Glutathione Transferases and Cancer

References

• Farber E., Cameron R. The sequential analysis of cancer development. Adv. Cancer Res. 1980; 31: 125
   PubMedGoogle Scholar
• Farber E. Cellular biochemistry of the stepwise development of cancer with chemicals. Cancer Res. 1984; 44: 5463
   PubMed Web of Science ®Google Scholar
• Jakoby W. B. The glutathione S-transferases: a group of multifunctional detoxification proteins. Adv. Enzymol. 1978; 46: 383
   PubMedGoogle Scholar
• Mannervik B. The isoenzymes of glutathione transferase. Adv. Enzymol. Relat. Areas Mol. Biol. 1985; 57: 357
   PubMedGoogle Scholar
• Pickett C. B., Lu A. Y. H. Glutathione S-transferases: gene structure, regulation, and biological function. Annu. Rev. Biochem. 1989; 58: 743
   PubMed Web of Science ®Google Scholar
• Coles B., Ketterer B. The role of glutathione and glutathione transferases in chemical carcinogenesis. CRC Crit. Rev. Biochem. Mol. Biol. 1990; 25: 47
   PubMed Web of Science ®Google Scholar
• Boyland E., Chasseaud L. F. The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis. Adv. Enzymol. 1969; 32: 173
   PubMedGoogle Scholar
• Chasseaud L. F. The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv. Cancer Res. 1979; 29: 175
   PubMedGoogle Scholar
• Smith G. J., Ohl V. S., Litwack G. Ligandin, the glutathione S-transferases, and chemically induced hepatocarcinogenesis: a review. Cancer Res. 1977; 37: 8
   PubMed Web of Science ®Google Scholar
• Wattenberg L. W. Chemoprevention of cancer. Cancer Res. 1985; 45: 1
   PubMed Web of Science ®Google Scholar
• Sato K. Glutathione S-transferases and hepatocarcinogenesis. Jpn. J. Cancer Res. (Gann) 1988; 79: 556
   PubMedGoogle Scholar
• Sato K. Glutathione transferases as markers of preneoplasia and neoplasia. Adv. Cancer Res. 1989; 52: 205
   PubMed Web of Science ®Google Scholar
• Moscow J. A., Cowan K. H. Multidrug resistance. J. Natl. Cancer Inst. 1988; 80: 14
   PubMed Web of Science ®Google Scholar
• Tew K. D. The involvement of glutathione S-transferases in drug resistance. Anticancer Drugs 1989; 191: 103
   Google Scholar
• Mannervik B., Danielson U. H. Glutathione transferases — structure and catalytic activity. CRC Crit. Rev. Biochem. Mol. Biol. 1988; 23: 283
   Web of Science ®Google Scholar
• Guthenberg C., Mannervik B. Purification of glutathione S-transferases from rat lung by affinity chromatography. Evidence for an enzyme form absent in rat liver. Biochem. Biophys. Res. Commun. 1979; 86: 1304
   PubMed Web of Science ®Google Scholar
• Simons P. C., Vander Jagt D. L. Purification of glutathione S-transferases from human liver by glutathione-affinity chromatography. Anal. Biochem. 1977; 82: 334
   PubMed Web of Science ®Google Scholar
• Mannervik B., Jensson H. Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol. J. Biol. Chem. 1982; 257: 9909
   PubMed Web of Science ®Google Scholar
• Sato K., Tsuchida S. Glutathione transferases in normal, preneoplastic, and neoplastic tissues: forms and functions. Biochemical and Molecular Aspects of Selected Cancers, T. G. Pretlow, II, T. P. Pretlow. Academic Press, San Diego 1991; Vol. 1: 177
   Google Scholar
• Mannervik B., Ålin P., Guthenberg C., Jensson H., Tahir M. K., Warholm M., Jörnvall H. Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proc. Natl. Acad. Sci. U.S.A. 1985; 82: 7202
   PubMed Web of Science ®Google Scholar
• Meyer D. J., Coles B., Pemble S. E., Gilmore K. S., Fraser G. M., Ketterer B. Theta, a new class of glutathione transferases purified from rat and man. Biochem. J. 1991; 274: 409
   PubMed Web of Science ®Google Scholar
• Hiratsuka A., Sebata N., Kawashima K., Okuda H., Ogura K., Watabe T., Satoh K., Hatayama I., Tsuchida S., Ishikawa T., Sato K. A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabolites of carcinogenic arylmethanols. J. Biol. Chem. 1990; 265: 11973
   PubMed Web of Science ®Google Scholar
• Ding G. J.-F., Lu A. Y. H., Pickett C. B. Rat liver glutathione S-transferases. Nucleotide sequence analysis of a Yb1 cDNA clone and prediction of the complete amino acid sequence of the Yb1 sub-unit. J. Biol. Chem. 1985; 260: 13268
   PubMed Web of Science ®Google Scholar
• Lai H.-C. J., Grove G., Tu C.-P. D. Cloning and sequence analysis of a cDNA for a rat liver glutathione S-transferase Yb subunit. Nucleic Acids Res. 1986; 14: 6101
   PubMed Web of Science ®Google Scholar
• Chang C., Saltzman A. G., Sorensen N. S., Hiipakka R. A., Liao S. Identification of glutathione S-transferase Yb1 mRNA as the androgen-repressed mRNA by cDNA cloning and sequence analysis. J. Biol. Chem. 1987; 262: 11901
   PubMed Web of Science ®Google Scholar
• Lai H.-C. J., Qian B., Tu C.-P. D. Characterization of a variant rat glutathione S-transferase by cDNA expression i. Escherichia coli, Arch. Biochem. Biophys. 1989; 273: 423
   PubMed Web of Science ®Google Scholar
• Kano T., Sakai M., Muramatsu M. Structure and expression of a human class glutathione S-transferase messenger RNA. Cancer Res. 1987; 47: 5626
   PubMed Web of Science ®Google Scholar
• Moscow J. A., Fairchild C. R., Madden M. J., Ransom D. T., Wieand H. S., O'Brien E. E., Poplack D. G., Cossman J., Myers C. E., Cowan K. H. Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tis-I sues and tumors. Cancer Res. 1989; 49: 1422
   PubMed Web of Science ®Google Scholar
• Wang Y., Teicher B. A., Shea T. C., Holden S. A., Rosbe K. W., Al-Achi A., Henner W. D. Cross-resistance and glutathione-S-transferase levels among four human melanoma cell lines selected for alkylating agent resistance. Cancer Res. 1989; 49: 6185
   PubMed Web of Science ®Google Scholar
• Tu C.-P. D., Qian B. Human liver glutathione S-transferases: complete primary sequence of an Ha subunit cDNA. Biochem. Biophys. Res. Commun. 1986; 141: 229
   PubMed Web of Science ®Google Scholar
• Board P. G., Webb G. C. Isolation of acDNA clone and localization of human glutathione S-transferase 2 genes to chromosome band 6p12. Proc. Natl. Acad. Sci. U.S.A. 1987; 84: 2377
   PubMed Web of Science ®Google Scholar
• Klöne A., Weidner U., Hußnätter R., Harris J., Meyer D., Peter S., Ketterer B., Sies H. Decreased expression of the glutathione S-transferases alpha and pi genes in human renal cell carcinoma. Carcinogenesis (London) 1990; 11: 2179
   PubMed Web of Science ®Google Scholar
• Pearson W. R., Reinhart J., Sisk S. C., Anderson K. S., Adler P. N. Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole. J. Biol. Chem. 1988; 263: 13324
   PubMed Web of Science ®Google Scholar
• Townsend A. J., Goldsmith M. E., Pickett C. B., Cowan K. H. Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2). J. Biol. Chem. 1989; 264: 21582
   PubMed Web of Science ®Google Scholar
• Morgenstern R., DePierre J. W. Membrane-bound glutathione transferases. Glutathione Conjugation, H. Sies, B. Ketterer. Academic Press, London 1988; 157
   Google Scholar
• Jakoby W. B., Ketterer B., Mannervik B. Glutathione transferases: nomenclature. Biochem. Pharmacol. 1984; 33: 2539
   PubMed Web of Science ®Google Scholar
• Ishikawa T., Tsuchida S., Satoh K., Sato K. The subunit structure of a major glutathione S-transferase form (MT) in rat testis: evidence for a heterodimer consisting of subunits with different isoelectric points. Eur. J. Biochem. 1988; 176: 551
   PubMedGoogle Scholar
• Tsuchida S., Izumi T., Shimizu T., Ishikawa T., Hatayama I., Satoh K., Sato K. Purification of a new acidic glutathione S-transferase, GST-Yn1Yn1, with a high leukotriene-C4 synthase activity from rat brain. Eur. J. Biochem. 1987; 170: 159
   PubMedGoogle Scholar
• Abramovitz M., Listowsky I. Selective expression of a unique glutathione S-transferase Yb3 gene in rat brain. J. Biol. Chem. 1987; 262: 7770
   PubMed Web of Science ®Google Scholar
• Abramovitz M., Ishigaki S., Felix A. M., Listowsky I. Expression of an enzymatically active Yb3 glutathione S-transferase in Escherichia coli and identification of its natural form in rat brain. J. Biol. Chem. 1988; 263: 17627
   PubMed Web of Science ®Google Scholar
• Pickett C. B., Telakowski-Hopkins C. A., Ding G. J.-F., Algenbright L., Lu A. Y. H. Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb and Yc mRNAs by 3-methylcholanthrene and phenobarbital. J. Biol. Chem. 1984; 259: 5182
   PubMed Web of Science ®Google Scholar
• Lai H.-C. J., Li N.-Q., Weiss M. J., Reddy C. C., Tu C.-P. D. The nucleotide sequence of a rat liver glutathione S-transferase subunit cDNA clone. J. Biol. Chem. 1984; 259: 5536
   PubMed Web of Science ®Google Scholar
• Telakowski-Hopkins C. A., Rodkey J. A., Bennett C. D., Lu A. Y. H., Pickett C. B. Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit. J. Biol. Chem. 1985; 260: 5820
   PubMed Web of Science ®Google Scholar
• Lai H.-C. J., Tu C.-P. D. Rat glutathione S-transferases supergene family. Characterization of an anionic Yb subunit cDNA clone. J. Biol. Chem. 1986; 261: 13793
   PubMed Web of Science ®Google Scholar
• Ding G. J.-F., Ding V. D.-H., Rodkey J. A., Bennett C. D., Lu A. Y. H., Pickett C. B. Rat liver glutathione S-transferases. DNA sequence analysis of a Yb2 cDNA clone and regulation of the Yb1 and Yb2 mRNAs by phenobarbital. J. Biol. Chem. 1986; 261: 7952
   PubMed Web of Science ®Google Scholar
• Suguoka Y., Kano T., Okuda A., Sakai M., Kitagawa T., Muramatsu M. Cloning and the nucleotide sequence of rat glutathione S-transferase PcDNA. Nucleic Acids Res. 1985; 13: 6049
   PubMed Web of Science ®Google Scholar
• Pemble S. E., Taylor J. B., Ketterer B. Tissue distribution of rat glutathione transferase sub-unit 7, a hepatoma marker. Biochem. J. 1986; 240: 885
   PubMed Web of Science ®Google Scholar
• Telakowski-Hopkins C. A., Rothkopf G. S., Pickett C. B. Structural analysis of a rat liver glutathione S-transferase Ya gene. Proc. Natl. Acad. Sci. U.S.A. 1986; 83: 9393
   PubMed Web of Science ®Google Scholar
• Morton M. R., Bayney R. M., Pickett C. B. Isolation and characterization of the rat glutathione S-transferase Yb1 subunit gene. Arch. Biochem. Biophys. 1990; 277: 56
   PubMed Web of Science ®Google Scholar
• Lai H.-C. J., Qian B., Grove G., Tu C.-P. D. Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family. J. Biol. Chem. 1988; 263: 11389
   PubMed Web of Science ®Google Scholar
• Okuda A., Sakai M., Muramatsu M. The structure of the rat glutathione S-transferase P gene and related pseudogenes. J. Biol. Chem. 1987; 262: 3858
   PubMed Web of Science ®Google Scholar
• Sakai M., Okuda A., Muramatsu M. Multiple regulatory elements and phorbol 12-O-tetradecanoate 13-acetate responsiveness of the rat placental glutathione transferase gene. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 9456
   PubMed Web of Science ®Google Scholar
• Wang R. W., Pickett C. B., Lu A. Y. H. Expression of a cDNA encoding a rat liver glutathione S-transferase Ya subunit i. Escherichia coli, Arch. Biochem. Biophys. 1989; 269: 536
   PubMed Web of Science ®Google Scholar
• Huskey S.-E. W., Wang R. W., Linemeyer D. L., Pickett C. B., Lu A. Y. H. Expression in Escherichia coli of rat liver cytosolic glutathione S-transferase Yc cDNA. Arch. Biochem. Biophys. 1990; 279: 116
   PubMed Web of Science ®Google Scholar
• Hsieh J.-C., Liu L.-F., Chen W.-L., Tam M. F. Expression of Yb1 glutathione S-transferase using a baculovirus expression system. Biochem. Biophys. Res. Commun. 1989; 162: 1147
   PubMed Web of Science ®Google Scholar
• Dejong J. L., Morgenstern R., Jörnvall H., De Pierre J. W., Tu C.-P. D. Gene expression of rat and human microsomal glutathione S-transferases. J. Biol. Chem. 1988; 263: 8430
   PubMed Web of Science ®Google Scholar
• Hayes J. D., Kerr L. A., Harrison D. J., Cronshaw A. D., Ross A. G., Neals G. E. Preferential over-expression of the class alpha rat Ya2 glutathione S-transferase subunit in livers bearing aflatoxin-induced pre-neoplastic nodules. Comparison of the primary structures of Ya1 and Ya2 with cloned class alpha glutathione S-transferase cDNA sequences. Biochem. J. 1990; 268: 295
   PubMed Web of Science ®Google Scholar
• Telakowski-Hopkins C. A., King R. G., Pickett C. B. Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 1000
   PubMed Web of Science ®Google Scholar
• Rothkopf G. S., Telakowski-Hopkins C. A., Stotish R. L., Pickett C. B. Multiplicity of glutathione S-transferase genes in the rat and association with a type 2 Alu repetitive element. Biochemistry 1986; 25: 993
   PubMed Web of Science ®Google Scholar
• Rushmore T. H., King R. G., Paulson K. E., Pickett C. B. Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 3826
   PubMed Web of Science ®Google Scholar
• Rushmore T. H., Pickett C. B. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. J. Biol. Chem. 1990; 265: 14648
   PubMed Web of Science ®Google Scholar
• Okuda A., Imagawa M., Sakai M., Muramatsu M. Functional cooperativity between two TPA responsive elements in undifferentiated F9 embryonic stem cells. EMBO J. 1990; 9: 1131
   PubMed Web of Science ®Google Scholar
• Paulson K. E., Darnell J. E., Jr., Rushmore T., Pickett C. B. Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene. Mol. Cell. Biol. 1990; 10: 1841
   PubMed Web of Science ®Google Scholar
• Kispert A., Meyer D. J., Lalor E., Coles B., Ketterer B. Purification and characterization of a labile rat glutathione transferase of the Mu class. Biochem. J. 1989; 260: 789
   PubMed Web of Science ®Google Scholar
• Yoshimoto T., Soberman R. J., Lewis R. A., Austen K. F. Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells. Proc. Natl. Acad. Sci. U.S.A. 1985; 82: 8399
   PubMed Web of Science ®Google Scholar
• Urade Y., Fujimoto N., Ujihara M., Hayaishi O. Biochemical and immunological characterization of rat spleen prostaglandin D synthetase. J. Biol. Chem. 1987; 262: 3820
   PubMed Web of Science ®Google Scholar
• Taniguchi H., Pyerin W. Glutathione S-transferase is an in vitro substrate of Ca++-phospholipid-dependent protein kinase (protein kinase C). Biochem. Biophys. Res. Commun. 1989; 162: 903
   PubMed Web of Science ®Google Scholar
• Johnson J. A., Neal T. L., Collins J. H., Siegel F. L. Characterization of methylation of rat liver cytosolic glutathione S-transferases by using reverse-phase h.p.1.c. and chromatofocusing. Biochem. J. 1990; 270: 483
   PubMed Web of Science ®Google Scholar
• Kuzmich S., Vanderveer L. A., Tew K. D. Evidence for a glycoconjugate form of glutathione S-transferase pi. Int. J. Pep. Protein Res. 1991; 37: 565
   PubMedGoogle Scholar
• Hayes J. D., Mantle T. J. Use of immunoblot techniques to discriminate between the glutathione S-transferase Yf, Yk, Ya, Yn/Yb and Yc subunits and to study their distribution in extrahepatic tissues. Biochem. J. 1986; 233: 779
   PubMed Web of Science ®Google Scholar
• Tu C.-P. D., Qian B. Nucleotide sequence of the human liver glutathione S-transferase subunit 1 cDNA. Biochem. Soc. Trans. 1987; 15: 734
   PubMed Web of Science ®Google Scholar
• Tatematsu M., Mera Y., Ito N., Satoh K., Sato K. Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis (London) 1985; 6: 1621
   PubMed Web of Science ®Google Scholar
• McCusker F. M. G., Boyce S. J., Mantle T. J. The development of glutathione S-transferase subunits in rat liver. Sensitive detection of the major subunit forms of rat glutathione S-transferase by using an e.1.i.s.a. method. Biochem. J. 1989; 262: 463
   PubMed Web of Science ®Google Scholar
• Scott T. R., Kirsch R. E. The isolation of a fetal rat liver glutathione S-transferase isoenzyme with high glutathione peroxidase activity. Biochim. Biophys. Acta 1987; 926: 264
   PubMedGoogle Scholar
• Meyer D. J., Gilmore K. S., Coles B., Dalton K., Hulbert P. B., Ketterer B. Structural distinction of rat GSH transferase subunit 10. Biochem. J. 1991; 274: 619
   PubMed Web of Science ®Google Scholar
• Igarashi T., Satoh T., Iwashita K., Ono S., Ueno K., Kitagawa H. Sex difference in subunit composition of hepatic glutathione S-transferase in rats. J. Biochem. (Tokyo) 1985; 98: 117
   PubMed Web of Science ®Google Scholar
• Igarashi T., Satoh T. Sex and species differences in glutathione S-transferase activities. Drug Metab. Drug Interact. 1989; 7: 191
   PubMedGoogle Scholar
• Li N.-Q., Tu C.-P. D. Suppression of glutathione S-transferases in rat seminal vesicles or pituitary glands. Biochem. Biophys. Res. Commun. 1986; 136: 1057
   PubMed Web of Science ®Google Scholar
• Mankowitz L., Castro V. M., Mannervik B., Rydström J., DePierre J. W. Increase in the amount of glutathione transferase 4-4 in the rat adrenal gland after hypophysectomy and down-regulation by subsequent treatment with adrenocorticotrophic hormone. Biochem. J. 1990; 265: 147
   PubMed Web of Science ®Google Scholar
• Listowsky I., Campbell E., Takahashi Y., Ishigaki S., Abramovitz M., Homma H. Extrahepatic glutafhione-S-transferases: binding and hormonal regulation. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, T. J. Mantle. Taylor & Francis, London 1990; 272
   Google Scholar
• Vandenberghe Y., Glaise D., Meyer D. J., Guillouzo A., Ketterer B. Glutathione transferase isoenzymes in cultured rat hepatocytes. Biochem. Pharmacol. 1988; 37: 2482
   PubMed Web of Science ®Google Scholar
• Vandenberghe Y., Foriers A., Rogiers V., Vercruysse A. Changes in expression and “de novo” synthesis of glutathione S-transferase subunits in cultured adult rat hepatocytes. Biochem. Pharmacol. 1990; 39: 685
   PubMed Web of Science ®Google Scholar
• Vandenberghe Y., Morel F., Pemble S., Taylor J. B., Rogiers V., Ratanasavanh D., Vercruysse A., Ketterer B., Guillouzo A. Changes in expression of mRNA coding for glutathione S-transferase subunits 1-2 and 7 in cultured rat hepatocytes. Mol. Pharmacol. 1990; 37: 372
   PubMed Web of Science ®Google Scholar
• Morel F., Vandenberghe Y., Pemble S., Taylor J. B., Ratanasavanh D., Rogiers V., Ketterer B., Guillouzo A. Regulation of glutathione S-transferase subunits 3 and 4 in cultured rat hepatocytes. FEBS Lett. 1989; 258: 99
   PubMed Web of Science ®Google Scholar
• Hatayama I., Yamada Y., Tanaka K., Ichihara A., Sato K. Induction of glutathione S-transferase P-form in primary cultured rat hepatocytes by epidermal growth factor and insulin. Jpn. J. Cancer Res. 1991; 82: 807
   PubMedGoogle Scholar
• Abramovitz M., Ishigaki S., Listowsky I. Differential regulation of glutathione-S-transferases in cultured hepatocytes. Hepatology 1989; 9: 235
   PubMed Web of Science ®Google Scholar
• Senjo M., Ishibashi T. Possible involvement of glutathione S-transferases in the cell growth of C6 astroglioma cells. J. Neurochem. 1988; 50: 163
   PubMed Web of Science ®Google Scholar
• Sato Y., Fujii S., Fujii Y., Kaneko T. Antiproliferative effects of glutathione S-transferase inhibitors on the K562 cell line. Biochem. Pharmacol. 1990; 39: 1263
   PubMed Web of Science ®Google Scholar
• Tew K. D., Bomber A. M., Hoffman S. J. Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines. Cancer Res. 1988; 48: 3622
   PubMed Web of Science ®Google Scholar
• Clapper M. L., Hoffman S. J., Tew K. D. Sensitization of human colon tumor xenografts to l-phenylalanine mustard using ethacrynic acid. J. Cell Pharmacol. 1990; 1: 71
   Google Scholar
• Hansson J., Berhane K., Castro V. M., Jungnelius U., Mannervik B., Ringborg U. Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid. Cancer Res. 1991; 51: 94
   PubMed Web of Science ®Google Scholar
• Hall A., Robson C. N., Hickson I. D., Harris A. L., Proctor S. J., Cattan A. R. Possible role of inhibition of glutathione S-transferase in the partial reversal of chlorambucil resistance by indomethacin in a Chinese hamster ovary cell line. Cancer Res. 1989; 49: 6265
   PubMed Web of Science ®Google Scholar
• Igwe O. J. Biologically active intermediates generated by the reduced glutathione conjugation pathway. Toxicological implications. Biochem. Pharmacol. 1986; 35: 2987
   PubMed Web of Science ®Google Scholar
• Booth J., Boyland E., Sims P. An enzyme from rat liver catalysing conjugations with glutathione. Biochem. J. 1961; 79: 516
   PubMed Web of Science ®Google Scholar
• Kitahara A., Yamazaki I., Ishikawa T., Camba E. A., Sato K. Changes in activities of glutathione peroxidase and glutathione reductase during chemical hepatocarcinogenesis in the rat. Gann 1983; 74: 649
   PubMedGoogle Scholar
• Meyer D. J., Beale D., Tan K. H., Coles B., Ketterer B. Glutathione transferases in primary rat hepatomas: the isolation of a form with GSH peroxidase activity. FEBS Lett. 1985; 184: 139
   PubMed Web of Science ®Google Scholar
• Tan K. H., Meyer D. J., Gillies N., Ketterer B. Detoxification of DNA hydroperoxide by glutathione transferases and the purification and characterization of glutathione transferases of the rat liver nucleus. Biochem. J. 1988; 254: 841
   PubMed Web of Science ®Google Scholar
• Ketterer B., Tan K. H., Meyer D. J., Coles B. Glutathione transferases: a possible role in the detoxication of DNA and lipid hydroperoxides. Glutathione S-transferases and Carcinogenesis, T. J. Mantle, C. B. Pickett, J. D. Hayes. Taylor & Francis, London 1987; 149
   Google Scholar
• Ketterer B., Taylor J. B., Meyer D. J., Coles B., Pemble S., Cowell I. G., Dixon K. Glutathione S-transferases: structure and function. Glutathione Centennial Molecular Perspectives and Clinical Implications, N. Taniguchi, T. Higashi, Y. Sakamoto, A. Meister. Academic Press, London 1989; 241
   Google Scholar
• Jensson H., Guthenberg C., Ålin P., Mannervik B. Rat glutathione transferase 8-8, an enzyme efficiently detoxifying 4-hydroxyalk-2-enals. FEBS Lett. 1986; 203: 207
   PubMed Web of Science ®Google Scholar
• Daniel V., Sharon R., Tichauer Y., Sarid S. Mouse glutathione S-transferase Ya subunit: gene structure and sequence. DNA 1987; 6: 317
   PubMedGoogle Scholar
• Chang M., Hong Y., Burgess J. R., Tu C.-P. D., Reddy C. C. Isoenzyme specificity of rat liver glutathione S-transferases in the formation of PGF2α, and PGE2 from PGH2. Arch. Biochem. Biophys. 1987; 259: 548
   PubMed Web of Science ®Google Scholar
• Ujihara M., Tsuchida S., Satoh K., Sato K., Urade Y. Biochemical and Immunological demonstration of prostaglandin D2, E2, and F2α formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. Arch. Biochem. Biophys. 1988; 264: 428
   PubMed Web of Science ®Google Scholar
• Laneuville O., Chang M., Reddy C. C., Corey E. J., Pace-Asciak C. R. Isozyme specificity in the conversion of hepoxilin A3 (HxA3) into a glu-tathionyl hepoxilin (HxA3-C) by the Yb2 subunit of rat liver glutathione S-transferase. J. Biol. Chem. 1990; 265: 21415
   PubMed Web of Science ®Google Scholar
• Benson A. M., Talalay P., Keen J. H., Jakoby W. B. Relationship between the soluble glutathione-dependent Δ5-3-ketosteroid isomerase and the glutathione S-transferases of the liver. Proc. Natl. Acad. Sci. U.S.A. 1977; 74: 158
   PubMed Web of Science ®Google Scholar
• Maruyama H., Listowsky I. Preferential binding of steroids by anionic forms of rat glutathione S-transferase. J. Biol. Chem. 1984; 259: 12449
   PubMed Web of Science ®Google Scholar
• Homma H., Maruyama H., Niitsu Y., Listowsky I. A subclass of glutathione S-transferases as intracellular high-capacity and high-affinity steroid-binding proteins. Biochem. J. 1986; 235: 763
   PubMed Web of Science ®Google Scholar
• Ishigaki S., Abramovitz M., Listowsky I. Glutathione-S-transferases are major cytosolic thyroid hormone binding proteins. Arch. Biochem. Biophys. 1989; 273: 265
   PubMed Web of Science ®Google Scholar
• Senjo M., Ishibashi T., Imai Y. Purification and characterization of cytosolic liver protein facilitating heme transport into apocytochrome b5 from mitochondria. Evidence for identifying the heme transfer protein as belonging to a group of glutathione S-transferases. J. Biol. Chem. 1985; 260: 9191
   PubMed Web of Science ®Google Scholar
• Sun F. F., Chau L.-Y., Spur B., Corey E. J., Lewis R. A., Austen K. F. Identification of a high affinity leukotriene C4-binding protein in rat liver cytosol as glutathione S-transferase. J. Biol. Chem. 1986; 261: 8540
   PubMed Web of Science ®Google Scholar
• Falk E., Müller M., Huber M., Keppler D., Kurz G. Direct photoaffinity labeling of leukotriene binding sites. Eur. J. Biochem. 1989; 186: 741
   PubMedGoogle Scholar
• Smith G. J., Litwack G. Roles of ligandin and the glutathione S-transferases in binding steroid metabolites, carcinogens and other compounds. Rev. Biochem. Toxicol 1980; 2: 1
   Google Scholar
• Listowsky I., Abramovitz M., Homma H., Niitsu Y. Intracellular binding and transport of hormones and xenobiotics by glutathione-S-transferases. Drug Metab. Rev. 1988; 19: 305
   PubMed Web of Science ®Google Scholar
• Adang A. E. P., Brussee J., Meyer D. J., Coles B., Ketterer B., Van Der Gen A., Mulder G. J. Substrate specificity of rat liver glutathione S-transferase isoenzymes for a series of glutathione analogues, modified at the γ-glutamyl moiety. Biochem. J. 1988; 255: 721
   PubMed Web of Science ®Google Scholar
• Adang A. E. P., Meyer D. J., Brussee J., Van Der Gen A., Ketterer B., Mulder G. J. Interaction of rat glutathione S-transferases 7-7 and 8-8 with glutamyl- or glycyl-modified glutathione analogues. Biochem. J. 1989; 264: 759
   PubMed Web of Science ®Google Scholar
• Ketley J. N., Habig W. H., Jakoby W. B. Binding of nonsubstrate ligands to the glutathione S-transferases. J. Biol. Chem. 1975; 250: 8670
   PubMed Web of Science ®Google Scholar
• Vander Jagt D. L., Wilson S. P., Dean V. L., Simons P. C. Bilirubin binding to rat liver ligandins (glutathione S-transferases A and B). Relationship between bilirubin binding and transferase activity. J. Biol. Chem. 1982; 257: 1997
   PubMed Web of Science ®Google Scholar
• Boyer T. D., Vessey D. A. Inhibition of human cationic glutathione S-transferase by nonsubstrate ligands. Hepatology 1987; 7: 843
   PubMed Web of Science ®Google Scholar
• Hayes J. D., Mantle T. J. Inhibition of hepatic extrahepatic glutathione S-transferases by primary and secondary bile acids. Biochem. J. 1986; 233: 407
   PubMed Web of Science ®Google Scholar
• Takikawa H., Kaplowitz N. Comparison of the binding sites of GSH S-transferases of the Ya-and Yb-subunit classes: effect of glutathione on the binding of bile acids. J. Lipid Res. 1988; 29: 279
   PubMed Web of Science ®Google Scholar
• Satoh K., Hatayama I., Tsuchida S., Sato K. Biochemical characteristics of a preneoplastic marker enzyme glutathione S-transferase P-form (7-7). Arch. Biochem. Biophys. 1991; 285: 312
   PubMed Web of Science ®Google Scholar
• Van Ommen B., Den Besten C., Rutten A. L. M., Ploemen J. H. T. M., Vos R. M. E., Müller F., Van Bladeren P. J. Active site-directed irreversible inhibition of glutathione S-transferases by the glutathione conjugate of tetrachloro-1,4-benzoquinone. J. Biol. Chem. 1988; 263: 12939
   PubMed Web of Science ®Google Scholar
• Van Ommen B., Ploemen J. H. T.M., Ruven H. J., Vos R. M. E., Bogaards J. J. P., Van Berkel W. J. H., Van Bladeren P. J. Studies on the active site of rat glutathione S-transferase isoenzyme 4-4. Chemical modification by tetrachloro-1,4-benzoquinone and its glutathione conjugate. Eur. J. Biochem. 1989; 181: 423
   PubMedGoogle Scholar
• Schäffer J., Gailay O., Ladenstein R. Glutathione transferase from bovine placenta. Preparation, biochemical characterization, crystallization, and preliminary crystallographic analysis of a neutral class pi enzyme. J. Biol. Chem. 1988; 263: 17405
   PubMed Web of Science ®Google Scholar
• Ricci G., Del Boccio G., Pennelli A., Aceto A., Whitehead E. P., Federici G. Nonequivalence of the two subunits of horse erythrocyte glutathione transferase in their reaction with sulfhydryl reagents. J. Biol. Chem. 1989; 264: 5462
   PubMed Web of Science ®Google Scholar
• Graminski G. F., Kubo Y., Armstrong R. N. Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione S-transferase. Biochemistry 1989; 28: 3562
   PubMed Web of Science ®Google Scholar
• Graminski G. F., Zhang P., Sesay M. A., Ammon H. L., Armstrong R. N. Formation of the 1-(S-glutathionyl)-2,4,6-trinitrocyclohexadienate anion at the active site of glutathione S-transferase: evidence for enzymic stabilization of complex intermediates in nucleophilic aromatic substitution reactions. Biochemistry 1989; 28: 6252
   PubMed Web of Science ®Google Scholar
• Stenberg G., Board P. G., Carlberg I., Mannervik B. Effects of directed mutagenesis on conserved arginine residues in a human class alpha glutathione transferase. Biochem. J. 1991; 274: 549
   PubMed Web of Science ®Google Scholar
• Wang R. W., Newton D. J., Pickett C. B., Lu A. Y. H. Site-directed mutagenesis of glutathione S-transferase YaYa: nonessential role of his-tidine in catalysis. Arch. Biochem. Biophys. 1991; 286: 574
   PubMed Web of Science ®Google Scholar
• Hoesch R. M., Boyer T. D. Localization of a portion of the active site of two rat liver glutathione S-transferases using a photoaffinity label. J. Biol. Chem. 1989; 264: 17712
   PubMed Web of Science ®Google Scholar
• Board P. G., Mannervik B. The contribution of the C-terminal sequence to the catalytic activity of GST 2, a human alpha-class glutathione transferase. Biochem. J. 1991; 275: 171
   PubMed Web of Science ®Google Scholar
• Zhang P., Armstrong R. N. Construction, expression, and preliminary characterization of chimeric class μ glutathione S-transferases with altered catalytic properties. Biopolymers 1990; 29: 159
   PubMed Web of Science ®Google Scholar
• Tamai K., Satoh K., Tsuchida S., Hatayama I., Maki T., Sato K. Specific inactivation of glutathione S-transferases in class pi by SH-modifiers. Biochem. Biophys. Res. Commun. 1990; 167: 331
   PubMed Web of Science ®Google Scholar
• Shen H., Tamai K., Satoh K., Hatayama I., Tsuchida S., Sato K. Modulation of class pi glutathione transferase activity by sulfhydryl group modification. Arch. Biochem. Biophys. 1991; 286: 178
   PubMed Web of Science ®Google Scholar
• Nishihara T., Maeda H., Okamoto K., Oshida T., Mizoguchi T., Terada T. Inactivation of human placenta glutathione S-transferase by SH/SS exchange reaction with biological disulfides. Biochem. Biophys. Res. Commun. 1991; 174: 580
   PubMed Web of Science ®Google Scholar
• Dirr H. W., Mann K., Huber R., Ladenstein R., Reinemer P. Class glutathione S-transferase from pig lung. Purification, biochemical characterization, primary structure and crystallization. Eur. J. Biochem. 1991; 196: 693
   PubMedGoogle Scholar
• Desideri A., Caccuri A. M., Polizio F., Bastoni R., Federici G. Electron paramagnetic resonance identification of a highly reactive thiol group in the proximity of the catalytic site of human placenta glutathione transferase. J. Biol. Chem. 1991; 266: 2063
   PubMed Web of Science ®Google Scholar
• Murata T., Hatayama I., Satoh K., Tsuchida S., Sato K. Activation of rat glutathione transferases in class mu by active oxygen species. Biochem. Biophys. Res. Commun. 1990; 171: 845
   PubMed Web of Science ®Google Scholar
• Tamai K., Shen H., Tsuchida S., Hatayama I., Satoh K., Yasui A., Oikawa A., Sato K. Role of cysteine residues in the activity of rat glutathione transferase P (7-7): elucidation by oligonucleotide site-directed mutagenesis. Biochem. Biophys. Res. Commun. 1991; 179: 790
   PubMed Web of Science ®Google Scholar
• Adang A. E. P., Brussee J., Van der Gen A., Mulder G. M. Inhibition of rat liver glutathione S-transferase isoenzymes by peptides stabilized against degradation by γ-glutamyl transpeptidase. J. Biol. Chem. 1991; 266: 830
   PubMed Web of Science ®Google Scholar
• Mannervik B., Awasthi Y. C., Board P. G., Hayes J. D., Di Ilio C., Ketterer B., Listowsky I., Morgenstern R., Muramatsu M., Pearson W. R., Pickett C. B., Sato K., Widersten M., Wolf C. R. Nomenclature for human glutathione transferases. Biochem. J. 1992; 282: 305
   PubMed Web of Science ®Google Scholar
• Board P., Coggan M., Johnston P., Ross V., Suzuki T., Webb G. Genetic heterogeneity of the human glutathione transferases: a complex of gene families. Pharmacol. Ther. 1990; 48: 357
   PubMed Web of Science ®Google Scholar
• Kamisaka K., Habig W. H., Ketley J. N., Arias I. M., Jakoby W. B. Multiple forms of human glutathione S-transferase and their affinity for bilirubin. Eur. J. Biochem. 1975; 60: 153
   PubMedGoogle Scholar
• Stockman P. K., Beckett G. J., Hayes J. D. Identification of a basic hybrid glutathione S-transferase from human liver. Glutathione S-transferase δ is composed of two distinct subunits (B1 and B2). Biochem. J. 1985; 227: 457
   PubMed Web of Science ®Google Scholar
• Soma Y., Satoh K., Sato K. Purification and subunit-structural and immunological characterization of five glutathione S-transferases in human liver, and the acidic form as a hepatic tumor marker. Biochim. Biophys. Acta 1986; 869: 247
   PubMed Web of Science ®Google Scholar
• Del Boccio G., Di Ilio C., Ålin P., Jörnvall H., Mannervik B. Identification of a novel glutathione transferase in human skin homologous with class alpha glutathione transferase 2-2 in the rat. Biochem. J. 1987; 244: 21
   PubMed Web of Science ®Google Scholar
• Singhal S. S., Gupta S., Ahmad H., Sharma R., Awasthi Y. C. Characterization of a novel α-class anionic glutathione S-transferase isozyme from human liver. Arch. Biochem. Biophys. 1990; 279: 45
   PubMed Web of Science ®Google Scholar
• Chow N.-W. I., Whang-Peng J., Kao-Shan C.-S., Tarn M. F., Lai H.-C. J., Tu C.-P. D. Human glutathione S-transferases. The Ha multigene family encodes products of different but overlapping substrate specificities. J. Biol. Chem. 1988; 263: 12797
   PubMed Web of Science ®Google Scholar
• Stockman P. K., McLellan L. I., Hayes J. D. Characterization of the basic glutathione S-transferase B1 and B2 subunits from human liver. Biochem. J. 1987; 244: 55
   PubMed Web of Science ®Google Scholar
• Lewis A. D., Hickson I. D., Robson C. N., Harris A. L., Hayes J. D., Griffiths S. A., Manson M. M., Hall A. E., Moss J. E., Wolf C. R. Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 8511
   PubMed Web of Science ®Google Scholar
• Warholm M., Guthenberg C., Mannervik B., von Bahr C. Purification of a new glutathione S-transferase (transferase μ) from human liver having high activity with benzo(α)pyrene-4,5-oxide. Biochem. Biophys. Res. Commun. 1981; 98: 512
   PubMed Web of Science ®Google Scholar
• Warholm M., Guthenberg C., Mannervik B. Molecular and catalytic properties of glutathione transferase μ from human liver: an enzyme efficiently conjugating epoxides. Biochemistry 1983; 22: 3610
   PubMed Web of Science ®Google Scholar
• Awasthi Y. C., Dao D. D., Saneto R. P. Interrelationship between anionic and cationic forms of glutathione S-transferases of human liver. Biochem. J. 1980; 191: 1
   PubMed Web of Science ®Google Scholar
• Singh S. V., Kurosky A., Awasthi Y. C. Human liver glutathione S-transferase PS. Chemical characterization and secondary-structure comparison with other mammalian glutathione S-transferases. Biochem.J. 1987; 243: 61
   PubMed Web of Science ®Google Scholar
• Board P. G. Biochemical genetics of glutathione S-transferase in man. Am. J. Hum. Genet. 1981; 33: 36
   PubMed Web of Science ®Google Scholar
• DeJong J. L., Chang C.-M., Whang-Peng J., Knutsen T., Tu C.-P. D. The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA. Nucleic Acids Res. 1988; 16: 8541
   PubMed Web of Science ®Google Scholar
• Seidegård J., Vorachek W. R., Pero R. W., Pearson W. R. Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 7293
   PubMed Web of Science ®Google Scholar
• Widersten M., Pearson W. R., Engström Å., Mannervik B. Heterologous expression of the allelic variant class mu glutathione transferases μ and PS. Biochem. J. 1991; 276: 519
   PubMed Web of Science ®Google Scholar
• Laisney V., Cong N. V., Gross M. S., Frezal J. Human genes for glutathione S-transferases. Hum. Genet. 1984; 68: 221
   PubMed Web of Science ®Google Scholar
• Board P. G., Suzuki T., Shaw D. C. Human muscle glutathione S-transferase (GST-4) shows close homology to human liver GST-1. Biochim. Biophys. Acta 1988; 953: 214
   PubMed Web of Science ®Google Scholar
• Singh S. V., Ahmad H., Kurosky A., Awasthi Y. C. Purification and characterization of unique glutathione S-transferases from human muscle. Arch. Biochem. Biophys. 1988; 264: 13
   PubMed Web of Science ®Google Scholar
• Singhal S. S., Ahmad H., Sharma R., Gupta S., Haque A. K., Awasthi Y. C. Purification and characterization of human muscle glutathione S-transferases: evidence that glutathione S-transferase °Corresponds to a locus distinct from GST1, GST2, and GST3. Arch. Biochem. Biophys. 1991; 285: 64
   PubMed Web of Science ®Google Scholar
• Tsuchida S., Maki T., Sato K. Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class mu forms. J. Biol. Chem. 1990; 265: 7150
   PubMed Web of Science ®Google Scholar
• Hussey A. J., Kerr L. A., Cronshaw A. D., Harrison D. J., Hayes J. D. Variation in the expression of mu-class glutathione S-transferase isoenzymes from human skeletal muscle. Evidence for the existence of heterodimers. Biochem. J. 1991; 273: 323
   PubMed Web of Science ®Google Scholar
• Vorachek W. R., Pearson W. R., Rule G. S. Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus. Proc. Natl. Acad. Sci. U.S.A. 1991; 88: 4443
   PubMed Web of Science ®Google Scholar
• Campbell E., Takahashi Y., Abramovitz M., Peretz M., Listowsky I. A distinct human testis and brain μ-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type μ isoenzymes. J. Biol. Chem. 1990; 265: 9188
   PubMed Web of Science ®Google Scholar
• Suzuki T., Coggan M., Shaw D. C., Board P. G. Electrophoretic and immunological analysis of human glutathione S-transferase isozymes. Ann. Hum. Genet. 1987; 51: 95
   PubMed Web of Science ®Google Scholar
• Suzuki T., Shaw D. C., Board P. G. Purification and characterization of acidic glutathione S-transferase 6 from human brain. Biochem. J. 1991; 274: 405
   PubMed Web of Science ®Google Scholar
• Taylor J. B., Oliver J., Sherrington R., Pemble S. E. Structure of human glutathione S-transferase class mu genes. Biochem. J. 1991; 274: 587
   PubMed Web of Science ®Google Scholar
• Islam M. Q., Platz A., Szpirer J., Szpirer C., Levan G., Mannervik B. Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi. Hum. Genet. 1989; 82: 338
   PubMed Web of Science ®Google Scholar
• Comstock K. E., Sanderson B. J. S., Claflin G., Henner W. D. GST1 gene deletion determined by polymerase chain reaction. Nucleic Acids Res. 1990; 18: 3670
   PubMed Web of Science ®Google Scholar
• Marcus C. J., Habig W. H., Jakoby W. B. Glutathione transferase from human erythrocytes. Nonidentity with the enzymes from liver. Arch. Biochem. Biophys. 1978; 188: 287
   PubMed Web of Science ®Google Scholar
• Guthenberg C., Mannervik B. Glutathione S-transferase (transferase) from human placenta is identical or closely related to glutathione S-transferase (transferase) from erythrocytes. Biochim. Biophys. Acta 1981; 661: 255
   PubMed Web of Science ®Google Scholar
• Ahmad H., Wilson D. E., Fritz R. R., Singh S. V., Medh R. D., Nagle G. T., Awasthi Y. C., Kurosky A. Primary and secondary structural analyses of glutathione S-transferase from human placenta. Arch. Biochem. Biophys. 1990; 278: 398
   PubMed Web of Science ®Google Scholar
• Bora P. S., Spilburg C. A., Lange L. G. Metabolism of ethanol and carcinogens by glutathione transferases. Proc. Natl. Acad. Sci. U.S.A. 1989; 86: 4470
   PubMed Web of Science ®Google Scholar
• Suzuki T., Kovacs M. S., Board P. G. Do the major human glutathione S-transferases have fatty acid ethyl ester synthase activity. FEBS Lett. 1990; 275: 58
   PubMed Web of Science ®Google Scholar
• Ahmad H., Medh R. D., Singh S. V., Caccuri A. M., Ansari G. A. S., Awasthi Y. C. Anionic glutathione S-transferases of human erythrocytes, placenta, and lung: evidence for structural differences. Enzyme 1989; 42: 129
   PubMedGoogle Scholar
• Moscow J. A., Townsend A. J., Goldsmith M. E., Whang-Peng J., Vickers P. J., Poisson R., Legault-Poisson S., Myers C. E., Cowan K. H. Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 6518
   PubMed Web of Science ®Google Scholar
• Wong E. L., Kandpal G., Bale A. E. Two RFLPs at the glutathione S-transferase 3 gene. Nucleic Acids Res. 1990; 18: 4964
   PubMed Web of Science ®Google Scholar
• McLellan L. I., Wolf C. R., Hayes J. D. Human microsomal glutathione S-transferase. Its involvement in the conjugation of hexachlorobuta-1,3-diene with glutathione. Biochem. J. 1989; 258: 87
   PubMed Web of Science ®Google Scholar
• Van Ommen B., Bogaards J. J. P., Peters W. H. M., Blaauboer B., van Bladeren P. J. Quantification of human hepatic glutathione S-transferases. Biochem. J. 1990; 269: 609
   PubMed Web of Science ®Google Scholar
• Tateoka N., Tsuchida S., Soma Y., Sato K. Purification and characterization of glutathione S-transferases in human kidney. Clin. Chim. Acta. 1987; 166: 207
   PubMed Web of Science ®Google Scholar
• Singh S. V., Leal T., Ansari G. A. S., Awasthi Y. C. Purification and characterization of glutathione S-transferases of human kidney. Biochem. J. 1987; 246: 179
   PubMed Web of Science ®Google Scholar
• Koskelo K., Valmet E., Tenhunen R. Purification and characterization of an acid glutathione S-transferase from human lung. Scand. J. Clin. Lab. Invest. 1981; 41: 683
   PubMed Web of Science ®Google Scholar
• Theodore C., Singh S. V., Hong T. D., Awasthi Y. C. Glutathione S-transferases of human brain. Evidence for two immunologically distinct types of 26500-Mr subunits. Biochem. J. 1985; 225: 375
   PubMed Web of Science ®Google Scholar
• Peters W. H. M., Roelofs H. M. J., Nagengast F. M., Van Tongeren J. H. M. Human intestinal glutathione S-transferases. Biochem. J. 1989; 257: 471
   PubMed Web of Science ®Google Scholar
• Sherman M., Titmuss S., Kirsch R. E. Glutathione S-transferase in human organs. Biochem. Int. 1983; 6: 109
   PubMedGoogle Scholar
• Aceto A., Di Ilio C., Angelucci S., Felaco M., Federici G. Glutathione transferase isoenzymes from human testis. Biochem. Pharmacol. 1989; 38: 3653
   PubMed Web of Science ®Google Scholar
• Tew K. D., Clapper M. L., Greenberg R. E., Weese J. L., Hoffman S. J., Smith T. M. Glutathione S-transferases in human prostate. Biochim. Biophys. Acta 1987; 926: 8
   PubMed Web of Science ®Google Scholar
• Di Ilio C., Aceto A., Bucciarelli T., Angelucci S., Felaco M., Grilli A., Federici G. Glutathione transferase isoenzymes from human prostate. Biochem. J. 1990; 271: 481
   PubMed Web of Science ®Google Scholar
• Di Ilio C., Aceto A., Del Boccio G., Casalone E., Pennelli A., Federici G. Purification and characterization of five forms of glutathione transferase from human uterus. Eur. J. Biochem. 1988; 171: 491
   PubMedGoogle Scholar
• Hirrell P. A., Hume R., Fryer A. A., Collins M. F., Drew R., Bradwell A. R., Strange R. C. Studies on the developmental expression of glutathione S-transferase isoenzymes in human heart and diaphragm. Biochim. Biophys. Acta 1987; 915: 371
   PubMedGoogle Scholar
• Terrier P., Townsend A. J., Coindre J. M., Triche T. J., Cowan K. H. An immunohis-tochemical study of pi class glutathione S-transferase expression in normal human tissue. Am. J. Pathol. 1990; 137: 845
   PubMed Web of Science ®Google Scholar
• Campbell J. A. H., Corrigall A. V., Kirsch R. E. Immunohistologic localization of alpha, mu, and pi class glutathione S-transferases in human tissues. Cancer 1991; 67: 1608
   PubMed Web of Science ®Google Scholar
• Guthenberg C., Warholm M., Rane A., Mannervik B. Two distinct forms of glutathione transferase from human foetal liver. Biochem. J. 1986; 235: 741
   PubMed Web of Science ®Google Scholar
• Hiley C., Fryer A., Bell J., Hume R., Strange R. C. The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of alpha- and pi-class isoenzymes in liver. Biochem. J. 1988; 254: 255
   PubMed Web of Science ®Google Scholar
• Faulder C. G., Hirrell P. A., Hume R., Strange R. C. Studies of the development of basic, neutral and acidic isoenzymes of glutathione S-transferase in human liver, adrenal, kidney and spleen. Biochem. J. 1987; 241: 221
   PubMed Web of Science ®Google Scholar
• Beckett G. J., Howie A. F., Hume R., Matharoo B., Hiley C., Jones P., Strange R. C. Human glutathione S-transferases: radioimmunoassay studies on the expression of alpha-, mu- and pi-class isoenzymes in developing lung and kidney. Biochim. Biophys. Acta 1990; 1036: 176
   PubMed Web of Science ®Google Scholar
• Cossar D., Bell J., Strange R., Jones M., Sandison A., Hume R. The α and isoenzymes of glutathione S-transferase in human fetal lung: in utero ontogeny compared with differentiation in lung organ culture. Biochim. Biophys. Acta 1990; 1037: 221
   PubMed Web of Science ®Google Scholar
• Cowell I. G., Dixon K. H., Pemble S. E., Ketterer B., Taylor J. B. The structure of the human glutathione S-transferase gene. Biochem. J. 1988; 255: 79
   PubMed Web of Science ®Google Scholar
• Dixon K. H., Cowell I. G., Xia C. L., Pemble S. E., Ketterer B., Taylor J. B. Control of expression of the human glutathione S-transferase gene differs from its rat orthologue. Biochem. Biophys. Res. Commun. 1989; 163: 815
   PubMed Web of Science ®Google Scholar
• Morrow C. S., Goldsmith M. E., Cowan K. H. Regulation of human glutathione S-transferase gene transcription: influence of 5′-flanking sequences and trans-activating factors which recognize AP-1 binding site. Gene 1990; 88: 215
   PubMed Web of Science ®Google Scholar
• Xia C. L., Cowell I. G., Dixon K. H., Pemble S. E., Ketterer B., Taylor J. B. Glutathione transferase. Its minimal promoter and downstream cis-acting element. Biochem. Biophys. Res. Commun. 1991; 176: 233
   PubMed Web of Science ®Google Scholar
• Burgess J. R., Chow N.-W. I., Reddy C. C., Tu C.-P. D. Amino acid substitutions in the human glutathione S-transferases confer different specificities in the prostaglandin endoperoxide conversion pathway. Biochem. Biophys. Res. Commun. 1989; 158: 497
   PubMed Web of Science ®Google Scholar
• Vander Jagt D. L., Hunsaker L. A., Garcia K. B., Royer R. E. Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding site. J. Biol. Chem. 1985; 260: 11603
   PubMed Web of Science ®Google Scholar
• Seidegård J., Guthenberg C., Pero R. W., Mannervik B. The trans-stilbene oxide-active glutathione transferase in human mononuclear leukocytes is identical with the hepatic glutathione transferase μ. Biochem. J. 1987; 246: 783
   PubMed Web of Science ®Google Scholar
• Ogorochi T., Ujihara M L, Narumiya S. Purification and properties of prostaglandin H-E isomerase from the cytosol of human brain: identification as anionic forms of glutathione S-transferase. J. Neurochem. 1987; 48: 900
   PubMed Web of Science ®Google Scholar
• Robertson I. G. C., Guthenberg C., Mannervik B., Jernström B. Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7β, 8α-dihydroxy-9α,10α-oxy-7, 8,9,10-tetrahydrobenzo(a)pyrene. Cancer Res. 1986; 46: 2220
   PubMed Web of Science ®Google Scholar
• Berhane K., Mannervik B. Inactivation of the genotoxic aldehyde acrolein by human glutathione transferases of classes alpha, mu, and pi. Mol. Pharmacol. 1990; 37: 251
   PubMed Web of Science ®Google Scholar
• Morgenstern R., DePierre J. W. Microsomal glutathione transferase. Purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition. Eur. J. Biochem. 1983; 134: 591
   PubMedGoogle Scholar
• Warholm M., Jensson H., Tahir M. K., Mannervik B. Purification and characterization of three distinct glutathione transferases from mouse liver. Biochemistry 1986; 25: 4119
   PubMed Web of Science ®Google Scholar
• Hatayama I., Satoh K., Sato K. Developmental and hormonal regulation of the major form of hepatic glutathione S-transferase in male mice. Biochem. Biophys. Res. Commun. 1986; 140: 581
   PubMed Web of Science ®Google Scholar
• McLellan L. I., Hayes J. D. Differential induction of class alpha glutathione S-transferases in mouse liver by the anticarcinogenic antioxidant bu-tylated hydroxyanisole. Purification and characterization of glutathione S-transferase Ya1Ya1. Biochem. J. 1989; 263: 393
   PubMed Web of Science ®Google Scholar
• McLellan L. I., Kerr L. A., Cronshaw A. D., Hayes J. D. Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver. Biochem. J. 1991; 276: 461
   PubMed Web of Science ®Google Scholar
• Benson A. M., Hunkeler M. J., York J. L. Mouse hepatic glutathione transferase isoenzymes and their differential induction by anticarcinogens. Specificities of butylated hydroxyanisole and bisethylxan-thogen as inducers of glutathione transferases in male and female CD-1 mice. Biochem. J. 1989; 261: 1023
   PubMed Web of Science ®Google Scholar
• Daniel V., Sharon R., Bensimon A. Regulatory elements controlling the basal and drug-inducible expression of glutathione S-transferase Ya sub-unit gene. DNA 1989; 8: 399
   PubMedGoogle Scholar
• Friling R. S., Bensimon A., Tichauer Y., Daniel V. Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 6258
   PubMed Web of Science ®Google Scholar
• Pearson W. R., Windle J. J., Morrow J. F., Benson A. M., Talalay P. Increased synthesis of glutathione S-transferases in response to anti-carcinogenic antioxidant. Cloning and measurement of messenger RNA. J. Biol. Chem. 1983; 258: 2052
   PubMed Web of Science ®Google Scholar
• Hatayama I., Satoh K., Sato K. A cDNA sequence coding a class pi glutathione S-transferase of mouse. Nucleic Acids Res. 1990; 18: 4606
   PubMed Web of Science ®Google Scholar
• Medh R. D., Awasthi Y. C. Characterization and classification of mouse lung glutathione S-transferases. Clin. Chem. Enzyme Commun. 1990; 3: 267
   Google Scholar
• Gupta S., Medh R. D., Leal T., Awasthi Y. C. Selective expression of the three classes of glutathione S-transferase isoenzymes in mouse tissues. Toxicol. Appl. Pharmacol. 1990; 104: 533
   PubMed Web of Science ®Google Scholar
• Di Simplicio P., Jensson H., Mannervik B. Effects of inducers of drug metabolism on basic hepatic forms of mouse glutathione transferase. Biochem. J. 1989; 263: 679
   PubMed Web of Science ®Google Scholar
• Ramsdell H. S., Eaton D. L. Mouse liver glutathione S-transferase isoenzyme activity toward aflatoxin B1-8,9-epoxide and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide. Toxicol. Appl. Pharmacol. 1990; 105: 216
   PubMed Web of Science ®Google Scholar
• McLellan L. I., Hayes J. D. Differential regulation of murine glutathione S-transferases by xenobiotics. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, T. J. Mantle. Taylor & Francis, London 1990; 196
   Google Scholar
• Sisk S. C., Pearson W. R. Induction of murine glutathione transferases by BHA and other xenobiotics. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, T. J. Mantle. Taylor & Francis, London 1990; 222
   Google Scholar
• Chang L.-H., Chuang L.-F., Tsai C.-P., Tu C.-P. D., Tarn M. F. Characterization of glutathione S-transferases from day-old chick livers. Biochemistry 1990; 29: 744
   PubMed Web of Science ®Google Scholar
• Igarashi T., Namba E., Sagami F., Tsukidate K., Fukuda T., Horie T., Satoh T., Kitagawa H. Dog liver glutathione S-transferase and its strong immunoreactivity with rat transferase P(7-7). Biochem. Pharmacol. 1988; 37: 4713
   PubMed Web of Science ®Google Scholar
• Area P., Garcia P., Hardisson C., Suarez J. E. Purification and study of abacterial glutathione S-transferase. FEBS Lett. 1990; 263: 77
   PubMed Web of Science ®Google Scholar
• Overbaugh J. M., Lau E. P., Marino V. A., Fall R. Purification and preliminary characterization of a monomelic glutathione S-transferase fro. Tetrahymena thermophila, Arch. Biochem. Biophys. 1988; 261: 227
   PubMed Web of Science ®Google Scholar
• Jernström B., Martinez M., Meyer D. J., Ketterer B. Glutathione conjugation of the carcinogenic and mutagenic electrophile -7β, 8α-dihydroxy- 9α,10α- oxy-7,8,9,10- tetrahydrobenzo[a]pyrene catalyzed by purified rat liver glutathione transferases. Carcinogenesis (London) 1985; 6: 85
   PubMed Web of Science ®Google Scholar
• Robertson I. G. C., Jernström B. The enzymatic conjugation of glutathione with bay-region diol-epoxides of benzo[a]pyrene, benz[a]anthracene and chrysene. Carcinogenesis (London) 1986; 7: 1633
   PubMed Web of Science ®Google Scholar
• Hiratsuka A., Kawashima K., Watabe T., Satoh K., Hatayama I., Sato K. Inversion of enantioselectivity in glutathione conjugation of 9, 10-dihydrobenzo[a]pyrene 7,8-oxide in hepatic cytosol of rats following induction of hepatic hyperplastic nodules by chemical carcinogens. Cancer Lett. 1987; 38: 31
   PubMed Web of Science ®Google Scholar
• Coles B., Meyer D. J., Ketterer B., Stanton C. A., Garner R. C. Studies on the detoxication of microsomally-activated aflatoxin B1 by glutathione and glutathione transferase. in vitro, Carcinogenesis (London) 1985; 6: 693
   PubMed Web of Science ®Google Scholar
• Quinn B. A., Crane T. L., Kocal T. E., Best S. J., Cameron R. G., Rushmore T. H., Farber E., Hayes M. A. Protective activity of different hepatic cytosolic glutathione S-transferases against DNA-binding metabolites of aflatoxin B1. Toxicol. Appl. Pharmacol. 1990; 105: 351
   PubMed Web of Science ®Google Scholar
• Gopalan P., Santhanam K., Jhee E. C., Jensen D. E., Lotlikar P. D. Microsome mediated aflatoxin B1-8,9-epoxide conjugation to glutathione in presence of purified hepatic glutathione S-transferases from control and butylated hydroxyanisole pretreated rats. J. Toxicol. Toxin Rev. 1989; 8: 155
   Web of Science ®Google Scholar
• Stanley J. S., Benson A. M. The conjugation of 4-nitroquinoline 1-oxide, a potent carcinogen, by mammalian glutathione transferases. 4-Nitroquinoline 1-oxide conjugation by human, rat and mouse liver cytosols, extrahepatic organs of mice and purified mouse glutathione transferase isoenzymes. Biochem. J. 1988; 256: 303
   PubMed Web of Science ®Google Scholar
• Aceto A., Di Ilio C., Lo Bello M., Bucciarelli T., Angelucci S., Federici G. Differential activity of human, rat, mouse and bacteria glutathione transferase isoenzymes toward 4-nitroquinoline 1-oxide. Carcinogenesis (London) 1990; 11: 2267
   PubMed Web of Science ®Google Scholar
• Jensen D. E., Mackay R. L. Rat, mouse and hamster isozyme specificity in the glutathione transferase-mediated denitrosation of nitrosoguanidinium compounds. Cancer Res. 1990; 50: 1440
   PubMed Web of Science ®Google Scholar
• Saito K., Yamazoe Y., Kamataki T., Kato R. Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases. Carcinogenesis (London) 1983; 4: 1551
   PubMed Web of Science ®Google Scholar
• Litwack G., Ketterer B., Arias I. M. Ligandin: a hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions. Nature (London) 1971; 234: 466
   PubMed Web of Science ®Google Scholar
• Prohaska J. R., Ganther H. E. Glutathione peroxidase activity of glutathione-S-transferases purified from rat liver. Biochem. Biophys. Res. Commun. 1977; 76: 437
   Web of Science ®Google Scholar
• Tan K. H., Meyer D. J., Coles B., Ketterer B. Thymine hydroperoxide, a substrate for rat Sedependent glutathione peroxidase and glutathione transferase isoenzymes. FEBS Lett. 1986; 207: 231
   PubMed Web of Science ®Google Scholar
• Ketterer B., Meyer D. J., Clark A. G. Soluble glutathione transferase isoenzymes. Glutathione Conjugation, H. Sies, B. Ketterer. Academic Press, London 1988; 73
   Google Scholar
• Kitahara A., Satoh K., Nishimura K., Ishikawa T., Ruike K., Sato K., Tsuda H., Ito N. Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis. Cancer Res. 1984; 44: 2698
   PubMed Web of Science ®Google Scholar
• Satoh K., Kitahara A., Soma Y., Inaba Y., Hatayama I., Sato K. Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 1985; 82: 3964
   PubMed Web of Science ®Google Scholar
• Tahir M. K., Guthenberg C., Mannervik B. Glutathione transferases in rat hepatoma cells. Effects of ascites cells on the isoenzyme pattern in liver and induction of glutathione transferases in the tumour cells. Biochem. J. 1989; 257: 215
   PubMed Web of Science ®Google Scholar
• Sato K., Kitahara A., Yin Z., Waragai F., Nishimura K., Hatayama I., Ebina T., Yamazaki T., Tsuda H., Ito N. Induction by butylated hydroxyanisole of specific molecular forms of glutathione S-transferase and UDP-glucuronyltransferase and inhibition of development of γ-glutamyl transpeptidase-positive foci in rat liver. Carcinogenesis (London) 1984; 5: 473
   PubMed Web of Science ®Google Scholar
• Kensler T. W., Egner P. A., Davidson N. E., Roebuck B. D., Pikul A., Groopman J. D. Modulation of aflatoxin metabolism, aflatoxin-N′-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases. Cancer Res. 1986; 46: 3924
   PubMed Web of Science ®Google Scholar
• Davidson N. E., Egner P. A., Kensler T. W. Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver. Cancer Res. 1990; 50: 2251
   PubMed Web of Science ®Google Scholar
• Dwivedi P. P., Kumar A., Prasad A. K., Pandya K. P., Ray P. K. Induction of glutathione-S-transferase isoenzymes by protein A in rat liver. Biochem. Biophys. Res. Commun. 1990; 169: 476
   PubMed Web of Science ®Google Scholar
• Chang M., Burgess J. R., Scholz R. W., Reddy C. C. The induction of specific rat liver glutathione S-transferase subunits under inadequate selenium nutrition causes an increase in prostaglandin F2α formation. J. Biol. Chem. 1990; 265: 5418
   PubMed Web of Science ®Google Scholar
• Igarashi T., Irokawa N., Ono S. Difference in the effects of phenobarbital and 3-methylcholan-threne treatment on subunit composition of hepatic glutathione S-transferase in male and female rats. Xenobiotica 1987; 17: 127
   PubMed Web of Science ®Google Scholar
• Prochaska H. J., Talalay P. Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver. Cancer Res. 1988; 48: 4776
   PubMed Web of Science ®Google Scholar
• Talalay P., De Long M. J., Prochaska H. J. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 8261
   PubMed Web of Science ®Google Scholar
• Spencer S. R., Xue L., Klenz E. M., Talalay P. The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations. Biochem. J. 1991; 273: 711
   PubMed Web of Science ®Google Scholar
• Foliot A., Touchard D., Mallet L. Inhibition of liver glutathione S-transferase activity in rats by hypolipidemic drugs related or unrelated to clo-fibrate. Biochem. Pharmacol. 1986; 35: 1685
   PubMed Web of Science ®Google Scholar
• Reddy J. K., Azarnoff D. L., Hignite C. E. Hypolipidemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature (London) 1980; 283: 397
   PubMed Web of Science ®Google Scholar
• Marsman D. S., Cattley R. C., Conway J. G., Popp J. A. Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ehtylhexyl)phthalate and [4-chloro-6-(2, 3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14643) in rats. Cancer Res. 1988; 48: 6739
   PubMed Web of Science ®Google Scholar
• Reddy J. K., Rao M. S. Peroxisome proliferators and cancer: mechanisms and implications. Trends Pharmacol. Sci. 1986; 7: 438
   Web of Science ®Google Scholar
• Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (London) 1990; 347: 645
   PubMed Web of Science ®Google Scholar
• Landers J. P., Bunce N. J. The Ah receptor and the mechanism of dioxin toxicity. Biochem. J. 1991; 276: 273
   PubMed Web of Science ®Google Scholar
• Wattenberg L. W., Hanley A. B., Barany G., Sparnins V. L., Lam L. K. T., Fenwick G. R. Inhibition of carcinogenesis by some minor dietary constituents. Diet, Nutrition and Cancer, Y. Hayashi, M. Nagao, T. Sugimura, S. Takayama, L. Tomatis, L. W. Wattenberg, G. N. Wogan. Japan Science Society Press, Tokyo/VNU Scientific Press, Utrecht 1986; 193
   Google Scholar
• Lotlikar P. D., Jhee E. C., Insetta S. M., Clearfield M. S. Modulation of microsome-mediated aflatoxin B1 binding to exogenous and endogenous DNA by cytosolic glutathione S-transferases in rat and hamster livers. Carcinogenesis (London) 1984; 5: 269
   PubMed Web of Science ®Google Scholar
• Lotlikar P. D., Raj H. G., Bohm L. S., Ho L. L., Jhee E.-C., Tsuji K., Gopalan P. A mechanism of inhibition of aflatoxin B1-DNA binding in the liver by phenobarbital pretreatment of rats. Cancer Res. 1989; 49: 951
   PubMed Web of Science ®Google Scholar
• Jhee E.-C., Ho L. L., Tsuji K., Gopalan P., Lotlikar P. D. Effect of butylated hydroxy-anisole pretreatment of aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation in isolated hepatocytes from rats. Cancer Res. 1989; 49: 1357
   PubMed Web of Science ®Google Scholar
• Rogers C. G., Boyes B. G., Lok E. Comparative genotoxicity of 3 procarcinogens in V79 cells as related to glutathione S-transferase activity of he-patocytes from untreated rats and those fed 2% butylated hydroxyanisole. Mutat. Res. 1990; 244: 163
   PubMedGoogle Scholar
• Singh S. V., Creadon G., Das M., Mukhtar H., Awasthi Y. C. Glutathione S-transferases of mouse lung. Selective binding of benzo[a]pyrene metabolites by the subunits which are preferentially induced by t-butylated hydroxyanisole. Biochem. J. 1987; 243: 351
   PubMed Web of Science ®Google Scholar
• Monks T. J., Anders M. W., Dekant W., Stevens J. L., Lau S. S., Van Bladeren P. J. Contemporary issues in toxicology: glutathione conjugate mediated toxicities. Toxicol. Appl. Pharmacol. 1990; 106: 1
   PubMed Web of Science ®Google Scholar
• Vamvakas S., Anders M. W. Formation of reactive intermediates by phase II enzymes: glutathione-dependent bioactivation reactions. Biological Reactive Intermediates IV, C. M. Mitmer. Plenum Press, New York 1990; 13
   Google Scholar
• Ozawa N., Guengerich F. P. Evidence for formation of an S-[2-(N′-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA. Proc. Natl. Acad. Sci. U.S.A. 1983; 80: 5266
   PubMed Web of Science ®Google Scholar
• Cmarik J. L., Inskeep P. B., Meredith M. J., Meyer D. J., Ketterer B., Guengerich F. P. Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes. Cancer Res. 1990; 50: 2747
   PubMed Web of Science ®Google Scholar
• Kim D.-H., Guengerich F. P. Formation of the DNA adduct S-[2-(N′- guanyl)ethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis (London) 1990; 11: 419
   PubMed Web of Science ®Google Scholar
• Romert L., Magnusson J., Ramel C. The importance of glutathione and glutathione transferase for somatic mutations in Drosophila melanogaster induced in vivo by 1, 2-dichloroethane. Carcinogenesis (London) 1990; 11: 1399
   PubMed Web of Science ®Google Scholar
• Pearson P. G., Soderlund E. J., Dybing E., Nelson S. D. Metabolic activation of 1,2-dibromo-3-chloropropane: evidence for the formation of reactive episulfonium ion intermediates. Biochemistry 1990; 29: 4971
   PubMed Web of Science ®Google Scholar
• Anders M. W., Lash L. H., Dekant W., Elfarra A. A., Dohn D. R. Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. CRC Crit. Rev. Toxicol. 1988; 18: 311
   Web of Science ®Google Scholar
• Shigefuku T. An experimental study on the relation of changes in the liver caused by parasites and the development of cancer of the liver. Jikken Igaku Z. 1943; 27: 356
   Google Scholar
• Domingo E. O., Warren K. S., Stenger R. J. Increased incidence of hepatoma in mice with chronic schistosomiasis mansoni treated with a carcinogen. Am. J. Pathol. 1967; 51: 307
   PubMed Web of Science ®Google Scholar
• Miyasato M. Experimental study of the influence of Schistosoma japonicum infection on carcinogenesis of mice liver treated with N-2-fluorenylacetamide (2-FAA). Jpn. J. Parasit. 1984; 33: 41
   Google Scholar
• Gentile J. M., de Ruiter E. Promutagen activation in parasite infected organisms: preliminary observations with Fasciola hepatica-infected mice and aflatoxin B1. Toxicol. Lett. 1981; 8: 273
   PubMed Web of Science ®Google Scholar
• Jang J. J., Cho K. J., Myong N. H., Chai J. Y. Enhancement of dimethylnitrosamine-induced glutathione S-transferase P-positive hepatic foci by Clonorchis sinensis infestation in F344 rats. Cancer Lett. 1990; 52: 133
   PubMed Web of Science ®Google Scholar
• Thamavit W., Ngamying M., Boonpucknavig V., Boonpucknavig S., Moore M. A. Enhancement of DEN-induced hepatocellular nodule development by Opisthorchis viverrinie infection in Syrian golden hamsters. Carcinogenesis (London) 1987; 8: 1351
   PubMed Web of Science ®Google Scholar
• Smith D. B., Davern K. M., Board P. G., Tiu W. U., Garcia E. G., Mitchell G. F. Mr 26,000 antigen of Schistosoma japonicum recognized by resistant WEHI 129/J mice is a parasite glutathione S-transferase. Proc. Natl. Acad. Sci. U.S.A. 1986; 83: 8703
   PubMed Web of Science ®Google Scholar
• Balloul J. M., Sondermeyer P., Dreyer D., Capron M., Grzych J. M., Pierce R. J., Carvallo D., Lecocq J. P., Capron A. Molecular cloning of a protective antigen of schistosomes. Nature (London) 1987; 326: 149
   PubMed Web of Science ®Google Scholar
• Taylor J. B., Vidal A., Torpier G., Meyer D. J., Roitsch C., Balloul J.-M., Southan C., Sondermeyer P., Pemble S., Lecocq J.-P., Capron A., Ketterer B. The glutathione transferase activity and tissue distribution of a cloned Mr 28K protective antigen o. Schistosoma mansoni, EMBO J. 1988; 7: 465
   PubMed Web of Science ®Google Scholar
• O'Leary K. A., Tracy J. W. Purification of three cytosolic glutathione S-transferases from adul. Schistosoma mansoni. Arch. Biochem. Biophys. 1988; 264: 1
   PubMed Web of Science ®Google Scholar
• Sexton J. L., Milner A. R., Panaccio M., Waddington J., Wijffels G., Chandler D., Thompson C., Wilson L., Spithill T. W., Mitchell G. F., Campbell N. J. Glutathione S-transferase. Novel vaccine against Fasciola hepatica infection in sheep. J. Immunol 1990; 145: 3905
   PubMed Web of Science ®Google Scholar
• Cha Y.-N., Edwards R. Effects of Schistosoma mansoni infection on the hepatic drug-metabolizing capacity of mice. J. Pharmacol. Exp. Ther. 1976; 199: 432
   PubMed Web of Science ®Google Scholar
• Matsuoka H., Aji T., Ishii A., Arimoto S., Wataya Y., Hayatsu H. Reduced levels of mutagen processing potential in Schistosoma japonicum-infected mouse liver. Mutat. Res. 1989; 227: 153
   PubMedGoogle Scholar
• Siwela A. H., Nyathi C. B., Chetsanga C. J., Hasler J. A. The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo an. in vitro, Biochem. Pharmacol. 1990; 40: 379
   PubMed Web of Science ®Google Scholar
• Adams D. J., Balkwill F. R., Griffin D. B., Hayes J. D., Lewis A. D., Wolf C. R. Induction and suppression of glutathione transferases by interferon in the mouse. J. Biol. Chem. 1987; 262: 4888
   PubMed Web of Science ®Google Scholar
• Kitahara A., Satoh K., Sato K. Properties of the increased glutathione S-transferase A form in rat preneoplastic hepatic lesions induced by chemical carcinogens. Biochem. Biophys. Res. Commun. 1983; 112: 20
   PubMed Web of Science ®Google Scholar
• Sato K., Kitahara A., Satoh K., Ishikawa T., Tatematsu M., Ito N. The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Jpn. J. Cancer Res. (Gann) 1984; 75: 199
   Google Scholar
• Ketterer B., Coles B., Meyer D. J. The role of glutathione in detoxication. Environ. Health Perspect. 1983; 49: 59
   PubMed Web of Science ®Google Scholar
• Guthenberg C., Jensson H., Nyström L., Österlund E., Tahir M. K., Mannervik B. Isoenzymes of glutathione transferase in rat kidney cytosol. Biochem. J. 1985; 230: 609
   PubMed Web of Science ®Google Scholar
• Robertson I. G. C., Jensson H., Mannervik B., Jernström B. Glutathione transferases in rat lung: the presence of transferase 7-7, highly efficient in the conjugation of glutathione with the carcinogenic (+) -7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Carcinogenesis (London) 1986; 7: 295
   PubMed Web of Science ®Google Scholar
• Hayes J. D. Selective elution of rodent glutathione S-transferases and glyoxalase I from the S-hexylglutathione-Sepharose affinity matrix. Biochem. J. 1988; 255: 913
   PubMed Web of Science ®Google Scholar
• Solt D., Farber E. New principle for the analysis of chemical carcinogenesis. Nature (London) 1976; 263: 701
   Web of Science ®Google Scholar
• Sugioka Y., Fujii-Kuriyama Y., Kitagawa T., Muramatsu M. Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis. Cancer Res. 1985; 45: 365
   PubMed Web of Science ®Google Scholar
• Jensson H., Eriksson L. C., Mannervik B. Selective expression of glutathione transferase isoenzymes in chemically induced preneoplastic rat hepatocyte nodules. FEBS Lett. 1985; 187: 115
   PubMed Web of Science ®Google Scholar
• Eriksson L. C., Sharma R. N., Roomi M. W., Ho R. K., Farber E., Murray R. K. A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules generated during liver carcinogenesis in several models. Biochem. Biophys. Res. Commun. 1983; 117: 740
   PubMed Web of Science ®Google Scholar
• Rushmore T. H., Sharma R. N. S., Roomi M. W., Harris L., Satoh K., Sato K., Murray R. K., Farber E. Identification of a characteristic cytosolic polypeptide of rat preneoplastic hepatocyte nodules as placental glutathione S-transferase. Biochem. Biophys. Res. Commun. 1987; 143: 98
   PubMed Web of Science ®Google Scholar
• Rushmore T. H., Harris L., Nagai M., Sharma R. N., Hayes M. A., Cameron R. G., Murray R. K., Farber E. Purification and characterization of P-52 (glutathione S-transferase-P or 7-7) from normal liver and putative preneoplastic liver nodules. Cancer Res. 1988; 48: 2805
   PubMed Web of Science ®Google Scholar
• Mitaka T., Tsukada H. Sexual difference in the histochemical characteristics of “altered cell foci” in the liver of aged Fischer 344 rats. Jpn. J. Cancer Res. (Gann) 1987; 78: 785
   PubMedGoogle Scholar
• Oyamada M., Dempo K., Fujimoto Y., Takahashi H., Satoh M. I., Mori M., Masuda R., Yoshida M. C., Satoh K., Sato K. Spontaneous occurrence of placental glutathione S-transferase-positive foci in the livers of LEC rats. Jpn. J. Cancer Res. (Gann) 1988; 79: 5
   PubMedGoogle Scholar
• Masuda R., Yoshida M. C., Sasaki M. Gene expression of placental glutathione S-transferase in hereditary hepatitis and spontaneous hepatocarcinogenesis of LEC strain rats. Jpn. J. Cancer Res. 1989; 80: 1024
   PubMedGoogle Scholar
• Moore M. A., Nakamura T., Ito N. Immunohistochemically demonstrated glucose-6-phosphate dehydrogenase, γ-glutamyl transpeptidase, ornithine decarboxylase and glutathione S-transferase enzymes: absence of direct correlation with cell proliferation in rat liver putative preneoplastic lesions. Carcinogenesis (London) 1986; 7: 1419
   PubMed Web of Science ®Google Scholar
• Moore M. A., Nakagawa K., Satoh K., Ishikawa T., Sato K. Single GST-P positive liver cells — putative initiated hepatocytes. Carcinogenesis (London) 1987; 8: 483
   PubMed Web of Science ®Google Scholar
• Satoh K., Hatayama I., Tateoka N., Tamai K., Shimizu T., Tatematsu M., Ito N., Sato K. Transient induction of single GST-P positive hepatocytes by DEN. Carcinogenesis (London) 1989; 10: 2107
   PubMed Web of Science ®Google Scholar
• Takahashi S., Tsutsumi M., Nakae D., Denda A., Kinugasa T., Konishi Y. Persistent effect of a low dose of preadministered diethylnitrosamine on the induction of enzyme-altered foci in rat liver. Carcinogenesis (London) 1987; 8: 509
   PubMed Web of Science ®Google Scholar
• Ito N., Tsuda H., Tatematsu M., Inoue T., Tagawa Y., Aoki T., Uwagawa S., Kagawa M., Ogiso T., Masui T., Imaida K., Fukushima S., Asamoto M. Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats — an approach for a new medium-term bioassay system. Carcinogenesis (London) 1988; 9: 387
   PubMed Web of Science ®Google Scholar
• Tatematsu M., Tsuda H., Shirai T., Masui T., Ito N. Placental glutathione S-transferase (GSTP) as a new marker for hepatocarcinogenesis: in vivo short-term screening for hepatocarcinogens. Toxicol. Path. 1987; 15: 60
   PubMed Web of Science ®Google Scholar
• Tatematsu M., Aoki T., Kagawa M., Mera Y., Ito N. Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats. Carcinogenesis (London) 1988; 9: 221
   PubMed Web of Science ®Google Scholar
• Thamavit W., Tatematsu M., Ogiso T., Mera Y., Tsuda H., Ito N. Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase. Cancer Lett. 1985; 27: 295
   PubMed Web of Science ®Google Scholar
• Manson M. M., Green J. A., Driver H. E. Ethoxyquin alone induces preneoplastic changes in rat kidney while preventing induction of such lesions in liver by aflatoxin B1. Carcinogenesis (London) 1987; 8: 723
   PubMed Web of Science ®Google Scholar
• Roomi M. W., Columbano A., Ledda-Columbano G. M., Sarma D. S. R. Lead nitrate induces certain biochemical properties characteristic of hepatocyte nodules. Carcinogenesis (London) 1986; 7: 1643
   PubMed Web of Science ®Google Scholar
• Roomi M. W., Columbano A., Ledda-Coiumbano G. M., Sarma D. S. R. Induction of the placental form of glutamione S-transferase by lead nitrate administration in rat liver. Toxicol. Pathol. 1987; 15: 202
   PubMed Web of Science ®Google Scholar
• Columbano A., Ledda-Columbano G. M., Ennas M. G., Curto M., Chelo A., Pani P. Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci. Carcinogenesis (London) 1990; 11: 771
   PubMed Web of Science ®Google Scholar
• Columbano A., Ledda-Columbano G. M., Coni P., Pani P. Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis. Carcinogenesis (London) 1987; 8: 345
   PubMed Web of Science ®Google Scholar
• Columbano A., Ledda-Columbano G. M., Lee G., Rajalakshmi S., Sarma D. S. R. Inability of mitogen-induced liver hyperplasia to support the induction of enzyme-altered islands induced by liver carcinogens. Cancer Res. 1987; 47: 5557
   PubMed Web of Science ®Google Scholar
• Tatematsu M., Mera Y., Inoue T., Satoh K., Sato K., Ito N. Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of γ-glutamyl-transferase in rat liver preneoplastic and neoplastic lesions. Carcinogenesis (London) 1988; 9: 215
   PubMed Web of Science ®Google Scholar
• Xu Y.-H., Maronpot R., Pitot H. C. Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis. Carcinogenesis (London) 1990; 11: 267
   PubMed Web of Science ®Google Scholar
• Xu Y.-H., Campbell H. A., Sattler G. L., Hendrich S., Maronpot R., Sato K., Pitot H. C. Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers. Cancer Res. 1990; 50: 472
   PubMed Web of Science ®Google Scholar
• Hasegawa R., Mutai M., Imaida K., Tsuda H., Yamaguchi S., Ito N. Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver. Jpn. J. Cancer Res. 1989; 80: 945
   PubMedGoogle Scholar
• Imaida K., Tatematsu M., Kato T., Tsuda H., Ito N. Advantages and limitations of stereo-logical estimation of placental glutathione S-transferase-positive rat liver cell foci by computerized three-dimensional reconstruction. Jpn. J. Cancer Res. 1989; 80: 326
   PubMedGoogle Scholar
• Yokota K., Singh U., Shinozuka H. Effects of a choline-deficient diet and a hypolipidemic agent on single glutathione S-transferase placental form-positive hepatocytes in rat liver. Jpn. J. Cancer Res. 1990; 81: 129
   PubMedGoogle Scholar
• Ito N., Imaida K., Hasegawa R., Tsuda H. Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis. CRC Crit. Rev. Toxicol 1989; 19: 385
   Web of Science ®Google Scholar
• Rao M. S., Reddy J. K. Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis (London) 1987; 8: 631
   PubMed Web of Science ®Google Scholar
• Numoto S., Furukawa K., Furuya K., Williams G. M. Effects of the hepatocarcinogenic peroxisome-proliferating hypolipidemic agents clofibrate and nafenopin on the rat liver cell membrane enzymes γ-glutamyltranspeptidase and alkaline phosphatase and on the early stages of liver carcinogenesis. Carcinogenesis (London) 1984; 5: 1603
   PubMed Web of Science ®Google Scholar
• Glauert H. P., Beer D., Rao M. S., Schwarz M., Xu Y.-D., Goldsworthy T. L., Coloma J., Pitot H. C. Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine. Cancer Res. 1986; 46: 4601
   PubMed Web of Science ®Google Scholar
• Greaves P., Irisarri E., Monro A. M. Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. J. Natl. Cancer Inst. 1986; 76: 475
   PubMedGoogle Scholar
• Hendrich S., Campbell H. A., Pitot H. C. Quantitative stereological evaluation of four histochemical markers of altered foci in multistage hepatocarcinogenesis in the rat. Carcinogenesis (London) 1987; 8: 1245
   PubMed Web of Science ®Google Scholar
• Wirth P. J., Rao M. S., Evarts R. P. Coordinate polypeptide expression during hepatocarcinogenesis in male F-344 rats: comparison of the Solt-Farber and Reddy models. Cancer Res. 1987; 47: 2839
   PubMed Web of Science ®Google Scholar
• Awasthi Y. C., Singh S. V., Goel S. K., Reddy J. K. Irreversible inhibition of hepatic glutathione S-transferase by ciprofibrate, a peroxisome proliferator. Biochem. Biophys. Res. Commun. 1984; 123: 1012
   PubMed Web of Science ®Google Scholar
• Rao M. S., Nemali M. R., Usuda N., Scarpelli D. G., Makino T., Pitot H. C., Reddy J. K. Lack of expression of glutathione-S-transferase P, γ-glutamyl transpeptidase and α-fetoprotein mRNAs in liver tumors induced by peroxisome proliferators. Cancer Res. 1988; 48: 4919
   PubMed Web of Science ®Google Scholar
• Kasai H., Okada Y., Nishimura S., Rao M. S., Reddy J. K. Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator. Cancer Res. 1989; 49: 2603
   PubMed Web of Science ®Google Scholar
• Takagi A., Sai K., Umemura T., Hasegawa R., Kurokawa Y. Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate. Jpn. J. Cancer Res. 1990; 81: 213
   PubMedGoogle Scholar
• Muramatsu M., Okuda A., Kano T., Sakai M. Structure and regulation of rat glutathione S-transferase P (GST-P) gene. Glutathione S-transferases and Carcinogenesis, T. J. Mantle, C. B. Pickett, J. D. Hayes. Taylor & Francis, London 1987; 111
   Google Scholar
• Masuda R., Yoshida M. C., Sasaki M., Okuda A., Sakai M., Muramatsu M. Localization of the gene for glutathione S-transferase P on rat chromosome 1 at band q43. Jpn. J. Cancer Res. (Gann) 1986; 77: 1055
   PubMedGoogle Scholar
• Okuda A., Imagawa M., Maeda Y., Sakai M., Muramatsu M. Structural and functional analysis of an enhancer GPEI having a phorbol 12-O-tetradecanoate 13-acetate responsive element-like sequence found in the rat glutathione transferase P gene. J. Biol. Chem. 1989; 264: 16919
   PubMed Web of Science ®Google Scholar
• Sakai M., Okuda A., Hatayama I., Sato K., Nishi S., Muramatsu M. Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis. Cancer Res. 1989; 49: 5633
   PubMed Web of Science ®Google Scholar
• Rauscher F. J., III, Sambucetti L. C., Curran T., Distel R. J., Spiegelman B. M. A common DNA binding site for fos protein complexes and transcription factor AP-1. Cell 1988; 52: 471
   PubMed Web of Science ®Google Scholar
• Sato K., Satoh K., Tsuchida S., Hatayama I., Tamai K., Shen H. Glutathione S-transferases and (pre)neoplasia. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, T. J. Mantle. Taylor & Francis, London 1990; 389
   Google Scholar
• Power C., Sinha S., Webber C., Manson M. M., Neal G. E. Transformation related expression of glutathione-S-transferase P in rat liver cells. Carcinogenesis (London) 1987; 8: 797
   PubMed Web of Science ®Google Scholar
• Burt R. K., Garfield S., Johnson K., Thorgeirsson S. S. Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals. Carcinogenesis (London) 1988; 9: 2329
   PubMed Web of Science ®Google Scholar
• Li Y., Seyama T., Godwin A. K., Winokur T. S., Lebovitz R. M., Lieberman M. W. MTrasT24, a metallothionein-ras fusion gene, modulates expression in cultured rat liver cells of two genes associated with in vivo liver cancer. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 344
   PubMed Web of Science ®Google Scholar
• Pitot H. C., Goodspeed D., Dunn T., Hendrich S., Maronpot R. R., Moran S. Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis. Toxicol. Appl. Pharmacol. 1989; 97: 23
   PubMed Web of Science ®Google Scholar
• Winokur T. S., Lieberman M. W. Immunofluorescent analysis of γ-glutamyltranspeptidase and glutamione-S-transferase-P during the initial phase of experimental hepatocarcinogenesis. Carcinogenesis (London) 1990; 11: 365
   PubMed Web of Science ®Google Scholar
• Fukai F., Yatomi S., Morita T., Nishizawa S., Nagai T., Katayama T. Protection of glutathione S-transferase from bilirubin inhibition. J. Biochem. (Tokyo) 1989; 105: 968
   PubMed Web of Science ®Google Scholar
• Ketterer B., Coles B., Meyer D. J. Detoxication reaction of glutathione and glutathione transferases. Xenobiotic Metabolism and Disposition. Proceedings of the 2nd International ISSX Meeting, R. Kato, R. W. Estabrook, M. N. Cayen. Taylor & Francis, London 1989; 55
   Google Scholar
• Sato K., Tsuchida S., Satoh K., Hatayama I., Ishikawa T., Tamai K. Properties and functions of neutral and acidic glutathione S-transferases. Glutathione Centennial. Molecular Perspectives and Clinical Implications, N. Taniguchi, T. Higashi, Y. Sakamoto, A. Meister. Academic Press, San Diego 1989; 259
   Google Scholar
• Aniya Y., Anders M. W. Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species. J. Biol. Chem. 1989; 264: 1998
   PubMed Web of Science ®Google Scholar
• Ziegler D. M. Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation. Annu. Rev. Biochem. 1985; 54: 305
   PubMed Web of Science ®Google Scholar
• Pickett C. B., Williams J. B., Lu A. Y. H., Cameron R. G. Regulation of glutathione transferase and DT-diaphorase mRNAs in persistent hepatocyte nodules during chemical hepatocarcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 1984; 81: 5091
   PubMed Web of Science ®Google Scholar
• Farber E. Chemicals, evolution, and cancer development. Am. J. Pathol. 1982; 108: 270
   PubMed Web of Science ®Google Scholar
• Harrison D. J., May L., Hayes J. D., Neal G. E. Glutathione S-transferase localization in aflatoxin B1-treated rat livers. Carcinogenesis (London) 1990; 11: 927
   PubMed Web of Science ®Google Scholar
• Kodate C., Fukushi A., Narita T., Kudo H., Soma Y., Sato K. Human placental form of glutathione S-transferase (GST) as a new immunohistochemical marker for human colonic carcinoma. Jpn. J. Cancer Res. (Gann) 1986; 77: 226
   PubMedGoogle Scholar
• Shiratori Y., Soma Y., Maruyama H., Sato S., Takano A., Sato K. Immunohistochemical detection of the placental form of glutathione S-transferase in dysplastic and neoplastic human uterine cervix lesions. Cancer Res. 1987; 47: 6806
   PubMed Web of Science ®Google Scholar
• Di Ilio C., Del Boccio G., Aceto A., Casaccia R., Mucilli F., Federici G. Elevation of glutathione transferase activity in human lung tumor. Carcinogenesis (London) 1988; 9: 335
   PubMed Web of Science ®Google Scholar
• Eimoto H., Tsutsumi M., Nakajima A., Yamamoto K., Takashima Y., Maruyama H., Konishi Y. Expression of the glutathione S-transferase placental form in human lung carcinomas. Carcinogenesis (London) 1988; 9: 2325
   PubMed Web of Science ®Google Scholar
• Awasthi Y. C., Singh S. V., Ahmad H., Moller P. C., Gupta V. Expression of glutathione S-transferase isoenzymes in human small cell lung cancer cell lines. Carcinogenesis (London) 1988; 9: 89
   PubMed Web of Science ®Google Scholar
• Nakagawa K., Yokota J., Wada M., Sasaki Y., Fujiwara Y., Sakai M., Muramatsu M., Terasaki T., Tsunokawa Y., Terada M., Saijo N. Levels of glutathione S-transferase mRNA in human lung cancer cell lines correlate with the resistance to cisplatin and carboplatin. Jpn. J. Cancer Res. (Gann) 1988; 79: 301
   PubMedGoogle Scholar
• Hara A., Yamada H., Sakai N., Hirayama H., Tanaka T., Mori H. Immunohistochemical demonstration of the placental form of glutathione S-transferase, a detoxifying enzyme in human gliomas. Cancer 1990; 66: 2563
   PubMed Web of Science ®Google Scholar
• Hanada K., Ishikawa H., Tamai K., Hashimoto I., Sato K. Expression of glutathione S-transferase in malignant skin tumors. J. Dermatol. Sci. 1991; 2: 18
   PubMedGoogle Scholar
• Harrison D. J., Hallam L., Lauder J. Glutathione S-transferase expression in fetal kidney and Wilms' tumour. Br. J. Cancer 1990; 61: 836
   PubMed Web of Science ®Google Scholar
• Mannervik B., Castro V. M., Danielson U. H., Tahir M. K., Hansson J., Ringborg U. Expression of class pi glutathione transferase in human malignant melanoma cells. Carcinogenesis (London) 1987; 8: 1929
   PubMed Web of Science ®Google Scholar
• Shea T. C., Kelley S. L., Henner W. D. Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines. Cancer Res. 1988; 48: 527
   PubMed Web of Science ®Google Scholar
• Schisselbauer J. C., Silber R., Papadopoulos E., Abrams K., LaCreta F. P., Tew K. D. Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients. Cancer Res. 1990; 50: 3562
   PubMed Web of Science ®Google Scholar
• Hall A., Foster S., Proctor S. J., Cattan A. R. Purification and characterization of a pi class glutathione S-transferase from human leukaemic cells. Br. J. Haematol. 1990; 76: 494
   PubMed Web of Science ®Google Scholar
• Sato K., Satoh K., Hatayama I., Tsuchida S., Soma Y., Shiratori Y., Tateoka N., Inaba Y., Kitahara A. Placental glutathione S-transferase as a marker for (pre)neoplastic tissues. Glutathione S-transferases and Carcinogenesis, T. J. Mantle, C. B. Pickett, J. D. Hayes. Taylor & Francis, London 1987; 127
   Google Scholar
• Hayes P. C., Portmann B., Aldis P. M., Williams R., Hayes J. D. Glutathione S-transferases and human pathology. Glutathione S-transferases and Carcinogenesis, T. J. Mantle, C. B. Pickett, J. D. Hayes. Taylor & Francis, London 1987; 175
   Google Scholar
• De Camargo J. L. V., Tsuda H., Tatematsu M., Rodrigues M. A. M., Yamada M., Tzuji K., Ito N. Placental form of glutathione S-transferase in normal and diseased human uterine cervical mucosa. Carcinogenesis (London) 1989; 10: 2317
   PubMed Web of Science ®Google Scholar
• Randall B. J., Angus B., Akiba R., Hall A., Cattan A. R., Proctor S. J., Jones R. A., Home C. H. W. Glutathione S-transferase (placental) as a marker of transformation in the human cervix uteri: an immunohistochemical study. Br. J. Cancer 1990; 62: 614
   PubMed Web of Science ®Google Scholar
• Chan S. Y., Shih P., Davis J. M., Longo D., Kantor R. R. S. Glutathione S-transferase-pi (GST-pi), an early marker for human papillomavirus (HPV)-induced cervical neoplasm. Proc. Am. Assoc. Cancer Res. 1990; 31: 166
   Google Scholar
• Kodate C., Tsuchida S., Saito H., Sato K., unpublished results
   Google Scholar
• Fearon E. R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759
   PubMed Web of Science ®Google Scholar
• Howie A. F., Forrester L. M., Glancey M. J., Schlager J. J., Powis G., Beckett G. J., Hayes J. D., Wolf C. R. Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues. Carcinogenesis (London) 1990; 11: 451
   PubMed Web of Science ®Google Scholar
• Mouelhi M. E., Didolkar M. S., Elias E. G., Guengerich F. P., Kauffman F. C. Hepatic drug-metabolizing enzymes in primary and secondary tumors of human liver. Cancer Res. 1987; 47: 460
   PubMed Web of Science ®Google Scholar
• Di Ilio C., Del Boccio G., Aceto A., Federici G. Alteration of glutathione transferase isoenzyme concentrations in human renal carcinoma. Carcinogenesis (London) 1987; 8: 861
   PubMed Web of Science ®Google Scholar
• Howie A. F., Miller W. R., Hawkins R. A., Hutchinson A. R., Beckett G. J. Expression of glutathione S-transferase B1, B2, mu and pi in breast cancers and their relationship to oestrogen receptor status. Br. J. Cancer 1989; 60: 834
   PubMed Web of Science ®Google Scholar
• Molina R., Fuqua S. A. W., Tandon A. K., Clark G. M., Allred D. C., Townsend A. J., Moscow J. A., Cowan K. H., McGuire W. L. Glutathione transferase GST-pi in breast tumors evaluated by three techniques. Proc. Am. Assoc. Cancer Res. 1990; 31: 7
   Google Scholar
• Shea T. C., Claflin G., Comstock K. E., Sanderson B. J. S., Burstein N. A., Keenan E. J., Mannervik B., Henner W. D. Glutathione transferase activity and isoenzyme composition in primary human breast cancers. Cancer Res. 1990; 50: 6848
   PubMed Web of Science ®Google Scholar
• Forrester L. M., Hayes J. D., Millis R., Barnes D., Harris A. L., Schlager J. J., Powis G., Wolf C. R. Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue. Carcinogenesis (London) 1990; 11: 2163
   PubMed Web of Science ®Google Scholar
• Batist G., Tulpule A., Sinha B. K., Katki A. G., Meyers C. E., Cowan K. H. Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J. Biol. Chem. 1986; 261: 15544
   PubMed Web of Science ®Google Scholar
• Niitsu Y., Takahashi Y., Saiot T., Hirata Y., Arisato N., Maruyama H., Kohgo Y., Listowsky I. Serum glutathione-S-transferase as a tumor marker for gastrointestinal malignancies. Cancer 1989; 63: 317
   PubMed Web of Science ®Google Scholar
• Tsuchida S., Sekine Y., Shineha R., Nishihira T., Sato K. Elevation of the placental glutathione S-transferase form (GST) in tumor tissues and the levels in sera of patients with cancer. Cancer Res. 1989; 49: 5225
   PubMed Web of Science ®Google Scholar
• Rogerson K. S., Mitchell D., Lawton A., Ibbotson R., Cotton W., Strange R. C. Studies on the glutathione S-transferase of human platelets. Biochem. Biophys. Res. Commun. 1984; 122: 407
   PubMed Web of Science ®Google Scholar
• Howie A. F., Douglas J. G., Fergusson R. J., Beckett G. J. Measurement of glutathione S-transferase pi isoenzyme in plasma, a possible marker for adenocarcinoma of the lung. Clin. Chem. 1990; 36: 453
   PubMed Web of Science ®Google Scholar
• Arrick B. A., Nathan C. F. Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer Res. 1984; 44: 4224
   PubMed Web of Science ®Google Scholar
• Tew K. D., Clapper M. L. Glutathione S-transferases and anticancer drug resistance. Mechanisms of Drug Resistance in Neoplastic Cells, P. V. Woolley, K. D. Tew. Academic Press, New York 1987; 141
   Google Scholar
• Hayes J. D., Wolf C. R. Role of glutathione transferase in drug resistance. Glutathione Conjugation, H. Sies, B. Ketterer. Academic Press, London 1988; 316
   Google Scholar
• Waxman D. J. Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy — a review. Cancer Res. 1990; 50: 6449
   PubMed Web of Science ®Google Scholar
• Dulik D. M., Fenseiau C., Hilton J. Characterization of melphalan-glutathione adducts whose formation is catalyzed by glutathione transferases. Biochem. Pharmacol. 1986; 35: 3405
   PubMed Web of Science ®Google Scholar
• Dulik D. M., Fenseiau C. Conversion of melphalan to 4-(glutathionyl)phenylalanine. A novel mechanism for conjugation by glutathione S-transferases. Drug Metab. Dispos. 1987; 15: 195
   PubMed Web of Science ®Google Scholar
• Dulik D. M., Colvin O. M., Fenseiau C. Characterization of glutathione conjugates of chlorambucil by fast atom bombardment and thermospray liquid chromatography/mass spectrometry. Biomed. Environ. Mass Sped. 1990; 19: 248
   PubMedGoogle Scholar
• Bolton M. G., Benson A., Hantel A., Russo J. E., Colvin O. M., Hilton J. Identification of the glutathione-S-transferase (GST) isoenzyme from mouse liver cytosol responsible for melphalan (LPAM) and glutathione (GSH) conjugation. Proc. Am. Assoc. Cancer Res. 1989; 30: 503
   Google Scholar
• Ciaccio P. J., Tew K. D., LaCreta F. P. The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione. Cancer Commun. 1990; 2: 279
   PubMed Web of Science ®Google Scholar
• Smith M. T., Evans C. G., Doane-Setzer P., Castro V. M., Tahir M. K., Mannervik B. Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells. Cancer Res. 1989; 49: 2621
   PubMed Web of Science ®Google Scholar
• Atsmon J., Freeman M. L., Meredith M. J., Sweetman B. J., Roberts L. J., Jr. Conjugation of 9-deoxy-Δ9, Δ12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. Cancer Res. 1990; 50: 1879
   PubMed Web of Science ®Google Scholar
• Atsmon J., Sweetman B. J., Baertschi S. W., Harris T. M., Roberts L. J., Jr. Formation of thiol conjugates of 9-deoxy-Δ9, Δ12(E)-prostaglandin D2 and Δ12(E)-prostaglandin D2. Biochemistry 1990; 29: 3760
   PubMed Web of Science ®Google Scholar
• Kato T., Fukushima M., Kurozumi S., Noyori T. Antitumor activity of prostaglandin A1 and Δ12-prostaglandin J2in vitro an. in vivo, Cancer Res. 1986; 46: 3538
   PubMed Web of Science ®Google Scholar
• Narumiya S., Ohno K., Fukushima M., Fujiwara M. Site and mechanism of growth inhibition by prostaglandins. III. Distribution and binding of prostaglandin A2 and Δ12-prostaglandin J2 in nuclei. J. Pharmacol. Exp. Ther. 1988; 242: 306
   Web of Science ®Google Scholar
• Benz C. C., Keniry M. A., Ford J. M., Townsend A. J., Cox F. W., Palayoor S., Matlin S. A., Hait W. N., Cowan K. H. Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. Mol. Pharmacol. 1990; 37: 840
   PubMed Web of Science ®Google Scholar
• Wang A. L., Tew K. D. Increased glutathione S-transferase activity in a cell line with acquired resistance to nitrogen mustards. Cancer Treat. Rep. 1985; 69: 677
   PubMedGoogle Scholar
• Manoharan T. H., Puchalski R. B., Burgess J. A., Pickett C. B., Fah J. W. E. Promoter-glutathione-S-transferase Ya cDNA hybrid genes. Expression and conferred resistance to an alkylating molecule in mammalian cells. J. Biol. Chem. 1987; 262: 3739
   PubMed Web of Science ®Google Scholar
• Nakagawa K., Saijo N., Tsuchida S., Sakai M., Tsunokawa Y., Yokota J., Muramatsu M., Sato K., Terada M., Tew K. D. Glutathione-S-transferase as a determinant of drug resistance in transfectant cell lines. J. Biol. Chem. 1990; 265: 4296
   PubMed Web of Science ®Google Scholar
• Miyazaki M., Kohno K., Saburi Y., Matsuo K., Ono M., Kuwano M., Tsuchida S., Sato K., Sakai M., Muramatsu M. Drug resistance to cis-diarriminedichloroplatinum(II) in Chinese hamster ovary cell lines transfected with glutathione S-transferase pi gene. Biochem. Biophys. Res. Commun. 1990; 166: 1358
   PubMed Web of Science ®Google Scholar
• Puchalski R. B., Fahl W. E. Expression of recombinant glutathione S-transferase, Ya1 or Yb1 confers resistance to alkylating agents. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 2443
   PubMed Web of Science ®Google Scholar
• Moscow J. A., Townsend A. J., Cowan K. H. Elevation of °Class glutathione S-transferase activity in human breast cancer cells by transfection of the GST gene and its effect on sensitivity to toxins. Mol. Pharmacol. 1989; 36: 22
   PubMed Web of Science ®Google Scholar
• Leyland-Jones B. R., Townsend A. J., Tu C.-P. D., Cowan K. H., Goldsmith M. E. Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human α class glutathione S-transferase gene. Cancer Res. 1991; 51: 587
   PubMed Web of Science ®Google Scholar
• Fairchild C. R., Moscow J. A., O'Brien E. E., Cowan K. H. Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase. Mol. Pharmacol. 1990; 37: 801
   PubMed Web of Science ®Google Scholar
• Buller A. L., Clapper M. L., Tew K. D. Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines. Mol. Pharmacol. 1987; 31: 575
   PubMed Web of Science ®Google Scholar
• Robson C. N., Lewis A. D., Wolf C. R., Hayes J. D., Hall A., Proctor S. J., Harris A. L., Hickson I. D. Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity. Cancer Res. 1987; 47: 6022
   PubMed Web of Science ®Google Scholar
• Skalski V., Yarosh D. B., Batist G., Gros P., Feindel W., Kopriva D., Panasci L. C. Mechanisms of resistance to (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarCNU) in sensitive and resistant human glioma cells. Mol. Pharmacol. 1990; 38: 299
   PubMed Web of Science ®Google Scholar
• Spitz D. R., Malcolm R. R., Roberts R. J. Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic byproducts of lipid peroxidation contribute to oxidative stress. Biochem. J. 1990; 267: 453
   PubMed Web of Science ®Google Scholar
• Tew K. D. Enzyme changes linked to anticancer drug resistance. Annu. Rep. Med. Chem. 1988; 23: 265
   Web of Science ®Google Scholar
• Hayes J. D., Pickett C. B., Mantle T. J. Glutathione S-transferases and Drug Resistance. Taylor & Francis, London 1990; 1
   Google Scholar
• Kondo T., Kawakami Y., Taniguchi N., Beutler E. Glutathione disulfide-stimulated Mg2+-ATPase of human erythrocyte membranes. Proc. Natl. Acad. Sci. U.S.A. 1987; 84: 7373
   PubMed Web of Science ®Google Scholar
• Inoue M., Akerboom T. P. M., Sies H., Kinne R., Thao T., Arias I. M. Biliary transport of glutathione S-conjugate by rat liver canalicular membrane vesicles. J. Biol. Chem. 1984; 259: 4998
   PubMed Web of Science ®Google Scholar
• Ishikawa T. ATP/Mg2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles. J. Biol. Chem. 1989; 264: 17343
   PubMed Web of Science ®Google Scholar
• Kondo T., Miyamoto K., Gasa S., Taniguchi N., Kawakami Y. Purification and characterization of glutathione disulfide-stimulated Mg2+-ATPase from human erythrocytes. Biochem. Biophys. Res. Commun. 1989; 162: 1
   PubMed Web of Science ®Google Scholar
• Hamada H., Okochi E., Watanabe M., Oh-Hara T., Sugimoto Y., Kawabata H., Tsuruo T. Mr 85,000 membrane protein specifically expressed in adriamycin-resistant human tumor cells. Cancer Res. 1988; 48: 7082
   PubMed Web of Science ®Google Scholar
• Lutzky J., Astor M. B., Taub R. N., Baker M. A., Bhalla K., Gervasoni J. E., Jr., Rosado M., Stewart V., Krishna S., Hindenburg A. A. Role of glutathione and dependent enzymes in anthracycline-resistant HL60/AR cells. Cancer Res. 1989; 49: 4120
   PubMed Web of Science ®Google Scholar
• Seidegård J., Pero R. W., Miller D. G., Beattie E. J. A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer. Carcinogenesis (London) 1986; 7: 751
   PubMed Web of Science ®Google Scholar
• Seidegård J., Pero R. W., Markowitz M. M., Roush G., Miller D. G., Beattie E. J. Isoenzyme(s) of glutathione transferase (class mu) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis (London) 1990; 11: 33
   PubMed Web of Science ®Google Scholar
• Wiencke J. K., Kelsey K. T., Lamela R. A., Toscano W. A., Jr. Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage. Cancer Res. 1990; 50: 1585
   PubMed Web of Science ®Google Scholar
• Peters W. H. M., Kock L., Nagengast F. M., Roelofs H. M. J. Immunodetection with a monoclonal antibody of glutathione S-transferase mu in patients with and without carcinomas. Biochem. Pharmacol. 1990; 39: 591
   PubMed Web of Science ®Google Scholar
• Strange R. C., Matharoo B., Faulder G. C., Jones P., Cotton W., Elder J. B., Deakin M. The human glutathione S-transferases: a case-control study of the incidence of the GST 10 phenotype in patients with adenocarcinoma. Carcinogenesis (London) 1991; 12: 25
   PubMed Web of Science ®Google Scholar
• Rhoads D. M., Zarlengo R. P., Tu C.-P. D. The basic glutathione S-transferases from human livers are products of separate genes. Biochem. Biophys. Res. Commun. 1987; 145: 474
   PubMed Web of Science ®Google Scholar
• Moorghen M., Cairns J., Forrester L. M., Hayes J. D., Hall A., Cattan A. R., Wolf C. R., Harris A. L. Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa. Carcinogenesis (London) 1991; 12: 13
   PubMed Web of Science ®Google Scholar
• Peters W. H. M., Wormskamp N. G. M., Thies E. Expression of glutathione S-transferases in normal gastric mucosa and in gastric tumors. Carcinogenesis (London) 1990; 11: 1593
   PubMed Web of Science ®Google Scholar
• Lafuente A., Giralt M., Cervello I., Pujol F., Mallol J. Glutathione-S-transferase activity in human superficial transitional cell carcinoma of the bladder. Cancer 1990; 65: 2064
   PubMed Web of Science ®Google Scholar
• Lewis A. D., Forrester L. M., Hayes J. D., Wareing C. J., Carmichael J., Harris A. L., Mooghen M., Wolf C. R. Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines. Br. J. Cancer 1989; 60: 327
   PubMed Web of Science ®Google Scholar
• Castro V. M., Söderström M., Carlberg I., Widersten M., Platz A., Mannervik B. Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes. Carcinogenesis (London) 1990; 11: 1569
   PubMed Web of Science ®Google Scholar
• Singh S. V., Ahmad H., Krishan A. Expression of glutathione-related enzymes in human bladder cancer cell lines. Biochem. Pharmacol. 1990; 39: 1817
   PubMed Web of Science ®Google Scholar
• Bellamy W. T., Dalton W. S., Meltzer P., Dorr R. T. Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells. Biochem. Pharmacol. 1989; 38: 787
   PubMed Web of Science ®Google Scholar
• Cole S. P. C., Downes H. F., Mirski S. E. L., Clements D. J. Alterations in glutathione and glutathione-related enzymes in a multidrug-resistant small cell lung cancer cell line. Mol. Pharmacol. 1990; 37: 192
   PubMed Web of Science ®Google Scholar
• Ali-Osman F., Stein D. E., Renwick A. Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines. Cancer Res. 1990; 50: 6976
   PubMed Web of Science ®Google Scholar
• Lewis A. D., Hayes J. D., Wolf C. R. Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects. Carcinogenesis (London) 1988; 9: 1283
   PubMed Web of Science ®Google Scholar
• Gupta V., Singh S. V., Ahmad H., Medh R. D., Awasthi Y. C. Glutathione and glutathione S-transferases in a human plasma cell line resistant to melphalan. Biochem. Pharmacol 1989; 38: 1993
   PubMed Web of Science ®Google Scholar
• Teicher B. A., Holden S. A., Kelley M. J., Shea T. C., Cucchi C. A., Rosowsky A., Henner W. D., Frei E., III. Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II). Cancer Res. 1987; 47: 388
   PubMed Web of Science ®Google Scholar
• Kuroda H., Sugimoto T., Ueda K., Tsuchida S., Horii Y., Inazawa J., Sato K., Sawada T. Different drug sensitivity in two neuroblastoma cell lines established from the same patient before and after chemotherapy. Int. J. Cancer 1991; 47: 732
   PubMed Web of Science ®Google Scholar
• Deffie A. M., Alam T., Seneviratne C., Beenken S. W., Batra J. K., Shea T. C., Henner W. D., Goldenberg G. J. Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia. Cancer Res. 1988; 48: 3595
   PubMed Web of Science ®Google Scholar
• Singh S. V., Nair S., Ahmad H., Awasthi Y. C., Krishan A. Glutathione S-transferases and glutathione peroxidases in doxorubicin-resistant murine leukemic P 388 cells. Biochem. Pharmacol. 1989; 38: 3505
   PubMed Web of Science ®Google Scholar
• Lee F. Y. F., Sciandra J., Siemann D. W. A study of the mechanism of resistance to adriamycin in vivo. Glutathione metabolism, P-glycoprotein expression, and drug transport. Biochem. Pharmacol. 1989; 38: 3697
   PubMed Web of Science ®Google Scholar
• Schisselbauer J. C., Crescimanno M., D'Allessandro N., Clapper M., Toulmond S., Tapiero H., Tew K. D. Glutathione, glutathione S-transferases, and related redox enzymes in adriamycin- resistant cell lines with a multidrug resistant phenotype. Cancer Commun. 1989; 1: 133
   PubMedGoogle Scholar
• Clapper M. L., Tew K. D. Identification of a glutathione S-transferase associated with microsomes of tumor cell resistant to nitrogen mustards. Biochem. Pharmacol. 1989; 38: 1915
   PubMed Web of Science ®Google Scholar
• Evans C. G., Bodell W. J., Tokuda K., Doane-Setzer P., Smith M. T. Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard. Cancer Res. 1987; 47: 2525
   PubMed Web of Science ®Google Scholar
• Kramer R. A., Zakher J., Kim G. Role of the glutathione redox cycle in acquired and de novo multidrug resistance. Science 1988; 241: 694
   PubMed Web of Science ®Google Scholar
• Watabe T., Hakamata Y., Hiratsuka A., Ogura K. A 7-hydroxymethyl sulfate ester as an active metabolite of the carcinogen, 7-hydroxy-methyl[a]anthracene. Carcinogenesis (London) 1986; 7: 207
   PubMed Web of Science ®Google Scholar