Kainic Acid: The Neurotoxic Breakthrough

References

• Ceccarelli B., Clementi F. Advances in Cytopharmacology. Neurotoxins: Tools in Neurobiology. Raven Press, New York 1979; Vol. 3
   Google Scholar
• Takemoto T. Isolation and structural identification of naturally occurring excitatory amino acids. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 7
   Google Scholar
• Shinozaki H. Discovery of novel actions of kainic acid and related compounds. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 17
   Google Scholar
• Watkins J. C. Excitatory amino acids. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 37
   Google Scholar
• Johnston G. A. R., Curtis D. R., de Groat W. C., Duggan A. W. Central actions of ibotenic acid and muscimol. Biochem. Pharmacol. 1968; 17: 2488
   PubMed Web of Science ®Google Scholar
• Olney J. W. Neurotoxicity of excitatory amino acids. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 95
   Google Scholar
• Lucas D. R., Newhouse J. P. The toxic effect of sodium L-glutamate on the inner layers of the retina. A.M.A. Arch. Opthalmol. 1957; 58
   PubMedGoogle Scholar
• McGeer P. L., McGeer E. G., Hattori T. Kainic acid as a tool in neurobiology. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 123
   Google Scholar
• Biziere K., Coyle J. T. Effects of kainic acid on ion distribution and ATP levels of striatal slices incubated, in vitro. J. Neurochem. 1978; 31: 513
   PubMedGoogle Scholar
• McGeer P. L., McGeer E. G. Amino acid neurotransmitters. Basic Neurochemistry, 3rd ed., G. J. Siegel, R. W. Albers, R. Katzman, B. W. Agranoff. Little, Brown, New York 1981, chap. 12
   Google Scholar
• Johnston G. A. R. Central nervous system receptors for glutamic acid. Glutamic Acid: Advances in Biochemistry and Physiology, L. J. Filer, S. Garattini, M. R. Kare, W. A. Reynolds, R. J. Wurtman. Raven Press, New York 1979; 177
   Google Scholar
• McGeer E. G., McGeer P. L., Singh K. Kainic acid-induced degeneration of neostriatal neurons: dependency upon cortico-striatal tract. Brain Res. 1978; 139: 381
   PubMed Web of Science ®Google Scholar
• Biziere K., Coyle J. T. Influence of cortico-striatal afferents on striatal kainic acid neurotoxicity. Neurosci. Lett. 1978; 8: 303
   PubMed Web of Science ®Google Scholar
• Biziere K., Thompson H., Coyle J. T. Characterization of specific high-affinity binding sites for L-[3H]glutamate acid in rat brain membranes. Brain Res. 1980; 183: 421
   PubMedGoogle Scholar
• Vincent S. R., McGeer E. G. Kainic acid binding to membranes of striatal neurons. Life Sci. 1979; 24: 265
   PubMedGoogle Scholar
• Schwarcz R., Fuxe K. 3H-kainic acid binding: relevance for evaluating the neurotoxicity of kainic acid. Life Sci. 1979; 24: 1471
   PubMed Web of Science ®Google Scholar
• Biziere K., Coyle J. T. Localization of receptors for kainic acid on neurons in the inner nuclar layer of retina. Neuropharmacology 1979; 18: 409
   PubMedGoogle Scholar
• Köhler C., Schwarcz R., Fuxe J. Perforant path transections protect hippocampal granule cells from kainate lesion. Neurosci. Lett. 1978; 10: 241
   PubMedGoogle Scholar
• Streit P., Stella M., Cuenod M. Kainate-induced lesion in the optic tectum: dependency upon optic nerve afferents or glutamate. Brain Res. 1980; 187: 47
   PubMedGoogle Scholar
• Malthe-Sorenssen D., Odden E., Walaas I. Selective destruction by kainic acid of neurons innervated by putative glutamatergic afferents in septum and nucleus of the diagonal band. Brain Res. 1980; 182: 461
   PubMedGoogle Scholar
• Köhler C., Schwarcz R., Fuxe K. Hippocampal lesions indicate differences between the excitotoxic properties of acidic amino acids. Brain Res. 1979; 175: 366
   PubMed Web of Science ®Google Scholar
• Schwarcz R., Hökfelt T., Fuxe K., Jonsson G., Goldstein M., Terenius L. Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study. Exp. Brain Res. 1979; 37: 199
   PubMedGoogle Scholar
• Nadler J. V., Perry B. W., Cotman C. W. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature 1978; 271: 676
   PubMedGoogle Scholar
• Ben-Ari Y., Tremblay E., Ottersen O. P., Naquet R. Evidence suggesting secondary epileptogenic lesions after kainic acid: pretreatment with diazepam reduces distant but not local brain damage. Brain Res. 1979; 165: 362
   PubMed Web of Science ®Google Scholar
• Crawford I. L., Wooten W. C.A. Kainic acid elicits electrographic epileptiform activity after central and parenteral administration to awake rats. Soc. Neurosci. Abstr. 1979; 5: 191
   Google Scholar
• Nadler J. V., Cuthbertson G. J. Kainic acid neurotoxicity toward hippocampus: dependence on specific excitatory pathways. Soc. Neurosci. Abstr. 1979; 5: 280
   Google Scholar
• Fuller T. A., Olney J. W. Morphine enhances and diazepam suppresses the neurotoxicity of systemically administered kainic acid. Soc. Neurosci. Abstr. 1979; 5: 556
   Google Scholar
• Scherer-Singler U., McGeer E. G. Distribution and persistence of kainic acid in brain. Life Sci. 1979; 24: 1015
   PubMedGoogle Scholar
• McGeer P. L., McGeer E. G. Kainic acid as a selective lesioning agent. Glutamate: Transmitter in the CNS, P. J. Roberts, J. Storm-Mathisen, G. R.S. Johnston. John Wiley & Sons, New York, in press
   Google Scholar
• Masterton R. B., Glenderring K. K., Hutson K. A. Preservation of trapezoid body fibers after biochemical ablation of superior olives with kainic acid. Brain Res. 1979; 173: 156
   PubMedGoogle Scholar
• Assaf S. Y., Miller J. J. A comparison of the effects of electrolytic and kainic acid-induced lesions of the septal area on hippocampal electrical activity. Can. Fed. Biol. Soc. 1978
   Google Scholar
• Herndon R. M., Coyle J. T. Selective destruction of neurons by a transmitter agonist. Science 1977; 198: 71
   PubMedGoogle Scholar
• Colonnier M., Steriade M., Landry P. Selective resistance of sensory cells of the mesencephalic trigeminal to kainic acid-induced lesions. Brain Res. 1979; 172: 552
   PubMedGoogle Scholar
• Lund J. P., de Montigny C. Rat trigeminal mesencephalic neurons are resistant to both excitatory and neurotoxic actions of kainic acid. Soc. Neurosci. Abstr. 1979; 5: 592
   Google Scholar
• Hammond C., Feger J., Bioulac B., Souteyrand J. P. Experimental hemiballism in the monkey produced by unilateral kainic acid lesion in corpus Luysii. Brain Res. 1979; 171: 577
   PubMedGoogle Scholar
• Coyle J. T., McGeer E. G., McGeer P. L., Schwarez R. Neostriatal injections: a model for Huntington's chorea. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 139
   Google Scholar
• Hattori T., McGeer E. G. Fine structural changes in the rat striatum after local injections of kainic acid. Brain Res. 1977; 129: 174
   PubMedGoogle Scholar
• Fibiger H. C. Kainic acid lesions of the striatum: a pharmacological and behavioral model of Huntington's disease. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 161
   Google Scholar
• Hruska R. E., Silbergeld E. K. Abnormal locomotion in rats after bilateral intrastriatal injection of kainic acid. Life Sci. 1979; 25: 181
   PubMed Web of Science ®Google Scholar
• Sanberg P. R., Fibiger H. C. Body weight, feeding, and drinking behaviors in rats with kainic acid-induced lesions of striatal neurons—with a note on body weight symptomatology in Huntington's disease. Exp. Neurol. 1979; 66: 444
   PubMedGoogle Scholar
• Sanberg P. R., Lehmann J., Fibiger H. C. Impaired learning and memory after kainic acid lesions of the striatum: a behavioral model of Huntington's disease. Brain Res. 1978; 149: 546
   PubMed Web of Science ®Google Scholar
• Divac I., Markowitsch H. J., Pritzel M. Behavioral and anatomical consequences of small intrastriatal injections of kainic acid in the rat. Brain Res. 1978; 151: 523
   PubMed Web of Science ®Google Scholar
• Sanberg P. R., Lehmann J., Fibiger H. C. Sedative effects of apomorphine in an animal model of Huntington's disease. Arch. Neurol. 1979; 36: 349
   PubMedGoogle Scholar
• Borison R. L., Diamond B. I. Kainic acid model predicts therapeutic agents in Huntington's chorea. Ann. Neurol. 1979; 6: 149
   Google Scholar
• Ando N., Gold B. I., Bird E. D., Roth R. H. Regional brain levels of γ-hydroxybutyrate in Huntington's disease. J. Neurochem. 1979; 32: 617
   PubMedGoogle Scholar
• Ando N., Simon J. R., Roth R. H. Inverse relationship between GABA and γ-hydroxybutyrate levels in striatum of rat injected with kainic acid. J. Neurochem. 1979; 32: 623
   PubMedGoogle Scholar
• Neckers L. M., Neff N. H., Wyatt R. J. Increased serotonin turnover in corpus striatum following an injection of kainic acid: evidence for neuronal feedback regulation of synthesis. Naunyn-Schmiedebergs Arch. Pharmacol. 1979; 306: 173
   PubMedGoogle Scholar
• Schwarcz R., Fuxe K., Hökfelt T., Terenius L., Goldstein M. Effects of chronic striatal kainate lesions on some dopaminergic parameters and enkephalin immunoreactive neurons in the basal ganglia. J. Neurochem. 1980; 34: 772
   PubMedGoogle Scholar
• Fillion G., Beaudoin D., Rousselle J. C., Deniau J. M., Fillion M. P., Dray F., Jacob J. Decrease of [+H]-5-HT high affinity binding and 5-HT adenylate cyclase activation after kainic acid lesion in rat brain striatum. J. Neurochem. 1979; 33: 567
   PubMedGoogle Scholar
• Fields J. Z., Reisine T. D., Yamamura H. I. Loss of striatal dopaminergic receptors after intrastriatal kainic acid. Life Sci. 1978; 23: 569
   PubMedGoogle Scholar
• Sperk G., Schlogl E. Reduction of number of benzodiazepine binding sites in the caudate nucleus of the rat after kainic acid injections. Brain Res. 1979; 170: 563
   PubMedGoogle Scholar
• Möhler H., Okada T. The benzodiazapine receptor in normal and pathological human brain. Br. J. Psychiatr. 1978; 133: 261
   PubMed Web of Science ®Google Scholar
• Henke H. Kainic acid binding in human caudate nucleus: effect of Huntington's disease. Neurosci. Lett. 1979; 14: 247
   PubMedGoogle Scholar
• Beaumont K., Maurin Y., Reisine T. D., Fields J. Z., Spokes E., Bird E. D., Yamamura H. I. Huntington's disease and its animal model. Alterations in kainic acid binding. Life Sci. 1979; 24: 809
   PubMedGoogle Scholar
• Zaczek R., Schwarcz R., Coyle J. T. Long-term sequelae of striatal kainate lesion. Brain Res. 1978; 152: 626
   PubMedGoogle Scholar
• Zahniser N. R., Minneman K. P., Molinoff P. B. Persistence of β-adrenergic receptors in rat striatum following kainic acid administration. Brain Res. 1979; 178: 589
   PubMedGoogle Scholar
• Enna S. J., Bird E. D., Bennett J. P., Bylund D. B., Yamamura H. I., Iversen L. L., Synder S. Huntington's chorea: changes in neurotransmitter receptors in the brain. N. Engl. J. Med. 1976; 294: 1305
   PubMedGoogle Scholar
• Lorente de Nó R. Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system. J. Psychol. Neurol. 1934; 46: 113
   Google Scholar
• Nadler J. V., Perry B. W., Cotman C. W. Preferential vulnerability of hippocampus to intraventricular kainic acid. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 219
   Google Scholar
• Lanthorn T., Isaacson R. L. Studies of kainate-induced wet-dog shakes in the rat. Life Sci. 1978; 22: 171
   PubMedGoogle Scholar
• Hjorth-Simonsen A. Some intrinsic connections of the hippocampus in the rat: an experimental analysis. J. Comp. Neurol. 1973; 147: 145
   PubMed Web of Science ®Google Scholar
• Fonnum F., Walaas I. The effect of intrahippocampal kainic acid injections and surgical lesions on neurotransmitters in hippocampus and septum. J. Neurochem. 1978; 31: 1173
   PubMed Web of Science ®Google Scholar
• Schwarcz R., Zaczek R., Coyle J. T. Microinjection of kainic acid into the rat hippocampus. Eur. J. Pharmacol. 1978; 50: 209
   PubMed Web of Science ®Google Scholar
• Nadler J. V., Perry B. W., Cotman C. W. Selective reinnervation of hippocampal area CA 1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. Brain Res. 1980; 182: 1
   PubMedGoogle Scholar
• Collins R. C., McLean M., Lothman E., Klunk W., Olney J. Kainic acid causes limbic seizures
   Google Scholar
• Ben-Ari Y., Lagowska J., Tremblay E., Le Gal La Salle G. A new model of local status epilepticus: intra-amygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures. Brain Res. 1979; 163: 176
   PubMedGoogle Scholar
• Boyko W. J., Galabru C. K., McGeer E. G., McGeer P. L. Thalamic injections of kainic acid produce myocardial necrosis. Life Sci. 1979; 25: 87
   PubMedGoogle Scholar
• Chelly J., Kouyoumdjian J. C., Mouille P., Huchet A. M., Schmitt H. Effects of L-glutamic acid and kainic acid on central cardiovascular control. Eur. J. Pharmacol. 1979; 60: 91
   PubMedGoogle Scholar
• Olney J. W., Price M. T. Excitotoxic amino acids as neuroendocrine probes. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 239
   Google Scholar
• Simpson J. B., Routtenberg A. Subfornical organ: site of drinking elicitation by angiotensin II. Science 1973; 181: 1172
   PubMed Web of Science ®Google Scholar
• Costa E., Gessa G. L. Nonstriatal Dopaminergic Neurons. Raven Press, New York 1977; Vol. 16: 71
   Google Scholar
• McGeer P. L., Eccles Sir J. C., McGeer E. G. Promising peptides. Molecular Neurobiology of the Mammalian Brain. Plenum Press, New York 1978, chap. 10
   Google Scholar
• Nemeroff C. B., Lipton M. A., Kizer J. S. Models of neuroendocrine regulation: use of monosodium glutamate as an investigational tool. Dev. Neurosci. 1978; 1: 102
   PubMedGoogle Scholar
• Simon E. L., Gold R. M., Standish L. J., Pellett P. L. Axon-sparing lesioning technique: the use of monosodium-L-glutamate and other amino acids. Science 1977; 198: 515
   PubMedGoogle Scholar
• Olney J. W. Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science 1969; 164: 719
   PubMed Web of Science ®Google Scholar
• Cameron D. P., Poon T. K.-Y., Smith G. C. Effects of monosodium glutamate administration in the neonatal period on the diabetic syndrome in KK mice. Diabetologia 1976; 12: 621
   PubMedGoogle Scholar
• Walaas I., Fonnum F. The effect of parenteral glutamate treatment on the localization of neurotransmitters in the mediobasal hypothalamus. Brain Res. 1978; 153: 549
   PubMedGoogle Scholar
• Krieger D. T., Liotta A. S., Nicholson G., Kizer J. S. Brain ACTH and endorphin reduced in rats with monosodium glutamate-induced arcuate nuclear lesions. Nature 1979; 278: 562
   PubMed Web of Science ®Google Scholar
• Eskay R. L., Brownstein M. J., Long R. T. α-Melanocyte-stimulating hormone: reduction in adult rat brain after monosodium glutamate treatment of neonates. Science 1979; 205: 827
   PubMedGoogle Scholar
• Finley J. C. W., Grossman G. H., Dimeo P., Petrusz P. Somatostatin-containing neurons in the rat brain: widespread distribution revealed by immunocytochemistry after pretreatment with pronase. Am. J. Anat. 1978; 153: 483
   PubMedGoogle Scholar
• Coyle J. T., Biziere K., Schwarcz R. Neurotoxicity of excitatory amino acids in the neural retina. Kainic Acid as a Tool in Neurobiology, E. G. McGeer, J. W. Olney, P. L. McGeer. Raven Press, New York 1978; 177
   Google Scholar
• Lake N., Patel Y. C. Neurotoxic agents reduce retinal somatostatin. Brain Res. 1980; 181: 234
   PubMedGoogle Scholar
• Lund Karlsen R. The toxic effect of sodium glutamate and dl-α-aminoadipic acid on rat retina: changes in high affinity uptake of putative transmitters. J. Neurochem. 1978; 31: 1055
   PubMedGoogle Scholar
• Yazulla S., Kleinschmidt J. The effects of intraocular injection of kainic acid on the synaptic organization of the goldfish retina. Brain Res. 1980; 182: 287
   PubMed Web of Science ®Google Scholar
• Lund Karlsen R., Fonnum F. The toxic effects of sodium glutamate on rat retina: changes in putative transmitters and thier corresponding enzymes. J. Neurochem. 1976; 27: 1437
   PubMedGoogle Scholar
• Salceda R., Carabez A., Pacheco P., Pasantes-Morales H. Taurine levels, uptake and synthesizing enzyme activities in degenerated rat retina. Exp. Eye Res. 1979; 28: 137
   PubMedGoogle Scholar
• Cohen A. I., McDaniel M., Orr H. Absolute levels of some free amino acids in normal and biologically fractionated retinas. Invest. Ophthalmol. 1973; 12: 686
   PubMedGoogle Scholar
• McGeer E. G., McGeer P. L., Hattori T., Vincent S. R. Kainic acid neurotoxicity and Huntington's disease. Advances in Neurology, T. N. Chase, N. S. Wexler, A. Barbeau. Raven Press, New York 1979; Vol. 23: 577
   Google Scholar
• Sanburg C., personal communication
   Google Scholar