Microbial lectins and their prospective mitogenic potential

References

• Abraham SN, Sun D, Dale JB, Beachey EH. (1988). Conservation of the D-mannose-adhesion protein among type 1 fimbriated members of the family Enterobacteriaceae. Nature, 336, 682–684
   PubMedGoogle Scholar
• Adams L, Scott GK, Weinberg CS. (1996). Biphasic modulation of cell growth by recombinant human galectin-1. Biochim Biophys Acta, 1312, 137–144
   PubMed Web of Science ®Google Scholar
• Alexandre KB, Gray ES, Pantophlet R, Moore PL, McMahon JB, Chakauya E, O’Keefe BR, Chikwamba R, Morris L. (2011). Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site. J Virol, 85, 9039–9050
   PubMedGoogle Scholar
• Alfonso A, Román Y, Vieytes MR, Ofuji K, Satake M, Yasumoto T, Botana LM. (2005). Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes. Biochem Pharmacol, 69, 1627–1636
   PubMedGoogle Scholar
• Allison JP, Krummel MF. (1995). The Yin and Yang of T cell costimulation. Science, 270, 932–933
   PubMed Web of Science ®Google Scholar
• Amano K, Katayama H, Saito A, Ando A, Nagata Y. (2012). Aleuria aurantia lectin exhibits antifungal activity against Mucor racemosus. Biosci Biotechnol Biochem, 76, 967–970
   PubMed Web of Science ®Google Scholar
• Ambrosi M, Cameron NR, Davis BG. (2005). Lectins: tools for the molecular understanding of the glycocode. Org Biomol Chem, 3, 1593–1608
   PubMed Web of Science ®Google Scholar
• Ashraf MT, Khan RH. (2003). Mitogenic lectins. Med Sci Monit, 9, RA265–RA269
   PubMedGoogle Scholar
• Atluru S, Atluru D. (1991). Evidence that genistein, a protein-tyrosine kinase inhibitor, inhibits CD28 monoclonal-antibody-stimulated human T cell proliferation. Transplantation, 51, 448–450
   PubMedGoogle Scholar
• Avichezer D, Gilboa-Garber N. (1987). PA-II, the L-fucose and D-mannose binding lectin of Pseudomonas aeruginosa stimulates human peripheral lymphocytes and murine splenocytes. FEBS Lett, 216, 62–66
   PubMedGoogle Scholar
• Axelsson B, Kimura A, Hammarström S, Wigzell H, Nilsson K, Mellstedt H. (1978). Helix pomatia A hemagglutinin: Selectivity of binding to lymphocyte surface glycoproteins on T cells and certain B cells. Eur J Immunol, 8, 757–764
   PubMedGoogle Scholar
• Bah CS, Fang EF, Ng TB, Mros S, McConnell M, Bekhit Ael-D. (2011). Purification and characterization of a rhamnose-binding chinook salmon roe lectin with antiproliferative activity toward tumor cells and nitric oxide-inducing activity toward murine macrophages. J Agric Food Chem, 59, 5720–5728
   PubMed Web of Science ®Google Scholar
• Bains JS, Dhuna V, Singh J, Kamboj SS, Nijjar KK, Agrewala JN. (2005). Novel lectins from rhizomes of two Acorus species with mitogenic activity and inhibitory potential towards murine cancer cell lines. Int Immunopharmacol, 5, 1470–1478
   PubMed Web of Science ®Google Scholar
• Baksh S, Burakoff SJ. (2000). The role of calcineurin in lymphocyte activation. Semin Immunol, 12, 405–415
   PubMedGoogle Scholar
• Barondes SH, Cooper DN, Gitt MA, Leffler H. (1994). Galectins. Structure and function of a large family of animal lectins. J Biol Chem, 269, 20807–20810
   PubMed Web of Science ®Google Scholar
• Bergström M, Aström E, Påhlsson P, Ohlson S. (2012). Elucidating the selectivity of recombinant forms of Aleuria aurantia lectin using weak affinity chromatography. J Chromatogr B Analyt Technol Biomed Life Sci, 885-886, 66–72
   PubMedGoogle Scholar
• Bertozzi CR, Kiessling LL. (2001). Chemical glycobiology. Science, 291, 2357–2364
   PubMed Web of Science ®Google Scholar
• Bessler W, Resch K, Ferber E. (1976). Valency-dependent stimulating effects of lima bean lectins on lymphocytes of different species. Biochem Biophys Res Commun, 69, 578–585
   PubMedGoogle Scholar
• Bhat N, Fischinger PJ, Seth A, Watson D, Papas T. (1996). Pleiotropic functions of ETS-1. Int J Oncol, 8, 841–846
   PubMedGoogle Scholar
• Bhowal J, Guha AK, Chatterjee BP. (2005). Purification and molecular characterization of a sialic acid specific lectin from the phytopathogenic fungus Macrophomina phaseolina. Carbohydr Res, 340, 1973–1982
   PubMedGoogle Scholar
• Bird KT, Chiles TC, Longley RE, Kendrick AF, Kinkema MD. (1993). Agglutinins from marine macroalgae of the southeastern United States. J Appl Phycol, 5, 213–218
   Google Scholar
• Bjune G, Barnetson RS, Ridley DS, Kronvall G. (1976). Lymphocyte transformation test in leprosy; correlation of the response with inflammation of lesions. Clin Exp Immunol, 25, 85–94
   PubMed Web of Science ®Google Scholar
• Blair PJ, Riley JL, Levine BL, Lee KP, Craighead N, Francomano T, Perfetto SJ, Gray GS, Carreno BM, June CH. (1998). Cutting edge: CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-XL induction. J Immunol, 160, 12–15
   PubMed Web of Science ®Google Scholar
• Blasco E, Barra A, Nicolas M, Lecron JC, Wijdenes J, Preud’homme JL. (1995). Proliferative response of human CD4+ T lymphocytes stimulated by the lectin jacalin. Eur J Immunol, 25, 2010–2018
   PubMedGoogle Scholar
• Blunden G, Rogers DJ, Farnham WF. (1975). Survey of British seaweeds for hemagglutinins. Lloydia, 38, 162–168
   PubMedGoogle Scholar
• Bovi M, Carrizo ME, Capaldi S, Perduca M, Chiarelli LR, Galliano M, Monaco HL. (2011). Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms. Glycobiology, 21, 1000–1009
   PubMedGoogle Scholar
• Boyd MR, Gustafson KR, McMahon JB, Shoemaker RH, O’Keefe BR, Mori T, Gulakowski RJ, Wu L, Rivera MI, Laurencot CM, Currens MJ, Cardellina JH 2nd, Buckheit RW Jr, Nara PL, Pannell LK, Sowder RC 2nd, Henderson LE. (1997). Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: Potential applications to microbicide development. Antimicrob Agents Chemother, 41, 1521–1530
   PubMed Web of Science ®Google Scholar
• Boyd WC, Almodovar LR, Boyd LG. (1966). Agglutinins from marine algae for human erythrocytes. Transfusion, 6, 82–83
   Web of Science ®Google Scholar
• Brenchley JM, Douek DC, Ambrozak DR, Chatterji M, Betts MR, Davis LS, Koup RA. (2002). Expansion of activated human naïve T-cells precedes effector function. Clin Exp Immunol, 130, 432–440
   PubMedGoogle Scholar
• Brown MH, Cantrell DA, Brattsand G, Crumpton MJ, Gullberg M. (1989). The CD2 antigen associates with the T-cell antigen receptor CD3 antigen complex on the surface of human T lymphocytes. Nature, 339, 551–553
   PubMed Web of Science ®Google Scholar
• Cao X, Mao D, Wang C, Zeng B, Wang A, Lu M, Xu C. (2009). A D-galactose-binding lectin with mitogenic activity from Musca domestica pupae. Zoolog Sci, 26, 249–253
   PubMedGoogle Scholar
• Carrizo ME, Capaldi S, Perduca M, Irazoqui FJ, Nores GA, Monaco HL. (2005). The antineoplastic lectin of the common edible mushroom (Agaricus bisporus) has two binding sites, each specific for a different configuration at a single epimeric hydroxyl. J Biol Chem, 280, 10614–10623
   PubMed Web of Science ®Google Scholar
• Cavada BS, Grangeiro TB, Ramos MV, Cordeiro EF, Oliveira JTA, Moreira RA. (1996). Isolation and partial characterization of a lectin from Dioclea rostrata Benth seeds. R Bras Fisiol Veg, 8, 31–36
   Google Scholar
• Chan YS, Wong JH, Fang EF, Pan W, Ng TB. (2012). Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells. PLoS ONE, 7, e38961
   PubMed Web of Science ®Google Scholar
• Chen S, LaRoche T, Hamelinck D, Bergsma D, Brenner D, Simeone D, Brand RE, Haab BB. (2007). Multiplexed analysis of glycan variation on native proteins captured by antibody microarrays. Nat Methods, 4, 437–444
   PubMed Web of Science ®Google Scholar
• Cheung AH, Wong JH, Ng TB. (2009). Musa acuminata (Del Monte banana) lectin is a fructose-binding lectin with cytokine-inducing activity. Phytomedicine, 16, 594–600
   PubMed Web of Science ®Google Scholar
• Chiariotti L, Benvenuto G, Zarrilli R, Rossi E, Salvatore P, Colantuoni V, Bruni CB. (1994). Activation of the galectin-1 (L-14-I) gene from nonexpressing differentiated cells by fusion with undifferentiated and tumorigenic cells. Cell Growth Differ, 5, 769–775
   PubMedGoogle Scholar
• Chilson OP, Kelly-Chilson AE. (1989). Mitogenic lectins bind to the antigen receptor on human lymphocytes. Eur J Immunol, 19, 389–396
   PubMed Web of Science ®Google Scholar
• Clark EA, Ledbetter JA. (1994). How B and T cells talk to each other. Nature, 367, 425–428
   PubMed Web of Science ®Google Scholar
• Clipstone NA, Crabtree GR. (1992). Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature, 357, 695–697
   PubMed Web of Science ®Google Scholar
• Coelho JS, Santos ND, Napoleão TH, Gomes FS, Ferreira RS, Zingali RB, Coelho LC, Leite SP, Navarro DM, Paiva PM. (2009). Effect of Moringa oleifera lectin on development and mortality of Aedes aegypti larvae. Chemosphere, 77, 934–938
   PubMed Web of Science ®Google Scholar
• Coelho MB, Desouza IA, Freire MG, Marangoni S, Antunes E, Macedo ML. (2006). Neutrophil migration in mice induced by a mannose-binding lectin isolated from Annona coriacea seeds. Toxicon, 48, 529–535
   PubMedGoogle Scholar
• Coelho MB, Freire MG, Toyama MH, Marangoni S, Novello JC, Macedo ML. (2003). Purification and characterization of a lectin from Annona coriacea seeds. Protein Pept Lett, 10, 165–173
   PubMedGoogle Scholar
• Coelho MB, Marangoni S, Macedo ML. (2007). Insecticidal action of Annona coriacea lectin against the flour moth Anagasta kuehniella and the rice moth Corcyra cephalonica (Lepidoptera: Pyralidae). Comp Biochem Physiol C Toxicol Pharmacol, 146, 406–414
   PubMedGoogle Scholar
• Coltri KC, Oliveira LL, Pinzan CF, Vendruscolo PE, Martinez R, Goldman MH, Panunto-Castelo A, Roque-Barreira MC. (2008). Therapeutic administration of KM+ lectin protects mice against Paracoccidioides brasiliensis infection via interleukin-12 production in a toll-like receptor 2-dependent mechanism. Am J Pathol, 173, 423–432
   PubMedGoogle Scholar
• Cooper GM, Hausman RE. (2007). The cell: A molecular approach. 4th ed. Washington DC: ASM Press
   Google Scholar
• Coriolano MC, de Melo CM, Santos AJ, Pereira VR, Coelho LC. (2012). Rachycentron canadum (cobia) lectin promoted mitogenic response in mice Balb/c splenocytes. Scand J Immunol, 76, 567–572
   PubMed Web of Science ®Google Scholar
• Correia JL, do Nascimento AS, Cajazeiras JB, Gondim AC, Pereira RI, de Sousa BL, da Silva AL, Garcia W, Teixeira EH, do Nascimento KS, da Rocha BA, Nagano CS, Sampaio AH, Cavada BS. (2011). Molecular characterization and tandem mass spectrometry of the lectin extracted from the seeds of Dioclea sclerocarpa Ducke. Molecules, 16, 9077–9089
   PubMedGoogle Scholar
• Crews CM, Alessandrini A, Erikson RL. (1992). The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science, 258, 478–480
   PubMed Web of Science ®Google Scholar
• Crews CM, Alessandrini AA, Erikson RL. (1991). Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine. Proc Natl Acad Sci USA, 88, 8845–8849
   PubMedGoogle Scholar
• D’adamo PJ. (1990). Lectins and mitogens. Official website of Dr. Peter D’adamo & The Blood Type Diet. Available: http://www.dadamo.com/science_lectins_mitogens.htm. Accessed on 12 May 2012
   Google Scholar
• De La Rosa J, Le Gros HL, Geller Jr AM, Kotb M. (1992). Changes in the relative amount of subunits of methionine adenosyltransferase in human lymphocytes upon stimulation with a polyclonal T cell mitogen. J Biol Chem, 267, 10699–10704
   PubMedGoogle Scholar
• De Mejía EG, Prisecaru VI. (2005). Lectins as bioactive plant proteins: A potential in cancer treatment. Crit Rev Food Sci Nutr, 45, 425–445
   PubMed Web of Science ®Google Scholar
• de Melo CM, Paim BA, Zecchin KG, Morari J, Chiaratti MR, Correia MT, Barroso Coelho LC, Paiva PM. (2010). Cramoll 1,4 lectin increases ROS production, calcium levels, and cytokine expression in treated spleen cells of rats. Mol Cell Biochem, 342, 163–169
   PubMed Web of Science ®Google Scholar
• de Oliveira Silva F, das Neves Santos P, de Melo CM, Teixeira EH, de Sousa Cavada B, Arruda FV, Cajazeiras JB, Almeida AC, Pereira VA, Porto AL. (2011). Immunostimulatory activity of ConBr: A focus on splenocyte proliferation and proliferative cytokine secretion. Cell Tissue Res, 346, 237–244
   PubMedGoogle Scholar
• Dong Q, Sugiura T, Toyohira Y, Yoshida Y, Yanagihara N, Karasaki Y. (2011). Stimulation of IFN-γ production by garlic lectin in mouse spleen cells: Involvement of IL-12 via activation of p38 MAPK and ERK in macrophages. Phytomedicine, 18, 309–316
   PubMedGoogle Scholar
• Downward J, Graves J, Cantrell D. (1992). The regulation and function of p21ras in T cells. Immunol Today, 13, 89–92
   PubMedGoogle Scholar
• Drake PM, Cho W, Li B, Prakobphol A, Johansen E, Anderson NL, Regnier FE, Gibson BW, Fisher SJ. (2010). Sweetening the pot: Adding glycosylation to the biomarker discovery equation. Clin Chem, 56, 223–236
   PubMed Web of Science ®Google Scholar
• Edgar VA, Genaro AM, Cremaschi G, Sterin-Borda L. (1998). Fluoxetine action on murine T-lymphocyte proliferation: Participation of PKC activation and calcium mobilisation. Cell Signal, 10, 721–726
   PubMedGoogle Scholar
• Erjavec J, Kos J, Ravnikar M, Dreo T, Sabotic J. (2012). Proteins of higher fungi–from forest to application. Trends Biotechnol, 30, 259–273
   PubMed Web of Science ®Google Scholar
• Esko JD, Sharon N. (2009). Microbial lectins: Hemagglutinins, adhesins, and toxins. In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, eds. Essentials of Glycobiology, 2nd ed. New York: Cold Spring Harbor Laboratory Press, 489–500
   Google Scholar
• Feng K, Liu QH, Ng TB, Liu HZ, Li JQ, Chen G, Sheng HY, Xie ZL, Wang HX. (2006). Isolation and characterization of a novel lectin from the mushroom Armillaria luteo-virens. Biochem Biophys Res Commun, 345, 1573–1578
   PubMedGoogle Scholar
• Feng LI, HuaAn W, YongJie Z, Min AN, XingZhong L. (2011). Purification and characterization of a novel immunomodulatory protein from the medicinal mushroom Trametes versicolor. Sci China Life Sci, 54, 379–385
   PubMedGoogle Scholar
• Feng S, Yang N, Pennathur S, Goodison S, Lubman DM. (2009). Enrichment of glycoproteins using nanoscale chelating concanavalin A monolithic capillary chromatography. Anal Chem, 81, 3776–3783
   PubMed Web of Science ®Google Scholar
• Fernandez-Botran R, Sanders VM, Oliver KG, Chen YW, Krammer PH, Uhr JW, Vitetta ES. (1986). Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation. Proc Natl Acad Sci USA, 83, 9689–9693
   PubMed Web of Science ®Google Scholar
• Ford WW. (1911). The distribution of haemolysis agglutinins and poisons in fungi, especially the Amanitas, the Entolomas, the Lactarius and the Inocybes. J Pharmacol Exp Ther, 2, 285–318
   Google Scholar
• Fouillit M, Joubert-Caron R, Poirier F, Bourin P, Monostori E, Levi-Strauss M, Raphael M, Bladier D, Caron M. (2000a). Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. Glycobiology, 10, 413–419
   PubMed Web of Science ®Google Scholar
• Fouillit M, Poirier F, Monostori E, Raphael M, Bladier D, Joubert-Caron R, Caron M. (2000b). Analysis of galectin 1-mediated cell signaling by combined precipitation and electrophoresis techniques. Electrophoresis, 21, 275–280
   PubMed Web of Science ®Google Scholar
• Fraser JD, Newton ME, Weiss A. (1992). CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. J Exp Med, 175, 1131–1134
   PubMedGoogle Scholar
• Gabius HJ, Siebert HC, André S, Jiménez-Barbero J, Rüdiger H. (2004). Chemical biology of the sugar code. Chembiochem, 5, 740–764
   PubMed Web of Science ®Google Scholar
• Gallagher RB, Whelan A, Feighery C. (1986). Studies on the accessory requirement for T lymphocyte activation by concanavalin A. Clin Exp Immunol, 66, 118–125
   PubMedGoogle Scholar
• Gately MK, Desai BB, Wolitzky AG, Quinn PM, Dwyer CM, Podlaski FJ, Familletti PC, Sinigaglia F, Chizonnite R, Gubler U. (1991). Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol, 147, 874–882
   PubMed Web of Science ®Google Scholar
• Gerner C, Holzmann K, Grimm R, Sauermann G. (1998). Similarity between nuclear matrix proteins of various cells revealed by an improved isolation method. J Cell Biochem, 71, 363–374
   PubMedGoogle Scholar
• Ghosh S, Majumder M, Majumder S, Ganguly NK, Chatterjee BP. (1999). Saracin: A lectin from Saraca indica seed integument induces apoptosis in human T-lymphocytes. Arch Biochem Biophys, 371, 163–168
   PubMed Web of Science ®Google Scholar
• Ghysdael J, Boureux A. (1997). The Ets family of transcriptional regulators. In: Yaniv M, Ghysdael J, eds. Oncogenes as Transcriptional Regulators. Switzerland: Birkhauser Verlag Basel, 29–89
   Google Scholar
• Gilboa-Garber N, Avichezer D, Rozenszajn LA. (1986). Stimulation of peripheral lymphocytes from cancer patients and healthy subjects by Pseudomonas aeruginosa lectin. FEMS Microbiol Lett, 34, 237–240
   Web of Science ®Google Scholar
• Gilboa-Garber N. (1982). Pseudomonas aeruginosa lectins. Meth Enzymol, 83, 378–385
   PubMed Web of Science ®Google Scholar
• Gillis S, Ferm MM, Ou W, Smith KA. (1978). T cell growth factor: Parameters of production and a quantitative microassay for activity. J Immunol, 120, 2027–2032
   PubMed Web of Science ®Google Scholar
• Gilmore TD. (1999). The Rel/NF-kappaB signal transduction pathway: Introduction. Oncogene, 18, 6842–6844
   PubMed Web of Science ®Google Scholar
• Gollob JA, Li J, Reinherz EL, Ritz J. (1995). CD2 regulates responsiveness of activated T cells to interleukin 12. J Exp Med, 182, 721–731
   PubMedGoogle Scholar
• Graves BJ, Petersen JM. (1998). Specificity within the ets family of transcription factors. Adv Cancer Res, 75, 1–55
   PubMed Web of Science ®Google Scholar
• Greene WC, Fleisher TA, Waldmann TA. (1981b). Suppression of human T and B lymphocyte activation by Agaricus bisporus lectin. I. Suggestive evidence for a surface “suppressor” receptor in human lymphocytes. J Immunol, 126, 580–586
   PubMedGoogle Scholar
• Greene WC, Fleisher TA, Waldmann TA. (1981a). Soluble suppressor supernatants elaborated by concanavalin A-activated human mononuclear cells. I. Characterization of a soluble suppressor T cell proliferation. J Immunol, 126, 1185–1191
   PubMed Web of Science ®Google Scholar
• Greene WC, Waldmann TA. (1980). Inhibition of human lymphocyte proliferation by the nonmitogenic lectin wheat germ agglutinin. J Immunol, 124, 2979–2987
   PubMed Web of Science ®Google Scholar
• Grillon C, Monsigny M, Kieda C. (1991). Soluble human lymphocyte sugar binding proteins with immunosuppressive activity. Immunol Lett, 28, 47–55
   PubMedGoogle Scholar
• Guinan EC, Gribben JG, Boussiotis VA, Freeman GJ, Nadler LM. (1994). Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood, 84, 3261–3282
   PubMed Web of Science ®Google Scholar
• Gunther GR, Wang JL, Edelman GM. (1974). The kinetics of cellular commitment during stimulation of lymphocytes by lectins. J Cell Biol, 62, 366–377
   PubMedGoogle Scholar
• Gupta S, Weiss A, Kumar G, Wang S, Nel A. (1994). The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant. J Biol Chem, 269, 17349–17357
   PubMed Web of Science ®Google Scholar
• Habu S, Raff MC. (1977). Accessory cell dependence of lectin-induced proliferation of mouse T lymphocytes. Eur J Immunol, 7, 451–457
   PubMed Web of Science ®Google Scholar
• Han CH, Liu QH, Ng TB, Wang HX. (2005). A novel homodimeric lactose-binding lectin from the edible split gill medicinal mushroom Schizophyllum commune. Biochem Biophys Res Commun, 336, 252–257
   PubMedGoogle Scholar
• Han JW, Yoon KS, Klochkova TA, Hwang MS, Kim GH. (2011). Purification and characterization of a lectin, BPL-3, from the marine green alga Bryopsis plumosa. J Appl Phycol, 23, 745–753
   Web of Science ®Google Scholar
• Hart DA. (1980). Lectins in biological systems: applications to microbiology. Am J Clin Nutr, 33, 2416–2425
   PubMed Web of Science ®Google Scholar
• Heiny BM, Beuth J. (1994). Mistletoe extract standardized for the galactoside-specific lectin (ML-1) induces beta-endorphin release and immunopotentiation in breast cancer patients. Anticancer Res, 14, 1339–1342
   PubMed Web of Science ®Google Scholar
• Ho JC, Sze SC, Shen WZ, Liu WK. (2004). Mitogenic activity of edible mushroom lectins. Biochim Biophys Acta, 1671, 9–17
   PubMedGoogle Scholar
• Hohl HR, Balsiger S. (1986). A model system for the study of fungus host surface interactions: Adhesion of Phytophtora megasperma to protoplasts and mesophyll cells of soybean. In: Lugtenberg B, ed. Recognition in Microbe-Plant Symbiotic and Pathogenic Interaction. Berlin, Heidelberg, Germany: Springer-Verlag, 259–272
   Google Scholar
• Holmström TH, Chow SC, Elo I, Coffey ET, Orrenius S, Sistonen L, Eriksson JE. (1998). Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling. J Immunol, 160, 2626–2636
   PubMed Web of Science ®Google Scholar
• Hori K, Ikegami S, Miyazawa K, Ito K. (1988). Mitogenic and antineoplastic isoagglutinins from the red alga Solieria robusta. Phytochemistry, 27, 2063–2067
   Web of Science ®Google Scholar
• Hori K, Miyazawa K, Ito K. (1981). Hemagglutinins in marine algae. Bull Japan Soc Fish, 52, 323–331
   Google Scholar
• Hori K, Miyazawa K, Ito K. (1987). A mitogenic agglutinin from the red alga Carpopeltis flabelata. Phytochemistry, 26, 1335–1338
   Web of Science ®Google Scholar
• Hori K, Miyazawa K, Ito K. (1990). Some common properties of lectins from marine algae. In: Lindstrom SC, Gabrielson PW, eds. Thirteenth International Seaweed Symposium. Developments in Hydrobiology. Dordrecht: Kluwer Academic Publishers, 561–566. Reprinted from hydrobiologia 204/205
   Google Scholar
• Hsu HC, Hsu CI, Lin RH, Kao CL, Lin JY. (1997). Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea. Biochem J, 323 (Pt 2), 557–565
   PubMedGoogle Scholar
• Huang DY, Prystowsky MB. (1996). Identification of an essential cis-element near the transcription start site for transcriptional activation of the proliferating cell nuclear antigen gene. J Biol Chem, 271, 1218–1225
   PubMedGoogle Scholar
• Huang L, Adachi T, Shimizu Y, Goto Y, Toyama J, Tanaka H, Akashi R, Sawaguchi A, Iwata H, Haga T. (2008). Characterization of lectin isolated from Momordica charantia seed as a B cell activator. Immunol Lett, 121, 148–156
   PubMed Web of Science ®Google Scholar
• Huskens D, Schols D. (2012). Algal lectins as potential HIV microbicide candidates. Mar Drugs, 10, 1476–1497
   PubMed Web of Science ®Google Scholar
• Hutchinson P, Divola LA, Holdsworth SR. (1999). Mitogen-induced T-cell CD69 expression is a less sensitive measure of T-cell function than [(3)H]-thymidine uptake. Cytometry, 38, 244–249
   PubMedGoogle Scholar
• Isakov N, Scholz W, Altman A. (1986). Signal transduction and intracellular events in T-lymphocyte activation. Immunol Today, 7, 271–277
   PubMedGoogle Scholar
• Ishikawa F, Oishi K, Aida K. (1983). Chitin-binding hemagglutinin associated with cell wall of Conidiobolus lamprauges. Agric Biol Chem, 47, 587–592
   Google Scholar
• Izquierdo M, Downward J, Graves JD, Cantrell DA. (1992). Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells. Mol Cell Biol, 12, 3305–3312
   PubMedGoogle Scholar
• Jepson MA, Clark MA, Hirst BH. (2004). M cell targeting by lectins: a strategy for mucosal vaccination and drug delivery. Adv Drug Deliv Rev, 56, 511–525
   PubMed Web of Science ®Google Scholar
• Jeurink PV, Noguera CL, Savelkoul HF, Wichers HJ. (2008). Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells. Int Immunopharmacol, 8, 1124–1133
   PubMed Web of Science ®Google Scholar
• Jiang S, Chen Y, Wang M, Yin Y, Pan Y, Gu B, Yu G, Li Y, Wong BH, Liang Y, Sun H. (2012). A novel lectin from Agrocybe aegerita shows high binding selectivity for terminal N-acetylglucosamine. Biochem J, 443, 369–378
   PubMedGoogle Scholar
• Jimbo M, Koike K, Sakai R, Muramoto K, Kamiya H. (2005). Cloning and characterization of a lectin from the octocoral Sinularia lochmodes. Biochem Biophys Res Commun, 330, 157–162
   PubMedGoogle Scholar
• Jimbo M, Yamaguchi M, Muramoto K, Kamiya H. (2000). Cloning of the Microcystis aeruginosa M228 lectin (MAL) gene. Biochem Biophys Res Commun, 273, 499–504
   PubMedGoogle Scholar
• Jung EC, Kim KD, Bae CH, Kim JC, Kim DK, Kim HH. (2007). A mushroom lectin from ascomycete Cordyceps militaris. Biochim Biophys Acta, 1770, 833–838
   PubMed Web of Science ®Google Scholar
• Jung MG, Lee KP, Choi HG, Kang SH, Klochkova TA, Han JW, Kim GH. (2010). Characterization of carbohydrate combining sites of Bryohealin, an algal lectin from Bryopsis plumosa. J Appl Phycol, 22, 793–802
   Web of Science ®Google Scholar
• Kaba A, Ilunga LA, Chany C. (2000). Role of sarcolectin (SCL) and interferons in coordinated T cell clonal expansion. J Interferon Cytokine Res, 20, 519–525
   PubMedGoogle Scholar
• Kabir S. (1998). Jacalin: a jackfruit (Artocarpus heterophyllus) seed-derived lectin of versatile applications in immunobiological research. J Immunol Methods, 212, 193–211
   PubMed Web of Science ®Google Scholar
• Kamboj SS, Shangary S, Singh J, Kamboj KK, Sandhu RS. (1995). New lymphocyte stimulating monocot lectins from family Araceae. Immunol Invest, 24, 845–855
   PubMed Web of Science ®Google Scholar
• Karasaki Y, Tsukamoto S, Mizusaki K, Sugiura T, Gotoh S. (2001). A garlic lectin exerted an antitumor activity and induced apoptosis in human tumor cells. Food Res Int, 34, 7–13
   Web of Science ®Google Scholar
• Karitskaia IA, Aksenov ND, Zenin VV, Khaidukova AL, Marakhova II. (2006). [Activation of transcriptional factors stat5 and stat3 during human T-lymphocyte proliferation induced by different mitogenic stimuli]. Tsitologiia, 48, 42–49
   PubMedGoogle Scholar
• Karlsson H, DePierre JW, Nässberger L. (1997). Energy levels in resting and mitogen-stimulated human lymphocytes during treatment with FK506 or cyclosporin A in vitro. Biochim Biophys Acta, 1319, 301–310
   PubMedGoogle Scholar
• Kasai K, Hirabayashi J. (1996). Galectins: a family of animal lectins that decipher glycocodes. J Biochem, 119, 1–8
   PubMed Web of Science ®Google Scholar
• Kawakubo A, Makino H, Ohnishi J, Hirohara H, Hori K. (1997). The marine red alga Eucheuma serra J. Agardh, a high yielding source of two isolectins. J Appl Phycol, 9, 331–338
   Web of Science ®Google Scholar
• Kawakubo A, Makino H, Ohnishi J, Hirohara H, Hori K. (1999). Occurrence of highly yielded lectins homologous within the genus Eucheuma. J Appl Phycol, 11, 149–156
   Web of Science ®Google Scholar
• Kern JA, Daniele RP, Nowell PC. (1985). Accessory cells provide more than one signal for lectin mitogen-stimulated proliferation of human lymphocytes. J Leukoc Biol, 38, 495–507
   PubMedGoogle Scholar
• Khil LY, Kim W, Lyu S, Park WB, Yoon JW, Jun HS. (2007). Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells. World J Gastroenterol, 13, 2811–2818
   PubMed Web of Science ®Google Scholar
• Kilpatrick DC, Graham C, Urbaniak SJ. (1986). Inhibition of human lymphocyte transformation by tomato lectin. Scand J Immunol, 24, 11–19
   PubMedGoogle Scholar
• Kilpatrick DC, McCurrach PM. (1987). Wheat germ agglutinin is mitogenic, nonmitogenic and anti-mitogenic for human lymphocytes. Scand J Immunol, 25, 343–348
   PubMedGoogle Scholar
• Kilpatrick DC. (1988). Accessory cell paradox: monocytes enhance or inhibit lectin-mediated human T-lymphocyte proliferation depending on the choice of mitogen. Scand J Immunol, 28, 247–249
   PubMedGoogle Scholar
• Kilpatrick DC. (1991). Lectin interactions with human leukocytes: Mitogenicity, cell separation, clinical applications. In: Kilpatrick DC, Van Driessche E, Bog-Hansen TC, eds. Lectin Reviews. St. Louis: Sigma Chemical Company, 69–80
   Google Scholar
• Kilpatrick DC. (1998). Use of lectins as mitogens for lymphocytes. In: Rhodes JM, Milton JD, eds. Methods in Molecular Medicine Vol 9 Lectin Methods and Protocols. Totowa NJ: Humana Press, 385–392
   Google Scholar
• Kilpatrick DC. (1999). Mechanisms and assessment of lectin-mediated mitogenesis. Mol Biotechnol, 11, 55–65
   PubMed Web of Science ®Google Scholar
• Kim GH, Lee IK, Fritz L. (1995). The wound-healing responses of Antithamnion nipponicum and Griffithsia pacifica (Ceramiales, Rhodophyta) monitored by lectins. Phycol Res, 43, 161–166
   Google Scholar
• Kim WH, Park WB, Gao B, Jung MH. (2004). Critical role of reactive oxygen species and mitochondrial membrane potential in Korean mistletoe lectin-induced apoptosis in human hepatocarcinoma cells. Mol Pharmacol, 66, 1383–1396
   PubMedGoogle Scholar
• Kimura A, Ersson B. (1981). Activation of T lymphocytes by lectins and carbohydrate-oxidizing reagents viewed as an immunological recognition of cell-surface modifications seen in the context of “self” major histocompatibility complex antigens. Eur J Immunol, 11, 475–483
   PubMed Web of Science ®Google Scholar
• Kindt TJ, Goldsby RA, Osborne BA. (2007). Kuby immunology. 6th ed. New York: WH Freeman and Company
   Google Scholar
• Klaus SJ, Sidorenko SP, Clark EA. (1996). CD45 ligation induces programmed cell death in T and B lymphocytes. J Immunol, 156, 2743–2753
   PubMedGoogle Scholar
• Ko JL, Hsu CI, Lin RH, Kao CL, Lin JY. (1995). A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence. Eur J Biochem, 228, 244–249
   PubMedGoogle Scholar
• Kobata T, Jacquot S, Kozlowski S, Agematsu K, Schlossman SF, Morimoto C. (1995). CD27-CD70 interactions regulate B-cell activation by T cells. Proc Natl Acad Sci USA, 92, 11249–11253
   PubMed Web of Science ®Google Scholar
• Koch N, Jung M, Sabat R, Krätzschmar J, Döcke WD, Asadullah K, Volk HD, Grütz G. (2009). IL-10 protects monocytes and macrophages from complement-mediated lysis. J Leukoc Biol, 86, 155–166
   PubMedGoogle Scholar
• Konska G. (2006). Lectins of higher fungi (macromycetes) - Their occurrence, physiological role, and biological activity. Int J Med Mushrooms, 8, 19–30
   Google Scholar
• Kopitz J, von Reitzenstein C, Burchert M, Cantz M, Gabius HJ. (1998). Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture. J Biol Chem, 273, 11205–11211
   PubMed Web of Science ®Google Scholar
• Kouokam JC, Huskens D, Schols D, Johannemann A, Riedell SK, Walter W, Walker JM, Matoba N, O’Keefe BR, Palmer KE. (2011). Investigation of griffithsin’s interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate. PLoS ONE, 6, e22635
   Google Scholar
• Kowaltowski AJ, Castilho RF, Vercesi AE. (2001). Mitochondrial permeability transition and oxidative stress. FEBS Lett, 495, 12–15
   PubMed Web of Science ®Google Scholar
• Krickeberg H, Mauff G, Mertens T, Plum G, Heitmann K. (1990). Lymphocyte proliferation in AIDS-related complex/Walter-Reed 5 patients: response to herpes simplex virus and tuberculin antigen and mitogen during intravenous immunoglobulin treatment. The ARC-IVIG Study Group. Vox Sang, 59 Suppl 1, 38–43
   PubMedGoogle Scholar
• Krummel MF, Allison JP. (1995). CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med, 182, 459–465
   PubMed Web of Science ®Google Scholar
• Lafont V, Dornand J, d’Angeac AD, Monier S, Alcover A, Favero J. (1994). Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex. J Leukoc Biol, 56, 521–524
   PubMedGoogle Scholar
• Lafont V, Rouot B, Favero J. (1998). The Raf-1/mitogen-activated protein kinase kinase-1/extracellular signal-regulated-2 signaling pathway as prerequisite for interleukin-2 gene transcription in lectin-stimulated human primary T lymphocytes. Biochem Pharmacol, 55, 319–324
   PubMedGoogle Scholar
• Landsteiner K, Raubitschek H. (1907). Beobachtungen uber Hämolyse und Hämagglutination. Zbl Bakt I Abt Orig, 45, 600–607
   Google Scholar
• Li Y, Zhang G, Ng TB, Wang H. (2010). A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. J Biomed Biotechnol, 2010, 716515
   PubMedGoogle Scholar
• Li YR, Liu QH, Wang HX, Ng TB. (2008). A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus. Biochim Biophys Acta, 1780, 51–57
   PubMed Web of Science ®Google Scholar
• Liao WR, Lin JY, Shieh WY, Jeng WL, Huang R. (2003). Antibiotic activity of lectins from marine algae against marine vibrios. J Ind Microbiol Biotechnol, 30, 433–439
   PubMed Web of Science ®Google Scholar
• Licastro F, Morini MC, Kretz O, Dirheimer G, Creppy EE, Stirpe F. (1993). Mitogenic activity and immunological properties of bolesatine, a lectin isolated from the mushroom Boletus satanas Lenz. Int J Biochem, 25, 789–792
   PubMedGoogle Scholar
• Lijnen P, Saavedra A, Petrov V. (1997). In vitro proliferative response of human peripheral blood mononuclear cells to concanavalin A. Clin Chim Acta, 264, 91–101
   PubMed Web of Science ®Google Scholar
• Lima HC, Costa FHF, Sampaio AH, Neves SA, Benevides NMB, Teixeira DIA, Rogers DJ, Freitas ALP. (1998). Induction and inhibition of human lymphocyte transformation by the lectin from the red marine alga Amansia multifida. J Appl Phycol, 10, 153–162
   Google Scholar
• Lima ME, Carneiro ME, Nascimento AE, Grangeiro TB, Holanda ML, Amorim RC, Benevides NM. (2005). Purification of a lectin from the marine red alga Gracilaria cornea and its effects on the cattle tick Boophilus microplus (Acari: Ixodidae). J Agric Food Chem, 53, 6414–6419
   PubMedGoogle Scholar
• Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M. (1995). Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science, 268, 286–290
   PubMed Web of Science ®Google Scholar
• Lin WH, Hung CH, Hsu CI, Lin JY. (1997). Dimerization of the N-terminal amphipathic alpha-helix domain of the fungal immunomodulatory protein from Ganoderma tsugae (Fip-gts) defined by a yeast two-hybrid system and site-directed mutagenesis. J Biol Chem, 272, 20044–20048
   PubMed Web of Science ®Google Scholar
• Link NR. (1968). Lymphocytes stimulation. Amsterdam: North-Holland Pub Co
   Google Scholar
• Lipsick JS, Beyer EC, Barondes SH, Kaplan NO. (1980). Lectins from chicken tissues are mitogenic for Thy-1 negative murine spleen cells. Biochem Biophys Res Commun, 97, 56–61
   PubMed Web of Science ®Google Scholar
• Lis H, Sharon N. (1977). Lectins: Their chemistry and application to immunology. In: Sela M, ed. The Antigens. New York: Academic Press Inc, 429–529
   Google Scholar
• Lis H, Sharon N. (1986). Biological properties of lectins. In: Liener IE, Sharon N, Goldstein IJ, eds. The Lectins: Properties, and Applications in Biology and Medicine. New York: Academic Press, 265–291
   Google Scholar
• Lis H, Sharon N. (1998). Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition. Chem Rev, 98, 637–674
   PubMed Web of Science ®Google Scholar
• Liu J, Farmer JD Jr , Lane WS, Friedman J, Weissman I, Schreiber SL. (1991). Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell, 66, 807–815
   PubMed Web of Science ®Google Scholar
• Liu Q, Wang H, Ng TB. (2006). First report of a xylose-specific lectin with potent hemagglutinating, antiproliferative and anti-mitogenic activities from a wild ascomycete mushroom. Biochim Biophys Acta, 1760, 1914–1919
   PubMed Web of Science ®Google Scholar
• Liu Q, Wang H, Ng TB. (2004). Isolation and characterization of a novel lectin from the wild mushroom Xerocomus spadiceus. Peptides, 25, 7–10
   PubMedGoogle Scholar
• Liu Y. (1997). Is CTLA-4 a negative regulator for T-cell activation? Immunol Today, 18, 569–572
   PubMedGoogle Scholar
• Ma P, Magut M, Faller DV, Chen CY. (2002). The role of Ras in T lymphocyte activation. Cell Signal, 14, 849–859
   PubMedGoogle Scholar
• MacDonald HR, Nabholz M. (1986). T-cell activation. Annu Rev Cell Biol, 2, 231–253
   PubMedGoogle Scholar
• Maciel EV, Araújo-Filho VS, Nakazawa M, Gomes YM, Coelho LC, Correia MT. (2004). Mitogenic activity of Cratylia mollis lectin on human lymphocytes. Biologicals, 32, 57–60
   PubMedGoogle Scholar
• Maecker HT, Todd SC, Levy S. (1997). The tetraspanin superfamily: molecular facilitators. FASEB J, 11, 428–442
   PubMed Web of Science ®Google Scholar
• Maeda N, Kawada N, Seki S, Arakawa T, Ikeda K, Iwao H, Okuyama H, Hirabayashi J, Kasai K, Yoshizato K. (2003). Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways. J Biol Chem, 278, 18938–18944
   PubMed Web of Science ®Google Scholar
• Mahalingam A, Geonnotti AR, Balzarini J, Kiser PF. (2011). Activity and safety of synthetic lectins based on benzoboroxole-functionalized polymers for inhibition of HIV entry. Mol Pharm, 8, 2465–2475
   PubMed Web of Science ®Google Scholar
• Maier I, Muller DG. (1986). Sexual pheromones in algae. Biol Bull, 170, 145–175
   Web of Science ®Google Scholar
• Marth JD, Lewis DB, Cooke MP, Mellins ED, Gearn ME, Samelson LE, Wilson CB, Miller AD, Perlmutter RM. (1989). Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck). J Immunol, 142, 2430–2437
   PubMed Web of Science ®Google Scholar
• Mascarell L, Frey JR, Michel F, Lefkovits I, Truffa-Bachi P. (2000). Increased protein synthesis after T cell activation in presence of cyclosporin A. Transplantation, 70, 340–348
   PubMedGoogle Scholar
• Masuda ES, Imamura R, Amasaki Y, Arai K, Arai N. (1998). Signalling into the T-cell nucleus: NFAT regulation. Cell Signal, 10, 599–611
   PubMed Web of Science ®Google Scholar
• Matsuda S, Moriguchi T, Koyasu S, Nishida E. (1998). T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A. J Biol Chem, 273, 12378–12382
   PubMed Web of Science ®Google Scholar
• McCurrach PM, Kilpatrick DC. (1988). Datura lectin is both an anti-mitogen and a co-mitogen acting synergistically with phorbol ester. Scand J Immunol, 27, 31–34
   PubMedGoogle Scholar
• Mehta BA, Maino VC. (1997). Simultaneous detection of DNA synthesis and cytokine production in staphylococcal enterotoxin B activated CD4+ T lymphocytes by flow cytometry. J Immunol Methods, 208, 49–59
   PubMed Web of Science ®Google Scholar
• Meuer SC, Hussey RE, Fabbi M, Fox D, Acuto O, Fitzgerald KA, Hodgdon JC, Protentis JP, Schlossman SF, Reinherz EL. (1984). An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell, 36, 897–906
   PubMed Web of Science ®Google Scholar
• Micewicz ED, Cole AL, Jung CL, Luong H, Phillips ML, Pratikhya P, Sharma S, Waring AJ, Cole AM, Ruchala P. (2010). Grifonin-1: A small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin. PLoS ONE, 5, e14360
   Google Scholar
• Miller OJ. (1970). Autoradiography in human cytogenetics. Adv Hum Genet, 1, 35–130
   PubMedGoogle Scholar
• Miranti CK, Ginty DD, Huang G, Chatila T, Greenberg ME. (1995). Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. Mol Cell Biol, 15, 3672–3684
   PubMedGoogle Scholar
• Modiano JF, Mayor J, Ball C, Chitko-McKown CG, Sakata N, Domenico-Hahn J, Lucas JJ, Gelfand EW. (1999). Quantitative and qualitative signals determine T-cell cycle entry and progression. Cell Immunol, 197, 19–29
   PubMedGoogle Scholar
• Moiseeva EP, Javed Q, Spring EL, de Bono DP. (2000). Galectin 1 is involved in vascular smooth muscle cell proliferation. Cardiovasc Res, 45, 493–502
   PubMed Web of Science ®Google Scholar
• Molchanova V, Chernikov O, Chialovets I, Lukyanov P. (2010). Purification and characterization of the lectin from the marine red alga Tichocarpus crinitus (Gmelin) Rupr. (Rhodophyta). Bot Marina, 53, 69–78
   Google Scholar
• Mori T, O’Keefe BR, Sowder RC 2nd, Bringans S, Gardella R, Berg S, Cochran P, Turpin JA, Buckheit RWJr, McMahon JB, Boyd MR. (2005). Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. J Biol Chem, 280, 9345–9353
   PubMed Web of Science ®Google Scholar
• Morse JH, Witte LD, Goodman DS. (1977). Inhibition of lymphocyte proliferation stimulated by lectins and allogeneic cells by normal plasma lipoproteins. J Exp Med, 146, 1791–1803
   PubMed Web of Science ®Google Scholar
• Mosmann T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods, 65, 55–63
   PubMed Web of Science ®Google Scholar
• Moura RD, Aragão KS, de Melo AA, Carneiro RF, Osório CB, Luz PB, de Queiroz AF, Dos Santos EA, de Alencar NM, Cavada BS. (2012). Holothuria grisea agglutinin (HGA): The first invertebrate lectin with anti-inflammatory effects. Fundam Clin Pharmacol. DOI 10.1111/j.1472-8206.2012.01073.x. [Epub ahead of print]
   Google Scholar
• Na JC, Park BT, Chung WH, Kim HH. (2011). Molecular characterization and mitogenic activity of a lectin from purse crab Philyra pisum. Korean J Physiol Pharmacol, 15, 241–244
   PubMedGoogle Scholar
• Nagre NN, Chachadi VB, Eligar SM, Shubhada C, Pujari R, Shastry P, Swamy BM, Inamdar SR. (2010a). Purification and characterization of a mitogenic lectin from Cephalosporium, a pathogenic fungus causing mycotic keratitis. Biochem Res Int, 2010, 854656
   PubMedGoogle Scholar
• Nagre NN, Chachadi VB, Sundaram PM, Naik RS, Pujari R, Shastry P, Swamy BM, Inamdar SR. (2010b). A potent mitogenic lectin from the mycelia of a phytopathogenic fungus, Rhizoctonia bataticola, with complex sugar specificity and cytotoxic effect on human ovarian cancer cells. Glycoconj J, 27, 375–386
   PubMedGoogle Scholar
• Nakae H, Yumoto H, Matsuo T, Ebisu S. (1994). Mitogenic stimulation of murine B lymphocytes by the N-acetyl-D-galactosamine specific bacterial lectin-like substance from Eikenella corrodens. FEMS Microbiol Lett, 116, 349–353
   PubMed Web of Science ®Google Scholar
• Nashar TO, Hirst TR, Williams NA. (1997). Modulation of B-cell activation by the B subunit of Escherichia coli enterotoxin: receptor interaction up-regulates MHC class II, B7, CD40, CD25 and ICAM-1. Immunology, 91, 572–578
   PubMed Web of Science ®Google Scholar
• Nel AE. (2002). T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J Allergy Clin Immunol, 109, 758–770
   PubMed Web of Science ®Google Scholar
• Neves SA, Dias-Baruff M, Freitas AL, Roque-Barreira MC. (2001). Neutrophil migration induced in vivo and in vitro by marine algal lectins. Inflamm Res, 50, 486–490
   PubMedGoogle Scholar
• Ng TB, Lam YW, Woo NY. (2003). The immunostimulatory activity and stability of grass carp (Ctenopharyngodon idellus) roe lectin. Vet Immunol Immunopathol, 94, 105–112
   PubMedGoogle Scholar
• Ng TB, Ngai PH, Xia L. (2006). An agglutinin with mitogenic and antiproliferative activities from the mushroom Flammulina velutipes. Mycologia, 98, 167–171
   PubMed Web of Science ®Google Scholar
• Ngai PH, Ng TB. (2004). A mushroom (Ganoderma capense) lectin with spectacular thermostability, potent mitogenic activity on splenocytes, and antiproliferative activity toward tumor cells. Biochem Biophys Res Commun, 314, 988–993
   PubMed Web of Science ®Google Scholar
• Nikitina VE, Bogomolova NV, Ponomareva Eg, Sokolov OI. (2004). Effect of Azospirilla lectins on germination capacity of seeds. Microbiology, 31, 354–357
   Google Scholar
• Nishimura M. (2009). Cytokine release from phytohemagglutinin-blast triggered by normal human serum. Transfusion, 49, 602
   PubMedGoogle Scholar
• Nishioka Y, Lipsky PE. (1994). The role of CD40-CD40 ligand interaction in human T cell-B cell collaboration. J Immunol, 153, 1027–1036
   PubMed Web of Science ®Google Scholar
• Novogrodsky A, Katchalski E. (1973). Transformation of neuraminidase-treated lymphocytes by soybean agglutinin. Proc Natl Acad Sci USA, 70, 2515–2518
   PubMedGoogle Scholar
• Nowell PC. (1960). Phytohemagglutinin: An initiator of mitosis in cultures of normal human leukocytes. Cancer Res, 20, 462–466
   PubMed Web of Science ®Google Scholar
• Nunes ES, Souza MA, Vaz AF, Silva TG, Aguiar JS, Batista AM, Guerra MM, Guarnieri MC, Coelho LC, Correia MT. (2012). Cytotoxic effect and apoptosis induction by Bothrops leucurus venom lectin on tumor cell lines. Toxicon, 59, 667–671
   PubMed Web of Science ®Google Scholar
• O’Keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Mori T, Blakeslee D, Buckheit R, Boyd MR. (2003). Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin. Antimicrob Agents Chemother, 47, 2518–2525
   PubMed Web of Science ®Google Scholar
• Oh-hora M, Rao A. (2008). Calcium signaling in lymphocytes. Curr Opin Immunol, 20, 250–258
   PubMed Web of Science ®Google Scholar
• Okamoto R, Hori K, Miyazawa K, Ito K. (1990). Isolation and characterization of a new hemagglutinin from the red alga Gracilaria bursa-pastoris. Experientia, 46, 975–977
   PubMedGoogle Scholar
• Oliveira MD, Andrade CA, Santos-Magalhães NS, Coelho LC, Teixeira JA, Carneiro-da-Cunha MG, Correia MT. (2008). Purification of a lectin from Eugenia uniflora L. seeds and its potential antibacterial activity. Lett Appl Microbiol, 46, 371–376
   PubMed Web of Science ®Google Scholar
• Osman N, Ley SC, Crumpton MJ. (1992). Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes. Eur J Immunol, 22, 2995–3000
   PubMedGoogle Scholar
• Pahlavani MA, Harris MD, Richardson A. (1998). Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats. Cell Immunol, 185, 39–48
   PubMedGoogle Scholar
• Paiva PMG, Gomes FS, Napoleao TH, Sa RA, Correia MTS, Coelho LCBB. (2010). Antimicrobial activity of secondary metabolites and lectins from plants. In: Mendez-Vilas A, ed. Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology. Spain: Formatex Research Center, 396–406
   Google Scholar
• Palacios MG, Cunnick JE. In vitro proliferation assay for lymphocyte function. Available: Ccoon.myweb.usf.edu/ecoimmunology.org/In_vitro_Lymphocyte_Proliferation_Assay.html. Accessed on 14 May 2012
   Google Scholar
• Palutke M, KuKuruga D, Tabaczka P. (1987). A flow cytometric method for measuring lymphocyte proliferation directly from tissue culture plates using Ki-67 and propidium iodide. J Immunol Methods, 105, 97–105
   PubMedGoogle Scholar
• Panchak LV, Antonyuk VO. (2011). Purification of a lectin from fruit bodies of Lactarius pergamenus (Fr.) Fr. and studies of its properties. Biochemistry Mosc, 76, 438–449
   PubMedGoogle Scholar
• Pandolfino ER, Namen AE, Munske GR, Magnuson JA. (1983). A comparison of the cell-binding characteristics of the mitogenic and nonmitogenic lectins from lima beans. J Biol Chem, 258, 9203–9207
   PubMed Web of Science ®Google Scholar
• Pani G, Colavitti R, Borrello S, Galeotti T. (2000). Endogenous oxygen radicals modulate protein tyrosine phosphorylation and JNK-1 activation in lectin-stimulated thymocytes. Biochem J, 347 Pt 1, 173–181
   PubMedGoogle Scholar
• Patel HR, Gelfand EW. (1996). DNA-binding phosphoproteins induced after T cell activation: Effects of cyclosporin A. Cell Signal, 8, 253–261
   PubMedGoogle Scholar
• Pineau N, Aucouturier P, Brugier JC, Preud’homme JL. (1990). Jacalin: a lectin mitogenic for human CD4 T lymphocytes. Clin Exp Immunol, 80, 420–425
   PubMed Web of Science ®Google Scholar
• Pujari R, Nagre NN, Chachadi VB, Inamdar SR, Swamy BM, Shastry P. (2010). Rhizoctonia bataticola lectin (RBL) induces mitogenesis and cytokine production in human PBMC via p38 MAPK and STAT-5 signaling pathways. Biochim Biophys Acta, 1800, 1268–1275
   PubMedGoogle Scholar
• Rana T, Bera AK, Das S, Bhattacharya D, Pan D, Bandyopadhyay S, Mondal DK, Samanta S, Bandyopadhyay S, Das SK. (2012). Pleurotus florida lectin normalizes duration dependent hepatic oxidative stress responses caused by arsenic in rat. Exp Toxicol Pathol, 64, 665–671
   PubMedGoogle Scholar
• Rao A, Luo C, Hogan PG. (1997). Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol, 15, 707–747
   PubMed Web of Science ®Google Scholar
• Reed JC, Robb RJ, Greene WC, Nowell PC. (1985). Effect of wheat germ agglutinin on the interleukin pathway of human T lymphocyte activation. J Immunol, 134, 314–323
   PubMedGoogle Scholar
• Romagnani S. (1999). Th1/Th2 cells. Inflamm Bowel Dis, 5, 285–294
   PubMed Web of Science ®Google Scholar
• Rosenfeld R, Bangio H, Gerwig GJ, Rosenberg R, Aloni R, Cohen Y, Amor Y, Plaschkes I, Kamerling JP, Maya RB. (2007). A lectin array-based methodology for the analysis of protein glycosylation. J Biochem Biophys Methods, 70, 415–426
   PubMedGoogle Scholar
• Rosenzweig WD, Ackroyd D. (1983). Binding characteristics of lectins involved in the trapping of nematodes by fungi. Appl Environ Microbiol, 46, 1093–1096
   PubMedGoogle Scholar
• Ross C, Vreeland V, Waite JH, Jacobs RS. (2005). Rapid assembly of a wound plug: Stage one of a two-stage wound repair mechanism in the unicellular chlorophyte Dasycladus vermicularis (chlorophyceae). J Phycol, 41, 46–54
   Google Scholar
• Rott O, Charreire J, Cash E. (1996). Influenza A virus hemagglutinin is a B cell-superstimulatory lectin. Med Microbiol Immunol, 184, 185–193
   PubMedGoogle Scholar
• Roy S, Chapin RB, Cain KJ, Charboneau RG, Ramakrishnan S, Barke RA. (1997). Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes. Cell Immunol, 179, 1–9
   PubMedGoogle Scholar
• Ruddon RW, Weisenthal LM, Lundeen DE, Bessler W, Goldstein IJ. (1974). Stimulation of mitogenesis in normal and leukemic human lymphocytes by divalent and tetravalent lima bean lectins. Proc Natl Acad Sci USA, 71, 1848–1851
   PubMedGoogle Scholar
• Rusterholz C, Henrioud PC, Nabholz M. (1999). Interleukin-2 (IL-2) regulates the accessibility of the IL-2-responsive enhancer in the IL-2 receptor alpha gene to transcription factors. Mol Cell Biol, 19, 2681–2689
   PubMedGoogle Scholar
• Di Sabato G, Hall JM, Thompson L. (1987). T cell mitogens and polyclonal B cell activators. Meth Enzymol, 150, 3–17
   PubMedGoogle Scholar
• Sad S, Mosmann TR. (1995). Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines. J Exp Med, 182, 1505–1515
   PubMed Web of Science ®Google Scholar
• Sareneva T, Matikainen S, Vanhatalo J, Melén K, Pelkonen J, Julkunen I. (1998). Kinetics of cytokine and NFAT gene expression in human interleukin-2-dependent T lymphoblasts stimulated via T-cell receptor. Immunology, 93, 350–357
   PubMedGoogle Scholar
• Sasaki DT, Dumas SE, Engleman EG. (1987). Discrimination of viable and non-viable cells using propidium iodide in two color immunofluorescence. Cytometry, 8, 413–420
   PubMedGoogle Scholar
• Sato Y, Hirayama M, Morimoto K, Yamamoto N, Okuyama S, Hori K. (2011). High mannose-binding lectin with preference for the cluster of alpha1-2-mannose from the green alga Boodlea coacta is a potent entry inhibitor of HIV-1 and influenza viruses. J Biol Chem, 286, 19446–19458
   PubMed Web of Science ®Google Scholar
• Serfling E, Berberich-Siebelt F, Chuvpilo S, Jankevics E, Klein-Hessling S, Twardzik T, Avots A. (2000). The role of NF-AT transcription factors in T cell activation and differentiation. Biochim Biophys Acta, 1498, 1–18
   PubMedGoogle Scholar
• Sharabi Y, Gilboa-Garber N. (1979). Mitogenic stimulation of human lymphocytes by Pseudomonas aeruginosa galactosephilic lectins. FEMS Lett, 5, 273–276
   Google Scholar
• Sharabi Y, Gilboa-Garber N. (1980). Interactions of Pseudomonas aeruginosa hemagglutinins with Euglena gracilis, Chlamydomonas reinhardi, and Tetrahymena pyriformis. J Protozool, 27, 80–86
   PubMedGoogle Scholar
• Sharon N, Lis H. (1972). Lectins: Cell-agglutinating and sugar-specific proteins. Science, 177, 949–959
   PubMed Web of Science ®Google Scholar
• Sharon N, Lis H. (2004). History of lectins: From hemagglutinins to biological recognition molecules. Glycobiology, 14, 53R–62R
   PubMed Web of Science ®Google Scholar
• Sharon N. (1984). Surface carbohydrates and surface lectins are recognition determinants in phagocytosis. Immunol Today, 5, 143–147
   PubMedGoogle Scholar
• Sharon N. (1987). Bacterial lectins, cell-cell recognition and infectious disease. FEBS Lett, 217, 145–157
   PubMed Web of Science ®Google Scholar
• She QB, Ng TB, Liu WK. (1998). A novel lectin with potent immunomodulatory activity isolated from both fruiting bodies and cultured mycelia of the edible mushroom Volvariella volvacea. Biochem Biophys Res Commun, 247, 106–111
   PubMed Web of Science ®Google Scholar
• Singh J, Singh J, Kamboj SS. (2004). A novel mitogenic and antiproliferative lectin from a wild cobra lily, Arisaema flavum. Biochem Biophys Res Commun, 318, 1057–1065
   PubMedGoogle Scholar
• Singh R, Tiwari IM, Jagadeesh HM, Kansal R, Gupta RN, Koundal KR, Saini R. (2012). Isolation of lectin gene and development of resistant Nicotiana tabacum L. against Spodoptera litura. Indian J Biotechnol, 11, 134–141
   Google Scholar
• Singh RS, Bhari R, Kaur HP. (2010). Mushroom lectins: Current status and future perspectives. Crit Rev Biotechnol, 30, 99–126
   PubMed Web of Science ®Google Scholar
• Singh RS, Bhari R, Singh J, Tiwary AK. (2011a). Purification and characterization of a mucin-binding mycelial lectin from Aspergillus nidulans with potent mitogenic activity. World J Microbiol Biotechnol, 27, 547–554
   Google Scholar
• Singh RS, Tiwary AK, Kennedy JF. (1999). Lectins: Sources, activities, and applications. Crit Rev Biotechnol, 19, 145–178
   Web of Science ®Google Scholar
• Singh RS, Bhari R, Kaur HP. (2011b). Current trends of lectins from microfungi. Crit Rev Biotechnol, 31, 193–210
   PubMed Web of Science ®Google Scholar
• Smith KA. (2006). The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs. Med Immunol, 5, 3
   PubMedGoogle Scholar
• Snell GD. (1978). T cells, T cells recognition structures, and the major histocompatibility complex. Immunol Rev, 38, 3–69
   PubMed Web of Science ®Google Scholar
• Sommer F, Klotz T, Steinritz D, Schmidt A, Addicks K, Engelmann U, Bloch W. (2002). MAP kinase ½ (Erk ½) and serine/threonine specific protein kinase Akt/PKB expression and activity in the human corpus cavernosum. Int J Impot Res, 14, 217–225
   PubMed Web of Science ®Google Scholar
• Sottong PR, Rosebrock JA, Britz JA, Kramer TR. (2000). Measurement of T-lymphocyte responses in whole-blood cultures using newly synthesized DNA and ATP. Clin Diagn Lab Immunol, 7, 307–311
   PubMedGoogle Scholar
• Stillmark H. (1888). Ricin, a toxic enzyme from seeds of Ricinus communis L. and some other Euphorbiaceae. Dissertation, Medical School of Dorpat, Estonia
   Google Scholar
• Stojanovic MM, Zivkovic IP, Petrusic VZ, Kosec DJ, Dimitrijevic RD, Jankov RM, Dimitrijevic LA, Gavrovic-Jankulovic MD. (2010). In vitro stimulation of Balb/c and C57 BL/6 splenocytes by a recombinantly produced banana lectin isoform results in both a proliferation of T cells and an increased secretion of interferon-gamma. Int Immunopharmacol, 10, 120–129
   PubMedGoogle Scholar
• Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. (1994). JNK is involved in signal integration during costimulation of T lymphocytes. Cell, 77, 727–736
   PubMed Web of Science ®Google Scholar
• Sunder-Plassmann R, Reinherz EL. (1998). A p56lck-independent pathway of CD2 signaling involves Jun kinase. J Biol Chem, 273, 24249–24257
   PubMedGoogle Scholar
• Suttisrisung S, Senapin S, Withyachumnarnkul B, Wongprasert K. (2011). Identification and characterization of a novel legume-like lectin cDNA sequence from the red marine algae Gracilaria fisheri. J Biosci, 36, 833–843
   PubMedGoogle Scholar
• Suzuki S, Kupsch J, Eichmann K, Saizawa MK. (1992). Biochemical evidence of the physical association of the majority of CD3 delta chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes. Eur J Immunol, 22, 2475–2479
   PubMedGoogle Scholar
• Suzuki T, Sugiyama K, Hirai H, Ito H, Morita T, Dohra H, Murata T, Usui T, Tateno H, Hirabayashi J, Kobayashi Y, Kawagishi H. (2012). Mannose-specific lectin from the mushroom Hygrophorus russula. Glycobiology, 22, 616–629
   PubMedGoogle Scholar
• Swamy BM, Hegde GV, Naik RS, Inamdar SR. (2001). T-antigen binding lectin from the phytopathogenic fungus Sclerotium rolfsii. In: Thorkild C, Bog-Hansen TC, eds. Lectins, Biology, Biochemistry, Clinical Biochemistry. Hellerup, Belgium: Textop, 45–55
   Google Scholar
• Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. (2003). Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol, 21, 713–758
   PubMed Web of Science ®Google Scholar
• Sze SC, Ho JC, Liu WK. (2004). Volvariella volvacea lectin activates mouse T lymphocytes by a calcium dependent pathway. J Cell Biochem, 92, 1193–1202
   PubMed Web of Science ®Google Scholar
• Taimi M, Dornand J, Nicolas M, Marti J, Favero J. (1994). Involvement of CD4 in interleukin-6 secretion by U937 monocytic cells stimulated with the lectin jacalin. J Leukoc Biol, 55, 214–220
   PubMedGoogle Scholar
• Tamma SM, Kalyanaraman VS, Pahwa S, Dominguez P, Modesto RR. (2003). The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells. J Leukoc Biol, 73, 682–688
   PubMedGoogle Scholar
• Tateno H, Saneyoshi A, Ogawa T, Muramoto K, Kamiya H, Saneyoshi M. (1998). Isolation and characterization of rhamnose-binding lectins from eggs of steelhead trout (Oncorhynchus mykiss) homologous to low density lipoprotein receptor superfamily. J Biol Chem, 273, 19190–19197
   PubMed Web of Science ®Google Scholar
• Taylor JH, Woods PS, Hughes WL. (1957). The organization and duplication of chromosomes as revealed by autoradiographic studies using tritium-labeled thymidinee. Proc Natl Acad Sci USA, 43, 122–128
   PubMed Web of Science ®Google Scholar
• Teague TK, Munn L, Zygourakis K, McIntyre BW. (1993). Analysis of lymphocyte activation and proliferation by video microscopy and digital imaging. Cytometry, 14, 772–782
   PubMedGoogle Scholar
• Thomas PA. (2003). Current perspectives on ophthalmic mycoses. Clin Microbiol Rev, 16, 730–797
   PubMed Web of Science ®Google Scholar
• Todd SC, Lipps SG, Crisa L, Salomon DR, Tsoukas CD. (1996). CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation. J Exp Med, 184, 2055–2060
   PubMed Web of Science ®Google Scholar
• Tonks NK, Charbonneau H, Diltz CD, Fischer EH, Walsh KA. (1988). Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase. Biochemistry, 27, 8695–8701
   PubMedGoogle Scholar
• Tripathi S, Maiti TK. (2003a). Efficiency of heat denatured lectins from Abrus precatorius as immunoadjuvants. Food Agric Immunol, 15, 279–287
   Web of Science ®Google Scholar
• Tripathi S, Maiti TK. (2003b). Stimulation of murine macrophages by native and heat-denatured lectin from Abrus precatorius. Int Immunopharmacol, 3, 375–381
   PubMed Web of Science ®Google Scholar
• Tripathi S, Maiti TK. (2005). Immunomodulatory role of native and heat denatured agglutinin from Abrus precatorius. Int J Biochem Cell Biol, 37, 451–462
   PubMed Web of Science ®Google Scholar
• Trowbridge IS, Thomas ML. (1994). CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu Rev Immunol, 12, 85–116
   PubMed Web of Science ®Google Scholar
• Truneh A, Albert F, Golstein P, Schmitt-Verhulst AM. (1985). Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature, 313, 318–320
   PubMed Web of Science ®Google Scholar
• Tsuda M. (1979). Purification and characterization of a lectin from the mushroom, Flammulina veltipes. J Biochem, 86, 1463–1468
   PubMed Web of Science ®Google Scholar
• UIS/WHO Report. (1988). Laboratory investigations in clinical immunology methods, pitfalls, and chemical medications. Clin Exp lmmunol, 74, 494–503
   PubMedGoogle Scholar
• Vaheri A, Ruoslahti E, Sarvas M, Nurminen M. (1973). Mitogenic effect by lipopolysaccharide and pokeweed lectin on density-inhibited chick embryo fibroblasts. J Exp Med, 138, 1356–1364
   PubMedGoogle Scholar
• Valentino L, Pierre J. (2006). JAK/STAT signal transduction: Regulators and implication in hematological malignancies. Biochem Pharmacol, 71, 713–721
   PubMed Web of Science ®Google Scholar
• Vasta GR, Marchalonis JJ, Decker JM. (1986). Binding and mitogenic properties of a galactosyl-specific lectin from the tunicate Didemnum candidum for murine thymocytes and splenocytes. J Immunol, 137, 3216–3223
   PubMedGoogle Scholar
• Vermassen T, Speeckaert MM, Lumen N, Rottey S, Delanghe JR. (2012). Glycosylation of prostate specific antigen and its potential diagnostic applications. Clin Chim Acta, 413, 1500–1505
   PubMed Web of Science ®Google Scholar
• Vig M, Kinet JP. (2009). Calcium signaling in immune cells. Nat Immunol, 10, 21–27
   PubMed Web of Science ®Google Scholar
• Walzel H, Schulz U, Neels P, Brock J. (1999). Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. Immunol Lett, 67, 193–202
   PubMedGoogle Scholar
• Wang H, Ng TB, Liu Q. (2002). Isolation of a new heterodimeric lectin with mitogenic activity from fruiting bodies of the mushroom Agrocybe cylindracea. Life Sci, 70, 877–885
   PubMedGoogle Scholar
• Wang H, Ng TB, Liu Q. (2003). A novel lectin from the wild mushroom Polyporus adusta. Biochem Biophys Res Commun, 307, 535–539
   PubMedGoogle Scholar
• Wang H, Ng TB. (2005). First report of an arabinose-specific fungal lectin. Biochem Biophys Res Commun, 337, 621–625
   PubMedGoogle Scholar
• Wang HX, Ng TB, Ooi VEC. (1998). Lectins from mushrooms. Mycol Res, 102, 897–906
   Google Scholar
• Wang HX, Ng TB. (2001). Examination of lectins, polysaccharopeptide, polysaccharide, alkaloid, coumarin and trypsin inhibitors for inhibitory activity against human immunodeficiency virus reverse transcriptase and glycohydrolases. Planta Med, 67, 669–672
   PubMed Web of Science ®Google Scholar
• Wells V, Mallucci L. (1991). Identification of an autocrine negative growth factor: mouse beta-galactoside-binding protein is a cytostatic factor and cell growth regulator. Cell, 64, 91–97
   PubMedGoogle Scholar
• Whitehurst CE, Boulton TG, Cobb MH, Geppert TD. (1992). Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta-phorbol 12-myristate 13-acetate-induced phosphorylation and activation. J Immunol, 148, 3230–3237
   PubMedGoogle Scholar
• Wimer BM. (1990). Characteristics of PHA-L4, the mitogenic isolectin of phytohemagglutinin, as an ideal biologic response modifier. Mol Biother, 2, 4–17
   PubMedGoogle Scholar
• Wimer BM. (2003). Curative potential of foremost mitogen applications. Cancer Biother Radiopharm, 18, 903–916
   PubMedGoogle Scholar
• Witherden DA, Boismenu R, Havran WL. (2000). CD81 and CD28 costimulate T cells through distinct pathways. J Immunol, 165, 1902–1909
   PubMedGoogle Scholar
• Wright MD, Tomlinson MG. (1994). The ins and outs of the transmembrane 4 superfamily. Immunol Today, 15, 588–594
   PubMed Web of Science ®Google Scholar
• Wu J, Zeng YX, Hirokawa K. (1999). Signal pathway of mitogen-induced Ca2+-activated K+ currents in young and aged T-cell clones of C57BL/6 mice. Cell Signal, 11, 391–398
   PubMedGoogle Scholar
• Yachie A, Hernandez D, Blaese RM. (1987). T3-T cell receptor (Ti) complex-independent activation of T cells by wheat germ agglutinin. J Immunol, 138, 2843–2847
   PubMedGoogle Scholar
• Yakura H. (1994). The role of protein tyrosine phosphatases in lymphocyte activation and differentiation. Crit Rev Immunol, 14, 311–336
   PubMedGoogle Scholar
• Yamaoka K, Ingendoh A, Tsubuki S, Nagai Y, Sanai Y. (1996). Structural and functional characterization of a novel tumor-derived rat galectin-1 having transforming growth factor (TGF) activity: The relationship between intramolecular disulfide bridges and TGF activity. J Biochem, 119, 878–886
   PubMedGoogle Scholar
• Yamaoka K, Ohno S, Kawasaki H, Suzuki K. (1991). Overexpression of a beta-galactoside binding protein causes transformation of BALB3T3 fibroblast cells. Biochem Biophys Res Commun, 179, 272–279
   PubMedGoogle Scholar
• Yao D, Pan S, Zhou M. (2012). Structural characterization and antitumor and mitogenic activity of a lectin from the gill of bighead carp (Aristichthys nobilis). Fish Physiol Biochem, doi 10.1007/s10695–012–9678–1
   PubMedGoogle Scholar
• Yoon KS, Lee KP, Klochkova TA, Kim GH. (2008). Molecular characterization of the lectin, Bryohealin, involved in protoplast regeneration of the marine alga Bryopsis plumosa (Chlorophyta). J Phycol, 44, 103–112
   PubMed Web of Science ®Google Scholar
• Zeng Z, Hincapie M, Pitteri SJ, Hanash S, Schalkwijk J, Hogan JM, Wang H, Hancock WS. (2011). A proteomics platform combining depletion, multi-lectin affinity chromatography (M-LAC), and isoelectric focusing to study the breast cancer proteome. Anal Chem, 83, 4845–4854
   PubMed Web of Science ®Google Scholar
• Zhang G, Sun J, Wang H, Ng TB. (2010). First isolation and characterization of a novel lectin with potent antitumor activity from a Russula mushroom. Phytomedicine, 17, 775–781
   PubMed Web of Science ®Google Scholar
• Zhao S, Zhao Y, Li S, Zhao J, Zhang G, Wang H, Ng TB. (2010). A novel lectin with highly potent antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the edible wild mushroom Russula delica. Glycoconj J, 27, 259–265
   PubMed Web of Science ®Google Scholar
• Zheng S, Li C, Ng TB, Wang HX. (2007). A lectin with mitogenic activity from the edible wild mushroom Boletus edulis. Process Biochem, 42, 1620–1624
   Google Scholar
• Zmuidzinas A, Mamon HJ, Roberts TM, Smith KA. (1991). Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells. Mol Cell Biol, 11, 2794–2803
   PubMed Web of Science ®Google Scholar