Studies on the Mechanism of Nephrotoxicity and Nephrocarcinogenicity of Halogenated Alkenes

References

• Hook J. B., McCormack K. M., Kluwe W. M. Biochemical mechanisms of nephrotoxicity. Rev. Biochem. Toxicol 1979; 1: 53
   Google Scholar
• Rush G. F., Smith J. H., Newton J. F., Hook J. B. Chemically induced nephrotoxicity: role of metabolic activation. CRC Crit. Rev. Toxicol. 1984; 13: 99
   Web of Science ®Google Scholar
• Lock E. A. Metabolic activation of halogenated chemicals and its relevance to nephrotoxicity. Nephrotoxicity in the Clinical and Experimental Situation, P. H. Bach, E. A. Lock. MTP Press, LancasterEngland 1987; 429
   Google Scholar
• Wolf C. R., Berry P. N., Nash J. A., Green T., Lock E. A. The role of microsomal and cytosolic glutathione-S-transferases in the conjugation of hexachloro-1,3-butadiene and its possible relevance to toxicity. J. Pharmacol. Exp. Ther. 1984; 228: 202
   PubMed Web of Science ®Google Scholar
• Odum J., Green T. The metabolism and nephrotoxicity of tetrafluoroethylene in the rat. Toxicol. Appl. Pharmacol. 1984; 76: 306
   PubMed Web of Science ®Google Scholar
• Wachstein M. Nephrotoxic action of dl-serine in the rat. Arch. Pathol. 1947; 43: 503
   Google Scholar
• Terracini B., Parker V. H. A pathological study on the toxicity ofS-dichlorovinyl-l-cysteine. Food Cosmet. Toxicol. 1965; 3: 67
   PubMedGoogle Scholar
• Jakoby W. B., Habig W. H. Glutathione transferases. Enzymatic Basis of Detoxication, W. B. Jakoby. Academic Press, New York 1980; Vol. II: 63
   Google Scholar
• Tate S. S. Enzymes of mercapturic acid formation. Enzymatic Basis of Detoxication, W. B. Jakoby. Academic Press, New York 1980; Vol. II: 95
   Google Scholar
• Rannug U., Sundvall A., Ramel C. The mutagenic effect of 1,2-dichloroethane onSalmonella typhimurium. I. Activation through conjugation with glutathione in vitro. Chem. Biol. Interact. 1978; 20: 1
   PubMed Web of Science ®Google Scholar
• Van Bladeren P. J., Breimer D. D., Rotteveel-Smijs G. M. T., De Jong R. A. W., Buijs W., Van Der Gen A., Mohn G. R. The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane. Biochem. Pharmacol. 1980; 29: 2975
   PubMed Web of Science ®Google Scholar
• Ozawa N., Guengerich F. P. Evidence for formation of an 5-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA. Proc. Natl. Acad. Sci. U.S.A. 1983; 80: 5266
   PubMed Web of Science ®Google Scholar
• Lock E. A. Renal necrosis produced by halogenated chemicals. Nephrotoxicity: Assessment and Pathogenesis, P. H. Bach, F. W. Bonner, J. W. Bridges, E. A. Lock. John Wiley & Sons, Chichester 1982; 396
   Google Scholar
• Elfarra A. A., Anders M. W. Renal processing of glutathione conjugates: role in nephrotoxicity. Biochem. Pharmacol. 1984; 33: 3729
   PubMed Web of Science ®Google Scholar
• Lash L. H., Anders M. W. Bioactivation and cytotoxicity of nephrotoxic amino acid and glutathione conjugates. Comments Toxicol. 1986; 1: 87
   Google Scholar
• Anders M. W., Elfarra A. A., Lash L. H. Cellular effects of reactive intermediates: nephrotoxicity ofS-conjugates of amino acids. Arch. Toxicol. 1987; 60: 103
   PubMed Web of Science ®Google Scholar
• Lock E. A. The nephrotoxicity of haloalkane and haloalkene glutathione conjugates. Selectivity and Molecular Mechanisms of Toxicity, F. De Matteis, E. A. Lock. Macmillan Press, Basingstoke HampshireEngland 1987; 59
   Google Scholar
• Gradiski D., Duprat P., Magadur J.-L., Fayein E. Etude toxicologique experimentale de l'hexachlorobutadiene. Eur. J. Toxicol. 1975; 8: 180
   Google Scholar
• Kociba R. J., Schwetz B. A., Keyes D. G., Jersey G. C., Ballard J. J., Dittenber D. A., Quast J. F., Wade C. E., Humiston C. G. Chronic toxicity and reproduction studies of hexachlorobutadiene in rats. Environ. Health Perspect. 1977; 21: 49
   PubMed Web of Science ®Google Scholar
• Harleman J. H., Seinen W. Short-term toxicity and reproduction studies in rats with hexachloro-1,3-butadiene. Toxicol. Appl. Pharmacol. 1979; 47: 1
   PubMed Web of Science ®Google Scholar
• Lock E. A., Ishmael J. The acute toxic effects of hexachloro-1,3-butadiene on the rat kidney. Arch. Toxicol. 1979; 43: 47
   PubMed Web of Science ®Google Scholar
• Berndt W. O., Mehendale H. M. Effects of hexachlorobutadiene (HCBD) on renal function and renal organic ion transport in the rat. Toxicology 1979; 14: 55
   PubMed Web of Science ®Google Scholar
• Walther A., Fischer H. D., Jaeger J., Kenuner C., Kunze D. Biochemical and morphological studies on the toxicity of chlorotrifluoroethylene. Acta Biol. Med. Ger. 1969; 23: 685
   Google Scholar
• Dilley J. V., Carter V. L., Harris E. S. Fluoride ion excretion by male rats after inhalation of one of several fluoroethylenes or hexafluoropropene. Toxicol. Appl. Pharmacol. 1974; 27: 582
   PubMed Web of Science ®Google Scholar
• Potter C. L., Gandolfi A. J., Nagle R., Clayton J. W. Effects of inhaled chlorotrifluoroethylene and hexafluoropropene on the rat kidney. Toxicol. Appl. Pharmacol. 1981; 59: 431
   PubMed Web of Science ®Google Scholar
• Buckley L. A., Clayton J. W., Nagle R. B., Gandolfi A. J. Chlorotrifluoroethylene nephrotoxicity in rats: a subacute study. Fundam. Appl. Toxicol. 1982; 2: 181
   Google Scholar
• Sakharova L. N., Tolgskaya M. S. Toxicity and nature of the effect of some halo derivatives of ethylene-difluoro-dichloroethylene, trifluorochloroethylene and tetrafluoroethylene. Gig. Tr. Prof. Zabol. 1977; 5: 36
   Google Scholar
• Commandeur J. N. M., Oostendorp R. A. J., Schoofs P. R., Xu B., Vermeulen N. P. E. Nephrotoxicity and hepatotoxicity of 1,1,-dichloro-2,2-difluoroethylene in the rat: indications for differential mechanisms of bioactivation. Biochem. Pharmacol. 1987; 36: 4229
   PubMed Web of Science ®Google Scholar
• Kluwe W. M. The nephrotoxicity of low molecular weight halogenated alkane solvents, pesticides and chemical intermediates. Toxicology of the Kidney, J. B. Hook. Raven Press, New York 1981; 179
   Google Scholar
• Ishmael J., Pratt I. S., Lock E. A. Necrosis of the pars recta (S3 segment) of the rat kidney produced by hexachloro-1:3-butadiene. J. Pathol. 1982; 138: 99
   PubMed Web of Science ®Google Scholar
• Nash J. A., King L. J., Lock E. A., Green T. The metabolism and disposition of hexachloro-1,3-butadiene in the rat and its relevance to nephrotoxicity. Toxicol. Appl. Pharmacol. 1984; 73: 124
   PubMed Web of Science ®Google Scholar
• Chasseaud L. F. The role of glutathione and glutathioneS-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv. Cancer Res. 1979; 29: 175
   PubMedGoogle Scholar
• Dohn A. R., Anders M. W. The enzymatic reaction of chlorotrifluoroethylene with glutathione. Biochem. Biophys. Res. Commun. 1982; 109: 1339
   PubMed Web of Science ®Google Scholar
• Dohn A. R., Quebbemann A. J., Borch R. F., Anders M. W. Enzymatic reaction of chlorotrifluoroethene with glutathione:19F NMR evidence for stereochemical control of the reaction. Biochemistry 1985; 24: 5137
   PubMed Web of Science ®Google Scholar
• Morganstern R., Guthenberg C., De Pierre J. W. Microsomal glutathioneS-transferase. Eur. J. Biochem. 1982; 128: 243
   Google Scholar
• Jones T. W., Gerdes R. G., Ormstad K., Orrenius S. The formation of both a mono- and bis- substituted glutathione conjugate of hexachlorobutadiene by isolated hepatocytes and followingin vivo administration to the rat. Chem. Biol. Interact. 1985; 56: 251
   PubMed Web of Science ®Google Scholar
• Earl L. K., McLean A. E. M., Lock E. A. Use of isolated kidney cells for studying nephrotoxicity: hexachloro-1,3-butadiene as a model compound. Hum. Toxicol. 1984; 3: 332
   Google Scholar
• Jones T. W., Wallin A., Thor H., Gerdes R. G., Ormstad K., Orrenius S. The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells. Arch. Biochem. Biophys. 1986; 251: 504
   PubMed Web of Science ®Google Scholar
• Minato S. Isolation of anthglutin, an inhibitor of γ-glutamyl transpeptidase from Penicillium oxalicum. Arch. Biochem. Biophys. 1979; 192: 235
   Web of Science ®Google Scholar
• Dohn D. R., Leininger J. R., Lash L. H., Quebbemann A. J., Anders M. W. Nephrotoxicity ofS-(2-chloro-1,1,2-trifluoroethyl)glutathione andS-(2-chloro-1,1,2-trifluoroethyl)-l-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene. J. Pharmacol. Exp. Ther. 1985; 235: 851
   PubMed Web of Science ®Google Scholar
• Hassall C. D., Gandolfi A. J., Duhamel R. C., Brendel K. The formation and biotransformation of cysteine conjugates of halogenated ethylenes by rabbit renal tubules. Chem. Biol. Interact. 1984; 49: 283
   PubMedGoogle Scholar
• Lash L. H., Anders M. W. Cytotoxicity ofS-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-l-cysteine in isolated rat kidney cells. J. Biol. Chem. 1986; 261: 13076
   PubMed Web of Science ®Google Scholar
• Okajima K., Inoue M., Morino Y. Topology and some properties of the renal brush border membrane-bound peptidases participating in the metabolism ofS-carbamidomethyl glutathione. Biochem. Biophys. Acta 1981; 675: 379
   PubMed Web of Science ®Google Scholar
• Jones D. P., Moldeus P., Stead A. H., Ormstad K., Jornvall H., Orrenius S. Metabolism of glutathione and glutathione conjugate by isolated kidney cells. J. Biol. Chem. 1979; 254: 2787
   PubMed Web of Science ®Google Scholar
• Stevens J., Hayden P., Taylor G. The role of glutathione metabolism and cysteine conjugate β-lyase in the mechanism ofS-cysteine conjugate toxicity in LLC-PK1 cells. J. Biol. Chem. 1986; 261: 3325
   PubMed Web of Science ®Google Scholar
• Lash L. H., Jones D. P. Uptake of the glutathione conjugateS-(1,2-dichlorovinyl)glutathione by renal basal-lateral membrane vesicles and isolated kidney cells. Mol. Pharmacol. 1985; 28: 278
   PubMed Web of Science ®Google Scholar
• Lock E. A., Ishmael J. Hepatic and renal non-protein sulphydryl concentration following toxic doses of hexachloro-1,3-butadiene in the rat: the effect of Aroclor 1254, phenobarbitone or SKF 525A treatment. Toxicol. Appl. Pharmacol. 1981; 57: 79
   PubMed Web of Science ®Google Scholar
• Kluwe W. M., McNish R., Smithson K., Hook J. B. Depletion by 1,2-dibromoethane, 1,2-dibromo-3-chloropropane,tris(2,3-dibromopropyl)-phosphate and hexachloro-1,3-butadiene of reduced non-protein sulphydryl groups in target and nontarget organs. Biochem. Pharmacol. 1981; 30: 2265
   PubMed Web of Science ®Google Scholar
• Hook J. B., Ishmael J., Lock E. A. Nephrotoxicity of hexachloro-1,3-butadiene in the rat: the effect of age, sex and strain. Toxicol. Appl. Pharmacol. 1983; 67: 121
   Google Scholar
• Lock E. A., Ishmael J., Hook J. B. Nephrotoxicity of hexachloro-1,3-butadiene in the mouse: the effect of age, sex, strain, monooxygenase modifiers, and the role of glutathione. Toxicol. Appl. Pharmacol. 1984; 72: 484
   PubMed Web of Science ®Google Scholar
• Ishmael J., Lock E. A. Nephrotoxicity of hexachlorobutadiene and its glutathione-derived conjugates. Toxicol. Pathol. 1986; 14: 258
   PubMedGoogle Scholar
• Odum J., Green T. Perchloroethylene metabolism by the glutathione conjugation pathway. Toxicologist 1987; 7: 269
   Google Scholar
• Dekant W., Metzler M., Henschler D. Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity. J. Biochem. Toxicol. 1986; 1: 57
   PubMedGoogle Scholar
• Dekant W., Metzler M., Henschler D. Identification ofS-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats. Biochem. Pharmacol. 1986; 35: 2455
   PubMed Web of Science ®Google Scholar
• Anders M. W., Lash L. H., Elfarra A. A. Nephrotoxic ammo acid and glutathioneS-conjugates: formation and renal activation. Adv. Exp. Med. Biol. 1986; 197: 443
   PubMedGoogle Scholar
• Anderson P. M., Schultze M. O. Cleavage ofS-(1,2-dichlorovinyl)-l-cysteine by an enzyme of bovine origin. Arch. Biochem. Biophys. 1965; 111: 593
   PubMed Web of Science ®Google Scholar
• Bhattacharya R. K., Schultze M. O. Enzymes in bovine and turkey kidneys which cleaveS-(1,2-dichlorovinyl)-l-cysteine. Comp. Biochem. Physiol. 1967; 22: 723
   PubMed Web of Science ®Google Scholar
• Bhattacharya R. K., Schultze M. O. Properties of DNA treated withS-(1,2-dichlorovinyl)-l-cysteine and a lyase. Arch. Biochem. Biophys. 1972; 153: 105
   PubMed Web of Science ®Google Scholar
• Stonard M. D., Parker V. H. Metabolism ofS-(1,2-dichlorovinyl)-l-cysteine by rat liver mitochondria. Biochem. Pharmacol. 1971; 20: 2429
   PubMed Web of Science ®Google Scholar
• Lock E. A., Green T. Selective activation of chemicals by the kidney: its relevance to toxicity and mutagenicity. Proc. 9th Int. Cong. Pharmacology, W. Paton, J. Mitchell, P. Turner. Macmillan, London 1984; Vol. 1: 197
   Google Scholar
• Green T., Odum J. Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes. Chem. Biol. Interact. 1985; 54: 15
   PubMed Web of Science ®Google Scholar
• Tateishi M., Suzuki S., Shimizu H. Cysteine conjugate β-lyase in rat liver. J. Biol. Chem. 1978; 253: 8854
   PubMed Web of Science ®Google Scholar
• Stevens J. L., Jakoby W. B. Cysteine conjugte β-lyase. Mol. Pharmacol. 1983; 23: 761
   PubMed Web of Science ®Google Scholar
• Stevens J. L. Isolation and characterisation of a rat liver enzyme with both cysteine conjugate β-lyase and kynureninase activity. J. Biol. Chem. 1985; 260: 7945
   PubMed Web of Science ®Google Scholar
• Tomisawa H., Ichihara S., Fukazawa H., Ichimoto N., Tateishi M., Yamamoto L. Purification and characterisation of human hepatic cysteine-conjugate β-lyase. Biochem. J. 1986; 235: 569
   PubMed Web of Science ®Google Scholar
• Dohn A. R., Anders M. W. Assay of cysteine conjugate β-lyase activity withS-(2-benzothiazolyl)cysteine as the substrate. Anal. Biochem. 1982; 120: 379
   PubMed Web of Science ®Google Scholar
• Stevens J. L. Cysteine conjugate β-lyase activities in rat kidney cortex: subcellular localisation and relationship to the hepatic enzyme. Biochem. Biophys. Res. Commun. 1985; 129: 499
   PubMed Web of Science ®Google Scholar
• Stevens J. L., Robbins J. D., Byrd R. A. A purified cysteine conjugate β-lyase from rat kidney cytosol. J. Biol. Chem. 1986; 261: 15529
   PubMed Web of Science ®Google Scholar
• Lash L. H., Elfarra A. A., Anders M. W. Renal cysteine conjugate β-lyase. J. Biol. Chem. 1986; 261: 5930
   PubMed Web of Science ®Google Scholar
• Blagbrough I. S., Bycroft B. W., Evans D. C., Green T., Shaw P. N. Cysteine conjugate substrates for rat renal β-lyase: an examination of the structure-activity relationships. J. Pharm. Pharmacol. 1986, Suppl. 38: 107P
   Google Scholar
• Blagbrough I. S., Bycroft B. W., Evans D. C., Shaw P. N. Rat renal C-S lyase: mixed inhibition kinetics shown by substituted phenyl-l-cysteine conjugates. J. Pharm. Pharmacol. 1987; 39: 109P
   Google Scholar
• Wallach D. P. Studies on the GABA pathway. I. The inhibition of γ-amino-butyric acid-α-ketoglutaric acid transaminasein vitro andin vivo by u-7524 (amino-oxyacetic acid). Biochem. Pharmacol. 1961; 5: 323
   PubMed Web of Science ®Google Scholar
• Elfarra A. A., Jakobson I., Anders M. W. Mechanism ofS-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. Biochem. Pharmacol. 1986; 35: 283
   PubMed Web of Science ®Google Scholar
• Robbins J. D., Stevens J. L. Purification and characterisation of a cysteine conjugate β-lyase activity from rat kidney mitochondria, and its dependence on an αketo acid for activity. Pharmacologist 1986; 28: 196
   Google Scholar
• Hassall C. D., Gandolfi A. J., Brendel K. Effect of halogenated vinyl cysteine conjugates on renal tubular active transport. Toxicology 1983; 26: 285
   PubMed Web of Science ®Google Scholar
• Hassall C. D., Brendel K., Gandolfi A. J. Regulation of aS(trans-1,2-dichlorovinyl)-l-cysteine-induced renal tubular toxicity by glutathione. J. Appl. Toxicol. 1983; 3: 321
   PubMedGoogle Scholar
• Jaffe D. R., Hassall C. D., Brendel K., Gandolfi A. J. In vivo andin vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene. J. Toxicol. Environ. Health 1983; 11: 857
   PubMed Web of Science ®Google Scholar
• Schnellmann R. G., Lock E. A., Mandel L. J. A mechanism ofS-(1,1,2,3,4-pentachloro-1,3-butadienyl)-l-cysteine (PCBC) toxicity to rabbit proximal tubules. Toxicol. Appl. Pharmacol. 1987; 90: 513
   PubMed Web of Science ®Google Scholar
• Earl L. K. Some Experimental Studies on Mechanisms of Nephrotoxicity. University of London, England 1985, Ph.D. thesis
   Google Scholar
• Elfarra A. A., Lash L. H., Anders M. W. Metabolic activation and detoxification of nephrotoxic cysteine and homocysteine conjugates. Proc. Natl. Acad. Sci. U.S.A. 1986; 83: 2667
   PubMed Web of Science ®Google Scholar
• Lock E. A., Odum J., Ormond P. Transport ofN-acetyl-S-pentachloro-1,3-butadienylcysteine by rat renal cortex. Arch. Toxicol. 1986; 59: 12
   PubMed Web of Science ®Google Scholar
• Pratt I. S., Lock E. A. Deacetylation and further metabolism of the mercapturic acid of hexachloro-1,3-butadiene by rat kidney cytosol, in vitro. Arch. Toxicol.
   Google Scholar
• Lash L. H., Dekant W., Anders M. W. Bioactivation ofS-(2-chloro-1,1,2-trifluoroethyl)-l-cysteine. Abstr., 3rd Int. Symp. Nephrotoxicity, Guildford, SurreyUK, August, 3 to 71987
   Google Scholar
• Derr R. F., Schultze M. D. The metabolism of35S-(1,2-dichlorovinyl)-l-cysteine in the rat. Biochem. Pharmacol. 1963; 12: 465
   PubMed Web of Science ®Google Scholar
• Hassall C. D., Gandolfi A. J., Brendel K. Correlation of thein vivo andin vitro renal toxicity ofS-(1,2-dichlorovinyl)-l-cysteine. Drug Chem. Toxicol. 1983; 6: 507
   PubMed Web of Science ®Google Scholar
• Silber P. M., Gandolfi A. J., Brendel K. Early biological indicators ofS-(1,2-dichlorovinyl)-l-cysteine nephrotoxicity in the rabbit. Drug Chem. Toxicol. 1986; 9: 285
   PubMed Web of Science ®Google Scholar
• Lock E. A., Ishmael J. Effect of the organic acid transport inhibitor probenecid on renal cortical uptake and proximal tubular toxicity of hexachloro-1,3-butadiene and its conjugates. Toxicol. Appl. Pharmacol. 1985; 81: 32
   PubMed Web of Science ®Google Scholar
• Reichert D., Schutz S., Metzler M. Excretion pattern and metabolism of hexachlorobutadiene in rats: evidence for metabolic activation by conjugation reactions. Biochem. Pharmacol. 1985; 34: 399
   Google Scholar
• Reichert O., Schutz S. Mercapturic acid formation is an activation and intermediary step in the metabolism of hexachlorobutadiene. Biochem. Pharmacol. 1986; 35: 1271
   PubMed Web of Science ®Google Scholar
• Henschler D., Bonse G. Metabolic activation of chlorinated ethylenes: dependance of mutagenic effect on electrophilic reactivity of the metabolically formed epoxides. Arch. Toxicol. 1977; 39: 7
   PubMed Web of Science ®Google Scholar
• Jewell S. A., Bellomo G., Thor H., Orrenius S., Smith M. T. Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. Science 1982; 217: 1257
   PubMed Web of Science ®Google Scholar
• Trump B. F., Berezeski I. K. Role of sodium and calcium regulation in toxic cell injury. Drug Metabolism and Drug Toxicity, J. R. Mitchell, M. G. Homing. Raven Press, New York 1984; 261
   Google Scholar
• Stonard M. D. Further studies on the site and mechanism of action ofS-(1,2-dichlorovinyl)-l-cysteine andS-(1,2-dichlorovinyl)-3-mercaptopropionic acid in rat liver. Biochem. Pharmacol. 1973; 22: 1329
   PubMed Web of Science ®Google Scholar
• Stonard M. D., Parker V. H. 2-Oxoacid dehydrogenases of rat liver mitochondria as the site of action ofS-(1,2-dichlorovinyl)-l-cysteine andS-(1,2-dichlorovinyl)-3-mercaptopropionic acid. Biochem. Pharmacol. 1971; 20: 2417
   PubMed Web of Science ®Google Scholar
• De Meester C., Mercier M., Poncelet F. Mutagenic activity of butadiene, hexachlorobutadiene and isoprene. Industrial and Environmental Xenobiotics, I. Gut, M. Cikrt, G. L. Plaa. Springer-Verlag, New York 1981; 195
   Google Scholar
• Stott W. T., Quasi J. F., Watanabe P. G. Differentiation of the mechanisms of oncogenicity of 1,4-dioxane and 1,3-hexachlorobutadiene in the rat. Toxicol. Appl. Pharmacol. 1981; 60: 287
   PubMed Web of Science ®Google Scholar
• Reichert D., Neudlecker T., Schutz S. Mutagenicity of hexachlorobutadiene, perchlorobutenoic acid and perchlorobutenoic acid chloride. Mutat. Res. 1984; 137: 89
   PubMed Web of Science ®Google Scholar
• Wild D., Schutz S., Reichert D. Mutagenicity of the mercapturic acid and otherS-containing derivatives of hexachloro-1,3-butadiene. Carcinogenesis 1986; 7: 431
   PubMed Web of Science ®Google Scholar
• Kociba R. J., Keyes D. G., Jersey G. C., Ballard J. J., Dittenber D. A., Quasi J. F., Wade C. E., Humiston C. G., Schwetz B. A. Results of a two year chronic toxicity study with hexachlorobutadiene in rats. Am. Ind. Hyg. Assoc. J. 1977; 38: 589
   PubMedGoogle Scholar
• Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene). F344/N Rats and B₆C₃F₁ Mice (Inhalation Studies). National Toxicology Program, Research Triangle Park, NC 1986, NTP Tech. Rep. No. 311
   Google Scholar
• Kluwe W. M., Abdo K. M., Huff J. Chronic kidney disease and organic chemical exposures: evaluations of casual relationships in humans and experimental animals. Fundam. Appl. Toxicol. 1984; 4: 889
   PubMedGoogle Scholar
• Goldsworthy T. L., Lyght O., Popp J. A. Relationship between alpha-2u-globulin, protein droplet accumulation and cell replication in male and female rats exposed to chlorinated hydrocarbons. Proc. Am. Assoc. Cancer Res. 1987; 28: 87
   Google Scholar
• Short B. G., Burnett V. L., Swenberg J. A. Histopathology and cell proliferation induced by 2,2,4-trimethylpentane in male rat kidney. Toxicol. Pathol. 1986; 14: 194
   PubMedGoogle Scholar
• Short B. G., Burnett V. L., Cox M. G., Bus J. S., Swenberg J. A. Site-specific renal cytotoxicity and cell proliferation in male rats exposed to petroleum hydrocarbons. Lab. Invest. 1987; 51: 564
   Google Scholar
• Green T., Odum J., Foster J. R., Hext P. M. Perchloroethylene induced hepatic peroxisome proliferation in mice and renal hyaline droplet formation in rats. Toxicologist 1986; 6: 314
   Google Scholar
• Toxicology and Carcinogenesis Studies of Trichloroethylene. F344/N Rats and B₆C₃F₁ Mice (Gavage). National Toxicology Program, Research Triangle Park, NC 1982, NIH Publ. No. 83–1799
   Google Scholar
• Toxicology and Carcinogenesis Studies of Trichloroethylene. Four Strains of Rats (Gavage), (draft report). National Toxicology Program, Research Triangle Park, NC 1986
   Google Scholar
• Maltoni C., Lefemine G., Colti G. Experimental research on trichloroethylene carcinogenesis. Archives of Research on Industrial Carcinogenesis, C. Maltoni, M. A. Mehlman. Princeton Scientific Publishing, Princeton 1987; Vol. 5
   Google Scholar
• Green T., Prout M. S. Species differences in response to trichloroethylene. II. Biotransformation in rats and mice. Toxicol. Appl. Pharmacol. 1985; 79: 401
   PubMed Web of Science ®Google Scholar
• Jaffe D. R., Gandolfi A. J., Nagle R. B. Chronic toxicity ofS-(trans-1,2-dichlorovinyl)-l-cysteine in mice. J. Appl. Toxicol. 1984; 4: 315
   PubMed Web of Science ®Google Scholar
• Davis M. E., Berndt W. O., Mehendale H. M. Disposition and nephrotoxicity of hexachloro-1,3-butadiene. Toxicology 1980; 16: 179
   PubMed Web of Science ®Google Scholar
• Stonard M. D., Gore C. W., Oliver G. J. A., Smith I. K. Urinary enzymes and protein patterns as indicators of injury to different regions of the kidney. Fundam. Appl. Toxicol. 1987; 9: 339
   PubMedGoogle Scholar
• Schaeffer V. H., Stevens J. L. The transport ofS-cysteine conjugates in LLC-PK1 cells and its role in toxicity. Mol. PharmacoL 1987; 31: 506
   PubMed Web of Science ®Google Scholar
• Goldsworthy T. L., Lyght O., Burnett V., Popp J. A. Potential role of alpha-2u-globulin, protein droplet accumulation and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene and pentachloroethane. Toxicol. Appl. Pharmacol 1988, submitted
   Google Scholar