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Research Article

Glutathione S-Transferases: Gene Structure and Regulation of Expression

Pages 173-207 | Published online: 26 Sep 2008

References

  • Mannervik B., Danielson U. H. Glutathione S-transferases structure and catalytic activity. CRC Crit. Rev. Biochem. 1988; 23: 283
  • Fahey R. C., Sundquist A. R. Evolution of glutathione metabolism. Adv. Enzymol. 1991; 64: 1
  • Mannervik B. The isoenzymes of glutathione transferase. Adv. Enzymol. 1985; 57: 357
  • Glutathione S-transferases and Carcinogenesis, T. J. Mantle, C. B. Pickett, J. D. Hayes. Taylor and Francis, London 1987
  • Glutathione conjugation: Mechanisms and Biological Significance, H. Sies, B. Ketter. Academic Press, New York 1988
  • Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, T. J. Mantle. Taylor and Francis, London 1990
  • Coles B., Ketterer B. The role of glutathione and glutathione transferases in chemical carcinogenesis. CRC Crit. Rev. Biochem. Mol. Biol. 1990; 25: 47
  • Jakoby W. B., Ziegler D. M. The enzymes of detoxication. J. Biol. Chem. 1990; 265: 20715
  • Listowsky I. Glutathione S-transferases: intracellular binding, detoxification and adaptive responses. Hepatic and Bile Secretion Transport: Physiology and Pathophysiology, N. Tavoloni, P. D. Berk. Raven Press, New York 1993; 397
  • Pickett C. P., Lu A. Y. H. Glutathione S-transferases: gene structure, regulation and biological function. Annu. Rev. Biochem. 1989; 58: 743
  • Kalinyak J. E., Taylor J. M. Rat glutathione S-transferase. Cloning of double-stranded cDNA and induction of its mRNA. J. Biol. Chem. 1982; 257: 523
  • Daniel V., Sarid S., Bar-Nun S., Litwack G. Rat ligand in mRNA molecular cloning and sequencing. Arch. Biochem. Biophys. 1983; 227: 266
  • Taylor J. B., Craig R. K., Beale D., Ketterer B. Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino acid sequence of the rat glutathione transferase Ya subunit. Biochem. J. 1984; 219: 223
  • Lai H. C. J., Li N. Q., Weiss M. J., Reddy C. C., Tu C. P. D. The nucleotide sequence of a rat liver glutathione S-transferase subunit cDNA clone. J. Biol. Chem. 1984; 259: 5536
  • Pickett C. B., Telakowski-Hopkins C. A., Ding G. J. F., Argenbright L., Lu A. Y. H. Rat liver Glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb and Yc mRNAs by 3-methylcholanthrene and phenobarbital. J. Biol. Chem. 1984; 259: 5182
  • Tu C. P. D., Lai H. C. J., Li N. Q., Weiss M. J., Reddy C. C. The Yc and Ya subunits of rat liver glutathione S-transferases are the products of separate genes. J. Biol. Chem. 1984; 259: 9434
  • Telakowski-Hopkins C. A., Rodney J. A., Bennet C. D., Lu A. Y. H., Pickett C. B. Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit. J. Biol. Chem. 1985; 260: 5820
  • Daniel V., Sharon R., Tichauer Y., Sarid S. Mouse glutathione S-transferase Ya subunit: gene structure and sequence. DNA 1987; 6: 317
  • Gardlik S., Gasser R., Philpot R. M., Serabjit-Singh C. J. The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression and regulation. J. Biol. Chem. 1991; 266: 19681
  • Tu C. P. D., Matsushima A., Li N. Q., Rhoads D. M., Srikumar K., Reddy A. P., Reddy C. C. Immunological and sequence interrelationships between multiple human liver and rat glutathione S-transferases. J. Biol. Chem. 1986; 261: 9540
  • Tu C. P. D., Qian B. Human liver glutathione S-transferases: complete primary sequence of an Ha subunit cDNA. Biochim. Biophys. Res. Commun. 1986; 141: 229
  • Board P. G., Webb G. C. Isolation of a cDNA clone and localization of human glutathione S-transferase 2 genes to chromosomes band 6pl2. Proc. Natl. Acad. Sci. U.S.A. 1987; 84: 2377
  • Hayes J. D., Kerr L. A., Cronshaw A. D. Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Biochem. J. 1989; 264: 437
  • Rhoads D. M., Zarlengo R. P., Tu C. P. D. The basic glutathione S-transferases from human livers are products of separate genes. Biochem. Biophys. Res. Commun. 1987; 145: 474
  • Czosnek H., Sand S., Barker P. E., Ruddle F. H., Daniel V. Glutathione S-transferase Ya subunit is coded by a multigene family located on a single mouse chromosome. Nucleic Acids Res. 1984; 12: 4825
  • Kingsley D. M., Jenkins N. A., Copeland N. G. A molecular genetic linkage map of mouse chromosome 9 with regional localizations for the Gsta, T3g, Ets-1 and Ldlr loci. Genetics 1989; 123: 165
  • Masanori K., Matsumura E., Webb G., Board P. G., Figueroa F., Klein J. Mapping of class alpha glutathione S-transferase 2 (Gst-2) genes to the vicinity of the d locus on mouse chromosome 9. Genomics 1990; 8: 90
  • Rothkopf G. S., Telakowski-Hopkins C. A., Stotish R. L., Pickett C. B. Multiplicity of glutathione S-transferase genes in rat and association with a type 2 Alu repetitive element. Biochemistry 1986; 25: 993
  • Telakowski-Hopkins C. A., Rothkopf G. S., Pickett C. B. Structure analysis of a rat liver glutathione S-transferase Ya gene. Proc. Natl. Acad. Sci. USA. 1986; 83: 9393
  • Daniel V., Sharon R., Tichauer Y., Sarid S. (1987) Mouse glutathione S-transferase Ya subunit: gene structure and sequence. Regulation of Liver Gene Expression Meeting. 1987. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 41
  • Rozen F., Nguyen T., Pickett C. B. Isolation and characterization of a human glutathione S-transferase Ha1 subunit gene. Arch. Biochem. Biophys. 1992; 292: 589
  • Telakowski-Hopkins C. A., King R. G., Pickett C. B. Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression. Proc. Natl. Acad. Sci. USA. 1988; 85: 1000
  • Daniel V., Tichauer Y., Sharon R. 5 flanking sequence of mouse glutathione S-transferase Ya gene. Nucleic Acids Res. 1988; 16: 351
  • Daniel V., Sharon R., Bensimon A. Regulatory elements controlling the basal and drug-inducible expression of glutathione S-transferase Ya subunit gene. DNA 1989; 8: 399
  • Ding G. J.-F., Lu A. Y. H., Pickett C. B. Rat liver glutathione S-transferases. Nucleotide sequence analysis of a Yb1, cDNA clone and prediction of the complete amino acid sequence of the Yb1 subunit. J. Biol. Chem. 1985; 260: 13268
  • Ding G. J.-F., Ding V. D.-H., Rodkey J. A., Bennett C. D., Lu A. Y. H., Pickett C. B. DNA sequence analysis of a Yb2 DNA clone and regulation of the Yb1 and Yb2 mRNAs by phenobarbital. J. Biol. Chem. 1986; 261: 7952
  • Lai H. C. J., Grove G., Tu C. P. D. Cloning and sequence analysis of a cDNA for a rat liver glutathione S-transferase Yb subunit. Nucleic Acids Res. 1986; 14: 6101
  • Lai H. C. J., Tu C. P. D. Rat glutathione S-transferases supergene family. Characterization of an anionic Yb subunit cDNA clone. J. Biol. Chem. 1986; 261: 13793
  • Lai H. C. J., Qian B., Grove G., Tu C. P. D. Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family. J. Biol. Chem. 1988; 263: 11389
  • Morton M. R., Bayney R. M., Pickett C. B. Isolation and characterization of the rat glutathione S-transferase Ybl subunit gene. Arch. Biochem. Biophys. 1990; 211: 56
  • Abramovitz M., Listowsky I. Selective expression of a unique glutathione S-transferase Yb3 gene in rat brain. J. Biol. Chem. 1987; 262: 7770
  • Baltimore D. Gene conversion: some implications for immunoglobulin genes. Cell 1981; 24: 592
  • Taylor J. B., Oliver J., Sherrington R., Pemble S. E. Structure of human glutathione S-transferase class Mu genes. Biochem. J. 1991; 274: 587
  • Board P. G. Biochemical genetics of glutathione S-transferase. Am. J. Hum. Genet. 1981; 33: 36
  • Board P. G. Gene deletion and partial deficiency of the glutathione S-transferase (ligandin) system in man. FEBS Lett. 1981; 135: 12
  • Suzuki T., Coggan M., Shaw D. C., Board P. G. Electrophoretic and immunological analysis of human glutathione S-transferase isozymes. Ann. Hum. Genet. 1987; 51: 95
  • Seidegard J., Guthenberg C., Piro R. W., Mannervik B. The trans-stilbene oxide-active glutathione transferase in human mononuclear leukocytes is identical with the hepatic glutathione transferase μ. Biochem. J. 1987; 246: 783
  • Board P. G., Suzuki T., Shaw D. C. Human muscle glutathione S-transferase (GST-4) shows close homology to human liver GST-1. Biochim. Biophys. Acta 1988; 953: 214
  • Mannervik B., Awasthi Y. C., Board P. G., Hayes J. D., Di Ilio C., Ketterer B., Listowsky I., Morgernstern R., Muramatsu M., Pearson W. R., Pickett C. B., Sato K., Wildersten M., Wolf R. C. Nomenclature of human glutathione transferases. Biochem. J. 1992; 282: 305
  • Seidegård J., Pero R. W. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes. Hum. Genet. 1985; 69: 66
  • Seidegård J., Pero R. W., Miller D. G., Beattie E. J. A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer. Carcinogenesis 1986; 7: 751
  • Seidegård J., Pero R. W., Markowitz M. M., Roush G., Miller D. G., Beattie E. J. Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis 1990; 11: 33
  • Seidegard J., Vorachek W. R., Pero R. W., Pearson W. R. Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl. Acad. Sci. USA. 1988; 85: 7293
  • De Jong J. L., Chang C. M., Whang-Peng J., Knutsen T., Tu C. P. D. The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA. Nucleic Acids Res. 1988; 16: 8541
  • Singh S. V., Kurosky A., Awasthi Y. C. Human liver glutathione S-transferase. Biochem. J. 1987; 243: 61
  • De Jong J. L., Mohandas T., Tu C. P. D. The human Hb (Mu) class glutathione S-transferases are encoded by a dispersed gene family. Biochem. Biophys. Res. Commun. 1991; 180: 15
  • Vorachek W. R., Pearson W. R., Rule G. S. Cloning, expression and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus. Proc. Natl. Acad. Sci. USA. 1991; 88: 4443
  • Campbell E., Takahashi Y., Abramovitz M., Perez M., Listowsky I. A distinct human testis and brain class mu glutathione S-transferase. Molecular cloning and characterization of a form present in individuals lacking hepatic type isoenzymes. J. Biol. Chem. 1990; 265: 9188
  • Suguoka Y., Kano T., Okuda A., Sakai M., Kitagawa T., Muramatsu M. Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA. Nucleic Acids Res. 1985; 13: 6049
  • Pemble S. E., Taylor J. B., Ketterer B. Tissue distribution of rat glutathione transferase subunit 7, a hepatoma marker. Biochem. J. 1986; 240: 885
  • Kano T., Sakai M., Muramatsu M. Structure and expression of a human glutathione S-transferase messenger RNA. Cancer Res. 1987; 47: 5626
  • Okuda A., Sakai M., Muramatsu M. The structure of the rat glutathione S-transferase P gene and related pseudogenes. J. Biol. Chem. 1987; 262: 3858
  • Cowell L. C., Dixon K. H., Pemble S. E., Ketterer B., Taylor J. B. The structure of the human glutathione S-transferase gene. Biochem. J. 1988; 255: 79
  • De Jong J. L., Morgenstern R., Jörnvall H., De Pierre J. W., Tu C. P., D. Gene expression of rat and human microsomal glutathione S-transferases. J. Biol. Chem. 1988; 263: 8430
  • Morgenstern R., De Pierre J. W., Jörnvall H. Microsomal glutathione transferase: primary structure. J. Biol. Chem. 1985; 260: 13976
  • De Jong J. L., Mohandas T., Tu C. P. D. The gene for the microsomal glutathione S-transferase is on human chromosome 12. Genomics 1990; 6: 379
  • Hales B. F., Neims A. Induction of hepatic glutathione transferase B by phenobarbital and 3-methylcholanthrene. Biochem. Pharmacol. 1977; 26: 555
  • Benson A. M., Batzinger R. P., Ou S. Y. L., Bueding E., Cha Y. N., Talalay P. Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo[α]pyrene by dietary antioxidants. Cancer Res. 1978; 38: 4486
  • Benson A. M., Cha Y. N., Bueding E., Heine H. S., Talalay P. Elevation of extrahepatic glutathione S-transferases and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole. Cancer Res. 1979; 39: 2971
  • Sparnins V. L., Wattenberg L. W. Enhancement of glutathione S-transferase activity of the mouse forestomach by inhibitors of benzo[α]pyrene-induced neoplasia of the forestomach. J. Natl. Cancer Inst. 1981; 66: 769
  • Sparnins V. L., Venegas P. L., Wattenberg L. W. Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents. J. Natl. Cancer Inst. 1982; 68: 493
  • Pickett C. B., Wells W., Lu A. Y. H., Hales B. F. Induction of translationally active rat liver glutathione S-transferase B messenger RNA by phenobarbital. Biochem. Biophys. Res. Commun. 1981; 99: 1002
  • Pickett C. B., Telakowski-Hopkins C. A., Donohue A. M., Lu A. Y. H., Hales B. F. Differential induction of rat hepatic cytochrome P-448 and glutathione S-transferase B messenger RNAs by methyl-cholanthrene. Biochem. Biophys. Res. Commun. 1982; 104: 611
  • Pickett C. B., Donohue A. M., Lu A. Y. H., Hales B. F. Rat liver glutathione S-transferase B. The functional mRNAs specific for the Ya Yc sub-units are induced differentially by phenobarbital. Arch. Biochem. Biophys. 1982; 215: 539
  • Pearson W. R., Windle J. J., Morrow J. F., Benson A. M., Talalay P. Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA. J. Biol. Chem. 1983; 258: 2052
  • Pickett C. B., Telakowski-Hopkins C. A., Ding G. J.-F., Argenbright L., Lu A. Y. H. Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb and Yc mRNAs by 3-methylcholanthrene and phenobarbital. J. Biol. Chem. 1984; 259: 5182
  • Ding V. D.-H., Pickett C. B. Transcriptional regulation of rat liver glutathione S-transferase genes by phenobarbital and 3-methylcholanthrene. Arch. Biochem, Biophys. 1985; 240: 553
  • Pearson W. R., Reinhart J., Sisk S. C., Anderson K. S., Adler P. N. Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole. J. Biol. Chem. 1988; 263: 13324
  • Di Simplicio P., Jensson H., Mannervik B. Effects of inducers of drug metabolism on basic hepatic forms of mouse glutathione transferase. Biochem. J. 1989; 263: 679
  • Hayes J. D., Kerr L. A., Peacock S. D., Cronshaw A. D., McLellan L. I. Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Biochem. J. 1991; 277: 501
  • Hayes J. D., Judah D. J., McLellan L. I., Kerr L. A., Peacock S. D., Neal G. E. Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel Alpha-class glutathione S-transferase sub-unit Yc2 which possesses high catalytic activity for aflatoxin B1-8,9-epoxide. Biochem. J. 1991; 279: 385
  • Williams R. T. Comparative patterns of drug metabolism. Fed. Proc 1967; 26: 1029
  • Wattenberg L. W. Chemoprevention of cancer. Cancer Res. 1985; 45: 1
  • Talalay P., De Long M. J., Prochaska H. J. Molecular mechanisms in protection against carcinogenesis. Cancer Biology and Therapeutics, J. G. Cory, A. Szentivanyi. Plenum. 1987; 197
  • Prochaska H. J., Santamaria A. B., Talalay P. Rapid detection of inducers of enzymes that protect against carcinogens. Proc. Natl. Acad. Sci. USA. 1992; 89: 2394
  • Zhang Y., Talalay P., Cho C. G., Posner G. H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. U.S.A. 1992; 89: 2399
  • Nebert D. W., Gonzalez F. J. P450 genes: structure, evolution and regulation. Annu. Rev. Biochem. 1987; 56: 945
  • Nebert D. W., Jones J. E. Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene. Int. J. Biochem. 1989; 21: 243
  • Whitlock J. P. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu. Rev. Pharmacol. Toxicol. 1990; 30: 251
  • Landers J. P., Bunce N. J. Review article. The Ah receptor and the mechanism of dioxin toxicity. Biochem. J. 1991; 276: 273
  • Denison M. S., Fisher J. M., Whitlock J. P., Jr. The DNA recognition site for the dioxin-Ah receptor complex: nucleotide sequence and functional analysis. J. Biol. Chem. 1988; 263: 17221
  • Fujisawa-Sehara A., Yamane M., Fujii-Kuriyama Y. A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as cryptic forms in cytoplasm: Its possible translocation to nucleus. Proc. Natl. Acad. Sci. USA. 1988; 85: 5859
  • Owens I. S. Genetic regulation of UDP-glucuronosyl transferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo[α]pyrene) hydrolase induction. J. Biol. Chem. 1977; 252: 2827
  • Felton J. S., Ketley J. N., Jakoby W. B., Aitio A., Bend J. R., Nebert D. W. Hepatic glutathione transferase activity induced by polycyclic aromatic compounds. Lack of correlation with the murine Ah locus. Mol. Pharmacol. 1980; 18: 559
  • Bigelow S. W., Nebert D. W. The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines. J. Biochem. Toxicol. 1986; 1: 1
  • Prochaska H. J., De Long M. J., Talalay P. On the mechanism of induction of cancer protective enzymes: a unifying proposal. Proc. Natl. Acad. Sci. USA. 1985; 82: 8232
  • Prochaska H. J., Talalay P. Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver. Cancer Res. 1988; 48: 4776
  • De Long M. I., Santamaria A. B., Talalay P. Role of cytochrome P1-450 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants. Carcinogenesis 1987; 8: 1549
  • Miller A. G., Israel D., Whitlock J. P., Jr. Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo (a) pyrene-metabolizing enzyme, activity. J. Biol. Chem. 1983; 258: 3523
  • Israel D. I., Whitlock J. B., Jr. Regulation of cytochrome P1-450 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells. J. Biol. Chem. 1984; 259: 5400
  • Kimura S., Smith H. H., Hankinson O., Nebert D. W. Analysis of two benzo[α]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P1450 gene via cDNA expression in yeast. EMBO J. 1929; 6: 1987
  • Friling R. S., Bensimon A., Tichauer Y., Daniel V. Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element. Proc. Natl. Acad. Sci. USA. 1990; 87: 6258
  • Rushmore T. H., Pickett C. B. Transcriptional regulation of the rat glutathione S-transferase Ya sub-unit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. J. Biol. Chem. 1990; 265: 14648
  • Poland A., Knutson J. C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol 1982; 22: 517
  • Talalay P., De Long M. J., Prochaska H. J. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 8261
  • Spencer S. R., Xue L., Klenz E. M., Talalay P. The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Biochem. J. 1991; 273: 711
  • Deschatrette J., Weiss M. C. Characterization of differentiated and dedifferentiated clones from a rat hepatoma. Biochimie 1974; 56: 1603
  • Wiebel F. J., Park S. S., Kiefer F., Gelboin H. V. Expression of cytochromes P1-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P1-450 from rat liver induced by 3-methylcholanthrene or phenobarbital. Eur. J. Biochem. 1984; 145: 455
  • Bensimon A. Ph.D. thesis, Feinberg Graduate School, Weizmann Institute of Science, Rehovot 1992
  • Pinkus R. M.Sc. thesis, Feinberg Graduate School, Weizmann Institute of Science, Rehovot 1992
  • Rushmore T. H., King R. G., Paulson E. K., Pickett C. B. Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc. Natl. Acad. Sci. USA. 1990; 87: 3826
  • Rushmore T. H., Morton M. R., Pickett C. B. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J. Biol. Chem. 1991; 266: 11632
  • Paulson E. K., Darnell J. E., Jr., Rushmore T. H., Pickett C. B. Analysis of the upstream elements of the xenobiotic compound-inducible and position-ally regulated glutathione S-transferase Ya gene. Mol. Cell. Biol. 1990; 10: 1841
  • Courtois G., Morgan J. G., Cambell L. A., Fourel G., Crabtree G. R. Interaction of liver-specific nuclear factor with the fibrinogen and α-1 antitrypsin promoters. Science 1987; 238: 688
  • Hardon E. M., Frain M., Paonessa G., Cortese R. Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J. 1988; 7: 1711
  • Cereghini S., Blumenfeld M., Yaniv M. A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cell. Genes Dev. 1988; 2: 957
  • Costa R. H., Grayson D. R., Darnel J. E., Jr. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α1-antitrypsin genes. Mol. Cell. Biol. 1989; 9: 1415
  • Cereghini S., Raymondjean M., Carranca A. G., Hebomel P., Yaniv M. Factors involved in control of tissue-specific expression of albumin gene. Cell 1987; 50: 627
  • Maire P., Wuarin J., Schibler U. The role of cis-acting promoter elements in tissue-specific albumin gene expression. Science 1989; 244: 343
  • Friling R. S., Bergelson S., Daniel V. Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene. Proc. Natl. Acad. Sci. U.S.A. 1992; 89: 668
  • Lee W., Haslinger A., Karin M., Tijan R. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature (London) 1987; 325: 368
  • Angel P., Imagawa M., Chiu R., Stein B., Imbra R. J., Rahmsdorf H. J., Jonat C., Herrlich P., Karin M. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 1987; 49: 729
  • Angel P., Bauman I., Stein B., Delius H., Rahmsdorf H. J., Herrlich P. 12-0-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5-flanking region. Mol. Cell. Biol. 1987; 7: 2256
  • Curran T., Franza R. B., Jr. Fos and Jun: the AP-1 connection. Cell 1988; 55: 395
  • Kryszke M. H., Piette J., Yaniv M. Induction of a factor that binds to the polyoma virus A enhancer on differentiation of embryonal carcinoma cells. Nature 1987; 328: 254
  • Chiu R., Angel P., Karin M. Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell 1989; 59: 979
  • Sato K., Kitahara A., Satoh K., Ishikawa T., Tatematsu M., Ito N. The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Jpn. J. Cancer Res. (Gann) 1984; 75: 199
  • Kitahara A., Satoh K., Nishimura K., Ishikawa T., Ruike K., Sato K., Tsuda H., Ito N. Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis. Cancer Res. 1984; 44: 2698
  • Satoh K., Kitahara A., Soma Y., Inaba Y., Hatayama I., Sato K. Purification, induction and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 1985; 82: 3964
  • Sugioka Y., Fujii-Kuriyama Y., Kitagawa T., Muramatsu M. Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis. Cancer Res. 1985; 45: 365
  • Sato K. Glutathione transferases as markers of preneoplasia and neoplasia. Adv. Cancer Res. 1989; 52: 205
  • Wolf C. R., Warsing C. J., Black S. M., Hayes J. D. Glutathione S-transferases in resistance to chemotherapeutic drugs. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, M. Y. Mantle. Taylor and Francis. 1989; 295
  • Tew K. D., Schisselbauer J. C., Clapper M. L., Kuzmich S. Glutathione S-transferase and resistance to alkylating agents. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, M. Y. Mantle. Taylor and Francis. 1989; 309
  • Moscow J. A., Fairchild C. R., Townsend A. J., Cowan K. W. Glutathione S-transferase Pi and antineoplastic drug resistance. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, M. Y. Mantle. Taylor and Francis. 1989; 319
  • Moscow J. A., Townsend A. J., Cowan K. H. Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST. gene and its effect on the sensitivity to toxins. Mol. Pharmacol. 1989; 36: 22
  • Power C., Sinha S., Webber C., Manson M. M., Neal G. E. Transformation related expression of glutathione-S-transferase P in rat liver cells. Carcinogenesis 1987; 8: 797
  • Sato K., Satoh K., Tsuchida S., Hatayama I., Tamai K., Shere H. Glutathione S-transferases and (pre) neoplasia. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, M. Y. Mantle. Taylor and Francis. 1989; 329
  • Sakai M., Okuda A., Nishi S., Muramatsu M. Regulation of glutathione transferase P (GST-P) gene expression during chemical hepatocarcinogenesis. Isozymes: Structure, Function and Use in Biology and Medicine. Wiley-Liss. 1990; 123
  • Burt R. K., Garfield S., Johnson K., Thorgeirsson S. S. Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione S-transferase-P and increased resistance to cytotoxic chemicals. Carcinogenesis 1988; 9: 2329
  • Li Y., Seyama T., Godwin A. K., Winokur T. S., Lebovitz R. M., Lieberman M. W. MTras T24, a metallothioneine-ras fusion gene, modulates expression in cultured rat liver cells of two genes associated with in vivo liver cancer. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 344
  • Abramovitz M., Listowsky I. Developmental regulation of glutathione S-transferases. Xenobiotica 1988; 18: 1249
  • Pemble S. E., Taylor J. B., Ketterer B. Tissue distribution of rat glutathione S-transferase subunit 7 hepatoma marker. Biochem. J. 1986; 240: 885
  • Dock L. Induction of rat liver glutathione transferase isoenzyme 7–7 by lead nitrate. Biol. Trace Elem. Res. 1989; 21: 283
  • Vandenberghe Y., Glaise D., Meyer D. J., Guillouzo A., Ketterer B. Glutathione transferase isoenzymes in cultured rat hepatocytes. Biochem. Pharmacol. 1988; 37: 2482
  • Vandenberghe Y., Morel F., Foriers A., Ketterer B., Vercruysee A., Guillouzo A., Rogiers V. Effect of phenobarbital on the expression of glutathione S-transferase isoenzyme in cultured rat hepatocytes. FEBS Lett. 1989; 251: 59
  • Abramovitz H., Ishigaki S., Listowsky I. Differential regulation of glutathione S-transferases in cultured hepatocytes. Hepatology 1989; 9: 235
  • Gebhardt R., Fitzke H., Fausel M., Eisenmann-Tappe I., Mecke D. Influence of hormones and drugs on glutathione S-transferase levels in primary culture of adult rat hepatocytes. Cell Biol. Toxicol. 1990; 6: 365
  • Hatayama I., Yamada Y., Tanaka K., Ichihara A., Sato K. Induction of glutathione S-transferase P-form in primary cultured rat hepatocytes by epidermal growth factor and insulin. Jpn. J. Cancer Res. 1991; 82: 807
  • Sakai M., Okuda A., Hatayama I., Sato K., Nishi S., Muramatsu M. Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis. Cancer Res. 1989; 49: 5633
  • Sakai M., Okuda A., Muramatsu M. Multiple regulatory elements and phorbol 12-0-tetradecanoate 13-acetate responsiveness of the rat placental glutathione transferase gene. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 9456
  • Muramatsu M., Okuda A., Imagawa M., Sakai M. Regulation of glutathione transferase P gene during hepatocarcinogenesis of the rat. Glutathione S-transferases and Drug Resistance, J. D. Hayes, C. B. Pickett, M. Y. Mantle. Taylor and Francis. 1989; 165
  • Okuda A., Imagawa M., Maeda Y., Sakai M., Muramatsu M. Structural and functional analysis of enhancer GPEI having a phorbol-12–0-tetra decanoate 13-acetate responsive element-like sequence found in the rat glutathione transferase P gene. J. Biol. Chem. 1989; 264: 16919
  • Okuda A., Imagawa M., Sakai M., Muramatsu M. Functional cooperativity between two TPA responsive elements in undifferentiated F9 embryonic stem cell. EMBO J. 1990; 9: 1131
  • Imagawa M., Osada S., Okuda A., Muramatsu M. Silencer binding proteins function on multiple cis-elements in the glutathione transferase P gene. Nucleic Acids Res. 1991; 19: 5
  • Imagawa M., Osada S., Koyama Y., Suzuki T., Hirom P. C., Diccianni M. B., Morimura S., Muramatsu M. SF-B that binds to a negative element in glutathione transferase P gene is similar or identical to trans-activator LAP/IL6-DBP. Biochem. Biophys. Res. Comm. 1991; 179: 293
  • Morrow C. S., Cowan K. H., Goldsmith M. E. Structure of the human genomic glutathione S-trans-ferase gene. Gene 1989; 75: 3
  • Dixon K. H., Cowell I. G., Xia C. L., Pemble S. E., Ketterer B., Taylor J. B. Control of expression of the human glutathione S-transferase gene differs from its rat orthologue. Biochem. Biophys. Res. Comm. 1989; 163: 815
  • Morrow C. S., Goldsmith M. E., Cowan K. H. Regulation of human glutathione S-transferase gene transcription: influence of 5-flanking sequences and trans-activating factors which recognize AP-1 binding sites. Gene 1990; 88: 215
  • Xia C. L., Cowell I. G., Dixon K. H., Pemble S. E., Ketterer B., Taylor J. B. Glutathione transferase its minimal promoter and downstream cis-acting element. Biochem. Biophys. Res. Comm. 1991; 176: 233
  • Batist G., Tulpule A., Sinha B. K., Katki A. G., Myers C. E., Cowan K. H. Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J. Biol. Chem. 1986; 261: 15544
  • Curran T. The fos oncogene. The Oncogene Handbook, E. P. Reddy, A. M. Skalka, T. Curran. Elsevier Science, Amsterdam 1988; 307
  • Lau L. F., Nathans D. Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc. Natl. Acad. Sci. U.S.A. 1987; 84: 1182
  • Ryseck R. P., Hirai S. I., Yaniv M., Bravo R. Transcriptional activation of c-jun during the Go/G1 transition in mouse fibroblasts. Nature 1988; 344: 535
  • Quantin R., Breatnach R. Epidermal growth factor stimulates transcription of the c-jun protooncogene in rat fibroblasts. Nature 1988; 334: 538
  • Cohen D. R., Curran T. The structure and function of the fos protooncogene. Crit. Rev. Oncogen. 1989; 1: 65
  • Morgan J. I., Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible protooncogenes fos and jun. Annu. Rev. Neurosci. 1991; 14: 421
  • Angel P., Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta. 1991; 1072: 129
  • Landschulz W. M., Johnson P. F., McKnight S. L. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 1988; 240: 1759
  • Nakabeppu Y., Ryder K., Nathans D. DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell 1988; 55: 907
  • Hirai S. L, Ryseck R. P., Mechta F., Bravo T., Yaniv M. Characterization of jun D: a new member of the jun proto-oncogene family. EMBO J. 1989; 8: 1433
  • Zerial M., Toschi L., Ryseck R. P., Schuermann M., Müller R., Bravo R. The product of a novel growth factor activated gene, fos B, interacts with Jun proteins enhancing their DNA binding activity. EMBO J. 1989; 8: 805
  • Cohen D. R., Ferreira P. C. P., Gentz R., Franza B. R., Jr., Curran T. The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev. 1989; 3: 173
  • Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene 1990; 5: 249
  • Hirai S. I., Yaniv M. Jun DNA-binding is modulated by mutations between the leucines or by direct interaction of Fos with the TGACTCA sequence. New Biol. 1989; 181
  • Chiu R., Boyle W., Meek J., Smeal T., Hunter T., Karin M. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 1988; 54: 541
  • Rauscher F., III, Voulalas P., Franza B. R., Jr., Curran T. Fos and Jun bind cooperatively to the AP-1 site: reconstitution. in vitro. Genes Dev. 1988; 2: 1687
  • Sassone-Corsi P., Ransone L. J., Lamph W. W., Verma I. M. Direct interaction between fos and nuclear oncoproteins: role of the “leucine zipper” domain. Nature 1988; 336: 692
  • Kouzarides T., Ziff E. The role of the leucine zipper in the fos-jun interaction. Nature 1988; 336: 646
  • Halazonetis T. D., Georgopoulos K., Greenberg M., Leder P. c-Jun dimerizes with itself and with c-Fos forming complexes of different DNA binding affinities. Cell 1988; 55: 917
  • Lee W., Mitchell P., Tijan R. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 1987; 49: 741
  • Piette J., Yaniv M. Two different factors bind to the α-domain of the polyoma virus enhancer, one of which also interacts with the SV-40 and c-fos enhancers. EMBO J. 1987; 6: 1331
  • Imbra R. J., Karin M. Metallothionein gene expression is regulated by serum factors and activators of protein kinase C. Mol. Cell. Biol. 1987; 7: 1358
  • Franza B. R., Jr., Rauscher F. J., III, Josephs S. F., Curran T. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 1988; 239: 1150
  • Rauscher J. F., III, Sambucetti L. C., Curran T., Distel R. J., Spiegelman B. M. A common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell 1988; 52: 471
  • Greenberg M. E., Greene L. A., Ziff E. B. Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC 12 cells. J. Biol. Chem. 1985; 260: 14101
  • Bravo R. Growth-factor responsive genes in fibroblasts. Cell Growth and Differentiation 1990; 1: 305
  • Angel P., Pöting A., Mallick U., Rahmsdorf H., Schorpp M., Herrlich P. Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblast. Mol. Cell. Biol 1986; 6: 1760
  • Shibanuma M., Kuroki T., Nose K. Inhibition of proto-oncogene c-fos transcription by inhibitors of protein kinase C and ion transport. Eur. J. Biochem. 1987; 164: 15
  • Bravo R., Burchardt J., Curran T., Müller R. Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes. EMBO J. 1985; 4: 1193
  • Curran T., Morgan J. I. Barium modulates c-fos expression and posttranslational modification. Proc. Natl. Acad. Sci. U.S.A. 1986; 83: 8521
  • Morgan J. I., Curran T. Role of ion flux in the control of c-fos expression. Nature 1986; 322: 552
  • Andrews G. K., Harding M. A., Calvet J. B., Adamson E. D. The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene. Mol. Cell Biol. 1987; 7: 3452
  • Sonnenberg J. L., Macgregor-Leon P. F., Curran T., Morgan J. I. Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron 1989; 3: 359
  • Greenberg M. E., Ziff E. B., Greene L. A. Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. Science 1986; 234: 80
  • Devary Y., Gottlieb R. A., Lau L. F., Karin M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell Biol. 1991; 11: 2804
  • Nose K., Shibanuma M., Kikuchi K., Kageyama H., Sakiyama S., Kuroki T. Transcriptional activation of early-response genes by hydroxy peroxide in a mouse osteoblastic cell line. Eur. J. Biochem. 1991; 201: 99
  • Stein B., Rahmsdorf H. J., Steffen A., Liftin M., Herrlich P. UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos and metallothionein. Mol. Cell Biol 1989; 9: 5169
  • Sherman M. L., Datta R., Hallahan D. E., Weichselbaum R. R., Kufe D. W. Ionizing radiation regulates expression of the c-jun proto-oncogene. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 5663
  • Imler J. L., Schatz C., Wasylyk C., Chatton B., Wasylyk B. A Harvery-ras responsive transcription element is also responsive to a tumor-promoter and to serum. Nature 1988; 332: 275
  • Piette J., Hirai S. I., Yaniv M. Constitutive synthesis of activator protein-1 transcription factor after viral transformation of mouse fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 3401
  • Schönthal A., Herrlich P., Rahmsdorf H. J., Ponta H. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 1988; 54: 325
  • Wasylyk C., Imler J. L., Wasylyk B. Transforming but not immortalizing oncogenes activate the transcription factor PEA1. EMBO J. 1988; 7: 2475
  • Pinkus R., Bergelson S., Daniel V. Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression. Biochem. J. 1993; 290: 637
  • Daniel V., Bergelson S., Pinkus R. The role of AP-1 transcription factor in the regulation of glutathione S-transferase Ya subunit gene expression by chemical agents. Structure and Function of Glutathione S-Transferases, K. D. Tew, C. B. Pickett, T. J. Mantle, B. Mannervik, J. Hayes. CRC Press, Boca Raton, FL 1993, (in press)
  • Puga A., Nebert D. W., Carrier F. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. DNA and Cell Biol. 1992; 11: 269
  • Herrlich P., Ponta H. Nuclear oncogenes convert extracellular stimuli into changes in the genetic program. Trend Genet. 1989; 5: 112
  • Kruijer W., Skelly H., Botteri F., Putten H., Barber J. R., Verma I. M., Leffert H. L. Proto-oncogene expression in regenerating liver is stimulated in cultures of primary adult rat hepatocyte. J. Biol. Chem. 1986; 261: 7929
  • Taub R., Roy A., Dieter R., Koontz J. Insulin as a growth factor in rat hepatoma cells. Stimulation of protooncogene expression. J. Biol. Chem. 1987; 262: 10893
  • Stumpo D. J., Stewart T. N., Gilman M. Z., Blackshear P. J. Identification of c-fos sequences involved in induction by insulin and phorbol esters. J. Biol. Chem. 1988; 263: 1611
  • Diamond M. I., Miner J. N., Yoshinaga S. K., Yamamoto K. R. Transcription factor interactions. Selectors of positive or negative regulation from a single DNA element. Science 1990; 249: 1266
  • Schüle R., Rangarajan P., Kliewer S., Ransone L. J., Bolado J., Yang N., Verma I. M., Evans R. M. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 1990; 62: 1217
  • Yang-Yen H. F., Chambard J. C, Sun Y. L., Smeal T., Schmidt T. J., Drouin J., Karin M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990; 62: 1205
  • Jonat C., Rahmsdorf H. J., Park K. K., Cato A. C. B., Gebel S., Ponta H., Herrlich P. Antitumor promotion and antiinflamation: downmodulation of AP-(Fos/Jun) activity by glucocorticoid hormone. Cell 1990; 62: 1189
  • Favreau L. V., Pickett C. B. Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants. J. Biol. Chem. 1991; 266: 4556
  • Baeuerle P. A., Baltimore D. Molecular Aspects of Cellular Regulation. Hormonal Control Regulation of Gene Transcription, P. Cohen, J. G. Foulkes. Elsevier/North Holland Biomedical Press, Amsterdam 1991; 409
  • Nishizuka Y. Studies and perspectives of protein kinase C. Science 1986; 233: 305
  • Curran T., Miller A. D., Zokas L., Verma I. M. Viral and cellular fos proteins: a comparative analysis. Cell 1984; 36: 259
  • Barber J. R., Verma I. M. Modification of fos proteins: phosphorylation of c-fos but not v-fos, is stimulated by 12-0-tetradecanoyl-phorbol-13-acetate and serum. Mol. Cell Biol. 1987; 7: 2201
  • Müller R., Bravo R., Müller D., Kury C., Renz M. Different types of modification in c-fos and its associated protein p39: modification of DNA binding by phosphorylation. Oncogene Res. 1987; 2: 19
  • Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett J. R., Karin M., Hunter T. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 1991; 64: 573
  • Shibanuma M., Kuroki T., Nose K. Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells. Oncogene 1990; 5: 1025
  • Crawford D., Zbinden I., Amstad P., Cerutti P. Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells. Oncogene 1988; 3: 27
  • Shibanuma M., Kuroki T., Nose K. Induction of DNA replication and expression of proto-oncogene c-myc and c-fos in quiescent Balb/3T3 cells by xanthine/xanthine oxidase. Oncogene 1988; 3: 17
  • Fridovich I. The Biology of oxygen radicals. The superoxide radical is an agent of oxygen toxicity; superoxide dismutase provides an important defense. Science 1978; 201: 875
  • Sies H. Oxidative stress: from basic research to clinical application. Am. J. Med. 1991; 91: 3C–31S
  • Cerutti P. A. Prooxidant states and tumor promotion. Science 1985; 227: 375
  • Staal F. J. T., Roederer M., Herzenberg L. A., Herzenberg L. A. Intracellular thiols regulate activation of nuclear factor B and transcription of human immunodeficiency virus. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 9943
  • Schreck R., Rieber P., Baeurle P. A. Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-B transcription factor and HIV-1. EMBO J. 1991; 10: 2247
  • Trush M., Kensler T. W. An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radic. Biol. Med. 1991; 10: 201
  • Halliwell B., Gutteridge J. M. C. Role of free radicals and catalytic metal ions in human disease. An overview. Methods Enzymol. 1990; 186: 1
  • Plummer J. L., Smith B. R., Sies H. Y., Bend J. R. Chemical depletion of glutathione in vivo. Methods in Enzymology, W. B. Jakoby. Academic Press, New York 1981; Vol. 77: 50
  • Bannai S. Induction of cystine and glutamate transport activity in human fibroblasts by diethyl maleate and other electrophilic agents. J. Biol. Chem. 1984; 259: 2435
  • Powis G. Metabolism and reactions of quinoid anticancer agents. Pharmacol. Ther. 1987; 35: 57
  • Benson A. M., Hunkeler M. J., Talalay P. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc. Natl. Acad. Sci. U.S.A. 1980; 77: 5216
  • Chesis P. L., Levin D. E., Smith M. T., Ernster L., Ames B. N. Mutagenicity of quinones: pathways of metabolic activation and detoxification. Proc. Natl. Acad. Sci. U.S.A. 1984; 81: 1696
  • Lind C., Hochstein P., Ernster L. DT-Diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation. Arch. Biochem. Biophys. 1982; 216: 178
  • Goldstein B. D., Rozen M. G., Quintavalla J. C., Amoruso M. A. Decrease in mouse lung and liver glutathione peroxidase activity and potentiation of the lethal effects of ozone and paraquat by the superoxide dismutase inhibitor diethyldiothiocarbamate. Biochem. Pharmacol. 1979; 28: 27
  • Solanki V., Rana R., Slaga T. Diminution of mouse epidermal superoxide dismutase and catalase activities by tumor promoters. Carcinogenesis 1982; 2: 1141
  • Packard B. S., Saxton M. J., Bissell M. J., Klein M. P. Plasma membrane reorganization induced by tumor promoters in an epithelial cell line. Proc. Natl. Acad. Sci. U.S.A. 1984; 81: 449
  • Forman H. J., Boveris A. Free Radicals in Biology, E. Pryor. Academic Press, New York 1982; 65
  • Li G. C. Induction of thermotolerance and enhanced heat shock protein synthesis in Chinese hamster fibroblasts by sodium arsenite and by ethanol. J. Cell Physiol 1983; 115: 116
  • Kim Y. J., Shuman J., Sette M., Przybyia A. Arsenate induces stress proteins in cultured rat myoblasts. J. Cell Biol 1983; 96: 393
  • Bertolero F., Pozzi G., Sabioni E., Saffiotti U. Cellular uptake and metabolic reduction of pentavalent to trivalent arsenic as determinants of cytotoxicity and morphological transformation. Carcinogenesis 1987; 8: 803
  • Nohl H., De Silva D., Summer K. H. 2,3,7,8 Tetrachlorodibenzo-p-dioxin induces oxygen activation associated with cell respiration. Free Radic. Biol. Med. 1989; 6: 369
  • Christman M. F., Morgan R. W., Jacobson F. S., Ames B. N. Positive control of a region for defense against oxidative stress and some heat-shock proteins in Salmonella typhymurium. Cell 1985; 41: 753
  • Stortz G., Tartaglia L. A., Ames B. N. Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. Science 1990; 248: 189
  • Devary Y., Gottlieb R. A., Smeal T., Karin M. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase. Cell 1992; 71: 1081
  • Leonard Liang H. C, Shertzer H. G., Nebert D. W. “Oxidative Stress” response in liver of an untreated new born mouse having a 1,2-centimorgan deletion on chromosome 7. Biochem. Biophys. Res. Comm. 1992; 182: 1160
  • Eriksson L. C., Andersson G. N. Membrane biochemistry and chemical hepatocarcinogenesis. CRC Crit. Revs. Biochem. Mol. Biol. 1992; 27: 1
  • Farber E. Pre-cancerous steps in carcinogenesis. Their physiological adaptive nature. Biochem. Biophys. Acta 1984; 738: 171
  • Eriksson L. C., Blanck A., Bock K. W., Mannervik B. Metabolism of xenobiotics in hepatocyte nodules. Toxicol. Pathol. 1987; 15: 27
  • Fairchild C. R., Ivy S. P., Rushmore T., Lee G., Koo P., Goldsmith M. E., Meyers C. E., Farber E., Cowan K. H. Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc. Natl. Acad. Sci. U.S.A. 1987; 84: 7701
  • Thergeirsson S. S., Huber B. E., Sorell S., Fojo A., Pastan I., Gottesman M. M. Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. Science 1987; 236: 1120
  • Pickett C. B., Williams J. B., Lu A. Y. H., Cameron R. G. Regulation of glutathione transferase and DT-diaphorase mRNAs in persistent hepatocyte nodules during chemical hepatocarcinogenesis. Proc. Natl Acad. Sci. U.S.A. 1984; 81: 5091
  • Cowan K. H., Batist G., Tulpule A., Sinka B. K., Myers C. E. Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats. Proc. Natl. Acad. Sci. U.S.A. 1986; 83: 9328
  • Black S. M., Beggs J. D., Hayes J. D., Bartoszek A., Muramatsu M., Sakai M., Wolf R. Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil. Biochem. J. 1990; 268: 309
  • Manoharan T. H., Puchalski R. B., Burgess J. A., Pickett C. B., Fahl W. E. Promoter-glutathione S-transferase Ya cDNA hybrid genes. Expression and conferred resistance to an alkylating molecule in mammalian cells. J. Biol. Chem. 1987; 262: 3739
  • Fairchild C. R., Moscow J. A., O'Brien E. E., Cowan K. H. Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase. Mol. Pharmacol 1990; 37: 801
  • Leyland Jones B. R., Townsend A. J., Tu C. P., Cowan K. H., Goldsmith M. E. Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human α class glutathione S-transferase gene. Cancer Res. 1991; 51: 587

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