Genetic control of de novo lipogenesis: role in diet-induced obesity

References

• Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G and Wakil SJ. 2000. The subcellular localization of acetyl-CoA Carboxylase 2. Proc Natl Acad Sci USA 97:1444–1449.
   PubMed Web of Science ®Google Scholar
• Abu-Elheiga L, Matzuk MM, Abo-Hashema KAH and Wakil SJ. 2001. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA Carboxylase 2. Science 291:2613–2616.
   PubMed Web of Science ®Google Scholar
• Abu-Elheiga L, Oh W, Kordari P and Wakil SJ. 2003. Acetyl-CoA Carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc Natl Acad Sci USA 100:10207–10212.
   PubMed Web of Science ®Google Scholar
• Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z and Wakil SJ. 2005. Mutant mice lacking acetyl-CoA Carboxylase 1 are embryonically lethal. Proc Natl Acad Sci USA 201:12011–12016.
   Google Scholar
• Barrows BR and Parks EJ. 2006. Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J Clin Endocrinol Metab. 91:1446–1452.
   PubMed Web of Science ®Google Scholar
• Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC and Young SG. 2004. ATP-citrate lyase deficiency in the mouse. J Biol Chem. 279:9557–9564.
   PubMed Web of Science ®Google Scholar
• Bergot MO, Diaz-Guerra MJ, Puzenat N, Raymondjean M and Kahn A. 1992. Cis-regulation of the L-type pryruvate kinase gene promoter by glucose, insulin and cyclic AMP. Nuc Acids Res 20:1871–1878.
   PubMedGoogle Scholar
• Bouchard C. 2008 Gene-environment interactions in the etiology of obesity: defining the fundamentals. Obesity 16:S5–S10.
   PubMed Web of Science ®Google Scholar
• Brownsey RW, Boone AN, Elliott JE, Kulpa JE and Lee WM. 2006. Regulation of acetyl-CoA Carboxylase. Biochem Soc Trans 34:223–227.
   PubMed Web of Science ®Google Scholar
• Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM and Hotamisligil GS. 2008. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 134:933–944.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. 2008. Behavioral Risk Factor Surveillance System Survey Data. Atlanta, Georgia: US Department of Health and Human Services. Available at: http://apps.nccd.cdc.gov/brfss/ (accessed 23 July 2009).
   Google Scholar
• Cha JY and Repa JJ. 2007. The liver X receptor (LXR) and hepatic lipogenesis. J Biol Chem 282:743–751.
   PubMed Web of Science ®Google Scholar
• Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J and Semenkovich CF. 2005. “New” hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 1:309–322.
   PubMed Web of Science ®Google Scholar
• Chakravarthy MV, Zhu Y, Lopez M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD and Semenkovich CF. 2007. Brain fatty acid synthase activates PPARα to maintain energy homeostasis. J Clin Invest 117:2539–2552.
   PubMed Web of Science ®Google Scholar
• Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RRV, Xu HE, Turk J and Semenkovich CF. 2009a. Identification of a physiologically relevant endogenous ligand for PPARα in liver. Cell 138:476–488.
   PubMed Web of Science ®Google Scholar
• Chakravarthy MV, Zhu Y, Yin L, Coleman T, Pappan KL, Marshall CA, McDaniel ML and Semenkovich CF. 2009b. Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. J Lipid Res 50:630–640.
   Google Scholar
• Chawla A, Repa JJ, Evans RM and Mangelsdorf DJ. 2001. Nuclear receptors andlipid physiology: opening the X-files. Science 294:1866–1870.
   PubMed Web of Science ®Google Scholar
• Chen G, Liang G, Ou J, Goldstein JL and Brown MS. 2004. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci USA 101:11245–11250.
   PubMed Web of Science ®Google Scholar
• Chen HC, Smith SJ, Tow B, Elias PM and Farese RV Jr. 2002. Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J Clin Invest 109:175–181.
   PubMed Web of Science ®Google Scholar
• Chiral SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M and Wakil SJ. 2003. Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci USA 100:6358–6363.
   Google Scholar
• Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ and Shulman GI. 2007. Continuous fat oxidation in acetyl-CoA Carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci USA 104:16480–16485.
   PubMed Web of Science ®Google Scholar
• Cortes VA, Curtis DE, Sukumaran S, Shao X, Parameswara V, Rashid S, Smith AR, Ren J, Esser V, Hammer RE, Agarwal AK, Horton JD and Garg A. 2009. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab 9:165–176.
   PubMedGoogle Scholar
• Cuif MH, Porteu A, Kahn A and Vaulont S. 1993. Exploration of a liver-specific, glucose/insulin-responsive promoter in transgenic mice. J Biol Chem 268:13769–13772.
   PubMedGoogle Scholar
• Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J and Postic C. 2008. ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest 118:956–964.
   PubMed Web of Science ®Google Scholar
• Dentin R, Benhamed F, Pegorier JP, Foufelle F, Viollet B, Vaulont S, Girard J and Postic C. 2005. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest 115:2843–2854.
   PubMed Web of Science ®Google Scholar
• Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM and Ntambi JM. 2004. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci USA 101:6409–6414.
   PubMed Web of Science ®Google Scholar
• Doiron B, Cuif MH, Chen R and Kahn A. 1996. Transcriptional glucose signaling through the glucose response element is mediated by the pentose phosphate pathway. J Biol Chem 271:5321–5324.
   Google Scholar
• Dowell P, Hu Z and Lane MD. 2005. Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. Annu Rev Biochem 74:515–534.
   PubMed Web of Science ®Google Scholar
• Foretz M, Guichard C, Ferre P and Foufelle F. 1999. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci USA 96:12737–12742.
   PubMed Web of Science ®Google Scholar
• Goldstein JL, DeBose-Boyd RA and Brown MS. 2006. Protein sensors for membrane sterols. Cell 124:35–46.
   PubMed Web of Science ®Google Scholar
• Gutierrez-Juarez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia BP and Rossetti L. 2006. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest 116:1686–1695.
   PubMed Web of Science ®Google Scholar
• Hammond LE, Gallagher PA, Wang S, Hiller S, Kluckman KD, Posey-Marcos EL, Maeda N and Coleman RA. 2002. Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition. Mol Cell Biol. 22:8204–8214.
   PubMed Web of Science ®Google Scholar
• Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM and Coleman RA. 2005. Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. J Biol Chem 280:25629–25636.
   PubMed Web of Science ®Google Scholar
• Hannah VC, Ou J, Luong A, Goldstein JL and Brown MS. 2001. Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells. J Biol Chem 276:4365–4372.
   PubMed Web of Science ®Google Scholar
• Harada N, Oda Z, Hara Y, Fujinami K, Okawa M, Ohbuchi K, Yonemoto M, Ikeda Y, Ohwaki K, Aragane K, Tamai Y and Kusunoki J. 2007. Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol Cell Biol 27:1881–1888.
   PubMed Web of Science ®Google Scholar
• Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL and Shimano H. 1998a. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest 101:2331–2339.
   PubMed Web of Science ®Google Scholar
• Horton JD, Bashmakov Y, Shimomura I and Shimano H. 1998b. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA 95:5987–5992.
   PubMed Web of Science ®Google Scholar
• Horton JD, Goldstein JL and Brown MS. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125–1131.
   PubMed Web of Science ®Google Scholar
• Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS and Goldstein JL. 2003. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 100:12027–12032.
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444:860–867.
   PubMed Web of Science ®Google Scholar
• Hudgins LC, Hellerstein M, Seidman C, Neese R, Diakun J and Hirsch J. 1996. Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. J Clin Invest 97:2081–2091.
   PubMedGoogle Scholar
• Iizuka K, Bruick RK, Liang G, Horton JD and Uyeda K. 2004. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 101:7281–7286.
   PubMed Web of Science ®Google Scholar
• Janowski BA, Willy PJ, Devi TR, Falck JR and Mangelsdorf DJ. 1996. An oxysterol signaling pathway mediated by the nuclear receptor LXRα. Nature 383:728–731.
   PubMed Web of Science ®Google Scholar
• Jiang G, Li Z, Liu F, Ellsworth K, Dallas-Yang Q, Wu M, Ronan J, Esau C, Murphy C, Szalkowski D, Bergeron R, Doebber T and Zhang BB. 2005. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J Clin Invest 115:1030–1038.
   PubMed Web of Science ®Google Scholar
• Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF and Tontonoz P. 2002. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem 277:11019–11025.
   PubMed Web of Science ®Google Scholar
• Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B and Wahli W. 1999. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J Clin Invest 103:1489–1498.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Takahashi M and Ezaki O. 1999. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. J Biol Chem 274:25892–25898.
   PubMed Web of Science ®Google Scholar
• Kim KH. 1997. Regulation of mammalian acetyl-coenzyme A carboxylase. Annu Rev Nutr 17:77–99.
   PubMed Web of Science ®Google Scholar
• Kos CH. 2004 Cre/loxP system for generating tissue-specific knockout mouse models. Nutr Rev 62:243–246.
   PubMed Web of Science ®Google Scholar
• Kumadaki S, Matsuzaka T, Kato T, Yahagi N, Yamamoto T, Okada S, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N and Shimano H. 2008. Mouse Elovl-6 is an SREBP target. Biochem Biophys Res Commun 368:261–266.
   PubMedGoogle Scholar
• Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Colins JL and Tontonoz P. 2001. Autoregulation of the human liver X receptor α promoter. Mol Cell Biol 21:7558–7568.
   PubMed Web of Science ®Google Scholar
• Lee JN, Zhang X, Feramisco JD, Gong Y and Ye J. 2008. Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. J Biol Chem 283:33772–33783.
   Google Scholar
• Lin J, Yang R, Tarr PT, Wu P, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB and Spiegelman BM. 2005a. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1b coactivation of SREBP. Cell 120:261–273.
   PubMed Web of Science ®Google Scholar
• Lin J, Handschin C and Spiegelman BM. 2005b. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1:361–370.
   PubMed Web of Science ®Google Scholar
• Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD and Kuhajda FP. 2000. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288:2379–2381.
   PubMed Web of Science ®Google Scholar
• Lusis AJ, Attie AD and Reue K. 2008. Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet 9:819–830.
   PubMed Web of Science ®Google Scholar
• Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA and Hotamisligil GS. 2005. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab 1:107–119.
   PubMed Web of Science ®Google Scholar
• Magkos F, Yannakoulia M, Chan JL and Mantzoros CS. 2009. Management of the metabolic syndrome and type 2 diabetes through lifestyle modification. Ann Rev Nutr 29:223–256.
   PubMed Web of Science ®Google Scholar
• Mao J, DeMayo FJ, Li H, Abul-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC and Wakil SJ. 2006. Liver-specific deletion of acetyl-CoA Carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci USA 103:8552–8557.
   PubMed Web of Science ®Google Scholar
• Mao J, Yang T, Gu Z, Heird WC, Finegold MJ, Lee B and Wakil SJ. 2009. aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues. Proc Natl Acad Sci USA 106:17576–17581.
   PubMed Web of Science ®Google Scholar
• Matsuzaka T and Shimano H. 2009. Elovl6: a new player in fatty acid metabolism and insulin sensitivity. J Mol Med 87:379–384.
   PubMed Web of Science ®Google Scholar
• Matsuzaka T, Shimano H, Yahagi N, Yoshikawa T, Amemiya-Kudo M, Hasty AH, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Takahashi A, Yato S, Sone H, Ishibashi S and Yamada N. 2002. Cloning and characterization of mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. J Lipid Res 43:911–920.
   PubMed Web of Science ®Google Scholar
• Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J and Yamada N. 2007. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat Med 13:1193–1202.
   PubMed Web of Science ®Google Scholar
• McGarry JD, Leatherman GF and Foster DW 1978. Carnitine Palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA. J Biol Chem 253:4128–4136.
   PubMed Web of Science ®Google Scholar
• Miyazaki M, Man WC and Ntambi JM. 2001. Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J Nutr 131:2260–2268.
   PubMed Web of Science ®Google Scholar
• Miyazaki M, Dobrzyn A, Man WC, Chu K, Sampath H, Kim HJ and Ntambi JM. 2004. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanism. J Biol Chem 279:25164–25171.
   PubMed Web of Science ®Google Scholar
• Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X and Ntambi JM. 2007. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab 6:484–496.
   PubMed Web of Science ®Google Scholar
• Moon YA, Shah NA, Mohapatra S, Warrington JA and Horton JD. 2001. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J Biol Chem 276:45358–45366.
   PubMed Web of Science ®Google Scholar
• Muoio DM and Newgard CB. 2006. Obesity-related derangements in metabolic regulation. Annu Rev Biochem 75:367–401.
   PubMed Web of Science ®Google Scholar
• Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Loffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, Bogan JS, Samuel V and Shulman GI 2009. The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab 9:252–264.
   PubMed Web of Science ®Google Scholar
• Nagle CA, Vergnes L, DeJong H, Wang S, Lewin TM, Reue K and Coleman RA. 2008. Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6–/– mice. J Lipid Res 49:823–831.
   Google Scholar
• Neschen S, Morino K, Hammond LE, Zhang D, Liu ZX, Romanelli AJ, Cline GW, Pongratz RL, Zhang XM, Choi CS, Coleman RA and Shulman GI. 2005. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab 2:55–65.
   PubMed Web of Science ®Google Scholar
• Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM and Attie AD. 2002. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 99:11482–11486.
   PubMed Web of Science ®Google Scholar
• Oh W, Abu-Elheiga L, Kordari P, Gu Z, Shaikenov T, Chirala SS and Wakil SJ. 2005. Glucose and fat metabolism in adipose tissue of acetyl-CoA Carboxylase 2 in knockout mice. Proc Natl Acad Sci USA 102:1384–1389.
   PubMed Web of Science ®Google Scholar
• O’Rahilly S. 2009. Human genetics illuminates the paths to metabolic disease. Nature 462:307–314.
   PubMed Web of Science ®Google Scholar
• Postic C and Girard J. 2008 Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 118:829–838.
   PubMed Web of Science ®Google Scholar
• Postic C, Dentin R, Denechaud PD and Girard J. 2007. ChREBP, a transcriptional regulator of glucose and lipid metabolism. Annu Rev Nutr 27:179–192.
   PubMedGoogle Scholar
• Powell DR. 2006. Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo. Obesity Rev 7:89–108.
   PubMed Web of Science ®Google Scholar
• Qi L and Cho YA. 2008. Gene-environment interaction and obesity. Nutr Rev 66:684–694.
   PubMed Web of Science ®Google Scholar
• Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JA, Shimomura I, Shan B, Brown MS, Goldstein JL and Mangelsdorf DJ. 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptor, LXRα and LXRβ. Genes & Dev 14:2819–2830.
   PubMed Web of Science ®Google Scholar
• Saggerson D. 2008. Malonyl-CoA, a key signaling molecule in mammalian cells. Annu Rev Nutr 28:253–272.
   PubMed Web of Science ®Google Scholar
• Sampath H and Ntambi JM. 2004. Polyunsaturated fatty acid regulation of gene expression. Nutr Rev 62:333–339.
   PubMed Web of Science ®Google Scholar
• Sampath H, Miyazaki M, Dobrzyn A and Ntambi JM. 2007. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem 282:2483–2493.
   PubMed Web of Science ®Google Scholar
• Sampath H, Flowers MT, Liu X, Paton CM, Sullivan R, Chu K, Zhao M and Ntambi JM. 2009. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high-fat diet-induced obesity. J Biol Chem 284:19961–19973.
   PubMed Web of Science ®Google Scholar
• Sauer B. 1998. Inducible gene targeting in mice using the Cre/lox system. Methods 14:381–392.
   PubMed Web of Science ®Google Scholar
• Savage DB, Choii CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP and Shulman GI. 2006. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J Clin Invest 116:817–824.
   PubMed Web of Science ®Google Scholar
• Scherer LJ and Rossi JJ. 2003. Approaches for the sequence-specific knockdown of mRNA. Nat Biotech 21:1457–1465.
   PubMed Web of Science ®Google Scholar
• Shi Y and Burn P. 2004. Lipid metabolic enzymes: emerging drug targets for the treatment of obesity. Nat Rev Drug Discov 3:695–710.
   PubMed Web of Science ®Google Scholar
• Shih MYS, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL and Farese RV Jr. 2009. Retinol esterificiation by DGAT1 is essential for retinoid homeostasis in murine skin. J Biol Chem. 284: 4292–4299.
   Google Scholar
• Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N. 1999. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem 274:35832–35839.
   PubMed Web of Science ®Google Scholar
• Shimomura I, Shimano H, Horton JD, Goldstein JL and Brown MS. 1997. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99:838–845.
   PubMed Web of Science ®Google Scholar
• Shimomura I, Shimano H, Korn BS, Basmakov Y and Horton JD. 1998. Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. J Biol Chem 273:35299–35306.
   PubMed Web of Science ®Google Scholar
• Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS and Goldstein JL. 1999. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci USA 19:3760–3768.
   Google Scholar
• Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS and Goldstein JL. 2000. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6:77–86.
   PubMed Web of Science ®Google Scholar
• Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH and Farese RV Jr. 2000. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet 25:87–90.
   PubMed Web of Science ®Google Scholar
• Song C, Kokontis JM, Hiipakka RA and Liao S. 1994. Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Proc Natl Acad Sci USA 91:10809–10813.
   PubMed Web of Science ®Google Scholar
• Steffensen KR and Gustafsson J. 2004. Putative metabolic effects of the liver X receptor. Diabetes 53:S36–S42.
   PubMed Web of Science ®Google Scholar
• Stoeckman AK, Ma L and Towle HC. 2004. Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem 279:15662–15669.
   PubMed Web of Science ®Google Scholar
• Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM and Farese RV Jr. 2004. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem 279:11767–11776.
   PubMed Web of Science ®Google Scholar
• Stulnig TM, Steffensen KR, Gao H, Reimers M, Dahlman-Wright K, Schuster GU and Gustafsson J. 2002. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol Pharmacol 62:1299–1305.
   PubMed Web of Science ®Google Scholar
• Tobin KAR, Steineger HH, Alberti S, Spydevold O, Auwerx J, Gustafsson JA and Nebb HI. 2000. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-α. Mol Endocrinol 14:741–752.
   PubMed Web of Science ®Google Scholar
• Tsatsos NG and Towle. 2006. Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism. Biochem Biophys Res Commun 340:449–456.
   PubMedGoogle Scholar
• Vergnes L, Beigneux AP, Davis R, Watkins SM, Young SG and Reue K. 2006. Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J Lipid Res 47:745–754.
   PubMed Web of Science ®Google Scholar
• Wakil SJ and Abu-Elheiga LA. 2009. Fatty acid metabolism: target for metabolic syndrome. J Lipid Res 50:S138–S143.
   PubMed Web of Science ®Google Scholar
• Willy PJ,Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ. 1995. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes & Dev 9:1033–1045.
   PubMed Web of Science ®Google Scholar
• Wolfgang MJ and Lane MD. 2006. Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system. Annu Rev Nutr 26:23–44.
   PubMed Web of Science ®Google Scholar
• Worgall TS, Sturley SL, Seo T, Osborne TF and Deckelbaum RJ. 1998. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J Biol Chem 273:25537–25540.
   PubMed Web of Science ®Google Scholar
• Xu J, Nakamura MT, Cho HP and Clarke SD. 1999. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. J Biol Chem 274:23577–23583.
   PubMed Web of Science ®Google Scholar
• Xu J, Cho H, O’Malley S, Park JHY and Clarke SD. 2002. Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. J Nutr 132:3333–3339.
   Web of Science ®Google Scholar
• Yamashita H, Takenoshita M, Sakurai M, Bruick RK, Henzel WJ, Shillinglaw W, Arnot D and Uyeda K. 2001. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver Proc Natl Acad Sci USA 98:9116–9121.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Eilertsen KJ, Ge L, Zhang L, Sundberg JP, Prouty SM, Stenn KS and Parimoo S. 1999. Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse. Nat Genet 23:268–270.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Prouty SM, Harmon A, Sundberg JP, Stenn KS and Parimoo S. 2001. Scd3—A novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Genomics 71:182–191.
   PubMed Web of Science ®Google Scholar