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Research Article

Factors that Influence Formation of Sister Chromatid Exchanges in Human Blood Lymphocytes

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Pages 43-86 | Published online: 26 Sep 2008

References

  • Taylor J. H., Woods P. S., Hughes W. L. The organization and duplication of chromosomes as revealed by autoradiographic studies using tritium-labelled thymidine. Proc. Natl. Acad. Sci. U.S.A. 1957; 43: 122
  • Taylor J. H. Sister chromatid exchanges in tritium-labelled chromosomes. Genetics 1958; 43: 515
  • Latt S. A. Microfluorometric analysis of DNA synthesis in human metaphase chromosomes. Proc. Natl. Acad. Sci. U.S.A. 1973; 70: 3395
  • Latt S. A. Localization of sister chromatid exchanges in human chromosomes. Science 1974; 185: 74
  • Perry P., Wolff S. New Giemsa method for differential staining of sister chromatids. Nature (London) 1974; 261: 156
  • Evans H. J. Molecular mechanisms in the induction of chromosomal aberrations. Progress in Genetic Toxicology, D. Scott, B. A. Bridges, F. H. Sobels. Elsevier, Amsterdam 1977; 57
  • Shafer D. A. Replication bypass SCE mechanisms and the induction of SCE by single-strand adducts or lesions of DNA. Basic Life Sci. 1984; 29(Part A)245
  • Wang J., Lin L. F. DNA topoisomerases: enzymes that catalyze the concerted breaking and rejoining of DNA backbone bands. Molecular Genetics, J. H. Taylor. Academic Press, New York 1979; Vol. 3: 65
  • Liu L. F., Liu C. C., Alberts B. M. Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell 1980; 19: 697
  • McClintock B. The production of homozygous deficient tissues with mutant characteristics by means of the aberrant mitotic behaviour of ring shaped chromosomes. Genetics 1938; 23: 315
  • Mutchinick O., Ruz L., Casas L. Time of first generation metaphases. I. The effect of various culture media and fetal calf serum in human lymphocyte cultures. Mutat. Res. 1980; 70: 337
  • Sharma T., Das B. C. Culture media and species related variations in the requirements of 5-bromodeoxyuridine for differential sister chromatid staining. Mutat. Res. 1981; 81: 357
  • Lamberti L., Bigatti P. P., Ardito G. Cell kinetics and sister-chromatid-exchange frequency in human lymphocytes. Mutat. Res. 1983; 120: 193
  • Matsubara S., Suzuki S., Kuwabara Y. The effects of diagnostic X-ray and contrast media on lymphocyte chromosomes. ROFO 1984; 140: 215
  • Sinha A. K., Linscombe V. A., Gollapudi B. B., Flake R. E. Evaluation of culture media on cell cycle kinetics and incidence of chromosomal aberrations in human blood cells. Can. J. Genet. Cytol. 1984; 26: 7
  • Bianchi N. O., Bianchi M. S., Lerramendy M. Kinetics of human lymphocyte division and chromosomal radiosensitivity. Mutat. Res. 1979; 63: 317
  • Morgan W. F., Crossen P. E. Factors influencing sister chromatid exchange rate in cultured human lymphocytes. Mutat. Res. 1981; 81: 395
  • Snope A.-J., Rary J. M. Cell-cycle duration and sister chromatid exchange frequency in cultured human lymphocytes. Mutat. Res. 1979; 63: 345
  • Saniesson B., Lindahl-Kiessling K., Mattsson A. SCE in B and T lymphocytes, possible implications for Bloom's syndrome. Clin. Genet. 1979; 16: 133
  • Carrano A. V., Minkler J. L., Stetka D. G., Moore D. H., II. Variation in the sister chromatid exchange frequency in human lymphocytes. Environ. Mutagen. 1980; 2: 325
  • Lindblad A., Lambert B. Relation between sister chromatid exchanges, cell proliferation and proportion of B and T cells in human lymphocyte cultures. Hum. Genet. 1981; 57: 31
  • Dolfini S. F., Cadirola S. Relationship between sister chromatid exchanges and DNA replication in somatic cells of Drosophila melanogaster. Chromosoma 1981; 83: 81
  • Bochkov N. P., Chebotarev A. N., Filippova T. V., Plantonova V. I., Stukalov S. V., Debova G. A. Alterations in the baseline sister chromatid exchange frequency in human lymphocyte culture following a number of cell divisions. Mutat. Res. 1984; 127: 149
  • Bochkov N. P., Chebotarev A. N., Plantanova V. I., Debova G. A. Decrease in the spontaneous frequency level of sister chromatid exchanges in cell division in culture. Tsitol. Genet. 1984; 18: 54
  • Becher R., Sandberg A. A. Sister chromatid exchange level and cell cycle time in human bone marrow cells and lymphocytes. Cancer Genet. Cytogenet. 1984; 11: 19
  • Das B. C., Sharma T. Effects of temperature on the frequency of sister chromatid exchanges (SCEs) in peripheral blood lymphocytes of man and muntjac. Environ. Mutagen. 1984; 6: 25
  • Parkes D. T., Scott D., Stewart A. Changes in spontaneous SCE frequencies as a function of sampling time in lymphocytes from normal donors and cancer patients. Mutat. Res. 1985; 147: 113
  • Littlefield L. G., Colyer S. P., DuFrain R. J. SCE evaluations in human lymphocytes after Go exposure to mitomycin C. Lack of expression of MMC-induced SCEs in cells that have undergone greater than two in vitro divisions. Mutat. Res. 1983; 107: 119
  • Ishii Y., Watanani M. Cell-stage dependence of the formation of SCEs and chromosomal aberrations. Basic Life Sci. 1984; 29(Part A)173
  • Kaerki N. T., Ilonen J., Reunanen M. Increased sister chromatid exchange rate and its regression during prolonged incubation in lymphocyte cultures from patients with multiple sclerosis. Mutat. Res. 1986; 160: 215
  • Morimolo K., Sato-Mizuno M., Koizumi A. Sister-chromatid exchanges and cell cycle kinetics in human lymphocyte cultures exposed to alkylating mutagens: apparent deformity in dose-response relationships. Mutat. Res. 1985; 152: 187
  • Iijima K., Morimoto K. Cell-stage dependence of mutagen-induced sister-chromatid exchanges in human lymphocyte cultures. Mutat. Res. 1986; 162: 121
  • Tohda H., Oikawa A. Proliferation-dependent reduction of sister chromatid exchange frequency induced by mitomycin C in human lymphoblastoid cells and its suppression by inhibitors of DNA replication. Mutat. Res. 1986; 163: 167
  • Kato H. Spontaneous and induced sister chromatid exchanges as revealed by the BUdR-labelling method. Int. Rev. Cytol. 1977; 49: 55
  • Kato H., Sandberg A. A. The effect of sera on sister chromatid exchanges in vitro. Exp. Cell Res. 1977; 109: 445
  • Ghosh P. K., Nand R. Reduced frequency of sister chromatid exchanges in human lymphocytes cultured with autologous serum. Hum. Genet. 1979; 51: 167
  • McFee A. F., Sherrill M. N. Mitotic response and sister chromatid exchanges in lymphocytes cultured in sera from different sources. Experientia 1981; 37: 27
  • Das B. C., Sharma T. Reduced frequency of baseline sister chromatid exchanges in lymphocytes grown in antibiotics and serum-excluded culture medium. Hum. Genet. 1983; 64: 249
  • Wiencke J. K., Kelsey K., Kreiger R., Garry V. F. Serum- and plasma-dependent variations of benzo(a)pyrene-induced sister chromatid exchange in human lymphocytes. Basic Life Sci. 1984; 29(Part B)715
  • Sutou S. Spontaneous sister chromatid exchanges in Chinese hamster cells in vivo and in vitro. Mutat. Res. 1981; 82: 331
  • Natarajan A. T., Rottereel A. H. M., Van Pietersson J., Schliermann M. G. Influence of incorporated 5-bromodeoxyuridine on the frequencies of spontaneous and induced sister chromatid exchanges, detected by immunological methods. Mutat. Res. 1986; 163: 51
  • Barnezai R. Microtechnique for leukocyte culture from whole blood without serum supplementation. Indian J. Exp. Biol. 1982; 20: 756
  • Deknudt G., Kamra O. Influence of various mitogens on the yield of sister chromatid exchanges, induced by chemicals, in human lymphocytes. Mutat. Res. 1983; III: 161
  • Deknudt G. Importance of the mitogen in sister chromatid exchange studies. Basic Life Sci. 1984; 29(Part B)695
  • Ito-Kuwa S., Aoki S. Increased sister chromatid exchange in human lymphocyte cultures infected with mycoplasma. Microbiol. Immunol. 1984; 28: 893
  • D'Souza D., Thomas I. M. Spontaneous chromosomal aberrations and sister chromatid exchanges (SCEs) in peripheral blood lymphocytes of untreated leprosy patients. Leprosy Rev.
  • Tucker J. D., Christensen M. L. Effects of anticoagulants upon sister chromatid exchanges, cell cycle kinetics, and mitotic index in human peripheral lymphocytes. Mutat, Res. 1987; 190: 225
  • Heindorff K., Aurich O., Michaelis A., Rieger R. Genetic toxicology of ethylenediaminete-traacetic acid (EDTA). Mutat. Res. 1983; 115: 149
  • Wolff S., Perry P. Differential Giemsa staining of sister chromatids and the study of sister chromatid exchanges without autoradiography. Chromosoma 1974; 48: 341
  • Kato H. Spontaneous sister chromatid exchanges detected by a BUdR-labelling method. Nature (London) 1974; 251: 70
  • Kato H. Induction of sister chromatid exchanges by chemical mutagens and its possible relevance to DNA repair. Exp. Cell Res. 1974; 85: 238
  • Carrano A. V., Wolff S. Distribution of sister chromatid exchanges in the euchromatin and heterochromatin of the Indian muntjac. Chromosoma 1975; 53: 361
  • Stetka D. G., Carrano A. V. The interaction of Hoechst-33258 and BrdU-substituted DNA in the formation of sister chromatid exchanges. Chromosoma 1977; 63: 21
  • Lambert B., Hansson K., Lindsten J., Sten J., Werelius B. Bromodeoxyuridine-induced sister chromatid exchanges in human lymphocytes. Hereditas 1976; 83: 163
  • Latt S. A., Juergens L. A. Determination of sister chromatid exchange frequencies in human chromosomes. Population Cytogenetics: Studies in Humans, E. B. Porter, I. H. Porter. Academic Press, New York 1977; 217
  • Mazrimas J. A., Stetka J. D. Direct evidence for the role of incorporated BUdR in the induction of sister chromatid exchanges. Exp. Cell Res. 1978; 117: 23
  • Davidson R. L., Kaufman E. R., Dougherty C. P., Quellette A. M., DiFolco C. M., Latt S. A. Induction of sister chromatid exchanges by BUdR is largely independent of BUdR content of DNA. Nature (London) 1980; 284: 74
  • Jacob M., Raman R., Sharma T. Cell cycle kinetics of PHA-stimulated muntjac lymphocytes (in vitro). II. Effect of different concentrations of BrdU on cell cycle progression. Mutat. Res. 1980; 70: 127
  • Natarajan A. T., Tales A. D., Meijers M., Neuteboom I., de Vogel N. Induction of sister chromatid exchanges (SCEs) and chromosomal aberrations by mitomycin C and methyl methane sulfonate in Chinese hamster ovary cells. Mutat. Res. 1983; 121: 211
  • Pinkel D., Thompson L. H., Gray J. W., Vanderlaan M. Measurement of sister chromatid exchanges at very low bromodeoxyuridine substitution levels using monoclonal antibody in Chinese hamster ovary cells. Cancer Res. 1985; 45: 5795
  • Hsu T. C., Somers C. E. Effects of 5-bromodeoxyuridine on mammalian chromosomes. Proc. Natl. Acad. Sci. U.S.A. 1961; 396
  • Dewey W. C., Humphrey R. M. Increase in radiosensitivity to ionizing radiation related to replacement of thymidine in mammalian cells with 5-bromodeoxyuridine. Radiat. Res. 1965; 26: 538
  • Huang C. C. Induction of a high incidence of damage to the X-chromosomes ofRattus (Mastomys)natalensis by base analogue, viruses, and carcinogens. Chromosoma 1967; 23: 162, 179
  • Gupta P., Sharma T. Non-random distribution of aberrations and identification with C- and G-bandings of the position of breakage points on muntjac chromosomes induced by mitomycin C, bromodeoxyuridine and hydroxylamine. Mutat. Res. 1981; 81: 63
  • Tice R., Schneider E. L., Rary J. M. The utilization of bromodeoxyuridine incorporation into DNA for the analysis of cellular kinetics. Exp. Cell Res. 1976; 102: 232
  • Vulips N., Purrot R. J., Lloyd D. C. The use of harlequin staining to assess radiation effects on the in vitro cell cycle kinetics of human lymphocytes. Mutat. Res. 1978; 51: 145
  • Scott D., Lyons C. Y. Homogeneous sensitivity of human peripheral blood lymphocytes to radiation-induced chromosome damage. Nature (London) 1979; 278: 756
  • Hendersson E. E., Strauss B. Differences in the incorporation of bromodeoxyuridine by human blastoid cell lines. Cell 1975; 5: 381
  • Das B. C., Sharma T. Blood lymphocyte culture system: quantitative analysis of X-ray-induced chromosome aberrations in man, muntjac and cattle. Mutat. Res. 1983; 110: 111
  • Schwartz D. Studies on crossing over in maize and Drosophila. J. Cell Comp. Physiol. 1955; 45(Suppl. 2)171
  • Brewen J. G., Peacock W. J. The effect of Initiated thymidine on sister chromatid exchange in a ring chromosome. Mutat. Res. 1969; 7: 433
  • Haus E., Lakatua J. D., Swoyer J., Sackett-Lundeen L. Chronobiology in hematology and immunology. Am. J. Anat. 1983; 168: 467
  • D'Souza D., Thomas I. M., Das B. C. Variation in chromosomal damage as a function of biological rhythms in women. Hum. Genet.
  • Bianchi N. O., Larramendy M. L. The effects of incorporated tritium and bromodeoxyuridine on the frequency of sister chromatid exchanges. Chromosoma 1983; 88: 11
  • Painter R. B. A replication model for sister chromatid exchange. Sister Chromatid Exchange, A. A. Sandberg. Alan R. Liss, New York 1982; 115
  • Bender M. A., Brewen J. G. Factors influencing chromosome aberration yields in the human peripheral leukocyte system. Mutat. Res. 1969; 8: 383
  • Steffen J., Michalowski A. Heterogeneous chromosomal sensitivity to phytohaemagglutinin-stimulated human blood lymphocytes in culture. Mutat. Res. 1973; 17: 367
  • Beek B., Obe G. Sister chromatid exchanges in human leukocyte chromosomes: spontaneous and induced frequencies in early- and late-proliferating cells in vitro. Hum. Genet. 1979; 49: 51
  • Lezana E., Bianchi N. O., Bianchi M., Zabala-Suarez J. E. Sister chromatid exchanges in Down syndromes and normal human beings. Mutat. Res. 1977; 45: 85
  • Knuutila S., Mäki-Paakkanen J., Kähkönen M., Hokkanen M. An increased frequency of chromosomal changes and SCEs in cultured blood lymphocytes of 12 subjects vaccinated against smallpox. Hum. Genet. 1978; 41: 89
  • Ishii Y., Bender M. A. Factors influencing the frequency of mytomycin C-induced sister chromatid exchanges in 5-bromodeoxyuridine substituted human lymphocytes in culture. Mutat. Res. 1978; 51: 419
  • Craig-Holmes A. P., Shaw M. W. Effects of six carcinogens on SCE frequency and cell kinetics in cultured human lymphocytes. Mutat. Res. 1977; 46: 375
  • Lambert B., Leonard A., Holmberg K., Francesconi D. Use of sister chromatid exchange to monitor human populations for exposure to toxicologically harmful agents. Sister Chromatid Exchange, S. Wolff. John Wiley & Sons, New York 1982; 149
  • Sharma T., Das B. C. The effect of storage of blood on the yield of X-ray-induced chromosome aberrations and spontaneous sister chromatid exchanges. Int. J. Radiat. Biol. 1984; 45: 151
  • Ivanov B., Leonard A., Dekmidt G. H. Blood storage and the rate of chromosome aberrations after in vitro exposure to ionizing radiations. Radiat. Res. 1973; 55: 469
  • Deknudt G. H., Léonard A., Decat G., Influence of blood storage in glass or plastic bottles on the induction of chromosomal abnormalities by X-irradiation
  • Rao P. N., Engelberg J. HeLa cells: effects of temperature on life cycle. Science 1965; 148: 1092
  • Sisken J. E., Morasca L., Kirby S. Effects of temperature on the kinetics of mitotic cycle of mammalian cells in culture. Exp. Cell Res. 1965; 39: 103
  • Buchmann W., Timofeeff-Ressovsky N. W. Über die Wirkung der Temperatur auf den Mutation-sprozess bei Drosophila melanogaster. II. Behandlung der Männchen mit Temperaturschocks. Z. Indukt. Abstamm. Vererbungs. 1935; 70: 130
  • Bessman M. J., Reha-Krantz L. J. Studies on the biochemical basis of spontaneous mutation. V. Effect of temperature on mutation frequency. J. Mol. Biol. 1979; 116: 115
  • Arnold C. G. Chromosome aberrations in plants. Chemical Mutagenesis in Mammals and Man, F. Vogel, G. Röhnbom. Springer-Verlag, Berlin 1970; 222
  • Sarachek A., Bish J. T. Effects of growth temperature and caffeine on genetic response ofCandida albicans to ethyl methane sulfonate, nitrous acid and ultraviolet radiation. Mycopathologia 1976; 60: 51
  • Sturelid S., Kihlman B. A. The temperature and time factors on caffeine potentiation of chemically induced chromosomal aberrations in root tips of Vicia faba. Hereditas 1978; 88: 27
  • Hampel K. E., Levan A. Breakage in human chromosomes induced by low temperature. Hereditas 1964; 51: 315
  • Speit G. Effects of temperature on sister chromatid exchanges. Hum. Genet. 1980; 55: 333
  • Livingston K., Dethlefsen L. A. Effect of hyperthermia and X-irradiation on sister chromatid exchange (SCE) frequency in Chinese hamster ovary (CHO) cells. Radiat. Res. 1979; 77: 512
  • Pandita T. K. Effect of temperature variation on sister chromatid exchange frequency in cultured human lymphocytes. Hum. Genet. 1983; 63: 189
  • Ishi Y., Bender M. A. Effects of inhibitors of DNA synthesis on spontaneous and ultraviolet light induced sister chromatid exchanges in Chinese hamster cells. Mutat. Res. 1980; 79: 19
  • Kao-Shan C. S., Micetich K., Zwelling L. A., Whang-Peng J. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat. Rep. 1984; 68: 989
  • Martin G., Prescott D. M. Frequency of sister chromatid exchanges following exposure tovarying doses of3H-thymidine or X-rays. J. Cell Biol. 1964; 21: 159
  • Gatti M., Pimpinelli S., Olivieri G. The frequency and distribution of isolabelling in Chinese hamster chromosomes after exposure to X-rays. Mutat. Res. 1974; 23: 229
  • Perry P., Evans H. J. Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange. Nature (London) 1975; 258: 121
  • Painter R. B., Morgan W. F. SCEs induced by ionizing radiation are not the result of exchanges between homologous chromosomes. Mutat. Res. 1983; 121: 205
  • Das B. C., Sharma T. Enhanced frequency of chromosomal aberrations in lymphocytes of male compared with female muntjacs after X-ray irradiation in vitro. Nature (London) 1981; 290: 604
  • Sharma T., Das B. C. Higher incidence of spontaneous sister chromatid exchanges (SCEs) and X-ray-induced chromosome aberrations in peripheral blood lymphocytes during pregnancy. Mutat. Res. 1986; 174: 27
  • Galloway S. M. Ataxia telangiectasia: the effects of chemical mutagens and X-rays on SCE in blood lymphocytes. Mutat. Res. 1977; 45: 343
  • Littlefield L. G., Colyer S. P., Joiner E. E., DuFrain R. J. Sister chromatid exchanges in human lymphocytes exposed to ionizing radiation during GO. Radiat. Res. 1979; 78: 514
  • Little J. B. Biological consequences of X-ray-induced DNA damage and repair processes in relation to cell killing and carcinogenesis. DNA Repair Mechanisms. Academic Press, New York 1978; Vol. 9: 701, ICN-UCLA Symposium on Molecular Biology
  • Fornace A. J., Jr., Nagasawa H., Little J. B. Relationship of DNA repair to chromosome aberrations, sister chromatid exchanges, and survival during liquid-holding recovery in X-irradiated mammalian cells. Mutat. Res. 1980; 70: 323
  • Duncan A. M., Evans H. J. Gamma-irradiation of human peripheral lymphocytes: effects of low and prolonged irradiation on sister chromatid exchange induction. Int. J. Radiat. Biol. 1983; 43: 175
  • Gundy S., Varga L., Bender M. A. Sister chromatid exchange frequency in human lymphocytes exposed to ionizing radiation in vivo and in vitro. Radiat. Res. 1984; 100: 47
  • Tuschl H., Kovac R., Altmann H. UDS and SCE in lymphocytes of persons occupationally exposed to low levels of ionizing radiation. Health Phys. 1983; 45: 1
  • Kale R., Bender M. A. No liquid holding recovery for chromosomal aberrations or sister chromatid exchanges in irradiated G1 human lymphocytes. Mutat. Res. 1983; 122: 53
  • Abramovsky-Kaplan I., Jones I. S. Sister chromatid exchange induced by X-irradiation of retinoblastoma lymphocytes. Invest. Ophthalmol. Vis. Sci. 1984; 25: 698
  • Kato H. Photoreactivation of sister chromatid exchanges induced by ultraviolet irradiation. Nature (London) 1974; 249: 552
  • Kato H. Induction of sister chromatid exchanges by UV light and its inhibition by caffeine. Exp. Cell Res. 1973; 82: 382
  • Rommelaere J., Susskind M., Errera M. Chromosome and chromatid exchanges in Chinese hamster cells. Chromosoma 1973; 41: 243
  • Wolff S., Bodycote J., Painter R. B. Sister chromatid exchanges induced in Chinese hamster cells by UV irradiation at different stages of the cell cycle; the necessity of cells to pass through S. Mutat. Res. 1974; 25: 73
  • Wolff S., Rodin B., Cleaver J. E. Sister chromatid exchanges induced by mutagenic carcinogens in normal and xeroderma pigmentosum cells. Nature (London) 1977; 265: 345
  • Ishizaki K., Nikaido O., Takebe H. Photoreactivation of ultraviolet light-induced sister chromatid exchanges in potorous cells. Photochem. Photobiol. 1980; 31: 277
  • Natarajan A. T., van Zedand A. A., Verdegaal-Immerzeel E., Filon A. R. Studies on the influence of photoreactivation on the frequencies of UV-induced chromosomal aberrations, sister chromatid exchanges and pyrimidine dimers in chicken embryonic fibroblasts. Mutat. Res. 1980; 69: 307
  • Perticone P., Heltgren D., Lambert B. Effects of UV-irradiation on the SCE frequency in human lymphocyte cultures. Mutat. Res. 1986; 175: 83
  • Krishnan D., Painter R. B. Photoreactivation and repair replication in rat Kangaroo cells. Mutat. Res. 1973; 17: 213
  • Todd R., Schroy B. C., Lebed M. R. Post-irradiation effects of photoreactivating light and caffeine on cultured marsupial cells exposed to ultraviolet light. Photochem. Photobiol. 1973; 18: 433
  • Griggs H. G., Bender M. A. Photoreactivation of ultraviolet-induced chromosomal aberrations. Science 1973; 179: 86
  • Montkone R. E., Schneider E. L. Induction of sister chromatid exchanges in human cells by fluorescent light. Mutat. Res. 1979; 59: 215
  • Ikushima T., Wolff S. Sister chromatid exchanges induced by light flashes to 5-bromodeoxyuridine and 5-iododeoxyuridine-substitute Chinese hamster chromosomes. Exp. Cell Res. 1974; 87: 15
  • Kato H. Possible role of DNA synthesis in function of sister chromatid exchanges. Nature (London) 1974; 252: 739
  • Kato H. Mechanisms for sister chromatid exchanges and their relation to the production of chromosome aberrations. Chromosoma 1977; 59: 179
  • Kihlman B. A., Natarajan A. T., Andersson H. C. Use of the 5-bromodeoxyuridine-labelling technique for exploring mechanisms involved in the formation of chromosomal aberrations. Mutat. Res. 1978; 52: 181
  • Hutchinson F. The lesions produced by ultraviolet light in DNA containing 5-bromouracil. Q. Rev. Biophys. 1973; 6: 201
  • Liebeskind D., Bases R., Mendez F., Elequin F., Koenigsberg M. Sister chromatid exchanges in human lymphocytes after exposure to diagnostic ultrasound. Science 1979; 205: 1273
  • Goss S. A. Sister chromatid exchange and ultrasound. J. Ultrasound Med. 1984; 4: 463
  • Stella M., Tevisan L., Montaldi A., Zaccaria G., Rossi G., Bianchi V., Levis A. G. Induction of sister-chromatid exchanges in human lymphocytes exposed in vitro and hi vivo to therapeutic ultrasound. Mutat. Res. 1984; 138: 75
  • Ozawa N., Yajima A., Sob K., Takabayashi T., Sato S., Sato A., Suzuki M. Sister chromatid exchanges in human lymphocytes after exposure to pulse-wave ultrasound. Tohoku J. Exp. Med. 1984; 143: 473
  • Pizzarello D. J., Vivtoo A., Madden B., Wolsky A., Keegan A. F., Becker M. Effect of pulsed low-power ultrasound on growing tissues. I. Developing mammalian and insect tissue. Exp. Cell Biol. 1978; 46: 179
  • Pizzarello D. J., Vivino A., Newall J., Wolsky A. Effect of pulsed low-power ultrasound on growing tissues. II. Malignant tissues. Exp. Cell Biol. 1978; 46: 240
  • Liebeskind D., Bases R., Elequin F., Neubort S., Letter R., Goldberg R., Koenigsberg M. Diagnostic ultrasound: effects on the DNA and growth patterns of animal cells. Radiology 1979; 131: 177
  • Miller M. W., Wolff S., Filly R., Cox C., Carstensen E. L. Absence of an effect of diagnostic ultrasound on sister-chromatid exchange induction in human lymphocytes in vitro. Mutat. Res. 1983; 120: 261
  • Brulfert A., Ciaravino V., Miller M. W., Maulik D., Carstensen E. L. Diagnostic insonation of extra utero human placentas: no effect of lymphocytic sister chromatid exchange. Hum. Genet. 1984; 66: 289
  • Brulfert A., Ciaravino V., Miller M. W. Lack of ultrasound effect on in vitro human lymphocyte sister chromatid exchange. Ultrasound Med. Biol 1984; 10: 309
  • Miller M. W. Does ultrasound induce sister chromatid exchanges. Ultrasound Med. Biol. 1985; 11: 561
  • Ciaravino V., Brulfert A., Miller M. W., Jacobson-Kram D., Morgan W. F. Diagnostic ultrasound and sister chromatid exchanges: failure to reproduce positive findings. Science 1985; 227: 1349
  • Ciaravino V., Miller M. W., Carstensen E. L. Sister-chromatid exchanges in human lymphocytes exposed in vitro to therapeutic ultrasound. Mutat. Res. 1986; 172: 185
  • Cohen M. M., Kunska A., Astemborski J. A., McCulloch D. The effect of low-level 60-Hz electromagnetic fields on human lymphoid cells. II. Sister-chromatid exchanges in peripheral lymphocytes and lymphoblastoid cell lines. Mutat. Res. 1986; 172: 177
  • Lloyd D. C., Saunders R. D., Finnon P., Kowalczuk C. L. No clastogenic effect from in vitro microwave irradiation of GO human lymphocytes. Int. J. Radiat. Biol. 1984; 46: 135
  • Lloyd D. C., Saunders R. D., Moquet J. E., Kowalczuk C. I. Absence of chromosomal damage in human lymphocyte exposed to microwave radiation with hyperthermia. Bioelectromagnetics 1986; 7: 235
  • Dutrillaux B., Fosse A. M., Prieur M., Lejeune J. Chromatid exchanges in human mitotic cells: BudR treatment and bichromatic fluorescence by Acridine Orange. Chromosoma 1974; 48: 327
  • Franceschini P. Semiconservative DNA duplication in human chromosomes treated with BUdR and stained with Acridine Orange. Exp. Cell Res. 1974; 89: 420
  • Latt S. A. Longitudinal and lateral differentiation of metaphase chromosomes based on the detection of DNA synthesis by fluorescence microscopy. Chromosomes Today, P. L. Pearsen, K. R. Lewis. John Wiley & Sons, New York 1976; Vol. 5: 367
  • Latt S. A., Stetten G., Juergens L. A., Willard H. F., Scher C. D. Recent developments in the detection of deoxyribonucleic acid synthesis by 33258 Hoechst fluorescence. J. Histochem. Cytochem. 1975; 23: 493
  • Lin M. S., Comings D. E., Alfi O. S. Optical studies of the interaction of 4′-6-diamindino-2-phenylindole with DNA and metaphase chromosomes. Chromosoma 1977; 60: 15
  • Gratzner H. G., Pilack A., Ingram A. J., Lief R. C. Deoxyribonucleic acid replication in single cells and chromosomes by immunologic techniques. J. Histochem. Cytochem. 1976; 24: 34
  • Zakharov A. F., Egloina N. A. Differential spiralization among mammalian mitotic chromosomes. I. BUdR-revealed differentiation in Chinese hamster chromosomes. Chromosoma 1972; 38: 341
  • Korenberg J. R., Freedlender E. Giemsa technique for the detection of sister chromatid exchanges. Chromosoma 1974; 48: 355
  • Kim M. A. Chromatid Austausch und Heterochromatin Veränderungen menschlicher Chromosomen nach BrdU-Markierung. Humangenetik 1974; 25: 179
  • Goto K., Akematsu T., Shimazu H., Sugiyama T. Simple differential Giemsa staining of sister chromatids after treatment with photosensitive dyes and exposure to light and the mechanism of staining. Chromosoma. 1975; 53: 230
  • Crossen P. E., Pathak S., Arrighi F. E. A high resolution study of the DNA replication patterns of Chinese hamster chromosomes using sister chromatid differential staining technique. Chromosoma 1975; 52: 339
  • Pathak S., Stock A. D., Lusby A. A combination of sister chromatid differential staining and Giemsa banding. Experientia. 1975; 31: 916
  • Scheres J. M. J. C., Hustinx T. W. J., Ruttem F. J., Merkx G. F. M. “Reverse” differential staining of sister chromatids. Exp. Cell Res. 1977; 109: 466
  • Takayama S., Akanishi S. Differential Giemsa staining of sister chromatids after extraction with acids. Chromosoma 1977; 64: 109
  • Burkholder G. D. Reciprocal Giemsa staining of late DNA replicating regions produced by low and high pH sodium phosphate. Exp. Cell Res. 1978; 111: 489
  • Goto K., Macda S., Kano Y., Sugiyama T. Factors involved in differential Giemsa staining of sister chromatids. Chromosoma 1978; 66: 351
  • Sakanishi S., Takayama S. Reverse differential staining of sister chromatid after substitution with BUdR and incubation in sodium phosphate solution. Exp. Cell Res. 1978; 115: 448
  • Kihlman B. A., Kronborg D. Sister chromatid exchanges in Vicia faba. I. Demonstration by a modified fluorescent plus Giemsa (FPG) technique. Chromosoma 1975; 51: 1
  • Lin M. S., Latt S. A., Davidson R. L. Microfluorometric detection of asymmetry in the centromeric region of mouse chromosomes. Exp. Cell Res. 1974; 86: 392
  • Latt S. A., Davidson R. L., Lin M. S., Gerald P. S. Lateral asymmetry in the fluorescence of human Y chromosomes stained with 33258 Hoechst. Exp. Cell Res. 1974; 87: 425
  • Angell R. R., Jacobs P. A. Lateral asymmetry in human constitutive heterochromatin. Chromosoma 1975; 51: 301
  • Galloway S. M., Evans H. J. Asymmetrical C-bands and satellite DNA in man. Exp. Cell Res. 1975; 94: 454
  • Gibas Z., Limon J. Isolabeling of the long arm of the human Y chromosome demonstrated by the FPG technique. Chromosoma 1978; 69: 113
  • Goswami H. K. Cytogenetic effects of methyl isocyanate exposure in Bhopal. Hum. Genet. 1986; 74: 81
  • Sperling K., Wegner R. D., Riehm H., Obe G. Frequency and distribution of sister chromatid exchanges in a case of Fanconis anemia. Humangenetik 1975; 27: 227
  • Becher R., Sandberg A. A. Sister chromatid exchange in the centromere and centromeric area. Hum. Genet. 1983; 63: 358
  • Dewdney R. S., Lowell D. P., Jenkinson P. C., Anderson D. Variation in sister chromatid exchange among 106 members of the general U.K. population. Mutat. Res. 1986; 171: 43
  • Whorton E. B., Jr., Tice R. R., Stetka D. G. Statistical design, analysis and influence issues in studies using sister chromatid exchanges. Basic Life Sci. 1984; 29(Part A)431
  • Wutf H. C., Husum B., Engberg-Pedersen H., Niebuhr E. Guidelines for the statistical evaluation of SCE. Basic Life Sci. 1984; 29(Part A)441
  • Vercauteren P., Meulfepas E., Vlietinck R., Cassiman J. J., Van den Berghe H. Statistical evaluation of sister chromatid exchanges: refined method. Basic Life Sci. 1984, Part A: 457
  • Moore D. H., II, Carrano A. V. A statistical analysis of high SCE frequency cells in human lymphocytes. Basic Life Sci. 1984, Part A: 469
  • Carrano A. V., Moore D. H., II. The rationale and methodology for quantifying sister chromatid exchange in humans. Mutagenicity: New Horizons in Genetic Toxicology, J. A. Heddle. Academic Press, New York 1982; 267
  • Alhadeff B., Cohen M. M. Frequency and distribution of sister chromatid exchanges in human peripheral blood lymphocytes. Isr. J. Med. Sci. 1976; 12: 1440
  • Brogdorf W., Kurvink K., Cervenka J. Sister chromatid exchange in Dyskeratosis congenita lymphocytes. J. Med. Genet. 1977; 14: 256
  • Cheng W. S., Mulvihill J. J., Greene M. H., Pickle L. W., Tsai S., Whang-Peng J. Sister chromatid exchanges and chromosomes in chronic myelogenous leukemia and cancer families. Int. J. Cancer 1979; 23: 8
  • Crosaen P. E., Drete M. E., Arrighi F. E., Johnston D. A. Analysis of the frequency and distribution of sister chromatid exchanges in cultured human lymphocytes. Hum. Genet. 1977; 35: 345
  • Das B. C., Rani R., Mitra A. B., Luthra U. K. Baseline frequency of sister chromatid exchanges (SCEs) in newborn lymphocytes and its relationship to in vivo aging in humans. Mutat. Res. 1985; 144: 85
  • Daoud C., Shaw M. W., Craig-Holmes A. Sister chromatid exchange frequency among normal individuals and breast cancer patients. Mamm. Chrom. Newslett. 1976; 17: 26
  • Galloway S. M., Evans H. J. Sister chromatid exchange in human chromosomes from normal individuals and patients with ataxia telangiectasia. Cytogenet. Cell Genet. 1975; 15: 17
  • Ghosh R., Ghosh P. K. Sister chromatid exchanges in betal and tobacco chewers. Mutat. Res. 1984; 139: 79
  • Goyanes-Villaescusa V. J., Ugarte M., Vazques A. Sister chromatid exchange in babies treated by phototherapy. Lancet 1977; 2: 1084
  • Hansteen I. L. A follow up study of PVC workers two years after exposure. Preliminary results using sister chromatid exchange frequency as an assay of genetic damage. Genetic Damage in Man Caused by Environmental Agents, K. Berg. Academic Press, New York 1979; 279
  • Hatcher N. H., Risemberg H. M., Powers M. M., Hook E. B. Sister chromatid exchange and phototherapy. Mutat. Res. 1979; 60: 401
  • Kadam P. R., Advani S. H., Bhisey A. N. Studies on sister chromatid exchanges in patients with Hodgkin's disease. Cancer Genet. Cytogenet. 1986; 22: 265
  • Kurvink K., Bloomfield C. D., Keenan K. M., Levitt S., Cervenka J. Sister chromatid exchanges in lymphocytes from patients with malignant lymphoma. Hum. Genet. 1978; 44: 137
  • Lambert B., Linblad A., Nordenskjold M., Werelius B. Increased frequency of sister chromatid exchanges in cigarette smokers. Hereditas 1978; 88: 147
  • McDonald M. A., Fitzgerald P. H. Sister chromatid exchanges and cell cycle progression in cultured lymphocytes from patients with chronic lymphatic leukemia. J. Natl. Cancer Inst. 1979; 62: 1169
  • Mitra A. B., Murty V. V. V.S., Luthra U. K. Sister chromatid exchanges in leukocytes of patients with cancer of cervix uteri. Hum. Genet. 1982; 60: 214
  • Murthy P. B. K., Prema K. Sister chromatid exchanges in oral contraceptive users. Mutat. Res. 1979; 68: 149
  • Tice R. R., Chaillet J., Schneider E. L. Evidence derived from sister chromatid exchanges of restricted rejoining of chromatid subunits. Nature (London) 1975; 256: 642
  • Sandberg A. A. Sister chromatid exchange in human states. Sister Chromatid Exchange, A. A. Sandberg. Alan R. Liss, New York 1982; 619
  • Oikawa A., Sasaki S., Horaguchi K., Sugawara R., Sato K., Tazawa J., Tohda H., Yokoyama M., Wakui A. Sensitivities of peripheral lymphocyte to induction of sister chromatid exchanges by genotoxicants. Basic Life Sci. 1984, Part B: 813
  • Hirsch B., McGue M., Cervenka J. Characterization of the distribution of sister chromatid exchange frequencies: implications for research design. Hum. Genet. 1984; 65: 280
  • Wulf H. C., Husum B., Plesner A. M., Neibuhr E. Distribution of SCEs in lymphocytes in persons with normal, slightly increased, and heavily increased SCEs. Mutat. Res. 1984; 125: 263
  • Slozina N. M., Golovachev G. D. Frequency of sister chromatid exchanges in human lymphocytes at different times of the day. Tsitologiya 1986; 28: 127
  • Speit G., Duering R., Mehnert K. Variation in the frequency of sister chromatid exchanges in repeated human lymphocyte cultures. Hum. Genet. 1986; 72: 179
  • Nagaya T., Torhimi H. Spontaneous and induced sister chromatid exchanges in lymphocytes of healthy persons. Environ. Res. 1986; 40: 181
  • Hender K., Iselius L., Mitelman F., Norden A., Pero R. M. A twin study of sister chromatid exchanges in human lymphocytes following carcinogen exposure and DNA repair incubation. Cytogenet. Cell Genet. 1984; 38: 189
  • Boehlke J. U., Singh S., Goedde H. W. Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay. Hum. Genet. 1983; 63: 285
  • Hrushesky W. J. M. The clinical application of chronobiology to oncology. Am. J. Anat. 1983; 168: 519
  • Tucker J. D., Christensen M. L., Strout C. L., McGee K. A., Carrano A. V. Variation in the human lymphocyte sister chromatid exchange frequency as a function of time: results of daily and twice-weekly sampling. Environ. Mol. Mutagen. 1987; 10: 69
  • Soper K. A., Stolley P. D., Galloway S. M., Smith J. G., Nichols W. W., Wolman S. R. Sister chromatid exchange (SCE) report on control subjects in a study of occupationally exposed workers. Mutat. Res. 1984; 129: 77
  • Vercauteren P., Meulepas E., Vüetinck R., Cassiman J. J., van den Berghe H. Non-uniform distribution of sister chromatid exchanges in human lymphocytes. Chromosoma 1986; 93: 197
  • Bloom S. E., Hsu T. C. Differential fluorescence of sister chromatids in chicken embryos exposed to 5-bromodeoxyuridine. Chromosoma 1975; 51: 261
  • Vogel W., Bauknecht T. Differential chromatid staining by in vivo treatment as a mutagenicity test system. Nature (London) 1976; 260: 448
  • Allen J. W., Schuler C. F., Latt S. A. A BrdU tablet methodology forin vivo studies of DNA synthesis. Somat. Cell Genet. 1978; 4: 393
  • Latt S. A., Schreck R. R., Loveday K. S., Schuler C. F. In vitro and in vivo analysis of sister chromatid exchange. Pharmacol. Rev. 1979; 30: 501
  • Kanda N., Kato H. A simple technique for in vivo observation of SCE in mouse ascites tumor and spermatogonial cells. Exp. Cell Res. 1979; 118: 431
  • Allen J. W., Latt S. A. Analysis of sister chromatid exchange formation in vivo in mouse spermatogonia as a new test system for environmental mutagens. Nature (London) 1976; 260: 449
  • Lakhotia S. C. In vivo sister chromatid exchange frequencies in fetal and adult cells of mouse. Indian J. Exp. Biol. 1980; 18: 895
  • Abdel-Fadil M. R., Palmer C. G., Heerema N. Effect of temperature variation on sister chromatid exchanges and cell cycle duration in cultured human lymphocytes. Mutat. Res. 1982; 104: 267
  • Santesson B. Different baseline sister chromatid exchange levels in density fractionated human lymphocytes. Hum. Genet. 1986; 73: 114
  • Miller K. Sister chromatid exchange in highly purified human B and T lymphocytes. Hum. Genet. 1986; 72: 160
  • Crossen P. E., Godwin J. M., Bodger M. P. Sister chromatid exchange in immature haemopoietic cells, T- and B-lymphocytes. Hum. Genet. 1986; 72: 101
  • Gutierrez C., Hernandez P., Lopez-Saez J. F. BrdUrd-independent and BrdUrd-dependent SCEs as components of SCE yields: implications for their cellular significance. Basic Life Sci. 1984, Part A: 83
  • Morgan W. F., Wolff S. Effect of bromodeoxyuridine on induced sister chromatid exchanges. Basic Life Sci. 1984, Part A: 281
  • Okey C. H., Saffhill R., Booth J. A. The effect of cell proliferation, bromodeoxyuridine concentration, and deoxynucleotide triphosphate pools on sister chromatid exchange induction. Basic Life Sci. 1984, Part A: 267
  • Kaufman E. R., Davidson R. L. Bromodeoxyuridine mutagenesis in mammalian cells: mutagenesis is independent of the amount of bromouracil in DNA. Proc. Natl. Acad. Sci. U.S.A. 1978; 75: 4982
  • Heartlein M. W., O'Neill J. P., Preston R. J. SCE induction in proportional to substitution in DNA for thymidine by CldU and BrdU. Mutat. Res. 1983; 107: 103
  • Kaufman E. R. Replication of DNA containing 5-bromouracil can be mutagenic in Syrian hamster cells. Mol. Cell Biol. 1984; 4: 2449
  • Kaufman E. R. Induction of sister chromatid exchanges by the replication of 5-bromouracil-substituted DNA under conditions of nucleotide-pool imbalance. Mutat. Res. 1986; 163: 41
  • Wolff S., Bodycote J., Thomas G. H., Cleaver J. E. Sister chromatid exchange in Xeroderma pigmentosum cells that are defective in DNA excision repair or post-replication repair. Genetics 1975; 81: 349
  • Thompson K. V. A., Holliday R. Chromosome changes during the invitro ageing of MRC-5 human fibroblasts. Exp. Cell Res. 1975; 96: 1
  • Kato H., Stich H. F. Sister chromatid exchanges in ageing and repair-deficient human fibroblasts. Nature (London) 1976; 260: 447
  • Latt S. A. Sister chromatid exchange formation. Annu. Rev. Genet. 1981; 15: 11
  • Popescu N. C., DiPaolo J. A. The relevance of sister chromatid exchange to the induction of neoplastic cell transformation. Sister Chromatid Exchange, A. A. Sandberg. Alan R. Liss, New York 1982; 425
  • Pathak S., Ward O. G., Hsu T. C. Rate of sister chromatid exchanges in mammalian cells differing in diploid numbers. Experientia 1977; 33: 875
  • Beek B., Obe G. Sister chromatid exchanges in human leukocyte chromosomes, spontaneous and induced frequencies in early and late replicating cells in vitro. Hum. Genet. 1979; 49: 51
  • Ris H., Jones R. N. The origin of the wide species variation in nuclear DNA content. Int. Rev. Cytol. 1972; 32: 53
  • Vendrely R. Nucleic Acids, E. Chargaff, J. N. Davidson. Academic Press, New York 1955; Vol. 2: 155
  • Augener W., Cohen G., Reuter A., Brittinger G. T-lymphocytes during aging. Lancet 1974; 1: 1164
  • Clot J., Charmanon E., Brochier J. Age-dependent changes of blood lymphocyte subpopulations. Clin. Exp. Immunol 1978; 32: 346
  • Kanungo M. S. I. Changes in enzymes during aging. II. Changes in immunological system. Biochemistry of Ageing. Academic Press, New York 1980; 79
  • Holliday R., Terrant G. M. Altered enzymes in ageing human fibroblasts. Nature (London) 1972; 238: 26
  • Srivastava B. I. S. Changes in enzymatic activity during cultivation of human cells in vitro. Exp. Cell Res. 1973; 80: 305
  • Young V. R., Sateffee W. P., Penckarz P. B., Winterer J. C., Scrimshaw N. S. Total human body protein synthesis in relation to protein requirements at various ages. Nature (London) 1975; 253: 192
  • Kanungo M. S. Biochemistry of ageing. Biochem. Rev. 1970; 41: 13
  • Bochkov N. P., Pilosov R. A. The effect of α rays on human chromosomes. II. The dependence of chromosome aberration frequency upon sex and age. Genetics (USSR) 1968; 4: 93
  • Sasaki M. S., Tonomura A. Chromosomal radiosensitivity in Down's syndrome. Jpn. J. Hum. Genet. 1969; 14: 81
  • Evans H. J., Adams A. X-ray-induced chromosome aberrations in human lymphocytes irradiated in vitro: the influence of exposure conditions, genotype, and age on aberration yields. Advances in Radiation Research, J. F. Duplan, A. Chapiro. Gordon and Breach, New York 1973; Vol. 1: 335
  • Das B. C., Sharma T. Influence of age on the frequency of sister chromatid exchanges and X-ray-induced chromosome aberrations in muntjac. Mutat. Res. 1983; 109: 53
  • Schneider E. L., Kram D., Nakanishi Y., Monticone R. E., Tice R. R., Gilman B. A., Neider M. L. The effect of ageing on sister chromatid exchange. Mech. Ageing Dev. 1979; 9: 303
  • Lambert B., Lindblad A. Sister chromatid exchange and chromosome aberrations in lymphocytes of laboratory personnel. J. Toxicol. Environ. Health 1980; 6: 1237
  • Hender K., Högstedt B., Köling A. M., Mark-Vendel E., Stormbeck B., Mitelman F. Sister chromatid exchanges and structural chromosome aberrations in relation to age and sex. Hum. Genet. 1982; 62: 305
  • Livingston G. K., Cannon L. A., Bishop D. T., Johnson P., Fineman R. M. Sister chromatid exchange: variation by age, sex, smoking, and breast cancer status. Cancer Genet. Cytogenet. 1983; 9: 289
  • Vormittag M. Effect of donor age on inter- and intrachromosomal distribution of sister chromatid exchanges in cultured human lymphocytes. Gerontology 1983; 29: 370
  • Musilova J., Michalova K., Pacovsky V. Induction of sister chromatid exchanges by mitomycin C in lymphocytes of young and old human donors. Gerontology 1984; 30: 365
  • Wen W. N., Liew T. L. The effect of age and cell proliferation on the frequency of sister chromatid exchange in human lymphocytes cultured in vitro. Mech. Ageing Dev. 1983; 21: 377
  • Funes-Crvioto F., Kolmudin-Hedman B., Lindsten J., Nordenskhlold M., Zapat-Gayon C., Lambert B., Norberg E., Olin R., Swensson A. Chromosome aberrations and sister chromatid exchange in workers in chemical laboratories and a rotoprinting factory and in children of women laboratory working workers. Lancet 1977; 2: 322
  • Schneider E. L., Monticone R. E. Cellular aging and sister chromatid exchange. II. The effect of in vitro passage of human fetal lung fibroblasts on baseline and mutagen-induced sister chromatid exchange frequencies. Exp. Cell Res. 1978; 115: 269
  • Ardito G., Lamberti L., Ansaldo E., Ponzetto P. Sister chromatid exchanges in cigarette smoking. I. Human females and their newborns. Mutat. Res. 1980; 78: 209
  • Nakanishi Y., Dein R. A., Schneider E. L. Ageing and sister chromatid exchange. V. The effect of sister chromatid exchanges in mouse and rat bone-marrow cells. Cytogenet. Cell Genet. 1980; 27: 82
  • Schmidt M. A., Sanger W. G. Sister chromatid exchanges in aged human lymphocytes: a brief note. Mech. Ageing Dev. 1981; 16: 67
  • de Arce M. A. The effect of donor sex and age on the number of sister chromatid exchanges in human lymphocytes growing in vitro. Hum. Genet. 1981; 57: 83
  • Goh K. Sister chromatid exchanges in the aging population. J. Med. 1981; 58: 235
  • Waksvik H., Magnus P., Berg K. Effects of age, sex and genes on sister chromatid exchange. Clin. Genet. 1981; 20: 449
  • Hatcher N. H., Hook E. B. Sister chromatid exchange in newborns. Hum. Genet. 1981; 59: 389
  • Hook E. B. Sister chromatid exchanges in newborns: apparent drop immediately after birth. Does this reflect two different populations of lymphocytes. Mutat. Res. 1986; 163: 99
  • Schneider E. L., Gilman B. Aging and sister chromatid exchanges. II. The effect of donor age on mutagen-induced sister chromatid exchange. Hum. Genet. 1979; 46: 57
  • Szilard L. On the nature of ageing process. Proc. Natl. Acad. Sci. U.S.A. 1959; 45: 30
  • Szilard L. A theory of ageing. Nature (London) 1959; 184: 956
  • Trainer K. J., Wigmor J. J., Chrysostomou A., Dempsey J. L., Sashadri R., Morley A. A. Mutation frequency in human lymphocytes increases with age. Mech. Ageing Dev. 1984; 27: 83
  • Hung C. Y., Perkins E. H., Yang W. K. Age-related refractoriness of PHA-induced lymphocyte transformation. I. Comparable sensitivity of spleen cells from young and old mice to culture conditions. Mech. Ageing Dev. 1975; 4: 29
  • Hori Y., Perkins E. H., Halsall M. K. Decline in phytohaemagglutinin responsiveness of spleen cells from ageing mice. Proc. Soc. Exp. Biol. Med. 1973; 144: 48
  • Mathies M., Lipps L., Smith G. S., Walford R. L. Age-related decline in response to phytohaemagglutinin and poke-weed mitogen by spleen cells from hamsters and long-lived mouse strain. J. Gerontol 1979; 28: 425
  • Gebhart E., Lösung J., Wopfner F. Chromosome studies in lymphocytes of patients under cytostatic therapy. I. Conventional chromosome sutdies in cytostatic interval therapy. Hum. Genet. 1980; 55: 53
  • Husum B., Wulf H. C., Neibuhr E. Increased sister chromatid exchange frequency in lymphocytes in healthy cigarette smokers. Hereditas 1982; 98: 85
  • Margolin B. H., Shelby M. D. Sister chromatid exchanges: a reexamination of the evidence for sex and race differences in humans. Environ. Mutagen. 1985; 7(Suppl. 4)63
  • Wulf H. C., Neibuhr E. Different sister chromatid exchange rates in XX and XY cells of a pair of human chimeric twins. Cytogenet. Cell Genet. 1985; 39: 105
  • Haus E., Halberg F., Kuhl J. F. W., Lakatua D. J. Chronopharmacology in animals. Chronobiologia 1974; 1(Suppl. 1)122
  • Tavadia H. B., Fleming K. A., Hume P., Simpson H. W. Circadian variations in the quantity and quality of lymphocyte traffic in human peripheral venous blood. Chronobiology in Allergy and Immunology, J. D. McGovern, M. H. Smolensky, A. Reinberg. Charles C Thomas, Springfield, IL 1977; 187
  • Littlefield L. G., Lever W. E., Miller F. L., Goh K. O. Chromosome breakage studies in lymphocytes from normal women, pregnant women, and women taking oral contraceptives. Am. J. Obstet. Gynecol. 1975; 121: 976
  • Pinto M. R. Possible effects of hormonal contraceptives on human mitotic chromosomes. Mutat. Res. 1986; 169: 149
  • Kochhar T. S. Inducibility of chromosome aberrations by steroid hormones in cultured Chinese hamster ovary cells. Toxicol. Lett. 1985; 29: 201
  • Lukić B., Barjaktarović N. Sister chromatid exchanges in newborns after normal and progesterone treated pregnancies. Mutat. Res. 1987; 191: 121
  • Hill A., Wolff S. Increased induction of sister chromatid exchange by diethylstilbesterol in lymphocytes from pregnant and premenopausal women. Cancer Res. 1982; 42: 893
  • Bynum G., Kram D., Dean R., Hadley E., Monticone R., Bickings C., Schneider E. L. Steroid modulation of sister chromatid exchange induction by mitomycin C and UV light. Environ. Mutagen. 1980; 2: 247
  • Mulvihill J. J. Genetic repertory of human neoplasia. Genetics of Human Cancer, J. J. Mulvihill, R. W. Miller, J. F. Fraumeni. Raven Press, New York 1977; 137
  • Guidelines for the Study of Genetic Effects in Human Populations, W.H.O. Environmental Health Criteria, Geneva 1985; 46
  • ISCN, An International System for Human Cytogenetic Nomenclature. D. G. Harnden, H. P. Klinger. Cytogenet. Cell Genet., Karger, Basel 1985
  • Lambert B., Ringborg U., Harper E., Lindblad A. Sister chromatid exchanges in lymphocyte cultures of patients receiving chemotherapy for malignant disorders. Cancer Treat. Rep. 1978; 62: 1413
  • Lambert B., Bredberg A., McKenzie W., Sten M. Sister chromatid exchange in human populations: the effect of smoking, drug treatment, and occupational exposure. Cytogenet. Cell Genet. 1982; 33: 62
  • Murthy P. B. K. Frequency of sister chromatid exchanges in cigarette smokers. Hum. Genet. 1979; 52: 343
  • Crossen P. E., Morgan W. F. Sister chromatid exchange in cigarette smokers. Hum. Genet. 1980; 53: 452
  • Husgafvel-Pursiaininen K., Mäki-Paakkanen J., Norppa H., Sorsa M. Smoking and sister chromatid exchange. Hereditas 1980; 92: 247
  • Hopkin J. M., Evans H. J. Cigarette smoke-induced DNA damage and lung cancer risks. Nature (London) 1980; 283: 388
  • Evans H. J. Cigarette smoke induced DNA damage in man. Prog. Mutat. Res. 1981; 2: 111
  • Husum B., Valentin N., Wulf H. C., Halaburt A., Niebuhr E. Sister chromatid exchanges in cigarette smokers: effects of halothane, isoflurance or subarachnoid blockade. Br. J. Anaesth. 1985; 57: 1100
  • Obe G., Vogt H.-J., Madle S., Fahning A., Heller W. D. Double-blind study on the effect of cigarette smoking on the chromosomes of human peripheral blood lymphocytes in vivo. Mutat. Res. 1982; 92: 309
  • Meiying C., Jiujin X., Xianting Z. Comparative studies on spontaneous and mitomycin-C-induced sister-chromatid exchanges in smokers and nonsmokers. Mutat. Res. 1982; 105: 195
  • Vijayalaxmi, Evans H. J. In vivo and in vitro effects of cigarette smoke on chromosomal damage and sister-chromatid exchange in human peripheral blood lymphocytes. Mutat. Res. 1982; 92: 321
  • Brogger A. Application of SCE to public health. Sister Chromatid Exchange, A. A. Sandberg. Alan R. Liss, New York 1982; 655
  • Lundberg M. S., Livingston G. K. Sister-chromatid exchange frequency in lymphocytes of smoking and nonsmoking mothers and their newborn infants. Mutat. Res. 1983; 121: 241
  • Livingston G. K., Fineman R. M. Correlation of human lymphocyte SCE frequency with smoking history. Mutat. Res. 1983; 119: 59
  • Husgafvel-Pursiainnen K., Sorsa M., Jaerventaus H., Norppa H. Sister-chromatid exchanges in lymphocytes of smokers in an experimental study. Mutat. Res. 1984; 138: 197
  • Hopkin J. M. Sister chromatid exchange induction by cigarette smoke. Basic Life Sci. 1984; 29(Part B)927
  • Watanabe T., Endo A. The SCE test as a tool for cytogenetic monitoring of human exposure to occupational and environmental mutagens. Basic Life Sci. 1984; 29(Part B)939
  • Morimoto K., Miura K., Kaneko T., Ujima K., Sato M., Koizumi A. Human health situation and chromosome alterations: sister chromatid exchange frequency in lymphocytes from passive smokers and patients with hereditary diseases. Basic Life Sci. 1984; 29(Part B)801
  • Wulf H. C., Husum B., Niebuhr E. Cessation of smoking enhances sister chromatid exchanges in lymphocytes. Hereditas 1985; 102: 195
  • Wulf H. C., Husum B., Niebuhr E. Sister chromatid exchanges in smokers of high-tar cigarettes, low-tar cigarettes, cheroots and pipe tobacco. Hereditas 1983; 98: 225
  • Perry P. E., Thomson E. J., Vijayalaxmi Evans H. J., Day N. E., Bartsch H. Induction of SCE by opium pyrolysates in CHO cells and human peripheral blood lymphocytes. Carcinogenesis 1983; 4: 227
  • Adbvaryu S. G., Bhatt R. G., Dayal P. K., Trivedi A. H., Davi B. J., Vyas R. C., Jani K. H. SCE frequencies in lymphocytes of tobacco/betel nut chewers and patients with oral submucous fibrosis. Br. J. Cancer 1986; 53: 141
  • Hoeft H., Obe G. SCE-inducing congeners in alcoholic beverages. Mutat. Res. 1983; 121: 247
  • Dozi-Vassiliades J., Mourelatos D., Myrtsiotis A. Induction of sister-chromatid exchange in human lymphocytes by vitamin B6. Mutat. Res. 1983; 124: 175
  • Dozi-Vassiliades J., Myrtsiotis A., Granitsas A., Mourelatos D. Induction of sister-chromatid exchanges and cell-cycle delays in human lymphocytes by vitamin A alone or in combination with melphalan and caffeine. Eur. J. Cancer Clin. Oncol 1985; 21: 1089
  • Mutchinick O., Lisker R., Ruz L., Salamanca F., Armendares S. Frequency of sister chromatid exchanges in severe protein calorie malnutrition. Ann. Genet. 1979; 22: 129
  • Murthy P. B., Bhaskaran P., Srikantia S. G. Sister chromatid exchanges in protein-energy malnutrition. Hum. Genet. 1980; 55: 405
  • Murthy P. B., Srikantia S. G. SCE frequency in malnourished mice. Metabolism 1981; 30: 1
  • Bentancourt M., Balvanera P., Ortiz R. Frequency of sister chromatid exchange (SCE) in bone marrow cells of severely malnourished animals during early life. Mutat. Res. 1986; 175: 29
  • Giri A. K., Talukdar G., Sharma A. Sister chromatid exchange induced by metanil yellow and nitrite singly and in combination in vivo in mice. Cancer Lett. 1986; 31: 299
  • Wolff S., Rodin B. Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells. Science 1978; 200: 543
  • Jansson T., Zech L. Effects of vanillin on sister chromatid exchanges and chromosome aberrations in human lymphocytes. Mutat. Res. 1987; 190: 221
  • Murthy P. B., Prema K. Further studies on sister-chromatid exchange frequency in users of hormonal contraceptives. Mutat. Res. 1983; 119: 351
  • Ostrosky-Wegman P., Garcia G., Arellano L., Espinosa J. J., Montero R., Cortinas de Nava C. Genotoxicity of antiamoebic onthelmintic, and antimycotic drugs in human lymphocytes. Basic Life Sci. 1984; 29(Part B)915
  • Tsui Y. C., Creasy M. R., Hulten M. A. The effect of the male contraceptive agent Gossypol on human lymphocytes in vitro: traditional chromosome breakage, micronuclei, sister chromatid exchange, and cell kinetics. J. Med. Genet. 1983; 20: 81
  • Shen Y. Sister chromatid exchange in lymphocytes of peripheral blood in women injected with two steroid hormonal contraceptives. Chung Hua Fu Ch an K o Tsa Chih 1986; 21: 35
  • Erksine I. E., Mackay J. M., Fox D. P. Monitoring patients on long-term drug therapy for genotoxic effects. Basic Life Sci. 1984; 29(Part B)895
  • Spelt G., Haupter S. Cytogenetic effects of penicilliamine. Mutat. Res. 1987; 190: 197
  • Mackay J. M., Fox D. P., Brunt P. W., Johnston A. W. Increased sister-chromatid exchange frequency in patients receiving sulphasalazine therapy for ulcerative colitis. Mutat. Res. 1983; 118: 205
  • Kowalczyk J. Sister chromatid exchanges in children treated with nalidixic acid. Mutat. Res. 1980; 77: 371
  • Andersson H. C., Tranberg E. A., Uggla A. H., Zetterberg G. Chromosomal aberrations and sister-chromatid exchanges in lymphocytes of men occupationally exposed to styrene in a plastic-boat factory. Mutat. Res. 1980; 73: 387
  • Uggla A. H., Andersson H. C., Tranberg E. A., Zetterberg L. G. Correlation between exposure to styrene and the frequency of chromosomal aberrations and sister-chromatid exchanges in lymphocytes of workers in a plastic boat factory. Mutat. Res. 1980; 74: 199
  • Watanabe T., Endo A., Kato Y., Shima S., Watanabe T., Ikeda M. Cytogenetics and cytokinetics of cultured lymphocytes from benzene-exposed workers. Int. Arch. Occup. Environ. Health 1980; 46: 31
  • Watanabe T., Endo A., Kumai M., Ikeda M. Chromosome aberrations and sister chromatid exchanges in styrene-exposed workers with reference to their smoking habits. Environ. Mutagen. 1983; 5: 299
  • Camurri L., Codeluppi S., Pedroni C., Scarduelli L. Chromosomal aberrations and sister-chromatid exchanges in workers exposed to styrene. Mutat. Res. 1983; 119: 361
  • Camurri L., Codeluppi S., Scarduelli L., Candela S. Sister chromatid exchanges in workers exposed to low doses of styrene. Basic Life Sci. 1984; 29(Part B)957
  • Bauchinger M., Schmid E., Dresp J., Kolin-Gerresheiin J., Hauf R., Suhr E. Chromosome changes in lymphocytes after occupational exposure to toluene. Mutat. Res. 1982; 102: 439
  • Mäki-Paakkanen J., Husgafvel-Pursiainen K., Kalliomäki P.-L., Tuominen J., Sorsa M. Toluene-exposed workers and chromosome aberrations. J. Toxicol. Environ. Health 1980; 6: 775
  • Kucerová M., Polívková Z., Bátora J. Comparative evaluation of the frequency and chromosomal aberrations and the SCE numbers in peripheral lymphocytes of workers occupationally exposed to vinyl chloride monomer. Mutat. Res. 1979; 67: 97
  • Mäki-Paakkanen J., Sorsa M., Vainio H. Kromsomaberrationer och SCE i arbetare som exponerats för bly (Chromosome aberrations and SCE in lead exposed workers). Nordiske Yrkeshygieniske Möte i Norge. Yrkeshygienisk Institutt, Oslo 1980; 30, November 3 to 5, 1980
  • Dalpra L., Tibiletti M. G., Nocera G., Giulotto P., Auriti L., Carnelli Y., Simoni G. SCE analysis in children exposed to lead emission from a smelting plant. Mutat. Res. 1983; 120: 249
  • Yager J. W., Conn K. L., Spear R. C., Fisher J. M., Morse L. Sister-chromatid exchanges in lymphocytes of anatomy students exposed to formaldehyde-embalming solution. Mutat. Res. 1986; 174: 135
  • Bauchinger M., Dresp J., Schmid E., Hauf R. Chromosome changes in lymphocytes after occupational exposure to pentachlorphenol (PCP). Mutat. Res. 1982; 102: 83
  • Bauchinger M., Kulka U., Schmid E. Analysis of cytogenetic effects in human lymphocytes induced by metabolically activated 2-nitropropane. Mutat. Res. 1987; 190: 217
  • Hedner K., Högstedt B., Kolnig A.-M., Mark-Vendel E., Stormbeck B., Mitelman F. Sister chromatid exchanges and structural chromosome aberrations in relation to smoking in 91 individuals. Hereditas 1983; 98: 77
  • Mäki-Paakkanen J., Sorsa M., Vainio H. Sister chromatid exchanges and chromosome aberrations in rubber workers. Teratogenesis Carcinog. Mutagen. 1984; 4: 189
  • Tucker J. D., Whong W. Z., Xu J., Ong T. Genotoxic activity of nitrosated coal dust extract in mammalian systems. Environ. Res. 1984; 35: 171
  • Tucker J. D., Ong T. Induction of sister chromatid exchanges by coal dust and tobacco snuff extracts in human peripheral lymphocytes. Environ. Mutagen. 1985; 7: 313
  • Mitra A. B., Das B. C., Murty V. V. V.S., Bhambhani S., Sharma A., Pratap M., Luthra U. K. Cytogenetic effects in individuals exposed to methylisocyanate (MIC) at Bhopal. Indian J. Med. Res.
  • Stoll C., Borgaonkar D. S., Levy J.-M. Effect of vincristine on sister chromatid exchanges of normal human lymphocytes. Cancer Res. 1976; 36: 2710
  • Falck K., Gröhn P., Sorsa M., Vainio H., Heinonen E., Holsti L. R. Mutagenicity in urine of nurses handling cytostatic drugs. Lancet 1979; 1: 1250
  • Husum B., Wutt H. C. Sister chromatid exchanges in lymphocytes in operating room personnel. Acta Anaesthesiol. Scand. 1980; 24: 22
  • Raposa T. SCE induction by cytostatics and its relation to iatrogenic leukemogenesis. Basic Life Sci. 1984; 29(Part B)859
  • Singh N. P., D'Ambrosio S. M. Sister chromatid exchange frequency and cell cycle kinetics in cancer patients treated with cytostatic drugs. Basic Life Sci. 1984; 29(Part B)885
  • Husum B., Wulf H. C., Niebuhr E. Monitoring of sister chromatid exchanges in lymphocytes of nurse-anesthetists. Anesthesiology 1985; 62: 475
  • Waksvik H., Klepp O., Brogger A. Chromosome analyses of nurses handling cytostatic agents. Cancer Treat. Rep. 1981; 65: 607
  • Kato H., Sandberg A. A. Effects of herpes simplex virus on sister chromatid exchange and chromosome abnormalities in human diploid fibroblasts. Exp. Cell Res. 1977; 109: 423
  • Ghosh R., Ghosh P. K. Sister-chromatid exchanges in herpes simplex infection. Mutat. Res. 1983; 119: 303
  • Brown R. L., Crossen P. E. Increased incidence of sister chromatid exchanges in Rauscher-Leukemia-virus infected mouse embryo fibroblasts. Exp. Cell Res. 1976; 103: 418
  • Nichols W. W., Bardt C. I., Toji L. H., Godley M., Segawa M. Induction of sister chromatid exchanges by transformation with simian virus 40. Cancer Res. 1978; 38: 906
  • Kurvink K., Bloomfield C. D., Cervenka J. Sister chromatid exchange in patients with viral disease. Exp. Cell Res. 1978; 113: 450
  • Lambert B., Ehrnst A., Hansson K., Lindblad A., Morad M., Werelius B. Sister chromatid exchange in peripheral lymphocytes of subjects vaccinated against measles. Hum. Genet. 1979; 50: 291
  • Kucerová M., Polívková Z., Matousek V. Chromosomal aberrations and SCE in lymphocytes of children revaccinated against smallpox. Mutat. Res. 1980; 71: 263
  • Knuutila S., Mäki-Paakkanen J., Kähkönen M., Hokkanen E. An increased frequency of chromosomal changes and SCEs in cultured blood lymphocytes of 12 subjects vaccinated against smallpox. Hum. Genet. 1978; 41: 89
  • Banerjee A., Benedict W. F. Production of sister chromatid exchanges by various cancer chemotherapeutic agents. Cancer Res. 1979; 39: 797
  • Jaju M., Jaju M., Ahuja Y. R. Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicyclic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index. Hum. Genet. 1983; 63: 42
  • Jaju M., Jaju M., Ahuja Y. R. Genetic effects of drug interaction in tuberculosis patients and their fate. Teratogenesis Carcinog. Mutagen 1984; 4: 261
  • Jaju M., Jaju M., Ahuja Y. R. Evaluation of genotoxicity of ampicillin and carbenicillin on human lymphocytes in vitro: chromosome aberrations, mitotic index, cell cycle kinetics, satellite associations of acrocentric chromosomes and sister chromatid exchanges. Hum. Toxicol. 1984; 3: 173
  • Chaganti R. S. K., Schonberg S., German J. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 1974; 71: 4508
  • Okey C. H. Quantitative replicon analysis of DNA synthesis in cancer-prone conditions and the defects in Bloom's syndrome. J. Cell Sci. 1979; 40: 125
  • Krepinsky A. B., Rainbow A. J., Heddle J. A. Studies on the ultraviolet light sensitivity of Bloom's syndrome fibroblasts. Mutat. Res. 1980; 59: 357
  • Shirisashi Y., Sandberg A. A. The effect of mitomycin C on normal and Bloom's syndrome cells. Mutat. Res. 1978; 49: 239
  • Schonberg S., German J. Sister chromatid exchange in cells metabolically coupled to Bloom's syndrome cells. Nature (London) 1980; 284: 72
  • Bertram C. R., Koske-Westphal T., Passarge E. Chromatid exchange in ataxia telangiectasia, Bloom's syndrome, Werner's syndrome, and Xeroderma pigmentosum. Ann. Hum. Genet. 1976; 40: 79
  • Schonwald A. D., Passarge E. UV-light-induced sister chromatid exchanges in Xeroderma pigmentosum lymphocytes. Hum. Genet. 1977; 36: 213
  • DeWeerd-Kastelein E. A., Keijzer W., Rainaldi G., Bootsma D. Induction of sister chromatid exchange in Xeroderma pigmentosium cells after exposure to ultraviolet light. Mutat. Res. 1977; 45: 253
  • Cheng W. S., Tarone R. F., Andrews A. D., Whang-Peng J. S., Robins J. H. Ultraviolet light-induced sister chromatid exchanges in Xeroderma pigmentosum and Cockayne's syndrome lymphocyte cell lines. Cancer Res. 1978; 38: 1601
  • Hatcher N. H., Brinson P. S., Hook E. B. Sister chromatid exchanges in ataxia telangiectasia. Mutat. Res. 1976; 35: 333
  • Latt S. A., Stetten G., Juergens L. A., Buchanan G. R., Gerald P. S. Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia. Proc. Natl. Acad. Sci. U.S.A. 1975; 72: 4066
  • Novotna B., Goetz P., Surkova N. I. Effects of alkylating agents on lymphocytes from controls and from patients with Fanconi's anemia. Hum. Genet. 1979; 49: 41
  • Berger R., Bemheim A., Le Coniat M., Vecchione D., Schaison G. Sisterchromatid exchanges induced by nitrogen mustard in Fanconi's anemia, Application to the detection of heterozygotes and interpretation of the results. Cancer Genet. Cytogenet. 1980; 2: 259
  • Knuutila S., Harkki A., Elimäki K., Salunen R. Decreased sister chromatid exchange in Down's syndrome after measles vaccination. Hereditas 1979; 90: 147
  • Palmer R. G., Dore C. J., Denman A. M. Sister chromatid exchange frequencies in lymphocytes of controls and patients with connective tissue diseases. Mutat. Res. 1986; 162: 113
  • Evans H. J. Sister chromatid exchanges and disease stages in man. Sister Chromatid Exchange, S. Wolff. John Wiley & Sons, New York 1982; 183
  • Sandberg A. A., Becher R., Gibas Z. Value and significance of SCE in human leukemia and cancer. Basic Life Sci. 1984; 29(Part B)825
  • Ghidoni A., Privitera E., Raimondi E., Rovini D., Illeni M. T., Cascinelli N. Sister chromatid exchange in phytohaemagglutinin stimulated lymphocytes of nonfamilial cutaneous malignant melanoma patients. Basic Life Sci. 1984, Part B: 855
  • Murty V. V. V.S., Mitra A. B., Luthra U. K., Singh I. P. Sister chromatid exchanges in patients with precancerous and cancerous lesions of the cervix uteri. Hum. Genet. 1986; 72: 37
  • Oikawa A., Horaguchi K., Sugwara R., Kikuchi J., Tohda H., Takahashi K., Wakui A., Yamauchi A., Nakada T. Novel responses of peripheral lymphocytes of cancer patients to chemical induction of sister chromatid exchanges. Cancer Res. 1986; 46: 989
  • Das B. C., unpublished observation
  • Das B. C., unpublished observation

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