Hyperleukocytic Leukemias and Leukostasis: A Review of Pathophysiology, Clinical Presentation and Management

References

• Estey H.E., Kantarjian H.M., Keating M.J. Therapy for acute myeloid leukemia. Hematology: Basic principles and Practice, 2nd ed, R. Hoffman, E.J. Benz, S.J. Shattil, B. Furie, H.J. Cohen, L.E. Silberstein. Churchill Livingstone, New York 1995; 1014–1028
   Google Scholar
• Cortes J.E., Kantarjian H.M. Acute lymphoblastic leukemia: a comprehensive review with emphasis on biology and therapy. Cancer 1995; 76: 2393–2405
   PubMed Web of Science ®Google Scholar
• Litchmann M.A., Heal J., Rowe J.M. Hyperleuko-cytic leukemia: rheological and clinical features and management. Baill. Clinical Hematol 1987; 1: 725–742
   PubMedGoogle Scholar
• Freireich E.J., Thomas L.B., Frei E., III, Fritz R.D., Forhman C.E. A distinctive type of intracerebral hemorrhage associated with blast crisis in patients with leukemia. Cancer 1960; 13: 146–150
   PubMed Web of Science ®Google Scholar
• Fritz R.D., Forkner C.E., Freireich E.J., Frei E., Thomas L.B. The association of fatal intracranial hemorrhage and blastic crisis in patients with acute leukemia. N. Engl. J. Med 1959; 261: 59–64
   PubMed Web of Science ®Google Scholar
• McCarthy L.J., Danielson C.F., Rothenberg S.S. Indications for emergency apheresis procedures. Crit. Rev. Clin. Lab. Sci 1997; 34: 573–610
   PubMed Web of Science ®Google Scholar
• Eisenstaedt R.S., Beckman E.M. Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. Transfusion 1978; 18: 113–115
   PubMed Web of Science ®Google Scholar
• Bloom R., Taviera DaSilva A.M., Bracey A. Reversible respiratory failure due to intravascular leukostasis in chronic myelogenous leukemia. Am. J. Med 1979; 67: 679–681
   PubMed Web of Science ®Google Scholar
• Karp D.D., Beck J.R., Cornell C.J. Chronic granulocytic leukemia with respiratory distress. Efficacy of emergency leukapheresis. Arch. Int. med 1981; 141: 1353–1355
   Web of Science ®Google Scholar
• Lane T.A. Continuous flow leukapheresis for rapid cytoreduction in leukemia. Transfusion 1980; 20: 455–457
   PubMed Web of Science ®Google Scholar
• Metha A.B., Goldman J.M., Kohner E. Hyperleukocytic retinopathy in chronic granulocytic leukemia: the role of intensive leukapheresis. Br. J. Haematol 1984; 56: 661–664
   PubMed Web of Science ®Google Scholar
• Dutcher J.P., Schiffer C.A., Wiernik P.H. Hyper-leukocytosis in adult acute non-lymphocytic leukemia: impact on remission rate and duration and survival. J. Clin. Oncol 1987; 9: 1364–1372
   Google Scholar
• Wiernik P.H., Serpick A.A. Factors affecting remission and survival in adult acute non-lymphocytic leukemia (ANLL). Medicine 1970; 49: 505–513
   PubMed Web of Science ®Google Scholar
• Hug V., Keating M.J., McCredie K.B., Hester J.P., Bodey G.P., Freireich E.J. Clinical course and response to treatment of patients with AML presenting with a high leukocyte count. Cancer 1983; 52: 773–779
   PubMed Web of Science ®Google Scholar
• Vaughan W.P., Kimball A.W., Karp J.E., Dragon L.H., Burke P.J. Factors affecting survival of patients with acute myelocytic leukemia presenting with high WBC counts. Cancer Treat. Rep 1981; 65: 1007–1013
   PubMedGoogle Scholar
• Hoelzer D., Thiel E., Loeffler H., Buchner T., Ganser A., Heil G., Koch P., Freund M., Diedrich H., Ruhl D., Mas-Chmeyer G., Lipp T., Nowrousian M.R., Burkert M., Gerecke D., Pralle H., Muller U., Lunschken C., Fulle H., Ho A.D., Kuchler R., Busch F.W., Schneider W, Gorg C., Emmerich B., Braumann D., Vaupel H.A., Von Paleske A., Battels H., Neiss A., Messerer D. Prognostic factors in a multi-center study for treatment of acute lymphoblastic leukemia in adults. Blood 1988; 71: 123–131
   PubMed Web of Science ®Google Scholar
• Hammond D., Sather H., Nesbit M., Coccia P., Bleyer A., Lukens J. Analysis of prognostic factors in acute lymphoblastic leukemia. Med. Pediatr. Oncol 1989; 14: 158–163
   Google Scholar
• Larson R.A., Dodge R.K., Burns C.P., Lee E.J., Stone R.M., Schulman P., Duggan D., Davey F.R., Sobol R.E., Frankel S.R., Hooberman A.L., Westbrook C.A., Arthur D.C., George S.L., Bloomfield CD., Schiffer C.A. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia. Cancer and Leukemia Group B study 8811. Blood 1995; 85: 2025–2031
   PubMed Web of Science ®Google Scholar
• Porcu P., Danielson C.F., Orazi A., Heerema N.A., Gabig T.G., McCarthy L.J. Therapeutic leukapheresis in hyperleukocytic leukemias: lack of correlation between degree of cytoreduction and early mortality rate. Br. J. Haematol 1997; 98: 433–436
   PubMed Web of Science ®Google Scholar
• Creutzig U., Ritter J., Budde M., Sutor A., Schellong G. German BMF Study Group. Early deaths due to hemorrhage and leukostasis in childhood acute myelogenous leukemia. Association with hyperleukocytosis and acute monocytic leukemia. Cancer 1987; 60: 3071–3079
   PubMed Web of Science ®Google Scholar
• Bunin N.J., Pui C.H. Differing complications of hyperleukocytosis in children with acute lymphoblastic or acute non-lymphoblastic leukemia. J. Clin. Oncol., 3: 1590–1595
   PubMed Web of Science ®Google Scholar
• Cuttner J., Holand J.F., Norton L., Ambinder E., Button G., Meyer R.J. Therapeutic leukapheresis for hyperleukocytosis in acute myelocytic leukemia. Med. Pediatr. Oncol 1983; 11: 76–78
   PubMedGoogle Scholar
• Ventura J.G., Hester P.J., Smith L.T., Keating J.M. Acute myeloblastic leukemia with hyperleukocytosis: risk factors for early mortality in induction. Am. J. Hematol 1988; 27: 34–39
   PubMed Web of Science ®Google Scholar
• Cuttner J., Conjalka M.S., Reilly M., Goldberg J., Reisman A., Meyer R.J., Holland J.F. Association of monocytic leukemia in patients with extreme leukocytosis. Am. J. Med 1980; 69: 555–558
   PubMed Web of Science ®Google Scholar
• Le Beau M.M., Larson R.A., Bitter M.A. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia: a unique cytogenetic-clinicopathologic association. N. Engl. J. Med. 1983.; 309, 630-634
   Google Scholar
• Larson R.A., Williams S.F., Le Beau M.M. Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis. Blood 1986.; 68, 1242-1248
   PubMed Web of Science ®Google Scholar
• Kaneko Y., Maseki N., Takasaki N., Sakurai M., Hayashi Y., Nakazawa S. Clinical and hematological characteristics in acute leukemia with 11q23 translocations. Blood 1986; 67: 484–489
   PubMed Web of Science ®Google Scholar
• Mirro J., Kitchingman G., Williams D., Lauzon G.J., Lin C.C., Callihan T., Zipf T.F. Clinical and laboratory characteristics of acute leukemia with the 4; 11 translocation. Blood 1986; 67: 689–693
   PubMed Web of Science ®Google Scholar
• Thirman M.J., Gill H.J., Burnett R.C. Rearrangements of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl. J. Med. 1993.; 329, 909-913
   Google Scholar
• Archimbaud E., Charrin C., Magaud J-P, Campos L., Thomas X., Fiere D., Rimokh R. Clinical and biological characteristics of adult de-novo and secondary acute myeloid leukemia with balanced 11q23 chromosomal anomaly or MLL gene rearrangement compared to cases with unbalanced 11q23 anomaly: confirmation of the existence of different entities with 11q23 breakpoint. Leukemia 1998; 12: 25–33
   PubMed Web of Science ®Google Scholar
• Slovak M.L., Kopecky K.J., Wolman S.R. Cytogenetic correlation with disease status and treatment outcome in advanced stage leukemia post bone marrow transplantation: a Southwest Oncology Group study. Leuk. Res. 1995.; 19, 381-388
   Google Scholar
• Lowenberg B., Suciu S., Archimbaud E., Ossenkoppele G.E.G., Verhoef G., Vellenga E., Wijermans P., Berneman Z., Dekker A.W., Strykmans P., Schouten H. Use of recombinant Granulocyte-Macrophage Colony Stimulating Factor during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia (AML) final report of AML-11, a Phase III randomized study of the Leukemia Cooperative Group of European Organization for the Research and Treatment of Cancer (EORTC-LCG) and the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON). Blood 1997; 90: 2952–2961
   PubMed Web of Science ®Google Scholar
• Berman E., Heller G., Santorsa J. Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. Blood 1991; 77: 1666–1671
   PubMed Web of Science ®Google Scholar
• Wiernik PH., Banks P.L.C., Case D.C. Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia. Blood 1992; 79: 313–318
   PubMed Web of Science ®Google Scholar
• Vogler W.R., Velez-Garcia E., Weiner R.S. a Phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group study. J. Clin. Oncol 1992; 10: 1103–1108
   PubMed Web of Science ®Google Scholar
• Reaman G.H., Sposto R., Sensel M., Lange B.J., Feusner J.H., Heerema N., Leonard M., Holmes E.J., Sather H.N., Pendergrass W., Johnstone H.S., O'Brien R.T., Steinherz P.G., Zeltzer P.M., Gaynon PS., Trigg M.E., Uckun F.M. Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group. J. Clin. Oncol 1999; 17: 445–455
   PubMed Web of Science ®Google Scholar
• Dearth J.C., Salter M., Wilson E., Kelly D., Christ W.M. Early death in acute leukemia in children. Med. Pediatr. Oncol 1983; 11: 225–228
   PubMedGoogle Scholar
• Wald B.R., Heisel M.A., Ortega J.A. Frequency of early death in children with acute leukemia presenting with hyperleukocytosis. Cancer 1982; 50: 150–153
   PubMed Web of Science ®Google Scholar
• Harousseau J.L., Tobelem G., Schaison G., Chastang C.I., Auclerc M.F., Weil M., Jaquillat C.I., Bernard J. High-risk acute lymphocytic leukemia: a study of 141 cases with initial WBC count over 100,000/mm3. Cancer 1980; 46: 1996–2003
   PubMed Web of Science ®Google Scholar
• Eguiguren J.M., Schell M.J., Christ W.M., Kunkel K., Rivera G.K. Complications and outcome of childhood acute lymphoblastic leukemia with hyperleukocytosis. Blood 1992; 79: 871–875
   PubMed Web of Science ®Google Scholar
• Maurer H.S., Steinherz P.G., Gaynon P.S., Fincklestein J.Z., Harland N.S., Reaman G.H., Bleyer W.A., Hammond G.D. The effect of the initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia. J. Clin. Oncol 1988; 6: 1425–1432
   PubMed Web of Science ®Google Scholar
• Pui C.H., Frankel L.S., Carrol A.J. Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23) a collaborative study of 40 cases. Blood 1991; 77: 440–447
   PubMed Web of Science ®Google Scholar
• Johansson B., Moorman A.V., Haas O.A. Hematologic malignancies with t(4;11)(q21;q23) a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. Leukemia 1998; 12: 779–787
   PubMed Web of Science ®Google Scholar
• Christ W., Carrol A., Schuster J. Philadelphia chromosome-positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome. A pediatric Oncology Group study. Blood 1990; 76: 489–494
   PubMed Web of Science ®Google Scholar
• Lestingi T.M., Hooberman A.L. Philadelphia chromosome-positive acute lymphoblastic leukemia. Hematol/Oncol. Clin. N. Am 1993; 7: 161–175
   PubMed Web of Science ®Google Scholar
• Uckun E, Sensel M, Sather H. Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group. J. Clin. Oncol 1998; 16: 527–535
   PubMed Web of Science ®Google Scholar
• Seeker-Walker L.M., Prentice H.G., Durrant J. Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukemia on MRC trial UKALL Xa. Br. J. Haematol 1997; 96: 601–610
   PubMed Web of Science ®Google Scholar
• Hunger S.P., Majilinde Z., Camitta B. E2A-PBX1 chimeric transcript status at the end of consolidation is not predictive of treatment outcome in childhood acute lymphoblastic leukemias with a t(1;19)(q23;p13) a Pediatric Oncology Group study. Blood 1998; 91: 1021–1028
   PubMed Web of Science ®Google Scholar
• Quesnel B., Preudhomme C., Philippe N., Vanrumbeke M., Dervite I., Lai J.L., Bauters R, Wattel E., Fenaux P. p16 gene homozygous deletions in acute lymphoblastic leukemia. Blood 1995; 85: 675–680
   PubMedGoogle Scholar
• Fizzotti M., Cimino G., Pisegna S., Alimena G., Quartarone C., Mandelli R, Pelicci P.G., Lo Coco F. Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. Blood 1995; 85: 2685–2690
   PubMed Web of Science ®Google Scholar
• Liggett W.H., Sidransky D. Role of the p16 tumor suppressor gene in cancer. J. Clin. Oncol 1998; 16: 1197–1206
   PubMed Web of Science ®Google Scholar
• Heyman M., Rasool O., Borgonovo-Brandter L., Liu Y., Grander D., Soderhall S., Gustavsson G., Einhorn S. Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphoblastic leukemia. J. Clin. Oncol. 1996; 14: 1512–1520
   PubMed Web of Science ®Google Scholar
• Smith M., Arthur D., Camitta B., Carrol A.J., Crist W., Gaynon P., Gelber R., Heerema N., Korn E.L., Link M., Murphy S., Pui C.H., Pullen J., Reamon G., Sallan S.E., Sather H., Shuster J., Simon R., Trigg M., Tubergen D., Uckun R, Ungerleider R. Uniform approach to risk classification and treatment assignement for children with acute lymphoblastic leukemia. J. Clin. Oncol 1996; 14: 18–24
   PubMed Web of Science ®Google Scholar
• McKee L.C., Collins R.D. Intravascular thrombi and aggregates as a cause of morbidity and mortality in leukemia. Medicine 1974; 53: 463–478
   PubMed Web of Science ®Google Scholar
• Van Buchem M.A., te Velde J., Willemze R., Spaander P.J. Leukostasis, an underestimated cause of death in leukemia. Blut 1988; 56: 39–44
   PubMedGoogle Scholar
• Soares F.A., Magnani-Landell G.A., de Miranda Cardoso M C. Pulmonary leukostasis without hyperleukocytosis: a clinicopathologic study of 16 cases. Am J. Hematol 1992; 40: 28–32
   PubMed Web of Science ®Google Scholar
• Litchmann M.A. Rheology of leukocytes, leukocyte suspensions, and blood in leukemia. J. Clin. Invest 1973; 52: 350–358
   PubMed Web of Science ®Google Scholar
• Steinberg M.H., Charm S.E. Effect of high concentrations of leukocytes on whole blood viscosity. Blood 1971; 38: 229–301
   PubMedGoogle Scholar
• Harris A.L. Leukostasis associated with blood transfusion in acute myeloid leukemia. Br. Med. J 1978; 2: 11691–11692
   Google Scholar
• Van Buchem M.A., Hogendoorn P.C., Levelt C.N., van Hengel P., Colly L.P., Kluin P.M. Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat. Leukemia 1992; 6: 142–149
   PubMed Web of Science ®Google Scholar
• Van Buchem M.A., Hogendoorn PC, Bruijn J.A., Kluin P.M. Endothelial activation antigens in pulmonary leukostasis in leukemia. Acta Haematol 1993; 90: 29–33
   PubMed Web of Science ®Google Scholar
• Stucki A., Cordey A.S., Monai N., Schapira M., Spertini O. Activation of vascular endothelial cells by leukemic blast cells: a mechanism of leukostasis. Blood 1995; 86: 435a
   Google Scholar
• Kubo H., Graham L., Doyle N.A., Quinlan W.M., Hogg J.C., Doerschuck CM. Complement fragment-induced release of neutrophils from bone marrow and sequestration within pulmonary capillaries in rabbits. Blood 1998; 92: 283–290
   PubMed Web of Science ®Google Scholar
• Van Buchem M.A., Levelt C.N., Hogendoorn P.C., Colly L.P., Kluin P.M., Willemze R. Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. Leukemia 1993; 7: 1608–1614
   PubMed Web of Science ®Google Scholar
• Liesveld J.L. Expression and function of adhesion receptors in acute myelogenous leukemia: parallels with normal erythroid and myeloid progenitors. Acta Haematol 1996; 97: 53–62
   Web of Science ®Google Scholar
• De Waele M., Renmans W., Jochmans K., Schots R., Lacor P., Trullemans P., Otten J., Balduck N., Vander Gucht K., Van Camp B., Van Riet I. Different expression of adhesion molecules on CD34+ cells in AML and B-lineage ALL and their normal bone marrow counterparts. Eur. J. Haematol 1999; 63: 192–201
   PubMed Web of Science ®Google Scholar
• Reuss-Borst M.A., Klein G., Waller H.D., Muller C.A. Differential expression of adhesion molecules in acute leukemia. Leukemia 1995; 9: 869–874
   PubMed Web of Science ®Google Scholar
• Spertini O., Preedman A.S., Belvin M.P., Penta A.C., Griffin J.D., Tedder T.C. Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells. Leukemia 1991; 5: 300–308
   PubMed Web of Science ®Google Scholar
• Archimbaud E., Thomas X., Campos L., Magaud J.P., Dore J.R, Fiere D. Expression of surface adhesion molecules CD54 (ICAM-1) and CD58 (LFA-3) in adult acute leukemia: relationship with initial clinical characteristics and prognosis. Leukemia 1992; 6: 265–271
   PubMed Web of Science ®Google Scholar
• Mielkarek M., Sperling C., Schrappe M., Meyer U., Riehm H., Ludwig W.D. Expression of intercellular adhesion molecule-1 (ICAM-1) in childhood acute lymphoblastic leukemia: correlation with clinical features and outcome. Br. J. Haematol 1997; 96: 301–307
   PubMed Web of Science ®Google Scholar
• Cavenagh J.D., Gordon-Smith E.C., Gibson P.M., Gordon M.Y. Acute myeloid leukemia blast cells bind to human endothelium in vitro utilizing E-selectin and vascular cell adhesion molecule-1 (VCAM). Br. J. Haematol 1993; 85: 285–291
   PubMed Web of Science ®Google Scholar
• Opdenakker G., Fibbe W.E., Van Damme J. The molecular basis of leukocytosis. Immunol. Today 1998; 19: 182–189
   Google Scholar
• Doerschuck CM., Quinlan W.M., Doyle N.A., Bullard D.C., Vestweber D., Jones M.L., Takei R, Ward P.A., Beaudet A.L. The roles of P-selectin and ICAM-1 in acute lung injury as determined using anti-adhesion molecule antibodies and mutant mice. J. Immunol 1996; 157: 4609–4614
   PubMed Web of Science ®Google Scholar
• Kamasaka T, Quinlan W.M., Doyle N.A., Condon T.E., Sligh J., Takei E, Beaudet A.L., Bennett C.F., Doerschuck C.M. The role of ICAM-1 in endotoxin-induced pneumonia evaluated using ICAM-1 antisense, anti-ICAM-1 antibodies and ICAM-1 mutant mice. J. Clin. Invest 1996; 97: 2362–2368
   PubMed Web of Science ®Google Scholar
• Di Noto R., Lo Pardo C., Schiavone E.M., Ferrara F., Manzo C., Vacca C., Del Vecchio L. All-trans retinoic acid (ATRA) and the regulation of adhesion molecules in acute myeloid leukemia. Leuk. Lymphoma 1994; 21: 201–209
   Web of Science ®Google Scholar
• Morigi M., Zoja C., Figliuzzi M., Foppolo M., Micheletti G., Bontempelli M., Saronni M., Remuzzi G., Remuzzi A. Fluid shear stress modulates surface expression of adhesion molecules by endothelial cells. Blood 1995; 85: 1696–1703
   PubMedGoogle Scholar
• Reinhardt P., Kubes P. Differential leukocyte recruitment from whole blood via endothelial adhesion molecules under shear conditions. Blood 1998; 92: 4691–4699
   PubMed Web of Science ®Google Scholar
• Chopp M., Zhang R.L., Chen H., Li Y., Jiang N., Rusche J.R. Post-ischemic administration of an anti-MAC-1 antibody reduces ischemia cell damage after transient middle cerebral artery occlusion in rats. Stroke 1994; 25: 869–674
   PubMed Web of Science ®Google Scholar
• Karakurum M., Shreeniwas R., Chen J., Pinsky D., Yan S.D., Anderson M., Sunouchi K., Major J., Hamilton T, Kuwabara K., Rot A., Nowyrod R., Stern D. Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J. Clin. Invest 1994; 93: 1564–1570
   PubMed Web of Science ®Google Scholar
• Baer M.R. Management of unusual presentations of acute leukemia. Hematol/Oncol. Clin. N. Am 1993; 7: 275–292
   PubMed Web of Science ®Google Scholar
• Van Buchem M.A., Wonderdergem J.A., Kool L.J.S., te Velde J., Kluin P.M., Bode P.J., Busscher D.L.T. Pulmonary leukostasis: radiologic pathologic study. Radiology 1987; 165: 739–741
   PubMed Web of Science ®Google Scholar
• Chillar R.K., Belman M.J., Farbstein M. Explanation for the apparent hypoxaemia associated with extreme leukocytosis: leukocytic oxygen consumption. Blood 1980; 55: 922–924
   PubMed Web of Science ®Google Scholar
• Gartrell K., Rosenstrauch W. Hypoxaemia in patients with hyperleukocytosis: true, spurious, and clinical implications. Leukemia Res. 1993; 17: 915–916
   Google Scholar
• Karesh J.W., Goldman E.J., Reck K., Kelman S.E., Lee E.J., Schiffer C.A. A prospective ophthalmologic evaluation of patients with acute myeloid leukemia: correlation of ocular and hematological findings. J. Clin. Oncol 1989; 10: 1528–1532
   Google Scholar
• Murray J.C., Dorfman S.R., Brandt M.L., Dreyer Z.E. Renal vein thrombosis complicating acute myeloid leukemia with hyperleukocytosis. J. Pediatr. Hematol/Oncol 1996; 18: 327–330
   PubMed Web of Science ®Google Scholar
• Mataix R., Gomez-Casares M.T., Campo C., Jimanez S., Malcorra J.J. Acute leg ischemia as a presentation of hyperleukocytosis syndrome in acute myeloid leukemia. Am. J. Hematol 1994; 46: 250–251
   PubMed Web of Science ®Google Scholar
• Campbell J., Mitchell C.A. Acute leg ischemia as a manifestation of the hyperleukocytosis syndrome in acute myeloid leukemia. Am J. Hematol 1994; 46: 167
   PubMed Web of Science ®Google Scholar
• Armitage J.O., Goeken J.A., Feagler J.R. Spurious elevation of the platelet count in acute leukemia. JAMA 1978; 239: 433–434
   PubMed Web of Science ®Google Scholar
• Frost T, Isbister J.P., Ravich R.B.M. Respiratory failure due to leukostasis in leukemia. Med. J. Austr 1981; 68: 94–96
   Google Scholar
• Lester T.J., Johnson J.W., Cuttner J. Pulmonary leukostasis as the single worst prognostic factor in patients with acute myelocytic leukemia and hyperleukocytosis. Am. J. Med 1985; 79: 43–48
   PubMed Web of Science ®Google Scholar
• Vernant J.P., Brun B., Mannoni P., Dreyfus B. Respiratory distress of hyperleukocytic granulocytic leukemias. Cancer 1979; 44: 264–268
   PubMed Web of Science ®Google Scholar
• Schiffer C.A. Therapeutic cytapheresis and plasma exchange. Neoplastic diseases of the blood, 3 Ed, P.H. Wiernick, G.P. Canellos, J.P. Dutcher, R.A. Kyle. Churchill Livingstone, New York, NY 1996; 1065–1076
   Google Scholar
• Ablin A.R. Managing the problem of hyperleukocytosis in acute leukemia. Am. J. Pediatr. Hematol. Oncol 1984; 6: 287–290
   PubMedGoogle Scholar
• McLeod B.C., Strauss R.G., Ciavarella D., Gilcher R.O., Kasprisin D.O., Kiprov D.D., Klein H.G. Management of hematological disorders and cancer. J. Clin. Apher-esis 1993; 8: 211–230
   PubMedGoogle Scholar
• Myers T.J., Cole S.R., Klatsky A.U., Hild D.H. Respiratory failure due to pulmonary leukostasis following chemotherapy of acute non-lymphocytic leukemia. Cancer 1983; 53: 1808–1813
   Web of Science ®Google Scholar
• Dombret H., Hunault M., Faucher C., Dombret M-C., Degos L. Acute lysis pneumopathy after chemotherapy for acute myelomonocytic leukemia with abnormal marrow eosinophils. Cancer, 69: 1356–1361
   PubMed Web of Science ®Google Scholar
• Tryka A.F., Godleski J.J., Fanta C.H. Leukemic cell lysis pneumopathy after chemotherapy: acomplication of treated myeloblasts leukemia. Cancer 1982; 50: 2763–2770
   PubMed Web of Science ®Google Scholar
• Wurthner J.U., Kohler G., Behringer D., Lindemann A., Mertelsmann R., Lubbert M. Leukostasis followed by hemorrhage complicating the initiation of chemotherapy in patients with acute myeloid leukemia and hyperleukocytosis. A clinicopathologic report of four cases. Cancer 1999; 85: 368–374
   Google Scholar
• Schwartz J.H., Canellos G.P. Hydroxyurea in the management of the hematologic complications of chronic granulocytic leukemia. Blood 1975; 46: 11–16
   PubMed Web of Science ®Google Scholar
• Grund EM., Armitage J.O., Burns C.P. Hydroxyurea in th eprevention of the effects of leukostasis in acute leukemia. Arch. Int. Med 1977; 137: 1246–1247
   PubMed Web of Science ®Google Scholar
• Strauss R.A., Gloster E.S., McCallister J.A., Jimenez J.E, Neuberg R.W., Berry D.H. Acute cytoreduction techniques in the early treatment of hyperleukocytosis associated with childhood hematological malignancies. Med. Pediatr. Oncol 1985; 13: 346–351
   PubMedGoogle Scholar
• Bunin N.J., Kunkel K., Callihan T.R. Cytoreductive procedures in the early management of cases of leukemia and hyperleukocytosis in children. Med. Pediatr. Oncol 1987; 15: 232–235
   PubMedGoogle Scholar
• Meyer R.J., Cuttner J., Truong P., Ambinder E.P., Holland J.E. Therapeutic leukapheresis of acute myelo-monocytic leukemia in pregnancy. Med. Pediatr. Oncol 1978; 4: 77–83
   PubMedGoogle Scholar
• Giles F.J., Kantarjian H., O'Brian S.M., Freireich E., Keating M.J., Estey E. Leukapheresis reduces early risk of mortality in acute myeloid leukemia (AML) patients receiving first induction therapy. Blood 1998; 92: 237a
   Web of Science ®Google Scholar
• Lascari A.D. Improvement of leukemic hyperleukocytosis with only fluid and allopurinol therapy (letter). Am. J. Dis. Child 1991; 145: 969
   Google Scholar
• Nelson S.C., Bruggers C.S., Kurtzberg J., Freidman H.S. Management of leukemic hyperleukocytosis with hydration, urinary alkalinization and allopurinol Are cranial irradiation and invasive cytoreduction necessary?. Am. J. Pediatr. Hematol. Oncol 1993; 1: 351–355
   Google Scholar
• Basade M., Dhar A.K., Kulkarni S.S., Sastry P.S.R.K., Yadv R.P., Parikh S.K., Pai S.K., Nair C.N., Kurkure PA., Advani S.H. Rapid cytoreduction in childhood leukemic hyperleukocytosis by conservative therapy. Med. Pediatr. Oncol 1995; 25: 204–207
   PubMedGoogle Scholar
• Nowacki P., Fryze C., Zdziarska B., Zyluk B., Grzelec H., Dudzik T. Central nervous system leukostasis in patients with leukemias and lymphomas. Folia Neuropathol 1995; 33: 59–65
   PubMedGoogle Scholar
• Porcu P., Danielson C.F.M., Orazi A., Buckwalter K., Lurito J., Skipworth E., McCarthy L.J. Acute lymphoblastic leukemia with hyperleukocytosis (HL) and supratentorial hemorrhage treated with leukapheresis. J. Clin. Apheresis 1998; 13, 82 (abstract)
   Google Scholar
• Flasshove M., Schuette J., Sauerwein W., Hoeffken K., Seeber S. Pulmonary and cerebral irradiation for hyperleukocytosis in acute myelomonocytic leukemia. Leukemia 1994; 8: 1792–1793
   PubMed Web of Science ®Google Scholar
• Butler R.W., Hill J.M., Steinherz P.G., Meyers P.A., Finlay J.L. Neuropsychological effects of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer. J. Clin. Oncol 1994; 12: 2621–2629
   PubMed Web of Science ®Google Scholar
• Nakagawa M., Bondy G.P., Waisman D., Minshall D., Hogg J.C., van Eden S.F. The effect of glucocorticoids on the expression of L-selectin on polymorphonuclear leukocytes. Blood 1999; 93: 2730–2737
   PubMed Web of Science ®Google Scholar
• Filep J.G., Delalandre A., Payette Y., Foldes-Filep E. Glucocorticoid receptor regulates the expression of L-selectin and CD11/CD18 on human neutrophils. Circulation 1997; 96: 295–301
   PubMed Web of Science ®Google Scholar
• Farsky S.P., Sannomiya P., Garcia L.J. Secreted glucocorticoids regulate leukocyte-endothelial interactions in inflammation. J. Leukocyte Biol 1995; 57: 379–386
   PubMed Web of Science ®Google Scholar
• Cronstein B.N., Kimmel S.C., Levin R.I., Martiniuk F., Weissmann G. A mechanisms for the anti-inflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1. Proc. Natl. Acad. Sci. USA 1992; 89: 9991–9995
   PubMed Web of Science ®Google Scholar
• Diaz-Gonzalez F., Sanchez-Madrid F. Inhibition of leukocyte adhesion: an alternative mechanism of action for anti-inflammatory drugs. Immunol. Today 1998; 19: 169–172
   Google Scholar
• Vahdat L., Maslak P., Miller W.H., Eardley A., Heller G., Scheinberg D.A., Warrell R.P. Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of leukocytosis, low-dose chemotherapy, PMN-RAR-alpha isoforms, and CD 13 expression in patients treated with all-trans retinoic acid. Blood 1994; 84: 3843–3849
   PubMed Web of Science ®Google Scholar
• Nakagawa M., Terashima T, D'yachkova Y, Bondy G.P., Hogg J.C., van Eden S.F. Glucocorticoid-induced granulocytosis: contribution of marrow release and demargination of intravascular granulocytes. Circulation 1998; 98: 2307–2312
   PubMed Web of Science ®Google Scholar