Sus1/ENY2: a multitasking protein in eukaryotic gene expression

References

• Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S, Dent SY. 2009. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell 35:352–364.
   PubMed Web of Science ®Google Scholar
• Atanassov BS, Koutelou E, Dent SY. 2011. The role of deubiquitinating enzymes in chromatin regulation. FEBS Lett 585:2016–2023.
   PubMed Web of Science ®Google Scholar
• Baker SP, Grant PA. 2007. The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene 26:5329–5340.
   PubMed Web of Science ®Google Scholar
• Balagopal V, Fluch L, Nissan T. 2012. Ways and means of eukaryotic mRNA decay. Biochim Biophys Acta 1819:593–603.
   Google Scholar
• Balagopal V, Parker R. 2009. Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs. Curr Opin Cell Biol 21:403–408.
   PubMed Web of Science ®Google Scholar
• Bermejo R, Capra T, Jossen R, Colosio A, Frattini C, Carotenuto W, Cocito A, Doksani Y, Klein H, Gómez-González B, Aguilera A, Katou Y, Shirahige K, Foiani M. 2011. The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell 146:233–246.
   PubMedGoogle Scholar
• Bermejo R, Lai MS, Foiani M. 2012. Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription. Mol Cell 45:710–718.
   PubMed Web of Science ®Google Scholar
• Bonnet J, Wang YH, Spedale G, Atkinson RA, Romier C, Hamiche A, Pijnappel WW, Timmers HT, Tora L, Devys D, Kieffer B. 2010. The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties. EMBO Rep 11:612–618.
   Google Scholar
• Brengues M, Parker R. 2007. Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae. Mol Biol Cell 18:2592–2602.
   PubMed Web of Science ®Google Scholar
• Brickner JH. 2009. Transcriptional memory at the nuclear periphery. Curr Opin Cell Biol 21:127–133.
   PubMedGoogle Scholar
• Brickner JH, Walter P. 2004. Gene recruitment of the activated INO1 locus to the nuclear membrane. PLoS Biol 2:e342.
   PubMed Web of Science ®Google Scholar
• Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CD. 1996. Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84:843–851.
   PubMed Web of Science ®Google Scholar
• Buchan JR, Parker R. 2009. Eukaryotic stress granules: the ins and outs of translation. Mol Cell 36:932–941.
   PubMed Web of Science ®Google Scholar
• Byers PH, Steiner RD. 1992. Osteogenesis imperfecta. Annu Rev Med 43:269–282.
   PubMed Web of Science ®Google Scholar
• Cabal GG, Genovesio A, Rodriguez-Navarro S, Zimmer C, Gadal O, Lesne A, Buc H, Feuerbach-Fournier F, Olivo-Marin JC, Hurt EC, Nehrbass U. 2006. SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope. Nature 441:770–773.
   PubMed Web of Science ®Google Scholar
• Cancel G, Duyckaerts C, Holmberg M, Zander C, Yvert G, Lebre AS, Ruberg M, Faucheux B, Agid Y, Hirsch E, Brice A. 2000. Distribution of ataxin-7 in normal human brain and retina. Brain 123 Pt 12:2519–2530.
   Google Scholar
• Carmody SR, Wente SR. 2009. mRNA nuclear export at a glance. J Cell Sci 122:1933–1937.
   PubMed Web of Science ®Google Scholar
• Corces VG, Geyer PK. 1991. Interactions of retrotransposons with the host genome: the case of the gypsy element of Drosophila. Trends Genet 7:86–90.
   PubMedGoogle Scholar
• Cuenca-Bono B, García-Molinero V, Pascual-García P, Dopazo H, Llopis A, Vilardell J, Rodríguez-Navarro S. 2011. SUS1 introns are required for efficient mRNA nuclear export in yeast. Nucleic Acids Res 39:8599–8611.
   Google Scholar
• Cuenca-Bono B, García-Molinero V, Pascual-García P, García-Oliver E, Llopis A, Rodríguez-Navarro S. 2010. A novel link between Sus1 and the cytoplasmic mRNA decay machinery suggests a broad role in mRNA metabolism. BMC Cell Biol 11:19.
   PubMed Web of Science ®Google Scholar
• Chekanova JA, Abruzzi KC, Rosbash M, Belostotsky DA. 2008. Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14:66–77.
   PubMed Web of Science ®Google Scholar
• Choder M. 2011. mRNA imprinting: Additional level in the regulation of gene expression. Cell Logist 1:37–40.
   PubMedGoogle Scholar
• Dames P, Weise M, Puff R, Göke B, Parhofer KG, Seissler J, Lechner A. 2012. Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells. Exp Diabetes Res 2012:460869.
   Google Scholar
• David G, Dürr A, Stevanin G, Cancel G, Abbas N, Benomar A, Belal S, Lebre AS, Abada-Bendib M, Grid D, Holmberg M, Yahyaoui M, Hentati F, Chkili T, Agid Y, Brice A. 1998. Molecular and clinical correlations in autosomal dominant cerebellar ataxia with progressive macular dystrophy (SCA7). Hum Mol Genet 7:165–170.
   PubMed Web of Science ®Google Scholar
• Domínguez-Sánchez MS, Barroso S, Gómez-González B, Luna R, Aguilera A. 2011. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. PLoS Genet 7:e1002386.
   PubMed Web of Science ®Google Scholar
• Dunn EF, Hammell CM, Hodge CA, Cole CN. 2005. Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export. Genes Dev 19:90–103.
   PubMedGoogle Scholar
• Ellisdon AM, Dimitrova L, Hurt E, Stewart M. 2012. Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex. Nat Struct Mol Biol 19:328–336.
   PubMed Web of Science ®Google Scholar
• Erickson SL, Lykke-Andersen J. 2011. Cytoplasmic mRNP granules at a glance. J Cell Sci 124:293–297.
   PubMed Web of Science ®Google Scholar
• Espinosa JM. 2008. Histone H2B ubiquitination: the cancer connection. Genes Dev 22:2743–2749.
   PubMed Web of Science ®Google Scholar
• Faza MB, Kemmler S, Jimeno S, González-Aguilera C, Aguilera A, Hurt E, Panse VG. 2009. Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery. J Cell Biol 184:833–846.
   PubMed Web of Science ®Google Scholar
• Fischer T, Rodríguez-Navarro S, Pereira G, Rácz A, Schiebel E, Hurt E. 2004. Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery. Nat Cell Biol 6:840–848.
   PubMed Web of Science ®Google Scholar
• Fischer T, Strässer K, Rácz A, Rodriguez-Navarro S, Oppizzi M, Ihrig P, Lechner J, Hurt E. 2002. The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21:5843–5852.
   PubMed Web of Science ®Google Scholar
• Fleming AB, Kao CF, Hillyer C, Pikaart M, Osley MA. 2008. H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation. Mol Cell 31:57–66.
   PubMed Web of Science ®Google Scholar
• Franks TM, Lykke-Andersen J. 2008. The control of mRNA decapping and P-body formation. Mol Cell 32:605–615.
   PubMed Web of Science ®Google Scholar
• Fujimura S, Xing Y, Takeya M, Yamashita Y, Ohshima K, Kuwahara K, Sakaguchi N. 2005. Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis. Cancer Res 65:5925–5934.
   PubMed Web of Science ®Google Scholar
• Gallardo M, Luna R, Erdjument-Bromage H, Tempst P, Aguilera A. 2003. Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278:24225–24232.
   PubMed Web of Science ®Google Scholar
• Garcia-Lopez A, Monferrer L, Garcia-Alcover I, Vicente-Crespo M, Alvarez-Abril MC, Artero RD. 2008. Genetic and chemical modifiers of a CUG toxicity model in Drosophila. PLoS ONE 3:e1595.
   Google Scholar
• García-Oliver E, García-Molinero V, Rodríguez-Navarro S. 2012. mRNA export and gene expression: The SAGA-TREX-2 connection. Biochim Biophys Acta 1819:555–565.
   PubMedGoogle Scholar
• Garden GA, La Spada AR. 2008. Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration. Cerebellum 7:138–149.
   Google Scholar
• Gaszner M, Felsenfeld G. 2006. Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet 7:703–713.
   PubMed Web of Science ®Google Scholar
• Georgiev PG, Gerasimova TI. 1989. Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster. Mol Gen Genet 220:121–126.
   PubMedGoogle Scholar
• Georgieva S, Nabirochkina E, Dilworth FJ, Eickhoff H, Becker P, Tora L, Georgiev P, Soldatov A. 2001. The novel transcription factor e(y)2 interacts with TAF(II)40 and potentiates transcription activation on chromatin templates. Mol Cell Biol 21:5223–5231.
   PubMedGoogle Scholar
• Gerasimova TI, Gdula DA, Gerasimov DV, Simonova O, Corces VG. 1995. A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. Cell 82:587–597.
   PubMedGoogle Scholar
• Gerich JE. 2003. Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus. Mayo Clin Proc 78:447–456.
   PubMed Web of Science ®Google Scholar
• Ghosh D, Gerasimova TI, Corces VG. 2001. Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function. EMBO J 20:2518–2527.
   PubMedGoogle Scholar
• Glinsky GV, Berezovska O, Glinskii AB. 2005. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 115:1503–1521.
   PubMed Web of Science ®Google Scholar
• Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG. 1996. Life with 6000 genes. Science 274:546, 563–546, 567.
   PubMed Web of Science ®Google Scholar
• González-Aguilera C, Tous C, Gómez-González B, Huertas P, Luna R, Aguilera A. 2008. The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability. Mol Biol Cell 19:4310–4318.
   PubMed Web of Science ®Google Scholar
• Govind CK, Zhang F, Qiu H, Hofmeyer K, Hinnebusch AG. 2007. Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions. Mol Cell 25:31–42.
   PubMed Web of Science ®Google Scholar
• Grüter P, Tabernero C, von Kobbe C, Schmitt C, Saavedra C, Bachi A, Wilm M, Felber BK, Izaurralde E. 1998. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol Cell 1:649–659.
   PubMed Web of Science ®Google Scholar
• Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjöld ML. 2001. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. Mol Cell Biol 21:2545–2554.
   PubMed Web of Science ®Google Scholar
• Gwizdek C, Iglesias N, Rodriguez MS, Ossareh-Nazari B, Hobeika M, Divita G, Stutz F, Dargemont C. 2006. Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription. Proc Natl Acad Sci USA 103:16376–16381.
   PubMedGoogle Scholar
• Harel-Sharvit L, Eldad N, Haimovich G, Barkai O, Duek L, Choder M. 2010. RNA polymerase II subunits link transcription and mRNA decay to translation. Cell 143:552–563.
   PubMed Web of Science ®Google Scholar
• Harris PJ, Speranza G, Dansky Ullmann C. 2012. Targeting embryonic signaling pathways in cancer therapy. Expert Opin Ther Targets 16:131–145.
   Web of Science ®Google Scholar
• Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF, Pillus L, Shilatifard A, Osley MA, Berger SL. 2003. Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev 17:2648–2663.
   PubMed Web of Science ®Google Scholar
• Hossain MA, Rodriguez CM, Johnson TL. 2011. Key features of the two-intron Saccharomyces cerevisiae gene SUS1 contribute to its alternative splicing. Nucleic Acids Res 39:8612–8627.
   PubMed Web of Science ®Google Scholar
• Hoyle NP, Castelli LM, Campbell SG, Holmes LE, Ashe MP. 2007. Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies. J Cell Biol 179:65–74.
   PubMed Web of Science ®Google Scholar
• Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. 2009. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev 23:837–848.
   PubMed Web of Science ®Google Scholar
• Hurt JA, Silver PA. 2008. mRNA nuclear export and human disease. Dis Model Mech 1:103–108.
   PubMedGoogle Scholar
• Ingvarsdottir K, Krogan NJ, Emre NC, Wyce A, Thompson NJ, Emili A, Hughes TR, Greenblatt JF, Berger SL. 2005. H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex. Mol Cell Biol 25:1162–1172.
   PubMed Web of Science ®Google Scholar
• Jani D, Lutz S, Hurt E, Laskey RA, Stewart M, Wickramasinghe VO. 2012. Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. Nucleic Acids Res 40:4562–4573.
   PubMed Web of Science ®Google Scholar
• Johnson C, Primorac D, McKinstry M, McNeil J, Rowe D, Lawrence JB. 2000. Tracking COL1A1 RNA in osteogenesis imperfecta. splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain. J Cell Biol 150:417–432.
   PubMed Web of Science ®Google Scholar
• Jones PA, Baylin SB. 2007. The epigenomics of cancer. Cell 128:683–692.
   PubMed Web of Science ®Google Scholar
• Katahira J. 2012. mRNA export and the TREX complex. Biochim Biophys Acta 1819:507–513.
   PubMedGoogle Scholar
• Katahira J, Strässer K, Podtelejnikov A, Mann M, Jung JU, Hurt E. 1999. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J 18:2593–2609.
   PubMed Web of Science ®Google Scholar
• Köhler A, Pascual-García P, Llopis A, Zapater M, Posas F, Hurt E, Rodríguez-Navarro S. 2006. The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11. Mol Biol Cell 17:4228–4236.
   PubMed Web of Science ®Google Scholar
• Köhler A, Schneider M, Cabal GG, Nehrbass U, Hurt E. 2008. Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export. Nat Cell Biol 10:707–715.
   PubMedGoogle Scholar
• Köhler A, Zimmerman E, Schneider M, Hurt E, Zheng N. 2010. Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module. Cell 141:606–617.
   PubMedGoogle Scholar
• Kopytova DV, Krasnov AN, Orlova AV, Gurskiy DY, Nabirochkina EN, Georgieva SG, Shidlovskii YV. 2010. ENY2: couple, triple.more? Cell Cycle 9:479–481.
   PubMed Web of Science ®Google Scholar
• Kopytova DV, Orlova AV, Krasnov AN, Gurskiy DY, Nikolenko JV, Nabirochkina EN, Shidlovskii YV, Georgieva SG. 2010b. Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. Genes Dev 24:86–96.
   PubMed Web of Science ®Google Scholar
• Koutelou E, Hirsch CL, Dent SY. 2010. Multiple faces of the SAGA complex. Curr Opin Cell Biol 22:374–382.
   PubMed Web of Science ®Google Scholar
• Krasnov AN, Kurshakova MM, Ramensky VE, Mardanov PV, Nabirochkina EN, Georgieva SG. 2005. A retrocopy of a gene can functionally displace the source gene in evolution. Nucleic Acids Res 33:6654–6661.
   PubMedGoogle Scholar
• Kurshakova M, Maksimenko O, Golovnin A, Pulina M, Georgieva S, Georgiev P, Krasnov A. 2007. Evolutionarily conserved E(y)2/Sus1 protein is essential for the barrier activity of Su(Hw)-dependent insulators in Drosophila. Mol Cell 27:332–338.
   PubMed Web of Science ®Google Scholar
• Lang G, Bonnet J, Umlauf D, Karmodiya K, Koffler J, Stierle M, Devys D, Tora L. 2011. The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements. Mol Cell Biol 31:3734–3744.
   PubMed Web of Science ®Google Scholar
• Leahy JL, Hirsch IB, Peterson KA, Schneider D. 2010. Targeting beta-cell function early in the course of therapy for type 2 diabetes mellitus. J Clin Endocrinol Metab 95:4206–4216.
   PubMed Web of Science ®Google Scholar
• Lee KK, Florens L, Swanson SK, Washburn MP, Workman JL. 2005. The deubiquitylation activity of Ubp8 is dependent upon Sgf11 and its association with the SAGA complex. Mol Cell Biol 25:1173–1182.
   PubMed Web of Science ®Google Scholar
• Lee KK, Sardiu ME, Swanson SK, Gilmore JM, Torok M, Grant PA, Florens L, Workman JL, Washburn MP. 2011. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Mol Syst Biol 7:503.
   PubMedGoogle Scholar
• Lee KK, Swanson SK, Florens L, Washburn MP, Workman JL. 2009. Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes. Epigenetics Chromatin 2:2.
   PubMedGoogle Scholar
• Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG, Yan Q. 2011. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci USA 108:13379–13386.
   PubMed Web of Science ®Google Scholar
• Lindenberg KS, Yvert G, Müller K, Landwehrmeyer GB. 2000. Expression analysis of ataxin-7 mRNA and protein in human brain: evidence for a widespread distribution and focal protein accumulation. Brain Pathol 10:385–394.
   Google Scholar
• Lotan R, Goler-Baron V, Duek L, Haimovich G, Choder M. 2007. The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms. J Cell Biol 178:1133–1143.
   PubMed Web of Science ®Google Scholar
• Lu Q, Tang X, Tian G, Wang F, Liu K, Nguyen V, Kohalmi SE, Keller WA, Tsang EW, Harada JJ, Rothstein SJ, Cui Y. 2010. Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin. Plant J 61:259–270.
   PubMed Web of Science ®Google Scholar
• Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ. 1997. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389:251–260.
   PubMed Web of Science ®Google Scholar
• Luna R, Gaillard H, González-Aguilera C, Aguilera A. 2008. Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus. Chromosoma 117:319–331.
   PubMed Web of Science ®Google Scholar
• McCullough SD, Grant PA. 2010. Histone acetylation, acetyltransferases, and ataxia–alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders. Adv Protein Chem Struct Biol 79:165–203.
   Google Scholar
• McMahon SJ, Pray-Grant MG, Schieltz D, Yates JR, Grant PA. 2005. Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity. Proc Natl Acad Sci USA 102:8478–8482.
   PubMed Web of Science ®Google Scholar
• Meetoo D, McGovern P, Safadi R. 2007. An epidemiological overview of diabetes across the world. Br J Nurs 16:1002–1007.
   PubMedGoogle Scholar
• Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, (eds). (2012). Williams Textbook of Endocrinology. 12th edition, Philadelphia: Saunders.
   Google Scholar
• Nagy Z, Tora L. 2007. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Oncogene 26:5341–5357.
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Tagawa K, Oka T, Sasabe T, Ito H, Shiwaku H, La Spada AR, Okazawa H. 2012. Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network. Hum Mol Genet 21:1099–1110.
   Google Scholar
• Niederacher G, Klopf E, Schüller C. 2011. Interplay of dynamic transcription and chromatin remodeling: lessons from yeast. Int J Mol Sci 12:4758–4769.
   Google Scholar
• Oliver SG. 1996. From DNA sequence to biological function. Nature 379:597–600.
   PubMed Web of Science ®Google Scholar
• Orr HT, Zoghbi HY. 2007. Trinucleotide repeat disorders. Annu Rev Neurosci 30:575–621.
   PubMed Web of Science ®Google Scholar
• Pai CY, Lei EP, Ghosh D, Corces VG. 2004. The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Mol Cell 16:737–748.
   PubMedGoogle Scholar
• Palhan VB, Chen S, Peng GH, Tjernberg A, Gamper AM, Fan Y, Chait BT, La Spada AR, Roeder RG. 2005. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci USA 102:8472–8477.
   PubMed Web of Science ®Google Scholar
• Pascual-García P, Govind CK, Queralt E, Cuenca-Bono B, Llopis A, Chavez S, Hinnebusch AG, Rodríguez-Navarro S. 2008. Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2. Genes Dev 22:2811–2822.
   PubMed Web of Science ®Google Scholar
• Pascual-García P, Rodríguez-Navarro S. 2009. A tale of coupling, Sus1 function in transcription and mRNA export. RNA Biol 6:141–144.
   Web of Science ®Google Scholar
• Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A, Reinberg D. 2006. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell 125:703–717.
   PubMed Web of Science ®Google Scholar
• Perales R, Bentley D. 2009. “Cotranscriptionality”: the transcription elongation complex as a nexus for nuclear transactions. Mol Cell 36:178–191.
   PubMed Web of Science ®Google Scholar
• Pérez-Ortín JE, de Miguel-Jiménez L, Chávez S. 2012. Genome-wide studies of mRNA synthesis and degradation in eukaryotes. Biochim Biophys Acta 1819:604–615.
   PubMedGoogle Scholar
• Phatnani HP, Greenleaf AL. 2006. Phosphorylation and functions of the RNA polymerase II CTD. Genes Dev 20:2922–2936.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Navarro S, Igual JC, Pérez-Ortín JE. 2002a. SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19:43–54.
   PubMedGoogle Scholar
• Rodríguez-Navarro S, Strässer K, Hurt E. 2002b. An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast. EMBO Rep 3:438–442.
   Google Scholar
• Rodríguez-Navarro S, Fischer T, Luo MJ, Antúnez O, Brettschneider S, Lechner J, Pérez-Ortín JE, Reed R, Hurt E. 2004. Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell 116:75–86.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Navarro S. 2009. Insights into SAGA function during gene expression. EMBO Rep 10:843–850.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Navarro S, Hurt E. 2011. Linking gene regulation to mRNA production and export. Curr Opin Cell Biol 23:302–309.
   PubMed Web of Science ®Google Scholar
• Rougvie AE, Lis JT. 1988. The RNA polymerase II molecule at the 5’ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged. Cell 54:795–804.
   PubMed Web of Science ®Google Scholar
• Ruiz-Vela A, Aguilar-Gallardo C, Simón C. 2009. Building a framework for embryonic microenvironments and cancer stem cells. Stem Cell Rev 5:319–327.
   PubMed Web of Science ®Google Scholar
• Saguez C, Schmid M, Olesen JR, Ghazy MA, Qu X, Poulsen MB, Nasser T, Moore C, Jensen TH. 2008. Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Mol Cell 31:91–103.
   PubMedGoogle Scholar
• Samara NL, Datta AB, Berndsen CE, Zhang X, Yao T, Cohen RE, Wolberger C. 2010. Structural insights into the assembly and function of the SAGA deubiquitinating module. Science 328:1025–1029.
   PubMedGoogle Scholar
• Segref A, Sharma K, Doye V, Hellwig A, Huber J, Lührmann R, Hurt E. 1997. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J 16:3256–3271.
   PubMed Web of Science ®Google Scholar
• Strässer K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondón AG, Aguilera A, Struhl K, Reed R, Hurt E. 2002. TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417:304–308.
   PubMed Web of Science ®Google Scholar
• Ström AL, Jonasson J, Hart P, Brännström T, Forsgren L, Holmberg M. 2002. Cloning and expression analysis of the murine homolog of the spinocerebellar ataxia type 7 (SCA7) gene. Gene 285:91–99.
   Google Scholar
• Suter DM, Molina N, Naef F, Schibler U. 2011. Origins and consequences of transcriptional discontinuity. Curr Opin Cell Biol 23:657–662.
   Google Scholar
• Tsai HC, Baylin SB. 2011. Cancer epigenetics: linking basic biology to clinical medicine. Cell Res 21:502–517.
   PubMed Web of Science ®Google Scholar
• Tutucci E, Stutz F. 2011. Keeping mRNPs in check during assembly and nuclear export. Nat Rev Mol Cell Biol 12:377–384.
   PubMed Web of Science ®Google Scholar
• Venancio TM, Balaji S, Iyer LM, Aravind L. 2009. Reconstructing the ubiquitin network: cross-talk with other systems and identification of novel functions. Genome Biol 10:R33.
   Google Scholar
• Vitaliano-Prunier A, Babour A, Hérissant L, Apponi L, Margaritis T, Holstege FC, Corbett AH, Gwizdek C, Dargemont C. 2012. H2B ubiquitylation controls the formation of export-competent mRNP. Mol Cell 45:132–139.
   Google Scholar
• Weake VM, Workman JL. 2008. Histone ubiquitination: triggering gene activity. Mol Cell 29:653–663.
   PubMed Web of Science ®Google Scholar
• Weake VM, Workman JL. 2012. SAGA function in tissue-specific gene expression. Trends Cell Biol 22:177–184.
   PubMedGoogle Scholar
• Wickramasinghe VO, McMurtrie PI, Mills AD, Takei Y, Penrhyn-Lowe S, Amagase Y, Main S, Marr J, Stewart M, Laskey RA. 2010. mRNA export from mammalian cell nuclei is dependent on GANP. Curr Biol 20:25–31.
   PubMed Web of Science ®Google Scholar
• Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. 2008. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell 32:735–746.
   PubMed Web of Science ®Google Scholar
• Wissmann M, Yin N, Müller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Günther T, Buettner R, Metzger E, Schüle R. 2007. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol 9:347–353.
   PubMed Web of Science ®Google Scholar
• Woychik NA, Hampsey M. 2002. The RNA polymerase II machinery: structure illuminates function. Cell 108:453–463.
   PubMed Web of Science ®Google Scholar
• Wu PY, Ruhlmann C, Winston F, Schultz P. 2004. Molecular architecture of the S. cerevisiae SAGA complex. Mol Cell 15:199–208.
   PubMed Web of Science ®Google Scholar
• Wyce A, Xiao T, Whelan KA, Kosman C, Walter W, Eick D, Hughes TR, Krogan NJ, Strahl BD, Berger SL. 2007. H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell 27:275–288.
   PubMed Web of Science ®Google Scholar
• Xiao T, Kao CF, Krogan NJ, Sun ZW, Greenblatt JF, Osley MA, Strahl BD. 2005. Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol Cell Biol 25:637–651.
   PubMed Web of Science ®Google Scholar
• Xue-Franzén Y, Johnsson A, Brodin D, Henriksson J, Bürglin TR, Wright AP. 2010. Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles. BMC Genomics 11:200.
   Google Scholar
• Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. 2004. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol 24:5639–5649.
   PubMed Web of Science ®Google Scholar
• Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB. 2008. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell 29:102–111.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Lang G, Ito S, Bonnet J, Metzger E, Sawatsubashi S, Suzuki E, Le Guezennec X, Stunnenberg HG, Krasnov A, Georgieva SG, Schüle R, Takeyama K, Kato S, Tora L, Devys D. 2008. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell 29:92–101.
   PubMed Web of Science ®Google Scholar
• Zhou W, Wang X, Rosenfeld MG. 2009. Histone H2A ubiquitination in transcriptional regulation and DNA damage repair. Int J Biochem Cell Biol 41:12–15.
   PubMedGoogle Scholar