Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and Differentiation

References

• Bagchi S., Weinmann R., Raychaudhuri P. The retinoblastoma protein copurifies with E2F-1, an E1A-regulated inhibitor of the transcription factor E2F. Cell 1991; 65: 1063
   PubMed Web of Science ®Google Scholar
• Bates S., Bonetta L., MacAllan D., Parry D., Holder A., Dickson C., Peters G. CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin Dl. Oncogene 1994; 9: 71
   PubMed Web of Science ®Google Scholar
• Beijersbergen R. L., Carlée L., Kerk-Hoven R. M., Bernards R. Regulation of the retinoblastoma protein-related pi 07 by Gl cyclin complexes. Genes Dev. 1995; 9: 1340
   PubMedGoogle Scholar
• Beijersbergen R. L., Kerkhoven R. M., Zhu L., Carlée L., Voorhoeve P. M., Bernards R. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with pi07 in vivo. Genes Dev. 1994; 8: 2680
   PubMed Web of Science ®Google Scholar
• Bernards R., Schackleford G. M., Gerber M. R. H., Friend S. H., Schartl M., Bogenmann E., Rapaport J. M., McGee T., Dryja T. P., Weinberg R. A. Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein. Proc. Natl. Acad. Sci. U.S.A. 1989; 86: 6474
   PubMed Web of Science ®Google Scholar
• Bishop M. Molecular themes in onco-genesis. Cell 1991; 64: 235
   PubMed Web of Science ®Google Scholar
• Blake M. C., Azizkhan J. C. Transcription factor E2F is required for efficient expression of the hamster dihydro-folate reductase gene in vitro and in vivo. Mol. Cell. Biol 1989; 9: 4994
   PubMed Web of Science ®Google Scholar
• Bremner R., Cohen B. L., Sopta M., Hamel P. A., Ingles C. J., Gallie B. L., Phillips R. A. Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol. Cell. Biol. 1995; 15: 3256
   PubMedGoogle Scholar
• Buchkovich K., Duffy L. A., Harlow E. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 1989; 58: 1097
   PubMed Web of Science ®Google Scholar
• Buck V., Allen E. K., Sørensen T., Bybee A., Hijmans E. M., Voorhoeve P. M., Bernards R., La Thangue N. B. Molecular and functional characterization of E2F-5, a new member of the E2F family. Oncogene 1995; 11: 31
   PubMedGoogle Scholar
• Cao L., Faha B., Dembski M., Tsai L. H., Harlow E., Dyson N. Independent binding of the retinoblastoma protein and pi07 to the transcription factor E2F. Nature 1992; 355: 176
   PubMedGoogle Scholar
• Chang M. W., Barr E., Seltzer J., Jiang Y.-Q., Nabel G. J., Nabel E., Parmacek M. S., Leiden J. M. Cytostatic gene therapy for vascular prolif-erative disorders with a constitutively active form of the retinoblastoma gene product. Science 1995; 267: 518
   PubMed Web of Science ®Google Scholar
• Chen P. L., Scully P., Shew J. Y., Wang J. Y., Lee W. H. Phosphory-lation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 1989; 58: 1193
   PubMed Web of Science ®Google Scholar
• Chittenden T., Livingston D. M., DeCaprio J. A. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol. Cell. Biol. 1993; 13: 3975
   PubMedGoogle Scholar
• Claudio P. P., Howard C. M., Baldi A., De Luca A., Fu Y., Conorelli G., Sun Y., Colburn N., Calabretta B., Giordano A. p 130/pRb2 has growth-suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and pi07. Cancer Res. 1994; 54: 5556
   PubMed Web of Science ®Google Scholar
• Cobrinik D., Whyte P., Peeper D. S., Jacks T., Weinberg R. A. Cell cycle-specific association of E2F with the pi30 ElA-binding protein. Genes Dev. 1993; 7: 2392
   PubMed Web of Science ®Google Scholar
• Corbeil H. B., Whyte P., Branton P. E. Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. Oncogene 1995; 11: 909
   PubMedGoogle Scholar
• Cross H. E., Hansen R. C., Morrow G. D., Davis J. R. Retinoblastoma in a patient with a 13qXp translocation. Am. J. Ophthalmol 1977; 84: 548
   PubMedGoogle Scholar
• Dalton S. Cell cycle regulation of the human cdc2 gene. EMBO J. 1992; 11: 1797
   PubMed Web of Science ®Google Scholar
• DeCaprio J. A., Ludlow J. W., Figge J., Shew J. Y., Huang C. M., Lee W. H., Marsilio E., Paucha E., Livingston D. M. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 1988; 54: 275
   PubMed Web of Science ®Google Scholar
• DeCaprio J. A., Ludlow J. W., Lynch D., Furukawa Y., Griffin J., Piwnica W. H., Huang C. M., Livingston D. M. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 1989; 58: 1085
   PubMed Web of Science ®Google Scholar
• DeGregori J., Kowalik T., Nevins J. R. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis and Gl/S regulatory genes. Mol. Cell. BioL 1995; 15: 4215
   PubMed Web of Science ®Google Scholar
• Dowdy S. F., Hinds P. W., Louie K., Reed S. I., Arnold A., Weinberg R. A. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 1993; 73: 499
   PubMed Web of Science ®Google Scholar
• Dulic V., Lees E., Reed S.L. Association of human cyclin E with a periodic Gl-S phase protein kinase. Science 1958; 257: 1992
   Google Scholar
• Duronio R. J., O'Farrell P. H., Xie J.-E., Brook A., Dyson N. The transcription factor E2F is required for S phase duringDrosophilaembryogenesis. Genes Dev. 1995; 9: 1445
   PubMed Web of Science ®Google Scholar
• Dynlacht B. D., Brook A., Dembski M., Yenush L., Dyson N. DNA-binding and trans-activation properties ofDrosophilaE2F and DP proteins. Proc. Natl. Acad. Sci. U.S.A. 1994; 91: 6359
   PubMedGoogle Scholar
• Dynlacht B. D., Flores O., Lees J. A., Harlow E. Differential regulation of E2F frans-activation by cyclin/cdk2 complexes. Genes Dev. 1994; 8: 1772
   PubMed Web of Science ®Google Scholar
• Dyson N., Howley P. M., Miinger K., Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989; 242: 934
   Google Scholar
• Endo T., Goto S. Retinoblastoma gene product Rb accumulates during myo-genic differentiation and is deinduced by the expression of SV40 large T antigen. J. Biochem. (Tokyo) 1992; 112: 427
   PubMedGoogle Scholar
• Evans T., Rosenthal E. T., Youngblom J., Distel D., Hunt T. Cyclin: a protein specified by maternal mRNA in sea urchin eggs is destroyed at each cleavage division. Cell 1983; 33: 389
   PubMed Web of Science ®Google Scholar
• Ewen M. E., Faha B., Harlow E., Livingston D. M. Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science 1992; 255: 85
   PubMed Web of Science ®Google Scholar
• Ewen M. E., Sluss H. K., Sherr C. J., Matsushime H., Kato J., Livingston D. M. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 1993; 73: 487
   PubMed Web of Science ®Google Scholar
• Ewen M. E., Xing Y. G., Lawrence J. B., Livingston D. M. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 1991; 66: 1155
   PubMed Web of Science ®Google Scholar
• Faha B., Ewen M. E., Tsai L.-H., Livingston D. M., Harlow E. Interaction between human cyclin A and ad-enovirus El A-associated p1 07 protein. Sci-ence 1992; 255: 87
   PubMed Web of Science ®Google Scholar
• Figge J., Webster T., Smith T. F., Paucha E. Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A and myc oncogenes. J. Virol 1988; 62: 1814
   PubMedGoogle Scholar
• Flemington E. K., Speck S. H., Kaelin W. G., Jr. E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. U.S.A. 1993; 90: 6914
   PubMed Web of Science ®Google Scholar
• Francke U. Retinoblastoma and chromosome 13. Cytogenet. Cell. Genet. 1976; 16: 131
   PubMedGoogle Scholar
• Francke U., Kung F. Sporadic bilateral retinoblastoma and 13q-chromo-somal deletion. Med. Pediatr. Oncol. 1976; 2: 379
   PubMedGoogle Scholar
• Friend S. H., Bernards R., Rogelj S., Weinberg R. A., Rapaport J. M., Albert D. M., Dryja T. P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986; 323: 643
   PubMed Web of Science ®Google Scholar
• Gallie B. L. Retinoblastoma, molecular genetics. Encyclop. Hum. Biol 1991; 6: 633
   Google Scholar
• Gallie B. L., Dunn J. M., Chan H. S., Hamel P. A., Phillips R. A. The genetics of retinoblastoma. Relevance to the patient. Pediatr. Clin. North Am. 1991; 38: 299
   PubMed Web of Science ®Google Scholar
• Gardner H. A., Gallie B. L., Knight L. A., Phillips R. A. Multiple karyo-typic changes in retinoblastoma tumor cells: presence of normal chromosome 13 in most tumors. J. Cancer Genet. Cytogenet 1982; 6: 201
   PubMed Web of Science ®Google Scholar
• Gill R. M., Kiess M., Hamel P. A. Full-length pRB decreases the affinity of E2F complexes for DNA. J. Biol. Chem. (submitted) 1995
   Google Scholar
• Ginsberg D., Vairo G., Chittenden T., Xiao Z.-X., Xu G., Wydner K. L., DeCaprio J. A., Lawrence J. B., Livingston D. M. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994; 8: 2665
   PubMed Web of Science ®Google Scholar
• Girard F., Strausfeld U., Fernandez A., Lamb N. J. C. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 1991; 67: 1169
   PubMed Web of Science ®Google Scholar
• Girling R., Bandara L. R., Ormondroyd E., Lam E. W.-F., Kotecha S., Mohun T., La Thangue N. B. Molecular characterization ofXenopus laevisDP proteins. Mol. Biol. Cell 1994; 5: 1081
   PubMedGoogle Scholar
• Girling R., Partridge J. F., Bandara L. R., Burden N., Totty N. F., Hsuan J. J., La Thangue N. B. A new component of the transcription factor DRTF1/E2F. Nature 1993; 362: 83
   PubMed Web of Science ®Google Scholar
• Grabowski E. F., Abramson D. H. Intraocular and extraocular retinoblastoma. Hematol. Oncol. Clin. North Am. 1987; 1: 721
   PubMedGoogle Scholar
• Hadwiger J. A., Wittenberg C, Richardson H. E., de Barros Lopes M., Reed S. L. A family of cyclin ho-mologs that control the Gl phase in yeast. Proc. Natl. Acad. Sci. U.S.A. 1989; 86: 6255
   PubMedGoogle Scholar
• Hamel P. A., Gill M., Phillips R. A., Gallie B. L. Regions controlling hyper-phosphorylation and conformation of the retinoblastoma gene product are independent of domains required for tran-scriptional repression. Oncogene 1992; 7: 693
   PubMedGoogle Scholar
• Hamel P. A., Gill R. M., Phillips R. A., Gallie B. L. Transcriptional repression of the E2-containing promoters EIIaE,c-mycandRBIby the product of theRBIgene. Mol. Cell. Biol. 1992; 12: 3431
   PubMed Web of Science ®Google Scholar
• Hamel P. A., Phillips R. A., Muncaster M., Gallie B. L. Speculations on the roles ofRBIin tissue-specific differentiation, tumor initiation and tumor progression. FASEB J. 1993; 7: 846
   PubMed Web of Science ®Google Scholar
• Hanna Z., Jankowski M., Tremblay P., Jiang X., Milatovitch A., Francke U., Jolicoeur P. Thevin-1 gene, identified by provirus insertional muta-genesis, is the cyclin D2. Oncogene 1993; 8: 1661
   PubMed Web of Science ®Google Scholar
• Hannon G. J., Demetrick D., Beach D. Isolation of the Rb-related p 130 through its interaction with cdk2 and cyclins. Genes Dev. 1993; 7: 2378
   PubMed Web of Science ®Google Scholar
• Hansen M. F., Cavenee W. K. Retinoblastoma and the progression of tumor genetics. Trends Genet. 1988; 4: 125
   PubMedGoogle Scholar
• Harlow E. Retinoblastoma. For our eyes only. Nature 1992; 359: 270
   PubMed Web of Science ®Google Scholar
• Harlow E., Whyte P., Franza B. R., Schley C. Association of Adenovi-rus early-region 1A proteins with cellular polypeptides. Mol. Cell. Biol. 1986; 6: 1579
   PubMed Web of Science ®Google Scholar
• Hartwell L. H., Weinert T. A. Checkpoints: Controls that ensure order of cell cycle events. Science 1989; 246: 639
   Google Scholar
• Hatakeyama M., Brill J. A., Fink G. R., Weinberg R. A. Collaboration of Gl cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev. 1994; 8: 1759
   PubMed Web of Science ®Google Scholar
• Helin K., Harlow E., Fattaey A. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 1993; 13: 6501
   PubMed Web of Science ®Google Scholar
• Helin K., Lees J. A., Vidal M., Dyson N., Harlow E., Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 1992; 70: 337
   PubMed Web of Science ®Google Scholar
• Helin K., Wu C, Fattaey A. R., Lees J. A., Dynlacht B. D., Ngwu C., Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative frans-activation. Genes Dev. 1993; 7: 1850
   PubMed Web of Science ®Google Scholar
• Hiebert S. W., Blake M., Azizkhan J., Nevins J. R. Role of E2F transcription factor in ElA-mediated trans activation of cellular genes. J. Virol 1991; 65: 3547
   PubMedGoogle Scholar
• Hiebert S. W., Chellappan S. P., Horowitz J. M., Nevins J. R. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev 1992; 6: 111
   Google Scholar
• Hijmans E. M., Voorhoeve P. M., Beijersbergen R. L., Van't Veer L. J., Bernards R. E2F-5, a new E2F family member that interacts with pi30 in vivo. Mol. Cell Biol. 1995; 15: 3082
   PubMedGoogle Scholar
• Hinds P. W., Mittnacht S., Dulic V., Arnold A., Reed S. I., Weinberg R. A. Regulation of retinoblastoma functions by ectopic expression of human cyclins. Cell 1992; 70: 993
   PubMed Web of Science ®Google Scholar
• Hu Q. J., Dyson N., Harlow E. The regions of the retinoblastoma protein needed for binding to adeno virus El A or SV40 large T antigen are common sites for mutations. EMBO J. 1990; 9: 1147
   PubMed Web of Science ®Google Scholar
• Huang H. J., Yee J. K., Shew J. Y., Chen P. L., Bookstein R., Friedmann T., Lee E. Y., Lee W. H. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 1988; 242: 1563
   PubMed Web of Science ®Google Scholar
• Hunter T. Oncogenes and the cell cycle. Curr. Opin. Genet. Dev. 1993; 3: 1
   Google Scholar
• Hunter T., Pines J. Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell 1994; 4: 573
   Google Scholar
• Ivey-Hoyle M., Conroy R., Huber H., Goodhart P. J., Oliff A., Heim-Brook D. C. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell Biol. 1993; 13: 7802
   PubMed Web of Science ®Google Scholar
• Jacks T., Fazeli A., Schmitt E. M., Bronson R. T., Goodell M. A., Weinberg R. A. Effects of an Rb mutation in the mouse. Nature 1992; 359: 295
   PubMed Web of Science ®Google Scholar
• Johnson D. G., Schwarz J. K., Cress W. D., Nevins J. R. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 1993; 365: 349
   PubMed Web of Science ®Google Scholar
• Kaelin W. G., Jr, Ewen M. E., Livingston D. M. Definition of the minimal simian virus 40 large T antigen- and adenovirus ElA-binding domain in the retinoblastoma gene product. Mol. Cell. Biol. 1990; 10: 3761
   PubMed Web of Science ®Google Scholar
• Kaelin W. G., Jr, Krek W., Sellers W. R., DeCaprio J. A., Ajchenbaum R., Fuchs C. S., Chittenden T., Li Y., Farnham P. J., Blanar M. A., Livingston D. M., Flemington E. K. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 1992; 70: 351
   PubMed Web of Science ®Google Scholar
• Karlseder J., Rotheneder H., Wintersberger E. Interaction of Spl with the growth- and cell cycle-regulated transcription factor E2F. Mol. Cell. Biol. 1996; 16: 1659
   PubMed Web of Science ®Google Scholar
• Kato J., Matsushime EL, Hiebert S. W., Ewen M. E., Sherr C. J. Direct binding of cyclin D to the retinoblastoma gene product (pRB) and pRB phosphory-lation by the cyclin D-dependent kinase CDK4. Genes Dev. 1993; 7: 331
   PubMed Web of Science ®Google Scholar
• Kiess M., Gill R. M., Hamel P. A. Expression and activity of the retinoblastoma protein (pRB)-family proteins, pi07 and pi30, during L6myoblast differentiation. Cell Growth Differ. 1995; 6: 1287
   PubMedGoogle Scholar
• Kipreos E. T., Wang J. Y. Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA. Science 1992; 256: 382
   PubMed Web of Science ®Google Scholar
• Kitagawa M., Higashi H., Suzuki-Takahashi I., Segawa K., Hanks S. K., Taya Y., Nishimura S., Okuyama A. Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene 1995; 10: 229
   PubMed Web of Science ®Google Scholar
• Knoblich J. A., Sauer K., Jones L., Richardson H., Saint R., Lehner C. F. Cyclin E controls S phase progression and its down-regulation duringDroso-philaembryogenesis is required for the arrest of cell proliferation. Cell 1994; 77: 107
   PubMed Web of Science ®Google Scholar
• Knudson A. G. J. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. U.S.A. 1971; 68: 820
   PubMed Web of Science ®Google Scholar
• Knudson A. G. J., Hethcote H. W., Brown B. W. Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc. Natl. Acad. Sci. U.S.A. 1975; 72: 5116
   PubMed Web of Science ®Google Scholar
• Knudson A. G. J., Meadows A. T., Nichols W. W., Hill R. Chromosomal deletion and retinoblastoma. N. Engl. J. Med. 1976; 295: 1120
   PubMed Web of Science ®Google Scholar
• Koff A., Cross F., Fisher A., Schumacher J., LeGuellec K., Phillippe M., Roberts J. Human cyclin E: a new cyclin that interacts with two members of theCDC2gene family. Cell 1991; 66: 1217
   PubMed Web of Science ®Google Scholar
• Koff A., Giordano A., Desai D., Yamashita K., Harper J. W., Elledge S., Nishimoto T., Morgan D. O., Franza B. R., Roberts J. M. Formation and activation of a cyclin E-cdk2 complex during the Gl phase of the human cell cycle. Science 1992; 257: 1689
   PubMed Web of Science ®Google Scholar
• Kovesdi I., Reichel R., Nevins J. R. Identification of a cellular transcription factor involved in El A trans-activation. Cell 1986; 45: 219
   PubMed Web of Science ®Google Scholar
• Krek W., Ewen M. E., Shirodkar S., Arany Z., Kaelin W. G., Jr, Livingston D. M. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-depen-dent protein kinase. Cell 1994; 78: 161
   PubMed Web of Science ®Google Scholar
• Krek W., Gangfeng X., Livingston D. M. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 1995; 83: 1149
   PubMed Web of Science ®Google Scholar
• Laskey R. A., Fairman M. P., Blow J. J. S phase of the cell cycle. Science 1989; 246: 609
   PubMed Web of Science ®Google Scholar
• Lee E. Y., Huang S., Shew J. Y., Donoso L. A., Lee W. H. Diverse mutations lead to inactivation of the retinoblastomagene. Prog. Clin. Biol. Res. 1991; 362: 221
   Google Scholar
• Lee E. Y.H.P., Chang C. Y., Hu N., Wang Y. C. J., Lai C. C., Herrup K., Lee W. H., Bradley A. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 1992; 359: 288
   PubMed Web of Science ®Google Scholar
• Lee W. H., Shew J. Y., Hong F. D., Sery T. W., Donoso L. A., Young L. J., Bookstein R., Lee E. Y. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 1987; 329: 642
   PubMed Web of Science ®Google Scholar
• Lees E., Faha B., Dulic V., Reed S. I., Harlow E. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 1992; 6: 1874
   PubMed Web of Science ®Google Scholar
• Lees E. M., Harlow E. Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase. Mol Cell. Biol. 1993; 13: 1194
   PubMed Web of Science ®Google Scholar
• Lees J. A., Buchkovich K. J., Marshak D. R., Anderson C. W., Harlow E. The retinoblastoma protein is phosphory-lated on multiple sites by human cdc2. EMBO J. 1991; 10: 4279
   PubMed Web of Science ®Google Scholar
• Lees J. A., Saito M., Vidal M., Valentine M., Look T., Harlow E., Dyson N., Helin K. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol 1993; 13: 7813
   PubMed Web of Science ®Google Scholar
• Lew D. J., Dulic V., Reed S. I. Isolation of three novel human cyclins by rescue of Gl cyclin (Cln) function in yeast. Cell 1991; 66: 1197
   PubMed Web of Science ®Google Scholar
• Lewin B. Driving the cell cycle: M phase kinase, its partners, and substrates. Cell 1990; 61: 743
   PubMed Web of Science ®Google Scholar
• Li Y., Graham C, Lacy S., Duncan A. M. V., Whyte P. The adenovirus Ela-associated 130-kDaprotein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev. 1993; 7: 2366
   PubMed Web of Science ®Google Scholar
• Lillie J. W., Green M., Green M. R. An adenovirus Ela protein region required for transformation and transcriptional repression. Cell 1986; 46: 1043
   PubMed Web of Science ®Google Scholar
• Lillie J. W., Loewenstein P. M., Green M. R. Functional domains of adenovirus type 5 El A proteins. Cell 1987; 50: 1091
   PubMedGoogle Scholar
• Lin B. T., Gruenwald S., Morla A. O., Lee W. H., Wang J. Y. Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J. 1991; 10: 857
   PubMed Web of Science ®Google Scholar
• Lin S.-Y., Black A. R., Kostic D., Pajovic S., Hoover C. N., Azizkhan J. C. Cell cycle-regulated association of E2F1 and Spl is related to their functional interaction. Mol Cell Biol. 1996; 16: 1668
   PubMed Web of Science ®Google Scholar
• Loeken M. R., Brady J. The adenovirus EIIA enhancer. Biol. Chem. 1989; 264: 6572
   Google Scholar
• Logan T. J., Evans D. L., Mercer W. E., Bjornsti M. A., Hall D. J. Expression of a deletion mutant of the E2F1 transcription factor in fibroblasts lengthens S phase and increases sensitivity to S phase-specific toxins. Cancer Res. 1995; 55: 2883
   PubMedGoogle Scholar
• Ludlow J. W., DeCaprio J. A., Huang C. M., Lee W.-H., Paucha E., Livingston D. M. SV40 large T antigen binds preferentially to an underphos-phorylated member of the retinoblastoma susceptibility gene product family. Cell 1989; 56: 57
   PubMed Web of Science ®Google Scholar
• Ludlow J. W., Shon J., Pipas J. M., Livingston D. M., DeCaprio J. A. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 1990; 60: 387
   PubMed Web of Science ®Google Scholar
• Matsushime H., Ewen M. E., Strom D. K., Kato J. Y., Hanks S. K., Roussel M. F., Sherr C. J. Identification and properties of an atypical catalytic sub-unit (p34PSK-J3/cdk4) for mammalian D type Gl cyclins. Cell 1992; 71: 323
   PubMed Web of Science ®Google Scholar
• Matsushime H., Roussel M. F., Ashmun R. A., Sherr C. J. Colony-stimulating factor 1 regulates novel cyclins during the Gl phase of the cell cycle. Cell 1991; 65: 701
   PubMed Web of Science ®Google Scholar
• Mayol X., Garriga J., Grafia X. Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130. Oncogene 1995; 11: 801
   PubMed Web of Science ®Google Scholar
• Mayol X., Gratia X., Baldi A., Sang N., Hu Q., Giordano A. Cloning of a new member of the retinoblastoma gene family (pRB2) that binds to the Ela transforming domain. Oncogene 1993; 8: 2561
   PubMed Web of Science ®Google Scholar
• McCormick F., Clark R., Harlow E., Tjian R. SV40 T antigen binds specifically to a 53 K protein. in vitro, Nature 1981; 292: 63
   PubMed Web of Science ®Google Scholar
• McIntosh J. R., Koonce M. P. Mitosis. Science 1989; 246: 622
   PubMedGoogle Scholar
• Means A. L., Slansky J. E., McMahon S. L., Knuth M. W., Farnham P. J. The HIP1 binding site is required for growth regulation of the dihydrofolate re-ductase gene promoter. Mol. Cell. Biol. 1992; 12: 1054
   PubMedGoogle Scholar
• Meyerson M., Harlow E. Identification of Gl kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol. 1994; 14: 2077
   PubMed Web of Science ®Google Scholar
• Mihara K., Cao X. R., Yen A., Chandler S., Driscoll B., Murphree A. L., Tang A., Fung Y. K. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 1989; 246: 1300
   PubMed Web of Science ®Google Scholar
• Mittnacht S., Lees J. A., Desai D., Harlow E., Morgan D. O., Wein-Berg R. A. Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J. 1994; 13: 118
   PubMed Web of Science ®Google Scholar
• Moberg K., Starz M. A., Lees J. A. E2F-4 switches from pi30 to pi07 and pRB in response to cell cycle entry. Mol. Cell. Biol 1996; 16: 1436
   PubMed Web of Science ®Google Scholar
• Moberg K. H., Logan T.T.D. J.J. Three distinct elements within the murine c-myc promoter are required for transcription. Oncogene 1992; 7: 411
   PubMedGoogle Scholar
• Moran E. A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products. Nature 1988; 334: 168
   PubMed Web of Science ®Google Scholar
• Moran E. DNA tumor virus transforming proteins and the cell cycle. Curr. Opin. Genet. Dev. 1993; 3: 63
   PubMed Web of Science ®Google Scholar
• Moreno S., Nurse P. Substrates for p34cbc2: in vivo veritas. Cell 1990; 61: 549
   PubMed Web of Science ®Google Scholar
• Motokura T., Bloom T., Kim H. G., Jiippner H., Ruderman J. V., Kronen-Berg H. M., Arnold A. A novel cyclin encolded by abell-linked candidate oncogene. Nature 1991; 350: 512
   PubMed Web of Science ®Google Scholar
• Motokura T., Keyomarsi K., Kronen-Berg H. M., Arnold A. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRADl/cyclin Dl proto-oncogene. J. Biol. Chem. 1992; 267: 20412
   PubMed Web of Science ®Google Scholar
• Mudryj M., Devoto S. H., Hiebert S. W., Hunter T., Pines J., Nevins J. R. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 1991; 65: 1243
   PubMed Web of Science ®Google Scholar
• Mudryj M., Hiebert S. W., Nevins J. R. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 1990; 9: 2179
   PubMedGoogle Scholar
• Muncaster M., Cohen B., Phillips R. A., Gallie B. L. Failure of RBI to reverse the malignant phenotype of human tumors cell lines. Cancer Res. 1992; 52: 654
   PubMedGoogle Scholar
• Miinger K., Werness B. A., Dyson N., Phelps W. C., Harlow E., Howley P. M. Complex formation of human pap-illomavirus E7 proteins with the retino-blastoma tumor suppressor gene product. EMBO J. 1989; 8: 4099
   PubMedGoogle Scholar
• Munger K., Yee C. L., Phelps W. C., Pietenpol J. A., Moses H. L., Howley P. M. Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillo-mavirus types are determined by amino-terminal sequences. J. Virol. 1991; 65: 3943
   PubMed Web of Science ®Google Scholar
• Murray A. W., Kirschner M. W. Dominos and clocks: the union of two views of the cell cycle. Science 1989; 246: 614
   PubMed Web of Science ®Google Scholar
• Neuman E., Flemington E. K., Sellers W. R., Kaelin W. G. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 1994; 14: 6607
   PubMed Web of Science ®Google Scholar
• Nurse P. Universal control mechanism regulating onset of M-phase. Nature 1990; 344: 503
   PubMed Web of Science ®Google Scholar
• O'Farrell P. H., Edgar B. A., Lakich D., Lehner C. F. Directing cell division during development. Science 1989; 246: 635
   PubMed Web of Science ®Google Scholar
• Ohtsubo M., Theodoras A. M., Schumacher J., Roberts J. M., Pagano M. Human cyclin E, a nuclear protein essential for the Gl-to-S phase transition. Mol. Cell Biol. 1995; 15: 2612
   PubMed Web of Science ®Google Scholar
• Pagano M., Peppercock R., Verde C, Ansorge W., Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO J. 1992; 11: 961
   PubMed Web of Science ®Google Scholar
• Pearson B. E., Nasheuer H. P., Wang T. S. F. Human DNA polymerase a gene, sequences controlling expression in cycling and serum-stimulated cells. Mol. Cell. Biol. 1991; 11: 2081
   PubMedGoogle Scholar
• Phelps W.C., Yee C. L., Munger K., Howley P. M. The human papillo-mavirus type 16 E7 gene encodes trans-activation and transformation functions similar to those of adenovirus El A. Cell 1988; 53: 539
   PubMed Web of Science ®Google Scholar
• Phillips R. A., Gill R. M., Zacksenhaus E., Bremner R., Jiang Z., Sopta M., Gallie B. L., Hamel P. A. Why don't germline mutations inRBIpredispose to leukemia. Curr. Top. Microbiol. Immunol. 1992; 182: 485
   PubMedGoogle Scholar
• Pines J., Hunter T. p34cdc2. the S and M Kinase. The New Biologist. 1990; 2: 389
   PubMedGoogle Scholar
• Qin X., Livingston D. M., Kaelin W. G., Adams P. D. Deregulated expression of E2F-1 in low serum leads to S-phase entry and p53-dependent apopto-sis. The Cell Cycle 1994; 106
   Google Scholar
• Rabbitts P. H., Watson J. V., Lamond A., Forster A., Stinson M. A., Evan G., Atherton E., Sheppard R., Rabbitts T. H. Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle. EMBO J. 1985; 4: 2009
   PubMed Web of Science ®Google Scholar
• Reed S. I. The role of the p34 kinases in the Gl to S-phase transition. Ann. Rev. Cell Biol. 1992; 8: 529
   PubMedGoogle Scholar
• Resnitzky D., Hengst L., Reed S. I. Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in Gl by p27KiP1. Mol. Cell. Biol. 1995; 15: 4347
   PubMedGoogle Scholar
• Resnitzky D., Reed S. Different roles for cyclins D1 and E in regulation of the Gl-to-S transition. Mol Cell. Biol. 1995; 15: 3463
   PubMed Web of Science ®Google Scholar
• Sardet C, Vidal M., Cobrinik D., Geng Y., Onufryk C, Chen A., Weinberg R. A. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. U.S.A. 1995; 92: 2403
   PubMedGoogle Scholar
• Schneider J. W., Gu W., Zhu L, Mahdavi V., Nadal-Ginard B. Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science 1994; 264: 1467
   PubMed Web of Science ®Google Scholar
• Schwarz J. K., Devoto S. H., Smith E. J., Chellappan S. P., Jakoi L., Nevins J. R. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBOJ. 1993; 12: 1013
   PubMed Web of Science ®Google Scholar
• Shan B., Durfee T., Lee W.-H. Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis. Proc. Natl. Acad. Sci. U.S.A. 1996; 93: 679
   PubMed Web of Science ®Google Scholar
• Shan B., Lee W.-H. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 1994; 14: 8166
   PubMedGoogle Scholar
• Shan B., Zhu X., Chen P. L., Durfee T., Yang Y., Sharp D., Lee W. H. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 1992; 12: 5620
   PubMed Web of Science ®Google Scholar
• Shao Z., Ruppert S., Robbins P. D. The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250. Proc. Natl. Acad. Sci. U.S.A. 1995; 92: 3115
   PubMed Web of Science ®Google Scholar
• Sherr C. J. Mammalian Gl cyclins. Cell 1993; 73: 1059
   PubMed Web of Science ®Google Scholar
• Sherr C. J. Gl phase progression: cycling on cue. Cell 1994; 4: 551
   Google Scholar
• Sherr C. J., Roberts J. M. Inhibitors of mammalian Gl cyclin-dependent kinases. Genes Dev. 1995; 9: 1149
   PubMed Web of Science ®Google Scholar
• Shin E. K., Shin A., Paulding C, Schaffhausen B., Yee A. S. Multiple changes in E2F function and regulation occur upon muscle differentiation. Mol. Cell. Biol. 1995; 15: 2252
   PubMedGoogle Scholar
• Shirodkar S., Ewen M., DeCaprio J. A., Morgan J., Livingston D. M., Chittenden T. The transcripton factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 1992; 68: 157
   PubMed Web of Science ®Google Scholar
• Singh P., Wong S. H., Hong W. Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J. 1994; 13: 3329
   PubMed Web of Science ®Google Scholar
• Slack R. S., Hamel P. A., Bladon T. S., Gill R. M., McBurney M. Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells. Oncogene 1993; 8: 1585
   PubMedGoogle Scholar
• Slansky J. E., Li Y., Kaelin W. G., Farnham P. J. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 1993; 12: 5620
   Google Scholar
• Smith E. J., Nevins J. The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2. Mol. Cell. Biol. 1995; 15: 338
   PubMedGoogle Scholar
• Solomon M., Glotzer M., Lee T., PhiUippe M., Kirschner M. Cyclin activation of p34cdc2. Cell 1990; 63: 1013
   PubMed Web of Science ®Google Scholar
• Sparkes R. S., Murphree A. L., Lingua R. W., Sparkes M. C., Field L. L., Funderburk S. J., Benedict W. F. Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to Esterase D. Science 1983; 219: 971
   PubMed Web of Science ®Google Scholar
• Sparkes R. S., Sparkes M. C., Wilson M. G., Towner J. W., Benedict W., Murphree A. L., Yunis J. J. Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14. Science 1980; 208: 1042
   PubMed Web of Science ®Google Scholar
• Squire J., Phillips R. A., Boyce S., Godbout R., Rogers B., Gallie B. L. Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: verification by standard staining techniques, new densitometric methods, and somatic cell hybridization. Hum. Genet. 1984; 66: 46
   PubMedGoogle Scholar
• Standart N., Minshull J., Pines J., Hunt T. Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte. Dev. Biol. 1987; 124: 248
   PubMedGoogle Scholar
• Suzuki-Takahashi I., Kitagawa M., Saijo M., Higashi H., Ogino H., Matsumoto H., Taya Y., Nishimura S., Okuyama A. The interactions of E2F with pRB and with pi07 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase. Onco-gene 1995; 10: 1691
   Google Scholar
• Swenson K. I., Farrell K. M., Ruderman J. V. The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis inXenopusoocytes. Cell 1986; 47: 861
   PubMed Web of Science ®Google Scholar
• Thalmeier K., Synovzik H., Mertz R., Winnacker E. L., Lipp M. Nuclear factor E2F mediates basic transcription and trans-activation by E1 a of the human MYC promoter. Genes Dev. 1989; 3: 527
   PubMedGoogle Scholar
• Tsai L.-H., Harlow E., Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus El A-associated p33 kinase. Nature 1991; 353: 174
   PubMed Web of Science ®Google Scholar
• Tyers M., Tokiwa G., Nash R., Fitch I., Futcher B. Biochemical characterization of the Gl cyclins of 5.cerevisiae. The Cell Cycle. Abstracts of papers presented at the LVI Cold Spring Harbor Symposium on Quantitative Biology, May 29 to June 5, 1991, D. Beach, B. Stillman, J. D. Watson. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1991
   Google Scholar
• Vairo G., Livingston D. M., Ginsberg D. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev. 1995; 9: 869
   PubMed Web of Science ®Google Scholar
• Wade M., Blake M. C, Jambou R. C, Helin K., Harlow E., Azizkhan J. C. An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene. J. Biol. Chem. 1995; 270: 9783
   PubMedGoogle Scholar
• Wang C, Petryniak B., Thompson C. B., Kaelin W. G., Leiden J. M. Regulation of the Ets-related transcription factor Elf-1 by binding the retinoblastoma protein. Science 1993; 260: 1330
   PubMed Web of Science ®Google Scholar
• Weinberg R. A. The molecular basis of retinoblastomas. Ciba Found. Symp. 1989; 142: 99
   Google Scholar
• Weintraub S. J., Chow K. N. B., Luo R. X., Zhang S. H., He S., Dean D. C. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 1995; 375: 812
   PubMed Web of Science ®Google Scholar
• Weintraub S. J., Prater C. A., Dean D. C. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 1992; 358: 259
   PubMed Web of Science ®Google Scholar
• Welch P. J., Wang J. Y. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 1993; 75: 779
   PubMed Web of Science ®Google Scholar
• Whyte P., Buchkovich K. J., Horowitz J. M., Friend S. H., Raybuck M., Weinberg R. A., Harlow E. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 1988; 334: 124
   PubMed Web of Science ®Google Scholar
• Whyte P., Ruley H. E., Harlow E. Two regions of the adenovirus early region 1A proteins are required for transformation. J Virol. 1988; 62: 257
   PubMed Web of Science ®Google Scholar
• Williams B. O., Schmitt E. M., Remington L., Bronson R. T., Alvert D. M., Weinberg R. A., Jacks T. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBOJ. 1994; 13: 4251
   PubMed Web of Science ®Google Scholar
• Williams R. T., Carbonaro H. D. A., Hall F. L. Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein. Oncogene 1992; 1: 423
   Google Scholar
• Wittenberg C, Sugimoto K., Reed S. I. Gl -specific cyclins ofS. cerevisiae:cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell 1990; 62: 225
   PubMed Web of Science ®Google Scholar
• Wu C.-L., Zukerberg L. R., Ngwu C, Harlow E., Lees J. A. In vivo association of E2F and DP family proteins. Mol. Cell. Biol. 1995; 15: 2536
   PubMed Web of Science ®Google Scholar
• Xiong Y., Connolly T., Futcher B., Beach D. Human D-type cyclin. Cell 1991; 65: 691
   PubMed Web of Science ®Google Scholar
• Xu M., Sheppard K.-A., Peng C.-Y., Yee A. S., Piwnica-Worms H. Cyclin A/cdk2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. 1994; 14: 8420
   PubMed Web of Science ®Google Scholar
• Yande U. D. W., Campbell T. A., Dayton S. H., Petersen R., Walton D., Little J. B., Mc Conkie-Rosell A., Buckley E. G., Dryja T. P. Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. N. Engl. J. Med. 1989; 321: 1689
   Google Scholar
• Yee A. S., Reichel R., Kovesdi I., Nevins J. R. Promoter interaction of the ElA-inducible factor E2F and its potential role in the formation of a multi-component complex. EMBO J. 1987; 6: 2061
   PubMed Web of Science ®Google Scholar
• Yee S. P., Branton P. E. Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypep-tides. Virology 1985; 147: 142
   PubMed Web of Science ®Google Scholar
• Yunis J. J., Ramsay N. Retinoblastoma and subband deletion of chromosome 13. Am. J. Dis. Child. 1978; 132: 161
   PubMedGoogle Scholar
• Zamanian M., La Thangue N. B. Transcriptional repression by the Rb-re-lated protein p107. Mol. Cell. Biol. 1993; 4: 389
   Google Scholar
• Zamanian M., La T. N. B. Adenovirus Ela prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor. EMBO J. 1992; 11: 2603
   PubMedGoogle Scholar
• Zhang Y., Chellapan S. P. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene 1995; 10: 2085
   PubMed Web of Science ®Google Scholar
• Zhu L., Enders G., Lees J. A., Beijersbergen R. L., Bernards R., Harlow E. The pRB related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 1995; 14: 1904
   PubMed Web of Science ®Google Scholar
• Zhu L., Harlow E., Dynlacht D. p107 uses a p21ciplw-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 1995; 9: 1740
   PubMed Web of Science ®Google Scholar
• Zhu L., van den Heuvel S., Helin K., Fattaey A., Ewen M., Livingston D., Dyson N., Harlow E. Inhibition of cell proliferation by pi07, a relative of the retinoblastoma protein. Genes Dev. 1993; 7: 1111
   PubMed Web of Science ®Google Scholar
• Zhu L., Zhu L., Xie E., Chang L.-S. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol. Cell. Biol. 1995; 15: 3552
   PubMed Web of Science ®Google Scholar