C. Clostridium difficile: clinical disease and diagnosis. Clin Microbiol Rev 1993; 6: 251–65
  • Lyerly D M, Krivan H C, Wilkins T D. Clostridium difficile: its disease and toxins. Clin Microbiol Rev 1988; 1: 1–18
  • Olson M M, Shanholtzer C J, Lee J T, Jr, et al. Ten years of prospective Clostridium difficile-associated disease surveillance and treatment at the Minneapolis VA Medical Center, 1982-1991. Infect Control Hosp Epidemiol 1994; 15: 371–81
  • Depitre C, Delmée M, Avesani V, et al. Serogroup F strains of Clostridium difficile produce toxin B but not toxin A. J Med Microbiol 1993; 38: 434–41
  • Guerrant R L. Lessons from diarrheal diseases: demography to molecular pharmacology. J Infect Dis 1994; 169: 1206–18
  • Shoshan M C, Florin I, Thelestam M. Activation of cellular phosphiolipase A2 by Clostridium difficile toxin B. J Cell Biochem 1993; 52: 116–24
  • Murrell W G, Stewart B J, O'Neill C, et al. Enterotoxic bacteria in the sudden infant death syndrome. J Med Microbiol 1993; 39: 114–27
  • Rolfe R D, Song W. Immunoglobulin and non-immunoglobulin components of human milk inhibit Clostridium difficile toxin A-receptor binding. J Med Microbiol 1995; 42: 10–9
  • Collignon A, Ticchi L, Depitre C, et al. Heterogeneity of Clostridium difficile isolates from infants. Eur J Pediatr 1993; 152: 319–22
  • Jensen G L, Brass J E, Bourbeau P P, et al. Risk factors for Clostridium difficile stool cytotoxin B among critically ill patients: role of sucralfate. J Infect Dis 1994; 170: 227–30
  • Knudsen J D, Tvede M. Demonstration of toxin A and B by polymerase chain reaction and McCoy cell assay in clinical isolates of Clostridium difficile from Denmark. APMIS 1993; 101: 18–22
  • Yamakawa K, Kamiya S, Meng X Q. Toxin production by Clostridium difficile in a defined medium with limited amino acids. J Med Microbiol 1994; 41: 319–23
  • Hoppen T, Keller K M, Stolte M. Clostridium difficile bei frühkindlicher Pancolitis ulcerosa. Monatsschr Kinderheilkd 1993; 141: 474–7
  • Wamy M, Vaerman J P, Avesani V, et al. Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection. Infect Immun 1994; 62: 384–9
  • Hirschhorn L R, Trnka Y, Onderdonk A, et al. Epidemiology of community-acquired Clostridium difficile-associated diarrhea. J Infect Dis 1994; 169: 127–33
  • Simor A E, Yake S L, Tsimidis K. Infection due to Clostridium difficile among elderly residents of a long-term care facility. Clin Infect Dis 1993; 17: 672–8
  • Walker K J, Gilliland S S, Vance-Bryan K, et al. Clostridium difficile colonization in residents of long-term care facilities: prevalence and risk factors. JAGS 1993; 41: 940–6
  • Yablon S A, Krotenberg R, Fruhmann K. Clostridium difficile-related disease: evaluation and prevalence among inpatients with diarrhea in two freestanding rehabilitation hospitals. Arch Phys Med Rehabil 1993; 74: 9–13
  • Riley T V, O'Neill G L, Bowman R A, et al. Clostridium difficile-associated diarrhoea: epidemiological data from Western Australia. Epidemiol Infect 1994; 113: 13–20
  • Rudensky B, Rosner S, Sonnenblick M, et al. The prevalence and nosocomial acquisition of Clostridium difficile in elderly hospitalized patients. Postgrad Med J 1993; 69: 45–7
  • Knobel H, Salvadó M, Plass E, et al. Brote epidémico nosocomial de diarrea por Clostridium difficile. Estudio comparativo con la diarrea asociada al uso de antibióticos. Med Clin (Barc) 1994; 102: 165–8
  • Anand A, Bashey B, Mir T, et al. Epidemiology, clinical manifestations, and outcome of Clostridium difficile-associated diarrhea. Am J Castroenterol 1994; 89: 519–23
  • MacDonald K S, McLeod J, Nicolle L. Clostridium difficile enteritis in a Canadian tertiary care hospital. Can J Infect Control 1993; 8: 37–40
  • Samore M H, DeGirolami P C, Tlucko A, et al. Clostridium difficile colonization and diarrhea at a tertiary care hospital. Clin Infect Dis 1994; 18: 181–7
  • Suva J. Clostridium difficile nosocomial infections—still lethal and persistent. Infect Control Hosp Epidemiol 1994; 15: 368–70
  • Rabasa M, Aguado J M, Lizasoain M, et al. Rentabilidad de la detección de toxina de Clostridium difficile frente a coprocultivo para el studio de la diarrea nosocomial. Enferm Infec Microbiol Clin 1993; 11: 479–81
  • Manian F A, Meyer L. CD AD rates [letter]. Infect Control Hosp Epidemiol 1995; 16: 63–5
  • Tumbarello M, Tacconelli E, Leone F, et al. Clostridium difficile-associated diarrhoea in patients with human immunodeficiency virus infection: a case-control study. Eur J Gastroenterol Hepatol 1995; 7: 259–63
  • Nath S K, Thornley J H, Kelly M, et al. A sustained outbreak of Clostridium difficile in a general hospital: persistence of a toxigenic clone in four units. Infect Control Hosp Epidemiol 1994; 15: 382–9
  • Getchell-White S I, Barrett L J, Barton B A, et al. Nosocomial significance of Clostridium difficile: an epidemiologic study using molecular markers. Med Microbiol Lett 1992; 1: 49–55
  • Liesenfeld O, Weinke T, Hahn H. Three-year prevalence of enteropathogenic bacteria in an urban patient population in Germany. Infection 1993; 21: 101–5
  • Hutin Y, Molina J M, Casin I, et al. Risk factors for Clostridium difficile-associated diarrhoea in HIV-infected patients. AIDS 1993; 7: 1441–7
  • McBride M O, Homer P J, Coker R J, et al. Clostridium difficile-associated diarrhoea in HIV-infected patients. AIDS 1994; 8: 557–8
  • Barbut F, Mario N, Meyohas M C, et al. Investigation of a nosocomial outbreak of Clostridium difficile-associated diarrhoea among AIDS patients by random amplified polymorphic DNA (RAPD) assay. J Hosp Infect 1994; 26: 181–9
  • Cappell M S, Philogene C. Clostridium difficile infection is a treatable cause of diarrhea in patients with advanced human immunodeficiency virus infection: a study of seven consecutive patients admitted from 1986 to 1992 to a university teaching hospital. Am J Gastroenterol 1993; 88: 891–7
  • Collignon A, Jeantils V, Cruaud P, et al. Prevalence de Clostridium difficile et de la toxine A dans les selles de patients VIH positifs. Pathol Biol (Paris) 1993; 41: 415–20
  • Cozart J C, Kalangi S S, Clench M H, et al. Clostridium difficile diarrhea in patients with AIDS versus non-AIDS controls. J Clin Gastroenterol 1993; 16: 192–4
  • Lu S S, Schwartz J M, Simon D M, et al. Clostridium difficile-associated diarrhea in patients with HTV positivity and AIDS: a prospective controlled study. Am J Gastroenterol 1994; 89: 1226–9
  • Barbut F, Depitre C, Delmée M, et al. Comparison of enterotoxin production, serogrouping, and antimicrobial susceptibilities of Clostridium difficile strains isolated from AIDS and human immunodeficiency virus-negative patients. J Clin Microbiol 1993; 31: 740–2
  • Vautrin A C, Enck S, Antoniotti G, et al. Enquête a l'aide de trois marqueurs épidémiologiques après 22 diarrhées a Clostridium difficile dans un hôpital gériatrique. Pathol Biol (Paris) 1993; 41: 421–7
  • Magee J T, Brazier J S, Hosein I K, et al. An investigation of a nosocomial outbreak of Clostridium difficile by pyrolysis mass spectrometry. J Med Microbiol 1993; 39: 345–51
  • Martirosian G, Wize J, Sokól-Leszczyñska B, et al. Comparison of Delmée and Polish sero-group specific Clostridium difficile strains. Acta Microbiol Pol 1993; 42: 251–7
  • Delmée M, Depitre C, Corthier G, et al. Use of an enzyme-linked immunoassay for Clostridium difficile serogrouping. J Clin Microbiol 1993; 31: 2526–8
  • Kato H, Cavallaro J J, Kato N, et al. Typing of Clostridium difficile by Western immunoblotting with 10 different antisera. J Clin Microbiol 1993; 31: 413–5
  • Lahn M, Tyler G, Däubener W, et al. Improvement of Clostridium difficile isolation by heat-shock and typing of the isolated strains by SDS-PAGE. Eur J Epidemiol 1993; 9: 327–34
  • Costas M, Holmes B, On S LW, et al. Investigation of an outbreak of Clostridium difficile infection in a general hospital by numerical analysis of protein patterns by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. J Clin Microbiol 1994; 32: 759–65
  • Cartmill T D, Panigrahi H, Worsley M A, et al. Management and control of a large outbreak of diarrhoea due to Clostridium difficile. J Hosp Infect 1994; 27: 1–15
  • Costas M, Holmes B, Ganner M, et al. Identification of outbreak-associated and other strains of Clostridium difficile by numerical analysis of SDS-PAGE protein patterns. Epidemiol Infect 1994; 113: 1–12
  • Clabots C R, Johnson S, Bettin K M, et al. Development of a rapid and efficient restriction endonuclease analysis typing system for Clostridium difficile and correlation with other typing systems. J Clin Microbiol 1993; 31: 1870–5
  • Samore M H, Bettin K M, DeGirolami P C, et al. Wide diversity of Clostridium difficile types at a tertiary referral hospital. J Infect Dis 1994; 170: 615–21
  • Kato H, Kato N, Watanabe K, et al. Application of typing by pulsed-field gel electrophoresis to the study of Clostridium difficile in a neonatal intensive care unit. J Clin Microbiol 1994; 32: 2067–70
  • Kristjánsson M, Samore M H, Gerding D N, et al. Comparison of restriction endonuclease analysis, ribotyping, and pulsed-field gel electrophoresis for molecular differentiation of Clostridium difficile strains. J Clin Microbiol 1994; 32: 1963–9
  • Cartwright C P, Stock F, Beekman S E, et al. PCR amplification of rRNA intergenic spacer regions as a method for epidemiologic typing of Clostridium difficile. J Clin Microbiol 1995; 33: 184–7
  • Gürtler V. Typing of Clostridium difficile strains by PCR amplification of variable length 16S-23S rDNA spacer regions. J Gen Microbiol 1993; 139: 3089–97
  • Wilks M, Tabaqchali S. Typing of Clostridium difficile by polymerase chain reaction with an arbitrary primer. J Hosp Infect 1994; 28: 231–4
  • Suva J, Jr, Tang Y J, Gumerlock P H. Genotyping of Clostridium difficile isolates. J Infect Dis 1994; 169: 661–4
  • Killgore G E, Kato H. Use of arbitrary primer PCR to type Clostridium difficile and comparison of results with those by immunoblot typing. J Clin Microbiol 1994; 32: 1591–3
  • Barbut F, Mario N, Frottier J, et al. Use of arbitrary primer polymerase chain reaction for investigating an outbreak of Clostridium difficile-associated diarrhea in AIDS patients. Eur J Clin Microbiol Infect Dis 1993; 12: 794–5
  • Martirosian G, Kuipers S, Verbrugh H, et al. PCR ribotyping and arbitrarily primed PCR for typing strains of Clostridium difficile from a Polish maternity hospital. J Clin Microbiol 1995; 33: 2016–21
  • Wolfhagen M J, Fluit A C, Torensma R, et al. Comparison of typing methods for Clostridium difficile isolates. J Clin Microbiol 1993; 31: 2208–11
  • Prendergast T M, Marini C P, D'Angelo A J, et al. Surgical patients with pseudomembranous colitis: factors affecting prognosis. Surgery 1994; 116: 768–75
  • McFarland L V, Surawicz C M, Greenberg R N, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994; 271: 1913–8
  • Godet A S, Williams R D. Postoperative Clostridium difficile gastroenteritis. J Urol 1993; 149: 142–4
  • Kochhar R, Ayyagari A, Goenka M K, et al. Role of infectious agents in exacerbations of ulcerative colitis in India. A study of Clostridium difficile. J Clin Gastroenterol 1993; 16: 26–30
  • Chatila W, Manthous C A. Clostridium difficile causing sepsis and an acute abdomen in critically ill patients. Crit Care Med 1995; 23: 1146–50
  • Counihan T C, Roberts P L. Pseudomembranous colitis. Surg Clin North Am 1993; 73: 1063–74
  • Jacobs N F, Jr. Antibiotic-induced diarrhea and pseudomembranous colitis. Postgrad Med 1994; 95: 117–20
  • Tsutaoka B, Hansen J, Johnson D, et al. Antibiotic-associated pseudomembranous enteritis due to Clostridium difficile. Clin Infect Dis 1994; 18: 982–4
  • Franco J, Massey B T, Komorowski R. Cytomegalovirus infection causing pseudomembranous colitis. Am J Gastroenterol 1994; 89: 2246–8
  • Harris P R, Figueroa-Clon R. Rectal prolapse in children associated with Clostridium difficile infection. Pediatr Infect Dis J 1995; 14: 78–80
  • Yaseen Z H, Watson R E, Dean H A, et al. Case report: transverse colon volvulus in a patient with Clostridium difficile pseudomembranous colitis. Am J Med Sci 1994; 308: 247–50
  • Sensini A, Marroni M, Bassotti G, et al. Clostridium difficile-associated reactive arthritis in an HLA-B27 negative male. J Clin Gastroenterol 1993; 16: 354–5
  • Putterman C, Rubinow A. Reactive arthritis associated with Clostridium difficile pseudomembranous colitis. Semin Arthritis Rheum 1993; 22: 420–6
  • Keating R M, Vyas A S. Reactive arthritis following Clostridium difficile colitis. West J Med 1995; 162: 61–3
  • Boice J L. Reactive arthritis induced by Clostridium difficile. West J Med 1994; 160: 171–2
  • Boland G W, Lee M J, Cats A M, et al. Antibiotic-induced diarrhea: specificity of abdominal CT for the diagnosis of Clostridium difficile disease. Radiology 1994; 191: 103–6
  • Boland G W, Lee M J, Cats A M, et al. Clostridium difficile colitis: correlation of CT findings with severity of clinical disease. Clin Radiol 1995; 50: 153–6
  • Burton E M, Mercado-Deane M G, Patel K. Pneumatosis intestinalis in a child with AIDS and pseudomembranous colitis. Pediatr Radiol 1994; 24: 609–10
  • Kuntz D P, Shortsleeve M J, Kantrowitz P A, et al. Clostridium difficile enteritis: a cause of intramural gas. Digest Dis Sci 1993; 38: 1942–4
  • Nathan M A, Seabold J E, Brown B P, et al. Colonic localization of labeled leukocytes in critically ill patients. Scintigraphic detection of pseudomembranous colitis. Clin Nucl Med 1995; 20: 99–106
  • Fekety R, Shah A B. Diagnosis and treatment of Clostridium difficile colitis. JAMA 1993; 269: 71–5
  • Gerding D N, Brazier J S. Optimal methods for identifying Clostridium difficile infections. Clin Infect Dis 1993; 16(Suppl 4))S439–42
  • Lyerly D M. Clostridium difficile testing. Clin Microbiol Newl 1995; 17: 17–22
  • Anglim A M, Fair B M. Nosocomial diarrhea due to Clostridium difficile. Curr Opin Infect Dis 1994; 7: 602–8
  • Pathoulakis C, Castagliuolo I, LaMont J T. Diagnostic tests for Clostridium difficile diarrhoea and colitis: past, present and future. J Gastroenterol Hepatol 1993; 8: 311–2
  • Brazier J S. Role of the laboratory in investigations of Clostridium difficile diarrhea. Clin Infect Dis 1993; 16(Suppl 4))S228–33
  • Peterson L R, Kelly P J. The role of the clinical microbiology laboratory in the management of Clostridium difficile-associated diarrhea. Infect Dis North Am 1993; 7: 277–93
  • Barbut F, Kajzer C, Planas N, et al. Comparison of three enzyme immunoassays, a cytotoxicity assay, and toxigenic culture for diagnosis of Clostridium difficile-associated diarrhea. J Clin Microbiol 1993; 31: 963–7
  • Liesenfeld O, Saeger F, Hahn H. Detection of Clostridium difficile toxin by enzyme immunoassay, tissue culture test and culture. Infection 1994; 22: 29–32
  • Marx C E, Morris A, Wilson M L, et al. Fecal leukocytes in stool specimens submitted for Clostridium difficile toxin assay. Diagn Microbiol Infect Dis 1993; 16: 313–5
  • Yong W H, Mattia A R, Ferraro M J. Comparison of fecal lactoferrin latex agglutination assay and methylene blue microscopy for detection of fecal leukocytes in Clostridium difficile-associated disease. J Clin Microbiol 1994; 32: 1360–1
  • Schleupner M A, Garner D C, Sosnowski K M, et al. Concurrence of Clostridium difficile toxin A enzyme-linked immunosorbent assay, fecal lactoferrin assay, and clinical criteria with C. difficile cytotoxin titer in two patient cohorts. J Clin Microbiol 1995; 33: 1755–9
  • Shanholtzer C J, Willard K E, Holter J J, et al. Comparison of the VIDAS Clostridium difficile toxin A immunoassay with C. difficile culture and cytotoxin and latex tests. J Clin Microbiol 1992; 30: 1837–40
  • Mattia A R, Doem G V, Clark J, et al. Comparison of four methods in the diagnosis of Clostridium difficile disease. Eur J Clin Microbiol Infect Dis 1993; 12: 882–6
  • Riederer K M, Lawson P, Held M S, et al. Diagnosis of Clostridium difficile-associated diarrhea: comparison of three rapid methods employing different markers for detection. Can J Microbiol 1995; 41: 88–91
  • Whittier S, Shapiro D S, Kelly W F, et al. Evaluation of four commercially available enzyme immunoassays for laboratory diagnosis of Clostridium difficile-associated diseases. J Clin Microbiol 1993; 31: 2861–5
  • Merz C S, Kramer C, Forman M, et al. Comparison of four commercially available rapid enzyme immunoassays with cytotoxin assay for detection of Clostridium difficile toxin(s) from stool specimens. J Clin Microbiol 1994; 32: 1142–7
  • Knapp C C, Sandin R L, Hall G S, et al. Comparison of Vidas Clostridium difficile toxin A assay and Premier C. difficile toxin A assay to cytotoxin B tissue culture assay for the detection of toxins of C. difficile. Diagn Microbiol Infect Dis 1993; 17: 7–12
  • Forward K R, Dalton M T, Kerr E, et al. Comparison of TechLab Clostridium difficile Tox-A enzyme immunoassay and Bartels Prima System Toxin-A EIA. Diagn Microbiol Infect Dis 1994; 20: 1–5
  • Arrow S A, Croese L. Bowman RA, et al. Evaluation of three commercial enzyme immunoassay kits for detecting faecal Clostridium difficile toxins. J Clin Pathol 1994; 47: 954–6
  • Altaic S S, Meyer P, Dryja D. Comparison of two commercially available enzyme immunoassays for detection of Clostridium difficile in stool specimens. J Clin Microbiol 1994; 32: 51–3
  • Bowman R A, Arrow S, Croese L, et al. Evaluation of an enzyme immunoassay kit for the detection of Clostridium difficile enterotoxin. Pathology 1994; 26: 480–1
  • Schue V, Green G A, Monteil H. Comparison of the ToxA test with cytotoxicity assay and culture for the detection of Clostridium difficile-associated diarrhoea disease. J Med Microbiol 1994; 41: 316–8
  • Green G A, Riot B, Monteil H. Evaluation of an oligonucleotide probe and an immunological test for direct detection of toxigenic Clostridium difficile in stool samples. Eur J Clin Microbiol Infect Dis 1994; 13: 576–81
  • Wilkins E. Trés difficile. J Infect 1993; 26: 1–7
  • Wolfhagen M J, Meyer K, Fluit A C, et al. Clinical significance of Clostridium difficile and its toxins in faeces of immunocompromised children. Gut 1994; 35: 1608–12
  • Baron E J, Peterson L R, Finegold S M. Bailey and Scon's diagnostic microbiology, 9th ed. Mosby, St. Louis 1994; 247
  • Holdeman L V, Cato E P, Moore W EC. Anaerobe laboratory manual, 4th ed. Anaerobe Laboratory, VPISU, Blacksburg, VA 1977
  • Summanen P, Baron E J, Citron D M, et al. Wadsworth anaerobic bacteriology manual, 5th ed. Star, Belmont, CA 1993
  • Hanff P A, Zaleznik D F, Kent K C, et al. Use of heat shock for culturing Clostridium difficile from rectal swabs. Clin Infect Dis 1993; 16(Suppl 4))S245–7
  • Marler L M, Siders J A, Wolters L C, et al. Comparison of five cultural procedures for isolation of Clostridium difficile from stools. J Clin Microbiol 1992; 30: 514–6
  • Mundy L S, Shanholtzer C J, Willard K E, et al. Laboratory detection of Clostridium difficile. A comparison of media and incubation systems. Am J Clin Pathol 1995; 103: 52–6
  • Pfeiffer S, Cox M. Enzymatic reactions of Clostridium difficile in aerobic and anaerobic environments with the Rapid ID-ANA II identification system. J Clin Microbiol 1993; 31: 279–82
  • Barbut F, Revel R, Ephraim R, et al. Evaluation of a rapid enzyme immunoassay for the detection of Clostridium difficile in stools [letter]. Eur J Clin Microbiol Infect Dis 1994; 13: 277–8
  • Avesani A, Cambiaso C, Guarin J L, et al. A particle counting immunoassay for the direct detection of Clostridium difficile serogroup specific antigen in faecal specimens. J Med Microbiol 1994; 40: 270–4
  • Knudsen J D, Tvede M. Demonstration of toxin A and B by polymerase chain reaction and McCoy cell assay in clinical isoplates of Clostridium difficile from Denmark. APMIS 1993; 101: 18–22
  • Gumerlock P H, Tang Y J, Weiss J B, et al. Specific detection of toxigenic strains of Clostridium difficile in stool specimens. J Clin Microbiol 1993; 31: 507–11
  • Tang Y J, Gumerlock P H, Weiss J B, et al. Specific detection of Clostridium difficile toxin A gene sequences in clinical isolates. Mol Cell Probes 1994; 8: 463–7
  • Kuhl S J, Tang Y J, Navarro L, et al. Diagnosis and monitoring of Clostridium difficile infections with the polymerase chain reaction. Clin Infect Dis 1993; 16(Suppl 4))S234–8
  • Kato N, Ou C Y, Kato H, et al. Detection of toxigenic Clostridium difficile in stool specimens by the polymerase chain reaction. J Infect Dis 1993; 167: 455–8
  • Boondeekhun H S, Gurtier V, Odd M L, et al. Detection of Clostridium difficile enterotoxin gene in clinical specimens by the polymerase chain reaction. J Med Microbiol 1993; 38: 384–7
  • Ratcliff R M, Goodwin A A, Lanser J A. Use of gene amplification to detect Clostridium difficile in clinical specimens. Pathology 1994; 26: 477–9
  • Wolfhagen M JHM, Fluit A C, Torensma R, et al. Rapid detection of toxigenic Clostridium difficile in fecal samples by magnetic immuno PCR assay. J Clin Microbiol 1994; 32: 1929–33
  • Wolfhagen M JHM, Fluit A C, Janszen M, et al. Detection of toxigenic Clostridium difficile in fecal samples by colony blot hybridization. Eur J Clin Microbiol Infect Dis 1993; 12: 463–6
  • Marts B C, Longo W E, Vernava A M, et al. Patterns and prognosis of Clostridium difficile colitis. Dis Colon Rectum 1994; 37: 837–45
  • Ross T, Greene J N. Treatment of pseudomernbranous colitis associated with Clostridium difficile. Antimicrob Infect Dis New 1994; 13: 69–71
  • Bublin J G, Barton T L. Rectal use of vancomycin. Ann Pharmacother 1994; 28: 1357–8
  • Segreti J, Goodman L J, Trenholem G M. In vitro activity of new quinoxaline compounds against Campylobacter species and Clostridium difficile. Diagn Microbiol Infect Dis 1993; 17: 177–9
  • Wenisch C, Etzersdorfer E, Breyer S, et al. Intravenous teicoplanin does not prevent Clostridium difficile-associated diarrhea. Clin Invest 1994; 72: 922–4
  • Anon. Treatment of Clostridium difficile-associated diarrhea and colitis with an oral preparation of teicoplanin; a dose finding study. The Swedish CD AD Study Group. Scand J Infect Dis 1994; 26: 309–16
  • Roberts M C, McFarland L V, Mullany P, et al. Characterization of the genetic basis of antibiotic resistance in Clostridium difficile. J Antimicrob Chemother 1994; 33: 419–29
  • Lipsett P A, Samantaray D K, Tam M L, et al. Pseudomernbranous colitis: a surgical disease?. Surgery 1994; 116: 491–6
  • Agnifili A, Gola P, Marino M, et al. The role and timing of surgery in the treatment of pseudomernbranous colitis. A case complicated by toxic megacolon. Hepatol Gastroenterol 1994; 41: 394–6
  • Morris L L, Villalba M R, Glover J L. Management of pseudmembranous colitis. Am Surg 1994; 60: 551–2
  • Rubin M S, Bodenstein L E, Kent K C. Severe Clostridium difficile colitis. Dis Colon Rectum 1995; 38: 350–4
  • Tjellström B, Stenhammer L, Eriksson S, et al. Oral immunoglobulin A supplement in treatment of Clostridium difficile enteritis [letter]. Lancet 1993; 314: 701–2
  • Wamy M, Denie C, Delmée M, et al. Gamma globulin administration in relapsing Clostridium difficile-induced pseudomernbranous colitis with a defective antibody response to toxin A. Acta Clin Belg 1995; 50: 36–9
  • Heerze L D, Klem M A, Talbot J A, et al. Oligosaccharide sequences attached to an inert support (SYNSORB) as potential therapy for antibiotic-associated diarrhea and pseudomernbranous colitis. J Infect Dis 1994; 169: 1291–6
  • Loizeau E. Peut-on prévenir les diarrhées associées aux antibiotiques. Ann Gastroenterol Hepatol 1993; 29: 15–8
  • Surawicz C M, McFarland L V, Elmer G, et al. Treatment of recurrent Clostridium difficile colitis with vancomycin and Saccharomyces boulardii. Am J Gastroenterol 1989; 84: 1285–7
  • Buts J P, Corthier G, Delmée M. Saccharomyces boulardii for Clostridium difficile-associated enteropathies in infants. J Pediatr Gastroenterol Nutr 1993; 16: 419–25
  • Schellenberg D, Bonington A, Champion C M, et al. Treatment of Clostridium difficile diarrhoea with brewer's yeast [letter]. Lancet 1994; 343: 171–2
  • Chia J KS, Chan S M, Goldstein H. Baker's yeast as adjunctive therapy for relapses of Clostridium difficile diarrhea [letter]. Clin Infect Dis 1995; 20: 1581
  • Bergogne-Berezin E. Impact écologique de l'antibiothérapie. Place des microorganismes de substitution dans le control des diarrhées et colites associées aux antibiotiques. Presse Med 1995; 24: 145–8; 151–2; 155–6
  • McFarland L V, Bemasconi P. Saccharomyces boulardii: a review of an innovative biotherapeutic agent. Microb Ecol Health Dis 1993; 6: 157–71
  • Pear S M, Williamson T H, Bettin K M, et al. Decrease in nosocomial Clostridium difficile-associated diarrhea by restricting clindamycin use. Ann Intern Med 1994; 120: 272–7
  • Schuller I, Sana V, Lin L, et al. Investigation and management of Clostridium difficile colonisation in a paediatric oncology unit. Arch Dis Child 1995; 72: 219–22
  • Skoutelis A T, Westenfelder G O, Beckerdite M, et al. Hospital carpeting and epidemiology of Clostridium difficile. Am J Infect Control 1994; 22: 212–7
  • Samore M H. Epidemiology of nosocomial Clostridium difficile infection. Compr Ther 1993; 19: 151–6
  • Jemigan J A, Giuliano K, Guerrant R C, et al. Effect of disposable thermometer use on rates of nosocomial Clostridium difficile diarrhea and total nosocomial infection. Abstr 33rd ICAAC 1993; 130
  • Bettin K, Clabots C, Mathie P, et al. Effectiveness of liquid soap vs. chlorhexidine gluconate for the removal of Clostridium difficile from bare hands and gloved hands. Infect Control Hosp Epidemiol 1994; 15: 697–1, 1902.
  • Rutala W A, Gergen M F, Weber D J. Inactivation of Clostridium difficile spores by disinfectants. Infect Control Hosp Epidemiol 1993; 14: 36–9
  • Johnson S, Homann S R, Bettin K M, et al. Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with vancomycin and metronidazole. Ann Intern Med 1992; 117: 297–302
  • Cohen R S, DiMariano A J, Allen M L, Jr. Fecal Clostridium difficile carriage among medical housestaff. N J Med 1994; 91: 327–30
  • Surawicz C M, Elmer G W, Speelman P, et al. Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology 1989; 96: 981–8
  • Tempé J D, Steidel A L, Blehaut H, et al. Prévention par Saccharomyces boulardii des diarrhées de l'alimentation entérale à débit continu. Sem Hop Paris 1983; 59: 1409–12

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